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https://www.readbyqxmd.com/read/28915256/optical-coherence-tomography-angiography-of-the-peripapillary-capillaries-in-primary-open-angle-and-normal-tension-glaucoma
#1
Ryoko Igarashi, Shun Ochiai, Yuta Sakaue, Aki Suetake, Ryu Iikawa, Testuya Togano, Fuuko Miyamoto, Daiki Miyamoto, Takeo Fukuchi
OBJECTIVES: To evaluate the vascular architecture of the radial peripapillary capillaries (RPCs) and its relation with visual function in patients with open-angle glaucoma (OAG) and normal-tension glaucoma using spectral-domain optical coherence tomography (SD-OCT) angiography. SUBJECTS AND METHODS: Clear OCT angiography images of blood vessels in the optic disc and peripapillary retina were obtained from 52 patients (52 eyes) aged 55.42±10.64 (range 28-72) years with primary OAG...
2017: PloS One
https://www.readbyqxmd.com/read/28894633/establishment-of-application-guidance-for-otc-non-kampo-crude-drug-extract-products-in-japan
#2
REVIEW
Layla Somekawa, Hikoichiro Maegawa, Shinsuke Tsukada, Takatoshi Nakamura
Currently, there are no standardized regulatory systems for herbal medicinal products worldwide. Communication and sharing of knowledge between different regulatory systems will lead to mutual understanding and might help identify topics which deserve further discussion in the establishment of common standards. Regulatory information on traditional herbal medicinal products in Japan is updated by the establishment of Application Guidance for over-the-counter non-Kampo Crude Drug Extract Products. We would like to report on updated regulatory information on the new Application Guidance...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28894402/attachment-proliferation-and-morphological-properties-of-human-dermal-fibroblasts-on-ovine-tendon-collagen-scaffolds-a-comparative-study
#3
Fauzi Mh Busra, Yogeswaran Lokanathan, Masrina Mohd Nadzir, Aminuddin Saim, Ruszymah Bt Hj Idrus, Shiplu Roy Chowdhury
INTRODUCTION: Collagen type I is widely used as a biomaterial for tissue-engineered substitutes. This study aimed to fabricate different three-dimensional (3D) scaffolds using ovine tendon collagen type I (OTC-I), and compare the attachment, proliferation and morphological features of human dermal fibroblasts (HDF) on the scaffolds. METHODS: This study was conducted between the years 2014 to 2016 at the Tissue Engineering Centre, UKM Medical Centre. OTC-I was extracted from ovine tendon, and fabricated into 3D scaffolds in the form of sponge, hydrogel and film...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28888854/quantitation-of-phenylbutyrate-metabolites-by-uplc-ms-ms-demonstrates-inverse-correlation-of-phenylacetate-phenylacetylglutamine-ratio-with-plasma-glutamine-levels
#4
Yi Jiang, Mohammed Almannai, V Reid Sutton, Qin Sun, Sarah H Elsea
Urea cycle disorders (UCDs) are genetic conditions characterized by nitrogen accumulation in the form of ammonia and caused by defects in the enzymes required to convert ammonia to urea for excretion. UCDs include a spectrum of enzyme deficiencies, namely n-acetylglutamate synthase deficiency (NAGS), carbamoyl phosphate synthetase I deficiency (CPS1), ornithine transcarbamylase deficiency (OTC), argininosuccinate lyase deficiency (ASL), citrullinemia type I (ASS1), and argininemia (ARG). Currently, sodium phenylbutyrate and glycerol phenylbutyrate are primary medications used to treat patients with UCDs, and long-term monitoring of these compounds is critical for preventing drug toxic levels...
