Evgenij Fiskin, Gökcen Eraslan, Maria B Alora-Palli, Juan Manuel Leyva-Castillo, Sean Kim, Heather Choe, Caleb A Lareau, Helena Lau, Emily P Finan, Isabella Teixeira-Soldano, Brenna LaBere, Anne Chu, Brian Woods, Janet Chou, Michal Slyper, Julia Waldman, Sabina Islam, Lynda Schneider, Wanda Phipatanakul, Craig Platt, Orit Rozenblatt-Rosen, Toni M Delorey, Jacques Deguine, Gideon P Smith, Raif Geha, Aviv Regev, Ramnik Xavier
In healthy skin, a cutaneous immune system maintains the balance between tolerance towards innocuous environmental antigens and immune responses against pathological agents. In atopic dermatitis (AD), barrier and immune dysfunction result in chronic tissue inflammation. Our understanding of the skin tissue ecosystem in AD remains incomplete with regard to the hallmarks of pathological barrier formation, and cellular state and clonal composition of disease-promoting cells. Here, we generated a multi-modal cell census of 310,691 cells spanning 86 cell subsets from whole skin tissue of 19 adult individuals, including non-lesional and lesional skin from 11 AD patients, and integrated it with 396,321 cells from four studies into a comprehensive human skin cell atlas in health and disease...
October 31, 2023: bioRxiv