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https://www.readbyqxmd.com/read/29679134/aphallia-a-review-to-standardize-management
#1
REVIEW
Tarryn Gabler, Robyn Charlton, Jerome Loveland, Ellen Mapunda
Congenital aphallia is a rare anomaly with little supporting literature and controversial management. The aim of this review is to assess the most recent literature with a focus on staged management of these cases. We performed a PubMed search of all English literature in the past 10 years using the term aphallia. Twenty-three articles were identified of which six were excluded. A further three papers meeting our criteria were found in the references to papers initially identified. We found that management can be staged in three phases: short, intermediate and long-term...
April 20, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29678991/measurement-properties-of-the-health-of-the-nation-outcome-scales-honos-family-of-measures-protocol-for-a-systematic-review
#2
Meredith G Harris, Claudia Sparti, Roman Scheurer, Tim Coombs, Jane Pirkis, Torleif Ruud, Steve Kisely, Ketil Hanssen-Bauer, Johan Siqveland, Philip M Burgess
INTRODUCTION: The Health of the Nation Outcome Scales (HoNOS) for adults, and equivalent measures for children and adolescents and older people, are widely used in clinical practice and research contexts to measure mental health and functional outcomes. Additional HoNOS measures have been developed for special populations and applications. Stakeholders require synthesised information about the measurement properties of these measures to assess whether they are fit for use with intended service settings and populations and to establish performance benchmarks...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678157/psycho-social-impact-of-stillbirths-on-women-and-their-families-in-tamil-nadu-india-a-qualitative-study
#3
Vijayaprasad Gopichandran, Sudharshini Subramaniam, Maria Jusler Kalsingh
BACKGROUND: Stillbirth has serious psycho-social consequences on the parents and on the family. The psychological impact of stillbirth is strongly influenced by the social and cultural context. There is very scarce information on this from the Indian context. This qualitative study was conducted to understand the psycho-social impact, aggravating factors, coping styles and health system response to stillbirths. METHODS: A qualitative study was conducted using in-depth interviews with mothers who experienced stillbirth in the past 1 year and their families...
April 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29675633/vapor-nucleation-paths-in-lyophobic-nanopores
#4
Antonio Tinti, Alberto Giacomello, Carlo Massimo Casciola
In recent years, technologies revolving around the use of lyophobic nanopores gained considerable attention in both fundamental and applied research. Owing to the enormous internal surface area, heterogeneous lyophobic systems (HLS), constituted by a nanoporous lyophobic material and a non-wetting liquid, are promising candidates for the efficient storage or dissipation of mechanical energy. These diverse applications both rely on the forced intrusion and extrusion of the non-wetting liquid inside the pores; the behavior of HLS for storage or dissipation depends on the hysteresis between these two processes, which, in turn, are determined by the microscopic details of the system...
April 19, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29675401/analysis-of-the-antigenic-and-prophylactic-properties-of-the-leishmania-translation-initiation-factors-eif2-and-eif2b-in-natural-and-experimental-leishmaniasis
#5
Esther Garde, Laura Ramírez, Laura Corvo, José C Solana, M Elena Martín, Víctor M González, Carlos Gómez-Nieto, Aldina Barral, Manoel Barral-Netto, José M Requena, Salvador Iborra, Manuel Soto
Different members of intracellular protein families are recognized by the immune system of the vertebrate host infected by parasites of the genus Leishmania . Here, we have analyzed the antigenic and immunogenic properties of the Leishmania eIF2 and eIF2B translation initiation factors. An in silico search in Leishmania infantum sequence databases allowed the identification of the genes encoding the α, β, and γ subunits and the α, β, and δ subunits of the putative Leishmania orthologs of the eukaryotic initiation factors F2 (LieIF2) or F2B (LieIF2B), respectively...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29674954/bioinformatic-integration-of-molecular-networks-and-major-pathways-involved-in-mice-cochlear-and-vestibular-supporting-cells
#6
Teresa Requena, Alvaro Gallego-Martinez, Jose A Lopez-Escamez
Background : Cochlear and vestibular epithelial non-hair cells (ENHCs) are the supporting elements of the cellular architecture in the organ of Corti and the vestibular neuroepithelium in the inner ear. Intercellular and cell-extracellular matrix interactions are essential to prevent an abnormal ion redistribution leading to hearing and vestibular loss. The aim of this study is to define the main pathways and molecular networks in the mouse ENHCs. Methods : We retrieved microarray and RNA-seq datasets from mouse epithelial sensory and non-sensory cells from gEAR portal (http://umgear...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29673686/the-impact-of-demographic-health-related-and-social-factors-on-dental-services-utilization-systematic-review-and-meta-analysis
#7
REVIEW
Seif Magdy Reda, Joachim Krois, Sophie Franziska Reda, William Murray Thomson, Falk Schwendicke
OBJECTIVES: Regular and/or preventive dental services utilization is an indicator of healthcare access and associated with improved health outcomes. We assessed the proportion of individuals regularly/preventively utilizing dental services, and how this was affected by demographic, health-related and social factors. SOURCES: Three electronic databases (Medline, Embase, Central) were searched (2005-2017). STUDY SELECTION: We included observational studies investigating the association between preventive/regular dental service utilization and age, oral and general health, edentulism, family structure and health literacy...
