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Carmela De Santo, Paul Cheng, Andrew Beggs, Sharon Egan, Alberto Bessudo, Francis Mussai
BACKGROUND: Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies to stimulate anti-cancer T cell responses, yet a number of patients will relapse and die of disease. Here, we report the first sustained complete remission in a patient with metastatic melanoma who failed two immunotherapy strategies, by targeting tumour arginine metabolism...
May 18, 2018: Journal of Hematology & Oncology
Heini Kari, Hanna Kortejärvi, Marja Airaksinen, Raisa Laaksonen
AIMS: The aim of this study is to evaluate how critical patient involvement is in pharmacist-led clinical medication reviews (CMRs) and in identifying the most significant clinical drug-related problems (DRPs). METHODS: Pharmacist-led CMRs were conducted with 161 consenting patients aged >75 years with 7+ prescribed medicines, living independently at home in Finland. A pharmacist, a nurse and a physician evaluated the clinical significance of the DRPs identified during the patient interview at an interprofessional case conference...
May 18, 2018: British Journal of Clinical Pharmacology
Meihua Hu, Pengcheng Huang, Lili Suo, Fangying Wu
A polydopamine-based molecularly imprinted polymer was deposited on the surface of magnetite (ferroferric oxide) nanoparticles (Fe3 O4 @PDA MIPs) and is shown to be an efficient and fairly specific sorbent for the extraction of various ochratoxins. The MIPs were characterized by IR spectroscopy and transmission electron microscopy. The adsorption capacities, evaluated through the langmuir adsorption isotherm model, are 1.8, 0.23 and 0.17 mg·g-1 for ochratoxin A, ochratoxin B and ochratoxin C, respectively...
May 15, 2018: Mikrochimica Acta
Aytekin Celik, Müslün Sara Tunc, Ozge Hanay, Ergin Taskan, Halil Hasar
In the recent years, there has been considerable debate about the potential impacts of antibiotics present in various environments on the public health and ecology. Oxytetracycline (OTC) is one of tetracycline antibiotic group used for growth and treatment of animals and humans. In this study, OTC and nitrate (NO3 -N) were simultaneously reduced using a hydrogen-based membrane biofilm reactor (H2 -MBfR). The system successfully accomplished OTC and nitrate removals. The fluxes of OTC and NO3 -N were 8.96 mg OTC/m2  day and 1100 mg N/m2  day, respectively...
May 15, 2018: Bioprocess and Biosystems Engineering
Jiwei Luo, Xue Li, Chengjun Ge, Karin Müller, Huamei Yu, Peng Huang, Jiatong Li, Daniel C W Tsang, Nanthi S Bolan, Jörg Rinklebe, Hailong Wang
Pollution of water by single antibiotics has been investigated in depth. However, in reality, a wide range of different contaminants is often mixed in the aquatic environment (contaminant cocktail). Here, single and competitive sorption dynamics of ionizable norfloxacin (NOR), sulfamerazine (SMR) and oxytetracycline (OTC) by both pristine and modified biochars were investigated. Sorption kinetics of the three antibiotics was faster in ternary-solute than single-solute system. Sorption efficiency was enhanced in the competitive system for NOR by the pristine biochar, and for OTC by both the pristine biochar and the modified biochar, while SMR sorption by the pristine biochar and the KOH-modified biochar was inhibited...
May 8, 2018: Bioresource Technology
Jorge Guzman-Lepe, Eduardo Cervantes-Alvarez, Alexandra Collin de l'Hortet, Yang Wang, Wendy M Mars, Yoshinao Oda, Yuki Bekki, Masahiro Shimokawa, Huanlin Wang, Tomoharu Yoshizumi, Yoshihiko Maehara, Aaron Bell, Ira J Fox, Kazuki Takeishi, Alejandro Soto-Gutierrez
The mechanisms by which the liver fails in end-stage liver disease remain elusive. Disruption of the transcription factor network in hepatocytes has been suggested to mediate terminal liver failure in animals. However, this hypothesis remains unexplored in human subjects. To study the relevance of transcription factor expression in terminal stages of chronic liver failure in humans, we analyzed the expression of liver-enriched transcription factors (LETFs) hepatocyte nuclear factor (HNF)4α, HNF1α, forkhead box protein A2 (FOXA2), CCAAT/enhancer-binding protein (CEBP)α, and CEBPβ...
