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https://www.readbyqxmd.com/read/29782266/-the-association-of-gene-polymorphisms-of-matrix-metalloproteinases-9-12-and-20-and-collagen-type-i-degradation-products-with-the-remodeling-of-the-left-ventricle-in-patients-with-acute-myocardial-infarction
#1
N A Sokolova, M S Danshova, A V Govorin, D N Zaytsev, Y N Smolyakov
OBJECTIVE: to study associations of polymorphism of the genes MMP9 rs17576, MMP12 rs2276109, MMP20 rs2245803, COL1A1 rs1800012, COL1A1 rs1107946 with remodeling of the left ventricle in patients with acute myocardial infarction. MATERIALS AND METHODS: We examined 84 patients with myocardial infarction (MI). Type of early postinfarction left ventricular (LV) remodeling was determined by echocardiography on the third day of the disease. Concentration of matrix metalloproteinases (MMP) was measured by enzyme immunoassay using commercial kits; content of C-terminal telopeptide of collagen type I degradation products (ICTP) was measured by chemiluminescent immunoassay...
March 2018: Kardiologiia
https://www.readbyqxmd.com/read/29722565/mmp-12-activates-protease-activated-receptor-par-1-upregulates-placenta-growth-factor-and-leads-to-pulmonary-emphysema
#2
Hsin-Han Hou, Hao-Chien Wang, Shih-Lung Cheng, Yen-Fu Chen, Kai-Zen Lu, Chong-Jen Yu
Due to the expansion of aging and smoking populations, chronic pulmonary obstructive disease (COPD) is predicted to be the third leading cause of death worldwide in 2030. It is therefore pertinent to develop effective therapy to improve management for COPD. Cigarette smoke-mediated protease-antiprotease imbalance is a major pathogenic mechanism for COPD and results in massive pulmonary infiltration of neutrophils and macrophages, releasing excessive neutrophil elastase (NE) and matrix metalloproteinases (MMPs)...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29677166/in-vitro-identification-of-new-transcriptomic-and-mirnomic-profiles-associated-with-pulmonary-fibrosis-induced-by-high-doses-everolimus-looking-for-new-pathogenetic-markers-and-therapeutic-targets
#3
Simona Granata, Gloria Santoro, Valentina Masola, Paola Tomei, Fabio Sallustio, Paola Pontrelli, Matteo Accetturo, Nadia Antonucci, Pierluigi Carratù, Antonio Lupo, Gianluigi Zaza
The administration of Everolimus (EVE), a mTOR inhibitor used in transplantation and cancer, is often associated with adverse effects including pulmonary fibrosis. Although the underlying mechanism is not fully clarified, this condition could be in part caused by epithelial to mesenchymal transition (EMT) of airway cells. To improve our knowledge, primary bronchial epithelial cells (BE63/3) were treated with EVE (5 and 100 nM) for 24 h. EMT markers (α-SMA, vimentin, fibronectin) were measured by RT-PCR. Transepithelial resistance was measured by Millicell-ERS ohmmeter...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29625729/corrigendum-to-elevated-20-hete-in-metabolic-syndrome-regulates-arterial-stiffness-and-systolic-hypertension-via-mmp12-activation-j-mol-cell-cardiol-117-2018-88-99
#4
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Jenny Yang, Frank Fan Zhang, Sachindra Raj Joshi, Chastity Bradford, Katherine H Gotlinger, Rachana Maniyar, John R Falck, Spencer Proctor, Michal Laniado Schwartzman, Sachin A Gupte, Petra Rocic
No abstract text is available yet for this article.
April 4, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29616282/a-large-lung-gene-expression-study-identifying-il1b-as-a-novel-player-in-airway-inflammation-in-copd-airway-epithelial-cells
#5
Gao Yi, Min Liang, Ming Li, Xiangming Fang, Jifang Liu, Yuxiong Lai, Jitao Chen, Wenxia Yao, Xiao Feng, La Hu, Chunyi Lin, Xinke Zhou, Zhaoyu Liu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive lung disease characterized by a mixture of small airway disease and lung tissue parenchymal destruction. Abnormal inflammatory responses to cigarette smoking and other noxious particles are generally thought to be responsible for causing of COPD. Since airway inflammation is a key factor in COPD progress, it is crucial to unravel its underlying molecular mechanisms. Unbiased analysis of genome-wide gene expression profiles in lung small airway epithelial cells provides a powerful tool to investigate this...