April 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#8
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29672937/see-reflect-learn-more-qualitative-analysis-of-breaking-bad-news-reflective-narratives
#9
Orit Karnieli-Miller, Michal Palombo, Dafna Meitar
CONTEXT: Breaking bad news (BBN) is a challenge that requires multiple professional competencies. BBN teaching often includes didactic and group role-playing sessions. Both are useful and important, but exclude another critical component of students' learning: day-to-day role-model observation in the clinics. Given the importance of observation and the potential benefit of reflective writing in teaching, we have incorporated reflective writing into our BBN course. The aim of this study was to enhance our understanding of the learning potential in reflective writing about BBN encounters and the ability to identify components that inhibit this learning...
May 2018: Medical Education
https://www.readbyqxmd.com/read/29672851/human-hepatocellular-carcinoma-protection-by-melatonin
#10
REVIEW
Keywan Mortezaee
Despite great scientific breakthroughs toward understanding the identity of human hepatocellular carcinoma (HCC) mechanistically, there are still no clinically efficient therapeutic methods for this cancer. Melatonin (N-acetyl-5-methoxytryptamine) is a multi-tasking hormone that has long been known for its anti-cancer activity against various human cancers including HCC, which is a focus of this review. PubMed database was searched for relevant articles with the keywords: hepatocellular carcinoma (HCC), melatonin, apoptosis, proliferation, invasion, angiogenesis, autophagy, oxidative stress, tumor immunity, and mitogen-activated protein kinase (MAPK) focusing on just human cell lines and English language articles...
April 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29672608/psychosocial-interventions-for-rehabilitation-and-reintegration-into-daily-life-of-pediatric-cancer-survivors-and-their-families-a-systematic-review
#11
Mona Leandra Peikert, Laura Inhestern, Corinna Bergelt
BACKGROUND: The survival rate of childhood cancer patients increased over the past decades. However, even after successful treatment the transition back to normalcy is often a major challenge for the whole family. Therefore, this study aims to provide an overview of psychosocial interventions for childhood cancer survivors and their families in the first years after the end of cancer treatment. METHODS: We conducted a systematic review following the PRISMA Checklist (Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PROSPERO registration number: CRD42017059782)...
2018: PloS One
https://www.readbyqxmd.com/read/29671281/validation-of-caregiver-centered-delirium-detection-tools-a-systematic-review
#12
REVIEW
Brianna Rosgen, Karla Krewulak, Danielle Demiantschuk, E Wesley Ely, Judy E Davidson, Henry T Stelfox, Kirsten M Fiest
OBJECTIVES: To summarize the validity of caregiver-centered delirium detection tools in hospitalized adults and assess associated patient and caregiver outcomes. DESIGN: Systematic review. SETTING: We searched MEDLINE, EMBASE, PsycINFO, CINAHL, and Scopus from inception to May 15, 2017. PARTICIPANTS: Hospitalized adults. INTERVENTION: Caregiver-centered delirium detection tools. MEASUREMENTS: We drafted a protocol from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
April 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29669463/genetic-variation-at-chromosome-2q13-and-its-potential-influence-on-endometriosis-susceptibility-through-effects-on-the-il-1-family
#13
Rahul Gajbhiye, Brett McKinnon, Sally Mortlock, Michael Mueller, Grant Montgomery
Endometriosis is characterized by the growth of epithelial and stromal cells outside the uterine cavity. It has a complex etiology and affects ∼10% of reproductive age women. It is accompanied by a chronic inflammatory response with substantial evidence to indicate genetic susceptibility. The causal genes and their pathways leading to endometriosis, however, are still unknown. Recently, genomewide association studies on endometriosis identified 14 genomic risk loci in women of European and Japanese ancestry...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29669175/antidepressants-for-preventing-postnatal-depression
#14
REVIEW
Emma Molyneaux, Laurence A Telesia, Carol Henshaw, Elizabeth Boath, Eleanor Bradley, Louise M Howard
BACKGROUND: Depression is common in the postnatal period and can lead to adverse effects on the infant and wider family, in addition to the morbidity for the mother. It is not clear whether antidepressants are effective for the prevention of postnatal depression and little is known about possible adverse effects for the mother and infant, particularly during breastfeeding. This is an update of a Cochrane Review last published in 2005. OBJECTIVES: To assess the effectiveness of antidepressant medication for the prevention of postnatal depression, in comparison with any other treatment, placebo or standard care...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29669108/genomic-context-of-resistance-genes-within-a-french-clinical-mdr-proteus-mirabilis-identification-of-the-novel-genomic-resistance-island-gipmi1
#15
Eliane Siebor, Claire de Curraize, Catherine Neuwirth
Objectives: To determine the location of the antibiotic resistance genes in the MDR Proteus mirabilis PmPHI clinical isolate. Methods: WGS and de novo assembly were performed. BLAST searches were used to identify relevant contigs. PCR and Sanger sequencing were used to link the fragments of interest and fill the gaps. Results: P. mirabilis PmPHI was resistant to six classes of antibiotics: penicillins, aminoglycosides, phenicols, tetracyclines, folate inhibitors and fluoroquinolones...
