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https://www.readbyqxmd.com/read/28434085/exploring-the-oral-microflora-of-preschool-children
#1
Wen Ren, Qun Zhang, Xuenan Liu, Shuguo Zheng, Lili Ma, Feng Chen, Tao Xu, Baohua Xu
The oral cavity is one of the most important and complicated habitats in our body and supports diverse microbial communities. In this study, we aimed to determine the bacterial diversity and composition of various oral micro-niches. Samples were collected from supragingival plaque, saliva, and tongue coating from 10 preschool children (30 samples total). 16S rRNA gene pyrosequencing dataset generated 314,639 clean reads with an average of 10,488 ± 2,787 reads per sample. The phyla Firmicutes, Proteobacteria, Actinobacteria, Bacteroidetes, and Fusobacteria were predominant, accounting for more than 90% of the total sequences...
April 22, 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28425162/a-small-lick-will-sink-a-great-ship-fulminant-septicaemia-after-dog-saliva-wound-treatment-in-an-asplenic-patient
#2
Evi M Morandi, Reinhard Pauzenberger, Christoph Tasch, Ulrich M Rieger, Gerhard Pierer, Gabriel Djedovic
Capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. An infection can cause severe sepsis with acral necrosis and is potentially fatal. Here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. He went into septic shock with disseminated intravascular coagulation and subsequently lost both lower legs, his nose and all the fingers on both hands.
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28404012/a-non-endoscopic-device-to-sample-the-oesophageal-microbiota-a-case-control-study
#3
Daffolyn R Fels Elliott, Alan W Walker, Maria O'Donovan, Julian Parkhill, Rebecca C Fitzgerald
BACKGROUND: The strongest risk factor for oesophageal adenocarcinoma is reflux disease, and the rising incidence of this coincides with the eradication of Helicobacter pylori, both of which might alter the oesophageal microbiota. We aimed to profile the microbiota at different stages of Barrett's carcinogenesis and investigate the Cytosponge as a minimally invasive tool for sampling the oesophageal microbiota. METHODS: In this case-control study, 16S rRNA gene amplicon sequencing was done on 210 oesophageal samples from 86 patients representing the Barrett's oesophagus progression sequence (normal squamous controls [n=20], non-dysplastic [n=24] and dysplastic Barrett's oesophagus [n=23], and oesophageal adenocarcinoma [n=19]), relevant negative controls, and replicates on the Illumina MiSeq platform...
January 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403363/microbiological-lipid-and-immunological-profiles-in-children-with-gingivitis-and-type-1-diabetes-mellitus
#4
Cristiane Duque, Mariana Ferreira Dib João, Gabriela Alessandra da Cruz Galhardo Camargo, Gláucia Schuindt Teixeira, Thamiris Santana Machado, Rebeca de Souza Azevedo, Flávia Sammartino Mariano, Natália Helena Colombo, Natália Leal Vizoto, Renata de Oliveira Mattos-Graner
Objective: The aim of this study was to compare the prevalence of periodontal pathogens, systemic inflammatory mediators and lipid profiles in type 1 diabetes children (DM) with those observed in children without diabetes (NDM), both with gingivitis. Material and methods: Twenty-four DM children and twenty-seven NDM controls were evaluated. The periodontal status, glycemic and lipid profiles were determined for both groups. Subgingival samples of periodontal sites were collected to determine the prevalence of periodontal microorganisms by PCR...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28381687/bacteremia-due-to-capnocytophaga-species-during-chemotherapy-induced-neutropenia-in-patients-with-hematological-malignancies
#5
Koichi Murakami, Takehiko Mori, Jun Kato, Takayuki Shimizu, Sumiko Kohashi, Masatoshi Sakurai, Kayoko Sugita, Naoki Hasegawa, Mitsuru Murata, Shinichiro Okamoto
The number of reported cases of infections due to Capnocytophaga species (spp.) is limited. We herein describe four cases developing bacteremia due to Capnocytophaga spp. during neutropenia after chemotherapy for hematological malignancies. At the onset of bacteremia, 3 of the 4 patients had oral mucositis, and 2 were co-infected with other bacteria. Two patients developed bacteremia while receiving fluoroquinolone as prophylaxis against bacterial infection. Bacteremia resolved with administration of antimicrobial agents in all patients and no recurrences were observed thereafter...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28381610/-identification-of-virulent-capnocytophaga-canimorsus-isolates-by-capsular-typing
#6
Estelle Hess, Francesco Renzi, Dunia Koudad, Mélanie Dol, Guy R Cornelis
Capnocytophaga canimorsus is a dog oral commensal that causes rare but severe infections in humans. C. canimorsus was recently shown to be endowed with a capsular polysaccharide implicated in the resistance to the innate immune system of the host. Here we developed the first C. canimorsus capsular serotyping scheme. We describe nine different serovars (A to I), which allowed to type 25/25 isolates from human infections but only 18/52 isolates from dog mouths, indicating that the repertoire of capsules in the species is vast...
