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Peyronies

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https://www.readbyqxmd.com/read/28280315/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-patient-selection-and-perspectives
#1
REVIEW
Paige K Kuhlmann, Kenneth J DeLay, James Anaissie, Wayne Jg Hellstrom, Faysal A Yafi
The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28274142/stem-cell-therapy-for-the-treatment-of-peyronie-s-disease
#2
Athanasios Dellis, Athanasios Papatsoris
Like other fibrotic diseases, the cause of Peyronie's disease (PD) is still obscure. Since there is now increasing evidence for the role of Mesenchymal Stem Cells (MSCs) as potential treatment to fibrosis, it is crucial to determine their possible efficacy in the treatment of PD. Areas covered: In this review, the authors summarize the emerging data and published studies regarding the use of SCs for the treatment of PD. The authors provide particular focus on the three-first experimental studies for the use of SCs in rat models as well as the sole two studies undertaken in humans...
April 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28268167/low-intensity-extracorporeal-shockwave-therapy-in-sexual-medicine-a%C3%A2-questionnaire-based-assessment-of-knowledge-clinical-practice-patterns-and-attitudes-in-sexual-medicine-practitioners
#3
Mikkel Fode, Lior Lowenstein, Yacov Reisman
INTRODUCTION: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a treatment option for male sexual dysfunction. However, results have been contradictory. AIM: To investigate the knowledge, practice patterns, and attitudes regarding LI-ESWT among experts in sexual medicine. METHODS: A study-specific questionnaire was handed out at the 18th Congress for the European Society for Sexual Medicine. Participants were queried on their knowledge about LI-ESWT and about their use of the equipment...
March 4, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28262100/sexual-rehabilitation-after-treatment-for-prostate-cancer-part-2-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#4
Andrea Salonia, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Mohit Khera
INTRODUCTION: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer. AIM: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction. METHODS: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016...
March 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258933/contemporary-review-of-grafting-techniques-for-the-surgical-treatment-of-peyronie-s-disease
#5
REVIEW
Georgios Hatzichristodoulou, Daniar Osmonov, Hubert Kübler, Wayne J G Hellstrom, Faysal A Yafi
INTRODUCTION: Peyronie's disease (PD) is a benign fibrotic disorder of the tunica albuginea of the penis, which can cause penile pain, curvature, shortening, erectile dysfunction, and psychological distress. Surgery is indicated when penile curvature prevents satisfactory sexual intercourse. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. AIM: To provide an overview of recent studies reporting outcomes of grafting techniques and to report advances in the development of new grafting materials for PD surgery...
February 28, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28247636/-using-cell-technologies-to-treat-urologic-diseases
#6
P V Glybochko, Yu V Olefir, Yu G Alyaev, D V Butnaru, E A Bezrukov, A A Chaplenko, T M Zharikova
Stem and progenitor cells being introduced into the body have the ability to stimulate regeneration of tissues and organs by differentiating into specialized cells. Stem cell therapy is used in urology to treat various disorders, including erectile dysfunction, urinary incontinence, Peyronies disease, and male infertility. This review presents the results of international preclinical and clinical research on stem cell based medications for treating the above diseases. The most promising appears to be the use of adipose tissue-derived mesenchymal stem cells...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28217460/collagenase-clostridium-histolyticum-intralesional-injections-for-the-treatment-of-peyronie-s-disease-a-safety-profile
#7
EDITORIAL
Sylvia Yan, Tet Yap, Suks Minhas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217459/complications-and-other-concerns-with-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#8
EDITORIAL
Laurence A Levine
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217458/results-of-smsna-survey-regarding-complications-following-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#9
EDITORIAL
Ates Kadioglu, Emre Salabas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217457/expanding-the-role-of-injectable-collagenase-clostridium-histolyticum-for-the-treatment-of-active-phase-peyronie-s-disease
#10
COMMENT
Louis A Aliperti, Akanksha Mehta
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217456/re-results-of-smsna-survey-regarding-complications-following-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#11
COMMENT
Barbara Kahn, Nelson Bennett
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217450/understanding-the-cellular-basis-and-pathophysiology-of-peyronie-s-disease-to-optimize-treatment-for-erectile-dysfunction
#12
REVIEW
Jeffrey Campbell, Raidh Alzubaidi
Erectile dysfunction (ED) is a common condition that significantly impacts a man's physical and psychological well-being. ED is often associated with Peyronie's disease (PD), which is an abnormal curvature of the penis. Delayed treatment of or surgical invention for PD often results in ED and therefore unsatisfied patients. The pathophysiology of PD is incompletely understood, but has been studied extensively and based on our current understanding of PD physiology, many medical treatment options have been proposed...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28208540/re-peyronie-s-disease-and-injectable-collagenase-clostridium-histolyticum-safety-efficacy-and-improvements-in-subjective-symptoms
#13
Allen F Morey
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28187522/survey-of-patient-and-partner-satisfaction-following-collagenase-clostridium-histolyticum-treatment-for-peyronie-s-disease
#14
J Anaissie, F A Yafi, E J Traore, S C Sikka, W J G Hellstrom
Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
March 2017: Andrology
https://www.readbyqxmd.com/read/28093157/re-evidence-based-management-guidelines-on-peyronie-s-disease
#15
Allen F Morey
No abstract text is available yet for this article.
