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https://www.readbyqxmd.com/read/28938525/toxic-effects-of-tripterygium-wilfordii-hook-f-on-the-reproductive-system-of-adolescent-male-rats
#1
Xiaoping Jing, Weiwei Cheng, Sheng Guo, Ya Zou, Ting Zhang, Li He
Tripterygium wilfordii Hook F. (TWHF) is a compound extracted from Lei Gong Teng (Thunder God Vine) that has been used to treat a variety of immune-related diseases in clinical practice, particularly in pediatrics. Nevertheless, clinical data indicated that glycosides from Tripterygium wilfordii Hook F (GTW) are toxic to the male reproductive system, but the mechanism is unknown. Here, the administration of a high dose of GTW for 4 weeks and a low dose for 12 weeks can reduce the body weights and testes weights in adolescent male rats...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28901387/triptolide-blocks-the-stat3-signaling-pathway-through-induction-of-protein-tyrosine-phosphatase-shp-1-in-multiple-myeloma-cells
#2
Ji-Hun Kim, Byoungduck Park
Triptolide, an active component extracted from the medicinal plant Tripterygium wilfordii Hook F., has been used to treat various diseases, including lupus, cancer, rheumatoid arthritis and nephritic syndrome. The present study investigated the effects of triptolide on multiple myeloma using western blotting and an electrophoretic mobility shift assay. Triptolide was found to suppress the inducible and constitutive activation of signal transducer and activator of transcription 3 (STAT3), which is closely associated with inflammation and tumorigenesis...
September 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28895652/quantitative-proteomics-and-targeted-fatty-acids-analysis-reveal-the-damage-of-triptolide-in-liver-and-kidney
#3
Menglin Li, Ting Hu, Cai Tie, Liang Qu, Hao Zheng, Jinlan Zhang
Triptolide (TP), the major active component in Tripterygium wilfordii Hook. f., is widely used for the treatment of rheumatoid arthritis and autoimmune disease. However, organ toxicity, especially hepatotoxicity and nephrotoxicity, limits its clinical application. To fully understand the mechanism underlying TP toxicity, iTRAQ-based 2D-LC-MS/MS proteomics was used to detect differentially expressed proteins in the livers and kidneys of mice administered the LD50 dose of TP. Functional annotation revealed that multiple pathways are involved in TP toxicity, including acute-phase response signaling, the antigen presentation pathway, FXR/RXR activation, LPS/IL-1-mediated inhibition of RXR function and EIF2 signaling...
September 12, 2017: Proteomics
https://www.readbyqxmd.com/read/28892788/triptolide-suppresses-growth-and-hormone-secretion-in-murine-pituitary-corticotroph-tumor-cells-via-nf-kappab-signaling-pathway
#4
Ran Li, Zhuo Zhang, Junwen Wang, Yiming Huang, Wei Sun, Ruifan Xie, Feng Hu, Ting Lei
Triptolide is a principal diterpene triepoxide from the Chinese medical plant Tripterygium wilfordii Hook. f., whose extracts have been utilized in dealing with diverse diseases in traditional Chinese medicine for centuries. Recently, the antitumor effect of triptolide has been found in several pre-clinical neoplasm models, but its effect on pituitary corticotroph adenomas has not been investigated so far. In this study, we are aiming to figure out the antitumor effect of triptolide and address the underlying molecular mechanism in AtT20 murine corticotroph cell line...
