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Tosoni Annalisa, Guidotti Roberto, Del Gratta Cosimo, Committeri Giorgia, Sestieri Carlo
The human ventral occipito-temporal cortex (OTC) contains areas specialized for particular perceptual/semantic categories, such as faces (fusiform face area, FFA) and places (parahippocampal place area, PPA). This organization has been interpreted as reflecting the visual structure of the world, i.e. perceptual similarity and/or eccentricity biases. However, recent functional magnetic resonance imaging (fMRI) studies have shown not only that regions of the OTC are modulated by non-visual, action-related object properties but also by motor planning and execution, although the functional role and specificity of this motor-related activity are still unclear...
October 15, 2016: Neuropsychologia
Kendra Thomsen, Kim Zuber, Jane Davis, Greg Thomas
OBJECTIVE: Kidneys in a Box (KIB) was developed to identify the effect of a performance improvement CME (PI-CME) project on the management of patients with diabetes who are at risk for chronic kidney disease (CKD). The program provided nonnephrology practitioners with research-based interventions known to slow CKD progression. METHODS: PAs were given the KIB tool kit, which described the scope of CKD identified high-risk diagnoses such as diabetes, and listed six modifiable risk factors that have been shown to slow progression of diabetic kidney disease when implemented...
October 5, 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
Ruby Upadhyay, Thomas P Bleck, Katharina M Busl
Purpose. A 66-year-old man who presented with coma was found to have isolated severe hyperammonemia and diagnosed with a late-onset urea-cycle disorder. He was treated successfully and had full recovery. Methods. We report a novel case of noncirrhotic hyperammonemia and review the literature on this topic. Selected literature for review included English-language articles concerning hyperammonemia using the search terms "hyperammonemic encephalopathy", "non-cirrhotic encephalopathy", "hepatic encephalopathy", "urea-cycle disorders", "ornithine transcarbamylase (OTC) deficiency", and "fulminant hepatic failure"...
2016: Case Reports in Medicine
Ian M Paul, Kate M Reynolds, Ralph E Kauffman, William Banner, G Randall Bond, Robert B Palmer, Randy I Burnham, Jody L Green
STUDY OBJECTIVE: Dextromethorphan is the most common over-the-counter (OTC) antitussive medication. We sought to characterize adverse events associated with dextromethorphan in children <12 years old from a surveillance program of OTC cough/cold medication exposures. METHODS: This is a retrospective case series of oral exposures to dextromethorphan with ≥1 adverse event from multiple U.S. sources (National Poison Data System, FDA Adverse Event Reporting System, manufacturer safety reports, news/media, medical literature) reported between 2008 and 2014...
October 13, 2016: Clinical Toxicology
Victoria Grèze, Florence Brugnon, Fanny Chambon, Pascale Halle, Michel Canis, Clotilde Amiot, Anne-Sophie Grémeau, Bruno Pereira, Yania Yáñez Peralta, Andrei Tchirkov, Justyna Kanold
BACKGROUND: Ovarian tissue cryopreservation (OTC) is the only option available to preserve fertility in prepubertal females with neuroblastoma (NB), a childhood solid tumor that can spread to the ovaries, with a risk of reintroducing malignant cells after an ovarian graft. PROCEDURE: We set out to determine whether the analysis of TH (tyrosine hydroxylase), PHOX2B (paired-like homeobox 2b), and DCX (doublecortin) transcripts using quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) could be used to detect NB contamination in ovarian tissue...
October 12, 2016: Pediatric Blood & Cancer
Yuko Wada, Yukie Takaoka, Mitsuru Nozawa, Miho Goto, Ken-Ichi Shimokawa, Fumiyoshi Ishii
We measured the pH, water-vapor permeability, adhesive force, peeling-force, elongation rate, support flexibility, and peeling time of medicinal and over-the-counter (OTC) tape preparations containing felbinac. When measuring the pH of each preparation, Felnabion (pH 4.5) was weakly acidic, and EMEC and Tokuon (pH 7.0) were neutral. When measuring the water-vapor permeability of each preparation, that of a generic product, EMEC (380 g/m(2)/24h), was twice as high as that of a brand-name product, Seltouch (189 g/m(2)/24 h)...
October 4, 2016: Drug Discoveries & Therapeutics
Meryam El Issaoui, Veronica Giorgione, Linn S Mamsen, Catherine Rechnitzer, Niels Birkebæk, Niels Clausen, Thomas W Kelsey, Claus Yding Andersen
OBJECTIVE: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse. DESIGN: Retrospective case-control study. SETTING: University hospitals. PATIENT(S): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment...
