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https://www.readbyqxmd.com/read/28103612/a-phase-iii-randomised-controlled-trial-of-erlotinib-vs-gefitinib-in-advanced-non-small-cell-lung-cancer-with-egfr-mutations
#1
J J Yang, Q Zhou, H H Yan, X C Zhang, H J Chen, H Y Tu, Z Wang, C R Xu, J Su, B C Wang, B Y Jiang, X Y Bai, W Z Zhong, X N Yang, Y L Wu
BACKGROUND: A phase III trial was conducted to compare the safety and efficacy of erlotinib with that of gefitinib in advanced non-small cell lung cancer harbouring epidermal growth factor receptor mutations in exon 19 or 21. METHODS: Eligible patients were randomised to receive erlotinib (150 mg per day) or gefitinib (250 mg per day) orally until disease progression or unacceptable toxicity. We aimed to determine whether erlotinib is superior to gefitinib in efficacy...
January 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28103576/a-new-model-of-multi-visceral-and-bone-metastatic-prostate-cancer-with-perivascular-niche-targeting-by-a-novel-endothelial-specific-adenoviral-vector
#2
Zhi Hong Lu, Sergey Kaliberov, Rebecca E Sohn, Lyudmila Kaliberova, Yingqiu Du, Julie L Prior, Daniel J Leib, Anne Chauchereau, Jennifer K Sehn, David T Curiel, Jeffrey M Arbeit
While modern therapies for metastatic prostate cancer (PCa) have improved survival they are associated with an increasingly prevalent entity, aggressive variant PCa (AVPCa), lacking androgen receptor (AR) expression, enriched for cancer stem cells (CSCs), and evidencing epithelial-mesenchymal plasticity with a varying extent of neuroendocrine transdifferentiation. Parallel work revealed that endothelial cells (ECs) create a perivascular CSC niche mediated by juxtacrine and membrane tethered signaling. There is increasing interest in pharmacological metastatic niche targeting, however, targeted access has been impossible...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103548/dimensionality-reduction-on-spd-manifolds-the-emergence-of-geometry-aware-methods
#3
Mehrtash Harandi, Mathieu Salzmann, Richard Hartley
Representing images and videos with Symmetric Positive Definite (SPD) matrices, and considering the Riemannian geometry of the resulting space, has been shown to yield high discriminative power in many visual recognition tasks. Unfortunately, computation on the Riemannian manifold of SPD matrices -especially of high-dimensional ones- comes at a high cost that limits the applicability of existing techniques. In this paper, we introduce algorithms able to handle high-dimensional SPD matrices by constructing a lower-dimensional SPD manifold...
January 18, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103530/an-anti-oxidant-%C3%AE-lipoic-acid-conjugated-oleoyl-sn-phosphatidylcholineas-a-helper-lipid-in-cationic-liposomal-formulations
#4
Priya Dharmalingam, Balakrishna Marrapu, Chandrashekhar Voshavar, Rasagna Nadella, Vignesh Kumar Rangasami, R V Shaji, Salar Abbas, R B N Prasad, Shiva Shanker Kaki, Srujan Marepally
Development of safe non-viral carrier systems for efficient intra-cellular delivery of drugs and genes hold promise in the area of translational research. Liposome based delivery systems have emerged as one of the attractive strategies for efficient delivery of drugs and nucleic acids. To this end, number of investigations was carried on liposomal formulations using lipids for achieving higher efficiency in transfection with lower cytotoxicities. In our efforts to develop safer and efficient liposomal delivery systems, we synthesized a novel anti-oxidant lipid, α-lipoyl, oleyl-sn-phosphatidylcholine (LOPC) and used as a helper lipid in combination with a cationic amphiphile, Di-Stearyl Dihydroxy Ethyl Ammonium Chloride (DSDEAC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) at varying concentrations of LOPC...
January 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103468/poly-a-binding-proteins-are-required-for-translational-regulation-in-vertebrate-oocytes-and-early-embryos
#5
Saffet Ozturk, Fatma Uysal
Poly(A)-binding proteins (PABPs) function in the timely regulation of gene expression during oocyte maturation, fertilisation and early embryo development in vertebrates. To this end, PABPs bind to poly(A) tails or specific sequences of maternally stored mRNAs to protect them from degradation and to promote their translational activities. To date, two structurally different PABP groups have been identified: (1) cytoplasmic PABPs, including poly(A)-binding protein, cytoplasmic 1 (PABPC1), embryonic poly(A)-binding protein (EPAB), induced PABP and poly(A)-binding protein, cytoplasmic 3; and (2) nuclear PABPs, namely embryonic poly(A)-binding protein 2 and nuclear poly(A)-binding protein 1...
