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immunosuppressive herbs

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https://www.readbyqxmd.com/read/27857756/effects-of-triptolide-on-hippocampal-microglial-cells-and-astrocytes-in-the-app-ps1-double-transgenic-mouse-model-of-alzheimer-s-disease
#1
Jian-Ming Li, Yan Zhang, Liang Tang, Yong-Heng Chen, Qian Gao, Mei-Hua Bao, Ju Xiang, De-Liang Lei
The principal pathology of Alzheimer's disease includes neuronal extracellular deposition of amyloid-beta peptides and formation of senile plaques, which in turn induce neuroinflammation in the brain. Triptolide, a natural extract from the vine-like herb Tripterygium wilfordii Hook F, has potent anti-inflammatory and immunosuppressive efficacy. Therefore, we determined if triptolide can inhibit activation and proliferation of microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27856301/sulfur-fumigation-reducing-systemic-exposure-of-ginsenosides-and-weakening-immunomodulatory-activity-of-ginseng
#2
Bin Ma, Winnie Lai Ting Kan, He Zhu, Song-Lin Li, Ge Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng (Ginseng Radix et Rhizoma) is used worldwide for its miracle tonic effects, especially for its immunomodulatory activities. Sulfur fumigation, a fast and convenient method to prevent pesticidal and bacterial contamination in the food industry, has been recently employed during post-harvest processing of ginseng. Our previous studies demonstrated that sulfur fumigation significantly altered the chemical profile of the bioactive ingredients in ginseng...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27693910/is-the-clinical-relevance-of-drug-food-and-drug-herb-interactions-limited-to-grapefruit-juice-and-saint-john-s-wort
#3
Stéphane Mouly, Célia Lloret-Linares, Pierre-Olivier Sellier, Damien Sene, J-F Bergmann
An interaction of drug with food, herbs, and dietary supplements is usually the consequence of a physical, chemical or physiologic relationship between a drug and a product consumed as food, nutritional supplement or over-the-counter medicinal plant. The current educational review aims at reminding to the prescribing physicians that the most clinically relevant drug-food interactions may not be strictly limited to those with grapefruit juice and with the Saint John's Wort herbal extract and may be responsible for changes in drug plasma concentrations, which in turn decrease efficacy or led to sometimes life-threatening toxicity...
September 28, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27574736/tanshinol-suppresses-cardiac-allograft-rejection-in-a-murine-model
#4
Chuanjian Lu, Yu-Qun Zeng, Huazhen Liu, Qingfeng Xie, Shengmei Xu, Kangsheng Tu, Changwei Dou, Zhenhua Dai
BACKGROUND: Achieving long-term cardiac allograft survival without continuous immunosuppression is highly desired in organ transplantation. Studies have shown that Salvia miltiorrhiza, an herb also known as danshen, improves microcirculation and is highly effective in treating coronary heart disease. Our objective is to determine whether tanshinol, an ingredient of danshen, improves cardiac allograft survival. METHODS: Fully vascularized heterotopic heart transplantation was performed using BALB/c mice as donors and C57BL/6 mice as recipients, which were then treated with tanshinol and rapamycin...
July 27, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27536673/management-of-membranous-nephropathy-in-western-countries
#5
REVIEW
Talal Alfaadhel, Daniel Cattran
BACKGROUND: Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome (NS) in adults in Western countries. In 2012, the KDIGO (Kidney Disease: Improving Global Outcomes) working group published guidelines for the management of glomerulonephritis, thus providing a template for the treatment of this condition. While being aware of the impact of the clinicians' acumen and that patients may choose a different therapeutic option due to the risks of specific drugs and also of the evolving guidelines, this review details our approach to the management of patients with IMN in a Western center (Toronto)...
September 2015: Kidney Diseases
https://www.readbyqxmd.com/read/27536672/management-of-membranous-nephropathy-in-asia
#6
REVIEW
Jing Xu, Xiaofan Hu, Jingyuan Xie, Nan Chen
BACKGROUND: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults, accounting for about 20.0% of all NS cases. With an increasing prevalence, especially in the elderly, it has received great attention in Asia. SUMMARY: Recently, the prevalence of idiopathic MN (IMN) has significantly increased among the elderly people in Asia and other places in the world. Although the exact mechanism of IMN remains unveiled, the identification of new antigens such as PLA2R and THSD7A has greatly enhanced our understanding of its pathogenesis...
