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Lamis Baydoun, Fook Chang Lam, Sontje Schaal, Shugi Hsien, Silke Oellerich, Korine van Dijk, Gerrit R J Melles
PURPOSE: To assess aqueous flare as a measure of subclinical inflammation after Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy. METHODS: In this prospective cross-sectional and longitudinal case series at a tertiary referral center, 173 DMEK eyes of 169 patients and 19 age-matched healthy control eyes were included. Aqueous flare [photon count per millisecond (ph/ms)] was assessed by laser flare photometry at 1 day, 1 week, and 1 month after DMEK in group I (evaluation of postsurgical blood-aqueous barrier recovery; n = 25) and on average 28 (±19) months (range, 3-86 months) after DMEK in group II (evaluation of long-term inflammation; n = 148)...
March 15, 2018: Cornea
Julian C Berengut, Dmitry Budker, Cédric Delaunay, Victor V Flambaum, Claudia Frugiuele, Elina Fuchs, Christophe Grojean, Roni Harnik, Roee Ozeri, Gilad Perez, Yotam Soreq
We explore a method to probe new long- and intermediate-range interactions using precision atomic isotope shift spectroscopy. We develop a formalism to interpret linear King plots as bounds on new physics with minimal theory inputs. We focus only on bounding the new physics contributions that can be calculated independently of the standard model nuclear effects. We apply our method to existing Ca^{+} data and project its sensitivity to conjectured new bosons with spin-independent couplings to the electron and the neutron using narrow transitions in other atoms and ions, specifically, Sr and Yb...
March 2, 2018: Physical Review Letters
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Jochen Börgermann, Stefan Pilz
PURPOSE: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients. METHODS: In a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations < 75 nmol/L the effect of a daily vitamin D3 supplement of 4000 IU for 3 years (n = 71) vs...
March 15, 2018: European Journal of Nutrition
Martin Dübbers, Elena Nikolaou, Hans Fuchs, Janina Fischer, Hakan Alakus, Jessica Leers, Christiane Bruns, Grigore Cernaianu
BACKGROUND: Transumbilical laparoscopic-assisted appendectomy (TULAA) is fast and cost-effective since no endoloops, staplers or wound protection devices are used. We analyzed the effects of TULAA as first approach for perforated (PA) and non-perforated (NPA) appendicitis in children. PATIENTS: We performed a retrospective analysis of 181 children for whom TULAA was the first approach for appendicitis between October 2010 and March 2016. METHODS: Morbidity, additional laparoscopic instrument insertion (AI), conversions to open extraumbilical appendectomy (OC), and complications were evaluated...
March 15, 2018: Klinische Pädiatrie
Charles S Fuchs, Toshihiko Doi, Raymond W Jang, Kei Muro, Taroh Satoh, Manuela Machado, Weijing Sun, Shadia I Jalal, Manish A Shah, Jean-Phillipe Metges, Marcelo Garrido, Talia Golan, Mario Mandala, Zev A Wainberg, Daniel V Catenacci, Atsushi Ohtsu, Kohei Shitara, Ravit Geva, Jonathan Bleeker, Andrew H Ko, Geoffrey Ku, Philip Philip, Peter C Enzinger, Yung-Jue Bang, Diane Levitan, Jiangdian Wang, Minori Rosales, Rita P Dalal, Harry H Yoon
Importance: Therapeutic options are needed for patients with advanced gastric cancer whose disease has progressed after 2 or more lines of therapy. Objective: To evaluate the safety and efficacy of pembrolizumab in a cohort of patients with previously treated gastric or gastroesophageal junction cancer. Design, Setting, and Participants: In the phase 2, global, open-label, single-arm, multicohort KEYNOTE-059 study, 259 patients in 16 countries were enrolled in a cohort between March 2, 2015, and May 26, 2016...
