keyword
MENU ▼
Read by QxMD icon Read
search

Cytotoxic

keyword
https://www.readbyqxmd.com/read/29245120/bioactive-polyoxygenated-seco-cyclohexenes-from-artabotrys-hongkongensis
#1
Yan-Ping Liu, Jin-Ying Tang, Yan Hua, Liang Lai, Xiu-Lan Luo, Zhi-Jie Zhang, Wen-Qing Yin, Guang-Ying Chen, Yan-Hui Fu
Six new polyoxygenated seco-cyclohexenes, artahongkongenes A-F (1-6), together with six known analogues (7-12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. New seco-cyclohexenes 1-6 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0...
December 7, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29245062/comparative-studies-on-dna-binding-and-in-vitro-antitumor-activity-of-enantiomeric-ruthenium-ii-complexes
#2
Wen-Xu Hong, Fengwen Huang, Tianwen Huan, Xu Xu, Qingguo Han, Gaofeng Wang, Hong Xu, Shan Duan, Yongheng Duan, Xun Long, Ying Liu, Zhangli Hu
A pair of ruthenium(II) complex enantiomers, Δ- and Λ-[Ru(bpy)2PBIP]2+ {bpy=2,2'-bipyridine, PBIP=2-(4-bromophenyl)imidazo[4,5-f]1,10-phenanthroline} have been synthesized and characterized. The systematic comparative studies between two enantiomers on their DNA binding-behaviors with calf thymus DNA (CT DNA) were carried out by viscosity measurements, spectrophotometric methods and molecular simulation technology. Additional assays were performed to explore the cytotoxicity of the ruthenium(II) enantiomers against tumor cell lines...
November 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29245030/osmotin-a-plant-defense-tool-against-biotic-and-abiotic-stresses
#3
REVIEW
Hakim, Abid Ullah, Amjad Hussain, Muhammad Shaban, Aamir Hamid Khan, Muna Alariqi, Summia Gul, Zhang Jun, Sun Lin, Jianying Li, Shuangxia Jin, Muhammad Farooq Hussain Munis
Plants are prone to a number of pathogens and abiotic stresses that cause various disorders. However, plants possess a defense mechanism to cope with these stresses. The osmotin protein belongs to the PR-5 family of Pathogenesis-related (PR) proteins, which are produced in response to diseases caused by various biotic and abiotic stresses. Osmotin uses a signal transduction pathway to inhibit the activity of defensive cell wall barriers and increases its own cytotoxic efficiency. However, in response to cytotoxic effects, this pathway stimulates a mitogen-activated protein kinase (MAPK) cascade that triggers changes in the cell wall and enables osmotin's entrance into the plasma membrane...
December 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29244869/lspr-mediated-high-axial-resolution-fluorescence-imaging-on-a-silver-nanoparticle-sheet
#4
Eiji Usukura, Yuhki Yanase, Ayumi Ishijima, Thasaneeya Kuboki, Satoru Kidoaki, Koichi Okamoto, Kaoru Tamada
This paper reports our original technique for visualizing cell-attached nanointerfaces with extremely high axial resolution using homogeneously excited localized surface plasmon resonance (LSPR) on self-assembled silver nanoparticle sheets. The LSPR sheet can confine and enhance the fluorescence at the nanointerface, which provides high signal-to-noise ratio images of focal adhesion at the cell-attached interface. The advantage of this LSPR-assisted technique is its usability, which provides comparable or higher-quality nanointerfacial images than TIRF microscopy, even under epifluorescence microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/29244751/spirulina-extract-enhanced-a-protective-effect-in-type-1-diabetes-by-anti-apoptosis-and-anti-ros-production
#5
Jiyeong Lee, Arum Park, Mi Jeong Kim, Hee-Joung Lim, Young-Ah Rha, Hee-Gyoo Kang
Interest in the nutritional value and pharmacological activities of blue-green algae has gradually increased. Spirulina extracts show protective effects against apoptosis and inflammatory damage in various cell types. Here, we investigated the protective effects of extracts from Spirulina maxima in a cytokine-mediated type 1 diabetes model in vitro and in streptozotocin-induced diabetic Wistar rats in vivo. Interleukin-1β and interferon-gamma induced substantial cytotoxicity to RINm5F rat insulinoma cells, increasing nitric oxide (NO) production, nuclear factor-kappa B (NF-κB) activity, the expression of endoplasmic reticulum (ER) stress genes, and activation of mitogen-activated protein kinases and key genes related apoptosis...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244745/immunotherapeutic-potential-of-oncolytic-h-1-parvovirus-hints-of-glioblastoma-microenvironment-conversion-towards-immunogenicity
#6
Assia L Angelova, Milena Barf, Karsten Geletneky, Andreas Unterberg, Jean Rommelaere
Glioblastoma, one of the most aggressive primary brain tumors, is characterized by highly immunosuppressive microenvironment. This contributes to glioblastoma resistance to standard treatment modalities and allows tumor growth and recurrence. Several immune-targeted approaches have been recently developed and are currently under preclinical and clinical investigation. Oncolytic viruses, including the autonomous protoparvovirus H-1 (H-1PV), show great promise as novel immunotherapeutic tools. In a first phase I/IIa clinical trial (ParvOryx01), H-1PV was safe and well tolerated when locally or systemically administered to recurrent glioblastoma patients...
