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https://www.readbyqxmd.com/read/29156873/prevention-of-propofol-injection-related-pain-using-pretreatment-transcutaneous-electrical-acupoint-stimulation
#1
Luping Huang, Yuanyuan Pan, Sijia Chen, Münyuan Zhang, Xiuxiu Zhuang, Shenhui Jin, Junlu Wang, Qinxue Dai, Yunchang Mo
Background/aim: This study aimed to study the effect of pretreatment transcutaneous electrical acupoint stimulation (TEAS) in preventing propofol injection-related pain. Materials and methods: A total of 360 patients who were to undergo elective hysteroscopy surgery were randomly divided into the following three groups of 120 patients each: control (Group C), sham TEAS (Group F), and TEAS (Group T). Patients in Group C did not undergo any treatment before surgery; 30 min before the induction of anesthesia, patients in Groups F and T underwent electrical stimulation of the bilateral LI4-PC6 acupoint...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156859/relationship-of-paratracheal-lymph-nodes-with-the-progression-of-chronic-autoimmune-thyroiditis-5-year-follow-up-results
#2
Gülhan Akbaba, Dilek Berker, Serhat Işık, Narin Nasıroğlu İmga, Ferit Kerim Küçükler, Yasemin Tütüncü, Serdar Güler
Background/aim: To examine changes in paratracheal lymph nodes (PLNs) and the relationship with the course of the disease in patients with chronic autoimmune thyroiditis (CAT) 5 years after diagnosis. Materials and methods: A total of 169 patients with newly diagnosed CAT and 53 healthy subjects were included in the study. All patients underwent ultrasonographic (US) examinations of the thyroid, paratracheal regions, and examined thyroid function tests. Eighty-four patients who were euthyroid at baseline and who were contacted 5 years after the diagnosis were reevaluated by US and thyroid function tests...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156847/longitudinal-relationship-between-traumatic-brain-injury-and-the-risk-of-incident-optic-neuropathy-a-10-year-follow-up-nationally-representative-taiwan-survey
#3
Ying-Jen Chen, Chang-Min Liang, Ming-Cheng Tai, Yun-Hsiang Chang, Tzu-Yu Lin, Chi-Hsiang Chung, Fu-Huang Lin, Chang-Huei Tsao, Wu-Chien Chien
Accumulating evidences had shown that traumatic brain injury was associated with visual impairment or vision loss. However, there were a limited number of empirical studies regarding the longitudinal relationship between traumatic brain injury and incident optic neuropathy. We studied a cohort from the Taiwanese National Health Insurance data comprising 553918 participants with traumatic brain injury and optic neuropathy-free in the case group and 1107836 individuals without traumatic brain injury in the control group from 1st January 2000...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156839/the-benefit-of-immunonutrition-in-patients-undergoing-hepatectomy-a-systematic-review-and-meta-analysis
#4
Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Bowen Wang, Ning Sun, Jialin Zhang
Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156826/protective-effect-of-ginkgo-biloba-leaves-extract-egb761-on-myocardium-injury-in-ischemia-reperfusion-rats-via-regulation-of-tlr-4-nf-%C3%AE%C2%BAb-signaling-pathway
#5
Yuping Tang, Guisheng Zhou, Lijun Yao, Ping Xue, Danhong Yu, Renjie Xu, Wen Shi, Xin Yao, Zhaowei Yan, Jin-Ao Duan
Beneficial actions of EGb 761 against ischemia/reperfusion (I/R) injury in lung, brain and renal ischemia have been described. However, the relationship between EGb 761 and signal molecules in myocardial ischemia reperfusion has not been well elucidated. In this study, we investigated the effects and mechanism of EGb 761 preconditioning on anti-myocardial I/R injuries in vivo. Meanwhile, their potential anti-oxidative stress and anti-inflammation effect were assessed. Hemodynamic parameters were monitored as left ventricular systolic pressure, LV end-diastolic pressure and maximal rate of increase and decrease of left ventricular pressure (dP/dtmax)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156824/37-kda-lrp-flag-enhances-telomerase-activity-and-reduces-senescent-markers-in-vitro
#6
Tyrone C Otgaar, Eloise Ferreira, Sibusiso Malindisa, Martin Bernert, Boitelo T Letsolo, Stefan F T Weiss
One of the core regulators of cellular aging are telomeres, repetitive DNA sequences at the ends of chromosomes that are maintained by the ribonucleoprotein DNA polymerase complex, telomerase. Recently, we demonstrated that knockdown of the 37kDa/ 67kDa laminin receptor (LRP/LR), a protein that promotes cell viability in tumorigenic and normal cells, reduces telomerase activity. We therefore hypothesized that upregulating LRP/LR might increase telomerase activity and impede aging. Here we show that overexpression of LRP::FLAG resulted in significantly elevated hTERT levels, telomerase activity and telomere length, respectively, with concomitantly reduced levels of senescence markers...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156816/mixed-subtype-thyroid-cancer-a-surveillance-epidemiology-and-end-results-database-analysis
#7
Chunping Liu, Qiuyang Zhao, Zhi Li, Shuntao Wang, Yiquan Xiong, Zeming Liu, Tao Huang