September 2015: Kidney Diseases
https://www.readbyqxmd.com/read/27529236/immunosuppressive-effect-of-litsea-cubeba-l-essential-oil-on-dendritic-cell-and-contact-hypersensitivity-responses
#7
Hsin-Chun Chen, Wen-Te Chang, You-Cheng Hseu, Hsing-Yu Chen, Cheng Hsuan Chuang, Chi-Chen Lin, Meng-Shiou Lee, Ming-Kuem Lin
Litsea cubeba L., also named as Makauy, is a traditional herb and has been used as cooking condiment or tea brewing to treat diseases for aborigines. The present study was undertaken to explore the chemical compositions of the fruit essential oil of L. cubeba (LCEO) and the immunomodulatory effect of LCEO on dendritic cells and mice. The LCEO was analyzed using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) with direct injection (DI/GC) or headspace-solid phase microextraction (HS-SPME/GC)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27507204/effects-of-diammonium-glycyrrhizinate-on-hepatic-and-intestinal-udp-glucuronosyltransferases-in-rats-implication-in-herb-drug-interactions
#8
Fei-Yan Li, Hao Xie, Lin Weng, Hong Wang, Li-Juan Cao, Hai-Ping Hao, Guang-Ji Wang
Glycyrrhizin is a major bioactive component of liquorice, which exerts multiple biochemical and pharmacological activities and is frequently used in combination with other drugs in the clinic. Mycophenolate mofetil (MMF), an immunosuppressant widely used in transplant patients, is metabolized by UDP-glucuronyltransferases (UGTs). Although significant evidence supports that glycyrrhizin could interact with the cytochrome P450s (CYPs), few studies have addressed its effects on UGTs. The present study aimed at investigating the regulatory effects of diammonium glycyrrhizinate (GLN) on UGTs in vitro and in vivo...
July 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27446332/anti-allergic-effect-of-artemisia-extract-in-rats
#9
Yan Deng, Zijun Liu, Yiwei Geng
Artemisia apiacea (also known as Artemisia annua L) is a herb commonly used in traditional Chinese medicine. In the early 1970s, artemisinin was isolated and identified as the active antimalarial ingredient, and thereafter, A. apiacea and artemisinin have been studied extensively, such as anti-inflammation and antipyresis, antibacteria, antiparasitic and immunosuppression effects of A. apiacea extract. The present study investigated the extracts anti-allergic effect obtained from the dried flowering tips of A...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27431862/investigation-of-the-anti%C3%A2-asthmatic-activity-of-oridonin-on-a-mouse-model-of-asthma
#10
Jing Wang, Fengsen Li, Jianbing Ding, Ge Tian, Min Jiang, Zhen Gao, Ehbal Tuyghun
Oridonin is an extract obtained from a traditional Chinese medicinal herb, Xihuangcao. Previous studies have demonstrated that Oridonin exerts various pharmaceutical effects, such as anti‑tumor and immunosuppressive effects, as well as modulating cytokine balance. The present study identified that Oridonin could regulate the Th1/Th2 cytokine balance in mice. However, as the anti‑asthmatic effect of Oridonin is currently unknown a mouse model of asthma was used in the present study. BALB/c mice were sensitized using ovalbumin (OVA), then the sensitized mice were treated with Oridonin prior to OVA challenge...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27303658/history-of-nephrotic-syndrome-and-evolution-of-its-treatment
#11
REVIEW
Abhijeet Pal, Frederick Kaskel
The recognition, evaluation, and early treatment of nephrotic syndrome in infants and children originate from physicians dating back to Hippocrates. It took nearly another 1000 years before the condition was described for its massive edema requiring treatment with herbs and other remedies. A rich history of observations and interpretations followed over the course of centuries until the recognition of the combination of clinical findings of foamy urine and swelling of the body, and measurements of urinary protein and blood analyses showed the phenotypic characteristics of the syndrome that were eventually linked to the early anatomic descriptions from first kidney autopsies and then renal biopsy analyses...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27256977/medicinal-herbs-fructus-corni-and-semen-cuscutae-suppress-allograft-rejection-via-distinct-immune-mechanisms
