keyword
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536980/connective-tissue-disease-associated-interstitial-lung-disease
#2
JOURNAL ARTICLE
Karin Mueller Storrer, Carolina de Souza Müller, Maxwell Cássio de Albuquerque Pessoa, Carlos Alberto de Castro Pereira
Connective tissue disease-associated interstitial lung disease (CTD-ILD) represents a group of systemic autoimmune disorders characterized by immune-mediated organ dysfunction. Systemic sclerosis, rheumatoid arthritis, idiopathic inflammatory myositis, and Sjögren's syndrome are the most common CTDs that present with pulmonary involvement, as well as with interstitial pneumonia with autoimmune features. The frequency of CTD-ILD varies according to the type of CTD, but the overall incidence is 15%, causing an important impact on morbidity and mortality...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536967/uncovering-the-power-of-hsccc-separation-of-diastereomeric-and-regioisomeric-styrylpyrones-from-the-stem-bark-of-goniothalamus-leiocarpus
#3
JOURNAL ARTICLE
Xiao Liu, Ling-Yun Li, Zhi-Qin Zhang, Xiu-Chuan Fu, Rong-Sheng Li, Jia-Li Yao, Simon Gibbons, Qing Mu
The plant Goniothalamus leiocarpus of the Annonaceae family is used as an alternative medicine in tropical regions. Applying high-speed counter current chromatography (HSCCC), eight new bioactive styrylpyrone isomers, including 6 R ,7 S ,8 R ,2' S -goniolactone B ( 1 ), 6 S ,7 S ,8 S ,2' S -goniolactone B ( 2 ), 6 R ,7 R ,8 R ,2' S -goniolactone B ( 3 ), 6 R ,7 S ,8 S ,2' S -goniolactone C ( 4 ), 6 R ,7 S ,8 R ,2' S -goniolactone C ( 5 ), 6 S ,7 R ,8 S ,2' S -goniolactone C ( 6 ), and two positional isomers, 6 R ,7 R ,8 R ,2' S -goniolactone G ( 7 ) and 6 S ,7 R ,8 R ,2' S -goniolactone G ( 8 ), were isolated from a chloroform fraction (2...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#4
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536895/the-read-through-transcription-mediated-autoactivation-circuit-for-virulence-regulator-expression-drives-robust-type-iii-secretion-system-2-expression-in-vibrio-parahaemolyticus
#5
JOURNAL ARTICLE
Dhira Saraswati Anggramukti, Eiji Ishii, Andre Pratama, Mohamad Al Kadi, Tetsuya Iida, Toshio Kodama, Shigeaki Matsuda
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans worldwide. The major virulence factor responsible for the enteropathogenicity of this pathogen is type III secretion system 2 (T3SS2), which is encoded on the 80-kb V. parahaemolyticus pathogenicity island (Vp-PAI), the gene expression of which is governed by the OmpR-family transcriptional regulator VtrB. Here, we found a positive autoregulatory feature of vtrB transcription, which is often observed with transcriptional regulators of bacteria, but the regulation was not canonically dependent on its own promoter...
