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https://www.readbyqxmd.com/read/27901460/anesthesia-case-of-the-month
#1
Elizabeth M Goudie-DeAngelis, Erin L Wendt-Hornickle, Daniel C Almeida, Lindsey A Murphy, Lynelle F Graham
No abstract text is available yet for this article.
December 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27899602/the-human-phenotype-ontology-in-2017
#2
Sebastian Köhler, Nicole A Vasilevsky, Mark Engelstad, Erin Foster, Julie McMurry, Ségolène Aymé, Gareth Baynam, Susan M Bello, Cornelius F Boerkoel, Kym M Boycott, Michael Brudno, Orion J Buske, Patrick F Chinnery, Valentina Cipriani, Laureen E Connell, Hugh J S Dawkins, Laura E DeMare, Andrew D Devereau, Bert B A de Vries, Helen V Firth, Kathleen Freson, Daniel Greene, Ada Hamosh, Ingo Helbig, Courtney Hum, Johanna A Jähn, Roger James, Roland Krause, Stanley J F Laulederkind, Hanns Lochmüller, Gholson J Lyon, Soichi Ogishima, Annie Olry, Willem H Ouwehand, Nikolas Pontikos, Ana Rath, Franz Schaefer, Richard H Scott, Michael Segal, Panagiotis I Sergouniotis, Richard Sever, Cynthia L Smith, Volker Straub, Rachel Thompson, Catherine Turner, Ernest Turro, Marijcke W M Veltman, Tom Vulliamy, Jing Yu, Julie von Ziegenweidt, Andreas Zankl, Stephan Züchner, Tomasz Zemojtel, Julius O B Jacobsen, Tudor Groza, Damian Smedley, Christopher J Mungall, Melissa Haendel, Peter N Robinson
Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.human-phenotype-ontology.org) project are the phenotype vocabulary, disease-phenotype annotations and the algorithms that operate on these. These components are being used for computational deep phenotyping and precision medicine as well as integration of clinical data into translational research...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898609/micrometastatic-dormancy-in-uveal-melanoma-a-comprehensive-review-of-the-evidence-mechanisms-and-implications-for-future-adjuvant-therapies
#3
Erin E Nichols, Ann Richmond, Anthony B Daniels
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27892921/an-essential-role-for-bacterial-nitric-oxide-synthase-in-staphylococcus-aureus-electron-transfer-and-colonization
#4
Traci L Kinkel, Smirla Ramos-Montañez, Jasmine M Pando, Daniel V Tadeo, Erin N Strom, Stephen J Libby, Ferric C Fang
Nitric oxide (NO(•)) is a ubiquitous molecular mediator in biology. Many signalling actions of NO(•) generated by mammalian NO(•) synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environmental bacteria also produce a NOS that is evolutionary related to the mammalian enzymes, but a bacterial haem-containing receptor for endogenous enzymatically generated NO(•) has not been identified previously. Here, we show that NOS of the human pathogen Staphylococcus aureus, in concert with an NO(•)-metabolizing flavohaemoprotein, regulates electron transfer by targeting haem-containing cytochrome oxidases under microaerobic conditions to maintain membrane bioenergetics...
November 28, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27882612/the-relationship-between-geometry-of-the-extensor-mechanism-of-the-knee-and-risk-of-anterior-cruciate-ligament-injury
#5
Josh C Carter, Daniel R Sturnick, Pamela M Vacek, Michael J DeSarno, Erin C Argentieri, James R Slauterbeck, Robert J Johnson, Bruce D Beynnon
The complex inter-segmental forces that are developed across an extended knee by body weight and contraction of the quadriceps muscle group transmits an anteriorly-directed force on the tibia that strain the anterior cruciate ligament (ACL). We hypothesized that a relationship exists between geometry of the knees extensor mechanism and the risk of sustaining a non-contact ACL injury. Geometry of the extensor mechanism was characterized using MRI scans of the knees of 88 subjects that suffered their first non-contact ACL injury and 88 matched control subjects with normal knees that were on the same team...
November 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27882518/residents-and-fellows-knowledge-and-attitudes-about-eating-disorders-at-an-academic-medical-center
#6
Kristen Anderson, Erin C Accurso, Kathryn R Kinasz, Daniel Le Grange
OBJECTIVE: This study examined physician residents' and fellows' knowledge of eating disorders and their attitudes toward patients with eating disorders. METHODS: Eighty physicians across disciplines completed a survey. The response rate for this survey across disciplines was 64.5 %. RESULTS: Participants demonstrated limited knowledge of eating disorders and reported minimal comfort levels treating patients with eating disorders. Psychiatry discipline (p = 0...