August 31, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28888623/effect-of-different-oral-oxytetracycline-treatment-regimes-on-selection-of-antimicrobial-resistant-coliforms-in-nursery-pigs
#5
Ana Herrero-Fresno, Camilla Zachariasen, Nanna Nørholm, Anders Holm, Lasse Engbo Christiansen, John Elmerdahl Olsen
A major concern derived from using antimicrobials in pig production is the development of resistance. This study aimed to assess the impact of selected combinations of oral dose and duration of treatment with oxytetracycline (OTC) on selection of tetracycline resistant (TET-R) coliforms recovered from swine feces. The work encompassed two studies: 1) OTC 5mg/kg and 20mg/kg were administered to nursery pigs for 3 and 10days, respectively, under controlled experimental conditions, and 2) 10mg/kg, 20mg/kg and 30mg/kg OTC were given to a higher number of pigs for 6, 3 and 2days, respectively, under field conditions...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28887792/liver-failure-as-the-presentation-of-ornithine-transcarbamylase-deficiency-in-a-13-month-old-female
#6
Farrah Rajabi, Lance H Rodan, Maureen M Jonas, Janet S Soul, Nicole J Ullrich, Ann Wessel, Susan E Waisbren, Wen-Hann Tan, Gerard T Berry
Ornithine transcarbamylase deficiency (OTCD) is an X-linked urea cycle disorder with variable expressivity in heterozygous females. While liver function testing is often abnormal in patients with OTCD, liver failure is uncommon on presentation. A 13-month-old female with no significant past medical history presented with irritability, right arm weakness, and decreased appetite. Initial workup revealed hepatic dysfunction with an INR of 3.4, ammonia level of 75 μmol/L, and abnormal brain MRI with gyral edema with restricted diffusion, and patchy signal abnormality in basal ganglia...
September 9, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28886567/expanding-the-application-scope-of-on-farm-biopurification-systems-effect-and-removal-of-oxytetracycline-in-a-biomixture
#7
David Jiménez-Gamboa, Víctor Castro-Gutiérrez, Ericka Fernández-Fernández, Susana Briceño-Guevara, Mario Masís-Mora, Juan Salvador Chin-Pampillo, Marielos Mora-López, Elizabeth Carazo-Rojas, Carlos E Rodríguez-Rodríguez
Antibiotic-containing wastewaters produced in agricultural activities may depress the pesticide-degrading capacity of biomixtures contained in biopurification systems. This work aimed to assay the effect of oxytetracycline (OTC) on the removal of carbofuran (CFN) in an optimized biomixture, and to determine the capacity of the system to dissipate OTC. During co-application of CFN+OTC, CFN removal and its accelerated degradation were not negatively affected. Similarly, different doses of OTC (10-500mgkg(-1)) did not significantly affect CFN mineralization, and the process even exhibited a hormetic-like effect...
August 26, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28883213/present-status-of-displaying-pharmaceutical-products-for-sale-on-flea-market-applications-for-smartphones-and-the-responses-to-illicit-selling-by-service-providers
#8
Keiko Kishimoto, Tomoe Takeuchi, Noriko Fukushima
  In Japan, a pharmacy or drug store license is required for selling pharmaceutical products. However, civilians without a pharmacy or drug store license are displaying pharmaceutical products for sale on a flea market application, which is illegal dealing. This study discussed the modality for implementing countermeasures for the illicit selling of pharmaceutical products. We extracted pharmaceutical products displayed for sale on three flea market applications (Mercari, Rakuma, Fril) on one day. One hundred and eighty-one pharmaceutical products were displayed (49 on Mercari, 86 on Rakuma, and 46 on Fril)...
September 5, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28881225/the-oxidative-stress-response-of-oxytetracycline-in-the-ciliate-pseudocohnilembus-persalinus
#9
Chongnv Wang, Xuming Pan, Yawen Fan, Ying Chen, Weijie Mu
Oxytetracycline (OTC) is commonly employed in fish farms to prevent bacterial infections in China, and because of their widely and intensive use, the potential harmful effects on organisms in aquatic environment are of great concern. Ciliates play an important role in aquatic food webs as secondary producers, and Pseudocohnilembus persalinus, is one kind of them which are easily found in fish farms, surviving in polluted water. Therefore, using P. persalinus as experimental models, this study investigated the effects of oxytetracycline (OTC) on the growth, antioxidant system and morphological damage in pollution-resistant ciliates species...
