keyword
https://read.qxmd.com/read/38168372/a-plasma-peptidomic-signature-reveals-extracellular-matrix-remodeling-and-predicts-prognosis-in-alcohol-related-hepatitis
#21
Khaled Sayed, Christine E Dolin, Daniel W Wilkey, Jiang Li, Toshifumi Sato, Juliane I Beier, Josepmaria Argemi, Ramon Bataller, Abdus S Wahed, Michael L Merchant, Panayiotis V Benos, Gavin E Arteel
UNLABELLED: Alcohol-related hepatitis (AH) is plagued with high mortality and difficulty in identifying at-risk patients. The extracellular matrix undergoes significant remodeling during inflammatory liver injury that can be detected in biological fluids and potentially used for mortality prediction. EDTA plasma samples were collected from AH patients (n= 62); Model for End-Stage Liver Disease (MELD) score defined AH severity as moderate (12-20; n=28) and severe (>20; n=34). The peptidome data was collected by high resolution, high mass accuracy UPLC-MS...
December 14, 2023: medRxiv
https://read.qxmd.com/read/38134103/an-aging-related-gene-signature-to-predict-the-prognosis-of-hepatocellular-carcinoma
#22
JOURNAL ARTICLE
Yanfei Fang, Wenjing Yang, Lexi Wu, Lingya Yao, Xianghan Cao, Haotian Chen
Aging increases the susceptibility of various diseases, including hepatocellular carcinoma (HCC). This study aimed to establish an aging-related prognostic model for HCC and to investigate the role of aging-related genes in HCC progression. Transcriptome and clinical information of HCC cases were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Aging-related prognostic genes were identified through univariate Cox regression analysis, protein-protein interaction analysis, and least absolute shrinkage and selection operator (LASSO) analysis...
December 22, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38115636/exploration-of-the-biomarkers-of-comorbidity-of-psoriasis-with-inflammatory-bowel-disease-and-their-association-with-immune-infiltration
#23
JOURNAL ARTICLE
Rui-Lian Ding, Yu Zheng, Jin Bu
BACKGROUND: There was evidence that significant bidirectional associations between psoriasis and inflammatory bowel diseases (IBDs), which influences management strategy of the patients, so the investigation on the mechanisms by which these two diseases co-occur is important. METHODS: The Gene Expression Omnibus (GEO) database was used to download gene expression profiles of psoriasis and IBD. The differentially expressed genes (DEGs) between disease and health control groups for each data set were calculated, and Venn diagram was used to obtain for intersection...
December 2023: Skin Research and Technology
https://read.qxmd.com/read/38074471/up-regulated-spp1-increases-the-risk-from-ipf-to-lung-cancer-via-activating-the-pro-tumor-macrophages
#24
JOURNAL ARTICLE
Tingting Chen, Jiayu Guo, Liqiang Ai, Yuquan Wang, Yan Wang, Bo Chen, Mingyue Liu, Shuping Zhuang, Kaidong Liu, Zhangxiang Zhao, Haihai Liang, Yunyan Gu
The incidence of lung cancer (LC) in Idiopathic Pulmonary Fibrosis (IPF) patients is more than twice that in non-IPF. This study aims to investigate IPF-to-LC pathogenesis and to develop a predictor for detecting IPF predisposing patients to LC. We conducted unsupervised clustering to detect high-risk subtypes from IPF to LC. Subsequently, we performed single-cell RNA-seq analysis to characterize high-risk IPF by examining the immune microenvironment. We identified 42 common immune function-related pathogenic genes between IPF and LC...
2023: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/38069304/mmp12-is-translationally-regulated-in-macrophages-during-the-course-of-inflammation
#25
JOURNAL ARTICLE
Silvia Kuntschar, Giulia Cardamone, Kevin Klann, Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Peter Rappl, Christian Münch, Bernhard Brüne, Tobias Schmid
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase, remain largely elusive. In the present study, we analyzed translational changes in inflammatory bone marrow-derived macrophages upon resolution-promoting efferocytosis. Total RNA-sequencing confirmed that apoptotic cell phagocytosis induced a pro-resolution signature in LPS/IFNγ-stimulated macrophages (Mϕ)...
November 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38067435/integrative-analysis-of-machine-learning-and-molecule-docking-simulations-for-ischemic-stroke-diagnosis-and-therapy
#26
JOURNAL ARTICLE
Jingwei Song, Syed Aqib Ali Zaidi, Liangge He, Shuai Zhang, Guangqian Zhou
Due to the narrow therapeutic window and high mortality of ischemic stroke, it is of great significance to investigate its diagnosis and therapy. We employed weighted gene coexpression network analysis (WGCNA) to ascertain gene modules related to stroke and used the maSigPro R package to seek the time-dependent genes in the progression of stroke. Three machine learning algorithms were further employed to identify the feature genes of stroke. A nomogram model was built and applied to evaluate the stroke patients...
