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https://www.readbyqxmd.com/read/28337282/chronic-intermittent-hypoxia-affects-endogenous-serotonergic-inputs-and-expression-of-synaptic-proteins-in-rat-hypoglossal-nucleus
#1
Xu Wu, Huan Lu, Lijuan Hu, Wankun Gong, Juan Wang, Cuiping Fu, Zilong Liu, Shanqun Li
Evidence has shown that hypoxic episodes elicit hypoglossal neuroplasticity which depends on elevated serotonin (5-HT), in contrast to the rationale of obstructive sleep apnea (OSA) that deficient serotonergic input to HMs fails to keep airway patency. Therefore, understanding of the 5-HT dynamic changes at hypoglossal nucleus (HN) during chronic intermittent hypoxia (CIH) will be essential to central pathogenic mechanism and pharmacological therapy of OSA. Moreover, the effect of CIH on BDNF-TrkB signaling proteins was quantified in an attempt to elucidate cellular cascades/synaptic mechanisms following 5-HT alteration...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28322440/psychological-therapies-for-the-treatment-of-anxiety-disorders-in-chronic-obstructive-pulmonary-disease
#2
REVIEW
Zafar A Usmani, Kristin V Carson, Karen Heslop, Adrian J Esterman, Anthony De Soyza, Brian J Smith
BACKGROUND: Chronic obstructive pulmonary disease (COPD) (commonly referred to as chronic bronchitis and emphysema) is a chronic lung condition characterised by the inflammation of airways and irreversible destruction of pulmonary tissue leading to progressively worsening dyspnoea. It is a leading international cause of disability and death in adults. Evidence suggests that there is an increased prevalence of anxiety disorders in people with COPD. The severity of anxiety has been shown to correlate with the severity of COPD, however anxiety can occur with all stages of COPD severity...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28286654/it-s-better-to-be-lucky%C3%A2-%C3%A2-%C3%A2-successful-management-of-an-acute-endobronchial-tumour-embolism-in-the-icu-a-case-report-and-review-of-the-literature
#3
Christopher J Walsh, Ron Olivenstein, Eric Forget, Anne V Gonzalez
Endobronchial tumour embolism is a rare cause of acute central airway obstruction. It is primarily reported during pneumonectomy, and the outcome is frequently fatal. Successful management requires the urgent removal of tumour with rigid or flexible bronchoscopy. We present the case of a 62-year-old woman with poorly differentiated non-small cell lung cancer (NSCLC), referred to our institution for Nd:YAG laser photoresection of endobronchial tumour completely obstructing the right mainstem bronchus (RMSB)...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28274235/multicenter-study-on-the-effectiveness-of-the-pre-epiglottic-baton-plate-for-airway-obstruction-and-feeding-problems-in-robin-sequence
#4
Christian F Poets, Christoph Maas, Wolfgang Buchenau, Joerg Arand, Anne Vierzig, Bert Braumann, Silvia Müller-Hagedorn
BACKGROUND: Treatment of Robin sequence is often either invasive or of unproven effectiveness. The pre-epiglottic baton plate (PEBP) is a well-studied alternative, yet is not widely applied internationally. We report on a prospective 3-center cohort study investigating this treatment. Based on an agreed protocol, parents of infants with Robin sequence referred to participating centers were offered enrollment, which involved taking a maxillary cast followed by endoscopy to fit the plate and sleep studies to monitor its effectiveness...
March 9, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28261503/cpap-treatment-partly-normalizes-sleep-spindle-features-in-obstructive-sleep-apnea
#5
Tiia Saunamäki, Eero Huupponen, Juho Loponen, Sari-Leena Himanen
Objective. Obstructive sleep apnea (OSA) decreases sleep spindle density and frequency. We evaluated the effects of continuous positive airway pressure (CPAP) treatment on different features of sleep spindles. Methods. Twenty OSA patients underwent two night polysomnographies in a diagnostic phase and one night polysomnography after 6 months of CPAP treatment. The control group comprised 20 healthy controls. Sleep spindles were analyzed by a previously developed automated method. Unilateral and bilateral spindles were identified in central and frontopolar brain locations...
