keyword
https://read.qxmd.com/read/38534545/applications-of-imaging-technologies-in-fuchs-endothelial-corneal-dystrophy-a-narrative-literature-review
#1
REVIEW
Sang Beom Han, Yu-Chi Liu, Chang Liu, Jodhbir S Mehta
Fuchs endothelial corneal dystrophy (FECD) is a complex genetic disorder characterized by the slow and progressive degeneration of corneal endothelial cells. Thus, it may result in corneal endothelial decompensation and irreversible corneal edema. Moreover, FECD is associated with alterations in all corneal layers, such as thickening of the Descemet membrane, stromal scarring, subepithelial fibrosis, and the formation of epithelial bullae. Hence, anterior segment imaging devices that enable precise measurement of functional and anatomical changes in the cornea are essential for the management of FECD...
March 11, 2024: Bioengineering
https://read.qxmd.com/read/38494521/deep-learning-for-detection-of-fuchs-endothelial-dystrophy-from-widefield-specular-microscopy-imaging-a-pilot-study
#2
JOURNAL ARTICLE
Valencia Hui Xian Foo, Gilbert Y S Lim, Yu-Chi Liu, Hon Shing Ong, Evan Wong, Stacy Chan, Jipson Wong, Jodhbir S Mehta, Daniel S W Ting, Marcus Ang
BACKGROUND: To describe the diagnostic performance of a deep learning (DL) algorithm in detecting Fuchs endothelial corneal dystrophy (FECD) based on specular microscopy (SM) and to reliably detect widefield peripheral SM images with an endothelial cell density (ECD) > 1000 cells/mm2 . METHODS: Five hundred and forty-seven subjects had SM imaging performed for the central cornea endothelium. One hundred and seventy-three images had FECD, while 602 images had other diagnoses...
March 18, 2024: Eye and Vision (London, England)
https://read.qxmd.com/read/38471010/comparative-analysis-of-tomographic-indicators-forecasting-decompensation-in-fuchs-endothelial-corneal-dystrophy
#3
JOURNAL ARTICLE
Maria Laura Passaro, Matteo Airaldi, Chiara Ancona, Rosangela Cucco, Ciro Costagliola, Francesco Semeraro, Vito Romano
PURPOSE: To compare the performance of 3 commercially available tomographers (the Pentacam Scheimpflug camera, the swept-source optical coherence tomography Casia, and the blue light slit-scanning tomographer Precisio) in the identification of patterns associated with Fuchs endothelial corneal dystrophy (FECD) decompensation. METHODS: This was a clinic-based cross-sectional imaging study. Pachymetry maps and posterior surface elevation maps were acquired with the 3 devices from 61 eyes affected by FECD...
March 8, 2024: Cornea
https://read.qxmd.com/read/38398752/enhanced-monofocal-intraocular-lenses-in-fuchs-endothelial-dystrophy-patients-results-from-triple-descemet-membrane-endothelial-keratoplasty-procedure
#4
JOURNAL ARTICLE
Rita Mencucci, Giovanni Romualdi, Chiara De Vitto, Michela Cennamo
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) is currently regarded as the most effective surgical procedure for addressing Fuchs Endothelial Corneal Dystrophy (FECD), frequently performed in conjunction with cataract surgery. In this retrospective study, we present a comparison of visual performance, clinical outcomes, and optical quality between two types of monofocal Intraocular Lenses (IOLs): one standard and one enhanced intermediate vision model, implanted in patients who underwent combined phacoemulsification and DMEK surgery...
February 9, 2024: Life
https://read.qxmd.com/read/38391241/differences-in-guttae-ultramorphology-in-relation-to-visual-function-in-fuchs-endothelial-corneal-dystrophy
#5
JOURNAL ARTICLE
Julia M Weller, Maximilian Bennemann, Theofilos Tourtas, Friedrich E Kruse, Ursula Schlötzer-Schrehardt
PURPOSE: The purpose of this study was to investigate the differences in guttae ultramorphology and their relation to visual function in eyes with Fuchs endothelial corneal dystrophy (FECD). METHODS: Thirty FECD eyes without ocular comorbidities were included. Visual functional parameters (best-corrected visual acuity with high-contrast and low-contrast letters and contrast sensitivity/LogCS) and corneal morphology measured with Scheimpflug tomography (Pentacam) were assessed...