April 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28180088/human-case-of-bacteremia-caused-by-streptococcus-canis-sequence-type-9-harboring-the-scm-gene
#7
Daisuke Taniyama, Yoshihiko Abe, Tetsuya Sakai, Takahide Kikuchi, Takashi Takahashi
Streptococcus canis (Sc) is a zoonotic pathogen that is transferred mainly from companion animals to humans. One of the major virulence factors in Sc is the M-like protein encoded by the scm gene, which is involved in anti-phagocytic activities, as well as the recruitment of plasminogen to the bacterial surface in cooperation with enolase, and the consequent enhancement of bacterial transmigration and survival. This is the first reported human case of uncomplicated bacteremia following a dog bite, caused by Streptococcus canis harboring the scm gene...
2017: IDCases
https://www.readbyqxmd.com/read/28134123/fatal-infection-caused-by-capnocytophaga-canimorsus
#8
Hélène Taquin, Christophe Roussel, Laurent Roudière, Alain Besancon, Thomas Hubiche, Michel Kaidomar, Sophie Edouard, Pascal Del Giudice
No abstract text is available yet for this article.
February 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28029716/inactivation-of-human-coagulation-factor-x-by-a-protease-of-the-pathogen-capnocytophaga-canimorsus
#9
K Hack, F Renzi, E Hess, F Lauber, J Douxfils, J M Dogné, G R Cornelis
Essentials Capnocytophaga canimorsus causes severe dog bite related blood stream infections. We investigated if C. canimorsus contributes to bleeding abnormalities during infection. The C. canimorsus protease CcDPP7 causes factor X dysfunction by N-terminal cleavage. CcDPP7 inhibits coagulation in vivo, which could promote immune evasion and trigger hemorrhage. SUMMARY: Background Capnocytophaga canimorsus is a Gram-negative bacterium that is present in the oral flora of dogs and causes fulminant sepsis in humans who have been bitten, licked, or scratched...
December 28, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27974829/evidence-for-a-los-and-a-capsular-polysaccharide-in-capnocytophaga-canimorsus
#10
Francesco Renzi, Simon J Ittig, Irina Sadovskaya, Estelle Hess, Frederic Lauber, Melanie Dol, Hwain Shin, Manuela Mally, Chantal Fiechter, Ursula Sauder, Mohamed Chami, Guy R Cornelis
Capnocytophaga canimorsus is a dog's and cat's oral commensal which can cause fatal human infections upon bites or scratches. Infections mainly start with flu-like symptoms but can rapidly evolve in fatal septicaemia with a mortality as high as 40%. Here we present the discovery of a polysaccharide capsule (CPS) at the surface of C. canimorsus 5 (Cc5), a strain isolated from a fulminant septicaemia. We provide genetic and chemical data showing that this capsule is related to the lipooligosaccharide (LOS) and probably composed of the same polysaccharide units...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909820/genomic-analysis-reveals-the-presence-of-a-class-d-beta-lactamase-with-broad-substrate-specificity-in-animal-bite-associated-capnocytophaga-species
#11
S Zangenah, A F Andersson, V Özenci, P Bergman
Capnocytophga canimorsus and Capnocytophga cynodegmi can be transmitted from cats and dogs to humans, and can cause a wide range of infections including wound infections, sepsis, or endocarditis. We and others recently discovered two new Capnocytophaga species, C. canis and C. stomatis, mainly associated with wound infections. The first-line treatment of animal bite related infections is penicillin, and in case of allergy, doxycycline and trimethoprim/sulfamethoxazole. However, there is a lack of antibiotic susceptibility patterns for animal bite associated Capnocytophaga species...
April 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27900398/-dyspnea-and-skin-rash-in-a-49-year-old-male-patient
#12
I El-Battrawy, U Ansari, M Behnes, W Kirschstein, S Britsch, C Jabbour, C Fastner, V Bill, M Borggrefe, I Akin
We report on the case of a 49-year-old man who presented with increasing dyspnea and a skin rash. The community-acquired pneumonia was initially treated with broad spectrum antibiotics. The patient's respiratory condition rapidly worsened and the clinical picture of Waterhouse-Friderichsen syndrome developed with disseminated intravasal coagulopathy and necrosis of the toes. An infection with Capnocytophaga canimorsus, which had been caused by an initially unmentioned dog bite was confirmed. In view of the fulminant course and the high risk of operative treatment of the ubiquitous necroses in all limbs, a joint decision for deescalation of therapy was made together with relatives...
November 29, 2016: Der Internist
https://www.readbyqxmd.com/read/27795390/identification-of-a-new-lipoprotein-export-signal-in-gram-negative-bacteria
#13
Frédéric Lauber, Guy Richard Cornelis, Francesco Renzi
Bacteria of the phylum Bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (Sus-like systems) involved in carbohydrate acquisition. These complexes have been mostly linked to commensalism, and in some instances, they have also been shown to play a role in pathogenesis. Sus-like systems are mainly composed of lipoproteins anchored to the outer membrane and facing the external milieu. This lipoprotein localization is uncommon in most studied Gram-negative bacteria, while it is widespread in Bacteroidetes Little is known about how these complexes assemble and particularly about how lipoproteins reach the bacterial surface...
