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https://www.readbyqxmd.com/read/29115915/neuromodulation-in-multiple-sclerosis
#1
Hesham Abboud, Eddie Hill, Junaid Siddiqui, Alessandro Serra, Benjamin Walter
Neuromodulation, or the utilization of advanced technology for targeted electrical or chemical neuronal stimulation or inhibition, has been expanding in several neurological subspecialties. In the past decades, immune-modulating therapy has been the main focus of multiple sclerosis (MS) research with little attention to neuromodulation. However, with the recent advances in disease-modifying therapies, it is time to shift the focus of MS research to neuromodulation and restoration of function as with other neurological subspecialties...
November 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29098676/physical-therapy
#2
Li-Jun Xiao, Ran Tao
Physical therapy has the evidence-based science knowledge to address a wide range of physical and psychological problems of addiction. Neuromodulation techniques are becoming more and more important in the treatment of addiction. Here, the efficacy of different neuromodulation techniques in addiction, such as transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), deep brain stimulation (DBS), is critically evaluated. Other physical therapy methods including Biofeedback, Physical Activity and Acupuncture are also presented...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29032089/transcranial-magnetic-stimulation-in-basic-and-clinical-neuroscience-a-comprehensive-review-of-fundamental-principles-and-novel-insights
#3
REVIEW
Antoni Valero-Cabré, Julià L Amengual, Chloé Stengel, Alvaro Pascual-Leone, Olivier A Coubard
Non-invasive brain stimulation methods, such as Transcranial Magnetic Stimulation (TMS), are widely used worldwide to make causality-based inferences about brain-behavior interactions. TMS-based clinical applications have been shown promising to treat neurological or psychiatric diseases. TMS works by inducing non-invasively electric currents in localized cortical regions thus modulating their excitability levels and ongoing activity patterns depending on stimulation settings: frequency, number of pulses, train duration and intertrain intervals...
October 13, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28990199/the-epigenetic-component-of-the-brain-response-to-electromagnetic-stimulation-in-parkinson-s-disease-patients-a-literature-overview
#4
REVIEW
Claudia Consales, Caterina Merla, Carmela Marino, Barbara Benassi
Modulations of epigenetic machinery, namely DNA methylation pattern, histone modification, and non-coding RNAs expression, have been recently included among the key determinants contributing to Parkinson's Disease (PD) aetiopathogenesis and response to therapy. Along this line of reasoning, a set of experimental findings are highlighting the epigenetic-based response to electromagnetic (EM) therapies used to alleviate PD symptomatology, mainly Deep Brain Stimulation (DBS) and Transcranial Magnetic Stimulation (TMS)...
October 9, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28988547/systematic-review-of-the-efficacy-of-non-pharmacological-interventions-in-people-with-lewy-body-dementia
#5
Hamilton Morrin, Ton Fang, Donald Servant, Dag Aarsland, Anto P Rajkumar
BACKGROUND: Pharmacological interventions for Lewy body dementia (LBD), especially for its non-cognitive symptoms, are limited in their efficacy and tolerability. Clinicians are often uncertain about non-pharmacological interventions and their efficacy in managing cognitive and non-cognitive symptoms of LBD. Therefore, we aimed to systematically review the existing literature on non-pharmacological interventions for people with LBD. METHODS: We carried out a systematic search using six databases...
October 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28969932/targeted-neural-network-interventions-for-auditory-hallucinations-can-tms-inform-dbs
#6
Joseph J Taylor, John H Krystal, Deepak C D'Souza, Jason Lee Gerrard, Philip R Corlett
The debilitating and refractory nature of auditory hallucinations (AH) in schizophrenia and other psychiatric disorders has stimulated investigations into neuromodulatory interventions that target the aberrant neural networks associated with them. Internal or invasive forms of brain stimulation such as deep brain stimulation (DBS) are currently being explored for treatment-refractory schizophrenia. The process of developing and implementing DBS is limited by symptom clustering within psychiatric constructs as well as a scarcity of causal tools with which to predict response, refine targeting or guide clinical decisions...