February 23, 2024: Cornea
https://read.qxmd.com/read/38369232/long-noncoding-rna-zfas1-a-novel-anti-apoptotic-target-in-fuchs-endothelial-corneal-dystrophy
#6
JOURNAL ARTICLE
Jini Qiu, Ruiping Gu, Qian Shi, Xueling Zhang, Jiayu Gu, Jun Xiang, Jianjiang Xu, Yujing Yang, Kun Shan
Fuchs endothelial corneal dystrophy (FECD) is the leading cause of endothelial keratoplasty without efficacious drug treatment. Recent studies have emphasized the involvement of epigenetic regulation in FECD development. Long non-coding RNAs (lncRNAs) are recognized as crucial epigenetic regulators in diverse cellular processes and ocular diseases. In this study, we revealed the expression patterns of lncRNAs using high-throughput sequencing technology in FECD mouse model, and identified 979 significantly dysregulated lncRNAs...
February 17, 2024: Experimental Eye Research
https://read.qxmd.com/read/38345780/fuchs-endothelial-corneal-dystrophy-an-updated-review
#7
REVIEW
Francisco Altamirano, Gustavo Ortiz-Morales, Mario A O'Connor-Cordova, Juan Pablo Sancén-Herrera, Judith Zavala, Jorge E Valdez-Garcia
PURPOSE: The present review will summarize FECD-associated genes and pathophysiology, diagnosis, current  therapeutic approaches, and future treatment perspectives. METHODS: Literature review. RESULTS: Fuchs' endothelial corneal dystrophy (FECD) is the most common bilateral corneal dystrophy and accounts for one-third of all corneal transplants performed in the US. FECD is caused by a combination of genetic and non-heritable factors, and there are two types: early-onset FECD, which affects individuals from an early age and is usually more severe, and late-onset FECD, which is more common and typically manifests around the age of 40...
February 12, 2024: International Ophthalmology
https://read.qxmd.com/read/38339172/fuch-s-endothelial-corneal-dystrophy-in-cataract-patients-is-associated-with-elevated-levels-of-inflammatory-chemokines-but-not-growth-factors-in-the-aqueous-humor
#8
JOURNAL ARTICLE
Rafał Fiolka, Edward Wylęgała, Michał Toborek, Dominika Szkodny, Zenon Czuba, Adam Wylęgała
The study investigated a profile of chemokines and growth factors in the aqueous humor (AH) of eyes with Fuch's endothelial corneal dystrophy (FECD) and cataracts in comparison with cataract patients as a control group. A total of 52 AH samples (26 FECD + cataract and 26 cataract/control) were collected before cataract surgery. None of the patients had any clinically apparent inflammation at the time of AH collection. The AH levels of MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β(CCL4), RANTES (CCL5), eotaxin (CCL11), IP-10 (CXCL10), FGF basic, G-CSF, GM-CSF, PDGF-bb, and VEGF were compared between the groups...
February 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38337570/predicting-long-term-endothelial-cell-loss-after-preloaded-descemet-membrane-endothelial-keratoplasty-in-fuchs-endothelial-corneal-dystrophy-a-mathematical-model
#9
JOURNAL ARTICLE
Pietro Viola, Enrico Neri, Tommaso Occhipinti, Mohit Parekh, Roberto Cian, Diego Ponzin, Antonio Moramarco, Alfonso Iovieno
(1) Background : This study offers a biexponential model to estimate corneal endothelial cell decay (ECD) following preloaded "endothelium-in" Descemet membrane endothelial keratoplasty (DMEK) in Fuchs' endothelial corneal dystrophy (FECD) patients; (2) Methods : A total of 65 eyes undergoing DMEK alone or combined with cataract surgery were evaluated. The follow-up period was divided into an early phase (first 6 months) and a late phase (up to 36 months). Endothelial cell count (ECC) and endothelial cell loss (ECL) were analyzed; (3) Results : The half time of the ECD was 3...
February 2, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38334475/assessing-fuchs-corneal-endothelial-dystrophy-using-artificial-intelligence-derived-morphometric-parameters-from-specular-microscopy-images
#10
JOURNAL ARTICLE
Angelica M Prada, Fernando Quintero, Kevin Mendoza, Virgilio Galvis, Alejandro Tello, Lenny A Romero, Andres G Marrugo
PURPOSE: The aim of this study was to evaluate the efficacy of artificial intelligence-derived morphometric parameters in characterizing Fuchs corneal endothelial dystrophy (FECD) from specular microscopy images. METHODS: This cross-sectional study recruited patients diagnosed with FECD, who underwent ophthalmologic evaluations, including slit-lamp examinations and corneal endothelial assessments using specular microscopy. The modified Krachmer grading scale was used for clinical FECD classification...
