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https://www.readbyqxmd.com/read/29765532/chemopreventive-activity-of-celastrol-in-drug-resistant-human-colon-carcinoma-cell-cultures
#1
Helena Moreira, Anna Szyjka, Kazimierz Gąsiorowski
Celastrol (tripterine) a pentacyclic triterpenoid extracted from the roots of Tripterygium wilfordii Hook f., exhibits potent antioxidant and anti-inflammatory activity and also exerts important anti-cancer effects, as induction of apoptosis and lowering the level of drug resistance of several cancers. Increased level of cellular resistance to cytostatic drugs is typical for colorectal cancers, and largely determines the failure of chemotherapy for this tumor. The purpose of our research was to evaluate the chemopreventive effect of celastrol on cultures of colon cancer cells resistant to doxorubicin (LOVO/DX)...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713369/extrahepatic-cytochrome-p450s-play-an-insignificant-role-in-triptolide-induced-toxicity
#2
Yuan Wei, Dujun Wang, Meng Chen, Zhen Ouyang, Shuo Wang, Jun Gu
Background: Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. However, triptolide also causes severe side effects, which are manifested as toxicities in multiple organs. The aim of this study was to analyze the role of extrahepatic cytochrome P450 enzymes in triptolide-induced toxicity. Methods: Xh-CL mouse model with normal liver, but low extrahepatic P450 expression levels was used in this study...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29713281/the-effectiveness-and-safety-of-tripterygium-wilfordii-hook-f-extracts-in-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#3
REVIEW
Ying-Yan Zhou, Xuan Xia, Wen-Ke Peng, Qin-He Wang, Jian-Hong Peng, Yan-Lin Li, Jian-Xiong Wu, Jian-Yong Zhang, Yue Zhao, Xiu-Min Chen, Run-Yue Huang, Per-Johan Jakobsson, Ze-Huai Wen, Qing-Chun Huang
Objective: To conduct a meta-analysis of the effectiveness and safety of Tripterygium wilfordii Hook. F (TwHF) extracts for the treatment of rheumatoid arthritis (RA). Methods: A systematic literature search was conducted in PubMed, EMBASE, Cochrane, Medline, CNKI, SinoMed and WanFang Library till 12 July 2017. All included studies were analyzed with the use of the Review Manager 5.2 software according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement protocol. Results: Fourteen randomized controlled trials (RCTs) were identified...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29620171/tripterygium-glycoside-protects-against-puromycin-amino-nucleoside%C3%A2-induced-podocyte-injury-by-upregulating-autophagy
#4
Jianguang Gong, Juan Jin, Li Zhao, Yiqiao Li, Yiwen Li, Qiang He
Tripterygium glycoside (TG), an active ingredient of the widely used Chinese herb Tripterygium wilfordii Hook F, has immunosuppressive and anti‑inflammatory effects. Previous studies have indicated that TG is a potentially effective therapeutic option to treat nephrotic syndrome. The mechanism underlying the therapeutic effect of TG, including its effect on autophagy and apoptosis in podocyte injury, remains to be fully elucidated. The present study aimed to assess the protective effect of TG on podocytes via its potential role in the activation of autophagic and phosphatidylinositol 3‑kinase (PI3K) pathways...
March 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29615906/mechanisms-of-triptolide-induced-hepatotoxicity-and-protective-effect-of-combined-use-of-isoliquiritigenin-possible-roles-of-nrf2-and-hepatic-transporters
#5
Zhenyan Hou, Lei Chen, Pingfei Fang, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Huande Li, Bikui Zhang, Miao Yan
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclear transcription factor E2-related factor 2 (Nrf2) and hepatic transporters in TP-induced hepatotoxicity and the reversal protective effect of ISL. TP treatment caused both cytotoxicity in L02 hepatocytes and acute liver injury in mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29576791/a-systematic-review-about-the-efficacy-and-safety-of-tripterygium-wilfordii-hook-f-preparations-used-for-the-management-of-rheumatoid-arthritis
#6
REVIEW
Jing Wang, Na Chen, Liang Fang, Zhe Feng, Guochun Li, Attilio Mucelli, Xu Zhang, Xueping Zhou
Tripterygium wilfordii Hook.f. (TWHF) is a traditional Chinese herb long used for rheumatoid arthritis (RA) treatment, in modern times, often in the form of various Tripterygium wilfordii Hook.f. preparations (TWPs). This systematic review and meta-analysis focuses on analyzing the clinical efficacy and safety of TWPs in the treatment of RA. Databases were searched to collect the randomized controlled trials (RCTs) on TWPs treating RA published on or before April 10, 2017. Data from 11 studies were included in this meta-analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29507594/traditional-chinese-medicine-for-refractory-nephrotic-syndrome-strategies-and-promising-treatments
#7
REVIEW
Xiao-Qin Wang, Lan Wang, Yuan-Chao Tu, Yuan Clare Zhang
Refractory nephrotic syndrome (RNS) is an immune-related kidney disease with poor clinical outcomes. Standard treatments include corticosteroids as the initial therapy and other immunosuppressants as second-line options. A substantial proportion of patients with RNS are resistant to or dependent on immunosuppressive drugs and often experience unremitting edema and proteinuria, cycles of remission and relapse, and/or serious adverse events due to long-term immunosuppression. Traditional Chinese medicine has a long history of treating complicated kidney diseases and holds great potential for providing effective treatments for RNS...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29491837/a-mechanistic-overview-of-triptolide-and-celastrol-natural-products-from-tripterygium-wilfordii-hook-f
#8
REVIEW
Shao-Ru Chen, Yan Dai, Jing Zhao, Ligen Lin, Yitao Wang, Ying Wang
Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29481812/food-poisoning-associated-with-ingestion-of-wild-wasp-broods-in-the-upstream-region-of-the-lancang-river-valley-yunnan-province-china
#9
Li Jiang, Tian Huang
INTRODUCTION: Food poisoning due to wild wasp broods ingestion has long been noted in the upstream region of the Lancang river valley, Yunnan province, China. This study describes the epidemiological and clinical features of the poisoning and possible causes. METHODS: Surveillance data collected between 2008 and 2016 were analyzed to produce demographic data on patients, information on clinical presentations, wasp species identification, and estimations of possible risk factors for symptomatic cases...
