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https://www.readbyqxmd.com/read/28326769/octadecyltrichlorosilane-deposition-on-mica-surfaces-the-insight-interface-interaction-mechanism
#1
Jun Huang, Xiaokong Liu, Xiaoyong Qiu, Lei Xie, Bin Yan, Xiaogang Wang, Qingxue Huang, Hongbo Zeng
Surface functionalization by alkylsilanes has been widely used in many engineering applications. In this work, a systematic investigation was conducted on the deposition behaviors of octadecyltrichlorosilane (OTCS) on freshly cleaved mica surfaces that possess low density of reactive sites (i.e., silanol groups) via a vapor deposition method. The deposition of OTCS molecules on mica was found to follow a two-stage process, as monitored by measuring the surface morphology using atomic force microscope (AFM) and wettability of the samples obtained at different deposition times...
March 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28325852/extended-multiplexing-of-tmt-labeling-reveals-age-and-high-fat-diet-specific-proteome-changes-in-mouse-epididymal-adipose-tissue
#2
Deanna L Plubell, Phillip A Wilmarth, Yuqi Zhao, Alexandra M Fenton, Jessica Minnier, Ashok P Reddy, John Klimek, Xia Yang, Larry L David, Nathalie Pamir
The lack of high-throughput methods to analyze the adipose tissue protein composition limits our understanding of the protein networks responsible for age and diet related metabolic response. We have developed an approach using multiple-dimension liquid chromatography tandem mass spectrometry and extended multiplexing (24 biological samples) with TMT labeling to analyze proteomes of epididymal adipose tissues isolated from mice fed either low or high fat diet for a short or a long-term, and from mice that aged on low vs...
March 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28318700/effects-of-warming-and-nitrogen-deposition-on-ch4-co2-and-n2o-emissions-in-alpine-grassland-ecosystems-of-the-qinghai-tibetan-plateau
#3
Zhenzhen Zhao, Shikui Dong, Xiaoman Jiang, Shiliang Liu, Hanzhong Ji, Yu Li, Yuhui Han, Wei Sha
Increases in nitrogen (N) deposition along with climate warming can change the dynamics of carbon and nitrogen in the soil, and alter greenhouse gases (GHGs) fluxes. To examine how N deposition and warming affect GHGs (CH4, CO2 and N2O) fluxes in alpine grasslands, we conducted experiments in an alpine meadow (AM), alpine-steppe (AS), and alpine cultivated grassland (CG) on the Qinghai-Tibetan Plateau (QTP). We simulated N deposition by treating soil with ammonium nitrate (NH4NO3) (8kgNha(-1)year(-1)), a warming treatment using an open top chamber (OTC) was carried out, and a combined treatment of warming and N deposition (8kgNha(-1)year(-1)) was conducted...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28317327/a-research-agenda-for-moving-early-medical-pregnancy-termination-over-the-counter
#4
REVIEW
Nathalie Kapp, Daniel Grossman, Emily Jackson, Laura Castleman, Dalia Brahmi
Given the overall safety profile and increasing availability of medical pregnancy termination drugs, we asked: would the mifepristone-misoprostol regimen for medical termination at ≤10 weeks gestation meet U.S. FDA regulatory criteria for over-the-counter (OTC) approval, and if not, what are the present research gaps? We conducted a literature review of consumer behaviors necessary for a successful OTC application for medical termination ≤10 weeks and identified crucial research gaps. If we were to embark on a development program for OTC or more generally, self-use of medical termination, the critical elements missing are the label comprehension, self -selection and actual use studies...
March 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28315470/the-nitric-oxide-synthase-2-pathway-is-targeted-by-both-pro-and-anti-inflammatory-treatments-in-the-immature-human-intestine
#5
Emanuela Ferretti, Eric Tremblay, Marie-Pier Thibault, David Grynspan, Karolina M Burghardt, Marcos Bettolli, Corentin Babakissa, Emile Levy, Jean-François Beaulieu
BACKGROUND AND AIM: NO synthase 2 (NOS2) was recently identified as one the most overexpressed genes in intestinal samples of premature infants with necrotizing enterocolitis (NEC). NOS2 is widely implicated in the processes of epithelial cell injury/apoptosis and host immune defense but its specific role in inflammation of the immature human intestinal mucosa remains unclear. Interestingly, factors that prevent NEC such as epidermal growth factor (EGF) attenuate the inflammatory response in the mid-gestation human small intestine using serum-free organ culture while drugs that are associated with NEC occurrence such as the non-steroidal anti-inflammatory drug, indomethacin (INDO), exert multiple detrimental effects on the immature human intestine...