November 22, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38017481/genetic-deletion-of-mmp12-ameliorates-cardiometabolic-disease-by-improving-insulin-sensitivity-systemic-inflammation-and-atherosclerotic-features-in-mice
#27
JOURNAL ARTICLE
Melina Amor, Valentina Bianco, Martin Buerger, Margarete Lechleitner, Nemanja Vujić, Anja Dobrijević, Alena Akhmetshina, Anita Pirchheim, Birgit Schwarz, Ariane R Pessentheiner, Franziska Baumgartner, Katharina Rampitsch, Silvia Schauer, Iva Klobučar, Vesna Degoricija, Gudrun Pregartner, Daniel Kummer, Monika Svecla, Gerhard Sommer, Dagmar Kolb, Gerhard A Holzapfel, Gerald Hoefler, Saša Frank, Giuseppe Danilo Norata, Dagmar Kratky
BACKGROUND: Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining the contributions of MMP12 to CMDs are still unclear. METHODS: We investigated the impact of MMP12 deficiency on CMDs in a mouse model that mimics human disease by simultaneously developing adipose tissue inflammation, insulin resistance, and atherosclerosis...
November 28, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/38004080/genetic-variants-in-matrix-metalloproteinases-mmp3-rs3025058-and-mmp9-rs3918242-associated-with-colonic-diverticulosis
#28
JOURNAL ARTICLE
Piotr Nehring, Grażyna Gromadzka, Miłosz Jastrzębski, Adam Przybyłkowski
Background and Objectives : Diverticulosis affects a significant portion of the elderly population, with age and lifestyle being established risk factors. Additionally, genetic predisposition is gaining recognition as a contributing factor. This pilot study sought to explore the frequency of genetic variants in matrix metalloproteinases (MMPs) 3, 9, and 12 in a population of colonic diverticulosis patients. Materials and Methods : The study encompassed 134 participants: 59 diagnosed with colon diverticulosis during colonoscopy and 75 healthy controls...
November 17, 2023: Medicina
https://read.qxmd.com/read/37985993/vascular-cell-adhesion-molecule-1-vcam-1-contributes-to%C3%A2-macular-fibrosis-in-neovascular-age-related-macular-degeneration-through-modulating-macrophage-functions
#29
JOURNAL ARTICLE
Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen, Heping Xu
BACKGROUND: Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to the growth of abnormal blood vessels into the macula, leading to the loss of central vision. Intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors (e.g., anti-VEGF) is the standard of care for nAMD. However, nearly 50% of patients do not respond or respond poorly to the therapy. More importantly, up to 70% of nAMD patients develop macular fibrosis after 10 years of anti-VEGF therapy...
November 20, 2023: Immunity & Ageing: I & A
https://read.qxmd.com/read/37978381/prediction-and-validation-of-common-targets-in-atherosclerosis-and-non-small-cell-lung-cancer-influenced-by-atorvastatin
#30
JOURNAL ARTICLE
Yu-Qian Li, Lu-Yao Li, Xue Yang, Qi-Qi Lei, Liu-Yan Xiang, Yuan-Ru Wang, Si-Meng Gu, Ya-Jun Cao, Yan Pan, Lu Tie, Xue-Jun Li
BACKGROUND: Cardiovascular disease and cancer are the main causes of morbidity and mortality worldwide. Studies have shown that these two diseases may have some common risk factors. Atorvastatin is mainly used for the treatment of atherosclerosis in clinic. A large number of studies show that atorvastatin may produce anti-tumor activities. This study aimed to predict the common targets of atorvastatin against atherosclerosis and non-small cell lung cancer (NSCLC) based on network pharmacology...
November 17, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37969383/establishment-and-verification-of-a-prognostic-risk-score-model-based-on-immune-genes-for-hepatocellular-carcinoma-in-an-asian-population
#31
JOURNAL ARTICLE
Yanjie Wang, Zhengyang Feng, Yingtian Zhang, Yusong Zhang
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with the highest incidence in East Asia, and hepatitis B virus (HBV) infection is the most common cause of HCC in Asian population. The immune system is closely related to the development of HCC and plays an important role in the treatment of this disease. In this study, we analyzed the data of HCC from The Cancer Genome Atlas (TCGA) database and constructed a risk-score prognostic model based on immune genes of an Asian HCC population, aiming to provide new perspectives for clinical treatment and management of HCC in Asian population...