April 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29426375/triptolide-inhibits-proliferation-and-migration-of-human-neuroblastoma-sh-sy5y-cells-by-up-regulating-microrna-181a
#10
Jian Jiang, Xuewen Song, Jing Yang, Ke Lei, Yongan Ni, Fei Zhou, Lirong Sun
Neuroblastoma is the primary cause of cancer-related death for children one to five years of age. New therapeutic strategies and medicines are urgently needed. This study aimed to investigate the effects of triptolide (TPL), the major active component purified from Tripterygium wilfordii Hook F, on neuroblastoma SH-SY5Y cell proliferation, migration and apoptosis, as well as underlying potential mechanisms. We found that TPL inhibited SH-SY5Y cell viability, proliferation and migration but induced cell apoptosis...
February 9, 2018: Oncology Research
https://www.readbyqxmd.com/read/29407771/triptolide-induces-mitochondria-mediated-apoptosis-of-burkitt-s-lymphoma-cell-via-deacetylation-of-gsk-3%C3%AE-by-increased-sirt3-expression
#11
Jiamin Kong, Li Wang, Lu Ren, Yujing Yan, Yisen Cheng, Zhiying Huang, Feihai Shen
Burkitt's lymphoma (BL) is a highly aggressive B-cell non-Hodgkin lymphoma with rapid growth and dissemination propensity. Triptolide (TP), an active component extracted from Chinese herb Tripterygium wilfordii Hook f., has broad-spectrum anti-tumor activities. This study aimed to explore the in vitro and in vivo anti-cancer effects of TP on BL and the potential molecular mechanisms. In this study, the in vitro anti-tumor activity of TP was determined by CCK-8 and flow cytometry assays in Raji, NAMALWA and Daudi cells...
March 1, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29407366/low-but-not-high-dose-triptolide-controls-neuroinflammation-and-improves-behavioral-deficits-in-toxic-model-of-multiple-sclerosis-by-dampening-of-nf-%C3%AE%C2%BAb-activation-and-acceleration-of-intrinsic-myelin-repair
#12
Nima Sanadgol, Fereshteh Golab, Ali Mostafaie, Mehdi Mehdizadeh, Roghayeh Khalseh, Morteza Mahmoudi, Mohammad Abdollahi, Gelareh Vakilzadeh, Ghorban Taghizadeh, Mohammad Sharifzadeh
Cuprizone (Cup) is a copper chelating agent frequently used to study factors that affect oligodendrocytes (OLGs) death and acute demyelination. Triptolide (TP), a nuclear factor-kappaB (NF-κB) blocker, is a major bioactive component of Tripterygium wilfordii Hook f. (TWHf) with various therapeutic activities. In this study, we examined the effects of TP on neuroglia activation, inflammation, apoptosis, demyelination, and behavioral deficits in the Cup-induced toxic model of multiple sclerosis (MS). C57BL/6 J mice were fed with chow containing 0...
March 1, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29382023/case-report-remarkable-remission-of-sapho-syndrome-in-response-to-tripterygium-wilfordii-hook-f-treatment
#13
Chen Li, Xiaochuan Sun, Yihan Cao, Wenrui Xu, Wen Zhang, Zhenhua Dong
RATIONALE: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is an autoinflammatory disease with no standardized treatment. Tripterygium wilfordii hook f (TwHF) is a Chinese herb with immunosuppressive effects and has been used to treat some chronic inflammatory diseases. However, it has not been reported as a therapeutic option in SAPHO syndrome. Here we present the first report in which a remarkable remission of SAPHO syndrome was achieved in response to TwHF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29373547/the-effect-of-triptolide-in-rheumatoid-arthritis-from-basic-research-towards-clinical-translation
#14
REVIEW
Danping Fan, Qingqing Guo, Jiawen Shen, Kang Zheng, Cheng Lu, Ge Zhang, Aiping Lu, Xiaojuan He
Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed...
