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https://www.readbyqxmd.com/read/29457190/family-based-interventions-targeting-improvements-in-health-and-family-outcomes-of-children-and-adolescents-with-type-1-diabetes-a-systematic-review
#1
REVIEW
Marissa A Feldman, Lindsay M Anderson, Jenna B Shapiro, Aneta M Jedraszko, Meredyth Evans, Lindsey E G Weil, Kimberly P Garza, Jill Weissberg-Benchell
PURPOSE OF REVIEW: A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Control and Compliance Trial (DCCT). Interventions are summarized and findings reviewed to help guide clinical practice and future research. RECENT FINDINGS: Twenty-five RCTs are reviewed...
February 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29456928/behavioural-and-emotional-disorders-in-childhood-a-brief-overview-for-paediatricians
#2
REVIEW
Michael O Ogundele
Mental health problems in children and adolescents include several types of emotional and behavioural disorders, including disruptive, depression, anxiety and pervasive developmental (autism) disorders, characterized as either internalizing or externalizing problems. Disruptive behavioural problems such as temper tantrums, attention deficit hyperactivity disorder, oppositional, defiant or conduct disorders are the commonest behavioural problems in preschool and school age children. The routine Paediatric clinic or Family Medicine/General Practitioner surgery presents with several desirable characteristics that make them ideal for providing effective mental health services to children and adolescents...
February 8, 2018: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29455939/strategies-to-facilitate-shared-decision-making-about-pediatric-oncology-clinical-trial-enrollment-a-systematic-review
#3
REVIEW
Eden G Robertson, Claire E Wakefield, Christina Signorelli, Richard J Cohn, Andrea Patenaude, Claire Foster, Tristan Pettit, Joanna E Fardell
OBJECTIVE: We conducted a systematic review to identify the strategies that have been recommended in the literature to facilitate shared decision-making regarding enrolment in pediatric oncology clinical trials. METHODS: We searched seven databases for peer-reviewed literature, published 1990-2017. Of 924 articles identified, 17 studies were eligible for the review. We assessed study quality using the 'Mixed-Methods Appraisal Tool'. We coded the results and discussions of papers line-by-line using nVivo software...
February 11, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29455861/children-s-developing-ideas-about-knowledge-and-its-acquisition
#4
Samuel Ronfard, Deborah T Bartz, Liao Cheng, Xinkui Chen, Paul L Harris
We review key aspects of young children's concept of knowledge. First, we discuss children's early insights into the way that information can be communicated from informant to recipient as well as their active search for information via questions. We then analyze the way that preschool children talk explicitly and cogently about knowledge and the presuppositions they make in doing so. We argue that all children, irrespective of culture and language, eventually arrive at the same fundamental conception of knowledge in the preschool years...
2018: Advances in Child Development and Behavior
https://www.readbyqxmd.com/read/29455659/receptor-tyrosine-kinases-and-downstream-pathways-as-druggable-targets-for-cancer-treatment-the-current-arsenal-of-inhibitors
#5
REVIEW
Wagner Ricardo Montor, Andrei Ronaldo Oliveira Silva Escartin Salas, Fabiana Henriques Machado de Melo
Searching for targets that allow pharmacological inhibition of cell proliferation in over-proliferative states, such as cancer, leads us to finely understand the complex mechanisms orchestrating the perfect control of mitosis number, frequency and pace as well as the molecular arrangements that induce cells to enter functional quiescence and brings them back to cycling in specific conditions. Although the mechanisms regulating cell proliferation have been described several years ago, never before has so much light been shed over this machinery as during the last decade when therapy targets have been explored and molecules, either synthetic or in the form of antibodies with the potential of becoming cancer drugs were produced and adjusted for specific binding and function...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29455580/from-family-involvement-to-family-inclusion-in-nursing-home-settings-a-critical-interpretive-synthesis
#6
Gloria Puurveen, Jennifer Baumbusch, Preet Gandhi
The provision of care work by families plays an integral role in the quality of life of older adults living in a nursing home setting. This critical interpretive synthesis examines family members' perceptions of their roles and responsibilities in nursing home settings and interrogates the structural and relational barriers and enablers to family involvement as they relate to fostering an inclusive environment. Electronic databases and published literature were searched for empirical studies that were conducted in a nursing home setting and described involvement from the perspective of family members...