2017: Sleep Disorders
https://www.readbyqxmd.com/read/28253561/the-neurology-of-acutely-failing-respiratory-mechanics
#6
Eelco F M Wijdicks
Forces involved in breathing-which effectively pull in air-are the diaphragmatic, intercostal, spine, and neck muscles. Equally important are the bulbar musculature maintaining the architecture of a patent airway conduit and abdominal wall and internal intercostal muscles providing cough. Acute injury along a neural trajectory from brainstem to muscle will impair the coordinated interaction between these muscle groups. Acutely failing respiratory mechanics can be caused by central and peripheral lesions. In central lesions, the key lesion is in the nucleus ambiguus innervating the dilator muscles of the soft palate, pharynx, and larynx, but abnormal respiratory mechanics rarely coincide with abnormalities of the respiratory pattern generator...
March 2, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28253389/technique-and-preliminary-analysis-of-drug-induced-sleep-endoscopy-with-online-polygraphic-cardiorespiratory-monitoring-in-patients-with-obstructive-sleep-apnea-syndrome
#7
Riccardo Gobbi, Simone Baiardi, Susanna Mondini, Luca Cerritelli, Ottavio Piccin, Giuseppe Scaramuzzino, Francesca Milano, Maria Rita Melotti, Francesco Mordini, Antonio Pirodda, Fabio Cirignotta, Giovanni Sorrenti
Importance: Drug-induced sleep endoscopy is a diagnostic technique that allows dynamic evaluation of the upper airway during artificial sleep. The lack of a standardized procedure and the difficulties associated with direct visual detection of obstructive events result in poor intraobserver and interobserver reliability, especially when otolaryngology surgeons not experienced in the technique are involved. Objectives: To describe a drug-induced sleep endoscopy technique implemented with simultaneous polygraphic monitoring of cardiorespiratory parameters (DISE-PG) in patients with a diagnosis of obstructive sleep apnea syndrome and discuss the technique's possible advantages compared with the standard procedure...
March 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28248822/mucous-membrane-pemphigoid-causing-central-airway-obstruction
#8
Bilal A Jalil, Yara G Abdou, Stephanie A Rosen, Tarek Dammad
Mucous membrane pemphigoid (MMP) is a rare variant of the skin disease pemphigoid, which predominantly involves the mucous membranes. This rare autoimmune disease that infrequently affects the respiratory tract is characterized by subepithelial blister formation that may result in scarring. Immunopathologic examination of mucous membranes reveals the deposition of immunoglobulins and complement within the subepithelial basement membrane. We describe a patient with undiagnosed MMP, with a near-fatal presentation of central airway obstruction causing acute respiratory distress...
February 28, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28238295/use-of-intranasal-corticosteroids-in-adenotonsillar-hypertrophy
#9
E U Sakarya, N Bayar Muluk, E G Sakalar, M Senturk, M Aricigil, S A Bafaqeeh, C Cingi
OBJECTIVES: This review examined the efficacy of intranasal corticosteroids for improving adenotonsillar hypertrophy. METHOD: The related literature was searched using PubMed and Proquest Central databases. RESULTS: Adenotonsillar hypertrophy causes mouth breathing, nasal congestion, hyponasal speech, snoring, obstructive sleep apnoea, chronic sinusitis and recurrent otitis media. Adenoidal hypertrophy results in the obstruction of nasal passages and Eustachian tubes, and blocks the clearance of nasal mucus...