March 14, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28314704/over-the-counter-access-to-oral-contraceptives-for-adolescents
#6
REVIEW
Krishna K Upadhya, John S Santelli, Tina R Raine-Bennett, Melissa J Kottke, Daniel Grossman
Oral contraceptives (OCs) are used by millions of women in the U.S. The requirement to obtain OCs by prescription from a clinician may serve as a barrier to contraceptive initiation and continuation for women, in particular adolescents. Over-the-counter (OTC) availability would reduce this barrier and could further reduce unintended pregnancy rates. This review explores the scientific issues and regulatory processes involved in switching OCs to OTC status for minor adolescents. We review: (1) the regulatory criteria for switching a drug to OTC status; (2) risk of pregnancy and safety during use of OCs including combined oral contraceptives and progestin-only pills for adolescents; (3) the ability of adolescents to use OCs consistently and correctly; (4) OTC access to OCs and potential effect on sexual risk behaviors; and (5) the potential for reduced opportunities for clinicians to counsel and provide recommended reproductive health care to adolescents...
March 6, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28291385/determination-of-oxytetracycline-and-4-epi-oxytetracycline-residues-in-feathers-and-edible-tissues-of-broiler-chickens-using-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#7
Javiera Cornejo, Ekaterina Pokrant, Magdalena Krogh, Cristóbal Briceño, Héctor Hidalgo, Aldo Maddaleno, Carolina Araya-Jordán, Betty San Martín
Antibiotics have been widely used in poultry production for the treatment of bacterial diseases. However, drug residues can remain in products derived from animals after the cessation of the drug therapies. Feathers, in particular, have shown an affinity for antibiotics such as tetracycline, suggesting the persistence of these drugs in nonedible tissue. After the birds are slaughtered, feathers are ground into feather meals, which are used as organic fertilizer or an ingredient in animal diets, thereby entering into the food chain and becoming a potential risk for public health...
March 14, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28284554/effects-of-biochar-on-reducing-the-abundance-of-oxytetracycline-antibiotic-resistance-genes-and-human-pathogenic-bacteria-in-soil-and-lettuce
#8
Manli Duan, Haichao Li, Jie Gu, Xiaxia Tuo, Wei Sun, Xun Qian, Xiaojuan Wang
Antibiotics and antibiotic resistance genes (ARGs) in soil can affect human health via the food chain. Biochar is a soil amendment but its impacts on ARGs and the microbial communities associated with soil and vegetables are unclear. Therefore, we established three lettuce pot culture experiments, i.e., O300: 300 mg/kg oxytetracycline (OTC), BO300: 300 mg/kg OTC + 2% biochar, and a control without OTC or biochar. We found that under BO300, the relative abundances of ARGs were reduced by 51.8%, 43.4%, and 44...
March 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28283499/metabolite-identification-reaction-phenotyping-and-retrospective-drug-drug-interaction-predictions-of-17-deacetylnorgestimate-the-active-component-of-the-oral-contraceptive-norgestimate
#9
Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar, Murali Subramanian
Ortho-Tri-Cyclen® (OTC), a two drug cocktail comprising of ethinylestradiol (EE) and norgestimate (13-ethyl-17-acetoxy-18, 19-dinor-17α-pregn-4-en-20yn-3 oxime), is commonly prescribed to avert unwanted pregnancies in women of reproductive age. In vivo, norgestimate undergoes extensive and rapid deacetylation to produce 17-deacetylnorgestimate (NGMN), an active circulating metabolite that likely contributes significantly to norgestimate efficacy. Despite being of primary significance, the metabolism and reaction phenotyping of NGMN have not been previously reported...
March 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28283349/aav-gene-therapy-corrects-otc-deficiency-and-prevents-liver-fibrosis-in-aged-otc-knock-out-heterozygous-mice
#10
Lili Wang, Peter Bell, Hiroki Morizono, Zhenning He, Elena Pumbo, Hongwei Yu, John White, Mark L Batshaw, James M Wilson
Ornithine transcarbamylase (OTC) deficiency is an X-linked disorder of the urea cycle. Hemizygous males and heterozygous females may experience life-threatening elevations of ammonia in blood and brain, leading to irreversible cognitive impairment, coma, and death. Recent evidence of acute liver failure and fibrosis/cirrhosis is also emerging in OTC-deficient patients. Here, we investigated the long-term consequences of abnormal ureagenesis in female mice heterozygous (Het) for a null mutation in the OTC gene...