May 2018: Hepatology Communications
Yalda Shoja, Ahmad Kermanpur, Fathallah Karimzadeh
In this present work we made a novel, fast, selective and sensitive electrochemical genobiosensor to detection of EGFR exon 21 point mutation based on two step electropolymerization of Ni(II)-oxytetracycline conducting metallopolymer nanoparticles (Ni-OTC NPs) on the surface of pencil graphite electrode (PGE) which was modified by reduced graphene oxide/carboxyl functionalized ordered mesoporous carbon (rGO/f-OMC) nanocomposite. ssDNA capture probe with amine groups at the5' end which applied as recognition element was immobilized on the rGO/f-OMC/PGE surface via the strong amide bond...
April 14, 2018: Biosensors & Bioelectronics
Zi Juan Liu, Zong Peng Yang, Ping Li, Yu Zheng Zong, Qi Dong, Xing Yu Hao
We used an OTC (open top chamber) system to study the effects of elevated CO2 concentration (atmospheric CO2 concentration + 200 #x03BC;mol·mol-1 ) on the growth and photosynthetic physiology of Hylotelephium erythrostictum. Elevated CO2 concentration decreased the leaf stomatal density of the upper and lower epidermis of H. erythrostictum by 16.1% and 16.7%, respectively. Elevated CO2 concentration increased the vascular bundle in leaves and the cell volume near the upper epidermis. Elevated CO2 concentration significantly increased the photosynthetic pigments content, net photosynthetic rate, stomatal conductance and transpiration rate of H...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Yue Xi Chen, Bei Chen, Hui Sun, Li Hong Ma, Dan Jie Shen, Yan Yang Liu
The decomposition dynamics of organic components in fresh litter of Larix potaninii were monitored by in situ litter-bag incubation under four treatments, i.e., field condition (CK), nitrogen addition (AN, 2 g N·m-2 ), warming by top-open chamber (OTC), nitrogen addition with warming by top-open chamber (OTC+AN), from November to next September. Decomposition of water-soluble sugar, water-soluble phenol and total polyphenol were stimulated significantly under the treatment OTC, AN and OTC+AN during the first four months compared with the CK, but the difference of these components release narrowed with the extension of incubation time...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Theodor Alexandru Voiosu, Andrada Viorela Gheorghe, Dan Adrian Bobeica, Andrei Mihai Voiosu, Radu Bogdan Mateescu
Tracheoesophageal fistula (TEF) is frequently congenital and requires surgical correction. TEF can also occur secondary to malignant esophageal tumors or benign diseases and these cases are managed by endoscopic means, such as closing the defect with metallic stents. Although esophageal injury can occur secondary to nonsteroidal anti-inflammatory drugs (NSAIDs), TEF secondary to chronic NSAIDs use hasn't been described in the literature. We report the case of a male patient with refractory migraine and chronic use of NSAIDs, with a history of esophageal stenosis presenting with acute-onset total dysphagia...
May 8, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Ana Lb Jurema, Evaniele S Claudino, Carlos Rg Torres, Eduardo Bresciani, Taciana Mf Caneppele
Aim: The purpose of this in vitro study was to evaluate the color and microhardness of teeth subjected to different over-the-counter (OTC) whitening products in association or not with 10% carbamide peroxide (10% CP). Materials and methods: Enamel-dentin specimens (n = 210) were obtained from bovine incisors and stained. Half of the specimens were then subjected to daily cycles of staining (5 minutes), 10% CP bleaching (8 hours) in association with OTC products, and artificial saliva storage until complete 24 hours, for 2 weeks; the other half was subjected to daily cycles of staining, OTC treatment, and storage in artificial saliva for 12 weeks...
April 1, 2018: Journal of Contemporary Dental Practice
Yiran Rong, Lori M Ward, Seena Haines, Meagen Rosenthal
BACKGROUND: Community pharmacists-directed weight management programs have demonstrated positive impacts. OBJECTIVE: To explore the feasibility of developing a community pharmacy-based weight management program by examining pharmacists' perceptions of the implementation of such a program in their practice setting. METHODS: This study employed a cross-sectional online survey design. The respondents were registered community pharmacists in the southeastern United States...
January 1, 2018: Journal of Pharmacy Practice
Iván Chérrez-Ojeda, Juan Carlos Calderón, Erick Calero, César Terán, Annia Chérrez
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID)-induced hypersensitivity reactions can be clinically apparent with asthma, rhinosinusitis, anaphylaxis or rash. Although natural anti-inflammatory products can have similar components, they are not subjected to rigorous quality control standards. CASE REPORT: The case is presented of a 22-year-old female with NSAID allergy who attended with facial and laryngeal angioedema associated with pruritus in eyelids and pharynx...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Archana Raghavan, Yoshita Paliwal, Patricia W Slattum
As the number of available over-the-counter (OTC) products increases, many older adults are taking health care into their own hands. It is particularly important that the labeling provided with these products is precise, leading to their effective use, especially by older adults. Suboptimally designed medication labels can increase the risk of consumption errors and adverse drug interactions among seniors. This study evaluated whether the warning labels on potentially inappropriate OTC medications are consistent with evidencebased criteria for potentially inappropriate prescribing in older adults...
