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https://www.readbyqxmd.com/read/27908660/targeting-of-multiple-senescence-promoting-genes-and-signaling-pathways-by-triptonide-induces-complete-senescence-of-acute-myeloid-leukemia-cells
#1
Yanyan Pan, Mei Meng, Nana Zheng, Zhifei Cao, Ping Yang, Xiaodong Xi, Quansheng Zhou
Leukemia cells aberrantly overexpress senescence-suppression telomerase reverse transcriptase (TERT) and down-regulate key senescence-promoting genes to escape complete senescence, resulting in immortalization and malignant progression. Accordingly, induction of complete senescence is a sensible strategy for anti-leukemia therapy. However, effective senescence-based anti-leukemia drugs with low toxicity are currently lacking. In this study, we found that triptonide (chemical name diterpene triepoxide), a small molecule derived from the herb Tripterygium wilfordii Hook, strongly induced complete senescence in cultured acute myeloid leukemia (AML) cell lines, and potently inhibited growth and colony formation of U937 and HL-60 AML cell line with IC50 values of 7...
November 28, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27900040/triptolide-exerts-pro-apoptotic-and-cell-cycle-arrest-activity-on-drug-resistant-human-lung-cancer-a549-taxol-cells-via-modulation-of-mapk-and-pi3k-akt-signaling-pathways
#2
Chen Qiong Xie, Ping Zhou, Jian Zuo, Xiang Li, Yong Chen, Jian Wei Chen
Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (including A549/Taxol, MCF-7/ADR and Bel7402/5-Fu). The present study was designed to investigate its anti-proliferative activity on A549/Taxol cells, and explore the underlying mechanism of action...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27877128/safety-profiles-of-tripterygium-wilfordii-hook-f-a-systematic-review-and-meta-analysis
#3
Chi Zhang, Ping-Ping Sun, Hong-Tao Guo, Yan Liu, Jian Li, Xiao-Juan He, Ai-Ping Lu
Objective:Tripterygium wilfordii Hook F (TwHF) is a widely used and effective treatment for inflammatory diseases. There have been concerns about its toxicity but no adequate synthesis of the evidence for adverse events (AEs). We aimed to undertake a clinically informative, systematic safety profile of TwHF. Methods: We undertook a systematic review and meta-analysis of experimental studies and observational studies. We searched electronic databases and conference abstracts. Safety outcomes were rates of common AEs...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27875907/chemical-constituents-from-the-roots-of-tripterygium-wilfordii-and-their-cytotoxic-activity
#4
Chang Gao, Li-Li Lou, Di Wang, Yan Zhang, Xiao-Xiao Huang, Shao-Jiang Song
In our ongoing search for bioactive constituents, a new sesquiterpene polyol ester, named triptersinine U (1), together with five known triterpenes (2-6) and seven sesquiterpene pyridine alkaloids (7-13), were isolated from the roots of Tripterygium wilfordii Hook. f. Their chemical structures were elucidated using extensive spectroscopic analyses, including 1D and 2D NMR, and HRESIMS, as well as comparison with previously reported data. Cytotoxic activities of all compounds 1-13 were evaluated against six human tumor cell lines (HepG2, Hep3B, Bcap37, U251, MCF-7 and A549) using the MTT in vitro assay...