August 24, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28868581/in-human-brain-ornithine-transcarbamylase-otc-immunoreactivity-is-strongly-expressed-in-a-small-number-of-nitrergic-neurons
#10
Hans-Gert Bernstein, Hendrik Dobrowolny, Gerburg Keilhoff, Johann Steiner
There is recent evidence for ornithine transcarbamylase (OTC) expression in adult human brain. We decided to immunocytochemically map OTC throughout brain, and to further characterize OTC-immunopositive neurons. By using double immunolabeling technique for OTC and neuronal nitric oxide synthase (nNOS) OTC protein expression was revealed in a small subset of nitrergic (nNOS) neurons. Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons...
September 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28867721/inhibitory-effect-of-oxethazaine-on-midazolam-metabolism-in-rats
#11
Hokuto Namba, Yuki Nishimura, Norimitsu Kurata, Mariko Iwase, Takahito Hirai, Yuji Kiuchi
There have been few reports concerning to the drug-drug interactions (DDIs) with OTC drugs although an increase in the use of OTC drugs in recent years. This current study was conducted to clarify the DDIs through CYP3A inhibition by oxethazaine (OXZ), an antacid available as an OTC drug. Midazolam (MDZ) was used as a probe drug for CYP3A activity. In an in vivo study, a single oral dose of OXZ (50 mg/kg) was administered to rats 30, 60, or 120 min before oral MDZ administration (15 mg/kg). Serum concentrations of MDZ were analyzed by HPLC, and its pharmacokinetic parameters were compared with a water-treated control group...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28866830/a-transportation-network-for-human-ovarian-tissue-is-indispensable-to-success-for-fertility-preservation
#12
REVIEW
K Kyono, T Hashimoto, M Toya, M Koizumi, C Sasaki, S Shibasaki, N Aono, Y Nakamura, R Obata, N Okuyama, Y Ogura, H Igarashi
PURPOSE: The purpose of this study was to examine the efficacy of an ovarian tissue transportation network for fertility preservation (FP) for cancer patients in Japan. METHODS: PubMed was searched for papers on transportation of human ovarian tissue for FP. We analyzed population, area, number of cancer patients for ovarian tissue cryopreservation (OTC), quality control/assessment and safety, cost of a cryopreservation center for the building for 30 years, and medical fees of cancer patients (operation, cryopreservation, and storage of ovarian tissue)...
September 2, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28863363/operating-conditions-influence-microbial-community-structures-elimination-of-the-antibiotic-resistance-genes-and-metabolites-during-anaerobic-digestion-of-cow-manure-in-the-presence-of-oxytetracycline
#13
Gokhan Turker, Çağrı Akyol, Orhan Ince, Sevcan Aydin, Bahar Ince
The way that antibiotic residues in manure follow is one of the greatest concerns due to its potential negative impacts on microbial communities, the release of metabolites and antibiotic resistant genes (ARGs) into the nature and the loss of energy recovery in anaerobic digestion (AD) systems. This study evaluated the link between different operating conditions, the biodegradation of oxytetracycline (OTC) and the formation of its metabolites and ARGs in anaerobic digesters treating cow manure. Microbial communities and ARGs were determined through the use of quantitative real-time PCR...
August 29, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28833330/patients-intention-to-consume-prescribed-and-non-prescribed-medicines-a-study-based-on-the-theory-of-planned-behaviour-in-selected-european-countries
#14
A Kamekis, A Bertsias, J Moschandreas, E Petelos, M Papadakaki, V Tsiantou, A Saridaki, E K Symvoulakis, K Souliotis, N Papadakis, T Faresjö, A Faresjö, L Martinez, D Agius, Y Uncu, T Sengezer, G Samoutis, J Vlcek, A Abasaeed, B Merkouris, C Lionis
WHAT IS KNOWN AND OBJECTIVE: Polypharmacy has a significant impact on patients' health with overall expenditure on over-the-counter (OTC) medicines representing a substantial burden in terms of cost of treatment. The aim of this study, which was conducted within the framework of a European Project funded by the European Union under the Seventh Framework Programme and was entitled OTC-SOCIOMED, was to report on possible determinants of patient behaviour regarding the consumption of medicines, and particularly OTCs, in the context of primary care...
