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https://www.readbyqxmd.com/read/28100244/is-aclidinium-alone-or-combined-with-a-laba-a-rational-choice-for-symptomatic-copd-patients
#1
REVIEW
F Blasi, G W Canonica, M Miravitlles
BACKGROUND: As emphasized by international recommendations and largely confirmed by clinical experience, long-acting bronchodilators play a central role in the maintenance treatment of chronic obstructive pulmonary disease (COPD) due to their proven efficacy in reducing airflow obstruction and improving symptoms. MAIN BODY: There are some important aspects to define with regard to inhalation therapy for COPD, particularly those concerning the selection criteria and the optimal use of long-acting bronchodilators...
January 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28079794/interventional-pulmonology-for-patients-with-central-airway-obstruction-an-8-year-institutional-experience
#2
Chia-Hung Chen, Biing-Ru Wu, Wen-Chien Cheng, Chih-Yu Chen, Wei-Chun Chen, Te-Chun Hsia, Wei-Chih Liao, Chih-Yen Tu, Wu-Huei Hsu
Patients with central airway obstruction (CAO) may need endobronchial intervention to relieve their symptoms. This report is on a single-center experience of using interventional bronchoscopy in terms of complications and survival. This retrospective study was conducted in a university hospital and involved 614 patients (464 men, 150 women; mean age, 60.2 years) with benign (n = 133) and malignant (n = 481) tracheobronchial disease who received 756 endobronchial intervention procedure during the period 2008 to 2015...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28077651/bromodomain-containing-4-brd4-couples-nf%C3%AE%C2%BAb-rela-with-airway-inflammation-and-the-irf-rig-i-amplification-loop-in-respiratory-syncytial-virus-infection
#3
Bing Tian, Jun Yang, Yingxin Zhao, Teodora Ivanciuc, Hong Sun, Roberto P Garofalo, Allan R Brasier
: The airway mucosa expresses protective interferon (IFN) and inflammatory cytokines in response to Respiratory Syncytial Virus (RSV) infection. In this study, we examine the role of bromodomain containing 4 (BRD4) in mediating this innate immune response in human small airway epithelial cells. We observe that RSV induces BRD4 to complex with NFκB/RelA. BRD4 is functionally required for expression of the NFκB-dependent inflammatory gene regulatory network (GRN), including the IFN Response Factor (IRFs)-1 and -7 that mediate a cross-talk pathway for RIG-I upregulation...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28043484/complete-postobstructive-lung-atelectasis-due-to-malignant-central-airway-obstruction-does-not-exclude-curative-chance
#4
Grigoris Stratakos, Anastasios Palamidas, Nikos Koufos, Charalambos Zisis
No abstract text is available yet for this article.
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28012784/positional-modification-techniques-for-supine-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#5
REVIEW
Hayley Barnes, Bradley A Edwards, Simon A Joosten, Matthew T Naughton, Garun S Hamilton, Eli Dabscheck
This review aimed to determine the effectiveness of positional modification techniques in preventing supine sleep, sleep-disordered breathing and other clinically important outcomes in patients with supine obstructive sleep apnea (OSA). Randomized controlled trials comparing positional modification techniques with any other therapy or placebo were included. Electronic searches of databases including CENTRAL, MEDLINE, CINAHL, Embase, and Web of Science up to April 2016 were performed. Meta-analysis was undertaken where possible...
