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deep transcranial magnetic stimulation

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https://www.readbyqxmd.com/read/28208601/surgical-neurostimulation-for-spinal-cord-injury
#1
REVIEW
Aswin Chari, Ian D Hentall, Marios C Papadopoulos, Erlick A C Pereira
Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI...
February 10, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28156250/efficacy-of-deep-rtms-for-neuropathic-pain-in-the-lower-limb-a-randomized-double-blind-crossover-trial-of-an-h-coil-and-figure-8-coil
#2
Takeshi Shimizu, Koichi Hosomi, Tomoyuki Maruo, Yuko Goto, Masaru Yokoe, Yu Kageyama, Toshio Shimokawa, Toshiki Yoshimine, Youichi Saitoh
OBJECTIVE Electrical motor cortex stimulation can relieve neuropathic pain (NP), but its use requires patients to undergo an invasive procedure. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) using a figure-8 coil can relieve NP noninvasively, but its ability to relieve lower limb pain is still limited. Deep rTMS using an H-coil can effectively stimulate deep brain regions and has been widely used for the treatment of various neurological diseases; however, there have been no clinical studies comparing the effectiveness of figure-8 coils and H-coils...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28145409/treatment-of-bipolar-depression-with-deep-tms-dtms-results-from-a-double-blind-randomized-parallel-group-sham-controlled-clinical-trial
#3
Diego F Tavares, Martin L Myczkowski, Rodrigo L Alberto, Leandro Valiengo, Rosa M Rios, Pedro Gordon, Bernardo de Sampaio-Junior, Izio Klein, Carlos G Mansur, Marco Antonio Marcolin, Beny Lafer, Ricardo A Moreno, Wagner Gattaz, Jeff Z Daskalakis, André R Brunoni
Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H1-coil) transcranial magnetic stimulation (dTMS) is a novel TMS modality with established efficacy for unipolar depression. We conducted a randomized sham-controlled trial to evaluate the efficacy and safety of dTMS in treatment-resistant BD patients. Patients received 20 sessions of active or sham dTMS over the left dorsolateral prefrontal cortex (H1-coil, 55 18 Hz 2-sec 120% MT trains). The primary outcome was changes in the 17-item Hamilton Depression Rating Scale (HDRS-17) from baseline to endpoint (week 4)...
February 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28090806/randomised-sham-controlled-study-of-high-frequency-bilateral-deep-transcranial-magnetic-stimulation-dtms-to-treat-adult-attention-hyperactive-disorder-adhd-negative-results
#4
Yaniv Paz, Keren Friedwald, Yeheal Levkovitz, Abraham Zangen, Uri Alyagon, Uri Nitzan, Aviv Segev, Hagai Maoz, May Koubi, Yuval Bloch
OBJECTIVES: Recent studies support the possible effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for attention deficit hyperactivity disorder (ADHD). The objective of this study was to evaluate the safety and possible efficacy of bilateral prefrontal deep rTMS for the treatment of adult ADHD. METHODS: Twenty-six adult ADHD patients were randomised blindly to sham or actual deep TMS (dTMS). Twenty daily sessions were conducted using the bilateral H5 dTMS coil (Brainsway, IL) in order to stimulate the prefrontal cortex at 120% of the motor threshold at high frequency...
January 31, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28055126/neuromodulation-therapies-for-alcohol-addiction-a-literature-review
#5
REVIEW
Celeste A Azevedo, Antonios Mammis
OBJECTIVES: The goal of this review is to explore alternative neurological therapies in the treatment of alcohol use disorder; including transcranial direct current stimulation (tDCS), transcranial magnetic stimulation, deep brain stimulation (DBS), electroconvulsive therapy (ECT), and the off-label use of the GABAB receptor agonist baclofen. METHODS: A comprehensive literature search was conducted through EBSCOhost regarding the neurological therapies in the treatment of alcoholism discussed in this paper...
January 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28030740/repetitive-transcranial-magnetic-stimulation-for-the-acute-treatment-of-major-depressive-episodes-a-systematic-review-with-network-meta-analysis
#6
Andre R Brunoni, Anna Chaimani, Adriano H Moffa, Lais B Razza, Wagner F Gattaz, Zafiris J Daskalakis, Andre F Carvalho
Importance: Although several strategies of repetitive transcranial magnetic stimulation (rTMS) have been investigated as treatment of major depressive disorder (MDD), their comparative efficacy and acceptability is unknown. Objective: To establish the relative efficacy and acceptability of the different modalities of rTMS used for MDD by performing a network meta-analysis, obtaining a clinically meaningful treatment hierarchy. Data Sources: PubMed/MEDLINE, EMBASE, PsycInfo, and Web of Science were searched up until October 1, 2016...
