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Callum J Donaldson, Stuart L Mitchell, Lee H Riley, Khaled Kebaish
STUDY DESIGN: Case report and literature review. OBJECTIVE: To characterize the rare presentati on of myelopathy occurring secondary to alkaptonuria and to evaluate the available evidence regarding its treatment. SUMMARY OF BACKGROUND DATA: Alkaptonuria is an autosomal recessive genetic condition with an estimated incidence of 1 in 250,000 to 1 in 1,000,000 people. Mutation of the enzyme homogentisate 1,2-dioxygenase leads to the production of high levels of homogentisic acid (HGA), with subsequent deposition in ligaments, cartilage, and menisci...
June 21, 2018: Spine
Gholamreza Ghassemi Todeshkchuei, Mitra Molaeinezhad, Sare Ghasemi Todeshkchuei
Suicide is one of the public health problems worldwide, but it lacks regular relevant reporting system. This issue is more important among women who play an influential role in the family and society. Therefore, the assessment of recent relevant studies is important to detect suicide-related factors and to help make the decisions about public health. The aim of the current study was to determine socioeconomic and psychological factors of suicide attempts in Iranian women using a descriptive meta-analysis method...
2018: Advanced Biomedical Research
Jorge Barriuso, María J Martínez
Quorum sensing (QS) is a sophisticated cell to cell signaling mechanism mediated by small diffusible molecules called "autoinducers." This phenomenon is well studied in bacteria, where different QS systems are described that differ between Gram-negative and Gram-positive bacteria. However, a common system to these groups was discovered, the autoinducer 2. QS has implications in biofilm formation, where the application of metagenomic techniques to study these phenomena may be useful to understand the communication networks established by the different components of the community, and to discover new targets for microbial control...
2018: Frontiers in Microbiology
Shuqin Jia, Meng Zhang, Yu Sun, Hai Yan, Fangping Zhao, Ziyu Li, Jiafu Ji
BACKGROUND: Lynch syndrome (LS) is caused by mutations in DNA mismatch repair (MMR) genes, which accounts for 3-5% of colorectal cancer. The risks of several types of cancer are greatly increased among individuals with LS. In this study, 4 members of a Chinese family with a MLH1 pathogenic variant, resulting in colonic carcinoma, was reported. CASE PRESENTATION: A 52-year-old colon cancer female was brought to us with a family history of colon cancer. Genetic counseling traced 4 members in her family with colon cancer (mother and 3 siblings including the proband) as well as other cancer types...
June 22, 2018: BMC Medical Genetics
Megan E Cahill, Samantha Conley, Andrew T DeWan, Ruth R Montgomery
BACKGROUND: Dengue and West Nile viruses are highly cross-reactive and have numerous parallels in geography, potential vector host (Aedes family of mosquitoes), and initial symptoms of infection. While the vast majority (> 80%) of both dengue and West Nile virus infections result in asymptomatic infections, a minority of individuals experience symptomatic infection and an even smaller proportion develop severe disease. The mechanisms by which these infections lead to severe disease in a subset of infected individuals is incompletely understood, but individual host differences including genetic factors and immune responses have been proposed...
June 22, 2018: BMC Infectious Diseases
Oxana Galzitskaya, Eugenia Deryusheva, Andrey Machulin, Ekaterina Nemashkalova, Anna Glyakina
High prediction accuracy of flexible loops in different protein families is a challenge because of the crucial functions associated with these regions. Results of the currently available programs for prediction of loops vary from protein to protein. For prediction of flexible regions in the G-domain for 23 representatives of G-proteins with the known 3D structure we have used eight programs. The results of predictions demonstrate that the FoldUnfold program predicts better loop positions than the PONDR, RОNN, DisEMBL, IUPred, GlobPlot 2, FoldIndex, and MobiDB programs...
June 21, 2018: Protein and Peptide Letters
Ioanna Kalvari, Eric P Nawrocki, Joanna Argasinska, Natalia Quinones-Olvera, Robert D Finn, Alex Bateman, Anton I Petrov
Rfam is a database of non-coding RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. Using a combination of manual and literature-based curation and a custom software pipeline, Rfam converts descriptions of RNA families found in the scientific literature into computational models that can be used to annotate RNAs belonging to those families in any DNA or RNA sequence. Valuable research outputs that are often locked up in figures and supplementary information files are encapsulated in Rfam entries and made accessible through the Rfam Web site...