March 2024: PLoS Pathogens
https://read.qxmd.com/read/38536871/species-specific-responses-during-seoul-orthohantavirus-infection-in-human-and-rat-lung-microvascular-endothelial-cells
#6
JOURNAL ARTICLE
Danny Noack, Mirjam C G N van den Hout, Carmen W E Embregts, Wilfred F J van IJcken, Marion P G Koopmans, Barry Rockx
Seoul orthohantavirus (SEOV) is a rat-borne zoonotic virus that is transmitted via inhalation of aerosolized infectious excreta, and can cause hemorrhagic fever with renal syndrome (HFRS) in humans worldwide. In rats, SEOV predominantly exists as a persistent infection in the absence of overt clinical signs. Lack of disease in rats is attributed to downregulation of pro-inflammatory and upregulation of regulatory host responses. As lung microvascular endothelial cells (LMECs) represent a primary target of infection in both human and rats, infections in these cells provide a unique opportunity to study the central role of LMECs in the dichotomy between pathogenicity in both species...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#7
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536662/natural-killer-group%C3%A2-2d-major-histocompatibility-complex-class%C3%A2-i-polypeptide-related-sequence%C3%A2-a-activation-enhances-natural-killer-cell-mediated-immunity-against-hepatocellular-carcinoma-a-review
#8
REVIEW
Jun Arai, Akinori Okumura, Naoya Kato, Kiyoaki Ito
The recent clinical introduction of immune checkpoint inhibitors has improved therapeutic outcomes in patients with advanced hepatocellular carcinoma. However, these therapies targeting CD8+ T lymphocytes have a response rate of approximately 30%. In addition to CD8+ T lymphocytes, natural killer (NK) cells represent promising therapeutic targets for hepatocellular carcinoma, because they comprise 30%-50% of all lymphocytes in the liver and contribute to antitumor immunity. A recent meta-analysis revealed that the percentage of infiltrating NK cells in hepatocellular carcinoma correlates with a better patient outcome...
March 27, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38536443/a-polo-like-kinase-1-inhibitor-enhances-erastin-sensitivity-in-head-and-neck-squamous-cell-carcinoma-cells-in-vitro
#9
JOURNAL ARTICLE
Xiangping Wu, Jing Wu
BACKGROUND: Polo-like kinase 1 (PLK1) is a critical therapeutic target in the treatment of head and neck squamous cell carcinoma (HNSCC). The objective of this study was to investigate the therapeutic effect of the combination of BI 2536, a PLK1 inhibitor, and erastin, a ferroptosis inducer, in HNSCC. METHODS: The proliferation, invasion, and migration abilities of Tu177 and FaDu cells upon exposure to BI 2536 and erastin, used in combination or alone, were tested...
March 27, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38536434/the-analysis-of-boric-acid-effect-on-epithelial-mesenchymal-transition-of-cd133%C3%A2-%C3%A2-cd117%C3%A2-%C3%A2-lung-cancer-stem-cells
#10
JOURNAL ARTICLE
Tuğba Semerci Sevimli, Murat Sevimli, Aynaz Ghorbani, Varol Şahintürk, Emilia Qomi Ekenel, Tuğba Ertem, Bahar Demir Cevizlidere, Burcugül Altuğ, Özlem Tomsuk, Onur Uysal, Sibel Güneş Bağış, Hüseyin Avci, Fatih Çemrek, Zarifa Ahmadova
Targeting lung cancer stem cells (LC-SCs) for metastasis may be an effective strategy against lung cancer. This study is the first on epithelial-mesenchymal transition (EMT) properties of boric acid (BA) in LC-SCs. LC-SCs were isolated using the magnetic cell sorting (MACS) method. Tumor-sphere formation and flow cytometry confirmed CSC phenotype. The cytotoxic effect of BA was measured by MTT analysis, and the effect of BA on EMT was examined by migration analysis. The expression levels of ZEB1, SNAIL1, ITGA5, CDH1, ITGB1, VIM, COL1A1, and LAMA5 genes were analyzed by RT-qPCR...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536165/high-dimensional-mass-cytometry-reveals-emphysema-associated-changes-in-the-pulmonary-immune-system
#11
JOURNAL ARTICLE
Li Jia, Na Li, Tamim R M Abdelaal, Nannan Guo, Marieke E IJsselstein, Vincent van Unen, Ciska Lindelauf, Qinyue Jiang, Yanling Xiao, M Fernanda Pascutti, Pieter S Hiemstra, Frits Koning, Jan Stolk, P Padmini S J Khedoe
RATIONALE: Chronic inflammation plays an important role in alveolar tissue damage in emphysema, but the underlying immune alterations and cellular interactions are incompletely understood. OBJECTIVE: To explore disease-specific pulmonary immune cell alterations and cellular interactions in emphysema. METHODS: We used single-cell mass cytometry to compare the immune compartment in alveolar tissue from 15 patients with severe emphysema and 5 controls...