November 23, 2016: Academic Psychiatry
https://www.readbyqxmd.com/read/27880784/cdh1-missense-variant-c-1679c-g-p-t560r-completely-disrupts-normal-splicing-through-creation-of-a-novel-5-splice-site
#7
Zarina Yelskaya, Ruben Bacares, Erin Salo-Mullen, Joshua Somar, Deborah A Lehrich, Grace-Ann Fasaye, Daniel G Coit, Laura H Tang, Zsofia K Stadler, Liying Zhang
Disease-causing germline mutations in CDH1 cause Hereditary Diffuse Gastric Cancer (HDGC). For patients who meet the HDGC screening criteria, the identification and classification of the sequence variants found in CDH1 are critical for risk management of patients. In this report, we describe a germline CDH1 c.1679C>G (p.T560R) variant identified in a 50 year old man who was diagnosed with gastric cancer with a strong family history of gastric cancer (one living brother was diagnosed with gastric cancer at 63 and another brother died of gastric cancer at 45)...
2016: PloS One
https://www.readbyqxmd.com/read/27871626/photolysis-of-2-4-6-trinitrotoluene-in-seawater-and-estuary-water-impact-of-ph-temperature-salinity-and-dissolved-organic-matter
#8
Dianne J Luning Prak, James E T Breuer, Evelyn A Rios, Erin E Jedlicka, Daniel W O'Sullivan
The influence of salinity, pH, temperature, and dissolved organic matter on the photolysis rate of 2,4,6-trinitrotoluene (TNT) in marine, estuary, and laboratory-prepared waters was studied using a Suntest CPS+® solar simulator equipped with optical filters. TNT degradation rates were determined using HPLC analysis, and products were identified using LC/MS. Minimal or no TNT photolysis occurred under a 395-nm long pass filter, but under a 295-nm filter, first-order TNT degradation rate constants and apparent quantum yields increased with increasing salinity in both natural and artificial seawater...
November 18, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27868477/association-between-olfaction-and-higher-cortical-functions-in-alzheimer-s-disease-mild-cognitive-impairment-and-healthy-older-adults
#9
Amanda M Ward, Matthew Calamia, Erin Thiemann, Jamie Dunlap, Daniel Tranel
INTRODUCTION: Neural regions important for smell are proximal and closely connected to cortical areas that have been strongly implicated in higher order functions of value-based decision making and emotional memory. The integrity of these neural regions are affected in aging and neurodegenerative conditions. Two specific predictions follow from these neuroanatomical arrangements-namely, that olfaction would be associated with value-based decision making and with emotional memory. METHOD: To test these predictions, we measured these different capacities in participants with presumed varying degrees of integrity of the relevant brain structures: specifically, 13 patients with Alzheimer's disease, 8 patients with mild cognitive impairment, and 20 healthy older adults...
November 20, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27862127/the-impact-of-dsm-5-on-eating-disorder-diagnoses
#10
Megen Vo, Erin C Accurso, Andrea B Goldschmidt, Daniel Le Grange
OBJECTIVE: Eating disorder diagnostic criteria were revised from the fourth to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV and -5, respectively). This study examines the impact of these revisions on rates of eating disorder diagnoses in treatment-seeking youth. METHOD: Participants were 651 youth, ages 7-18 years, presenting to an outpatient eating disorders program who met criteria for a DSM-IV eating disorder diagnosis on intake...
November 12, 2016: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27861236/healthcare-access-and-prep-continuation-in-san-francisco-and-miami-following-the-u-s-prep-demo-project
#11
Susanne Doblecki-Lewis, Albert Liu, Daniel Feaster, Stephanie E Cohen, Gabriel Cardenas, Oliver Bacon, Erin Andrew, Michael A Kolber
Pre-exposure prophylaxis (PrEP) for prevention of HIV infection has demonstrated efficacy in randomized controlled trials as well as in demonstration projects. For PrEP implementation to result in significant reductions in HIV incidence for men who have sex with men (MSM) in the United States, sufficient access to PrEP care and continued engagement outside of demonstration projects is required. We report the results of a follow-up survey of 173 former participants from the Miami and San Francisco sites of the U...
