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Aparna Prasad, Matthew A Sdano, Rena J Vanzo, Patricia A Mowery-Rushton, Moises A Serrano, Charles H Hensel, E Robert Wassman
BACKGROUND: Chromosomal microarray analysis (CMA) is recommended as the first-tier clinical diagnostic test for individuals with developmental disabilities. In addition to detecting copy number variations, CMA platforms with single nucleotide polymorphism probes can detect large homozygous regions within the genome, which represent potential risk for recessively inherited disorders. METHODS: To determine the frequency in which pathogenic or likely pathogenic variants can be detected in these regions of homozygosity, we performed whole exome sequencing (WES) in 53 individuals where homozygosity was detected by CMA...
March 20, 2018: BMC Medical Genetics
C Liam Dwyer, Maximillian Soong, Alice Hunter, Jesse Dashe, Eric Tolo, N George Kasparyan
PURPOSE: We investigated whether written guidelines for surgeons and educational handouts for patients regarding safe and effective opioid use after hand surgery could reduce prescription sizes while achieving high patient satisfaction and a low refill rate. METHODS: All patients undergoing isolated carpal tunnel release or distal radius volar locked plating in a hand surgery group practice during a 6-month period were prospectively enrolled. Surgeons prescribed analgesics at their own discretion based on written guidelines...
March 12, 2018: Journal of Hand Surgery
Yan Zhang, Zhongyuan Huang, Letao Wang, Chunming Wang, Changde Zhang, Thomas E Wiese, Guangdi Wang, Kevin Eugene Riley, Zhe Wang
This work aims to face the challenge of monitoring small molecule drugs accurately and rapidly for point-of-care (POC) diagnosis in current clinical settings. Overdose of acetaminophen (AP), a commonly used OTC analgesic drug, has been determined to be a major cause of acute liver failure in the US and the UK. However, there is no rapid and accurate detection method available for this drug in the emergency room. The present study examined an AP sensing strategy that relies on a previously unexplored strong interaction between AP and the arginine (Arg) molecule...
March 15, 2018: Analytical Chemistry
Danika Johnson, Robert Mead, Korey Kennelty, David Hahn
BACKGROUND: Over-the-counter (OTC) cough remedies are lightly regulated and their potential side effects may go unrecognized. During 2015, over 282 million cough drops were sold in the United States. A Wisconsin community clinician (RM) made clinical observations suggesting that excessive use of OTC cough drops may exacerbate rather than benefit coughs. The goal of this project was to assess whether menthol in cough drops is related to worse cough symptoms. METHODS: From April 2016 through May 2017, 5 Wisconsin primary care clinics invited adolescent and adult outpatients seeking medical care for an acute or subacute cough to take a voluntary, anonymous, 10-question cough drop use survey that included age, sex, smoking status, cough severity, cough duration, and cough drop use (including type and amount)...
March 2018: Journal of the American Board of Family Medicine: JABFM
Van Luan Pham, Do-Gun Kim, Seok-Oh Ko
A core-shell nanostructure composed of zero-valent Cu (core) and Fe3 O4 (shell) (Cu@Fe3 O4 ) was prepared by a simple reduction method and was evaluated for the degradation of oxytetracycline (OTC), an antibiotic. The Cu core and the Fe3 O4 shell were verified by X-ray diffractometry (XRD) and transmission electron microscopy. The optimal molar ratio of [Cu]/[Fe] (1/1) in Cu@Fe3 O4 created an outstanding synergic effect, leading to >99% OTC degradation as well as H2 O2 decomposition within 10min at the reaction conditions of 1g/L Cu@Fe3 O4 , 20mg/L OTC, 20mM H2 O2 , and pH3...
March 10, 2018: Science of the Total Environment
Wei Fu, Xingyuan He, Sheng Xu, Wei Chen, Yan Li, Bo Li, Lili Su, Qin Ping
Ground-level ozone (O3 ) pollution has been widely concerned in the world, particularly in the cities of Asia, including China. Elevated O3 concentrations have potentially influenced growth and nutrient cycling of trees in urban forest. The decomposition characteristics of urban tree litters under O3 exposure are still poorly known. Ginkgo biloba is commonly planted in the cities of northern China and is one of the main tree species in the urban forest of Shenyang, where concentrations of ground-level O3 are very high in summer...