February 27, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28229031/characterization-of-sleep-architecture-in-down-syndrome-patients-pre-and-post-airway-surgery
#10
Mark Mims, Prasad John Thottam, Dennis Kitsko, Amber Shaffer, Sukgi Choi
OBJECTIVES: To define obstructive sleep architecture patterns in Down syndrome (DS) children as well as changes to sleep architecture patterns postoperatively. STUDY DESIGN: The study was a retrospective review. METHODS: Forty-five pediatric DS patients who underwent airway surgery between 2003 and 2014 at a tertiary children's hospital for obstructive sleep apnea (OSA) were investigated. Postoperative changes in respiratory parameters and sleep architecture (SA) were assessed and compared to general pediatric normative data using paired t-tests and Wilcoxon signed-rank test...
January 17, 2017: Curēus
https://www.readbyqxmd.com/read/28224726/a%C3%A4-rway-and-sleep-d%C3%A4-sorders-%C3%A4-n-pat%C3%A4-ents-w%C3%A4-th-acromegaly
#11
Onur Turan, Barış Akıncı, Ahmet Omer Ikız, Oya Itıl, Ibrahim Oztura, Emel Ada, Bahri Akdenız, Serkan Yener, Murat Kaya, Arzu Gedık, Abdurrahman Comlekcı
INTRODUCTION-OBJECTIVE: Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep-disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular and upper airway systems in acromegalic patients. METHODS: The study group consisted of 30 acromegaly outpatients. GH and insulin-like growth factor 1 (IGF-1) measurements were obtained; body pletysmography, arterial blood gas analysis,tissue-doppler imaging,echocardiography,polysomnography,otorhinolaryngologic examination and head-neck computed tomography were performed...
February 22, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28197218/polysomnographic-findings-in-infants-with-pierre-robin-sequence
#12
Abdullah Khayat, Saadoun Bin-Hassan, Suhail Al-Saleh
INTRODUCTION: Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and upper airway obstruction. It is commonly associated with the secondary cleft palate. Infants with PRS commonly have sleep-disordered breathing (SDB); including obstructive sleep apnea (OSA) as well as central sleep breathing abnormalities that are present from infancy. AIM OF THE STUDY: Evaluate the prevalence and severity of SDB in infants with PRS using polysomnography (PSG)...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28190631/severe-esophageal-dilation-causing-central-airway-obstruction-a-rare-complication-of-lagb
#13
Michael R Freund, Ram M Spira, Petachia Reissman
No abstract text is available yet for this article.
December 19, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28171878/antibacterial-defense-of-human-airway-epithelial-cells-from-chronic-obstructive-pulmonary-disease-patients-induced-by-acute-exposure-to-nontypeable-haemophilus-influenzae-modulation-by-cigarette-smoke
#14
Gimano D Amatngalim, Jasmijn A Schrumpf, Almira Henic, Esther Dronkers, Renate M Verhoosel, Soledad R Ordonez, Henk P Haagsman, Maria E Fuentes, Sriram Sridhar, Jamil Aarbiou, Richard A J Janssen, Annemarie N Lekkerkerker, Pieter S Hiemstra
Antimicrobial proteins and peptides (AMPs) are a central component of the antibacterial activity of airway epithelial cells. It has been proposed that a decrease in antibacterial lung defense contributes to an increased susceptibility to microbial infection in smokers and patients with chronic obstructive pulmonary disease (COPD). However, whether reduced AMP expression in the epithelium contributes to this lower defense is largely unknown. We investigated the bacterial killing activity and expression of AMPs by air-liquid interface-cultured primary bronchial epithelial cells from COPD patients and non-COPD (ex-)smokers that were stimulated with nontypeable Haemophilus influenzae (NTHi)...
February 8, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28159090/management-of-sleep-apnea-syndromes-in-heart-failure
#15
REVIEW
Bernardo J Selim, Kannan Ramar
Central sleep apnea (CSA) and obstructive sleep apnea (OSA) are prevalent in heart failure (HF) and associated with a worse prognosis. Nocturnal oxygen therapy may decrease CSA events, sympathetic tone, and improve left ventricular ejection fraction, although mortality benefit is unknown. Although treatment of OSA in patients with HF is recommended, therapy for CSA remains controversial. Continuous positive airway pressure use in HF-CSA may improve respiratory events, hemodynamics, and exercise capacity, but not mortality...