October 31, 2023: Translational Cancer Research
https://read.qxmd.com/read/37961084/multi-modal-skin-atlas-identifies-a-multicellular-immune-stromal-community-associated-with-altered-cornification-and-specific-t-cell-expansion-in-atopic-dermatitis
#32
Evgenij Fiskin, Gökcen Eraslan, Maria B Alora-Palli, Juan Manuel Leyva-Castillo, Sean Kim, Heather Choe, Caleb A Lareau, Helena Lau, Emily P Finan, Isabella Teixeira-Soldano, Brenna LaBere, Anne Chu, Brian Woods, Janet Chou, Michal Slyper, Julia Waldman, Sabina Islam, Lynda Schneider, Wanda Phipatanakul, Craig Platt, Orit Rozenblatt-Rosen, Toni M Delorey, Jacques Deguine, Gideon P Smith, Raif Geha, Aviv Regev, Ramnik Xavier
In healthy skin, a cutaneous immune system maintains the balance between tolerance towards innocuous environmental antigens and immune responses against pathological agents. In atopic dermatitis (AD), barrier and immune dysfunction result in chronic tissue inflammation. Our understanding of the skin tissue ecosystem in AD remains incomplete with regard to the hallmarks of pathological barrier formation, and cellular state and clonal composition of disease-promoting cells. Here, we generated a multi-modal cell census of 310,691 cells spanning 86 cell subsets from whole skin tissue of 19 adult individuals, including non-lesional and lesional skin from 11 AD patients, and integrated it with 396,321 cells from four studies into a comprehensive human skin cell atlas in health and disease...
October 31, 2023: bioRxiv
https://read.qxmd.com/read/37907504/eqtl-colocalization-analysis-highlights-novel-susceptibility-genes-in-autism-spectrum-disorders-asd
#33
JOURNAL ARTICLE
S Dominguez-Alonso, A Carracedo, C Rodriguez-Fontenla
Autism Spectrum Disorders (ASD) are a group of neurodevelopmental disorders (NDDs) characterized by difficulties in social interaction and communication, repetitive behavior, and restricted interests. ASD has proven to have a strong genetic component. However, defining causal genes is still one of the main challenges in GWAS, since the vast majority (>90%) of detected signals lie within the non-coding genome. Expression quantitative trait locus (eQTL) colocalization analysis determines whether a specific variant is responsible for both a local eQTL and GWAS association and has helped leverage data and rendering gene discovery for a wide array of diseases...
October 31, 2023: Translational Psychiatry
https://read.qxmd.com/read/37889539/immunobiological-signatures-and-the-emerging-role-of-spp1-in-predicting-tumor-heterogeneity-malignancy-and-clinical-outcomes-in-stomach-adenocarcinoma
#34
JOURNAL ARTICLE
Yanan Wu, Lingyu Ren, Yichun Tang, Zhu Zhu, Shifan Liu, Yan Jiang, Siming Zhang, Xiaocan Zhuang, Yuanbiao Chen
BACKGROUND: Immunotherapy, as a form of immunobiological therapy, represents a promising approach for enhancing patients' immune responses. This work aims to present innovative ideas and insights for prognostic assessment and clinical treatment of stomach adenocarcinoma (STAD) by leveraging immunobiological signatures. METHODS: We employed weighted gene co-expression network analysis (WGCNA) and unsupervised clustering analysis to identify hub genes. These hub genes were utilized to construct a prognostic risk model, and their impact on the tumor microenvironment (TME) and DNA variations was assessed using large-scale STAD patient cohorts...
October 26, 2023: Aging
https://read.qxmd.com/read/37872946/tissue-specific-expression-of-senescence-biomarkers-in-spontaneously-hypertensive-rats-evidence-of-premature-aging-in-hypertension
#35
JOURNAL ARTICLE
Ratthapon Somsura, Kanokwan Kamkajon, Khuanjit Chaimongkolnukul, Surachai Chantip, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Nuntaporn Kamonsutthipaijit, Suwimol Tangtrongsup, Nattapon Panupinthu, Wacharaporn Tiyasatkulkovit, Narattaphol Charoenphandhu
BACKGROUND: Cellular senescence is an age-related physiological process that contributes to tissue dysfunction and accelerated onset of chronic metabolic diseases including hypertension. Indeed, elevation of blood pressure in hypertension coincides with premature vascular aging and dysfunction. In addition, onsets of metabolic disturbance and osteopenia in patients with hypertension have also been reported. It is possible that hypertension enhances premature aging and causes progressive loss of function in multiple organs...