September 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28890697/effect-of-the-natural-product-triptolide-on-pancreatic-cancer-a-systematic-review-of-preclinical-studies
#5
Chi Zhang, Xiao-Juan He, Li Li, Cheng Lu, Ai-Ping Lu
Objective: Triptolide (TL), a natural product isolated from Tripterygium wilfordii Hook F (TwHF), shows potent anticancer effects in vitro and in vivo. We aimed to summary the biochemical mechanisms through which TL has been shown to induce apoptosis, autophagy and inhibit angiogenesis in pancreatic cancer (PC). Methods: We undertook a systematic review of preclinical evidence. We searched electronic databases. The potential mechanisms and the underlying signaling pathways have been accumulated as well. Results: We screened 116 abstracts for eligibility and included 17 preclinical studies in the analysis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28870177/will-chinese-external-therapy-with-compound-tripterygium-wilfordii-hook-f-gel-safely-control-disease-activity-in-patients-with-rheumatoid-arthritis-design-of-a-double-blinded-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Quan Jiang, Xiao-Po Tang, Xian-Chun Chen, Hong Xiao, Ping Liu, Juan Jiao
BACKGROUND: Chinese external therapy (CET) is a topical application with mainly Chinese herb medicine therapy with thousands of years of historical implications and is a clinical routine that is commonly used for relieving joint-related symptoms in patients with arthritis in Chinese hospitals. However, there is a paucity of modern medical evidence to support its effectiveness and safety. Thus, we propose to implement a randomized, double-blinded, placebo-controlled clinical trial in patients with rheumatoid arthritis (RA) using, as the experimental intervention, topical application of a hospital-compounded gel preparation of Tripterygium wilfordii Hook F (TwHF)...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28867717/effects-of-tripterygium-wilfordii-hook-f-induction-therapy-to-iga-nephropathy-patients-with-heavy-proteinuria
#7
Zhen Wang, Chao Yu, Li-Na Zhou, Xin Chen
Although some new drugs have been developed, Tripterygium wilfordii Hook F.(TWHF)has the merits of relatively lower price and fewer side effects. Unfortunately, the efficacy and safety of the TWHF (especially dosage 120mg/day) in the IgA nephropathy(IgAN) are still lacking. A cohort study including 49 IgAN patients with heavy proteinuria who received induction therapy was undertaken. Patients were divided into three groups: Prednisone (PRE), conventional-dose TWHF (CTW) and double-dose TWHF (DTW). The clinical features, laboratory data, histological manifestations and outcomes of the groups were compared...
September 1, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28864208/a-new-mechanism-of-inhibition-of-il-1%C3%AE-secretion-by-celastrol-through-the-nlrp3-inflammasome-pathway
#8
Wenyu Xin, Qiaoyun Wang, Dan Zhang, Chaoyun Wang
The NLRP3 (NOD-like receptor protein 3) inflammasome is a caspase-1-containing multiprotein complex that controls the release of IL-1β and has been associated with the development of inflammatory diseases. Celastrol, a pharmacologically active ingredient extracted from Tripterygium wilfordii Hook, has anti-inflammatory activities based on its inhibition of IL-1β secretion. The purpose of the present study was to investigate the possible modulation of NLRP3 inflammasome-mediated IL-1β and IL-18 release from macrophages by celastrol...
August 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28755953/kidney-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-3-of-5-series
#9
REVIEW
Amy Christine Brown
BACKGROUND: No tabular summary of potentially life-threatening, kidney-toxic dietary supplements (DS; includes herbs) based on PubMed case reports is currently available online and continually updated to forewarn United States consumers, clinicians, and companies manufacturing DS. The purpose of this review was to create an online research summary table of kidney toxicity case reports related to DS. METHODS: Documented PubMed case reports (1966 to May 2016, and cross-referencing) of DS appearing to contribute to kidney toxicity were listed in "DS Toxic Tables...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28733871/a-mdr-transporter-contributes-to-the-different-extracellular-production-of-sesquiterpene-pyridine-alkaloids-between-adventitious-root-and-hairy-root-liquid-cultures-of-tripterygium-wilfordii-hook-f
#10
Guo-Peng Miao, Juan Han, Ji-Feng Zhang, Chuan-Shu Zhu, Xing Zhang
TwMDR1 transports sesquiterpene pyridine alkaloids, wilforine and wilforgine, into the hairy roots of T. wilfordii Hook.f. resulting in low secretion ratio of alkaloids. Hairy roots (HRs) exhibit high growth rate and biochemical and genetic stability. However, varying secondary metabolites in HR liquid cultures mainly remain in root tissues, and this condition may affect cell growth and cause inconvenience in downstream extraction. Studies pay less attention to adventitious root (AR) liquid cultures though release ratio of some metabolites in AR liquid cultures is significantly higher than that of HR...