June 5, 2018: Current Protocols in Bioinformatics
Andréa Neiva da Silva, Solimar Tavares Alvares de Lima, Mario Vianna Vettore
BACKGROUND: Psychosocial protective factors include dispositional and family attributes that may reduce the occurrence of dental caries. AIM: This review analysed the evidence on the relationship between protective psychosocial factors and dental caries in children and adolescents. DESIGN: Primary studies involving children and adolescents were searched in the following electronic databases: Medline, SCOPUS, LILACS, SciELO, and Web of Science...
June 21, 2018: International Journal of Paediatric Dentistry
Debrework Tesgera Bashah, Abebaw Gebeyehu Worku, Mezgebu Yitayal Mengistu
BACKGROUND: Women with fistula live in a state of distress and in fear of their future life. An obstetric fistula has a devastating impact on affected women and their families. The objective of this systematic review was to synthesize the evidence from published articles on the consequences of obstetric fistula on women who endure the condition. METHODS: The consequences were systematically reviewed from purely qualitative and mixed method primary studies. The literatures were searched through the search engines Google, Google scholar, Hinari using Pub Med data bases, and citation tracking...
June 20, 2018: BMC Women's Health
Wai Hoong Chang, Alvina G Lai
BACKGROUND: Animals are thought to achieve lignocellulose digestion via symbiotic associations with gut microbes; this view leads to significant focus on bacteria and fungi for lignocellulolytic systems. The presence of biomass conversion systems hardwired into animal genomes has not yet been unequivocally demonstrated. RESULTS: We perform an exhaustive search for glycoside hydrolase (GH) genes from 21 genomes representing major bilaterian (Ecdysozoa, Spiralia, Echinodermata and Chordata) and basal metazoan (Porifera and Cnidaria) lineages...
June 20, 2018: BMC Genomics
Michelle L Wright, Christina Fournier, Madelyn C Houser, Malú Tansey, Jonathan Glass, Vicki Stover Hertzberg
Amyotrophic lateral sclerosis (ALS) etiology and pathophysiology are not well understood. Recent data suggest that dysbiosis of gut microbiota may contribute to ALS etiology and progression. This review aims to explore evidence of associations between gut microbiota and ALS etiology and pathophysiology. Databases were searched for publications relevant to the gut microbiome in ALS. Three publications provided primary evidence of changes in microbiome profiles in ALS. An ALS mouse model revealed damaged tight junction structure and increased permeability in the intestine versus controls along with a shifted microbiome profile, including decreased levels of butyrate-producing bacteria...
January 1, 2018: Biological Research for Nursing
L L Zhao, X D Zhai, Z Zhang, Z Lü, Z Y Xia, Y N Mo
OBJECTIVES: To detect 715 bp sequence of 28S rRNA in sarcosaphagous flies, and to identify their common species for solving the problem of morphological identification, as well as providing technical support for postmortem interval (PMI) estimation. METHODS: Twenty-nine common sarcosaphagous flies were collected in Luoyang and classified by morphological characteristics. The DNA was extracted from the fly's legs by Chelex-100 method and then the fragments of 28S rRNA were amplified and sequenced...
April 2018: Fa Yi Xue za Zhi
Dominika Piasecka, Marcin Braun, Radzislaw Kordek, Rafal Sadej, Hanna Romanska
PURPOSE: Dysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy...
June 19, 2018: Journal of Cancer Research and Clinical Oncology
M Chakhtoura, M S Ramnitz, N Khoury, G Nemer, N Shabb, A Abchee, A Berberi, M Hourani, M Collins, S Ichikawa, G El Hajj Fuleihan
Hyperphosphatemic familial tumoral calcinosis (HFTC), secondary to fibroblast growth factor 23 (FGF23) gene mutation, is a rare genetic disorder characterized by recurrent calcified masses. We describe young Lebanese cousins presenting with HFTC, based on a retrospective chart review and a prospective case study. In addition, we present a comprehensive review on the topic, based on a literature search conducted in PubMed and Google Scholar, in 2014 and updated in December 2017. While the patients had the same previously reported FGF23 gene mutation (homozygous c...