#12
Xusheng Liu, Yu-Qun Zeng, Yong-Zhuo Liang, Chuan Zou, Huazhen Liu, Feifei Qiu, Chun-Lin Liang, Xiao-Wei Jin, Zi-Ren Su, Zhenhua Dai
Achieving long-term allograft survival without continuous global immunosuppression is highly desirable because constant immunosuppression causes severe side effects. Traditional Chinese medicine (TCM) has been utilized to treat numerous diseases for centuries. To seek novel immunosuppressive agents, we investigated several Chinese herbal formulas that have been shown to be effective in treating autoimmune diseases. C57BL/6 mice were transplanted with a skin graft from Balb/C donors and treated orally with the TCM...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/26998023/berberine-attenuates-myocardial-ischemia-reperfusion-injury-by-suppressing-the-activation-of-pi3k-akt-signaling
#13
Zhu Qin-Wei, L I Yong-Guang
Berberine (BBR), an isoquinoline alkaloid originally isolated from the Chinese herb Coptis chinensis (Huanglian), exhibits anti-inflammatory and immunosuppressive properties. Since myocardial ischemia/reperfusion (I/R) injury is associated with an excessive immune response, the current study was conducted to investigate the impact of BBR on myocardial I/R injury, a common disorder in clinical settings. Preconditioning of Sprague-Dawley rats with BBR (100 mg/kg/day, by gavage) for 14 days prior to the induction of I/R significantly attenuated myocardial I/R injury as manifested by a reduction in the incidence of ventricular arrhythmia and the amelioration of myocardial histological changes...
March 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26916911/astragalus-membranaceus-a-review-of-its-protection-against-inflammation-and-gastrointestinal-cancers
#14
Kathy K Auyeung, Quan-Bin Han, Joshua K Ko
Astragalus membranaceus is a major medicinal herb commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders. Among its diversified clinical applications, the potential use of this herb and its chemical constituents in treatments of inflammatory diseases and cancers has been actively investigated in recent years. Astragalus-based treatments have demonstrated significant amelioration of the toxicity induced by other concurrently administered orthodox drugs (e...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/26912097/clinical-determinants-of-calcineurin-inhibitor-disposition-a-mechanistic-review
#15
Thomas Vanhove, Pieter Annaert, Dirk R J Kuypers
The calcineurin inhibitors (CNIs) tacrolimus and cyclosporine are widely used immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic variability, both between and within patients. CNIs are highly lipophilic, poorly soluble, undergo extensive first-pass metabolism and are cleared by the liver. In both gut and liver, CNIs are substrates for the cytochrome P450 (CYP) enzymes 3A4 and 3A5 as well as the P-glycoprotein (P-gp) transporter, whose functions are determined by a complex interplay between genetic polymorphisms, the inductive or inhibitory effects of many drugs, herbs, food constituents and endogenous substances such as uremic toxins in case of end-stage renal disease...
2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/26852865/increased-systemic-exposure-of-methotrexate-by-a-polyphenol-rich-herb-via-modulation-on-efflux-transporters-multidrug-resistance-associated-protein-2-and-breast-cancer-resistance-protein
#16
Chung-Ping Yu, Yun-Chung Hsieh, Chi-Sheng Shia, Pei-Wen Hsu, Jen-Yuan Chen, Yu-Chi Hou, Yo-Wen Hsieh
Scutellariae radix (SR, roots of Scutellaria baicalensis Georgi), a popular Chinese medicine, contains plenty of flavonoids such as baicalin, wogonoside, baicalein, and wogonin. Methotrexate (MTX), an important immunosuppressant with a narrow therapeutic index, is a substrate of multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP). This study investigated the effect of SR on MTX pharmacokinetics and the underlying mechanisms. Rats were orally administered MTX alone and with 1...