April 3, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29580202/carcinoembryonic-antigen-as-a-marker-of-radioresistance-in-colorectal-cancer-a-potential-role-of-macrophages
#6
Eng-Yen Huang, Jen-Chieh Chang, Hong-Hwa Chen, Chieh-Ying Hsu, Hsuan-Chih Hsu, Keng-Liang Wu
BACKGROUND: We sought to identify the carcinoembryonic antigen (CEA) as a marker of radioresistance in rectal cancer. METHODS: From July 1997 to January 2008, 104 patients with stage II or III rectal cancer who were treated with post-operative radiotherapy (PORT) were included in this study. The doses of radiotherapy ranged from 45 to 54.6 Gy. The CEA levels were measured before surgery. We analyzed the actuarial rates of overall survival (OS), distant metastasis (DM), and local recurrence (LR) using Kaplan-Meier curves...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29555056/myeloid-derived-suppressor-cells-accumulate-among-myeloid-cells-contributing-to-tumor-growth-in-matrix-metalloproteinase-12-knockout-mice
#7
Jiangchao Li, Xiaohan Zhang, Qing Liu, Mingming Yang, Zijun Zhou, Yuxiang Ye, Zeqi Zhou, Xiaodong He, Lijing Wang
Myeloid-derived suppressor cells (MDSCs) are found frequently in patients and mice bearing tumors, which derived from immature myeloid cells. In healthy individuals, immature myeloid cells formed in the bone marrow differentiating to dendritic cells, macrophages and neutrophils. However, it is unclear whether some gene deficiency will lead to MDSCs accumulation in mice without bearing tumor. Here, we observed that MDSCs accumulated in the bone marrow of matrix metalloproteinase 12 knockout mice (MMP12-/- mice) compared with wild type mice (MMP12+/+ mice)...
December 13, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29543996/human-beta-defensin-3-alters-matrix-metalloproteinase-production-in-human-dendritic-cells-exposed-to-porphyromonas-gingivalis-hemagglutinin-b
#8
Monica Raina, Amber M Bates, Carol L Fischer, Ann Progulske-Fox, Taher Abbasi, Shireen Vali, Kim A Brogden
BACKGROUND: Matrix metalloproteinases (MMPs) are zinc- or calcium-dependent proteinases involved in normal maintenance of extracellular matrix. When elevated, they contribute to the tissue destruction seen in periodontal disease. Recently, we found that human beta defensin 3 (HBD3), a cationic antimicrobial peptide, alters chemokine and proinflammatory cytokine responses in human myeloid dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B (HagB). In this study, the hypotheses that HagB induces MMP production in dendritic cells and that HBD3 mixed with HagB prior to treatment alters HagB-induced MMP profiles were tested...
March 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29527222/age-and-tissue-specific-expression-of-senescence-biomarkers-in-mice
#9
Adam D Hudgins, Cagdas Tazearslan, Archana Tare, Yizhou Zhu, Derek Huffman, Yousin Suh
Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct changes in gene expression and the acquisition of a complex proinflammatory secretory profile termed the senescence-associated secretory phenotype (SASP). Senescent cells accumulate in aged tissues and contribute to age-related disease in mice. Increasing evidence that selective removal of senescent cells can ameliorate diseases of late life and extend lifespan in mice has given rise to the development of senolytics that target senescent cells as anti-aging therapeutics...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29523595/interleukin-3-stimulates-matrix-metalloproteinase-12-production-from-macrophages-promoting-thoracic-aortic-aneurysm-dissection
#10
Chang Liu, Congcong Zhang, Lixin Jia, Boya Chen, Luxin Liu, Jie Sun, Wenmei Zhang, Bin You, Yulin Li, Ping Li, Jie Du
Thoracic aortic aneurysm and dissection (TAAD) is due to degeneration of the aorta and causes a high mortality rate, while molecular mechanisms for the development of TAAD are still not completely understood. In the present study, 3-aminopropionitrile (BAPN) treatment was used to induce TAAD mouse model. Through transcriptome analysis, we found the expression levels of genes associated with interleukin-3 (IL-3) signaling pathway were up-regulated during TAAD development in mouse, which were validated by real-time PCR...