January 20, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28103448/bedside-contribution-of-electrical-impedance-tomography-to-set-positive-end-expiratory-pressure-for-ecmo-treated-severe-ards-patients
#6
Guillaume Franchineau, Nicolas Bréchot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
RATIONALE: Optimal positive end-expiratory pressure (PEEP) is unknown in severe acute respiratory distress syndrome (ARDS) patients on extracorporeal membrane oxygenation (ECMO) receiving mechanical ventilation with very low tidal volume. OBJECTIVES: To evaluate electrical impedance tomography's (EIT) ability to monitor a PEEP trial and to derive from EIT the best compromise PEEP in this setting. METHODS: A decremental PEEP trial (20-0 cmH2O) in 5 cmH2O steps was monitored by EIT, with lung images divided into four ventral-to-dorsal horizontal regions of interest...
January 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28103398/cognitive-behavioral-and-psycho-social-factors-associated-with-successful-and-maintained-quit-smoking-status-among-patients-who-received-smoking-cessation-intervention-with-nurses-counseling
#7
Chie Taniguchi, Hideo Tanaka, Hideo Saka, Isao Oze, Kazunobu Tachibana, Yasuhiro Nozaki, Yukio Suzuki, Hisataka Sakakibara
AIM: To identify cognitive, behavioral and psycho-social factors associated with successful and maintained quit smoking status after patients received smoking cessation intervention with nurses' counseling. BACKGROUND: Although nurses' intervention for smoking cessation is effective for patients, few studies have been conducted to identify cognitive, behavioral and psycho-social factors associated with the success of quitting smoking. DESIGN: Prospective cohort study METHODS: In a multi-institutional study between October 2008 - October 2014, we administered the Japanese smoking cessation therapy, which consists of smoking cessation intervention five times with nurses' counseling over 12 weeks...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28103312/increased-cardiovascular-events-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients-1-year-prospective-single-centre-study
#8
Piero Ruscitti, Paola Cipriani, Francesco Masedu, Silvio Romano, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Di Benedetto, Saverio Alvaro, Maria Penco, Marco Valenti, Roberto Giacomelli
OBJECTIVES: Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the occurrence of new CVEs and the onset of subclinical atherosclerosis. METHODS: We designed a single centre, bias-adjusted, prospective, observational study to investigate, in a homogeneous subset of RA patients, the occurrence of new onset of CVEs and subclinical atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28103303/driving-with-intuition-a-preregistered-study-about-the-eeg-anticipation-of-simulated-random-car-accidents
#9
Gian Marco Duma, Giovanni Mento, Tommaso Manari, Massimiliano Martinelli, Patrizio Tressoldi
The study of neural pre-stimulus or "anticipatory" activity opened a new window for understanding how the brain actively constructs the forthcoming reality. Usually, experimental paradigms designed to study anticipatory activity make use of stimuli. The purpose of the present study is to expand the study of neural anticipatory activity upon the temporal occurrence of dichotomic, statistically unpredictable (random) stimuli within an ecological experimental paradigm. To this purpose, we used a simplified driving simulation including two possible, randomly-presented trial types: a car crash end trial and a no car crash end trial...
2017: PloS One
https://www.readbyqxmd.com/read/28103233/evaluation-of-a-smartphone-decision-support-tool-for-diarrheal-disease-management-in-a-resource-limited-setting
#10
Farhana Haque, Robyn L Ball, Selina Khatun, Mujaddeed Ahmed, Saraswati Kache, Mohammod Jobayer Chisti, Shafiqul Alam Sarker, Stace D Maples, Dane Pieri, Teja Vardhan Korrapati, Clea Sarnquist, Nancy Federspiel, Muhammad Waliur Rahman, Jason R Andrews, Mahmudur Rahman, Eric Jorge Nelson
The emergence of mobile technology offers new opportunities to improve clinical guideline adherence in resource-limited settings. We conducted a clinical pilot study in rural Bangladesh to evaluate the impact of a smartphone adaptation of the World Health Organization (WHO) diarrheal disease management guidelines, including a modality for age-based weight estimation. Software development was guided by end-user input and evaluated in a resource-limited district and sub-district hospital during the fall 2015 cholera season; both hospitals lacked scales which necessitated weight estimation...
