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Erin daniels

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https://www.readbyqxmd.com/read/29041009/fcgr2a-and-fcgr3a-genotypes-correlate-with-farletuzumab-response-in-patients-with-first-relapsed-ovarian-cancer-exhibiting-low-ca125
#1
Wenquan Wang, Elizabeth B Somers, Erin N Ross, J Bradford Kline, Daniel J O'Shannessy, Charles Schweizer, Susan Weil, Luigi Grasso, Nicholas C Nicolaides
Farletuzumab is a humanized monoclonal antibody that binds to folate receptor alpha and elicits an anti-tumor response via immune effector activity. Recent studies from a global phase 3 trial in ovarian cancer patients treated with carboplatin/taxane plus farletuzumab found that the tumor-produced CA125 protein can suppress farletuzumab function via perturbing its engagement to the activating Fc-γ receptors CD32a (FCGR2A) and CD16a (FCGR3A). Previous reports have indicated that naturally occurring polymorphisms in both of these receptors may play a role in their ability to engage therapeutic antibodies and elicit an optimal immune response via antibody-dependent cellular cytotoxicity (ADCC)...
October 18, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29030677/safe-surgery-for-all-early-lessons-from-implementing-a-national-government-driven-surgical-plan-in-ethiopia
#2
Daniel Burssa, Atlibachew Teshome, Katherine Iverson, Olivia Ahearn, Tigistu Ashengo, David Barash, Erin Barringer, Isabelle Citron, Kaya Garringer, Victoria McKitrick, John Meara, Abraham Mengistu, Swagoto Mukhopadhyay, Cheri Reynolds, Mark Shrime, Asha Varghese, Samson Esseye, Abebe Bekele
Recognizing the unmet need for surgical care in Ethiopia, the Federal Ministry of Health (FMOH) has pioneered innovative methodologies for surgical system development with Saving Lives through Safe Surgery (SaLTS). SaLTS is a national flagship initiative designed to improve access to safe, essential and emergency surgical and anaesthesia care across all levels of the healthcare system. Sustained commitment from the FMOH and their recruitment of implementing partners has led to notable accomplishments across the breadth of the surgical system, including but not limited to: (1) Leadership, management and governance-a nationally scaled surgical leadership and mentorship programme, (2) Infrastructure-operating room construction and oxygen delivery plan, (3) Supplies and logistics-a national essential surgical procedure and equipment list, (4) Human resource development-a Surgical Workforce Expansion Plan and Anaesthesia National Roadmap, (5) Advocacy and partnership-strong FMOH partnership with international organizations, including GE Foundation's SafeSurgery2020 initiative, (6) Innovation-facility-driven identification of problems and solutions, (7) Quality of surgical and anaesthesia care service delivery-a national peri-operative guideline and WHO Surgical Safety Checklist implementation, and (8) Monitoring and evaluation-a comprehensive plan for short-term and long-term assessment of surgical quality and capacity...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29028449/geometric-characteristics-of-the-knee-are-associated-with-a-noncontact-acl-injury-to-the-contralateral-knee-after-unilateral-acl-injury-in-young-female-athletes
#3
James G Levins, Erin C Argentieri, Daniel R Sturnick, Mack Gardner-Morse, Pamela M Vacek, Timothy W Tourville, Robert J Johnson, James R Slauterbeck, Bruce D Beynnon
BACKGROUND: Contralateral anterior cruciate ligament (CACL) injury after recovery from a first-time ACL rupture occurs at a high rate in young females; however, little is known about the risk factors associated with bilateral ACL trauma. HYPOTHESIS: The geometric characteristics of the contralateral knee at the time of the initial ACL injury are associated with risk of suffering a CACL injury in these female athletes. STUDY DESIGN: Case-control study; Level of evidence, 3...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29025984/synthesis-and-biological-evaluation-of-a-novel-18-f-labeled-adnectin-as-a-pet-radioligand-for-imaging-pd-l1-expression
#4
David J Donnelly, Ralph Adam Smith, Paul Morin, Dasa Lipovsek, Jochem Gokemeijer, Daniel Cohen, Virginie Lafont, Tritin Tran, Erin Lee Cole, Martin Wright, Joonyoung Kim, Adrienne Pena, Daniel Kukral, Douglas D Dischino, Patrick Chow, Jinping Gan, Olufemi Adelakun, Xi-Tao Wang, Kai Cao, David Lueng, Samuel Bonacorsi, Wendy Hayes
The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint pathway cancer cells exploit to evade the immune system. A same-day PET imaging agent for measuring PD-L1 status in primary and metastatic lesions could be important for optimizing drug therapy. Herein, we have evaluated the tumor targeting of an anti-PD-L1 Adnectin after (18)F-fluorine labeling. Methods: An anti-PD-L1 Adnectin was labeled with (18)F in two steps. This synthesis featured fluorination of a novel prosthetic group, followed by a copper-free click conjugation to a modified Adnectin to generate (18)F-BMS-986192...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29020178/uptake-of-antibiotic-stewardship-programs-in-u-s-acute-care-hospitals-findings-from-the-2015-national-healthcare-safety-network-annual-hospital-survey
#5
Erin N O'Leary, Katharina L van Santen, Amy K Webb, Daniel A Pollock, Jonathan R Edwards, Arjun Srinivasan
To assess uptake of the Centers for Disease Control and Prevention's Core Elements of Hospital Antibiotic Stewardship Programs, we analyzed stewardship practices as reported in the 2015 National Healthcare Safety Network's Annual Hospital Survey. Hospital uptake of all 7 core elements increased from 40.9% in 2014 to 48.1% in 2015.