July 21, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28731135/multi-glycoside-of-tripterygium-wilfordii-hook-%C3%A2-f-attenuates-glomerulosclerosis-in-a-rat-model-of-diabetic-nephropathy-by-exerting-anti-microinflammatory-effects-without-affecting-hyperglycemia
#11
Wei Wu, Jing-Jing Yang, Hai-Ming Yang, Meng-Meng Huang, Qi-Jun Fang, Ge Shi, Zhi-Min Mao, Wen-Bei Han, Shan-Mei Shen, Yi-Gang Wan
Multi-glycoside of Tripterygium wilfordii Hook. f. (GTW) has been proven to be clinically effective in relieving microinflammation in patients with early diabetic nephropathy (DN). However, the therapeutic mechanisms involved in vivo remain unclear. In the process of early DN, microinflammation and activation of p38 mitogen‑activated protein kinase (MAPK) and canonical nuclear factor (NF)-κB signaling pathways are the important mechanisms by which hyperglycemia contributes to glomerulosclerosis (GS)...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28672939/triptolide-suppresses-ultraviolet-b-enhanced-sebum-production-by-inhibiting-the-biosynthesis-of-triacylglycerol-in-hamster-sebaceous-glands-in-vivo-and-in-vitro
#12
Takashi Sato, Noriko Akimoto, Aiko Takahashi, Akira Ito
Ultraviolet B (UVB) irradiation causes alterations in cutaneous barrier function, including excessive production of sebum in sebaceous glands, which is associated with the aggravation of acne. This study aimed to evaluate the inhibitory effects of triptolide, a diterpenoid triepoxide from Tripterygium wilfordii Hook F, on sebocytic lipogenesis in UVB-irradiated hamster skin in vivo and in vitro. Topical application of triptolide decreased the UVB-enhanced sebum accumulation in the sebaceous glands of hamster skin...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28666825/triptonide-acts-as-a-novel-potent-anti-lymphoma-agent-with-low-toxicity-mainly-through-inhibition-of-proto-oncogene-lyn-transcription-and-suppression-of-lyn-signal-pathway
#13
Ping Yang, Fulu Dong, Quansheng Zhou
Lyn is a proto-oncogene overexpressed and constitutively activated in lymphoma, and plays an important role in lymphoma initiation and malignant progression. Hence, the oncogenic Lyn has recently been targeted for novel anti-lymphoma drug discovery; however, the effective Lyn-targeted drug for lymphoma treatment with low toxicity is absent in the clinical setting. The goal of this study is to explore powerful and low toxic Lyn-targeted anti-lymphoma agent. Here we show that triptonide, a small molecule purified from the herb Tripterygium wilfordii Hook F, potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5...
August 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28638477/triptolide-inhibits-the-ar-signaling-pathway-to-suppress-the-proliferation-of-enzalutamide-resistant-prostate-cancer-cells
#14
Yangyang Han, Weiwei Huang, Jiakuan Liu, Dandan Liu, Yangyan Cui, Ruimin Huang, Jun Yan, Ming Lei
Enzalutamide is a second-generation androgen receptor (AR) antagonist for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Unfortunately, AR dysfunction means that resistance to enzalutamide will eventually develop. Thus, novel agents are urgently needed to treat this devastating disease. Triptolide (TPL), a key active compound extracted from the Chinese herb Thunder God Vine (Tripterygium wilfordii Hook F.), possesses anti-cancer activity in human prostate cancer cells. However, the effects of TPL against CRPC cells and the underlying mechanism of any such effect are unknown...
2017: Theranostics
https://www.readbyqxmd.com/read/28599756/tripterygium-wilfordii-inhibiting-angiogenesis-for-rheumatoid-arthritis-treatment
#15
REVIEW
Weisan Zhang, Fengtan Li, Wenyuan Gao
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a serious pre-vascular inflammatory phase, followed by significant increase in vessel growth. Inhibition of angiogenesis is a novel therapeutic strategy against RA. The Chinese herbal remedy Tripterygium wilfordii, Hook. f. (TwHf) has been reported to be therapeutically efficacious in the treatment of RA. Recent studies have revealed that treatment with TwHf extracts inhibit angiogenesis of RA, thereby elaborately attenuation RA symptom. This review mainly addresses the anti-angiogenesis effect of TwHf in treatment of RA...