March 15, 2018: JAMA Oncology
Nika Abdollahi, Alexandre Albani, Eric Anthony, Agnes Baud, Mélissa Cardon, Robert Clerc, Dariusz Czernecki, Romain Conte, Laurent David, Agathe Delaune, Samia Djerroud, Pauline Fourgoux, Nadège Guiglielmoni, Jeanne Laurentie, Nathalie Lehmann, Camille Lochard, Rémi Montagne, Vasiliki Myrodia, Vaitea Opuu, Elise Parey, Lélia Polit, Sylvain Privé, Chloé Quignot, Maria Ruiz-Cuevas, Mariam Sissoko, Nicolas Sompairac, Audrey Vallerix, Violaine Verrecchia, Marc Delarue, Raphael Guérois, Yann Ponty, Sophie Sacquin-Mora, Alessandra Carbone, Christine Froidevaux, Stéphane Le Crom, Olivier Lespinet, Martin Weigt, Samer Abboud, Juliana Bernardes, Guillaume Bouvier, Chloé Dequeker, Arnaud Ferré, Patrick Fuchs, Gaëlle Lelandais, Pierre Poulain, Hugues Richard, Hugo Schweke, Elodie Laine, Anne Lopes
We present a new educational initiative called Meet-U that aims to train students for collaborative work in computational biology and to bridge the gap between education and research. Meet-U mimics the setup of collaborative research projects and takes advantage of the most popular tools for collaborative work and of cloud computing. Students are grouped in teams of 4-5 people and have to realize a project from A to Z that answers a challenging question in biology. Meet-U promotes "coopetition," as the students collaborate within and across the teams and are also in competition with each other to develop the best final product...
March 2018: PLoS Computational Biology
Michael Fuchs, Ruizhi Liu, Ivan Malagoli Lanzoni, Goran Munivrana, Gunter Straub, Sho Tamaki, Kazuto Yoshida, Hui Zhang, Martin Lames
In table tennis, many different approaches to scientific founded match analysis have been developed since the first ones in the 1960s. The aim of this paper is to give a review on some of the most acknowledged methods of match analysis in table tennis. The first chapter presents a historical overview of match analysis from all over the world. The second part reviews different approaches to match analysis in more detail, using the performance analysis classification of theoretical and practical performance analysis...
March 15, 2018: Journal of Sports Sciences
M G Aartsen, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, I Al Samarai, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, C Argüelles, J Auffenberg, S Axani, H Bagherpour, X Bai, J P Barron, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, D Berley, E Bernardini, D Z Besson, G Binder, D Bindig, E Blaufuss, S Blot, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Bourbeau, F Bradascio, J Braun, L Brayeur, M Brenzke, H-P Bretz, S Bron, J Brostean-Kaiser, A Burgman, T Carver, J Casey, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, R Cross, M Day, J P A M de André, C De Clercq, J J DeLaunay, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, P Eller, P A Evenson, S Fahey, A R Fazely, J Felde, K Filimonov, C Finley, S Flis, A Franckowiak, E Friedman, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, K Ghorbani, W Giang, T Glauch, T Glüsenkamp, A Goldschmidt, J G Gonzalez, D Grant, Z Griffith, C Haack, A Hallgren, F Halzen, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, B Hokanson-Fasig, K Hoshina, F Huang, M Huber, K Hultqvist, M Hünnefeld, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, P Kalaczynski, W Kang, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, A Kheirandish, J Kim, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, L Köpke, C Kopper, S Kopper, J P Koschinsky, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, A Kyriacou, M Labare, J L Lanfranchi, M J Larson, F Lauber, D Lennarz, M Lesiak-Bzdak, M Leuermann, Q R Liu, L Lu, J Lünemann, W Luszczak, J Madsen, G Maggi, K B M Mahn, S Mancina, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, T Menne, G Merino, T Meures, S Miarecki, J Micallef, G Momenté, T Montaruli, R W Moore, M Moulai, R Nahnhauer, P Nakarmi, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, P Peiffer, J A Pepper, C Pérez de Los Heros, D Pieloth, E Pinat, M Plum, P B Price, G T Przybylski, C Raab, L Rädel, M Rameez, K Rawlins, I C Rea, R Reimann, B Relethford, M Relich, E Resconi, W Rhode, M Richman, S Robertson, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, T Sälzer, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, S Sarkar, K Satalecka, P Schlunder, T Schmidt, A Schneider, S Schoenen, S Schöneberg, L Schumacher, D Seckel, S Seunarine, J Soedingrekso, D Soldin, M Song, G M Spiczak, C Spiering, J Stachurska, M Stamatikos, T Stanev, A Stasik, J Stettner, A Steuer, T Stezelberger, R G Stokstad, A Stößl, N L Strotjohann, G W Sullivan, M Sutherland, I Taboada, J Tatar, F Tenholt, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, C F Tung, A Turcati, C F Turley, B Ty, E Unger, M Usner, J Vandenbroucke, W Van Driessche, N van Eijndhoven, S Vanheule, J van Santen, M Vehring, E Vogel, M Vraeghe, C Walck, A Wallace, M Wallraff, F D Wandler, N Wandkowsky, A Waza, C Weaver, M J Weiss, C Wendt, J Werthebach, S Westerhoff, B J Whelan, K Wiebe, C H Wiebusch, L Wille, D R Williams, L Wills, M Wolf, J Wood, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, T Yuan, M Zoll
We present a measurement of the atmospheric neutrino oscillation parameters using three years of data from the IceCube Neutrino Observatory. The DeepCore infill array in the center of IceCube enables the detection and reconstruction of neutrinos produced by the interaction of cosmic rays in Earth's atmosphere at energies as low as ∼5  GeV. That energy threshold permits measurements of muon neutrino disappearance, over a range of baselines up to the diameter of the Earth, probing the same range of L/E_{ν} as long-baseline experiments but with substantially higher-energy neutrinos...