July 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28987119/investigation-of-the-two-and-three-fragment-photodissociation-of-the-tert-butyl-peroxy-radical-at-248-nm
#6
Bethan Nichols, Erin N Sullivan, Mikhail Ryazanov, Cynthia M Hong, Daniel M Neumark
The photodissociation dynamics of the tert-butyl peroxy (t-BuOO) radical are studied by fast-radical-beam coincidence translational spectroscopy. The neutral t-BuOO radical is formed by photodetachment of the corresponding t-BuOO(-) anion at 700 nm (1.77 eV), followed by dissociation at 248 nm (5.00 eV). Photofragment mass and translational energy distributions are obtained. The major channel is found to be three-body fragmentation to form O, CH3, and acetone (83%), with minor two-body fragmentation channels leading to the formation of O2 + tert-butyl radical (10%) and HO2 + isobutene (7%)...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28984377/age-and-sex-related-effects-in-children-with-mild-traumatic-brain-injury-on-diffusion-magnetic-resonance-imaging-properties-a-comparison-of-voxelwise-and-tractography-methods
#7
Naomi J Goodrich-Hunsaker, Tracy J Abildskov, Garrett Black, Erin D Bigler, Daniel M Cohen, Leslie K Mihalov, Barbara A Bangert, H Gerry Taylor, Keith O Yeates
Although there are several techniques to analyze diffusion-weighted imaging, any technique must be sufficiently sensitive to detect clinical abnormalities. This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology is likely to be subtle. mTBI represents a major public health concern, especially for youth under 15 years of age. However, the developmental period from birth to 18 years is also a time of tremendous brain changes. Therefore, it is important to establish the degree of age- and sex-related differences...
October 6, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28981486/update-influenza-activity-united-states-and-worldwide-may-21-september-23-2017
#8
Lenee Blanton, David E Wentworth, Noreen Alabi, Eduardo Azziz-Baumgartner, John Barnes, Lynnette Brammer, Erin Burns, C Todd Davis, Vivien G Dugan, Alicia M Fry, Rebecca Garten, Lisa A Grohskopf, Larisa Gubareva, Krista Kniss, Stephen Lindstrom, Desiree Mustaquim, Sonja J Olsen, Katherine Roguski, Calli Taylor, Susan Trock, Xiyan Xu, Jacqueline Katz, Daniel Jernigan
During May 21-September 23, 2017,* the United States experienced low-level seasonal influenza virus activity; however, beginning in early September, CDC received reports of a small number of localized influenza outbreaks caused by influenza A(H3N2) viruses. In addition to influenza A(H3N2) viruses, influenza A(H1N1)pdm09 and influenza B viruses were detected during May-September worldwide and in the United States. Influenza B viruses predominated in the United States from late May through late June, and influenza A viruses predominated beginning in early July...
October 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28978444/coupling-x-ray-reflectivity-and-in-silico-binding-to-yield-dynamics-of-membrane-recognition-by-tim1
#9
Gregory T Tietjen, Javier L Baylon, Daniel Kerr, Zhiliang Gong, J Michael Henderson, Charles T R Heffern, Mati Meron, Binhua Lin, Mark L Schlossman, Erin J Adams, Emad Tajkhorshid, Ka Yee C Lee
The dynamic nature of lipid membranes presents significant challenges with respect to understanding the molecular basis of protein/membrane interactions. Consequently, there is relatively little known about the structural mechanisms by which membrane-binding proteins might distinguish subtle variations in lipid membrane composition and/or structure. We have previously developed a multidisciplinary approach that combines molecular dynamics simulation with interfacial x-ray scattering experiments to produce an atomistic model for phosphatidylserine recognition by the immune receptor Tim4...