October 4, 2016: Fertility and Sterility
Kristina M Brooks, Jomy M George, Parag Kumar
Use of complementary and alternative medicines (CAMs) and over-the-counter (OTC) medications are very common among HIV-infected patients. These products can cause clinically significant drug-drug interactions (DDIs) with antiretroviral (ARV) medications, thereby increasing risk for negative outcomes such as toxicity or loss of virologic control. Areas Covered: This article provides an updated review of the different mechanisms by which CAM and OTC products are implicated in DDIs with ARV medications. Expert Commentary: Much of the literature published to date involves studies of CAMs interacting with older ARV agents via the cytochrome P450 (CYP450) system...
October 7, 2016: Expert Review of Clinical Pharmacology
Shouliang Yin, Zilong Li, Xuefeng Wang, Huizhuan Wang, Xiaole Jia, Guomin Ai, Zishang Bai, Mingxin Shi, Fang Yuan, Tiejun Liu, Weishan Wang, Keqian Yang
Heterologous expression is an important strategy to activate biosynthetic gene clusters of secondary metabolites. Here, it is employed to activate and manipulate the oxytetracycline (OTC) gene cluster and to alter OTC fermentation process. To achieve these goals, a fast-growing heterologous host Streptomyces venezuelae WVR2006 was rationally selected among several potential hosts. It shows rapid and dispersed growth and intrinsic high resistance to OTC. By manipulating the expression of two cluster-situated regulators (CSR) OtcR and OtrR and precursor supply, the OTC production level was significantly increased in this heterologous host from 75 to 431 mg/l only in 48 h, a level comparable to the native producer Streptomyces rimosus M4018 in 8 days...
October 5, 2016: Applied Microbiology and Biotechnology
Tingting Ma, Liqiang Zhou, Li 'ke Chen, Zhu Li, Longhua Wu, Peter Christie, Yongming Luo
Excessive use of antibiotics potentially threatens human health, agricultural production and soil phytoremediation. This arouses concern over the potential adverse effects of a commonly used antibiotic, oxytetracycline (OTC), on plants used for soil remediation and possible stimulation of antibiotic resistance genes in soils. A greenhouse experiment was conducted to investigate different rates (0, 1, 5, and 25 mg kg-1) and frequencies (one single high and daily low application) of OTC addition to soil on phytoremediation of a heavy metal contaminated soil by Sedum plumbizincicola and/or Medicago sativa (alfalfa)...
October 5, 2016: Journal of Agricultural and Food Chemistry
Huixiao Hong, Diego Rua, Sugunadevi Sakkiah, Chandrabose Selvaraj, Weigong Ge, Weida Tong
Sunscreen products are predominantly regulated as over-the-counter (OTC) drugs by the US FDA. The "active" ingredients function as ultraviolet filters. Once a sunscreen product is generally recognized as safe and effective (GRASE) via an OTC drug review process, new formulations using these ingredients do not require FDA review and approval, however, the majority of ingredients have never been tested to uncover any potential endocrine activity and their ability to interact with the estrogen receptor (ER) is unknown, despite the fact that this is a very extensively studied target related to endocrine activity...
2016: International Journal of Environmental Research and Public Health
Glen J Nowak, Michael A Cacciatore
There has been significant and growing interest in vaccine hesitancy and confidence in the United States as well as across the globe. While studies have used confidence measures, few studies have provided in-depth assessments and no studies have assessed parents' confidence in vaccines in relationship to other frequently recommended health-related products for young children. This study used a nationally representative sample of 1000 U.S. parents to identify confidence levels for recommended vaccinations, antibiotics, over-the-counter (OTC) medicines, and vitamins for children...
September 28, 2016: Human Vaccines & Immunotherapeutics
Minling Gao, Mengting Lv, Meng Han, Wenhua Song, Dong Wang
To determine the behavior of oxytetracycline (OTC) and heavy metals in soil, this study assessed the pollutant-induced avoidance behavior of earthworms (E. fetida) exposed to zinc (Zn(2+)), lead (Pb(2+)), and OTC in soil. The results showed a clear avoidance response within 48h of exposure to the highest concentrations of pollutants. Moreover, E. fetida was shown to be more sensitive to Zn(2+) than to Pb(2+) and OTC. Compared with OTC alone, the net response of earthworms increased in the OTC-Zn(2+) and OTC-Pb(2+) combined treatments, indicating a synergistic effect...