November 18, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28012498/three-dimensional-imaging-forced-oscillation-technique-to-assess-position-dependent-airway-obstruction-in-relapsing-polychondritis-a-case-report
#6
Takahiro Kamada, Isao Ito, Yoshihiro Kanemitsu, Susumu Sato, Hisako Matsumoto, Akio Niimi, Michiaki Mishima
Relapsing polychondritis (RP) is characterized by recurrent systemic inflammation of the cartilages and is accompanied by central airway collapse. We report a case wherein three-dimensional imaging of respiratory system resistance (Rrs) and respiratory system reactance (Xrs) by using MostGraph (CHEST M.I., Tokyo, Japan), a forced oscillation system, revealed that Rrs and Xrs in the inspiratory and expiratory phases correlated with proximal airway collapse. The degree of difference in Rrs and Xrs between the supine and sitting positions reflected airway collapse more closely than did the pulmonary function test...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28005835/our-experience-on-silicone-y-stent-for-severe-copd-complicated-with-expiratory-central-airway-collapse
#7
Mehmet A Ozgul, Erdogan Cetinkaya, Mustafa Cortuk, Sinem Iliaz, Elif Tanriverdi, Sule Gul, Guler Ozgul, Hilal Onaran, Kenan Abbasli, Huseyin E Dincer
BACKGROUND: Expiratory central airway collapse (ECAC) is abnormal central airway narrowing during expiration. ECAC involves 2 different pathophysiological entities as tracheobronchomalacia and excessive dynamic airway collapse (EDAC). Although the exact cause is unknown, chronic obstructive pulmonary disease (COPD) is frequently accompanied by ECAC. Although there are various publications on the relationship between COPD and ECAC, there are very few data for stent placement in patients with tracheobronchomalacia accompanied severe COPD...
December 21, 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27998040/sleep-apnoea-in-heart-failure-to-treat-or-not-to-treat
#8
REVIEW
Matthew T Naughton, Kirk Kee
Heart failure (HF) and sleep apnoea are common disorders which frequently coexist. Two main types of apnoea occur: one is obstructive which, through recurring episodes of snoring, hypoxaemia, large negative intra-thoracic pressures and arousals from sleep leading to downstream inflammatory and autonomic nervous system changes, is thought to be a causative factor to the development of systemic hypertension and HF. The other type of apnoea, Cheyne-Stokes respiration with central sleep apnoea (CSR-CSA), is characterized by an oscillatory pattern of ventilation with a prevailing hyperventilation-induced hypocapnia, often in the absence of significant hypoxaemia and snoring, and is thought to be a consequence of advanced HF-related low cardiac output, high sympathetic nervous system activation and pulmonary congestion...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27990628/action-plans-with-brief-patient-education-for-exacerbations-in-chronic-obstructive-pulmonary-disease
#9
REVIEW
Maxwell Howcroft, E Haydn Walters, Richard Wood-Baker, Julia Ae Walters
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are a major driver of decline in health status and impose high costs on healthcare systems. Action plans offer a form of self-management that can be delivered in the outpatient setting to help individuals recognise and initiate early treatment for exacerbations, thereby reducing their impact. OBJECTIVES: To compare effects of an action plan for COPD exacerbations provided with a single short patient education component and without a comprehensive self-management programme versus usual care...
19, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27987505/-patient-related-independent-clinical-risk-factors-for-early-complications-following-interventional-pulmonology-procedures
#10
J J Huang, H Zhang, W Zhang, X Wang, Y H Gong, G F Wang
OBJECTIVE: To investigate the early complication rate and identify patient-related independent clinical risk factors for early complications in patients following interventional pulmonology procedures. METHODS: In the period from December 2014 to December 2015, sufficient data of Peking University First Hospital Respiratory and Critical Care Medicine Department for analysis were identified in 218 subjects. Interventional pulmonology procedures were performed in all the patients...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27986462/factors-contributing-to-unintentional-leak-during-cpap-treatment-a-systematic-review
#11
REVIEW
Marius Lebret, Jean-Benoit Martinot, Nathalie Arnol, Daniel Zerillo, Renaud Tamisier, Jean-Louis Pepin, Jean-Christian Borel
: Continuous positive airway pressure (CPAP) is the first-line treatment for moderate to severe obstructive sleep apnea syndrome (OSAS). Up to 25% of patients with OSAS discontinue CPAP treatment due to side effects. Unintentional leak and its associated annoying consequences are the most frequently reported adverse effects of CPAP. Successive technological improvements have not succeeded in addressing this issue. OBJECTIVES: A systematic review was conducted: (i) to assess the impact of different technological advances on unintentional leak and, (ii) to determine if any patient characteristics have already been identified as determinants of unintentional leak...