June 20, 2018: Osteoporosis International
Samiullah Khan, Aqsa Gul, Rabia Noreen, Muhammad Ashraf, Sohail Ahmad, Sattar Bakhsh Awan
BACKGROUND: Thrombus is composed of two main substances i.e. red blood cells and aggregated platelets which make a web of inter-connected fibrin proteins. During injury it prevents bleeding, so it is very useful but it can be very dangerous if it is produced in healthy blood vessels and block the blood flow through it. Mural thrombi attaches with the blood vessels but in most cases do not block it completely. Venoms are an incredible source of peptides having amazing bioactivities with varying number of amino acid residues...
June 13, 2018: Protein and Peptide Letters
Kirsty Killick, Leah Macaden, Annetta Smith, Thilo Kroll, Kathleen Stoddart, Margaret C Watson
OBJECTIVES: This scoping review collated evidence of the pharmaceutical care needs of people with sensory loss (SL). METHODS: Electronic databases were searched with no limit on year of publication: Medline (1946); Embase; Cinahl (1979); and Web of Science (1985). Search terms included the following: pharmacy; sight/hearing/dual impairment. Studies were included if they involved people with SL requiring pharmaceutical care and/or pharmacists/pharmacy support staff providing pharmaceutical care for people with SL...
June 19, 2018: International Journal of Pharmacy Practice
Rosa Michaelis, Venus Tang, Laura H Goldstein, Markus Reuber, William Curt LaFrance, Tobias Lundgren, Avani C Modi, Janelle L Wagner
Given the significant impact that psychosocial factors and epilepsy treatments can have on the health-related quality of life (HRQOL) of individuals with epilepsy and their families, there is great clinical interest in the role of psychological evaluation and treatments to improve HRQOL and comorbidities. Therefore, the International League Against Epilepsy (ILAE) charged the Psychology Task Force with the development of recommendations for clinical care based on evaluation of the evidence from their recent Cochrane review of psychological treatments in individuals with epilepsy...
June 19, 2018: Epilepsia
Cynthia Chen, Neil Kaushal, David M Scher, Shevaun M Doyle, John S Blanco, Emily R Dodwell
BACKGROUND: Clubfoot is a common congenital anomaly with multiple potential risk factors. Identification of modifiable risk factors may minimize future incidence of clubfoot. The aim of this meta-analysis was to systematically review and analyze the best clinical evidence regarding risk factors associated with clubfoot. METHODS: Medline, Embase, and Cochrane databases were systematically searched from 1967 to May 11, 2016 for studies reporting risk factors for clubfoot...
June 18, 2018: Journal of Pediatric Orthopedics
Leslie Kuhnel
The broad use of social networking and user-generated content has increased the online footprint of many individuals. A generation of healthcare professionals have grown up with online search activities as part of their everyday lives. Sites like Facebook, Twitter, and Instagram have given the public new ways to share intimate details about their public and private lives and the lives of their friends and families. As a result, careproviders have the ability to find out more about their patients with just the tap of a key or the click of a mouse...
2018: Journal of Clinical Ethics
Ann Kristin Bjørnnes, Monica Parry, Marit Leegaard, Ana Patricia Ayala, Erica Lenton, Paula Harvey, Judith McFetridge-Durdle, Michael H McGillion, Jennifer Price, Jennifer Stinson, Judy Watt-Watson
Symptom recognition and self-management is instrumental in reducing the number of deaths related to coronary artery disease (CAD) in women. The purpose of this study was to synthesize qualitative research evidence on the self-management of cardiac pain and associated symptoms in women. Seven databases were systematically searched, and the concepts of the Individual and Family Self-Management Theory were used as the framework for data extraction and analysis. Search strategies yielded 22,402 citations, from which 35 qualitative studies were included in a final meta-summary, comprising data from 769 participants, including 437 (57%) women...
June 1, 2018: Qualitative Health Research
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