March 27, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#12
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38535983/nutritional-profiling-fiber-content-and-in-vitro-bioactivities-of-wheat-based-biscuits-formulated-with-novel-ingredients
#13
JOURNAL ARTICLE
Marta Mesias, Francisco J Morales, Cristina Caleja, Tânia C S P Pires, Ricardo C Calhelha, Lillian Barros, Eliana Pereira
This study evaluated the nutritional profile and fiber content of innovative formulations of wheat-based biscuits enriched with chia seeds, carob flour and coconut sugar. The in vitro antioxidant, cytotoxic, anti-inflammatory and antimicrobial activities were also investigated to understand the potential health advantages of the incorporation of these new ingredients. The novel biscuits demonstrated significant improvements in protein and mineral content, with increases of 50% and 100% in chia biscuits, and up to 20% and 40% in carob biscuits, respectively...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38535922/the-cocktail-effects-on-the-acute-cytotoxicity-of-pesticides-and-pharmaceuticals-frequently-detected-in-the-environment
#14
JOURNAL ARTICLE
Balázs Göbölös, Rózsa E Sebők, Gyula Szabó, Gergő Tóth, Sándor Szoboszlay, Balázs Kriszt, Edit Kaszab, Judit Háhn
Xenobiotics never appear as single, isolated substances in the environment but instead as multi-component mixtures. However, our understanding of the ecotoxicology of mixtures is far from sufficient. In this study, three active pharmaceutical ingredients (carbamazepine, diclofenac, and ibuprofen) and three pesticides (S-metolachlor, terbuthylazine, and tebuconazole) from the most frequently detected emerging micropollutants were examined for their acute cytotoxicity, both individually and in combination, by bioluminescence inhibition in Aliivibrio fischeri (NRRL B-11177)...
February 28, 2024: Toxics
https://read.qxmd.com/read/38535801/hortensins-type-1-ribosome-inactivating-proteins-from-seeds-of-red-mountain-spinach-isolation-characterization-and-their-effect-on-glioblastoma-cells
#15
JOURNAL ARTICLE
Sara Ragucci, Veronica Russo, Angela Clemente, Maria Giuseppina Campanile, Maria Antonietta Oliva, Nicola Landi, Paolo Vincenzo Pedone, Antonietta Arcella, Antimo Di Maro
Ribosome inactivating proteins (RIPs) are specific N-β-glycosylases that are well-characterized in plants. Their enzymatic action is to damage ribosomes, thereby blocking protein translation. Recently, several research groups have been working on the screening for these toxins in edible plants to facilitate the use of RIPs as biotechnological tools and biopesticides and to overcome public prejudice. Here, four novel monomeric (type 1) RIPs have been isolated from the seeds of Atriplex hortensis L. var...
March 4, 2024: Toxins
https://read.qxmd.com/read/38535646/fe-3-o-4-tio-2-microspheres-harnessing-o-2-release-and-ros-generation-for-combination-cdt-pdt-ptt-chemotherapy-in-tumours
#16
JOURNAL ARTICLE
Bo Zhao, Xiuli Hu, Lu Chen, Xin Wu, Donghui Wang, Hongshui Wang, Chunyong Liang
In the treatment of various cancers, photodynamic therapy (PDT) has been extensively studied as an effective therapeutic modality. As a potential alternative to conventional chemotherapy, PDT has been limited due to the low Reactive Oxygen Species (ROS) yield of photosensitisers. Herein, a nanoplatform containing mesoporous Fe3 O4 @TiO2 microspheres was developed for near-infrared (NIR)-light-enhanced chemodynamical therapy (CDT) and PDT. Titanium dioxide (TiO2 ) has been shown to be a very effective PDT agent; however, the hypoxic tumour microenvironment partly affects its in vivo PDT efficacy...
