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https://www.readbyqxmd.com/read/29774446/contemporary-review-of-peyronie-s-disease-treatment
#1
REVIEW
Edward Capoccia, Laurence A Levine
PURPOSE: To analyze the literature on the current treatment options for Peyronie's disease (PD). RECENT FINDINGS: Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Although a recent study has shown similar outcomes using a modified protocol requiring fewer injections, CCH remains an expensive medication...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29768978/levels-of-serum-trace-elements-in-patients-with-peyronie
#2
Mustafa Gunes, Rahmi Aslan, Recep Eryılmaz, Halit Demir, Kerem Taken
AIM: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. MATERIAL AND METHODS: Thirty Peyronie patients and 26 healthy volunteers were included in the study. In individuals in both groups, levels of serum trace elements (Manganese [Mn], Cu, Cobalt (Co), zinc [Zn], Cd, and iron [Fe]) were determined separately by Atomic Absorption Spectrophotometer method in Yüzüncü Yıl University Central Research Laboratory...
May 17, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29761688/collagenase-clostridium-histolyticum-a-novel-medical-treatment-for-peyronie-s-disease
#3
Amr Abdel Raheem, Mark Johnson, David Ralph, Giulio Garaffa
INTRODUCTION: Peyronie's disease (PD) affects up to 9% of the male population. PD causes scarring of the tunica albuginea of the penis which leads to penile deformity making sexual intercourse difficult or impossible. PD also causes significant psychological, emotional and relationship difficulties for both patient and partner. Up until the licencing of Collagenase clostridium histolyticum (CCH) (Xiapex®, Xiaflex®), surgical correction of the penile deformity was the mainstay of treatment...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29753801/a-comparative-study-between-2-different-grafts-used-as-patches-after-plaque-incision-and-inflatable-penile-prosthesis-implantation-for-end-stage-peyronie-s-disease
#4
Marco Falcone, Mirko Preto, Carlo Ceruti, Massimiliano Timpano, Giulio Garaffa, Omidreza Sedigh, Mattia Sibona, Marco Oderda, Paolo Gontero, Luigi Rolle
BACKGROUND: Although many grafts have been used for plaque incision with grafting (PIG) and penile prosthesis (PP) implantation, there is no evidence that favors 1 specific graft over another. AIM: To compare fibrin-coated collagen fleece (TachoSil; Baxter International, Deerfield, IL, USA) with porcine small intestinal submucosa (SIS; Cook Biotech, West Lafayette, IN, USA) as grafts. METHODS: From January 2007 to January 2015, 60 non-randomized consecutive patients affected by end-stage Peyronie disease underwent PIG and PP implantation (AMS 700CX; Boston Scientific, Marlborough, MA, USA)...
May 9, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29736012/modified-16-dot-plication-technique-for-correction-of-penile-curvature-prevention-of-knot-related-complications
#5
Emad A Salem
Penile curvature is a common urological disease. Tunical plication for correction of penile curvature has been much popularized being simpler, adjustable to avoid overcorrection, less bleeding, and less postoperative erectile dysfunction. This study aims to assess the results of modified 16-dot plication technique for correction of congenital and acquired penile curvature and avoidance of knot-associated complications. Eighteen patients underwent correction of their penile curvature using the modified 16-dot plication technique between January 2014 and October 2015...
May 8, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29734007/collagenase-nanocapsules-an-approach-to-fibrosis-treatment
#6
María Rocío Villegas, Alejandro Baeza, Alicia Usategui, Pablo L Ortiz-Romero, José L Pablos, María Vallet-Regí
Fibrosis is a common lesion in different pathologic diseases and defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. The FDA and EMA approved the use of collagenase to treat palmar fibromatosis (Dupuytren's contracture). The EMA approved additionally its use in severe Peyronie's disease, but it has been used off label in other conditions.[1,2] The approved treatment includes up to three (in palmar fibromatosis) or up to eight (in penile fibromatosis) injections followed by finger extension or penile modeling procedures, typically causing severe pain...
May 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29733116/collagenase-clostridium-histolyticum-for-the-treatment-of-peyronie-s-disease-a-prospective-italian-multicentric-study
#7
M Capece, A Cocci, G Russo, G Cito, G Giubilei, G Cacciamani, G Garaffa, M Falcone, M Timpano, G Tasso, F Sessa, R Campi, F Di Maida, T Cai, G Morelli, B Giammusso, P Verze, A Palmieri, D Ralph, V Mirone, N Mondaini
Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. In five Italian centres, 135 patients have completed the treatment with three injections of CCH using Ralph's shortened modified protocol...
