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https://www.readbyqxmd.com/read/27925709/estimation-of-dietary-supplements-intake-in-a-selected-group-of-women-over-50-and-the-risk-assessment-of-interactions-between-the-ingredients-of-dietary-supplements-and-drugs
#1
Joanna Sadowska, Magda Bruszkowska
Background: Concurrent use of dietary supplements and drugs may result in complications of pharmacotherapy due to possible interactions between their ingredients. Objectives: The aim of the survey was to estimate the intake of dietary supplements in a group of women over 50 and to analyse the risk of interactions between the ingredients of dietary supplements and drugs taken by the women. Material and Methods: The study was carried out among 146 women over 50 years of age...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27923571/a-simple-dried-blood-spot-method-for-in-vivo-measurement-of-ureagenesis-by-gas-chromatography-mass-spectrometry-using-stable-isotopes
#2
Gabriella Allegri, Sereina Deplazes, Hiu Man Viecelli, Déborah Mathis, Ralph Fingerhut, Johannes Häberle, Beat Thöny
BACKGROUND: Clinical management of inherited or acquired hyperammonemia depends mainly on the plasma ammonia level which is not a reliable indicator of urea cycle function as its concentrations largely fluctuate. The gold standard to assess ureagenesis in vivo is the use of stable isotopes. METHODS: Here we developed and validated a simplified in vivo method with [(15)N]ammonium chloride ([(15)N]H4Cl) as a tracer. Non-labeled and [(15)N]urea were quantified by GC-MS after extraction and silylation...
December 3, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27913897/rainbow-trout-oncorhynchus-mykiss-pro-oxidant-and-genotoxic-responses-following-acute-and-chronic-exposure-to-the-antibiotic-oxytetracycline
#3
Sara Rodrigues, Sara C Antunes, Alberto T Correia, Bruno Nunes
Oxytetracycline (OTC), an antibacterial agent, is extensively used in aquaculture practices all over the world, but also in human and veterinary medicines. Because of its intensive use, low rates of absorption by treated animals, inadequate disposal, and low efficiency of removal in wastewater treatment plants, the potential harmful effects on aquatic organisms are of great concern. This work aimed to assess the effects of this antibiotic in rainbow trout, following both acute and chronic exposures. Catalase (CAT), total glutathione peroxidase (GPx), glutathione reductase (GRed) activities and lipid peroxidation (TBARS levels) were quantified as oxidative stress biomarkers, in gills and liver...
December 2, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27906534/food-and-drug-administration-review-and-action-on-over-the-counter-time-and-extent-applications-final-rule
#4
(no author information available yet)
The Food and Drug Administration (FDA or Agency) is amending its nonprescription (over-the-counter or OTC) drug regulations. This final rule supplements the time and extent application (TEA) process for OTC drugs by establishing timelines and performance metrics for FDA's review of non-sunscreen TEAs, as required by the Sunscreen Innovation Act (SIA). It also amends the existing TEA process to include filing determination and withdrawal provisions to make the TEA process more efficient.
November 23, 2016: Federal Register
https://www.readbyqxmd.com/read/27905078/improving-the-provision-of-otc-medication-information-in-community-pharmacies-in-poland
#5
Anna Piecuch, Magdalena Makarewicz-Wujec, Małgorzata Kozłowska-Wojciechowska
Background An informed or shared decision-making model is desirable to support the choice of over-the-counter (OTC) medications in pharmacies: it respects patient empowerment in self-medication. Such a model is achievable provided that pharmacists are a credible, competent information source open to patient needs. Objective To study the dependencies among selected factors that may influence the provision of OTC medication information. The study was conducted from the perspective of a community pharmacist. Method The study consisted of an auditorium survey with a self-administered questionnaire...
November 30, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27903094/effects-of-self-complementarity-codon-optimization-transgene-and-dose-on-liver-transduction-with-aav8
#6
Peter Bell, Lili Wang, Shu-Jen Chen, Hongwei Yu, Yanqing Zhu, Mohamad Nayal, Zhenning He, John White, Deborah Lebel-Hagan, James M Wilson
Numerous methods of vector design and delivery have been employed in an attempt to increase transgene expression following AAV-based gene therapy. Here, we conducted a gene transfer study in mice to compare the effects of vector self-complementarity (double- or single-stranded DNA), codon optimization of the transgene, and vector dose on transgene expression levels in liver. Two different reporter genes were used: human ornithine transcarbamylase (hOTC) detected by immunofluorescence, and enhanced green fluorescent protein (EGFP) detected by direct fluorescence...