September 29, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28953851/is-there-potential-for-repetitive-transcranial-magnetic-stimulation-rtms-as-a-treatment-of-ocd
#7
Rashid Zaman, Trevor W Robbins
Obsessive-Compulsive Disorder (OCD) is a common and highly debilitating psychiatric disorder. Amongst OCD sufferers are a significant number (40-60%) of so-called non-responders who do not fully respond to commonly available treatments, which include medications (Selective Serotonin Reuptake Inhibitors-SSRIs) and cognitive behavior therapy (CBT). Modern 'neuromodulatory' techniques such as Deep Brain Stimulation (DBS), repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS) potentially offer alternative forms of treatment for OCD patients who either do not respond to, or are unable or unwilling to take SSRIs and undergo CBT...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28938143/contribution-of-transcranial-magnetic-stimulation-to-assessment-of-brain-connectivity-and-networks
#8
REVIEW
Mark Hallett, Riccardo Di Iorio, Paolo Maria Rossini, Jung E Park, Robert Chen, Pablo Celnik, Antonio P Strafella, Hideyuki Matsumoto, Yoshikazu Ugawa
The goal of this review is to show how transcranial magnetic stimulation (TMS) techniques can make a contribution to the study of brain networks. Brain networks are fundamental in understanding how the brain operates. Effects on remote areas can be directly observed or identified after a period of stimulation, and each section of this review will discuss one method. EEG analyzed following TMS is called TMS-evoked potentials (TEPs). A conditioning TMS can influence the effect of a test TMS given over the motor cortex...
November 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28928648/a-single-session-of-rtms-enhances-small-worldness-in-writer-s-cramp-evidence-from-simultaneous-eeg-fmri-multi-modal-brain-graph
#9
Rose D Bharath, Rajanikant Panda, Venkateswara Reddy Reddam, M V Bhaskar, Suril Gohel, Sujas Bhardwaj, Arvind Prajapati, Pramod Kumar Pal
Background and Purpose: Repetitive transcranial magnetic stimulation (rTMS) induces widespread changes in brain connectivity. As the network topology differences induced by a single session of rTMS are less known we undertook this study to ascertain whether the network alterations had a small-world morphology using multi-modal graph theory analysis of simultaneous EEG-fMRI. Method: Simultaneous EEG-fMRI was acquired in duplicate before (R1) and after (R2) a single session of rTMS in 14 patients with Writer's Cramp (WC)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28927961/clinical-and-electrophysiological-outcomes-of-deep-tms-over-the-medial-prefrontal-and-anterior-cingulate-cortices-in-ocd-patients
#10
Lior Carmi, Uri Alyagon, Noam Barnea-Ygael, Joseph Zohar, Reuven Dar, Abraham Zangen
BACKGROUND: Obsessive Compulsive Disorder (OCD) is a chronic and disabling disorder with poor response to pharmacological treatments. Converging evidences suggest that OCD patients suffer from dysfunction of the cortico-striato-thalamo-cortical (CSTC) circuit, including in the medial prefrontal cortex (mPFC) and the anterior cingulate cortex (ACC). OBJECTIVE: To examine whether modulation of mPFC-ACC activity by deep transcranial magnetic stimulation (DTMS) affects OCD symptoms...
September 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28905370/neuromodulation-and-devices-in-trigeminal-neuralgia
#11
Kevin Weber
PREMISE: Trigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. PROBLEM: Therapies for trigeminal neuralgia and neuropathy have often been pharmacologic or surgical. Pharmacologic therapies are not effective in some cases and often cause side effects, some substantial...
September 14, 2017: Headache
https://www.readbyqxmd.com/read/28822321/neurostimulation-techniques-in-the-treatment-of-cocaine-dependence-a-review-of-the-literature
#12
REVIEW
Fady Rachid
OBJECTIVE: Cocaine use disorder is a very common condition that represents a substantial public health problem, and no effective pharmacological or psychological therapies have been identified to date. Urgent therapeutic alternatives are therefore needed such as neurostimulation techniques. The purpose of this review is to describe and discuss studies that have evaluated the safety and efficacy of these techniques for the treatment of cocaine dependence. METHODS: The electronic literature on repetitive transcranial magnetic stimulation, theta-burst stimulation, deep transcranial magnetic stimulation, transcranial direct current stimulation, magnetic seizure therapy, electroconvulsive therapy, cranial electro-stimulation, and deep brain stimulation in the treatment of cocaine addiction were reviewed...
January 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/28802935/depression-and-anxiety-in-parkinson-s-disease
#13
Anette Schrag, Raquel N Taddei
Depression and anxiety are some of the most common comorbidities arising in patients with Parkinson's disease. However, their timely recognition and diagnosis are often hindered by overlap with other somatic features and a low rate of self-report. There is a need for greater awareness and for better assessment and treatment options are highly required. Currently available scales can serve as tools to monitor change over time and the effect of interventional strategies. Development of new therapeutic strategies, including nonpharmacological approaches such as transcranial magnetic stimulation and deep brain stimulation, may provide alternatives to currently available treatment approaches...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28664353/adopting-reciprocity-theorem-in-deep-transcranial-magnetic-stimulation-problem-to-design-an-efficient-single-source-coil-array-based-on-nerve-cell-direction
#14
Ali Mohtadi Jafari, Ali Abdolali
Deep transcranial magnetic stimulation (dTMS) plays an important role in the treatment of many diseases. Previous designs rarely considered the direction of the induced electric field (E) with respect to nerve fibers. However, it can be observed from related formulae that the tangential component of E (E effective) has a more significant role in the stimulation of nerve cells. In this paper, a new approach is proposed for designing a single-source coil array (CA) by combining tractography and the reciprocity theorem (RT)...