January 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29283173/cyp3a4-inducer-and-inhibitor-strongly-affect-the-pharmacokinetics-of-triptolide-and-its-derivative-in-rats
#15
Ye Xu, Yi-Fan Zhang, Xiao-Yan Chen, Da-Fang Zhong
Triptolide is the most active ingredient of Tripterygium wilfordii Hook F, which is used to treat rheumatoid arthritis. (5R)-5-Hydroxytriptolide is a hydroxylation derivative of triptolide with a reduced toxicity. To investigate the metabolic enzymes of the two compounds and the drug-drug interactions with enzyme inducers or inhibitors, a series of in vitro and in vivo experiments were conducted. In vitro studies using recombinant human cytochrome P450 enzyme demonstrated that cytochrome P450 3A4 (CYP3A4) was predominant in the metabolism of triptolide and (5R)-5-hydroxytriptolide, accounting for 94...
December 28, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29277608/triptolide-induced-hepatotoxicity-can-be-alleviated-when-combined-with-panax-notoginseng-saponins-and-catapol
#16
Lingling Zhou, Cong Zhou, Zhe Feng, Zhangpu Liu, Huaxu Zhu, Xueping Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: The hepatotoxicity of Tripterygium wilfordii Hook. f. (TW), due to the presence of triptolide (TP), limits its therapeutic potential. Based on the traditional Chinese medicine theory, the theory of "Yi lei xiang zhi" was proposed that Chinese herbs with different efficacy can restrict each other to achieve the least adverse reactions. AIM OF THE STUDY: To observe the effects of Catapol (CAT) and Panax notoginseng saponins (PNS), active ingredients in Rehmannia glutinosa (RG) and Panax notoginseng (PN) respectively, on reducing TP-induced hepatotoxicity, and further to explore the mechanisms...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29193402/efficacy-and-safety-of-tripterygium-wilfordii-hook-f-for-ckd-in-mainland-china-a-systematic-review-and-meta-analysis
#17
Duo Wang, Xiao-Han Zhao, Yi Cui, Tian-Tian Zhang, Fang Wang, Yong-Hong Hu
Tripterygium wilfordii Hook F (TwHF) is a promising Chinese traditional medicine used to significantly reduce proteinuria and improve renal function. However, its efficacy and safety in treatment of chronic kidney disease need to be further explored in order to promote its application in clinics. This review compared the efficacy and safety of TwHF with the placebo, conventional Western medicine and other immunosuppressive medicine in a range of kidney disorders. One hundred three randomized controlled trials were included...
March 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29186241/clinical-features-of-von-zumbusch-type-of-generalized-pustular-psoriasis-in-children-a-retrospective-study-of-26-patients-in-southwestern-china
#18
Qian Wang, Wei Liu, Lixia Zhang
BACKGROUND: Von Zumbusch type of generalized pustular psoriasis is a rare variant of psoriasis in children. It can occur in patients with or without psoriasis vulgaris. OBJECTIVE: The aim of the study was to discuss the precipitating factors, clinical manifestations, laboratory data and therapy of von Zumbusch type of generalized pustular psoriasis in children from southwestern China and to improve the diagnosis and treatment level. METHODS: A retrospective analysis was conducted for inpatients aged 14 years old or less with von Zumbusch type of generalized pustular psoriasis in our department from 2005 to 2014...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29072681/demethylzeylasteral-inhibits-cell-proliferation-and-induces-apoptosis-through-suppressing-mcl1-in-melanoma-cells
#19
Yuzu Zhao, Jiang He, Jun Li, Xingzhi Peng, Xianxing Wang, Zhen Dong, Erhu Zhao, Yaling Liu, Zonghui Wu, Hongjuan Cui
Demethylzeylasteral is one of the extracts of Tripterygium wilfordii Hook F, which plays important roles in multiple biological processes such as inflammation inhibition, as well as immunosuppression. However, anti-cancer function and the underlying mechanisms of demethylzeylasteral in melanoma cells remain unclear. In this study, we demonstrate that demethylzeylasteral has an anti-tumor property in melanoma cells. Demethylzeylasteral not only inhibits cell proliferation through cell cycle arrest at S phase, but also induces cell apoptosis in melanoma cells...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28984147/celastrol-ameliorates-acetaminophen-induced-oxidative-stress-and-cytotoxicity-in-hepg2-cells
#20
A T Jannuzzi, M Kara, B Alpertunga
Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. However, hepatotoxicity caused by APAP overdose is the most frequent cause of acute liver failure worldwide and oxidative stress involved in the pathogenesis of APAP hepatotoxicity. Celastrol is a natural triterpenoid derived from Tripterygium wilfordii Hook F. that exhibits antioxidant, anti-inflammatory, and antitumor activities. In this study, we aimed to investigate the potential ameliorative effects of celastrol against APAP-induced cytotoxicity and oxidative stress...
January 1, 2017: Human & Experimental Toxicology
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