July 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28595923/microstructural-and-ultrastructural-changes-in-the-muscle-cells-of-the-oriental-armyworm-mythimna-separata-walker-lepidoptera-noctuidae-on-treatment-with-wilforine
#16
Shujie Ma, Lin Liu, Zhiqing Ma, Xing Zhang
This study investigated the mode of action of wilforine, an alkaloid with insecticidal properties, extracted from Tripterygium wilfordii Hook f., on the microstructure and ultrastructure of the muscle cells of larvae and adults of the oriental armyworm Mythimna separata Walker. The bioassay results showed that wilforine had oral toxicity against both M. separata larvae (LC50=63μg/mL) and adults (LC50=36μg/mL). The typical toxicity sign was paralysis leading to death. Both light and electron microscope observations revealed that damage to the muscle cells increased with poisoning time in larvae and adults treated with the LC80 dose of wilforine...
June 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28572827/protective-effect-of-18%C3%AE-glycyrrhetinic-acid-against-triptolide-induced-hepatotoxicity-in-rats
#17
Guanghua Yang, Lan Wang, Xiuting Yu, Yanfeng Huang, Chang Qu, Zhenbiao Zhang, Dandan Luo, Ji Lin, Lian Zhou, Ziren Su, Xiaojun Zhang, Haiming Chen
Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological effects. However, hepatotoxicity of TP which is one of the toxic properties slows its progression in clinical application. 18β-Glycyrrhetinic acid (GA) is the main bioactive ingredient of Licorice (Glycyrrhiza glabra L.), a herbal medicine famous for its detoxification. This study aims to investigate whether GA possesses protective effect against TP-induced hepatotoxicity in rats. TP interference markedly elevated serum levels of ALT, AST, and ALP, caused evident liver histopathological changes, and elevated hepatic TNF-α, IL-6, IL-1β, and IFN-γ as well as nuclear translocation of NF-κB...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28536529/activation-of-sirt1-fxr-signaling-pathway-attenuates-triptolide-induced-hepatotoxicity-in-rats
#18
Jing Yang, Lixin Sun, Lu Wang, Hozeifa M Hassan, Xuan Wang, Phillip B Hylemon, Tao Wang, Huiping Zhou, Luyong Zhang, Zhenzhou Jiang
Triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii Hook F, has an excellent pharmacological profile of immunosuppression and anti-tumor activities, but its clinical applications are severely restricted due to its severe and cumulative toxicities. The farnesoid X receptor (FXR) is the master bile acid nuclear receptor and plays an important role in maintaining hepatic metabolism homeostasis. Hepatic Sirtuin (Sirt1) is a key regulator of the FXR signaling pathway and hepatic metabolism homeostasis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28522217/celastrol-inhibits-chondrosarcoma-proliferation-migration-and-invasion-through-suppression-cip2a-c-myc-signaling-pathway
#19
Jinhui Wu, Muchen Ding, Ningfang Mao, Yungang Wu, Chao Wang, Jiabin Yuan, Xiong Miao, Jingfeng Li, Zhicai Shi
Chondrosarcomas (CS) is the second most frequent tumors of cartilage origin. A small compound extracted from Thunder God Vine (Tripterygium wilfordii Hook. F.) called celastrol can directly bound CIP2A protein and effectively inhibit cell proliferation and induce apoptosis in several cancer cells. However, little knowledge is concern about the important role of CIP2A in CS patients and the therapeutic value of celastrol on CS. Our results showed that CIP2A and c-MYC were verified to be oncoproteins by detecting their mRNA and protein expression in 10 human CS tissues by qRT-PCR and Western blots...
May 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28514293/the-role-of-circulating-mir-146a-in-patients-with-rheumatoid-arthritis-treated-by-tripterygium-wilfordii-hook-f
#20
Zhen-Zhou Chen, Xue-Dan Zhang, Ying Chen, Ya-Bing Wu
Rheumatoid arthritis (RA) is polygenic autoimmune disease with unclear etiology. MicroRNAs (miRNAs) play a critical role in the pathogenesis of RA. The objective of this study was to evaluate the role of miR-146a in patients with RA receiving Tripterygium wilfordii Hook F (TwHF) treatment.In total, 69 patients with RA and 69 healthy controls (HC) were included in the study, and patients with RA received TwHF treatment for 24 weeks. Blood samples were collected from RA patients and HC, and peripheral blood mononuclear cells (PBMCs) were isolated...
May 2017: Medicine (Baltimore)
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