February 16, 2018: Physical Review Letters
Ursula J Lemberger, Claudia D Fuchs, Christian Schöfer, Andrea Bileck, Christopher Gerner, Tatjana Stojakovic, Makoto M Taketo, Michael Trauner, Gerda Egger, Christoph H Österreicher
Background: Wnt/β-catenin signaling plays a crucial role in embryogenesis, tissue homeostasis, metabolism and malignant transformation of different organs including the liver. Continuous β-catenin signaling due to somatic mutations in exon 3 of the Ctnnb1 gene is associated with different liver diseases including cancer and cholestasis. Results: Expression of a degradation resistant form of β-catenin in hepatocytes resulted in 100% mortality within 31 days after birth...
February 16, 2018: Oncotarget
Shigeru Kinoshita, Noriko Koizumi, Morio Ueno, Naoki Okumura, Kojiro Imai, Hiroshi Tanaka, Yuji Yamamoto, Takahiro Nakamura, Tsutomu Inatomi, John Bush, Munetoyo Toda, Michio Hagiya, Isao Yokota, Satoshi Teramukai, Chie Sotozono, Junji Hamuro
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density. METHODS: We performed an uncontrolled, single-group study involving 11 persons who had received a diagnosis of bullous keratopathy and had no detectable CECs...
March 15, 2018: New England Journal of Medicine
Chen Qu, Dandan Zheng, Sai Li, Yingjun Liu, Anna Lidofsky, Jacinta A Holmes, Jianning Chen, Lu He, Lan Wei, Yadi Liao, Hui Yuan, Qimeng Jin, Zelong Lin, Qiaoting Hu, Yuchuan Jiang, Mengxian Tu, Xijun Chen, Weiming Li, Wenyu Lin, Bryan C Fuchs, Raymond T Chung, Jian Hong
Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has been reported as a novel biomarker for human hepatocellular carcinoma (HCC). We sought to investigate the mechanism by which SYK promotes liver fibrosis and to evaluate SYK as a therapeutic target for liver fibrosis. We evaluated the cellular localization of SYK and the association between SYK expression and liver fibrogenesis in normal, HBV-infected, HCV-infected and non-alcoholic steatohepatitis (NASH) liver tissue (n=36, 127, 22 and 30, respectively)...
March 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Fabiola Fuchs, Martin Robausch
BACKGROUND: The topic of "medical oversupply at the end-of-life" is being discussed intensively internationally. The aim of this paper is to present the data of end-of-life care in one region in Austria (Lower Austria). METHODS: The data basis for the end-of-life indicators was the routine data (secondary data analysis) of the Lower Austrian District Health Insurance Fund (NÖGKK) from 2015. The basic population consisted of persons with inpatient hospitalization with a cancer diagnosis...
March 13, 2018: Wiener Medizinische Wochenschrift
H F Fuchs, D T Müller, F Berlth, M K Maus, C Fuchs, M Dübbers, W Schröder, C J Bruns, J M Leers
24-hour esophageal pH-metry is not designed to detect laryngopharyngeal reflux (LPR). The new laryngopharyngeal pH-monitoring system (Restech) may detect LPR better. There is no established correlation between these two techniques as only small case series exist. The aim of this study is to examine the correlation between the two techniques with a large patient cohort. All patients received a complete diagnostic workup for gastroesophageal reflux including symptom evaluation, endoscopy, 24-hour pH-metry, high resolution manometry, and Restech...