December 13, 2016: Chest
https://www.readbyqxmd.com/read/27978871/-interventional-bronchoscopies-for-the-treatment-of-112-cases-with-complex-malignant-central-airway-diseases-involved-in-bifurcation
#12
Hongwu Wang, Nan Zhang, Dongmei Li, Meimei Tao, Jieli Zhang, Hang Zou, Yunzhi Zhou, Sujuan Liang, Xiuyun Bai
BACKGROUND: It is very difficult to deal with the comprehensive central airway diseases, especially the malignant airway obstruction. The aim of this study is to explore the clinical effects of multiple interventional bronchoscopies for the treatment of 112 cases with comprehensive malignant central airway diseases so as to evaluate the clinical applications of thermoablation and cryosurgery. METHODS: The 112 cases with malignant airway diseases retrospectively reviewed for bronchoscopic interventions performed in more than two lesions of carina and/or bifurcation...
December 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27951583/bronchoscopic-drainage-of-lung-abscesses-using-a-pigtail-catheter
#13
Avraham Unterman, Oren Fruchter, Dror Rosengarten, Shimon Izhakian, Nader Abdel-Rahman, Mordechai R Kramer
BACKGROUND: Lung abscesses are commonly treated with antibiotics. However, some patients fail to respond and may require percutaneous catheter drainage or surgical intervention. Bronchoscopic drainage (BD) of lung abscesses emerged as a therapeutic alternative in selected patients. OBJECTIVE: To describe our experience with 15 patients who underwent BD at our center during 2006-2016. METHODS: Patients underwent flexible bronchoscopy. Under fluoroscopic guidance, a pigtail catheter was introduced into the abscess cavity, its correct position being confirmed by the injection of contrast medium...
December 13, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27940287/fast-onset-of-action-of-glycopyrronium-compared-with-tiotropium-in-patients-with-moderate-to-severe-copd-a-randomised-multicentre-crossover-trial
#14
Henrik Watz, Claudia Mailänder, Christoph May, Monika Baier, Anne-Marie Kirsten
BACKGROUND: Long-acting bronchodilators, including anticholinergics glycopyrronium and tiotropium, are central to symptomatic management of chronic obstructive pulmonary disease (COPD). In patients with moderate to severe COPD, glycopyrronium has demonstrated comparable efficacy to open-label and single-blinded tiotropium, but with faster onset of bronchodilation. The FAST study assessed the efficacy of glycopyrronium compared with tiotropium in serial spirometry and body plethysmography assessments to further characterize the earlier onset of action associated with glycopyrronium...
December 8, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27935962/map3k19-is-overexpressed-in-copd-and-is-a-central-mediator-of-cigarette-smoke-induced-pulmonary-inflammation-and-lower-airway-destruction
#15
Stefen A Boehme, Karin Franz-Bacon, John Ludka, Danielle N DiTirro, Tai Wei Ly, Kevin B Bacon
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung inflammation resulting in a progressive decline in lung function whose principle cause is cigarette smoke. MAP3K19 is a novel kinase expressed predominantly by alveolar and interstitial macrophages and bronchial epithelial cells in the lung. We found that MAP3K19 mRNA was overexpressed in a limited sampling of lung tissue from COPD patients, and a closer examination found it to be overexpressed in bronchoalveolar macrophages from COPD patients, as well as the bronchial epithelium and inflammatory cells in the lamina propria...