January 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28103196/sensor-based-gait-parameter-extraction-with-deep-convolutional-neural-networks
#11
Julius Hannink, Thomas Kautz, Cristian Pasluosta, Karl-Gunter Gassmann, Jochen Klucken, Bjoern Eskofier
Measurement of stride-related, biomechanical parameters is the common rationale for objective gait impairment scoring. State-of-the-art double integration approaches to extract these parameters from inertial sensor data are, however, limited in their clinical applicability due to the underlying assumptions. To overcome this, we present a method to translate the abstract information provided by wearable sensors to context-related expert features based on deep convolutional neural networks. Regarding mobile gait analysis, this enables integration-free and data-driven extraction of a set of eight spatio-temporal stride parameters...
December 8, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103155/using-art-in-an-intergenerational-program-to-improve-students-attitudes-toward-people-with-dementia
#12
Elizabeth Lokon, Yue Li, Jyotsana Parajuli
This study explored the effects of participating in an intergenerational service learning program called Opening Mind through Arts (OMA) on college students' attitudes toward people with dementia. In this program, students were paired one-on-one with elders who have dementia to support the elders' creation of visual art projects. They met weekly for one semester. The Dementia Attitude Scale was administered at the beginning and end of the semester to measure changes in students' attitudes. The study included 156 students participating in OMA and assessed if their participation makes a difference in the degree of change in overall attitudes, knowledge and comfort level toward people with dementia...
January 19, 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/28103137/cap-gly-proteins-contribute-to-microtubule-dependent-trafficking-via-interactions-with-the-c-terminal-aromatic-residue-of-%C3%AE-tubulin
#13
Annie Andrieux, Laurence Aubry, Cécile Boscheron
In mammals, the C-terminal tyrosine residue of α-tubulin is subjected to removal/re-addition cycles resulting in tyrosinated microtubules and detyrosinated Glu-microtubules. CLIP170 and its yeast ortholog (Bik1) interact weakly with Glu-microtubules. Recently, we described a Microtubule- Rho1- and Bik1-dependent mechanism involved in Snc1 routing. Here, we further show a contribution of the yeast p150Glued ortholog (Nip100) in Snc1 trafficking. Both CLIP170 and p150Glued are CAP-Gly-containing proteins that belong to the microtubule +end-tracking protein family (known as +Tips)...
January 19, 2017: Small GTPases
https://www.readbyqxmd.com/read/28103073/multilevel-prevention-trial-of-alcohol-use-among-american-indian-and-white-high-school-students-in-the-cherokee-nation
#14
Kelli A Komro, Melvin D Livingston, Alexander C Wagenaar, Terrence K Kominsky, Dallas W Pettigrew, Brady A Garrett
OBJECTIVES: To evaluate the effectiveness of a multilevel intervention designed to prevent underage alcohol use among youths living in the Cherokee Nation. METHODS: We randomly assigned 6 communities to a control, Communities Mobilizing for Change on Alcohol (CMCA; a community-organizing intervention targeting alcohol access) only, CONNECT (a school-based universal screening and brief intervention) only, or a combined condition. We collected quarterly surveys 2012-2015 from students starting in 9th and 10th grades and ending in 11th and 12th grades...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28103034/a-comparison-of-gallium-and-indium-alkoxide-complexes-as-catalysts-for-ring-opening-polymerization-of-lactide
#15
Alexandre B Kremer, Ryan J Andrews, Matthew J Milner, Xu R Zhang, Tannaz Ebrahimi, Brian O Patrick, Paula L Diaconescu, Parisa Mehrkhodavandi
The impact of the metal size and Lewis acidity on the polymerization activity of group 13 metal complexes was studied, and it was shown that, within the same ligand family, indium complexes are far more reactive and selective than their gallium analogues. To this end, gallium and aluminum complexes supported by a tridentate diaminophenolate ligand, as well as gallium complexes supported by N,N'-ethylenebis(salicylimine)(salen) ligands, were synthesized and compared to their indium analogues. Using the tridentate ligand set, it was possible to isolate the gallium chloride complexes 3 and (±)-4 and the aluminum analogues 5 and (±)-6...