December 15, 2017: Viruses
https://www.readbyqxmd.com/read/29244711/flavonoids-and-ellagitannins-characterization-antioxidant-and-cytotoxic-activities-of-phyllanthus-acuminatus-vahl
#7
Mirtha Navarro, Ileana Moreira, Elizabeth Arnaez, Silvia Quesada, Gabriela Azofeifa, Felipe Vargas, Diego Alvarado, Pei Chen
The phenolic composition of leaves from Phyllanthus acuminatus L., a plant commonly used in Costa Rica as traditional medicine, was studied using UPLC-ESI-MS on an enriched phenolic extract. A total of 20 phenolic compounds were identified, comprising eight flavonoids (two flavanones-pinocembrin isomers and six derivatives from apigenin, chrysin, quercetin, and kaempferol); seven ellagitannins, two flavan-3-ols (prodelphinidin B dimer and (epi)gallocatechin); and three phenolic acids (ellagic acid, trimethylellagic acid, and ferulic acid)...
December 15, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29244608/safety-and-efficacy-of-intralesional-triamcinolone-administration-for-treatment-of-mast-cell-tumors-in-dogs-23-cases-2005-2011
#8
Ashley Case, Kristine Burgess
OBJECTIVE To evaluate the safety and efficacy of intralesional triamcinolone administration, as a sole or adjuvant treatment, in dogs with mast cell tumors. DESIGN Retrospective case series ANIMALS 23 dogs with mast cell tumors. PROCEDURES Medical records of dogs treated for a confirmed diagnosis of a mast cell tumor between 2005 and 2011 were reviewed. Patients with a confirmed diagnosis and measurable disease (tumor longest dimension ≥ 0.5 cm) that had received ≥ 1 intralesional treatment with triamcinolone, regardless of prior, concurrent, or adjuvant treatments, were eligible for inclusion...
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29244495/antiprotozoal-sesquiterpene-lactones-and-other-constituents-from-tarchonanthus-camphoratus-and-schkuhria-pinnata
#9
Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt
In continuation of a search for new antiprotozoal agents from plants of the family Asteraceae, Tarchonanthus camphoratus and Schkuhria pinnata have been investigated. By following the promising in vitro activity of the dichloromethane extracts from their aerial parts, bioassay-guided chromatographic isolation yielded two known sesquiterpene lactones (1 and 2) from T. camphoratus and 20 known compounds of this type from S. pinnata. From the latter, a new eudesmanolide, (1R*,5S*,6R*,7R*,8R*,10R*)-1-hydroxy-8-[5″-hydroxy-4'-(2″-hydroxyisovaleroyloxy)tigloyloxy]-3-oxoeudesma-11(13)-en-6,12-olide (3), and two new germacranolides, 3β-(2″-hydroxyisovaleroyloxy)-8β-(3-furoyloxy)costunolide (14) and 1(10)-epoxy-3β-hydroxy-8β-[5'-hydroxy-4'-(2″-hydroxyisovaleroyloxy)tigloyloxy]costunolide (16), were obtained...
December 15, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29244487/synergistic-inhibitory-effect-of-gqds-tramiprosate-covalent-binding-on-amyloid-aggregation
#10
Yibiao Liu, Li-Ping Xu, Qiang Wang, Baocheng Yang, Xueji Zhang
Inhibiting the amyloid aggregation is considered to be an effective strategy to explore possible treatment of amyloid-related diseases including Alzheimer's disease, Parkinson's disease, and type II diabetes. Herein, a new high-efficiency and low-cytotoxicity Aβ aggregation inhibitors, GQD-T was designed through the combination of two Aβ inhibitors graphene quantum dots (GQDs) and tramiprosate. GQD-T showed the capability of efficiently inhibiting the aggregation of Aβ peptides and rescuing Aβ-induced cytotoxicity due to the synergistic effect of the GQDs and tramiprosate...