March 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Vivien Tong, David K Raynor, Parisa Aslani
BACKGROUND: Limited research has evaluated the consumer usability of written information available with similar over-the-counter (OTC) products in different countries. This study evaluated the usability of labels and leaflets for Australian and UK OTC diclofenac products and explored consumer perspectives on their design, content, usability, and potential improvements. METHODS: Australian and UK OTC diclofenac products were selected for user testing. Demographically matched groups of Australian and UK consumers were recruited to user test each label and leaflet set to determine whether 9 salient clinical messages could be found and understood...
January 2018: Therapeutic Innovation & Regulatory Science
Chi-Ming Tu
BACKGROUND: To identify if proprietary names are used by health care practitioners when prescribing over-the-counter (OTC) drug products. These findings can inform evaluation of proposed proprietary names for both prescription and OTC drug products. METHODS: QuintilesIMS OTC International Market Tracking (QuintilesIMS OTCIMS) was used to identify top OTC drug products sold to the consumers from US retail store outlets in year 2011. QuintilesIMS's Vector One: National (VONA) was used to identify prescribers' use of proprietary names by examining drug use data from 2003 to 2011 for the top OTC products identified from QuintilesIMS OTCIMS...
January 1, 2018: Therapeutic Innovation & Regulatory Science
Maria Majsnerowska, Elke E E Noens, Juke S Lolkema
High concentrations of L-arginine or L-citrulline in the growth medium provided the wine bacterium Lactobacillus brevis with a significant growth advantage. The arginine deiminase pathway (ADI) arc gene cluster of Lb. brevis contains three genes, arcD, arcE1 and arcE2, encoding putative L-arginine/L-ornithine exchangers. Uptake experiments with Lactococcus lactis cells expressing the genes showed that all three transported L-ornithine with affinities in the μM range. Similarly, ArcD and ArcE2 transported L-arginine, while ArcE1 transported L-citrulline, an intermediate of the ADI pathway...
April 30, 2018: Journal of Bacteriology
M Conde-Cid, D Fernández-Calviño, J C Nóvoa-Muñoz, M Arias-Estévez, M Díaz-Raviña, M J Fernández-Sanjurjo, A Núñez-Delgado, E Álvarez-Rodríguez
Veterinary antibiotics reaching soils and water bodies are considered emerging pollutants deserving special attention. In this work, dissipation of tetracycline (TC), oxytetracycline (OTC) and chlortetracycline (CTC) is investigated. Dissipation experiments in filtered water, using simulated sunlight, resulted in the following degradation sequence: TC < OTC ≈ CTC, with half-life values of 229, 101 and 104 min, respectively; however, no dissipation took place in the dark. Dissipation of the three tetracyclines in culture medium and with simulated sunlight was much higher, giving the sequence TC ≈ OTC < CTC, with half-lives of 9, 10 and 7 min, respectively; in the dark, TC and OTC did not suffer dissipation, but it was around 28% for CTC at the end of the experiment (480 min)...
April 25, 2018: Science of the Total Environment
Qin Ping, Sheng Xu, Wei Chen, Xing Yuan He, Yan Qing Huang, Xian Wu
Taking ambient environmental O3 (40 nmol·mol-1 ) as control, the study was conducted to assess the impact of elevated O3 (80 and 160 nmol·mol-1 ) on the growth, subcellular structure and reactive oxygen metabolism of turf-type Festuca arundinace in open top-chambers (OTCs). The results showed that under 14-day fumigation, the height and leaf width of F. arundinace decreased significantly, and the total biomass decreased by 43.7%, and some fully expanded leaves yellowed under 80 nmol·mol-1 O3 . Some visible injury symptoms, brown spots and necrosis appeared in the leaves, the total biomass decreased by 46...
December 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Joshua Eloge, T Celeste Napier, Bezalel Dantz
Substance Use Disorders (SUDs) are pervasive in the United States, with 20.1 million cases in 2016, of which only 19% receive treatment. SUDs permeate all medical specialties and should be considered in the differential diagnosis of every chief complaint. Acknowledging the salience of SUDs provides a unique opportunity for early identification and intervention. Thus, SUDs should be reflected prominently in the History of the Present Illness rather than in the Social History. To this effect, we propose the inclusion of Use (U) in the History of Present Illness, and incorporating "U" into the pedagogical mnemonic of OPQRST that is commonly used in medical training...
April 25, 2018: Substance Abuse
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