February 1, 2018: Journal of Family Nursing
https://www.readbyqxmd.com/read/29454849/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-intracellular-signaling-pathways-tyrosine-kinase-and-mtor-inhibitors
#7
REVIEW
Mark Reinwald, Jose T Silva, Nicolas J Mueller, Jesús Fortún, Christian Garzoni, Johan W de Fijter, Mario Fernández-Ruiz, Paolo Grossi, Jose María Aguado
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of therapies targeting different intracellular signaling pathways and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29454710/experiences-of-guilt-shame-and-blame-in-those-affected-by-burns-a-qualitative-systematic-review
#8
REVIEW
Rachel Kornhaber, Charmaine Childs, Michelle Cleary
BACKGROUND: A significant burn can severely impact the lives of survivors and their carers. This systematic review sought to incorporate the experiences of guilt, blame and shame across the lifespan for burn survivors, their families as well as the experiences of the parents of burned children. METHODS: A systematic review of qualitative studies on the experiences and perspectives of guilt, blame and shame by those affected by burn trauma across the lifespan. The databases, Pubmed, Scopus, EMBASE, CINAHL, PsychINFO were systematically searched...
February 14, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29454308/the-unique-evolutionary-pattern-of-the-hydroxyproline-rich-glycoproteins-superfamily-in-chinese-white-pear-pyrus-bretschneideri
#9
Huijun Jiao, Xing Liu, Shuguang Sun, Peng Wang, Xin Qiao, Jiaming Li, Chao Tang, Juyou Wu, Shaoling Zhang, Shutian Tao
BACKGROUND: The hydroxyproline-rich glycoprotein (HRGP) superfamily, comprising three families (arabinogalactan-proteins, AGPs; extensins, EXTs; proline-rich proteins, PRPs), is a class of proline-rich proteins that exhibit high diversity and are involved in many aspects of plant biology. RESULTS: In this study, 838 HRGPs were identified from Chinese white pear (Pyrus bretschneideri) by searching for biased amino acid composition and conserved motifs. 405 HRGPs were derived from whole genome duplication (WGD) events which is suggested to be the major force of driving HRGPs expansion and the recent WGD event shared by apple and pear generated most duplicated HRGPs in pear...
February 17, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29454220/early-life-sexual-abuse-is-associated-with-increased-suicide-attempts-an-update-meta-analysis
#10
REVIEW
Qin Xiang Ng, Bob Zheng Jie Yong, Collin Yin Xian Ho, Donovan Yutong Lim, Wee-Song Yeo
Suicide is an emerging, yet preventable global health issue associated with significant mortality. Identification of underlying risk factors and antecedents may inform preventive strategies and interventions. This study serves to provide an updated meta-analysis examining the extent of association of early life sexual abuse with suicide attempts. Using the keywords [early abuse OR childhood abuse OR sexual OR rape OR molest* OR violence OR trauma OR PTSD] AND [suicid* OR premature OR unnatural OR deceased OR died OR mortality], a preliminary search on the PubMed, Ovid, PsychINFO, Web of Science and Google Scholar databases yielded 12,874 papers published in English between 1-Jan-1988 and 1-June-2017...
February 6, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29453969/s100-proteins-in-oral-squamous-cell-carcinoma
#11
REVIEW
Muhammad Arsalan Raffat, Naila Irum Hadi, Mervyn Hosein, Sana Mirza, Sana Ikram, Zohaib Akram
BACKGROUND: Controversy exists in the literature regarding the differential expression of S100 protein members and their functional correlations in oral squamous cell carcinoma (OSCC). The aim of the present study was to systematically review the expression of S100 protein family members among OSCC and healthy controls and to evaluate whether S100 protein members serve as diagnostic marker in OSCC. METHODS: Indexed databases were searched up to and including October 2017...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453043/understanding-of-human-atp-binding-cassette-superfamily-and-novel-multidrug-resistance-modulators-to-overcome-mdr
#12
REVIEW
Imran Shair Mohammad, Wei He, Lifang Yin
Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause of enhanced cytotoxic drug efflux and treatment failure in various types of cancers. At cellular level, the pumps of ABC family regulate the transportation of numerous substances including drugs in and out of the cells. In past, the overexpression of ABC pumps suggested a well-known mechanism of drug resistance in cancers as well as infectious diseases...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29451882/de-novo-transcriptomic-analysis-of-leaf-and-fruit-tissue-of-cornus-officinalis-using-illumina-platform
#13
Dian-Yun Hou, Lin-Chun Shi, Meng-Meng Yang, Jiong Li, Shuang Zhou, Hong-Xiao Zhang, Hua-Wei Xu
Cornus officinalis is one of the most widely used medicinal plants in China and other East Asian countries to cure diseases such as liver, kidney, cardiovascular diseases and frequent urination for thousands of years. It is a Level 3 protected species, and is one of the 42 national key protected wild species of animals and plants in China. However, the genetics and molecular biology of C. officinalis are poorly understood, which has hindered research on the molecular mechanism of its metabolism and utilization...