March 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29503085/distinct-requirements-for-extracellular-and-intracellular-mmp12-in-the-development-of-the-adult-v-svz-neural-stem-cell-niche
#11
Xiwei Shan, Lyl Tomlinson, Qian Yang, Holly Colognato
The regulatory mechanisms that control neural stem cell (NSC) activation in the adult ventricular-subventricular zone (V-SVZ) stem cell niche have been the focus of intense investigation, yet how the niche first develops and organizes is poorly understood. Here, we examined matrix metalloproteinases (MMPs) for potential roles in V-SVZ stem cell niche development. MMP12 was found to promote appropriate niche cellular arrangements, the formation of specialized niche extracellular matrix, and the translational planar cell polarity of ependymal cells that surround and support niche NSCs...
March 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29463257/cerium-oxide-and-barium-sulfate-nanoparticle-inhalation-affects-gene-expression-in-alveolar-epithelial-cells-type-ii
#12
Daniela Schwotzer, Monika Niehof, Dirk Schaudien, Heiko Kock, Tanja Hansen, Clemens Dasenbrock, Otto Creutzenberg
BACKGROUND: Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of early biomarkers for potential (sub-)chronic effects of nanoparticles provides a promising approach towards cost-intensive and animal consuming long-term studies. As part of a 90-day inhalation toxicity study with CeO2 NM-212 and BaSO4 NM-220 the present investigations on gene expression and immunohistochemistry should reveal details on underlying mechanisms of pulmonary effects...
February 20, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29458338/association-of-matrix-metalloprotease-1-3-and-12-polymorphisms-with-rheumatic-heart-disease-in-a-chinese-han-population
#13
Wei Hu, Yujia Ye, Yirui Yin, Peng Sang, Linhua Li, Jing Wang, Wen Wan, Rui Li, Xiangfeng Bai, Yuehui Xie, Zhaohui Meng
BACKGROUND: Rheumatic heart disease (RHD) is an autoimmune disease triggered by acute rheumatic fever (ARF). Matrix metalloproteinases (MMPs) play an important role in the modulation of immune responses. The purpose of this study was to evaluate the association of MMP1, 3, and 12 promoter polymorphisms with RHD in a Han population in Southern China since the 3 genes are localized on the same chromosome and have a combined effect. METHODS: DNA samples were obtained from 90 adult patients with RHD and 90 control subjects...
February 20, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29428638/elevated-20-hete-in-metabolic-syndrome-regulates-arterial-stiffness-and-systolic-hypertension-via-mmp12-activation
#14
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Jenny Yang, Frank Fan Zhang, Sachindra Raj Joshi, Chastity Bradford, Katherine H Gotlinger, Rachana Maniyar, John R Falck, Spencer Proctor, Michal Laniado Schwartzman, Sachin A Gupte, Petra Rocic
Arterial stiffness plays a causal role in development of systolic hypertension. 20-hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic acid metabolite, is known to be elevated in resistance arteries in hypertensive animal models and loosely associated with obesity in humans. However, the role of 20-HETE in the regulation of large artery remodeling in metabolic syndrome has not been investigated. We hypothesized that elevated 20-HETE in metabolic syndrome increases matrix metalloproteinase 12 (MMP12) activation leading to increased degradation of elastin, increased large artery stiffness and increased systolic blood pressure...