February 2017: Journal of Urology
https://www.readbyqxmd.com/read/28065353/response-and-rebuttal-to-letter-to-the-editor-evidence-based-management-guidelines-on-peyronie-s-disease
#16
Eric Chung
No abstract text is available yet for this article.
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28057983/role-of-extracorporeal-shock-wave-therapy-in-management-of-peyronie-s-disease-a-preliminary-report
#17
Rajendra Kashinath Shimpi, Ravi Jineshkumar Jain
INTRODUCTION: Peyronie's Disease (PD) is a disease causing psycho social trauma to the patient. Multiple treatment options are available with variable results. Extra Corporeal Shock Wave Therapy (ESWT) is a new insight into the non invasive modality of management. It focuses on the mechanism of inducing angiogenesis in the penile cavernous tissue. MATERIALS AND METHODS: The aim of the study is to determine the role of ESWT in the management of PD. The objectives include demonstrating the improvement in mean International Index of Erectile Function Score (IIEFS), improvement in pain score by Visual Analogue Scale (VAS), change in cavernosal artery flow on colour penile Doppler, reduction in plaque size, and improvement in penile curvature degree after the therapy...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28041853/stem-cells-in-male-sexual-dysfunction-are-we-getting-somewhere
#18
REVIEW
Mohammad Ayodhia Soebadi, Uros Milenkovic, Emmanuel Weyne, Fabio Castiglione, Maarten Albersen
INTRODUCTION: Stem cells for sexual disorders are steadily being introduced into clinical trials. Two conditions of importance are the main target for this line of treatment, especially when regarding the wide array of translational and basic science highlighting the potential advantages of regenerative therapy: erectile dysfunction (ED) and more recently Peyronie disease (PD). Cellular therapy offers a treatment modality that might reverse disease progression. It would be used in a curative setting, in contrast to other pharmaceutical agents that are currently available...
December 29, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28004195/the-periprostatic-venous-plexus-an-unusual-source-of-fatal-pulmonary-embolism-during-corporoplasty
#19
Nazario Foschi, Mauro Ragonese, Vincenzo M Grassi, Valentino De Matteis, Fabio De-Giorgio
When a sudden death occurs during a minor surgical intervention, it may require a careful and extensive postmortem investigation. One such case concerns a 61-year-old male patient affected by Peyronie's disease, who died suddenly during a corporoplasty procedure. Autopsy and histologic examinations showed a massive bilateral pulmonary micro-embolism brought on by periprostatic venous plexus thrombosis. The cause of death was attributed to intraoperative fatal pulmonary micro-embolism. Pulmonary thromboembolism is a major cause of death and is known to be a possible complication of surgery...
December 22, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27909612/nonsurgical-treatment-options-in-peyronie-s-disease-2016-update
#20
REVIEW
Raidh A Talib, Mohammed Abdulkareem Ibrahim, Önder Cangüven
Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. In the last 5 years, commonly used oral medications left their places to intralesional therapies. Clostridium collagenase, which is the only Food and Drug Administration (FDA) approved treatment for PD, is now the most prescribed intralesional therapy in the last years...
December 2016: Turkish Journal of Urology
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