The prognosis of patients with mixed subtype thyroid cancer (MSTC) is unclear. The present study compared the prognoses of MSTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC) to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Patient mortality was evaluated using Cox proportional hazards regression analyses and Kaplan-Meier analyses with log-rank tests...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156784/marital-status-and-survival-of-patients-with-kidney-cancer
#8
Tingru Miao, Yufeng Li, Xiaoli Sheng, Dingguo Yao
Background: The relationship between marital status and prognosis of kidney cancer has not been explored in detail. In this study, we aimed to investigate the impact of marital status on survival outcomes in kidney cancer. Methods: We used the Surveillance, Epidemiology and End Results (SEER) program to identify 112860 patients with kidney cancer diagnosed in 2004 through 2013. Kaplan-Meier methods and multivariable Cox regression models were used to analyze the influence of marital status on overall survival (OS) and cancer-specific survival (CSS)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156770/sco-spondin-oligopeptide-inhibits-angiogenesis-in-glioblastoma
#9
Romain Bibes, Stéphane Gobron, François Vincent, Carole Mélin, Nicolas Vedrenne, Aurélie Perraud, Francois Labrousse, Marie-Odile Jauberteau, Fabrice Lalloué
Angiogenesis plays a critical role in glioblastoma growth and progression. We therefore aimed at evaluating the anti-angiogenic properties of an oligopeptide originating from SCO-spondin (NX) on a model of human glioblastoma. To this end, we studied the impact of NX treatment on human brain endothelial cells (HBMECs) alone or co-cultured with glioblastoma cells (U87-MG) on apoptosis, proliferation, migration and release of angiogenic factors. We further investigated the anti-angiogenic potential of NX on human glioblastoma cells grown on chorio-allantoic membrane (CAM) or in glioblastoma xenografts...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156745/predictive-value-of-preoperative-inflammatory-response-biomarkers-for-metabolic-syndrome-and-post-pcnl-systemic-inflammatory-response-syndrome-in-patients-with-nephrolithiasis
#10
Kun Tang, Haoran Liu, Kehua Jiang, Tao Ye, Libin Yan, Peijun Liu, Ding Xia, Zhiqiang Chen, Hua Xu, Zhangqun Ye
Neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) were promising biomarkers used to predict diagnosis and prognosis in various inflammatory responses diseases and cancers. However, there have been no reports regarding these biomarkers in kidney stone patients. This study aimed to evaluate the predictive value of inflammatory biomarkers for metabolic syndrome (MetS) and post-PCNL SIRS in nephrolithiasis patients...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156654/a-dual-band-frequency-reconfigurable-origami-magic-cube-antenna-for-wireless-sensor-network-applications
#11
Syed Imran Hussain Shah, Sungjoon Lim
In this paper, a novel dual band frequency reconfigurable antenna using an origami magic cube is proposed for wireless sensor network (WSN) applications. The proposed origami antenna consists of a meandered monopole folded onto three sides of the magic cube. A microstrip open-ended stub is loaded on the meandered monopole. The proposed origami magic cube can be mechanically folded and unfolded. The proposed antenna operates at 1.57 GHZ and 2.4 GHz in the folded state. In the unfolded state, the proposed antenna operates at 900 MHz and 2...
November 20, 2017: Sensors
https://www.readbyqxmd.com/read/29156644/akt1-stimulates-homologous-recombination-repair-of-dna-double-strand-breaks-in-a-rad51-dependent-manner
#12
Katharina Mueck, Simone Rebholz, Mozhgan Dehghan Harati, H Peter Rodemann, Mahmoud Toulany
Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-induced DSBs in non-small cell lung cancer (NSCLC) cells A549 and H460. Akt1-knockdown (Akt1-KD) significantly reduced Rad51 protein level, Rad51 foci formation and its colocalization with γH2AX foci after irradiation. Moreover, Akt1-KD decreased clonogenicity after treatment with Mitomycin C and HR repair, as tested by an HR-reporter assay...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156624/evaluation-of-posaconazole-pharmacokinetics-in-adult-patients-with-invasive-fungal-infection
#13
Sarah Allegra, Giovanna Fatiguso, Silvia De Francia, Fabio Favata, Elisa Pirro, Chiara Carcieri, Amedeo De Nicolò, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
Mortality and morbidity due to invasive fungal infections have increased over the years. Posaconazole is a second-generation triazole agent with an extended spectrum of activity, which shows a high interindividual variability in its plasma levels, rendering dosing in many patients inconsistent or inadequate. Hence, posaconazole therapeutic drug monitoring, which is easily available in clinical practice, may improve treatment success and safety. The aim of the study was to describe posaconazole pharmacokinetics, and to evaluate the utility of therapeutic drug monitoring for therapy and prophylaxis in a cohort of adult patients...