March 2, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28281571/a-de-novo-nonsense-mutation-in-magel2-in-a-patient-initially-diagnosed-as-opitz-c-similarities-between-schaaf-yang-and-opitz-c-syndromes
#11
Roser Urreizti, Anna Maria Cueto-Gonzalez, Héctor Franco-Valls, Sílvia Mort-Farre, Neus Roca-Ayats, Julia Ponomarenko, Luca Cozzuto, Carlos Company, Mattia Bosio, Stephan Ossowski, Magda Montfort, Jochen Hecht, Eduardo F Tizzano, Bru Cormand, Lluïsa Vilageliu, John M Opitz, Giovanni Neri, Daniel Grinberg, Susana Balcells
Opitz trigonocephaly C syndrome (OTCS) is a rare genetic disorder characterized by craniofacial anomalies, variable intellectual and psychomotor disability, and variable cardiac defects with a high mortality rate. Different patterns of inheritance and genetic heterogeneity are known in this syndrome. Whole exome and genome sequencing of a 19-year-old girl (P7), initially diagnosed with OTCS, revealed a de novo nonsense mutation, p.Q638*, in the MAGEL2 gene. MAGEL2 is an imprinted, maternally silenced, gene located at 15q11-13, within the Prader-Willi region...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28280312/self-medication-practice-in-ethiopia-a-systematic-review
#12
REVIEW
Mohammed Biset Ayalew
BACKGROUND: Self-medication patterns vary among different populations, and are influenced by many factors. No review has been done that comprehensively expresses self-medication practice in Ethiopia. The aim of this study was to provide an overview of the literature on self-medication practice in Ethiopia. MATERIALS AND METHODS: Databases (PubMed, Google Scholar, ResearchGate, and Hinari) were searched for published studies on the practice of self-medication in Ethiopia without restriction in the year of publication or methodology...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28277131/macro-regional-variation-in-attitudes-toward-and-experiences-of-vulvar-and-vaginal-atrophy-among-italian-post-menopausal-women-a-post-hoc-analysis-of-revive-survey-data
#13
Rossella E Nappi, Martire Particco, Nicoletta Biglia, Angelo Cagnacci, Costantino Di Carlo, Stefano Luisi, Anna Maria Paoletti
Italian participants in the European REVIVE survey reported that vaginal and vulvar atrophy (VVA) impaired various aspects of their lives, notably the ability to enjoy sex. The aim of the present study was to explore regional differences in knowledge, experiences, and treatment of VVA in the Italian REVIVE sample (n = 1000), which was analyzed according to region of residence. While many respondents were unfamiliar with the VVA condition, most could relate their VVA symptoms to the menopause. The rate of diagnosis of VVA was twice as high in Central Italy as in the North-East...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28272051/chemical-adsorption-of-oxytetracycline-from-aqueous-solution-by-modified-molecular-sieves
#14
Junmin Lv, Yulong Ma, Xuan Chang, Junzhuo Fang, Lingyan Cai, Yan Ma, Subing Fan
The removal of oxytetracycline (OTC) from aqueous solution on modified molecular sieve via adsorption was investigated in the present work. The copper(II) modified molecular sieve had the much higher adsorbed amount than unmodified one. The bigger pore, the more adsorption sites benefitted for the adsorbed amount of OTC. The exchanged amount of copper(II) and the acid-base property of solution were important factors influencing the removal efficiency. The adsorption kinetics, the adsorption isotherm, the adsorption thermodynamics and the proposed adsorption mechanism were studied...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28270654/a-proposed-physiopathological-pathway-to-hyperammonemic-encephalopathy-in-a-non-cirrhotic-patient-with-fibrolamellar-hepatocellular-carcinoma-without-ornithine-transcarbamylase-otc-mutation
#15
Rodrigo C Surjan, Elizabeth S Dos Santos, Tiago Basseres, Fabio F Makdissi, Marcel A Machado
BACKGROUND Hyperammonemic encephalopathy is a potentially fatal condition that may progress to irreversible neuronal damage and is usually associated with liver failure or portosystemic shunting. However, other less common conditions can lead to hyperammonemia in adults, such as fibrolamellar hepatocellular carcinoma. Clinical awareness of hyperammonemic encephalopathy in patients with normal liver function is paramount to timely diagnosis, but understanding the underlying physiopathology is decisive to initiate adequate treatment for complete recovery...