2016: PloS One
https://www.readbyqxmd.com/read/27930803/pulmonary-rehabilitation-following-exacerbations-of-chronic-obstructive-pulmonary-disease
#16
REVIEW
Milo A Puhan, Elena Gimeno-Santos, Christopher J Cates, Thierry Troosters
BACKGROUND: Guidelines have provided positive recommendations for pulmonary rehabilitation after exacerbations of chronic obstructive pulmonary disease (COPD), but recent studies indicate that postexacerbation rehabilitation may not always be effective in patients with unstable COPD. OBJECTIVES: To assess effects of pulmonary rehabilitation after COPD exacerbations on hospital admissions (primary outcome) and other patient-important outcomes (mortality, health-related quality of life (HRQL) and exercise capacity)...
8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27924176/our-clinical-experience-of-self-expanding-metal-stent-for-malignant-central-airway-obstruction
#17
Akash Verma, Chee Kiang Phua, Qiu Mei Wu, Wen Yuan Sim, Audrey Wee Chuan Rui, Soon Keng Goh, Benjamin Ho, Ai Ching Kor, Andrew S Y Wong, Albert Y H Lim, Dessmon Y H Tai, John Abisheganaden
BACKGROUND: We studied the safety, effectiveness, and limitations of airway stenting using self-expanding metal stent (SEMS) in patients with malignant central airway obstruction (CAO). METHODS: A retrospective review of records of patients undergoing SEMS placement for malignant CAO during year 2013 - 2014 was done. RESULTS: Sixteen patients (11 males and five females) underwent SEMS placement for malignant CAO. Median (range) age was 66 (54 - 78) years...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27909488/atrial-fibrillation-and-sleep-apnea-considerations-for-a-dual-epidemic
#18
REVIEW
Patricia Tung Md, Elad Anter Md
Atrial fibrillation (AF) is the most common cardiac arrhythmia and shares many of the same risk factors as another common clinical condition, sleep apnea. The estimated prevalence of sleep apnea has increased over the past decade, and reflects a parallel increase in the most prominent risk factors of obesity and overweight. Both obstructive and central sleep apnea have been associated with AF in multiple studies, with the risk of AF increasing 2-4-fold compared to those without sleep breathing disorder. Continuous positive airway pressure (CPAP) has been shown to reduce the rate of AF recurrence following catheter ablation in patients with sleep apnea...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27891001/rigid-bronchoscopic-management-of-acute-respiratory-failure-in-a-30-year-old-woman
#19
Karan Madan, Ashesh Dhungana, Neha Kawatra Madan, Anant Mohan, Vijay Hadda, Rakesh Garg, Deepali Jain, Randeep Guleria
A 30-year-old woman presented with a history of progressive shortness of breath, cough, and hoarseness. Stridor was audible on examination. Chest X-ray showed normal lung fields and contrast-enhanced computed tomography thorax showed lower tracheal occlusion with endoluminal growth. Diagnostic flexible bronchoscopy demonstrated multiple whitish glistening nodules over both vocal cords and lower tracheal occlusion by whitish nodular growth. In view of critical central airway obstruction, rigid bronchoscopy and excision of the lower tracheal growth were performed...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27889361/adult-bronchiectasis-patients-a-first-look-at-the-united-states-bronchiectasis-research-registry
#20
Timothy R Aksamit, Anne E O'Donnell, Alan Barker, Kenneth N Olivier, Kevin L Winthrop, M Leigh Anne Daniels, Margaret Johnson, Edward Eden, David Griffith, Michael Knowles, Mark Metersky, Matthias Salathe, Byron Thomashow, Gregory Tino, Gerard Turino, Betsy Carretta, Charles L Daley
OBJECTIVE: We sought to describe the characteristics of adult bronchiectasis patients enrolled in the United States Bronchiectasis Research Registry (BRR). METHODS: The BRR is a database of non-cystic fibrosis bronchiectasis (NCFB) patients enrolled at 13 sites within the United States. Baseline demographic, spirometric, imaging, microbiologic, and therapeutic data were entered into a central web-based database. Patients were subsequently analyzed by the presence NTM...
November 23, 2016: Chest
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