October 3, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28976747/purification-and-characterization-of-rhopde-a-retinylidene-phosphodiesterase-fusion-protein-and-potential-optogenetic-tool-from-the-choanoflagellate-salpingoeca-rosetta
#10
Lindsey B Lamarche, Ramasamy P Kumar, Melissa M Trieu, Erin L Devine, Luke E Cohen-Abeles, Douglas L Theobald, Daniel D Oprian
RhoPDE is a type I rhodopsin/phosphodiesterase gene fusion product from the choanoflagellate Salpingoeca rosetta. The gene was discovered around the time that a similar type I rhodopsin/guanylyl cyclase fusion protein, RhoGC, was shown to control phototaxis of an aquatic fungus through a cGMP signaling pathway. RhoPDE has potential as an optogenetic tool catalyzing the hydrolysis of cyclic nucleotides. Here we provide an expression and purification system for RhoPDE, as well as a crystal structure of the C-terminal phosphodiesterase catalytic domain...
October 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28967177/mutualistic-interaction-between-dichloromethane-and-chloromethane-degrading-bacteria-in-an-anaerobic-mixed-culture
#11
Gao Chen, Sara Kleindienst, Daniel R Griffiths, E Erin Mack, Edward S Seger, Frank E Löffler
The microbial mixed culture RM grows with dichloromethane (DCM) as the sole energy source generating acetate, methane, chloride and biomass as products. Chloromethane (CM) was not an intermediate during DCM utilization consistent with the observation that CM could not replace DCM as a growth substrate. Interestingly, cultures that received DCM and CM together degraded both compounds concomitantly. Transient hydrogen (H2 ) formation reaching a maximum concentration of 205 ± 13 ppmv was observed in cultures growing with DCM, and the addition of exogenous H2 at concentrations exceeding 3000 ppmv impeded DCM degradation...
October 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28957664/hdac5-and-its-target-gene-npas4-function-in-the-nucleus-accumbens-to-regulate-cocaine-conditioned-behaviors
#12
Makoto Taniguchi, Maria B Carreira, Yonatan A Cooper, Ana-Clara Bobadilla, Jasper A Heinsbroek, Nobuya Koike, Erin B Larson, Evan A Balmuth, Brandon W Hughes, Rachel D Penrod, Jaswinder Kumar, Laura N Smith, Daniel Guzman, Joseph S Takahashi, Tae-Kyung Kim, Peter W Kalivas, David W Self, Yingxi Lin, Christopher W Cowan
Individuals suffering from substance-use disorders develop strong associations between the drug's rewarding effects and environmental cues, creating powerful, enduring triggers for relapse. We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression...
September 27, 2017: Neuron
https://www.readbyqxmd.com/read/28957412/cohort-profile-the-canadian-hiv-women-s-sexual-and-reproductive-health-cohort-study-chiwos
#13
Mona Loutfy, Alexandra de Pokomandy, V Logan Kennedy, Allison Carter, Nadia O'Brien, Karène Proulx-Boucher, Erin Ding, Johanna Lewis, Valerie Nicholson, Kerrigan Beaver, Saara Greene, Wangari Tharao, Anita Benoit, Danièle Dubuc, Jamie Thomas-Pavanel, Paul Sereda, Shahab Jabbari, Jayson H Shurgold, Guillaume Colley, Robert S Hogg, Angela Kaida
Globally, women are at increased vulnerability to HIV due to biological, social, structural, and political reasons. Women living with HIV also experience unique issues related to their medical and social healthcare, which makes a clinical care model specific to their needs worthy of exploration. Furthermore, there is a dearth of research specific to women living with HIV. Research for this population has often been narrowly focused on pregnancy-related issues without considering their complex structural inequalities, social roles, and healthcare and biological needs...
2017: PloS One
https://www.readbyqxmd.com/read/28951262/prolapse-recurrence-following-sacrocolpopexy-versus-uterosacral-ligament-suspension-a-comparison-statified-by-popq-stage
#14
Erin Seifert Lavelle, Lauren Giugale, Daniel G Winger, Li Wang, Charelle M Carter-Brooks, Jonathan P Shepherd
BACKGROUND: Insufficient evidence evaluates which pelvic organ prolapse surgery is best suited to an individual woman based on the stage of her prolapse. OBJECTIVE: To compare prolapse recurrence rates following sacrocolpopexy and uterosacral ligament suspension after stratifying by preoperative POPQ stage. STUDY DESIGN: We compared all women who underwent minimally invasive sacrocolpopexy (SCP) or vaginal or minimally invasive uterosacral ligament suspension (USLS) from 2009-2015 at a large academic center...
September 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28947627/point-counterpoint
#15
Darragh Flannery, Erin J Howden, André La Gerche, Richard L Hughson, Anthony S Leicht, Daniel A Boullosa, Arto J Hautala, Li Zuo, Feng He
No abstract text is available yet for this article.