November 22, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27857756/effects-of-triptolide-on-hippocampal-microglial-cells-and-astrocytes-in-the-app-ps1-double-transgenic-mouse-model-of-alzheimer-s-disease
#5
Jian-Ming Li, Yan Zhang, Liang Tang, Yong-Heng Chen, Qian Gao, Mei-Hua Bao, Ju Xiang, De-Liang Lei
The principal pathology of Alzheimer's disease includes neuronal extracellular deposition of amyloid-beta peptides and formation of senile plaques, which in turn induce neuroinflammation in the brain. Triptolide, a natural extract from the vine-like herb Tripterygium wilfordii Hook F, has potent anti-inflammatory and immunosuppressive efficacy. Therefore, we determined if triptolide can inhibit activation and proliferation of microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27847199/triptolide-inhibits-the-migration-and-invasion-of-human-prostate-cancer-cells-via-caveolin-1-cd147-mmps-pathway
#6
Shiqi Yuan, Liping Wang, Xixi Chen, Bo Fan, Qingmin Yuan, Han Zhang, Deyong Yang, Shujing Wang
Prostate cancer (PCa) is the second most common type of carcinoma and the 5th leading cause of cancer-related death in males. Triptolide, is a main and effective component of Tripterygium wilfordii Hook F, which exerts an broad-spectrum anti-malignant tumor function. However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27819370/competitive-profiling-of-celastrol-targets-in-human-cervical-cancer-hela-cells-via-quantitative-chemical-proteomics
#7
Yiqing Zhou, Weichao Li, Mingli Wang, Xixi Zhang, Haibing Zhang, Xiaofeng Tong, Youli Xiao
Celastrol, isolated from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f. (Thunder God's Vine), has been used to treat cancer, chronic inflammatory, autoimmune and other human diseases. However, to date, the protein targets and the mechanism of action of celastrol have remained elusive. In this study, we find that celastrol can react with protein thiols in a unique covalent and reversible manner, while protein denaturing disrupts the interaction. Through a competitive chemoproteomics approach utilizing a cysteine-targeting activity-based probe, we report the proteome-wide quantitative profiling of cellular targets of celastrol in human cervical cancer HeLa cells...
November 7, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27816728/triptolide-inhibits-the-migration-and-invasion-of-rheumatoid-fibroblast-like-synoviocytes-by-blocking-the-activation-of-the-jnk-mapk-pathway
#8
Yanlong Yang, Yujin Ye, Qian Qiu, Youjun Xiao, Mingcheng Huang, Maohua Shi, Liuqin Liang, Xiuyan Yang, Hanshi Xu
Triptolide, a primary active ingredient extracted from a traditional Chinese herb, Tripterygium wilfordii Hook F, has been demonstrated to have a positive therapeutic effect on patients with rheumatoid arthritis (RA); however, its mechanism of action against RA is not well established. Therefore, in the present study, we observed the effect of triptolide on the aggressive behavior of RA fibroblast-like synoviocytes (RA FLSs), and we explored its underlying signal mechanisms. We found that triptolide treatment significantly reduced the migratory and invasive capacities of RA FLSs in vitro...
October 27, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27649810/differential-expressed-analysis-of-tripterygium-wilfordii-unigenes-involved-in-terpenoid-backbone-biosynthesis
#9
Jing Zhang, Yan-Bo Huo, Yan Liu, Jun-Tao Feng, Zhi-Qing Ma, Chuan-Shu Zhu, Xing Zhang
Tripterygium wilfordii Hook. f. is the traditional medicinal plants in China. Triptolide, wilforgine, and wilforine are the bioactive compounds in T. wilfordii. In this study, the contents of three metabolites and transcription levels of 21 genes involved in three metabolites biosynthesis in T. wilfordii were examined using high-performance liquid chromatography and reverse transcription PCR after application of methyl jasmonate (MeJA) on hairy roots in time course experiment (3-24 h). The results indicated that application of MeJA inhibited triptolide accumulation and promoted wilforgine and wilforine metabolites biosynthesis...
September 21, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27601081/identification-of-species-in-tripterygium-celastraceae-based-on-dna-barcoding
#10
Xiaomei Zhang, Na Li, Yuanyuan Yao, Xuming Liang, Xianyou Qu, Xiang Liu, Yingjie Zhu, Dajian Yang, Wei Sun
Species of genus Tripterygium (Celastraceae) have attracted much attention owing to their excellent effect on treating autoimmune and inflammatory diseases. However, due to high market demand causing overexploitation, natural populations of genus Tripterygium have rapidly declined. Tripterygium medicinal materials are mainly collected from the wild, making the quality of medicinal materials unstable. Additionally, identification of herbal materials from Tripterygium species and their adulterants is difficult based on morphological characters...