October 25, 2016: MBio
https://www.readbyqxmd.com/read/27786617/comparison-of-two-different-sampling-methods-for-subgingival-plaque-subgingival-paper-points-or-mouthrinse-sample
#14
Katrin Nickles, Susanne Scharf, Lasse Röllke, Bettina Dannewitz, Peter Eickholz
OBJECTIVE: The collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. The collection of saliva, however, is simple and contains pathogens of all intraoral surfaces. The aim of this study is to investigate whether sampling with a mouthrinse (mouthrinse sample/MSP; test) leads to comparable results as the standard sampling method (multiple site test from the deepest pocket of each quadrant/MT4; control). METHODS: In 50 patients with periodontitis, subgingival plaque was sampled from the deepest pocket of each quadrant by using paper points and by gaining saliva with a saline mouthrinse...
October 27, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27762095/evaluation-of-new-chlorhexidine-and-cetylpyridinium-chloride-based-mouthrinse-formulations-adjunctive-to-scaling-and-root-planing-pilot-study
#15
M García-Gargallo, M Zurlohe, E Montero, B Alonso, J Serrano, M Sanz, D Herrera
OBJECTIVE: To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested. METHODS: A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0...
October 20, 2016: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/27704003/diagnosis-of-capnocytophaga-canimorsus-sepsis-by-whole-genome-next-generation-sequencing
#16
Maria K Abril, Adam S Barnett, Kara Wegermann, Eric Fountain, Andrew Strand, Benjamin M Heyman, Britton A Blough, Aparna C Swaminathan, Batu Sharma-Kuinkel, Felicia Ruffin, Barbara D Alexander, Chad M McCall, Sylvia F Costa, Murat O Arcasoy, David K Hong, Timothy A Blauwkamp, Michael Kertesz, Vance G Fowler, Bryan D Kraft
We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27666996/supragingival-plaque-microbial-community-analysis-of-children-with-halitosis
#17
Wen Ren, Qun Zhang, Xuenan Liu, Shuguo Zheng, Lili Ma, Feng Chen, Tao Xu, Baohua Xu
As one of the most complex human-associated microbial habitats, the oral cavity harbors hundreds of bacteria. Halitosis is a prevalent oral condition that is typically caused by bacteria. The aim of this study was to analyze the microbial communities and predict functional profiles in supragingival plaque from healthy individuals and those with halitosis. Ten preschool children were enrolled in this study; five with halitosis and five without. Supragingival plaque was isolated from each participant and 16S rRNA gene pyrosequencing was used to identify the microbes present...
December 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27660886/benefits-of-bifidobacterium-animalis-subsp-lactis-probiotic-in-experimental-periodontitis
#18
Luiz F F Oliveira, Sérgio L Salvador, Pedro H F Silva, Flávia A C Furlaneto, Luciene Figueiredo, Renato Casarin, Edilson Ervolino, Daniela B Palioto, Sérgio L S Souza, Mario Taba, Arthur B Novaes, Michel R Messora
BACKGROUND: This study evaluates effects of topical administration of probiotic bacteria of the genus Bifidobacterium on experimental periodontitis (EP) in rats. METHODS: Thirty-two rats were divided into groups C (control; without EP), EP (EP only), C-HN019 (control+probiotic), and EP-HN019 (EP+probiotic). On day 0 of the experiment, animals of groups EP and EP-HN019 received cotton ligatures around mandibular first molars (MFMs). In groups C-HN019 and EP-HN019, 1 mL of suspensions containing Bifidobacterium animalis subsp...
February 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/27629977/capnocytophaga-ochracea-related-bacterium-bacteremia-in-a-hypertrophic-cardiomyopathy-patient-without-neutropenia
#19
Shimpei Ito, Hideharu Hagiya, Keigo Kimura, Isao Nishi, Hisao Yoshida, Hidetaka Kioka, Tomohito Ohtani, Osamu Yamaguchi, Kazuaki Tanabe, Kazunori Tomono, Yasushi Sakata
Gram-negative fusiform rods were detected in a blood culture obtained from a 63-year-old man who had been hospitalized for a long duration for severe heart failure. Although the organism could not be identified using a conventional method, it was finally identified as a bacterium of the Capnocytophaga ochracea group based on the results of biochemical testing, 16S rRNA sequencing and a matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis. Although neutropenic patients with poor oral hygiene are exclusively vulnerable to Capnocytophaga bacteremia, this case was unique because such predisposing conditions were not noted...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27581861/-pets-are-a-risk-for-asplenic-patients-capnocytophaga-canimorsus-infection-in-an-asplenic-patient
#20
R I Claassen, C Savelkoul, M A Schouten, D H T Tjan
Post-splenectomy sepsis is a serious condition with high mortality rates. We present a case of a 64-year-old patient with a medical history of splenectomy who was referred to the Emergency Department with a fever, shivers, and an altered mental state. The symptoms had started twelve hours before. Upon arrival in the hospital the patient was tachypnoeic, hypotensive and febrile. Blood cultures were taken and broad-spectrum antibiotics were started. He was directly admitted to the Intensive Care Unit with severe sepsis of unknown aetiology...
2016: Nederlands Tijdschrift Voor Geneeskunde
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