November 20, 2017: Biomedicines
https://www.readbyqxmd.com/read/29156622/advanced-glycation-end-products-in-the-pathogenesis-of-psoriasis
#14
REVIEW
Anastasia Papagrigoraki, Martina Maurelli, Micol Del Giglio, Paolo Gisondi, Giampiero Girolomoni
Advanced glycation end products (AGEs) are extremely oxidant and biologically reactive compounds, which form through oxidation of sugars, lipids and amino acids to create aldehydes that bind covalently to proteins. AGEs formation and accumulation in human tissues is a physiological process during ageing but it is enhanced in case of persistent hyperglycemia, hyperlipidemia and oxidative or carbonyl stress, which are common in patients with moderate to severe psoriasis. Exogenous AGEs may derive from foods, UV irradiation and cigarette smoking...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156616/a-novel-mutation-in-the-fibrinogen-b%C3%AE-chain-c-490g-a-end-of-exon-3-causes-a-splicing-abnormality-and-ultimately-leads-to-congenital-hypofibrinogenemia
#15
Chiaki Taira, Kazuyuki Matsuda, Shinpei Arai, Mitsutoshi Sugano, Takeshi Uehara, Nobuo Okumura
We found a novel heterozygous mutation in the fibrinogen Bβ chain (c.490G>A) of a 3-year-old girl with congenital hypofibrinogenemia. To clarify the complex genetic mechanism, we made a mini-gene including a FGB c.490G>A mutation region, transfected it into a Chinese Hamster Ovary (CHO) cell line, and analyzed reverse transcription (RT) products. The assembly process and secretion were examined using recombinant mutant fibrinogen. Direct sequencing demonstrated that the mutant RT product was 99 bp longer than the wild-type product, and an extra 99 bases were derived from intron 3...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156607/calcium-dependent-protein-kinases-in-phytohormone-signaling-pathways
#16
REVIEW
Wuwu Xu, Wenchao Huang
Calcium-dependent protein kinases (CPKs/CDPKs) are Ca(2+)-sensors that decode Ca(2+) signals into specific physiological responses. Research has reported that CDPKs constitute a large multigene family in various plant species, and play diverse roles in plant growth, development, and stress responses. Although numerous CDPKs have been exhaustively studied, and many of them have been found to be involved in plant hormone biosynthesis and response mechanisms, a comprehensive overview of the manner in which CDPKs participate in phytohormone signaling pathways, regulating nearly all aspects of plant growth, has not yet been undertaken...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156602/assembled-cantilever-fiber-touch-trigger-probe-for-three-dimensional-measurement-of-microstructures
#17
Limin Zou, He Ni, Peng Zhang, Xuemei Ding
In this paper, an assembled cantilever fiber touch trigger probe was developed for three-dimensional measurements of clear microstructures. The probe consists of a shaft assembled vertically to an optical fiber cantilever and a probing sphere located at the free end of the shaft. The laser is emitted from the free end of the fiber cantilever and converges on the photosensitive surface of the camera through the lens. The position shift of the light spot centroid was used to detect the performance of the optical fiber cantilever, which changed dramatically when the probing sphere touched the objects being measured...
November 20, 2017: Sensors
https://www.readbyqxmd.com/read/29156442/charting-a-path-towards-non-destructive-biomarkers-in-threatened-wildlife-a-systematic-quantitative-literature-review
#18
REVIEW
Stephanie Chaousis, Frederic D L Leusch, Jason P van de Merwe
Threatened species are susceptible to irreversible population decline caused by adverse sub-lethal effects of chemical contaminant exposure. It is therefore vital to develop the necessary tools to predict and detect these effects as early as possible. Biomarkers of contaminant exposure and effect are widely applied to this end, and a significant amount of research has focused on development and validation of sensitive and diagnostic biomarkers. However, progress in the use biomarkers that can be measured using non-destructive techniques has been relatively slow and there are still many difficulties to overcome in the development of sound methods...
November 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29156416/the-natural-context-of-wellbeing-ecological-momentary-assessment-of-the-influence-of-nature-and-daylight-on-affect-and-stress-for-individuals-with-depression-levels-varying-from-none-to-clinical
#19
Femke Beute, Yvonne A W de Kort
This paper explores how everyday encounters with two natural phenomena -natural elements and daylight- influence affect and stress levels for people differing in mental health. Nature and daylight exposure both have well-documented beneficial effects on mental health and affect but to what extent their exposure has beneficial effects in daily life is currently under investigated, as is the question whether lower mental health would make one more, or instead, less responsive. To this end, an ecological momentary assessment protocol was employed for a period of 6 days...
November 17, 2017: Health & Place
https://www.readbyqxmd.com/read/29156412/a-system-level-mathematical-model-of-basal-ganglia-motor-circuit-for-kinematic-planning-of-arm-movements
#20
Armin Salimi-Badr, Mohammad Mehdi Ebadzadeh, Christian Darlot
In this paper, a novel system-level mathematical model of the Basal Ganglia (BG) for kinematic planning, is proposed. An arm composed of several segments presents a geometric redundancy. Thus, selecting one trajectory among an infinite number of possible ones requires overcoming redundancy, according to some kinds of optimization. Solving this optimization is assumed to be the function of BG in planning. In the proposed model, first, a mathematical solution of kinematic planning is proposed for movements of a redundant arm in a plane, based on minimizing energy consumption...
November 10, 2017: Computers in Biology and Medicine
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