September 6, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27596363/triptonide-effectively-inhibits-wnt-%C3%AE-catenin-signaling-via-c-terminal-transactivation-domain-of-%C3%AE-catenin
#11
Jessica Chinison, Jose S Aguilar, Alan Avalos, Ying Huang, Zhijun Wang, D Joshua Cameron, Jijun Hao
Abnormal activation of canonical Wnt/β-catenin signaling is implicated in many diseases including cancer. As a result, therapeutic agents that disrupt this signaling pathway have been highly sought after. Triptonide is a key bioactive small molecule identified in a traditional Chinese medicine named Tripterygium wilfordii Hook F., and it has a broad spectrum of biological functions. Here we show that triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27554044/triptolide-disrupts-the-actin-based-sertoli-germ-cells-adherens-junctions-by-inhibiting-rho-gtpases-expression
#12
Xiang Wang, Fang Zhao, Zhong-Ming Lv, Wei-Qin Shi, Lu-Yong Zhang, Ming Yan
Triptolide (TP), derived from the medicinal plant Triterygium wilfordii Hook. f. (TWHF), is a diterpene triepoxide with variety biological and pharmacological activities. However, TP has been restricted in clinical application due to its narrow therapeutic window especially in reproductive system. During spermatogenesis, Sertoli cell cytoskeleton plays an essential role in facilitating germ cell movement and cell-cell actin-based adherens junctions (AJ). At Sertoli cell-spermatid interface, the anchoring device is a kind of AJ, known as ectoplasmic specializations (ES)...
November 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27431437/multi-glycoside-of-tripterygium-wilfordii-hook-%C3%A2-f-ameliorates-imiquimod-induced-skin-lesions-through-a-stat3-dependent-mechanism-involving-the-inhibition-of-th17-mediated-inflammatory-responses
#13
Jingxia Zhao, Tingting Di, Yan Wang, Xin Liu, Daiying Liang, Guangzhong Zhang, Ping Li
Multi-glycoside of Tripterygium wilfordii Hook. f.(GTW) possesses anti-inflammatory and immunosuppressive properties, and has been used as a traditional treatment for psoriasis for many years, although the underlying immunological mechanisms remain poorly understood. The T helper (Th)17 cell response is considered to play a major role in the pathogenesis of psoriasis. Th17 cells are implicated in the mechanism of pathogenesis of imiquimod (IMQ)‑induced skin inflammation. Using a mouse model, we demonstrated that GTW protected mice from developing psoriasis-like lesions induced by topical IMQ administration...
September 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27411429/tripterygium-wilfordii-hook-f-versus-conventional-synthetic-disease-modifying-anti-rheumatic-drugs-as-monotherapy-for-rheumatoid-arthritis-a-systematic-review-and-network-meta-analysis
#14
Hai-Long Wang, Quan Jiang, Xing-Hua Feng, Hua-Dong Zhang, Lin Ge, Cheng-Gui Luo, Xun Gong, Bo Li
BACKGROUND: Tripterygium wilfordii Hook F (TwHF), a medicinal plant that has been widely used in Chinese traditional medicine, is proven effective for treating rheumatoid arthritis (RA), but its clinical efficacy and safety remain largely undefined in comparison with conventional synthetic disease modifying anti-rheumatic drugs (DMARDs). METHODS: PubMed, Embase, Cochrane Library, CNKI, VIP, CBM, and WanFang Databases. Endpoints were ACR 20, 50, and 70, and the number of withdrawals due to adverse events...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27398312/mutations-y493g-and-k546d-in-human-hsp90-disrupt-binding-of-celastrol-and-reduce-interaction-with-cdc37
#15
Bin Peng, Yi-Jun Gu, Ying Wang, Fan-Fan Cao, Xue Zhang, Deng-Hai Zhang, Jian Hou
Celastrol, a natural compound derived from the Chinese herb Tripterygium wilfordii Hook F, has been proven to inhibit heat shock protein 90 (HSP90) activity and has attracted much attention because of its promising effects in cancer treatment and in ameliorating degenerative neuron diseases. However, the HSP90 structure involved in celastrol interaction is not known. Here, we report a novel celastrol-binding pocket in the HSP90 dimer, predicted by molecular docking. Mutation of the two key binding pocket amino acids (Lys546 and Tyr493) disrupted the binding of celastrol to HSP90 dimers, as detected by isothermal titration calorimetry (ITC)...
