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https://www.readbyqxmd.com/read/28524261/application-of-low-frequency-sonophoresis-and-reduction-of-antibiotics-in-the-aquatic-systems
#1
C Cobo Labarca, J Radinger, V Schöning, R Ariav, R Jung, K D Thompson, W Kloas, K Knopf
A major concern in aquaculture is the use of chemical therapeutics, such as antibiotics, because of their impact on the environment as well as on the fish product. As a potential tool for reducing antibiotic use, we tested the application of low-frequency ultrasound as a method for enhancing antibiotic uptake. Rainbow trout juveniles (Oncorhynchus mykiss) were exposed to two different concentrations of oxytetracycline (OTC), flumequine (FLU) and florfenicol (FLO), administered by bath after the application of ultrasound...
May 19, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28521601/significance-of-pregnancy-test-false-negative-results-due-to-elevated-levels-of-%C3%AE-core-fragment-hcg
#2
Sarah Johnson, Saji Eapen, Peter Smith, Graham Warren, Michael Zinaman
Very high levels of β-core fragment human chorionic gonadotrophin (βcf-hCG) are reported to potentially cause false negative results in point-of-care (POC)/over-the-counter (OTC) pregnancy tests. To investigate this further, women's daily early morning urine samples, collected prior to conception and during pregnancy, were analysed for intact, free β- and βcf-hCG. The proportion of βcf-hCG was found to be related to that of hCG produced and in circulation. Therefore, best practice for accuracy testing of POC/OTC pregnancy tests would be to test devices against clinical samples containing high levels of βcf-hCG as well as standards spiked with biologically relevant ratios...
May 19, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28521163/application-for-oxytetracycline-wastewater-pretreatment-by-fenton-iron-mud-based-cathodic-anodic-electrolysis-ceramic-granular-fillers
#3
Feilong Zhang, Qinyan Yue, Yuan Gao, Baoyu Gao, Xing Xu, Zhongfei Ren, Yang Jin
In this study, Fenton iron mud applied as main raw material of cathodic-anodic-electrolysis ceramic granular fillers (ICMF) in a continuous reactor, which were used to pretreat oxytetracycline (OTC) wastewater. The ICMF was characterized by Scanning Electron Microscope and Energy Dispersive Spectrometer analysis. The effects of pH value, hydraulic retention time, OTC concentrations and aeration on removal efficiency of total organic carbon (TOC) and OTC were studied. The degradation byproducts of OTC were analyzed by UV-2450, High Performance Liquid Chromatography and Liquid Chromatography-mass Spectrometry...
May 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28520392/gold-nanostar-enhanced-surface-plasmon-resonance-detection-of-an-antibiotic-at-attomolar-concentrations-via-an-aptamer-antibody-sandwich-assay
#4
Suhee Kim, Hye Jin Lee
A new sandwich assay for tetracycline (TC) involving a DNA aptamer and antibody pair is demonstrated in conjunction with gold nanostar (GNS) enhanced surface plasmon resonance (SPR) to achieve detection in the low attomolar range. GNS particles were covalently functionalized with the antibody probe (antiTC) and integrated into a surface sandwich assay in conjunction with a SPR gold chip modified with the TC-specific aptamer. After it was demonstrated that both affinity probes can bind simultaneously to TC, optimization of the assay was performed using either antiTC only or GNS-antiTC conjugates to interact with aptamer/TC complexes present on the chip surface...
May 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28513425/actual-use-of-and-adherence-to-ibuprofen-400%C3%A2-mg-tablet-dosing-instructions-in-a-simulated-otc-environment%C3%A2
#5
Suzanne Meeves, Rina Leyva, Clark Richardson, Brenda Wilson, David Savastano
OBJECTIVE: Evaluate adherence of US consumers to proposed label directions for a new 400 mg ibuprofen formulation. METHODS: In this single-arm, open-label, multicenter, 30-day study simulating an over-the-counter (OTC)-like environment, US analgesic consumers reviewed proposed product packaging for a new 400 mg ibuprofen formulation and made a purchase decision. Purchasers used the product as needed and recorded use over 30 days. Outcomes included the percentage of participants who exhibited correct or acceptable product use for the primary endpoint (not exceeding 1,200 mg/day > 2 times during the study) or secondary endpoint (not exceeding 400 mg/dose > 2 times during the study) and adherence to the labeled dosing interval of 6 - 8 hours...