June 29, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28663570/brain-stimulation-in-obesity
#15
REVIEW
C H Göbel, V M Tronnier, T F Münte
Obesity is taking up epidemic proportions worldwide with significant impacts on the health of both the affected individual and on society as a whole. Treatment approaches consist of behavioural and pharmacological approaches, however, these are often found to be ineffective. In severe obesity, bariatric surgery is frequently performed. Unfortunately, 40% of patients show substantial weight gain over the long term or display the associated metabolic syndrome, making the development of novel therapies necessary...
June 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28655149/neuromodulation-of-axon-terminals
#16
Darpan Chakraborty, Dennis Q Truong, Marom Bikson, Hanoch Kaphzan
Understanding which cellular compartments are influenced during neuromodulation underpins any rational effort to explain and optimize outcomes. Axon terminals have long been speculated to be sensitive to polarization, but experimentally informed models for CNS stimulation are lacking. We conducted simultaneous intracellular recording from the neuron soma and axon terminal (blebs) during extracellular stimulation with weak sustained (DC) uniform electric fields in mouse cortical slices. Use of weak direct current stimulation (DCS) allowed isolation and quantification of changes in axon terminal biophysics, relevant to both suprathreshold (e...
June 24, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28586349/comparison-of-the-induced-fields-using-different-coil-configurations-during-deep-transcranial-magnetic-stimulation
#17
Mai Lu, Shoogo Ueno
Stimulation of deeper brain structures by transcranial magnetic stimulation (TMS) plays a role in the study of reward and motivation mechanisms, which may be beneficial in the treatment of several neurological and psychiatric disorders. However, electric field distributions induced in the brain by deep transcranial magnetic stimulation (dTMS) are still unknown. In this paper, the double cone coil, H-coil and Halo-circular assembly (HCA) coil which have been proposed for dTMS have been numerically designed. The distributions of magnetic flux density, induced electric field in an anatomically based realistic head model by applying the dTMS coils were numerically calculated by the impedance method...
2017: PloS One
https://www.readbyqxmd.com/read/28570499/stable-remission-of-multiple-chemical-sensitivity-syndrome-and-major-depression-with-citalopram-and-1-month-deep-transcranial-magnetic-stimulation-a-case-report
#18
LETTER
Antonio Del Casale, Chiara Rapinesi, Georgios D Kotzalidis, Serena Sorice, Alessio Padovano, Giovanna Gentile, Gloria Angeletti, Stefano Ferracuti, Gabriele Sani, Maurizio Pompili, Maurizio Simmaco, Paolo Girardi
No abstract text is available yet for this article.
September 2017: Journal of ECT
https://www.readbyqxmd.com/read/28545010/factors-associated-with-response-after-deep-transcranial-magnetic-stimulation-in-a-real-world-clinical-setting-results-from-the-first-40-cases-of-treatment-resistant-depression
#19
K Feffer, K A B Lapidus, Y Braw, Y Bloch, S Kron, R Netzer, U Nitzan
BACKGROUND: Deep transcranial magnetic stimulation (dTMS) has been sanctioned by the United States Food and Drug Administration for treatment-resistant depression. In a retrospective cohort study, we evaluated response and effectiveness of dTMS in real-world practice, as an add-on treatment for resistant depression. METHODS: Forty adult outpatients suffering from depression, all taking psychiatric medications, underwent 20 dTMS treatments over a 4-6 week period...
April 11, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28525197/-treatment-resistant-depression-actuality-and-perspectives-in-2017
#20
REVIEW
N Lucas, P Hubain, G Loas, F Jurysta
Major depressive disorder (MDD) affects 3 to 17 % of adults. 15 to 30 % of patients with MDD suffer from treatment resistant depression (TRD). No international consensus defines TRD. The most common definition is " MDD that is not enough improved after two successive and different classes of antidepressant treatments in appropriate dose and duration ". The appropriate dose corresponds to maximal dose accepted by scientific reports and clinical recommendations, while the appropriate duration is around 6 weeks...
2017: Revue Médicale de Bruxelles
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