May 7, 2018: Andrology
https://www.readbyqxmd.com/read/29726655/-collagenase-clostridium-histolyticum-for-peyronie-s-disease-a-new-minimally-invasive-and-effective-treatment
#8
REVIEW
Hao-Cheng Lin, Hai-Tao Zhang, Hui Jiang
The treatment of Peyronie's disease has been a challenge to urologists, as most of the current oral medications are considered hardly valid and the rest of the therapies require strict control of indications, some of which remain controversial, while the final surgical option may be associated with complications such as penile shortening or erectile dysfunction. Collagenase clostridium histolyticum has been proved to be effective in dissolving the penile cavernosal plaque and approved by the Food and Drug Administration of the USA as the first drug to be used for the treatment of Peyronie's disease...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29723588/separating-the-wheat-from-the-chaff-an-evaluation-of-readability-quality-and-accuracy-of-online-health-information-for-treatment-of-peyronie-s-disease
#9
Nicholas J Bompastore, Theodore Cisu, Peter Holoch
OBJECTIVES: To characterize available information about Peyronie's disease online and evaluate its readability, quality, accuracy, and respective associations with HONcode certification and website category. METHODS: The search term "Peyronie's disease" was queried on three major search engines (Google, Bing, Yahoo) and the first 50 search results on each search engine were assessed. All websites were categorized as institutional/reference, commercial, charitable, personal/patient support, or alternative medicine, and cross-referenced with the Health on the Net (HON) Foundation...
April 30, 2018: Urology
https://www.readbyqxmd.com/read/29719326/prospective-study-to-evaluate-the-clinical-outcome-of-intralesional-interferon-%C3%AE-2b-in-the-management-of-peyronie-s-disease
#10
Ashok Kumar Sokhal, Nilesh Kumar Jain, Ankur Jhanwar, Kawaljit Singh, Durgesh Kumar Saini
Context: Interferon (IFN)-α2b in Peyronie's disease (PD). Aims: This study aims to evaluate clinical efficacy of the IFN-α2b in both subjective and objective manner for the treatment of PD and compared with previously used intralesional verapamil in terms of cost-benefit analysis. Settings and Design: Prospective study. Materials and Methods: A prospective study conducted from January 2013 to July 2016 in the Department of Urology, Government Medical College, Kota, Rajasthan, India...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29706035/silencing-histone-deacetylase-7-alleviates-transforming-growth-factor-%C3%AE-1-induced-profibrotic-responses-in-fibroblasts-derived-from-peyronie-s-plaque
#11
Dong Hyuk Kang, Guo Nan Yin, Min Ji Choi, Kang Moon Song, Kalyan Ghatak, Nguyen Nhat Minh, Mi Hye Kwon, Do Hwan Seong, Ji Kan Ryu, Jun Kyu Suh
PURPOSE: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to study the differential gene expression of histone deacetylases (HDACs) in fibroblasts isolated from plaque tissue of Peyronie's disease (PD) or normal tunica albuginea (TA) and to examine the anti-fibrotic effect of small interfering RNA (siRNA)-mediated silencing of HDAC7 in fibroblasts derived from human PD plaque...
May 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29699756/predictive-factors-of-patients-and-their-partners-sexual-function-improvement-after-collagenase-clostridium-histolyticum-injection-for-peyronie-s-disease-results-from-a-multi-center-single-arm-study
#12
Andrea Cocci, Giorgio Ivan Russo, Andrea Salonia, Gianmartin Cito, Federica Regis, Gaia Polloni, Gianluca Giubilei, Giovanni Cacciamani, Marco Capece, Marco Falcone, Isabella Greco, Massimiliano Timpano, Andrea Minervini, Mauro Gacci, Tommaso Cai, Giulio Garaffa, Bruno Giammusso, Davide Arcaniolo, Vincenzo Mirone, Nicola Mondaini
BACKGROUND: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD). AIM: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners' bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center. METHODS: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment...
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29699751/plaque-incision-and-grafting-for-peyronie-s-disease-dead-or-alive
#13
Laurence A Levine
No abstract text is available yet for this article.