February 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/27799898/globus-pallidus-interna-in-tourette-syndrome-decreased-local-activity-and-disrupted-functional-connectivity
#7
Gong-Jun Ji, Wei Liao, Yang Yu, Huan-Huan Miao, Yi-Xuan Feng, Kai Wang, Jian-Hua Feng, Yu-Feng Zang
Globus pallidus interna (GPi) is an effective deep brain stimulation site for the treatment of Tourette syndrome (TS), and plays a crucial role in the pathophysiology of TS. To investigate the functional network feature of GPi in TS patients, we retrospectively studied 24 boys with 'pure' TS and 32 age-/education-matched healthy boys by resting state functional magnetic resonance images. Amplitude of low-frequency fluctuation (ALFF) and functional connectivity were used to estimate the local activity in GPi and its functional coordinate with the whole brain regions, respectively...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27771287/subthalamic-stimulation-and-levodopa-modulate-cortical-reactivity-in-parkinson-s-patients
#8
Elias Paolo Casula, Mario Stampanoni Bassi, Maria Concetta Pellicciari, Viviana Ponzo, Domenica Veniero, Antonella Peppe, Livia Brusa, Paolo Stanzione, Carlo Caltagirone, Alessandro Stefani, Giacomo Koch
BACKGROUND: The effects of deep brain stimulation of the subthalamic nucleus (DBS-STN) and L-dopa (LD) on cortical activity in Parkinson's disease (PD) are poorly understood. OBJECTIVES: By combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) we explored the effects of STN-DBS, either alone or in combination with L-Dopa (LD), on TMS-evoked cortical activity in a sample of implanted PD patients. METHODS: PD patients were tested in three clinical conditions: i) LD therapy with STN-DBS turned on (ON/ON condition); ii) without LD therapy with STN-DBS turned on (OFF/ON condition); iii) without LD therapy with STN-DBS turned off (OFF/OFF condition)...
January 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27768049/treating-clinical-depression-with-repetitive-deep-transcranial-magnetic-stimulation-using-the-brainsway-h1-coil
#9
David Feifel, Katherine Pappas
Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-pharmacological approach to treating many brain-based disorders. rTMS uses electromagnetic coils to stimulate areas of the brain non-invasively. Deep transcranial magnetic stimulation (dTMS) with the Brainsway H1-coil system specifically is a type of rTMS indicated for treating patients with major depressive disorder (MDD) who are resistant to medication. The unique H1-coil design of this device is able to stimulate neuronal pathways that lie deeper in the targeted brain areas than those reached by conventional rTMS coils...
October 4, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27608482/model-driven-analysis-of-eyeblink-classical-conditioning-reveals-the-underlying-structure-of-cerebellar-plasticity-and-neuronal-activity
#10
Alberto Antonietti, Claudia Casellato, Egidio D'Angelo, Alessandra Pedrocchi
The cerebellum plays a critical role in sensorimotor control. However, how the specific circuits and plastic mechanisms of the cerebellum are engaged in closed-loop processing is still unclear. We developed an artificial sensorimotor control system embedding a detailed spiking cerebellar microcircuit with three bidirectional plasticity sites. This proved able to reproduce a cerebellar-driven associative paradigm, the eyeblink classical conditioning (EBCC), in which a precise time relationship between an unconditioned stimulus (US) and a conditioned stimulus (CS) is established...
September 1, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27601183/deep-transcranial-magnetic-stimulation-dtms-beyond-depression
#11
Aron Tendler, Noam Barnea Ygael, Yiftach Roth, Abraham Zangen
Deep transcranial magnetic stimulation (dTMS) utilizes different H-coils to study and treat a variety of psychiatric and neurological conditions with identifiable brain targets. The availability of this technology is dramatically changing the practice of psychiatry and neurology as it provides a safe and effective way to treat even drug-resistant patients. However, up until now, no effort was made to summarize the different types of H-coils that are available, and the conditions for which they were tested. Areas covered: Here we assembled all peer reviewed publication that used one of the H-coils, together with illustrations of the effective field they generate within the brain...
October 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27590719/consecutive-tms-fmri-reveals-remote-effects-of-neural-noise-to-the-occipital-face-area
#12
Lily M Solomon-Harris, Sara A Rafique, Jennifer K E Steeves
The human cortical system for face perception comprises a network of connected regions including the middle fusiform gyrus ("fusiform face area" or FFA), the inferior occipital gyrus ("occipital face area" or OFA), and the posterior superior temporal sulcus (pSTS). Here, we sought to investigate how transcranial magnetic stimulation (TMS) to the OFA affects activity within the face processing network. We used offline repetitive TMS to temporarily introduce neural noise in the right OFA in healthy subjects. We then immediately performed functional magnetic resonance imaging (fMRI) to measure changes in blood oxygenation level dependent (BOLD) signal across the face network using an fMR-adaptation (fMR-A) paradigm...