November 14, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27856350/achilles-is-a-circadian-clock-controlled-gene-that-regulates-immune-function-in-drosophila
#12
Jiajia Li, Erin E Terry, Edith Fejer, Diana Gamba, Natalie Hartmann, Joseph Logsdon, Daniel Michalski, Lisa E Rois, Maria J Scuderi, Michael Kunst, Michael E Hughes
The circadian clock is a transcriptional/translational feedback loop that drives the rhythmic expression of downstream mRNAs. Termed "clock-controlled genes," these molecular outputs of the circadian clock orchestrate cellular, metabolic, and behavioral rhythms. As part of our on-going work to characterize key upstream regulators of circadian mRNA expression, we have identified a novel clock-controlled gene in Drosophila melanogaster, Achilles (Achl), which is rhythmic at the mRNA level in the brain and which represses expression of anti-microbial peptides in the immune system...
November 14, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27851626/1992-methylene-blue-in-refractory-septic-shock-losing-our-way-for-the-sake-of-a-map
#13
Cyril Varghese, Erin Demartino, Egan Ashley, Jaclyn Jacobi, Daniels Lisa, Korosh Sharain, Jeremy Clain
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849869/227-individualized-diuretic-dosing-in-the-emergency-department-for-acute-decompensated-heart-failure
#14
James Catlin, Erin Nagle, Christopher Adams, Daniel Louie, Machelle Wilson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27842986/investigation-of-a-guillain-barr%C3%A3-syndrome-cluster-in-the-republic-of-fiji
#15
Daniel M Pastula, Aalisha Sahu Khan, Tyler M Sharp, Viema L Biaukula, Taina K Naivalu, Eric Rafai, Ermias Belay, J Erin Staples, Marc Fischer, Olga I Kosoy, Janeen J Laven, Elizabeth J Bennett, Adam W J Jenney, Ravi Narayan Naidu, Robert S Lanciotti, Renee L Galloway, Eric J Nilles, James J Sejvar, Mike Kama
BACKGROUND: In 2014, we investigated a cluster of Guillain-Barre syndrome (GBS) in Fiji that occurred during a dengue epidemic. We designed a case-control study to determine the etiology. METHODS: Cases were patients meeting Brighton Collaboration criteria for GBS with onset from February 2014 to May 2014. Controls were persons without symptoms of GBS who were matched by age group and location. We collected information on demographics and potential exposures. Serum samples were tested for evidence of recent arboviral or Leptospira spp...
September 1, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27836049/mapping-u-s-cattle-shipment-networks-spatial-and-temporal-patterns-of-trade-communities-from-2009-to-2011
#16
Erin E Gorsich, Angela D Luis, Michael G Buhnerkempe, Daniel A Grear, Katie Portacci, Ryan S Miller, Colleen T Webb
The application of network analysis to cattle shipments broadens our understanding of shipment patterns beyond pairwise interactions to the network as a whole. Such a quantitative description of cattle shipments in the U.S. can identify trade communities, describe temporal shipment patterns, and inform the design of disease surveillance and control strategies. Here, we analyze a longitudinal dataset of beef and dairy cattle shipments from 2009 to 2011 in the United States to characterize communities within the broader cattle shipment network, which are groups of counties that ship mostly to each other...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27832824/genome-of-the-asian-longhorned-beetle-anoplophora-glabripennis-a-globally-significant-invasive-species-reveals-key-functional-and-evolutionary-innovations-at-the-beetle-plant-interface
#17
Duane D McKenna, Erin D Scully, Yannick Pauchet, Kelli Hoover, Roy Kirsch, Scott M Geib, Robert F Mitchell, Robert M Waterhouse, Seung-Joon Ahn, Deanna Arsala, Joshua B Benoit, Heath Blackmon, Tiffany Bledsoe, Julia H Bowsher, André Busch, Bernarda Calla, Hsu Chao, Anna K Childers, Christopher Childers, Dave J Clarke, Lorna Cohen, Jeffery P Demuth, Huyen Dinh, HarshaVardhan Doddapaneni, Amanda Dolan, Jian J Duan, Shannon Dugan, Markus Friedrich, Karl M Glastad, Michael A D Goodisman, Stephanie Haddad, Yi Han, Daniel S T Hughes, Panagiotis Ioannidis, J Spencer Johnston, Jeffery W Jones, Leslie A Kuhn, David R Lance, Chien-Yueh Lee, Sandra L Lee, Han Lin, Jeremy A Lynch, Armin P Moczek, Shwetha C Murali, Donna M Muzny, David R Nelson, Subba R Palli, Kristen A Panfilio, Dan Pers, Monica F Poelchau, Honghu Quan, Jiaxin Qu, Ann M Ray, Joseph P Rinehart, Hugh M Robertson, Richard Roehrdanz, Andrew J Rosendale, Seunggwan Shin, Christian Silva, Alex S Torson, Iris M Vargas Jentzsch, John H Werren, Kim C Worley, George Yocum, Evgeny M Zdobnov, Richard A Gibbs, Stephen Richards
BACKGROUND: Relatively little is known about the genomic basis and evolution of wood-feeding in beetles. We undertook genome sequencing and annotation, gene expression assays, studies of plant cell wall degrading enzymes, and other functional and comparative studies of the Asian longhorned beetle, Anoplophora glabripennis, a globally significant invasive species capable of inflicting severe feeding damage on many important tree species. Complementary studies of genes encoding enzymes involved in digestion of woody plant tissues or detoxification of plant allelochemicals were undertaken with the genomes of 14 additional insects, including the newly sequenced emerald ash borer and bull-headed dung beetle...