February 9, 2024: Cornea
https://read.qxmd.com/read/38251647/comparison-of-pre-and-post-dmek-keratometry-and-total-keratometry-values-for-iol-power-calculations-in-eyes-undergoing-triple-dmek
#11
JOURNAL ARTICLE
Neal Rangu, David L Cooke, Aman Mittal, Thomas Reinhard, Katrin Wacker, Achim Langenbucher, Jascha A Wendelstein, Kamran M Riaz
PURPOSE: To evaluate prediction accuracy of pre- and post-DMEK keratometry (K) and total keratometry (TK) values for IOL power calculations in Fuchs endothelial corneal dystrophy (FECD) eyes undergoing DMEK with cataract surgery (triple DMEK). METHODS: Retrospective cross-sectional multicenter study of 55 FECD eyes (44 patients) that underwent triple DMEK between 2019 and 2022 between two centers in USA and Europe. Swept-source optical coherence tomography biometry (IOLMaster 700) was used for pre- and post-DMEK measurements...
January 22, 2024: Current Eye Research
https://read.qxmd.com/read/38230632/electron-lock-manipulates-the-catalytic-selectivity-of-nanozyme
#12
JOURNAL ARTICLE
Guopeng Xu, Kehan Liu, Bingqing Jia, Zhenzhen Dong, Chengmei Zhang, Xiangdong Liu, Yuanyuan Qu, Weifeng Li, Mingwen Zhao, Huiting Zhou, Yong-Qiang Li
Nanomaterials with enzyme-mimicking functions, termed nanozymes, offer attractive opportunities for biocatalysis and biomedicine. However, manipulating nanozyme selectivity poses an insurmountable hurdle. Here, we propose the concept of an energy-governed electron lock that controls electron transfer between nanozyme and substrates to achieve selectivity manipulation of enzyme-like catalysis. An electron lock can be constructed and opened, via modulating the nanozyme's electron energy to match the energy barrier of enzymatic reactions...
January 17, 2024: ACS Nano
https://read.qxmd.com/read/38206443/ctg18-1-expansion-in-transcription-factor-4-tcf4-in-corneal-graft-failure-preliminary-study
#13
JOURNAL ARTICLE
Ida Maria Westin, Andreas Viberg, Irina Golovleva, Berit Byström
Fuchs endothelial corneal dystrophy (FECD) is caused by a corneal endothelial cell loss, leading to corneal edema and visual impairment. The most significant genetic risk factor for FECD is an expansion of the CTG18.1 locus in transcription factor 4 (TCF4). The current treatment for severe FECD is corneal transplantation, with Descemet stripping automated keratoplasty (DSAEK) as a common surgical method. Although successful in most cases, the risk for transplant failure due to diverse causes must be considered...
January 11, 2024: Cell and Tissue Banking
https://read.qxmd.com/read/38096202/transcriptomic-meta-analysis-reveals-err%C3%AE-mediated-oxidative-phosphorylation-is-downregulated-in-fuchs-endothelial-corneal-dystrophy
#14
JOURNAL ARTICLE
Xunzhi Zhang, Ashwani Kumar, Adwait A Sathe, V Vinod Mootha, Chao Xing
BACKGROUND: Late-onset Fuchs' endothelial corneal dystrophy (FECD) is a degenerative disease of cornea and the leading indication for corneal transplantation. Genetically, FECD patients can be categorized as with (RE+) or without (RE-) the CTG trinucleotide repeat expansion in the transcription factor 4 gene. The molecular mechanisms underlying FECD remain unclear, though there are plausible pathogenic models proposed for RE+ FECD. METHOD: In this study, we performed a meta-analysis on RNA sequencing datasets of FECD corneal endothelium including 3 RE+ datasets and 2 RE- datasets, aiming to compare the transcriptomic profiles of RE+ and RE- FECD...
2023: PloS One
https://read.qxmd.com/read/38091879/estrogen-genotoxicity-causes-preferential-development-of-fuchs-endothelial-corneal-dystrophy-in-females
#15
JOURNAL ARTICLE
Varun Kumar, Neha Deshpande, Mohit Parekh, Raymond Wong, Shazia Ashraf, Muhammad Zahid, Hanna Hui, Annie Miall, Sylvie Kimpton, Marianne O Price, Francis W Price, Frank J Gonzalez, Eleanor Rogan, Ula V Jurkunas
Fuchs endothelial corneal dystrophy (FECD) is a genetically complex, age-related, female-predominant disorder characterized by loss of post-mitotic corneal endothelial cells (CEnCs). Ultraviolet-A (UVA) light has been shown to recapitulate the morphological and molecular changes seen in FECD to a greater extent in females than males, by triggering CYP1B1 upregulation in females. Herein, we investigated the mechanism of greater CEnC susceptibility to UVA in females by studying estrogen metabolism in response to UVA in the cornea...