2023: PeerJ
https://read.qxmd.com/read/37864932/sodium-butyrate-sb-ameliorated-inflammation-of-copd-induced-by-cigarette-smoke-through-activating-the-gpr43-to-inhibit-nf-%C3%AE%C2%BAb-mapks-signaling-pathways
#36
JOURNAL ARTICLE
Zhijun Zhao, Yongqing Tong, Yuting Kang, Zhuoran Qiu, Qiujie Li, Chao Xu, Geng Wu, Wei Jia, Pengtao Wang
Cigarette smoke is recognized as a major trigger for individuals with chronic obstructive pulmonary disease (COPD), leading to an amplified inflammatory response. The onset and progression of COPD are affected by multiple environmental and genetic risk factors, such as inflammatory mechanisms, oxidative stress, and an imbalance between proteinase and antiprotease. As a result, conventional drug therapies often have limited effectiveness. This study aimed to investigate the anti-inflammatory effect of sodium butyrate (SB) in COPD and explore its molecular mechanism, thereby deepening our understanding of the potential application of SB in the treatment of COPD...
October 19, 2023: Molecular Immunology
https://read.qxmd.com/read/37816293/macrophage-derived-mmp12-promotes-fibrosis-through-sustained-damage-to-endothelial-cells
#37
JOURNAL ARTICLE
Xinbei Zhou, Cong Zhang, Shaoqi Yang, Liliang Yang, Wei Luo, Wei Zhang, Xinxin Zhang, Jie Chao
Macrophages are essential for the maintenance of endothelial cell function. However, the potential impact and mechanisms of crosstalk between macrophages and endothelial cells during silicosis progression remain unexplored. To fill this knowledge gap, a mouse model of silicosis was established. Single cell sequencing, spatial transcriptome sequencing, western blotting, immunofluorescence staining, tube-forming and wound healing assays were used to explore the effects of silicon dioxide on macrophage-endothelial interactions...
October 6, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/37812024/prognostic-and-clinicopathological-significance-of-mmp12-in-various-cancers-a-meta-analysis-and-bioinformatics-analysis
#38
JOURNAL ARTICLE
Yangjing Teng, Xinyi Fu, Qin Zhang, Feiyang Wang, Yan Liu, Zhenhong Zou
Background: Cancer is one of the top causes of mortality worldwide. The matrix metalloproteinase MMP12 is highly expressed in some cancers, but there is a lack of meta-analyses proving the correlation between MMP12 and cancer. Materials & methods: A literature search was performed using Web of Science, PubMed and other databases. Quantitative meta-analysis of the data was carried out. The Cancer Genome Atlas was further used to validate our results. Results: High MMP12 expression was associated with poorer overall survival and poorer 5-year overall survival...
October 9, 2023: Biomarkers in Medicine
https://read.qxmd.com/read/37797918/loss-of-carnitine-palmitoyltransferase-1a-reduces-docosahexaenoic-acid-containing-phospholipids-and-drives-sexually-dimorphic-liver-disease-in-mice
#39
JOURNAL ARTICLE
Mikala M Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E Mead, Zachary A Kipp, Evelyn A Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R Shelman, Harrison A Clarke, Tara R Hawkinson, Terrymar Medina, Ramon C Sun, Todd A Lydic, Terry D Hinds, J Mark Brown, Samir Softic, Gregory A Graf, Robert N Helsley
BACKGROUND AND AIMS: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic lipid metabolism. APPROACH AND RESULTS: Male and female liver-specific knockout (LKO) and littermate controls were placed on a low-fat or high-fat diet (60% kcal fat) for 15 weeks. Mice were necropsied after a 16 hour fast, and tissues were collected for lipidomics, matrix-assisted laser desorption ionization mass spectrometry imaging, kinome analysis, RNA-sequencing, and protein expression by immunoblotting...
October 3, 2023: Molecular Metabolism
https://read.qxmd.com/read/37754256/administration-of-tamoxifen-can-regulate-changes-in-gene-expression-during-the-acute-phase-of-traumatic-spinal-cord-injury
#40
JOURNAL ARTICLE
Eibar E Cabrera-Aldana, Yalbi I Balderas-Martinez, Rafael Velázquez-Cruz, Luis B Tovar-Y-Romo, Rosalba Sevilla-Montoya, Angelina Martínez-Cruz, Claudia Martinez-Cordero, Margarita Valdes-Flores, Monica Santamaria-Olmedo, Alberto Hidalgo-Bravo, Gabriel Guízar-Sahagún
Traumatic spinal cord injury (SCI) causes irreversible damage leading to incapacity. Molecular mechanisms underlying SCI damage are not fully understood, preventing the development of novel therapies. Tamoxifen (TMX) has emerged as a promising therapy. Our aim was to identify transcriptome changes in the acute phase of SCI and the effect of Tamoxifen on those changes in a rat model of SCI. Four groups were considered: (1) Non-injured without TMX (Sham/TMX-), (2) Non-injured with TMX (Sham/TMX+), (3) injured without TMX (SCI/TMX-), and (4) injured with TMX (SCI/TMX+)...
September 13, 2023: Current Issues in Molecular Biology
keyword
keyword
52678
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.