May 17, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28512368/-analysis-of-the-phenomenon-of-over-the-counter-drug-abuse-and-not-controlled-herbs-trade-by-polish-adolescents-part-i
#6
REVIEW
Daria Suchecka, Jolanta Kucharska-Mazur, Katarzyna Groszewska, Monika Mak, Jerzy Samochowiec, Agnieszka Samochowiec
The phenomenon of stupefying by the use of available over-the-counter drugs (OTC) among adolescents is an essential problem in both Poland and throughout the world. Popular analgesics, cold medicine and antihistamines contain psychedelic substances, such as dextromethorphan (DXM), pseudoephedrine/ephedrine, codeine (methylmorphine), dimenhydrinate, paracetamol (acetaminophren) and others. Cases of fatal addiction to dextromethorphan, one of the active substances contained in medicines, e.g., the common cold, have been reported...
May 16, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28507991/evaluation-of-bioequivalence-of-two-long-acting-20-oxytetracycline-formulations-in-pigs
#7
Zhixin Lei, Qianying Liu, Bing Yang, Saeed Ahmed, Jincheng Xiong, Tingting Song, Pin Chen, Jiyue Cao, Qigai He
The aim of this study was to explore the bioequivalence of long-acting oxytetracycline in two formulations, a reference formulation (Terramycin 20% LA, Pfizer) and a test one (Kangtekang 20% LA, Huishen). Both formulations were administered intramuscularly at 20 mg/kg body weight at each of 24 healthy animals during a two-period crossover parallel experimental design. The oxytetracycline (OTC) concentrations in plasma were measured by high-performance liquid chromatography, and the limit of quantification was 0...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28506499/determination-of-butyltins-phenyltins-and-octyltins-in-foods-with-preservation-of-their-moieties-a-critical-review-on-analytical-methods
#8
REVIEW
Stephen W C Chung, Andy H T Wu
Tributyltin and triphenyltin have been extensively applied in anti-fouling paints since the 1960s. Hence, organotin compounds (OTCs), especially butyltins and phenyltins, in seafood has been of concern for decades. Even though the "International Convention on the Control of Harmful Anti-Fouling Systems on Ships, 2001" entered into force internationally in 2008 and prohibited the use of OTCs in anti-fouling paints used on ships, the analysis of OTCs in seafood was not commonly included in routine monitoring programmes...
May 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28503778/a-topical-zinc-ionophore-blocks-tumorigenic-progression-in-uv-exposed-skh-1-high-risk-mouse-skin
#9
Rebecca Justiniano, Jessica Perer, Anh Hua, Mohammad Fazel, Andrea Krajisnik, Christopher M Cabello, Georg T Wondrak
Nonmelanoma skin cancer (NMSC) is the most common malignancy in the United States representing a considerable public health burden. Pharmacological suppression of skin photo-carcinogenesis has shown promise in preclinical and clinical studies, but more efficacious photochemopreventive agents are needed. Here, we tested feasibility of harnessing pharmacological disruption of intracellular zinc-homeostasis for photochemoprevention in vitro and in vivo. Employing the zinc-ionophore and FDA-approved microbicidal agent zinc pyrithione (ZnPT), used worldwide in over-the-counter (OTC) topical consumer products, we first demonstrated feasibility of achieving ZnPT-based intracellular Zn(2+) -overload in cultured malignant keratinocytes (HaCaT-ras II-4; SCC-25) employing membrane-permeable fluorescent probes...