2018: PloS One
https://www.readbyqxmd.com/read/29451829/survivor-notification-of-post-disaster-mental-health-services-an-integrative-review
#14
Joanne C Langan, Mary M Krieger
This integrative review identifies notification methods for psychiatric mental health services for adult survivors of natural disasters for articles published from 2011 through 2016. Databases searched included Scopus, Cochrane Library, CINAHL Plus, Ovid MEDLINE, and Ovid PsycINFO. The search was limited to English language. Initially, 273 titles/abstracts were reviewed, and 18 articles were retained for synthesis. Communication occurs through formal means of health care provider referrals and online programs (72%); informal supports are friends, family and clergy (28%)...
February 16, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29451689/barriers-to-accessing-palliative-care-for-pediatric-patients-with-cancer-a-review-of-the-literature
#15
REVIEW
Emily R Haines, A Corey Frost, Heather L Kane, Franziska S Rokoske
Although many of the 16,000 children in the United States diagnosed who are with cancer each year could benefit from pediatric palliative care, these services remain underused. Evidence regarding the barriers impeding access to comprehensive palliative care is dispersed in the literature, and evidence specific to pediatric oncology remains particularly sparse. The purpose of the current review was to synthesize the existing literature regarding these barriers and the strategies offered to address them. The authors completed a literature search using the PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science databases...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29451451/critical-assessment-of-pediatric-neurosurgery-patient-parent-educational-information-obtained-via-the-internet
#16
Michael Garcia, Christopher Daugherty, Bertha Ben Khallouq, Todd Maugans
OBJECTIVE The Internet is used frequently by patients and family members to acquire information about pediatric neurosurgical conditions. The sources, nature, accuracy, and usefulness of this information have not been examined recently. The authors analyzed the results from searches of 10 common pediatric neurosurgical terms using a novel scoring test to assess the value of the educational information obtained. METHODS Google and Bing searches were performed for 10 common pediatric neurosurgical topics (concussion, craniosynostosis, hydrocephalus, pediatric brain tumor, pediatric Chiari malformation, pediatric epilepsy surgery, pediatric neurosurgery, plagiocephaly, spina bifida, and tethered spinal cord)...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29449128/meta-analysis-on-the-association-between-brain-derived-neurotrophic-factor-polymorphism-rs6265-and-ischemic-stroke-poststroke-depression
#17
Mei-Hua Bao, Shu-Zhen Zhu, Xin-Zheng Gao, Hong-Shuo Sun, Zhong-Ping Feng
BACKGROUND: Ischemic stroke is a multifactorial neurologic injury that causes mortality and disability worldwide. Poststroke depression is the most important neuropsychiatric consequence of stroke. Brain-derived neurotrophic factor is a neurotrophin family member that plays key role in regulating neuron survival and differentiation. Studies found a polymorphism in brain-derived neurotrophic factor gene (rs6265) may associate with the ischemic stroke and poststroke depression risk. However, the results are inconclusive and inconsistent...
February 13, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29449029/development-of-alcohol-expectancies-and-early-alcohol-use-in-children-and-adolescents-a-systematic-review
#18
REVIEW
Koen Smit, Carmen Voogt, Marieke Hiemstra, Marloes Kleinjan, Roy Otten, Emmanuel Kuntsche
PURPOSE: Developmental changes in alcohol expectancies (AE) have been proposed to lead to alcohol use initiation and later alcohol use in adolescence. This systematic review aims to provide longitudinal evidence of the development of AE and the relation of AE to alcohol outcomes from childhood to late adolescence (4-18 years old). METHODS: A computer-assisted search of relevant articles identified 1602 studies, of which 43 studies (conducted between 1996 and 2016) were selected...
February 6, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29447988/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-agents-targeting-lymphoid-cells-surface-antigens-i-cd19-cd20-and-cd52
#19
REVIEW
Małgorzata Mikulska, Simone Lanini, Carlota Gudiol, Lubos Drgona, Giuseppe Ippolito, Mario Fernández-Ruiz, Bernd Salzberger
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting CD19, CD20 and CD52 and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29447987/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-soluble-immune-effector-molecules-ii-agents-targeting-interleukins-immunoglobulins-and-complement
#20
REVIEW
Kevin L Winthrop, Xavier Mariette, Jose T Silva, Esther Benamu, Leonard H Calabrese, Alexandre Dumusc, Josef S Smolen, José María Aguado, Mario Fernández-Ruiz
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting interleukins, immunoglobulins and complement factors and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 12, 2018: Clinical Microbiology and Infection
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