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Neuro endocrin control puberty

Linlin Yang, Kailin Tang, Ying Qi, Hao Ye, Wenlian Chen, Yongyu Zhang, Zhiwei Cao
BACKGROUND: Central precocious puberty (CPP) is a common pediatric endocrine disease caused by early activation of hypothalamic-putuitary-gonadal (HPG) axis, yet the exact mechanism was poorly understood. Although there were some proofs that an altered metabolic profile was involved in CPP, interpreting the biological implications at a systematic level is still in pressing need. To gain a systematic understanding of the biological implications, this paper analyzed the CPP differential urine metabolites from a network point of view...
2012: BMC Systems Biology
Joey C Eisenmann, Eric E Wickel
In his seminal paper, Rowland clearly outlined the rationale, evidence, and implications for the biological control of physical activity. Ten years later, there has been some progress in this area related to childhood physical activity with perhaps the greatest progress being made in the areas of genetics and the neuroendocrinology of physical activity. It is clear that heredity contributes to the physical activity (and inactivity) phenotype and candidate genes are now being identified. Furthermore, animal models indicate that maternal exposure to various environmental factors may alter offspring physical activity...
August 2009: Pediatric Exercise Science
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