2018: PeerJ
Louise Crowe, Vicki Anderson, Winita Hardikar, Avihu Boneh
Ornithine Trans-Carbamylase (OTC) deficiency is the most common disorder of the urea cycle. Cognitive impairments in skills such as attention and executive function have been reported in individuals with OTC deficiency who are managed with medication. In some cases, children undergo liver transplantation (LTx) to correct the metabolic defect. The metabolic and medical outcomes of LTx are generally good. However, little is known about the impacts on cognition. In this study, four children (three female) completed detailed neuropsychological batteries prior to (n = 6) and following LTx (n = 8 assessments)...
March 10, 2018: JIMD Reports
Paschalis Gavriilidis, Konstantinos Katsanos
OBJECTIVES: The survival benefits, oncological adequacy, effectiveness, and safety of laparoscopic transverse colectomy (LTC) were compared with that of open transverse colectomy (OTC) using a meta-analysis. METHODS: EMBASE, Medline, Cochrane library, and Google scholar databases were searched for the last 20 years. Meta-analyses were performed using both fixed-effects and random-effects models. Five-year disease-free survival and overall survival were estimated using the inverse variance hazard ratio method...
March 9, 2018: World Journal of Surgery
Sarah S Sheldon, Kyle E Mathewson
The phase of alpha (8-12 Hz) brain oscillations have been associated with moment to moment changes in visual attention and awareness. Previous work has demonstrated that endogenous oscillations and subsequent behavior can be modulated by oscillating transcranial current stimulation (otCS). The purpose of the current study is to establish the efficacy of cathodal otCS for modulation of the ongoing alpha brain oscillations, allowing for modulation of individual's visual perception. Thirty-six participants performed a target detection with sham and 10-Hz cathodal otCS...
2018: Frontiers in Neuroscience
Saul Shiffman, Deena R Battista, Judith P Kelly, Mary K Malone, Rachel B Weinstein, David W Kaufman
AIMS: To estimate prevalence of excess intake of acetaminophen, and investigate seasonal variations therein. METHODS: Between 2011 and 2016, 14,481 US adults who used acetaminophen in the preceding 30 days were sampled from national online panels and completed a detailed online daily diary of acetaminophen medication use for 7 days. Respondents were not told the study concerned acetaminophen. Cold/flu season (CFS), identified using Google© Trends data, was contrasted to off-season in symptoms, use of acetaminophen medications, and consumption exceeding 4 grams (the recommended daily maximum)...
March 7, 2018: British Journal of Clinical Pharmacology
Y M Kim, A N Ha, J W Kim, S J Kim
OBJECTIVES: In this double-blind randomized study, we evaluated the safety and efficacy of over-the-counter (OTC) bleaching products that included 2.9% hydrogen peroxide (H2 O2 ) with two methods of application: strip and paint-on. METHODS AND MATERIALS: A commonly used product was selected for each type (strip and paint-on) of OTC bleaching agent. In total, 75 volunteers were assigned randomly into five groups: two test groups (strip and paint-on), two negative control groups (products without H2 O2 ), and one positive control group (dentist-supervised home bleaching)...
March 7, 2018: Operative Dentistry
Federico M Winkler, Ricardo García, María V Valdivia, Karin B Lohrmann
Withering Syndrome (WS) is a lethal disease that affects abalone species in both wild and farmed populations. This infection, caused by the rickettsial-like intracellular organism (RLO) Candidatus Xenohaliotis californiensis, can severely impair the normal development of affected animals, and ultimately, their survival. The most common line of action against the WS has been the use of antibiotics, specifically oxytetracycline (OTC), administered via intramuscular injection and per os via medicated feed. In the present study, we have assessed the effectiveness of OTC baths as therapeutic treatment for the control of the WS agent in H...
February 28, 2018: Journal of Invertebrate Pathology
Bao-Shan Xing, Ren-Cun Jin
To facilitate the use of partial nitritation (PN) in nitrogen removal processes for livestock wastewater, this work investigated the inhibitory effects of heavy metals and antibiotics on the nitrifying bacterial activities of the PN processes. Biomass was collected from a continuous-flow internal-loop airlift reactor and cultured with fixed ammonium concentrations of 921 mg N L-1 . Batch activity tests were conducted to determine the specific oxygen uptake rate. The individual and interactive inhibitory effects of Zn2+ , Cu2+ , oxytetracycline (OTC) and sulfamethazine (SMZ) were evaluated using an orthogonal test...