December 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29244249/flow-cytometric-false-myeloperoxidase-positive-childhood-b-lineage-acute-lymphoblastic-leukemia
#11
Süreyya Savaşan, Steven Buck, Manisha Gadgeel, Ali Gabali
BACKGROUND: Flow cytometric intracellular myeloperoxidase (MPO) staining of leukemic blasts is a useful tool in diagnosis of leukemia subtype. Interpretation of high MPO-positivity can be a diagnostic challenge in B-lineage acute lymphoblastic leukemia (B-ALL). While very few such cases have been reported, high MPO positive B-ALL cases without additional myeloid antigen positivity are suspect and require further investigation. METHODS: Three pediatric cases of B-ALL with strong MPO staining (clone 8E6; Invitrogen) at diagnosis and three others with negative MPO staining were studied by flow cytometry and immunohistochemistry...
December 15, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29243967/extracts-of-porphyra-tenera-nori-seaweed-activate-the-immune-response-in-mouse-raw264-7-macrophages-via-nf-%C3%AE%C2%BAb-signaling
#12
Ji-Hye Song, Hee-Bum Kang, Seung-Ho Park, Ji-Hoon Jeong, Jeongjin Park, Yanghee You, Yoo-Hyun Lee, Jeongmin Lee, Eungpil Kim, Kyung-Chul Choi, Woojin Jun
Porphyra tenera, also known as nori, is a red algal species of seaweed. It is cultivated in Asia for culinary purposes. We report that P. tenera extract (PTE) enhances the immune response in mouse macrophages. We found that P. tenera extract regulates the NF-κB IκB kinase (IKK) signaling pathway, and we assessed the expression and translocation of p65, a subunit of NF-κB, in RAW264.7 mouse macrophage cells after treatment with PTE. We also investigated the effects of 10% ethanol PTE (PTE10) in RAW264.7 cells...
December 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29243926/antibacterial-activity-of-nitric-oxide-releasing-hyperbranched-polyamidoamines
#13
Lei Yang, Xingzhi Wang, Dakota J Suchyta, Mark H Schoenfisch
Hyperbranched polyamidoamines (h-PAMAM) were prepared using a one-pot reaction to have similar molecular weight to third generation PAMAM (G3-PAMAM) dendrimers, and then functionalized with N-diazeniumdiolate nitric oxide (NO) donors. A wide range of NO storage capacities (∼1-2.50 μmol mg-1) and NO-release kinetics (t1/2 ∼30-80 min) were achieved by changing the extent of propylene oxide (PO) modification. The therapeutic potential of these materials was evaluated by studying their antibacterial activities and toxicity against common dental pathogens and human gingival fibroblast cells, respectively...
December 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29243925/in-vitro-bypass-of-thymidine-glycol-by-dna-polymerase-%C3%AE-forms-sequence-dependent-frameshift-mutations
#14
Daniel J Laverty, Marc M Greenberg
Unrepaired DNA lesions block replication and threaten genomic stability. Several specialized translesion polymerases, including polymerase θ (Pol θ), contribute to replicative bypass of these lesions. The role of Pol θ in double-strand break repair is well-understood, but its contribution to translesion synthesis is much less so. We describe the action of Pol θ on templates containing thymidine glycol (Tg), a major cytotoxic, oxidative DNA lesion that blocks DNA replication. Unrepaired Tg lesions are bypassed in human cells by specialized translesion polymerases by one of two distinct pathways: high-fidelity bypass by the combined action of Pol κ and Pol ζ or weakly mutagenic bypass by Pol θ...