May 15, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28503226/consumer-views-on-safety-of-over-the-counter-drugs-preferred-retailers-and-information-sources-in-sweden-after-re-regulation-of-the-pharmacy-market
#10
Tommy Westerlund, Sahra Barzi, Cecilia Bernsten
BACKGROUND: The availability of over-the-counter drugs (OTCs) has increased in Sweden since a re-regulation of the pharmacy market in 2009, through which non-pharmacy retailers became permitted to provide certain OTCs. OBJECTIVE: To examine the adult general public's views on safety, purchasing and information channels, storage and disposal of OTCs in Sweden, three years after the re-regulation of the pharmacy market. METHODS: A questionnaire study in 2012-13 in a stratified, random sample of all inhabitants in Sweden ≥ 18 years old...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28503221/management-of-musculoskeletal-pain-in-retail-drug-outlets-within-a-nigerian-community-a-descriptive-study
#11
Samirah N Abdu-Aguye, Aishatu Shehu, Ubaidullah I Ahmad
OBJECTIVE: This work aimed to describe attitudes and practices of both community pharmacies and patent and proprietary medicine vendor (PPMV) outlets towards over-the-counter (OTC) analgesic use for musculoskeletal pain states within Zaria, Nigeria. METHODS: The study was carried out in 2 phases from May to August 2016. Phase one was a cross-sectional survey of 40 retail drug outlets (10 community pharmacies and 30 PPMVs). A simulated patient scenario of a young adult male complaining of acute onset back pain was used to collect data on the type and quality of analgesic recommended, duration of consultation, as well as nature of information provided during the drug dispensing process...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28500886/optimized-removal-of-oxytetracycline-and-cadmium-from-contaminated-waters-using-chemically-activated-and-pyrolyzed-biochars-from-forest-and-wood-processing-residues
#12
Aylin Aghababaei, Mohamed Chaker Ncibi, Mika Sillanpää
In the present investigation, the adsorptive removal of the antibiotic drug oxytetracycline (OTC) and toxic heavy metal cadmium (Cd) from aqueous solution was carried out using forest and wood-processing residues. Numerous biochars were prepared using different chemical agents (H3PO4, H2SO4, NaOH and KOH) and pyrolysis times and temperatures. Several elemental, chemical and structural characterizations were performed. The optimum conditions for pyrolysis to enable the production of biochars with well-developed porosity was 600°C for 1h, for both residues...
May 3, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28498043/pain-and-pain-management-among-university-students-online-survey-and-web-based-education
#13
Mimi Mun Yee Tse, Angel Tang, Andrea Budnick, Shamay Sheung Mei Ng, Suey Shuk Yu Yeung
Pain is common among university students. Unrelieved pain has adverse impacts on their quality of life. In this study, a pain management Web site was developed to distribute an online survey and provide Web-based pain education to university students. Participants were recruited from eight universities in Hong Kong using snowball sampling. The online survey included 37 items examining pain situations, pain management strategies, knowledge about self-medication, and demographic data of the participants. A total of 387 students participated and over 90 percent of them reported pain in the past 6 months...
May 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28497943/the-effects-of-over-the-counter-jaw-repositioning-mouthguards-on-aerobic-performance
#14
Devon L Golem, Patrick M Davitt, Shawn M Arent
BACKGROUND: Though jaw-repositioning devices have been found to increase size of upper respiratory airways in individuals, the effects of jaw-repositioning mouthguards on respiratory function during exercise have not been fully explored. The purpose of this study is to determine the effects of over-the-counter (OTC) jaw-repositioning mouthguards on respiratory function and aerobic performance in male athletes. METHODS: College-aged, male athletes (N.=20) participated in this randomized, crossover, controlled study...
June 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28466547/tele-pharmacy-in-rural-scotland-a-proof-of-concept-study
#15
Jackie Inch, Frances Notman, Margaret Watson, David Green, Robert Baird, James Ferguson, Caroline Hind, Brian McKinstry, Alison Strath, Christine Bond
INTRODUCTION: Technology enables medical services to be provided to rural communities. This proof of concept study assessed the feasibility and acceptability of delivering community pharmacy services (CPS; including advice, sale of over-the-counter products and dispensing of prescriptions) by tele-technology (the Telepharmacy Robotic Supply Service (TPRSS)) to a rural population in Scotland. METHODS: Data collection included the following: postal surveys to local residents; focus groups/ interviews with pharmacists, other healthcare professionals (HCPs) and service users, at baseline and follow-up; TPRSS logs...