November 11, 2016: Genome Biology
https://www.readbyqxmd.com/read/27795353/purine-biosynthesis-metabolically-constrains-intracellular-survival-of-uropathogenic-e-coli
#18
Carrie L Shaffer, Ellisa W Zhang, Anne G Dudley, Beverly R E A Dixon, Kirsten R Guckes, Erin J Breland, Kyle A Floyd, Daniel P Casella, Holly M Scott Algood, Douglass B Clayton, Maria Hadjifrangiskou
The ability to de novo synthesize purines has been associated with the intracellular survival of multiple bacterial pathogens. Uropathogenic Escherichia coli (UPEC), the predominant cause of urinary tract infections, undergoes a transient intracellular lifestyle during which bacteria clonally expand into multicellular bacterial communities within the cytoplasm of bladder epithelial cells. Here, we characterized the contribution of the conserved de novo purine biosynthesis-associated locus cvpA-purF to UPEC pathogenesis...
October 17, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27792790/phactr1-is-a-genetic-susceptibility-locus-for-fibromuscular-dysplasia-supporting-its-complex-genetic-pattern-of-inheritance
#19
Soto Romuald Kiando, Nathan R Tucker, Luis-Jaime Castro-Vega, Alexander Katz, Valentina D'Escamard, Cyrielle Tréard, Daniel Fraher, Juliette Albuisson, Daniella Kadian-Dodov, Zi Ye, Erin Austin, Min-Lee Yang, Kristina Hunker, Cristina Barlassina, Daniele Cusi, Pilar Galan, Jean-Philippe Empana, Xavier Jouven, Anne-Paule Gimenez-Roqueplo, Patrick Bruneval, Esther Soo Hyun Kim, Jeffrey W Olin, Heather L Gornik, Michel Azizi, Pierre-François Plouin, Patrick T Ellinor, Iftikhar J Kullo, David J Milan, Santhi K Ganesh, Pierre Boutouyrie, Jason C Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD is often an underdiagnosed cause of hypertension and stroke, has higher prevalence in females (~80%) but its pathophysiology is unclear. We analyzed ~26K common variants (MAF>0.05) generated by exome-chip arrays in 249 FMD patients and 689 controls. We replicated 13 loci (P<10-4) in 402 cases and 2,537 controls and confirmed an association between FMD and a variant in the phosphatase and actin regulator 1 gene (PHACTR1)...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27775997/withholding-versus-continuing-angiotensin-converting-enzyme-inhibitors-or-angiotensin-ii-receptor-blockers-before-noncardiac-surgery-an-analysis-of-the-vascular-events-in-noncardiac-surgery-patients-cohort-evaluation-prospective-cohort
#20
Pavel S Roshanov, Bram Rochwerg, Ameen Patel, Omid Salehian, Emmanuelle Duceppe, Emilie P Belley-Côté, Gordon H Guyatt, Daniel I Sessler, Yannick Le Manach, Flavia K Borges, Vikas Tandon, Andrew Worster, Alexandra Thompson, Mithin Koshy, Breagh Devereaux, Frederick A Spencer, Robert D Sanders, Erin N Sloan, Erin E Morley, James Paul, Karen E Raymer, Zubin Punthakee, P J Devereaux
BACKGROUND: The effect on cardiovascular outcomes of withholding angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac surgery is unknown. METHODS: In this international prospective cohort study, the authors analyzed data from 14,687 patients (including 4,802 angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker users) at least 45 yr old who had in-patient noncardiac surgery from 2007 to 2011...
October 24, 2016: Anesthesiology
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