May 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29678456/inflatable-penile-prosthesis-placement-scratch-technique-and-postoperative-vacuum-therapy-as-a-combined-approach-in-the-definitive-treatment-of-patients-with-peyronie-s-disease
#14
G Antonini, E De Berardinis, F Del Giudice, G M Busetto, S Lauretti, R Fragas, B I Chung, S L Conti, D Giannarelli, I Sperduti, M S Gross, P E Perito
PURPOSE: Peyronie's disease (PD) is a devastating condition resulting in penile deformity, erectile dysfunction (ED), pain and emotional distress. This prospective two institution study evaluates a multimodal surgical and mechanical combined approach in the definitive treatment of PD and concomitant ED. MATERIALS AND METHODS: 145 selected patients underwent endocavernosal disruption of the PD plaques via the "scratch technique" followed by inflatable penile prosthesis (IPP) insertion...
April 17, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29644164/the-extra-tunical-grafting-procedure-for-peyronie-s-disease-hourglass-and-indent-deformities
#15
Amanda B Reed-Maldonado, Amjad Alwaal, Tom F Lue
Background: To describe a novel, tunica-sparing surgical technique-extra-tunical grafting (ETG)-for the treatment of penile indent and hourglass (HG) deformities and to describe patient-reported outcomes after the ETG procedure. Methods: An IRB-approved, retrospective chart review of ETG patients was performed to collect data including pre-operative deformity, operation performed, and post-operative patient-reported perception of deformity, erectile function, penile sensation, and overall satisfaction with the ETG operation...
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29623703/penile-reconstructive-surgery-in-peyronie-disease-challenges-in-restoring-normal-penis-size-shape-and-function
#16
REVIEW
Eric Chung
PURPOSE: To provide an overview of current approaches to penile reconstructive surgery in Peyronie disease (PD), and to discuss the challenges in restoring normal penile size and function. METHODS: A systematic literature search was conducted to identify the published literature relevant to PD and penile reconstructive surgery. A summary of the published guidelines from major organisations is included in this review paper. DISCUSSION: Penile plication is simple and minimally invasive, and tends to preserve potency in most patients...
March 29, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29587411/relationship-between-response-to-pde5-inhibitors-and-penile-duplex-doppler-ultrasound-in-erectile-dysfunction
#17
Ercan Ogreden, Ural Oğuz, Erhan Demirelli, Alptekin Tosun, Orhan Yalçın
The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients who did not respond to therapy were classified in to Group I ( n = 32), those who responded partially were classified into Group II ( n = 40), and complete responders were classified into Group III ( n = 76). Age, comorbidities, and vascular and penile pathologies were compared among the three groups...
March 26, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29570261/objective-measurements-of-the-penile-angulation-are-significantly-different-than-self-estimated-magnitude-among-patients-with-penile-curvature
#18
Giovanni Liguori, Andrea Salonia, Giulio Garaffa, Giovanni Chiriacò, Nicola Pavan, Giorgio Cavallini, Carlo Trombetta
INTRODUCTION: The study was aimed to assess the presence of actual differences between the objective and the perceived magnitude of a curvature between patients affected by Peyronie's disease (PD) and congenital penile curvature (CPC). MATERIALS AND METHODS: Wee analysed a cohort of 88 consecutive patients seeking medical help for either CPC or PD. All patients were invited to provide a self-made drawing of their penis in erection in order to obtain self-provided description of the deformity...
March 23, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29560030/intralesional-collagenase-clostridium-histolyticum-in-the-management-of-peyronie-s-disease-current-best-practice
#19
REVIEW
Daniel J Cwikla, Faysal A Yafi
The use of Clostridium histolyticum collagenase (CCH) has become increasingly widespread for the treatment of Peyronie's disease (PD) in recent years. Numerous trials have confirmed both its safety and efficacy in appropriately selected patients with this condition. The purpose of this review is to examine pivotal trials demonstrating the efficacy of CCH, revisit viable candidates for treatment with intralesional injection therapy, and provide a summary of injection technique and appropriate management of patients receiving this treatment at the time of therapy and in follow up...
April 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29550462/a-worldwide-survey-on-peyronie-s-disease-surgical-practice-patterns-among-surgeons
#20
Eric Chung, Run Wang, David Ralph, Laurence Levine, Gerald Brock
BACKGROUND: Despite published guidelines on Peyronie's disease (PD), there are limited data on actual surgical practice among surgeons. AIM: To evaluate the surgical practice patterns in PD among surgeons from different continents and members of various sexual medicine societies. METHODS: An anonymous survey on various pre-, intra-, and postoperative aspects of PD surgical care was distributed in printed format during International Society of Sexual Medicine meetings and as an online survey to International Society of Sexual Medicine members...
April 2018: Journal of Sexual Medicine
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