March 8, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
F Andrea Sass, Michael Fuchs, Matthias Pumberger, Sven Geissler, Georg N Duda, Carsten Perka, Katharina Schmidt-Bleek
Soft tissue trauma of skeletal muscle is one of the most common side effects in surgery. Muscle injuries are not only caused by accident-related injuries but can also be of an iatrogenic nature as they occur during surgical interventions when the anatomical region of interest is exposed. If the extent of trauma surpasses the intrinsic regenerative capacities, signs of fatty degeneration and formation of fibrotic scar tissue can occur, and, consequentially, muscle function deteriorates or is diminished. Despite research efforts to investigate the physiological healing cascade following trauma, our understanding of the early onset of healing and how it potentially determines success or failure is still only fragmentary...
March 13, 2018: International Journal of Molecular Sciences
Fatima Padilla-Cabal, Dietmar Georg, Hermann Fuchs
PURPOSE: The feasibility of Magnetic Resonance Image (MRI) based proton therapy is based, among several other factors, on the implementation of appropriate extensions on current dose calculation methods. This work aims to develop a pencil beam algorithm (PBA) for dose calculation of proton beams within magnetic field regions of up to 3T. METHODS: Monte Carlo (MC) simulations using the GATE 7.1/GEANT4.9.4p02 toolkit were performed to generate calibration and benchmarking data for the PBA...
March 12, 2018: Medical Physics
Marcel Fuchs, Cecilia Stanghellini
Current research seeking to relate between ambient water vapor deficit (D) and foliage conductance (gF ) derives a canopy conductance (gW ) from measured transpiration by inverting the coupled transpiration model to yield gW  = m - n ln(D) where m and n are fitting parameters. In contrast, this paper demonstrates that the relation between coupled gW and D is gW  = AP/D + B, where P is the barometric pressure, A is the radiative term, and B is the convective term coefficient of the Penman-Monteith equation...
March 12, 2018: International Journal of Biometeorology
Carsten Goebel, Thomas L Diepgen, Brunhilde Blömeke, Anthony A Gaspari, Axel Schnuch, Anne Fuchs, Kordula Schlotmann, Maya Krasteva, Ian Kimber
Occupational exposure of hairdressers to hair dyes has been associated with the development of allergic contact dermatitis (ACD) involving the hands. p-Phenylenediamine (PPD) and toluene-2,5-diamine (PTD) have been implicated as important occupational contact allergens. To conduct a quantitative risk assessment for the induction of contact sensitization to hair dyes in hairdressers, available data from hand rinsing studies following typical occupational exposure conditions to PPD, PTD and resorcinol were assessed...
March 9, 2018: Regulatory Toxicology and Pharmacology: RTP
Richard J Wood, Carlos A Reck-Burneo, Daniel Dajusta, Christina Ching, Rama Jayanthi, D Gregory Bates, Molly E Fuchs, Katherine McCracken, Geri Hewitt, Marc A Levitt
No abstract text is available yet for this article.
March 2018: Journal of Pediatric Surgery
Johanna M Gostner, Eva Obermayr, Ioana E Braicu, Nicole Concin, Sven Mahner, Adriaan Vanderstichele, Jalid Sehouli, Ignace Vergote, Dietmar Fuchs, Robert Zeillinger
OBJECTIVE: Circulating tumor cells (CTCs) may represent a chronic stimulus for the immune system. In the present study we investigated the potential association of CTCs, the immune activation marker neopterin, and the ratio of kynurenine to tryptophan (Kyn/Trp) as a measure for tryptophan breakdown. METHODS: Neopterin, tryptophan and kynurenine levels were measured in plasma samples from patients with benign gynecological diseases (n=65) and with primary advanced epithelial ovarian cancer (EOC) at diagnosis (n=216) and six months after adjuvant platinum-based chemotherapy (n=45) by an enzyme-linked immunosorbent assay and high performance liquid chromatography...
March 9, 2018: Gynecologic Oncology
Camille Sauvageot, Jean-Michel Faure, Eve Mousty, Anaïg Flandrin, Dominique Forgues, Olivier Prodhomme, Florent Fuchs
OBJECTIVES: The aim of this study was to evaluate the prevalence, the prenatal and postnatal evolution of isolated fetal splenic cysts. METHODS: All cases of suspected fetal splenic cyst or abdominal unidentified cyst discovered during routine ultrasound scan, from 2007 to 2017, and referred to a French tertiary care Center, were retrospectively collected. For each case, several prenatal parameters and postnatal evolution were reported. RESULTS: Among 5450 cases of fetal anomalies, 14 patients (0...
March 12, 2018: Prenatal Diagnosis
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