November 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27524960/longitudinal-changes-in-depressive-circuitry-in-response-to-neuromodulation-therapy
#13
Yagna Pathak, Oludamilola Salami, Sylvain Baillet, Zhimin Li, Christopher R Butson
BACKGROUND: Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study aims to test whether the brain regions previously targeted by deep brain stimulation (DBS) in the treatment of MDD respond to rTMS, and whether functional connectivity (FC) measures can predict clinical response...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27515029/therapies-for-parkinson-s-diseases-alternatives-to-current-pharmacological-interventions
#14
Song Li, Jie Dong, Cheng Cheng, Weidong Le
Parkinson's disease (PD) is the second most common neurodegenerative disorder caused by the selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although PD has been heavily researched, the precise etiology and pathogenesis for PD are still inconclusive. Consequently, current pharmacological treatments for PD are largely symptomatic rather than preventive and there is still no cure for this disease nowadays. Moreover, nonmotor symptoms caused by intrinsic PD pathology or side effects induced by currently used pharmacological interventions are gaining increasing attention and urgently need to be treated due to their influence on quality of life...
November 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27511815/ean-guidelines-on-central-neurostimulation-therapy-in-chronic-pain-conditions
#15
G Cruccu, L Garcia-Larrea, P Hansson, M Keindl, J-P Lefaucheur, W Paulus, R Taylor, V Tronnier, A Truini, N Attal
BACKGROUND AND PURPOSE: Our aim was to update previous European Federation of Neurological Societies guidelines on neurostimulation for neuropathic pain, expanding the search to new techniques and to chronic pain conditions other than neuropathic pain, and assessing the evidence with the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. METHODS: A systematic review and meta-analysis of trials published between 2006 and December 2014 was conducted...
October 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27509086/paired-pulse-tms-and-fine-wire-recordings-reveal-short-interval-intracortical-inhibition-and-facilitation-of-deep-multifidus-muscle-fascicles
#16
Hugo Massé-Alarie, Edith Elgueta Cancino, Cyril Schneider, Paul Hodges
OBJECTIVE: Paired-pulse transcranial magnetic stimulation (ppTMS) is used to probe inhibitory and excitatory networks within the primary motor cortex (M1). These mechanisms are identified for limb muscles but it is unclear whether they share properties with trunk muscles. The aim was to determine whether it was possible to test the intracortical inhibition and facilitation of the deep multifidus muscle fascicles (DM) and at which inter-stimulus intervals (ISI). METHODS: In ten pain-free individuals, TMS was applied over M1 and motor evoked potentials (MEP) were recorded using fine-wire electrodes in DM...
2016: PloS One
https://www.readbyqxmd.com/read/27486154/canadian-network-for-mood-and-anxiety-treatments-canmat-2016-clinical-guidelines-for-the-management-of-adults-with-major-depressive-disorder-section-4-neurostimulation-treatments
#17
Roumen V Milev, Peter Giacobbe, Sidney H Kennedy, Daniel M Blumberger, Zafiris J Daskalakis, Jonathan Downar, Mandana Modirrousta, Simon Patry, Fidel Vila-Rodriguez, Raymond W Lam, Glenda M MacQueen, Sagar V Parikh, Arun V Ravindran
BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses...
September 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27450744/the-efficacy-of-cerebellar-vermal-deep-high-frequency-theta-range-repetitive-transcranial-magnetic-stimulation-rtms-in-schizophrenia-a-randomized-rater-blind-sham-controlled-study
#18
Shobit Garg, Vinod Kumar Sinha, Sai Krishna Tikka, Preeti Mishra, Nishant Goyal
Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic for schizophrenia. Treatment effects of rTMS have been variable across different symptom clusters, with negative symptoms showing better response, followed by auditory hallucinations. Cerebellum, especially vermis and its abnormalities (both structural and functional) have been implicated in cognitive, affective and positive symptoms of schizophrenia. rTMS to this alternate site has been suggested as a novel target for treating patients with this disorder...
September 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27447245/seizure-induced-by-deep-transcranial-magnetic-stimulation-in-an-adolescent-with-depression
#19
Kathryn R Cullen, Suzanne Jasberg, Brent Nelson, Bonnie Klimes-Dougan, Kelvin O Lim, Paul E Croarkin
OBJECTIVE: Deep transcranial magnetic stimulation (TMS) with an H-1 coil was recently approved by the U.S. Food and Drug Administration (U.S. FDA) for treatment-resistant depression (TRD) in adults. Studies assessing the safety and effectiveness of deep TMS in adolescent TRD are lacking. The purpose of this brief report is to provide a case history of an adolescent enrolled in an investigational deep TMS protocol. METHODS: A case history is described of the first participant of a sham-controlled clinical trial who had a seizure in the course of deep TMS with parameter settings extrapolated from the adult studies that led to US FDA approval (H-1 coil, 120% target stimulation intensity, 18 Hz, 55 trains of 2-second duration, total 1980 pulses)...
September 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27442267/neurostimulation-techniques-in-the-treatment-of-nicotine-dependence-a-review
#20
REVIEW
Fady Rachid
OBJECTIVE: Nicotine dependence accounts for significant mortality, morbidity, and socio-economic burdens. It remains a significant public health concern since it is among the leading causes of mortality worldwide and of preventable deaths in developed countries. Despite the availability of approved medications to treat nicotine dependence, along with cognitive behavioral therapy, only 6% of the total number of smokers who report wanting to quit each year are successful in doing so for more than a month mostly with poor abstinence rates...
September 2016: American Journal on Addictions
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