February 2024: Redox Biology
https://read.qxmd.com/read/38034859/non-apoptotic-regulated-cell-death-in-fuchs-endothelial-corneal-dystrophy
#16
JOURNAL ARTICLE
Saki Sakakura, Emi Inagaki, Tomoko Sayano, Risa Yamazaki, Noemi Fusaki, Shin Hatou, Masatoshi Hirayama, Kazuo Tsubota, Kazuno Negishi, Hideyuki Okano, Shigeto Shimmura
INTRODUCTION: Fuchs endothelial corneal dystrophy (FECD) is the leading cause of corneal blindness in developed countries. Corneal endothelial cells in FECD are susceptive to oxidative stress, leading to mitochondrial dysfunction and cell death. Oxidative stress causes many forms of cell death including parthanatos, which is characterized by translocation of apoptosis-inducing factor (AIF) to the nucleus with upregulation of poly (ADP-ribose) polymerase 1 (PARP-1) and poly (ADP-ribose) (PAR)...
December 2023: Regenerative Therapy
https://read.qxmd.com/read/38024683/targeting-the-expanded-tcf4-fuchs-endothelial-corneal-dystrophy-cug-repeat-with-morpholino-peptide-conjugates
#17
JOURNAL ARTICLE
Jiaxin Hu, Xiulong Shen, Mahboubeh Kheirabadi, Matthew D Streeter, Ziqing Qian, V Vinod Mootha, David R Corey
Fuchs' corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective curative treatment, but this surgery has limitations. A pharmacological intervention would complement surgery and be beneficial for many patients. FECD is caused by an expanded CUG repeat within intron 2 of the TCF4 RNA. Agents that recognize the expanded repeat can reverse the splicing defects associated with the disease. Successful drug development will require diverse strategies for optimizing the efficacy of anti-CUG oligomers...
November 14, 2023: ACS Omega
https://read.qxmd.com/read/38007433/descemet-membrane-endothelial-keratoplasty-combined-with-presbyopia-correcting-and-toric-intraocular-lenses-a-narrative-review
#18
REVIEW
Marina Rodríguez-Calvo-de-Mora, Carlos Rocha-de-Lossada, Vito Romano, Manuel Rodríguez-Vallejo, Joaquín Fernández
Fuchs endothelial corneal dystrophy (FECD) is the leading indication for EK and may coexist with cataract and presbyopia. Notably, the outcomes of phacoemulsification in FECD patients are not as favorable as those in eyes without this condition. Historically, only monofocal intraocular lenses (IOLs) were recommended for these patients. However, recent reports have described the implantation of Premium-IOLs (such as Multifocal IOLs, Enhanced Depth of Focus IOLs, and Toric IOLs) in FECD eyes undergoing cataract surgery and Descemet membrane endothelial keratoplasty (DMEK)...
November 25, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37962528/endoplasmic-reticulum-stress-disrupts-mitochondrial-bioenergetics-dynamics-and-causes-corneal-endothelial-cell-apoptosis
#19
JOURNAL ARTICLE
Saba Qureshi, Stephanie Lee, William Steidl, Lukas Ritzer, Michael Parise, Ananya Chaubal, Varun Kumar
PURPOSE: Endoplasmic reticulum (ER) and mitochondrial stress are independently associated with corneal endothelial cell (CEnC) loss in many corneal diseases, including Fuchs' endothelial corneal dystrophy (FECD). However, the role of ER stress in mitochondrial dysfunction contributing to CEnC apoptosis is unknown. The purpose of this study is to explore the crosstalk between ER and mitochondrial stress in CEnC. METHODS: Human corneal endothelial cell line (HCEnC-21T) and human corneal endothelial tissues were treated with ER stressor tunicamycin...
November 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37943281/functionalized-fe-doped-carbon-dots-exhibiting-dual-glutathione-consumption-to-amplify-ferroptosis-for-enhanced-cancer-therapy
#20
JOURNAL ARTICLE
Mingyue Zhou, Ziwei Yang, Tianpeng Yin, Yunfeng Zhao, Cai-Yun Wang, Guo-Yuan Zhu, Li-Ping Bai, Zhi-Hong Jiang, Wei Zhang
Nonapoptotic ferroptosis is a promising cancer treatment which offers a solution to the multidrug resistance of conventional apoptosis-induced programmed cancer cell death therapies. Reducing intracellular glutathione (GSH) is essential for inducing excess ROS and has been considered a crucial process to trigger ferroptosis. However, treatments reducing GSH alone have not produced satisfactory effects due to their restricted target. In this regard, FeCDs (Fe3+ -modified l-histidine -sourced carbon dots) with dual GSH-consumption capabilities were constructed to engineer ferroptosis by self-amplifying intratumoral oxidative stress...
November 9, 2023: ACS Applied Materials & Interfaces
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