September 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28942967/de-novo-mutations-in-ppp3ca-cause-severe-neurodevelopmental-disease-with-seizures
#16
Candace T Myers, Nicholas Stong, Emily I Mountier, Katherine L Helbig, Saskia Freytag, Joseph E Sullivan, Bruria Ben Zeev, Andreea Nissenkorn, Michal Tzadok, Gali Heimer, Deepali N Shinde, Arezoo Rezazadeh, Brigid M Regan, Karen L Oliver, Michelle E Ernst, Natalie C Lippa, Maureen S Mulhern, Zhong Ren, Annapurna Poduri, Danielle M Andrade, Lynne M Bird, Melanie Bahlo, Samuel F Berkovic, Daniel H Lowenstein, Ingrid E Scheffer, Lynette G Sadleir, David B Goldstein, Heather C Mefford, Erin L Heinzen
Exome sequencing has readily enabled the discovery of the genetic mutations responsible for a wide range of diseases. This success has been particularly remarkable in the severe epilepsies and other neurodevelopmental diseases for which rare, often de novo, mutations play a significant role in disease risk. Despite significant progress, the high genetic heterogeneity of these disorders often requires large sample sizes to identify a critical mass of individuals with disease-causing mutations in a single gene...
October 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28935696/a-genome-wide-association-study-of-lch-identifies-a-variant-in-smad6-associated-with-susceptibility
#17
Erin C Peckham-Gregory, Rikhia Chakraborty, Michael E Scheurer, John W Belmont, Harshal Abhyankar, Amel G Sengal, Brooks P Scull, Olive Eckstein, Daniel J Zinn, Louisa Mayer, Albert Shih, Miriam Merad, D Williams Parsons, Kenneth L McClain, Philip J Lupo, Carl E Allen
No abstract text is available yet for this article.
September 21, 2017: Blood
https://www.readbyqxmd.com/read/28934093/combined-prenatal-pesticide-exposure-and-folic-acid-intake-in-relation-to-autism-spectrum-disorder
#18
Rebecca J Schmidt, Vladimir Kogan, Janie F Shelton, Lora Delwiche, Robin L Hansen, Sally Ozonoff, Claudia C Ma, Erin C McCanlies, Deborah H Bennett, Irva Hertz-Picciotto, Daniel J Tancredi, Heather E Volk
BACKGROUND: Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals. OBJECTIVE: We examined combined exposures to maternal FA and pesticides in relation to autism spectrum disorder (ASD). METHODS: Participants were California children born from 2000-2007 who were enrolled in the Childhood Autism Risks from Genetics and the Environment (CHARGE) case-control study at age 2-5 y, were clinically confirmed to have ASD (n=296) or typical development (n=220), and had information on maternal supplemental FA and pesticide exposures...
September 8, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28930104/liver-transplantation-in-the-obese-cirrhotic-patient
#19
REVIEW
Erin K Spengler, Jacqueline G O'Leary, Helen S Te, Shari Rogal, Anjana A Pillai, Abdullah Al-Osaimi, Archita Desai, James N Fleming, Daniel Ganger, Anil Seetharam, Georgios Tsoulfas, Martin Montenovo, Jennifer C Lai
Despite the rapidly increasing prevalence of obesity in the transplant population, the optimal management of obese liver transplant candidates remains undefined. Setting strict body mass index cutoffs for transplant candidacy remains controversial, with limited data to guide this practice. Body mass index is an imperfect measure of surgical risk in this population, partly due to volume overload and variable visceral adiposity. Weight loss before transplantation may be beneficial, but it remains important to avoid protein calorie malnutrition and sarcopenia...
October 2017: Transplantation
https://www.readbyqxmd.com/read/28928129/new-advances-and-challenges-of-targeting-cancer-stem-cells
#20
Nurmaa K Dashzeveg, Rokana Taftaf, Erika K Ramos, Luke Torre-Healy, Anastasia Chumakova, Daniel J Silver, Tyler J Alban, Maksim Sinyuk, Praveena S Thiagarajan, Awad M Jarrar, Soumya M Turaga, Caner Saygin, Erin Mulkearns-Hubert, Masahiro Hitomi, Jeremy N Rich, Stanton L Gerson, Justin D Lathia, Huiping Liu
The second International Cancer Stem Cell Conference in Cleveland, Ohio, on September 20-23, 2016, convened 330 attendees from academic, industrial, and clinical organizations. It featured a debate on the concepts and challenges of the cancer stem cells (CSC) as well as CSC-centered scientific sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression, metastasis, therapeutic resistance, and emerging novel concepts. The conference hosted 35 renowned speakers, 100 posters, 20 short talks, and a preconference workshop...
September 19, 2017: Cancer Research
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