November 30, 2016: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/27898329/simultaneous-removal-of-structurally-different-pesticides-in-a-biomixture-detoxification-and-effect-of-oxytetracycline
#7
Alejandra Huete-Soto, Mario Masís-Mora, Verónica Lizano-Fallas, Juan Salvador Chin-Pampillo, Elizabeth Carazo-Rojas, Carlos E Rodríguez-Rodríguez
The biopurification systems (BPS) used for the treatment of pesticide-containing wastewater must present a versatile degrading ability, in order to remove different active ingredients according to the crop protection programs. This work aimed to assay the simultaneous removal of several pesticides (combinations of herbicides/insecticides/fungicides, or insecticides/fungicides) in a biomixture used in a BPS over a period of 115 d, and in the presence of oxytetracycline (OTC), an antibiotic of agricultural use that could be present in wastewater from agricultural pesticide application practices...
November 26, 2016: Chemosphere
https://www.readbyqxmd.com/read/27897219/timelike-curves-can-increase-entanglement-with-locc
#8
Subhayan Roy Moulick, Prasanta K Panigrahi
We study the nature of entanglement in presence of Deutschian closed timelike curves (D-CTCs) and open timelike curves (OTCs) and find that existence of such physical systems in nature would allow us to increase entanglement using local operations and classical communication (LOCC). This is otherwise in direct contradiction with the fundamental definition of entanglement. We study this problem from the perspective of Bell state discrimination, and show how D-CTCs and OTCs can unambiguously distinguish between four Bell states with LOCC, that is otherwise known to be impossible...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896473/experience-with-oral-emergency-contraception-since-the-otc-switch-in-germany
#9
Marion Kiechle, Miriam Neuenfeldt
PURPOSE: In March 2015, the oral emergency contraceptives levonorgestrel (LNG) and ulipristal acetate (UPA) were released from prescription-only status in Germany. The main research question is to analyse whether the OTC status of oral emergency contraceptives has an influence on the patterns of use. METHODS: All information is based on searches for public domain sources on emergency contraception. Searches were made for scientific publications, statistics, and surveys...
November 28, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27891735/hyperammonemia-in-ornithine-transcarbamylase-deficient-recipients-following-living-donor-liver-transplantation-from-heterozygous-carrier-donors
#10
Tri Hening Rahayatri, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Yoshihiro Hirata, Hiroyuki Kanazawa, Vidyadhar Mali, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara
Ornithine transcarbamylase deficiency (OTCD) is a urea cycle disorder of X-linked inheritance, affecting the detoxification of excess nitrogen and leading to hyperammonemia (hyper-NH3 ). Living donor liver transplantation (LDLT) has been applied for the treatment of OTCD. This case series retrospectively reviewed two OTCD patients who experienced hyper-NH3 following LDLT. The first case was a 5-year-old girl who had onset of OTCD at 2 years of age. Ornithine transcarbamylase (OTC) enzyme activity was 62% for the donor and 15% for the recipient...
November 28, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27890394/purchase-habits-use-of-paracetamol-and-information-sources-on-a-reregulated-swedish-pharmacy-market-a-population-based-study
#11
T Hedenrud, H Håkonsen
Considering the general lack of knowledge on how over-the-counter paracetamol is used combined with the reported increase in paracetamol poisonings after the reregulation of the Swedish pharmacy market in 2009, we aimed to analyze purchase habits and use of paracetamol in Sweden. A further aim was to investigate sources of information about paracetamol. Data were collected in October 2015 through the Citizen Panel, a Web-based panel encompassing over 50,000 Swedes. A stratified sample of 6000 (aged 18 years and older) was emailed a survey invitation...
November 19, 2016: Health Policy
https://www.readbyqxmd.com/read/27890325/functional-coupling-between-frontoparietal-and-occipitotemporal-pathways-during-action-and-perception
#12
R Matthew Hutchison, Jason P Gallivan
Several lines of evidence point to areas in the occipitotemporal pathway as being critical in the processes of visual perception and object recognition. Much less appreciated, however, is the role that this pathway plays in object-related processing for the purposes of visually guided action. Here, using functional MRI (fMRI) and functional connectivity (FC) measures, we examined interactions between areas in frontoparietal cortex (FPC) involved in grasping, reaching, eye movements, and tool use and areas in occipitotemporal cortex (OTC) involved in object-, face-, scene-, body-, tool-, and motion-related processing, both during the performance of sensorimotor and visual-perceptual tasks, as well as during passive fixation (resting-state)...