July 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27351576/tripterygium-wilfordii-hook-f-is-efficacious-in-the-treatment-of-henoch-sch%C3%A3-nlein-purpura-nephritis-in-children
#16
Shu-Jiong Mao, Xian-Mei Huang
No abstract text is available yet for this article.
August 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27307742/neuroprotection-by-triptolide-against-cerebral-ischemia-reperfusion-injury-through-the-inhibition-of-nf-%C3%AE%C2%BAb-puma-signal-in-rats
#17
Bin Zhang, Cunfeng Song, Bo Feng, Weibing Fan
Triptolide, an active compound extracted from the Chinese herb thunder god vine (Tripterygium wilfordii Hook F.), has potent antitumor activity. Recently, triptolide was found to have protective effects against acute cerebral ischemia/reperfusion (I/R) injury through inhibition of cell apoptosis. However, the regulatory mechanism of the effect remains unclear. We hypothesize that the regulatory mechanisms of triptolide are mediated by nuclear factor κB (NF-κB) and p53-upregulated-modulator-of-apoptosis signal inhibition...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27259309/evaluation-of-immunosuppressive-activity-of-demethylzeylasteral-in-a-beagle-dog-kidney-transplantation-model
#18
Huimin An, Yu Zhu, Wenping Xu, Yujun Liu, Jianping Zhang, Zongming Lin
Several monomers isolated from Tripterygium wilfordii Hook f. (Celastraceae) have attracted worldwide interest. In this study, we established a simple and reliable kidney transplantation model in beagle dog to evaluate the immunosuppressive activity of demethylzeylasteral (T-96), an immunosuppressive monomer isolated from the root xylem of T. wilfordii. Recipient and donor male beagle dogs were obtained from two different breeders to ensure MHC mismatching. All dogs were randomly divided into six groups following kidney transplantation, and different doses of T-96 or cyclosporine A (CsA) were administered to each group during 14 days of observation...
December 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27224044/the-pharmacological-effects-and-mechanism-of-tripterygium-wilfordii-hook-f-in-central-nervous-system-autoimmunity
#19
Qing Wang, Jian Meng, Aiguo Dong, Jie-Zhong Yu, Guang-Xian Zhang, Cun-Gen Ma
OBJECTIVE: Extracts of the Chinese herb Tripterygium wilfordii Hook F (TwHF) have potent anti-inflammatory functions and are widely used to treat rheumatoid arthritis and Crohn's disease. They have also been considered as potential drugs in the treatment of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. METHODS: A systematic search of MEDLINE, EMBASE, PubMed, and the China National Knowledge Infrastructure (CNKI) was performed...
July 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27222828/immunosuppressive-anti-inflammatory-and-anti-cancer-properties-of-triptolide-a-mini-review
#20
REVIEW
Samira Ziaei, Reginald Halaby
OBJECTIVE: Triptolide, the active component of Tripterygium wilfordii Hook F has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional Chinese medicine. However, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. In this review, we discuss the autoimmune disorders and inflammatory conditions that are currently treated with triptolide. Triptolide also possesses anti-tumorigenic effects...
March 2016: Avicenna Journal of Phytomedicine
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