March 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/28144067/stenting-of-critical-tracheal-stenosis-with-adjuvant-cardio-pulmonary-bypass
#16
Himanshu Bhardwaj, Ahmed Awab, Houssein A Youness, Brent Brown
Severe and critical central airway obstruction causing impaired ventilation and/or oxygenation can impose tremendous challenges on the interventional pulmonologist. Near total airway obstruction can rapidly evolve into potentially fatal complete airway occlusion during bronchoscopic airway manipulation under moderate sedation; as well as during the induction of the general anesthesia. Although there are currently interventional pulmonary procedures available to tackle the critical airway obstruction in extreme situations, cardio-pulmonary bypass should be considered prior to the intervention to maintain the adequate gas exchange during the procedure...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28143688/sleep-apnea-state-of-the-art
#17
REVIEW
Martin R Cowie
Many patient with, or at risk of, cardiovascular disease have sleep disordered breathing (SDB), which can be either obstructive (with intermittent collapse of the upper airway) or central (episodic loss of respiratory drive). SDB is associated with sleep disturbance, hypoxemia, hemodynamic changes, and sympathetic activation. Such patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and partially normalize the sleep and respiratory physiology, but recent randomized trials of cardiovascular outcomes in SDB have either been neutral (obstructive sleep apnea) or suggested the possibility of harm, likely from increased sudden death, in central sleep apnea...
December 20, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28126502/-therapeutic-alternatives-to-continuous-positive-airway-pressure-for-obstructive-sleep-apnea-hypopnea-syndrome
#18
Frédéric Gagnadoux, Marie Jouvenot, Nicole Meslier, Pascaline Priou, Wocjiech Trzepizur
Oral appliance therapy (OAT) is the main therapeutic alternative to continuous positive airway pressure (CPAP). OAT has been recommended as an appropriate first-line treatment option for moderate obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients without severe cardiovascular comorbidity. The lower efficacy of OAT in reducing sleep-disordered breathing could be offset by a higher compliance relative to CPAP, resulting in similar health outcomes in terms of sleepiness, neurobehavioral functioning, quality of life and blood pressure...
January 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28123669/-diagnosis-of-sleep-apnea-in-network-respiratory-polygraphy-as-a-decentralization-strategy
#19
Eduardo Borsini, Magali Blanco, Martin Bosio, Di Tullio Fernando, Glenda Ernst, Alejandro Salvado
INTRODUCTION: Obstructive sleep apnea syndrome (OSA) is diagnosed through polysomnography (PSG) or respiratory polygraphy (RP). Self-administered home-based RP using devices with data transmission could facilitate diagnosis in distant populations. The purpose of this work was to describe a telemedicine initiative using RP in four satellite outpatient care clinics (OCC) of Buenos Aires Hospital Británico Central (HBC). MATERIALS AND METHODS: OCC technicians were trained both in the use of RP...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28116747/pneumococcal-vaccines-for-preventing-pneumonia-in-chronic-obstructive-pulmonary-disease
#20
REVIEW
Julia Ae Walters, Joanne Ngie Qing Tang, Phillippa Poole, Richard Wood-Baker
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) are at increased risk of pneumococcal disease, especially pneumonia, as well as acute exacerbations with associated morbidity and healthcare costs. OBJECTIVES: To determine the efficacy of injectable pneumococcal vaccination for preventing pneumonia in persons with COPD. SEARCH METHODS: We searched the Cochrane Airways COPD Trials Register and the databases CENTRAL, MEDLINE and Embase, using prespecified terms...
January 24, 2017: Cochrane Database of Systematic Reviews
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