November 9, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27881100/high-prevalence-of-non-steroidal-anti-inflammatory-drug-use-among-acute-kidney-injury-survivors-in-the-southern-community-cohort-study
#13
Loren Lipworth, Khaled Abdel-Kader, Jennifer Morse, Thomas G Stewart, Edmond K Kabagambe, Sharidan K Parr, Kelly A Birdwell, Michael E Matheny, Adriana M Hung, William J Blot, T Alp Ikizler, Edward D Siew
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for future adverse kidney and cardiovascular outcomes. The objective of our study was to examine the prevalence and predictors of NSAID use among AKI survivors. METHODS: The Southern Community Cohort Study is a prospective study of low-income adults aged 40-79 in the southeastern US...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27879173/residue-depletion-of-oxytetracycline-otc-and-4-epi-oxytetracycline-4-epi-otc-in-broiler-chicken-s-claws-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#14
J Cornejo, E Pokrant, D Araya, C Briceño, H Hidalgo, A Maddaleno, C Araya-Jordán, B San Martin
Antibiotics are widely used in poultry production for treatment of bacterial diseases. However, residues may remain in products and by-products destined for human consumption or animal feeding. The claws of chickens are a by-product from the poultry industry, which can directly or indirectly enter the food chain as meals destined to feed other productive animals. Thus, it becomes necessary to determine and quantify antimicrobial residues present in this matrix. The objective of the present study was to assess the depletion of oxytetracycline (OTC) and its metabolite 4-epi-OTC in broiler chicken's claws...
November 23, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27875442/otc-antacids-containing-aspirin-carry-risk-of-bleeding
#15
Diane S Aschenbrenner
No abstract text is available yet for this article.
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27875056/opioid-nsaid-and-otc-analgesic-medications-for-dental-procedures-pearl-network-findings
#16
Ying Jo Wong, James Keenan, Keith Hudson, Henry Bryan, Frederick Naftolin, Van P Thompson, Ronald G Craig, Don Vena, Damon Collie, Hongyu Wu, Abigail G Matthews, Ashley C Grill, Frederick A Curro
OBJECTIVE: Dental treatment is often categorized as a moderately or severely painful experience; however, no clinical data reported by the patient and dentist currently exists to support this degree of pain. This has contributed possibly to the overprescribing of analgesics, in particular the opioid class of medications. The primary objective of the study was to document the dentists' postprocedural prescriptions and recommendations for analgesic medications and their effectiveness for a 5-day period...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27874174/compound-heterozygous-mutations-in-the-ift140-gene-cause-opitz-trigonocephaly-c-syndrome-in-a-patient-with-typical-features-of-a-ciliopathy
#17
Christian Peña-Padilla, Christian R Marshall, Susan Walker, Stephen W Scherer, Gerónimo Tavares-Macías, Gladys Razo-Jiménez, Lucina Bobadilla-Morales, Elizabeth Acosta-Fernández, Alfredo Corona-Rivera, Roberto Mendoza-Londono, Jorge Román Corona-Rivera
We report on an infant with Opitz trigonocephaly C syndrome (OTCS), who also had manifestations of ciliopathy, including short ribs (non-asphyxiating), trident acetabular roofs, postaxial polydactyly cone-shaped epiphyses, and dysplasia of the renal, hepatic and pancreatic tissues. To investigate the molecular cause, we used an exome sequencing strategy followed by Sanger sequencing. Two rare variants, both predicted to result in loss of functional protein, were identified in the IFT140 gene; a substitution at the splice donor site of exon 24 (c...
November 22, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27851339/1704-hyperammonemia-following-chemotherapy-in-a-patient-with-suspected-latent-otc-deficiency
#18
Everett Lally, Janine Elizabeth Zee-Cheng, Orozco Jennifer, Jessica Scott Schwoerer, Megan Peters
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27848131/removal-of-tetracycline-and-oxytetracycline-from-water-by-magnetic-fe3o4-graphene
#19
Yan Zhang, Zhe Jiao, Yongyou Hu, Sihao Lv, Hongbo Fan, Yanyan Zeng, Jun Hu, Mianmian Wang
In this paper, Fe3O4@graphene (Fe3O4@G) magnetic nanocomposite was prepared via in situ precipitation method for the removal of oxytetracycline (OTC) and tetracycline (TC) from aqueous solution. The properties of the prepared nanocomposite were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and magnetic property measurement system (MPMS). Adsorption isotherm and kinetics of OTC and TC were studied in batch experiments. The influence of the dosage of Fe3O4@G, the solution pH, and ion strength on the adsorption process were also assessed...
November 15, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27842965/influence-of-the-natural-colloids-on-the-multi-phase-distributions-of-antibiotics-in-the-surface-water-from-the-largest-lake-in-north-china
#20
Dengmiao Cheng, Xinhui Liu, Shengnan Zhao, Baoshan Cui, Junhong Bai, Zhaojun Li
Understanding antibiotic adsorption on natural colloids is crucial for prediction of the behavior, bioavailability and toxicity of antibiotics in natural waters. In the present study, the filtered water (dissolved phase, <0.7μm) was further separated into colloidal phase (1kDa-0.7μm) and soluble phase (<1kDa) by cross-flow ultrafiltration (CFUF), and the spatial-temporal variation and distribution of six antibiotics in multi-phases were investigated in Baiyangdian Lake. Results indicated that antibiotic concentrations differed significantly with sampling location and time...
November 11, 2016: Science of the Total Environment
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