January 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26721806/generation-of-regulatory-dendritic-cells-after-treatment-with-paeoniflorin
#17
Dan Chen, Yingxi Li, Xiaodong Wang, Keqiu Li, Yaqing Jing, Jinghua He, Zhaoyan Qiang, Jingzhi Tong, Ke Sun, Wen Ding, Yi Kang, Guang Li
Regulatory dendritic cells are a potential therapeutic tool for assessing a variety of immune overreaction diseases. Paeoniflorin, a bioactive glucoside extracted from the Chinese herb white paeony root, has been shown to be effective at inhibiting the maturation and immunostimulatory function of murine bone marrow-derived dendritic cells. However, whether paeoniflorin can program conventional dendritic cells toward regulatory dendritic cells and the underlying mechanism remain unknown. Here, our study demonstrates that paeoniflorin can induce the production of regulatory dendritic cells from human peripheral blood monocyte-derived immature dendritic cells in the absence or presence of lipopolysaccharide (LPS) but not from mature dendritic cells, thereby demonstrating the potential of paeoniflorin as a specific immunosuppressive drug with fewer complications and side effects...
August 2016: Immunologic Research
https://www.readbyqxmd.com/read/26634287/rhubarb-decreased-the-systemic-exposure-of-cyclosporine-a-probe-substrate-of-p-glycoprotein-and-cyp-3a
#18
Chung-Ping Yu, Hui-Ju Lin, Shiuan-Pey Lin, Chi-Sheng Shia, Pei-Hua Chang, Yu-Chi Hou, Yo-Wen Hsieh
1. Rhubarb, rhizome of Rheum palmatum L. (RP), is an important herb in clinical Chinese medicine. 2. Cyclosporine (CSP) is an immunosuppressant with narrow therapeutic window. The oral bioavailability of CSP was associated with P-glycoprotein (P-gp) and CYP 3A4. CSP was used as a probe substrate to investigate the in vivo modulation effects of RP on P-gp and CYP 3A. 3. Rats were orally administered 2.5 mg/kg of CSP with and without 0.25 and 1.0 g/kg of RP. The blood CSP concentration was determined by a specific monoclonal fluorescence polarization immunoassay...
August 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/26440666/arctigenin-suppress-th17-cells-and-ameliorates-experimental-autoimmune-encephalomyelitis-through-ampk-and-ppar-%C3%AE-ror-%C3%AE-t-signaling
#19
Wen Li, Zhihui Zhang, Kai Zhang, Zhenyi Xue, Yan Li, Zimu Zhang, Lijuan Zhang, Chao Gu, Qi Zhang, Junwei Hao, Yurong Da, Zhi Yao, Ying Kong, Rongxin Zhang
Arctigenin is a herb compound extract from Arctium lappa and is reported to exhibit pharmacological properties, including neuronal protection and antidiabetic, antitumor, and antioxidant properties. However, the effects of arctigenin on autoimmune inflammatory diseases of the CNS, multiple sclerosis (MS), and its animal model experimental autoimmune encephalomyelitis (EAE) are still unclear. In this study, we demonstrated that arctigenin-treated mice are resistant to EAE; the clinical scores of arctigenin-treated mice are significantly reduced...
October 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26380525/orally-co-administrated-oleo-gum-resin-of-commiphora-myrrha-decreases-the-bioavailability-of-cyclosporine-a-in-rats
#20
F I Al-Jenoobi, M A Alam, A M Al-Mohizea, A Ahad, M Raish
Cyclosporine A is a narrow therapeutic indexed immunosuppressant used after organ transplantation. Several herbs have been reported to alter its pharmacokinetics. Myrrh, dried oleogum resin obtained from Commiphora myrrha (Burseraceae) has been used for many common ailments. The present study was carried out to investigate the effect of myrrh on the pharmacokinetics of cyclosporine A. The rats of the control group received 60 mg/kg, p.o. cyclosporine A, and blood samples were collected at predetermined time intervals...
August 2015: Die Pharmazie
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