March 10, 2024: Nanomaterials
https://read.qxmd.com/read/38535643/exploring-borate-modified-calcium-phosphate-ceramics-antimicrobial-potential-and-cytocompatibility-assessment
#17
JOURNAL ARTICLE
Inna V Fadeeva, Katia Barbaro, Annalisa Altigeri, Anna A Forysenkova, Marat R Gafurov, Georgy V Mamin, Alexander V Knot'ko, Viktoriya G Yankova, Anna A Zhukova, Fabrizio Russo, Julietta V Rau
Addressing periprosthetic infections, which present significant healing challenges that often require revision surgeries, necessitates the development of novel antibacterial materials and implants. Current research focuses on creating materials that hinder bacterial adhesion, colonization, and proliferation in surrounding tissues. Boron (B)-containing compounds are known for their antibacterial properties and potential in bone metabolism for regenerative medicine. In this study, we synthesized B-containing tricalcium phosphate (0...
March 9, 2024: Nanomaterials
https://read.qxmd.com/read/38535625/targeted-and-self-adjuvated-nanoglycovaccine-candidate-for-cancer-immunotherapy
#18
JOURNAL ARTICLE
Rui Freitas, Eduardo Ferreira, Andreia Miranda, Dylan Ferreira, Marta Relvas-Santos, Flávia Castro, Beatriz Santos, Martina Gonçalves, Sofia Quintas, Andreia Peixoto, Carlos Palmeira, André M N Silva, Lúcio Lara Santos, Maria José Oliveira, Bruno Sarmento, José Alexandre Ferreira
Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not found in healthy human tissues. This presents a valuable approach for designing targeted therapeutics, including cancer glycovaccines, which could potentially promote antigen recognition and foster the immune response to control disease spread and prevent relapse. In this study, we describe an adjuvant-free poly(lactic- co -glycolic acid) (PLGA)-based nanoglycoantigen delivery approach that outperforms conventional methods by eliminating the need for protein carriers while exhibiting targeted and adjuvant properties...
March 27, 2024: ACS Nano
https://read.qxmd.com/read/38535520/isolation-of-two-peptaibols-with-potent-antimicrobial-and-cytotoxic-activities-from-the-mangrove-endophytic-fungus-trichoderma-lentiforme-ml-p8-2
#19
JOURNAL ARTICLE
Yihao Yin, Ge Zhu, Jianying Wu, Zhigang She, Jie Yuan, Bo Wang
Trichorzin PA is a family of 18-residue peptaibols with linear and flexible peptide chains. The three-dimensional structures and biological activities of trichorzin PA peptaibols are largely uncharacterised. In this work, two previously identified peptaibols, trichorzin PA VI ( 1 ) and II ( 2 ), were isolated from Trichoderma lentiforme ML-P8-2. While for the first time, we report here the X-ray crystallographic structure of 1 , antimicrobial activities against a panel of common pathogenic bacteria and fungi, and cytotoxicities of 1 and 2 ...
March 27, 2024: Natural Product Research
https://read.qxmd.com/read/38535495/spironolactone-induces-vasodilation-by-endothelium-dependent-mechanisms-involving-no-and-by-endothelium-independent-mechanisms-blocking-ca-2-channels
#20
JOURNAL ARTICLE
Margarida Lorigo, João Amaro, Elisa Cairrao
BACKGROUND: Spironolactone (SPI) is a diuretic widely used to treat cardiovascular diseases (CVD) and is non-specific for mineralocorticoid receptors (MR) and with an affinity for progesterone (PR) and androgen (AR) receptors. Since 2009, it has been suggested that pharmaceuticals are emerging contaminants (called EDC), and recently, it was reported that most EDC are AR and MR antagonists and estrogen receptors (ER) agonists. Concerning SPI, endocrine-disrupting effects were observed in female western mosquitofish, but there are still no data regarding the SPI effects as a possible human EDC...
March 1, 2024: Journal of Xenobiotics
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