April 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29669089/what-works-and-does-not-work-in-a-self-management-intervention-for-people-with-chronic-pain-qualitative-systematic-review-and-meta-synthesis
#16
Hemakumar Devan, Leigh Hale, Dagmar Hempel, Barbara Saipe, Meredith A Perry
Background: Self-management interventions fostering self-efficacy improve the well-being of people with chronic pain. Purpose: The purpose of this study was to synthesize the enablers (what works) and barriers (what does not) of incorporating self-management strategies for people in everyday life after completion of a pain self-management intervention. Data Sources: Major electronic databases (MEDLINE, AMED, PsycINFO, Cochrane Library, PubMed, CINAHL, Scopus, and Google Scholar) were searched from inception to July 2016...
May 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29668791/spirituality-in-palliative-care-experiences-of-an-interdisciplinary-team
#17
Isabel Cristina de Oliveira Arrieira, Maira Buss Thofehrn, Adrize Rutz Porto, Pedro Márlon Martter Moura, Caroline Lemos Martins, Michelle Barboza Jacondino
Objective To understand the experience of spirituality in the daily routine of a palliative care interdisciplinary team. Method A qualitative study was conducted with an oncological palliative care team in southern Brazil. The data was collected through phenomenological interviews in 2014, and interpreted using a hermeneutic phenomenological approach. Results Six professionals participated in the study. Spiritually-related activities, such as prayer and providing comprehensive care, were useful therapeutic resources for offering comfort, survival with dignity and humanization of death, in addition to helping the team and patients understand the end-of-life process and search for meaning in the suffering caused by illness...
2018: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29668722/a-family-of-long-intergenic-non-coding-rna-genes-in-human-chromosomal-region-22q11-2-carry-a-dna-translocation-breakpoint-at-rich-sequence
#18
Nicholas Delihas
FAM230C, a long intergenic non-coding RNA (lincRNA) gene in human chromosome 13 (chr13) is a member of lincRNA genes termed family with sequence similarity 230. An analysis using bioinformatics search tools and alignment programs was undertaken to determine properties of FAM230C and its related genes. Results reveal that the DNA translocation element, the Translocation Breakpoint Type A (TBTA) sequence, which consists of satellite DNA, Alu elements, and AT-rich sequences is embedded in the FAM230C gene. Eight lincRNA genes related to FAM230C also carry the TBTA sequences...
2018: PloS One
https://www.readbyqxmd.com/read/29668012/evolution-of-dnmt2-in-drosophilids-evidence-for-positive-and-purifying-selection-and-insights-into-new-protein-pathways-interactions
#19
Gilberto Cavalheiro Vieira, Marícia Fantinel D'Ávila, Rebeca Zanini, Maríndia Deprá, Vera Lúcia da Silva Valente
The DNA methyltransferase 2 (DNMT2) protein is the most conserved member of the DNA methyltransferase family. Nevertheless, its substrate specificity is still controversial and elusive. The genomic role and determinants of DNA methylation are poorly understood in invertebrates, and several mechanisms and associations are suggested. In Drosophila, the only known DNMT gene is Dnmt2. Here we present our findings from a wide search for Dnmt2 homologs in 68 species of Drosophilidae. We investigated its molecular evolution, and in our phylogenetic analyses the main clades of Drosophilidae species were recovered...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#20
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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