February 22, 2018: Chemosphere
S E Gellert, S E Pors, S G Kristensen, A M Bay-Bjørn, E Ernst, C Yding Andersen
PURPOSE: The purpose of the study is to review all peer-reviewed published reports of women receiving ovarian tissue transplantation (OTT) with frozen/thawed tissue (OTC) with respect to age, diagnosis, transplantation site, fertility outcome, and potential side effects, including data from all women in the Danish program. METHODS: A systematic review of the literature was performed in PubMed combined with results from all patients who had received OTT in Denmark up to December 2017...
March 1, 2018: Journal of Assisted Reproduction and Genetics
Maria Mulka-Gierek, Bartosz Foroncewicz, Leszek Pączek, Elżbieta Wawiórko, Joanna Kamińska, Maciej Kosieradzki, Piotr Małkowski, Bianka Małczuk, Sławomir Nazarewski, Krzysztof Mucha
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics are the most commonly used drugs and are increasingly available over-the-counter (OTC). In certain groups of patients, including kidney transplant recipients, their use may be complicated by adverse effects or drug interactions. The aim of our study was to assess the causes and frequency of OTC NSAIDs or analgesics use, as well as the awareness of related side effects. MATERIAL AND METHODS We enrolled 94 randomly selected kidney transplant recipients, who represented 5% of all kidney transplant recipients at our center...
March 2, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Tessa Kelly, Kelly M Conn, Matthew Zak
OBJECTIVES: Objectives of this study were to 1) assess and compare knowledge and literacy of over-the-counter (OTC) medications among middle and high students and 2) to assess student self-identified lack of knowledge regarding OTC medications. METHODS: A convenience sample of suburban adolescent students completed a two-part survey about OTC medications; part 1 included demographics and baseline knowledge of OTCs, part 2 included medication label interpretation (literacy)...
February 26, 2018: Academic Pediatrics
Takuya Aoki, Yosuke Yamamoto, Tatsuyoshi Ikenoue, Yoshihiro Onishi, Shunichi Fukuhara
In the present study, we aimed to identify multimorbidity patterns in a Japanese population and investigate whether these patterns have differing effects on polypharmacy and dosage frequency. Data was collected on 17 chronic health conditions via nationwide cross-sectional survey of 3,256 adult Japanese residents. Factor analysis was performed to identify multimorbidity patterns, and associations were determined with excessive polypharmacy [concurrent use of ≥ 10 prescription or over-the-counter (OTC) medications] and higher dosage frequency ( ≥ 3 doses per day)...
February 28, 2018: Scientific Reports
Elena Losina, Ilana M Usiskin, Savannah R Smith, James K Sullivan, Karen C Smith, David J Hunter, Stephen P Messier, A David Paltiel, Jeffrey N Katz
OBJECTIVE: The cost-effectiveness of the recently-introduced generic celecoxib in knee OA has not been examined. METHOD: We used the Osteoarthritis Policy (OAPol) Model, a validated computer simulation of knee OA, to evaluate long-term clinical outcomes, costs, and cost-effectiveness of generic celecoxib in persons with knee OA. We examined eight treatment strategies consisting of generic celecoxib, over-the-counter (OTC) naproxen, or prescription naproxen, with or without prescription or OTC proton-pump-inhibitors (PPIs) to reduce gastrointestinal (GI) toxicity...
February 23, 2018: Osteoarthritis and Cartilage
D Di Stasio, A N Romano, R S Paparella, C Gentile, G Minervini, R Serpico, V Candotto, L Laino
YouTube™ is increasingly being used by patients to obtain health-related information. No studies have evaluated the content of YouTube™ videos on children oral thrush. The aim of this work is to examine the quality of information offered by this platform about oral thrush in children. Searching term “oral thrush in children” (OTC) displayed a total of 2.790 results. Of the top 60 videos analyzed, 27 were excluded. The main source of upload was from generalist information YouTube® channels (GC) followed by healthcare professionals (HP), individual users (IU), and healthcare information channels (HC); usefulness of videos is successfully correlated with the number of visualization, number of likes and viewing rate and was interdependent with the number of visualizations, number of likes and VR...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Sara Modig, Sölve Elmståhl
Background Renal elimination normally decreases with age. Nonsteroidal antiinflammatory drugs (NSAIDs) carry a risk of additional kidney damage. Objective The aims of this study were to assess the prevalence of NSAIDs in the elderly (aged ≥ 65) population in Sweden, explore reasons for any possible differences in the level of use and assess their kidney functions. Setting Data were obtained from the cohort study Good Aging in Skåne, Sweden. Patients aged 65 or more were included. Methods Medication lists were collected as well as variables such as cognition and education levels...
February 19, 2018: International Journal of Clinical Pharmacy
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