August 19, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28831632/utilization-of-bioimpedance-spectroscopy-in-the-prevention-of-chronic-breast-cancer-related-lymphedema
#15
David I Kaufman, Chirag Shah, Frank A Vicini, Marisa Rizzi
BACKGROUND: This analysis was performed to assess the impact of early intervention following prospective surveillance using bioimpedance spectroscopy (BIS) to detect and manage breast cancer-related lymphedema (BCRL). METHODS: From 8/2010 to 12/2016, 206 consecutive patients were evaluated with BIS. The protocol included pre-operative assessment with L-Dex as well as post-operative assessments at regular intervals. Patients with L-Dex scores >10 from baseline were considered to have subclinical BCRL and were treated with over-the-counter (OTC) compression sleeve for 4 weeks...
August 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28830818/review-of-anti-inflammatory-immune-modulatory-and-wound-healing-properties-of-molluscs
#16
REVIEW
Tarek B Ahmad, Lei Liu, Michael Kotiw, Kirsten Benkendorff
ETHNOPHARMACOLOGICAL RELEVANCE: This review focuses on traditional and contemporary anti-inflammatory uses of mollusc-derived products summarising all the in vitro, in vivo and human clinical trials that have tested the anti-inflammatory activity of molluscan natural products. Inflammatory conditions, burns and wounds have been an ongoing concern for human health since the early era of civilisation. Many texts from ancient medicine have recorded the symptoms, signs and treatments for these conditions...
August 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28822927/comparative-ozone-responses-of-cutleaf-coneflowers-rudbeckia-laciniata-var-digitata-var-ampla-from-rocky-mountain-and-great-smoky-mountains-national-parks-usa
#17
Howard S Neufeld, Jennifer Johnson, Robert Kohut
Cutleaf coneflower (Rudbeckia laciniata L. var. digitata) is native to Great Smoky Mountains National Park (GRSM) and an ozone bioindicator species. Variety ampla, whose ozone sensitivity is less well known, is native to Rocky Mountain National Park (ROMO). In the early 2000s, researchers found putative ozone symptoms on var. ampla and rhizomes were sent to Appalachian State University to verify that the symptoms were the result of ozone exposure. In 2011, potted plants were exposed to ambient ozone from May to August...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28813782/urea-cycle-pathway-targeted-therapeutic-action-of-naringin-against-ammonium-chloride-induced-hyperammonemic-rats
#18
Arumugam Ramakrishnan, Natesan Vijayakumar
Ammonia is a well-known neurotoxin that causes liver disease and urea cycle disorder. Excessive ammonia content in the blood leads to hyperammonemic condition and affects both excitatory and inhibitory neurotransmission including brain edema and coma. Naringin, a plant bioflavonoid present in various citrus fruits and mainly extracted from the grape fruit. This study was designed to assess the protective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitoneal injections (i...
August 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28812451/nonmedical-use-of-over-the-counter-medications-is-significantly-associated-with-nonmedical-use-of-prescription-drugs-among-university-students
#19
Vi T Le, Abigail Norris Turner, Anne McDaniel, Kenneth M Hale, Christina Athas, Nicole C Kwiek
OBJECTIVE: To examine the association between nonmedical use of over-the-counter medications (NMUOTC) and nonmedical use of prescription drugs (NMUPD). PARTICIPANTS: University students surveyed on NMUOTC and NMUPD between August and December 2011 (N = 939). METHODS: Cross-sectional data analysis of online survey. RESULTS: The majority of respondents were women, undergraduate, Caucasian, and not affiliated with Greek life...
August 16, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28812385/increased-acetaminophen-related-calls-to-finnish-pic-better-reflect-acetaminophen-sales-than-serious-poisonings
#20
Mikko J Parry, Helena Isoniemi, Anna-Maria Koivusalo, Kalle Hoppu
OBJECTIVE: Acetaminophen (APAP) or paracetamol is a commonly encountered medicine in poisonings. We studied the changes in APAP related calls to the Finnish poison information centre (FPIC), and serious intoxications, involving hepatotoxicity or death in 2001-2014. These data were compared with paracetamol sales in Finland. METHODS: This is a retrospective analysis of the FPIC database calls, national cause of death registry, registries of liver transplantations and molecular adsorbent recycling system (MARS)-treated patients from Helsinki University Hospital together with the National Institute of Health and Welfare registry of patients hospitalized...
August 16, 2017: Clinical Toxicology
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