January 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28103014/reactive-oxygen-species-and-glutathione-dual-redox-responsive-supramolecular-assemblies-with-controllable-release-capability
#16
Yang Kang, Xin Ju, Li-Sheng Ding, Sheng Zhang, Bang-Jing Li
A dual redox and bio-relevant triggered supramolecular system is developed through the non-covalent host-guest interactions between the ferrocene (Fc) on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). The two segments can form a stable non-covalent supramolecular block copolymer mPEG-β-CD/Fc-CPT, which could further self-assemble into stable micelles in aqueous solution. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells, while the cytotoxicity evaluation of mPEG-β-CD indicated good biocompatibility...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28102958/sliding-window-prior-data-assisted-compressed-sensing-for-mri-tracking-of-lung-tumors
#17
Eugene Yip, Jihyun Yun, Keith Wachowicz, Zsolt Gabos, Satyapal Rathee, B G Fallone
PURPOSE: Hybrid magnetic resonance imaging and radiation therapy devices are capable of imaging in real-time to track intrafractional lung tumor motion during radiotherapy. Highly accelerated magnetic resonance (MR) imaging methods can potentially reduce system delay time and/or improves imaging spatial resolution, and provide flexibility in imaging parameters. Prior Data Assisted Compressed Sensing (PDACS) has previously been proposed as an acceleration method that combines the advantages of 2D compressed sensing and the KEYHOLE view-sharing technique...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102947/a-feasibility-study-of-an-integrated-nir-gamma-visible-imaging-system-for-endoscopic-sentinel-lymph-node-mapping
#18
Han Gyu Kang, Ho-Young Lee, Kyeong Min Kim, Seong-Hyun Song, Gun Chul Hong, Seong Jong Hong
PURPOSE: The aim of this study is to integrate NIR, gamma, and visible imaging tools into a single endoscopic system to overcome the limitation of NIR using gamma imaging and to demonstrate the feasibility of endoscopic NIR/gamma/visible fusion imaging for sentinel lymph node (SLN) mapping with a small animal. METHODS: The endoscopic NIR/gamma/visible imaging system consists of a tungsten pinhole collimator, a plastic focusing lens, a BGO crystal (11 × 11 × 2 mm(3) ), a fiber-optic taper (front = 11 × 11 mm(2) , end = 4 × 4 mm(2) ), a 122-cm long endoscopic fiber bundle, an NIR emission filter, a relay lens, and a CCD camera...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102878/pulmonary-hypertension-associated-with-left-sided-heart-disease
#19
Micha Tobias Maeder, Otto D Schoch, Rebekka Kleiner, Lucas Joerg, Daniel Weilenmann, Swiss Society For Pulmonary Hypertension
Pulmonary hypertension associated with left-sided heart disease (PH-LHD) is the most common type of pulmonary hypertension. In patients with left-sided heart disease, the presence of pulmonary hypertension is typically a marker of more advanced disease, more severe symptoms, and worse prognosis. In contrast to pulmonary arterial hypertension, PH-LHD is characterised by an elevated pulmonary artery wedge pressure (postcapillary pulmonary hypertension) without or with an additional precapillary component (isolated postcapillary versus combined postcapillary and precapillary pulmonary hypertension)...
January 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28102827/a-low-cost-scalable-current-sensing-digital-headstage-for-high-channel-count-%C3%A2%C2%B5ecog
#20
Michael Trumpis, Michele Insanally, Jialin Zou, Ashraf ElSharif, Ali Ghomashchi, N Sertac Artan, Robert Froemke, Jonathan Viventi
OBJECTIVE: High channel count electrode arrays allow for the monitoring of large-scale neural activity at high spatial resolution. Implantable arrays featuring many recording sites require compact, high bandwidth front-end electronics. In the present study, we investigated the use of a small, light weight, and low cost digital current-sensing integrated circuit for acquiring cortical surface signals from a 61-channel micro-electrocorticographic (��ECoG) array. APPROACH: We recorded both acute and chronic ��ECoG signal from rat auditory cortex using our novel digital current-sensing headstage...
January 19, 2017: Journal of Neural Engineering
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