September 19, 2016: Environmental Toxicology and Pharmacology
Irene Laurora, Yuan Wang
PURPOSE: Extended-release (ER) naproxen sodium provides pain relief for up to 24 hours with a single dose (660 mg/day). Its pharmacokinetic profile after single and multiple dosing was compared to immediate release (IR) naproxen sodium in two randomized, open-label, crossover studies, under fasting and fed conditions. METHODS: Eligible healthy subjects were randomized to ER naproxen sodium 660-mg tablet once daily or IR naproxen sodium 220-mg tablet twice daily (440 mg initially, followed by 220 mg 12 hours later)...
October 2016: International Journal of Clinical Pharmacology and Therapeutics
(no author information available yet)
The Food and Drug Administration (FDA, we, or the Agency) is issuing this final rule establishing that certain active ingredients used in over-the-counter (OTC) consumer antiseptic products intended for use with water (referred to throughout this document as consumer antiseptic washes) are not generally recognized as safe and effective (GRAS/GRAE) and are misbranded. FDA is issuing this final rule after considering the recommendations of the Nonprescription Drugs Advisory Committee (NDAC); public comments on the Agency's notices of proposed rulemaking; and all data and information on OTC consumer antiseptic wash products that have come to the Agency's attention...
September 6, 2016: Federal Register
Zhetai Hu, Peide Sun, Zhirong Hu, Jingyi Han, Ruyi Wang, Liang Jiao, Pengfei Yang
The effects of Erythromycin (ERY) and oxytetracycline (OTC), including individual and combinative effect, on enhanced biological phosphorus removal (EBPR) system within a short-term (24h) were evaluated in this study. Results showed that the P-removal efficiency decreased to 34.6% and 0.0% under the effect of ERY (10mg/L) and OTC (10mg/L) for 24h. OTC concentration higher than 5mg/L was sufficient to cause serious adverse impact on the EBPR performance. While the performance of EBPR system will be impacted by ERY above 10mg/L...
December 2016: Bioresource Technology
Monika Wójta-Kempa, Dominik M Krzyżanowski
BACKGROUND: Almost 90% of households in Poland buy medicines on their own initiative. The most popular OTC medicines bought by Polish consumers are painkillers and non-steroid-anti-inflammatory drugs. OBJECTIVES: The aim of this article was to recognize and describe the most important predictive factors of the abuse and misuse of over-the-counter pain relievers among adults in Wrocław (Poland). The groups of users were selected and described. Some examples of misuse were analyzed...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Eva L Pijpers, Sanne Kreijkamp-Kaspers, Treasure M McGuire, Laura Deckx, Wendy Brodribb, Mieke L van Driel
BACKGROUND: For many medicines, safe use during pregnancy is not established and adherence is often poor due to safety concerns. Therefore, it is important to identify consumers' medicines information needs during pregnancy. MATERIALS AND METHODS: A retrospective, mixed methods analysis was conducted on eight years of pregnancy-related calls to an Australian national medicines call centre. The call profile of pregnancy and non-pregnancy-related questions were compared...
September 14, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Alejandra Huete-Soto, Humberto Castillo-González, Mario Masís-Mora, Juan Salvador Chin-Pampillo, Carlos E Rodríguez-Rodríguez
Biopurification systems (BPS) are design to remove pesticides from agricultural wastewater. This work assays for the first time the potential effect of an antibiotic of agricultural use (oxytetracycline, OTC) on the performance of a biomixture (biologically active core of BPS), considering that antibiotic-containing wastewaters are also produced in agricultural labors. The respiration of the biomixture was stimulated in the presence of increasing doses of OTC (≥100mgkg(-1)), and only slightly increased with lower doses (≤10mgkg(-1))...
September 1, 2016: Journal of Hazardous Materials
Jeffery L Milleman, Kimberly R Milleman, Sylvia L Santos, Howard M Proskin, Kirstin K Battershell, James C DiMarino
BACKGROUND: The efficacy of stannous fluoride toothpastes is well established for reducing caries, plaque, and gingivitis and relieving the discomfort of dentin hypersensitivity. Management of dry mouth may include relief remedies in addition to usual oral hygiene methods to maintain oral health and improve quality of life. This 6-week, single-blind, randomized, two-period crossover clinical study was designed to evaluate the oral tolerance and potential of Enamelon® Preventive Treatment Gel (EPTG), with 0...
September 2016: Compendium of Continuing Education in Dentistry
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