December 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29243919/zinc-ii-metalated-porphyrins-as-photothermogenic-photosensitizers-for-cancer-photodynamic-photothermal-synergistic-therapy
#15
Kaikai Ding, Ye-Wei Zhang, Weili Si, Xiangmin Zhong, Yu Cai, Jianhua Zou, Jinjun Shao, Zhou Yang, Xiaochen Dong
Porphyrin derivatives are the first-generation photosensitizers, and to design a strong NIR-absorbing porphyrin with good water solubility is highly desired for better therapeutic effect to treat tumors. Herein, three new porphyrin derivatives, 5,10,15,20-tetrakis(3,4- dimethoxyphenyl) porphyrin (P1), 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) Zinc porphyrin (ZnP1), and 5,15-bis (3,4-dimethoxyphenyl)-10,20-bis ((4-methoxyphenyl)ethynyl) Zinc porphyrin (ZnP2) have been synthesized. Among them, ZnP2 shows the longest and most intensive Q-bands in the near-infrared (NIR) region, as endows it the strongest light-harvesting capability and deepest tumor tissue penetration...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29243872/binding-affinity-and-in-vitro-cytotoxicity-of-harmaline-targeting-different-motifs-of-nucleic-acids-an-ultimate-drug-designing-approach
#16
Paromita Bhattacharjee, Tapas Ghosh, Sarita Sarkar, Prateek Pandya, Kakali Bhadra
The work focuses towards interaction of harmaline, with nucleic acids of different motifs by multispectroscopic and calorimetric techniques. Findings of this study suggest that binding constant varied in the order single-stranded (ss) poly(A) > double-stranded calf thymus (CT) DNA > double-stranded poly(G)·poly(C) > clover leaf tRNAPhe . Prominent structural changes of ss poly(A), CT DNA, and poly(G)· poly(C) with concomitant induction of optical activity in the bound achiral alkaloid molecule was observed, while with tRNAPhe , very weak induced circular dichroism perturbation was seen...
December 15, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29243757/musa-paradisiaca-inflorescence-induces-human-colon-cancer-cell-death-by-modulating-cascades-of-transcriptional-events
#17
Arun K B, Aravind Madhavan, Reshmitha T R, Sithara Thomas, P Nisha
Colorectal cancer (CRC) is one of the leading causes of cancer death, and diet plays an important role in the etiology of CRC. Traditional medical practitioners in many South Asian countries use plantain inflorescence to treat various gastro-intestinal ailments. The aim of the present study was to investigate the anticancer effects of extracts of inflorescence of Musa paradisiaca against HT29 human colon cancer cells and elucidate the mechanism of these effects by studying the modulation of cascades of transcriptional events...
December 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29243578/design-synthesis-and-in-vitro-anti-microbial-evaluation-of-ethylene-propylene-1h-1-2-3-triazole-4-methylene-tethered-isatin-coumarin-hybrids
#18
Xiaohong Jin, Yan Xu, Xuhong Yang, Xiuling Chen, Minghu Wu, Jianguo Guan, Lianshun Feng
A new class of ethylene/propylene-1H-1,2,3-triazole-4-methylene-tethered isatin-coumarin hybrids 8a-j, integrate three anti-tuberculosis pharmacophores coumarin, isatin and 1,2,3-triazole was designed and synthesized. These hybrids were assessed for their in vitro anti-TB activity against MTB H37Rv and MDR-TB, as well as anti-bacterial activity against Gram-positive and Gram-negative strains, and cytotoxicity in VERO cell line. The results showed that all hybrids with acceptable cytotoxicity (CC50: 64-512 μg/mL) exhibited weak to moderate anti-microbial activity...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29243545/the-role-of-macrophages-in-the-differentiation-process-of-ureteral-polyps
#19
Yue-Hui Wang, Tian-Qi Zhang, Ji-Ning Fu, Ying Liu, Hai-Yan Jia
Objective To evaluate the role of macrophage infiltration in the differentiation process of ureteral polyps and cancers. Methods This retrospective immunohistochemical study analysed archival samples of pathologically-confirmed specimens of low- and high-grade ureteral cancer, ureteral papilloma and ureteral polyps. The samples were immunohistochemically stained for cluster of differentiation (CD)4, CD8, CD16, CD25, CD56 and CD68 using immunofluorescence in order to identify different T-lymphocyte populations and macrophages...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29243515/alkaloids-from-juglans-mandshurica-maxim-induce-distinctive-cell-death-in-hepatocellular-carcinoma-cells
#20
Li-Li Lou, Zhuo-Yang Cheng, Rui Guo, Guo-Dong Yao, Shao-Jiang Song
The aim of this work was to further investigate the anticancer potential of Juglans mandshurica Maxim, including the separation of active constituents and their anti-proliferative effects with underlying mechanism of action. Five alkaloids (1-5) were isolated from the bark of J. mandshurica. Among them, 1 showed the highest cytotoxic activities against Hep3B and HepG2 cells with an IC50 values of 61.80 and 56.24 μM, respectively. Therefore, the cellular mechanism involved 1 was subsequently studied. Our results showed that 1 markedly caused apoptosis and autophagy, but without cell cycle arrest in HepG2 cells...
December 15, 2017: Natural Product Research
keyword
keyword
52676
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"