April 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29422610/coordinated-activation-of-a-cluster-of-mmp-genes-in-response-to-uvb-radiation
#15
Zsuzsanna Ujfaludi, Agota Tuzesi, Hajnalka Majoros, Balint Rothler, Tibor Pankotai, Imre M Boros
Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, we use a novel human keratinocyte model, HKerE6SFM, to demonstrate that UVB activates the transcription of most members of the 11q22.3 MMP gene cluster including MMP13, MMP12, MMP3, MMP1 and MMP10...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29390099/mmp12-82-a-g-promoter-polymorphism-in-bronchial-asthma-in-a-population-of-central-bulgaria
#16
Tanya Tacheva, Dimo Dimov, Elina Aleksandrova, Monika Bialecka, Maya Gulubova, Tatyana Vlaykova
A characteristic feature of inflamed lungs in bronchial asthma (BA) is airway remodeling. Due to limited information on this topic in the literature, we aimed to explore the possible role of polymorphisms in the promoter region of the macrophage elastase gene MMP12 82A>G (rs2276109) as a predisposing factor for BA in an ethnic Bulgarian population. Using restriction fragment length polymorphism analysis of polymerase chain reaction-amplified fragments (PCR-RFLP), we performed genotype analysis of 58 patients and 119 control individuals...
January 30, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29373036/timp3-deficiency-exacerbates-iron-overload-mediated-cardiomyopathy-and-liver-disease
#17
Pavel Zhabyeyev, Subhash K Das, Ratnadeep Basu, Mengcheng Shen, Vaibhav B Patel, Zamaneh Kassiri, Gavin Y Oudit
Chronic iron-overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron-overload. We investigated the role of tissue inhibitor of metalloproteinase-3 (TIMP3) in iron-overload mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3-/- ) and wildtype (WT) mice to 12 weeks of chronic iron-overload. While iron-overload in the WT group developed diastolic dysfunction, iron-overloaded Timp3-/- mice showed worsened cardiac dysfunction coupled with systolic dysfunction...
January 26, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29372477/loss-of-response-to-anti-tumor-necrosis-factor-alpha-therapy-in-crohn-s-disease-is-not-associated-with-emergence-of-novel-inflammatory-pathways
#18
Jay Luther, Manish Gala, Suraj J Patel, Maneesh Dave, Nynke Borren, Ramnik J Xavier, Ashwin N Ananthakrishnan
BACKGROUND: While monoclonal antibodies against tumor necrosis factor-α (TNFα) are effective in treating Crohn's disease (CD), approximately one-third of patients lose response. The mechanisms underlying this loss of response remain elusive. AIM: We sought to determine if novel biological pathways, including TNFα-independent inflammatory pathways, emerge in those with loss of response to anti-TNFα. METHODS: Using RNA microarray technology in 28 patients with CD, we examined the colonic gene expression differences between those with active inflammation in the setting of loss of response to TNFα-antagonist therapy ("loss of responders") compared to anti-TNFα naïve patients with active inflammation and those on anti-TNF therapy in disease remission...
March 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29328428/regulation-of-drug-resistance-and-metastasis-of-gastric-cancer-cells-via-the-microrna647-ank2-axis
#19
Wenlong Cao, Weiyuan Wei, Zexu Zhan, Dongyi Xie, Yubo Xie, Qiang Xiao
Due to a lack of effective methods for early diagnosis, the majority of patients with gastric cancer (GC) are diagnosed during the late stages of the disease, which are often accompanied by metastasis. For these patients, despite being considered an important therapeutic modality in the treatment of cancer, chemotherapy is usually not effective due to multidrug resistance (MDR). The expression levels of MDR/metastasis‑associated genes are regulated by numerous microRNAs (miRNAs/miRs). The expression of miR-647 in GC tissues and SGC7901/VCR cell line (drug resistance to vincristine) was detected by qRT-PCR...
April 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29164621/determining-candidate-single-nucleotide-polymorphisms-in-acquired-laryngotracheal-stenosis
#20
Mursalin M Anis, Natalia Krynetskaia, Zhigen Zhao, Evgeny Krynetskiy, Ahmed M S Soliman
OBJECTIVES/HYPOTHESIS: Despite wide adoption of strategies to prevent injury from prolonged intubation and tracheotomy, acquired laryngotracheal stenosis (ALTS) has not disappeared. ALTS' persistence may be due to patient factors that confer unique susceptibility for some. We sought to identify genetic markers in genes associated with wound healing that could be associated with ALTS. STUDY DESIGN: Case-control study. METHODS: One hundred thirty-eight patients were recruited, 53 patients with ALTS and 85 control patients who underwent intubation or tracheotomy without evidence of ALTS...
March 2018: Laryngoscope
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