March 8, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28267999/extension-of-golay-s-plate-height-equation-from-laminar-to-turbulent-flow-i-theory
#16
Fabrice Gritti
The reduced plate height (RPH) equation of Golay derived in 1958 for open tubular columns (OTC) is extended from laminar to turbulent-like flow. The mass balance equation is solved under near-equilibrium conditions in the mobile phase for changing shapes of the velocity profile across the OTC diameter. The final expression of the general RPH equation is: [Formula: see text] where ν is the reduced linear velocity, k is the retention factor, Dm is the bulk diffusion coefficient in the mobile phase, Da¯ is the average axial dispersion coefficient, Dr¯ is the average radial dispersion coefficient, Ds is the diffusion coefficient of the analyte in the stationary film of thickness df, D is the OTC inner diameter, and n≥2 is a positive number controlling the shape of the flow profile (polynomial of degree n)...
February 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28261508/urea-cycle-defects-early-onset-disease-associated-with-a208t-mutation-in-otc-gene-expanding-the-clinical-phenotype
#17
Ana Isabel Sánchez, Alejandra Rincón, Mary García, Fernando Suárez-Obando
Ornithine transcarbamylase deficiency (OMIM: 311250) is the most common disorder of urea cycle disorders, accounting for nearly 50% of all cases. We report a case of a two-month- old male patient, who attends our medical genetics consultation because of low citrulline levels and elevated glutamine to citrulline ratio detected by expanded newborn screening with tandem mass spectrometry. He is an asymptomatic male with a normal physical examination and appropriate neurodevelopmental milestones. The patient has a family history of one older brother who died at 18 months old from severe and sudden hyperammonemia and a maternal aunt who suddenly died at two years old...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28256620/time-lapse-imaging-reveals-highly-dynamic-structural-maturation-of-postnatally-born-dentate-granule-cells-in-organotypic-entorhino-hippocampal-slice-cultures
#18
Tijana Radic, Tassilo Jungenitz, Mathias Singer, Marcel Beining, Hermann Cuntz, Andreas Vlachos, Thomas Deller, Stephan W Schwarzacher
Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and is important for learning and memory. How newborn GCs differentiate and mature into an existing circuit during this time period is not yet fully understood. We established a method to visualize postnatally generated GCs in organotypic entorhino-hippocampal slice cultures (OTCs) using retroviral (RV) GFP-labeling and performed time-lapse imaging to study their morphological development in vitro. Using anterograde tracing we could, furthermore, demonstrate that the postnatally generated GCs in OTCs, similar to adult born GCs, grow into an existing entorhino-dentate circuitry...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28252160/the-effects-of-service-delivery-model-and-purchase-price-on-hearing-aid-outcomes-in-older-adults-a-randomized-double-blind-placebo-controlled-clinical-trial
#19
Larry E Humes, Sara E Rogers, Tera M Quigley, Anna K Main, Dana L Kinney, Christine Herring
Objectives: The objectives of this study were to determine efficacy of hearing aids in older adults using audiology best practices, to evaluate the efficacy of an alternative over-the-counter (OTC) intervention, and to examine the influence of purchase price on outcomes for both service-delivery models. Design: The design of this study was a single-site, prospective, double-blind placebo-controlled randomized trial with three parallel branches: (a) audiology best practices (AB), (b) consumer decides OTC model (CD), and (c) placebo devices (P)...
March 2, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28246309/ovarian-fragment-sizes-affect-viability-and-morphology-of-preantral-follicles-during-storage-at-4%C3%A2%C2%BAc
#20
Gustavo Desire Antunes Gastal, Benner G Alves, Kele Amaral Alves, Maria Eduarda Magalhães Souza, Arnaldo Diniz Vieira, Antonio Sergio Varela Junior, José Ricardo Figueiredo, Jean Feugang, Thomaz Lucia Junior, Eduardo L Gastal
The method of transportation and the conditions imposed on the ovarian tissue are pivotal aspects for the success of ovarian tissue cryopreservation (OTC). The aim of this study was to evaluate the effect of the size of the ovarian tissue (e.g., whole ovary, biopsy size, and transplant size) during different times of storage (0, 6, 12, and 24 h) on the structural integrity of equine ovarian tissue transported at 4°C. Eighteen pairs of ovaries from young mares (<10 years old) were harvested in a slaughterhouse and processed to simulate the fragment sizes (biopsy and transplant size groups) or kept intact (whole ovary group), and stored at 4°C for up to 24 h in α-MEM enriched solution...
February 28, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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