June 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28462039/oxytetracycline-induces-dna-damage-and-epigenetic-changes-a-possible-risk-for-human-and-animal-health
#16
Adriana Gallo, Rosaria Landi, Valentina Rubino, Alessandro Di Cerbo, Angela Giovazzino, Anna Teresa Palatucci, Sara Centenaro, Gianandrea Guidetti, Sergio Canello, Laura Cortese, Giuseppina Ruggiero, Andrea Alessandrini, Giuseppe Terrazzano
BACKGROUND: Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity is relevant when considering the putative risk derived by the entry and accumulation of such drug in human and pet food chain supply. Despite scientific literature highlights several OTC-dependent toxic effects on human and animal health, the molecular mechanisms of such toxicity are still poorly understood...
2017: PeerJ
https://www.readbyqxmd.com/read/28456999/correlation-between-oral-fluid-and-plasma-oxytetracycline-concentrations-after-intramuscular-administration-in-pigs
#17
A Gajda, A Jablonski, M Gbylik-Sikorska, A Posyniak
The penetration of oxytetracycline (OTC) into the oral fluid and plasma of pigs and correlation between oral fluid and plasma were evaluated after a single intramuscular (i.m.) dose of 20 mg/kg body weight of long-acting formulation. The OTC was detectable both in oral fluid and plasma from 1 hr up to 21 day after drug administration. The maximum concentrations (Cmax ) of drug with values of 4021 ± 836 ng/ml in oral fluid and 4447 ± 735 ng/ml in plasma were reached (Tmax ) at 2 and 1 hr after drug administration respectively...
April 29, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28447018/predictors-of-over-the-counter-medication-a-cross-sectional-indian-study
#18
Abinash Panda, Supriya Pradhan, Gurukrushna Mohapatro, Jaya Singh Kshatri
CONTEXT: The determinants of over-the-counter (OTC) medication need to be understood to design adequate drug information policies. AIM: To determine the prevalence and predictors of OTC medication among the adult population of Berhampur town in Odisha, India. SETTINGS AND DESIGN: It was a prospective, cross-sectional, observational study carried out in the private retail pharmacy on a convenience sample of 880 adults over a period of 6 months at Berhampur, Odisha, India...
April 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28442898/medication-regimen-complexity-in-ambulatory-older-adults-with-heart-failure
#19
Michael R Cobretti, Robert L Page, Sunny A Linnebur, Kimberly M Deininger, Amrut V Ambardekar, JoAnn Lindenfeld, Christina L Aquilante
PURPOSE: Heart failure prevalence is increasing in older adults, and polypharmacy is a major problem in this population. We compared medication regimen complexity using the validated patient-level Medication Regimen Complexity Index (pMRCI) tool in "young-old" (60-74 years) versus "old-old" (75-89 years) patients with heart failure. We also compared pMRCI between patients with ischemic cardiomyopathy (ISCM) versus nonischemic cardiomyopathy (NISCM). PATIENTS AND METHODS: Medication lists were retrospectively abstracted from the electronic medical records of ambulatory patients aged 60-89 years with heart failure...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28434714/speed-resolution-advantage-of-turbulent-supercritical-fluid-chromatography-in-open-tubular-columns-ii-theoretical-and-experimental-evidences
#20
Fabrice Gritti, Michael Fogwill
The potential advantage of turbulent supercritical fluid chromatography (TSFC) in open tubular columns (OTC) was evaluated on both theoretical and practical viewpoints. First, the dispersion model derived by Golay in 1958 and recently extended from laminar to turbulent flow regime is used for the predictions of the speed-resolution performance in TSFC. The average dispersion coefficient of matter in the turbulent flow regime was taken from the available experimental data over a range of Reynolds number from 2000 to 6000...
April 19, 2017: Journal of Chromatography. A
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