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https://www.readbyqxmd.com/read/27884671/anti-tumor-and-immunomodulatory-activities-induced-by-an-alkali-extracted-polysaccharide-bcap-1-from-bupleurum-chinense-via-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Xiangfu Song, Ting Ren, Zhou Zheng, Tiancheng Lu, Zhicheng Wang, Fengguo Du, Haibin Tong
Bupleurum chinense is a well-known traditional Chinese medicine. Polysaccharides extracted from medical plants possess multiple healthy benefits. In the present study, an alkali-extracted polysaccharide (BCAP-1) was isolated from Bupleurum chinense, and evaluated its physicochemical features, anti-tumor activities and immunomodulatory effects. BCAP-1 was obtained by alkali-extraction, ethanol precipitation, and fractionation by DEAE-cellulose and Sepharose CL-6B columns. BCAP-1 markedly inhibited Sarcoma 180tumor growth in tumor-bearing mice, and increased the secretion of TNF-α in serum...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27842819/bupleurum-chinense-polysaccharide-inhibit-adhesion-of-human-melanoma-cells-via-blocking-%C3%AE-1-integrin-function
#2
Haibin Tong, Guiquan Jiang, Dake Qi, Jingfeng Bi, Dan Tian, Xingang Guan, Sheng Zheng, Xin Sun
Adhesive interaction contributes toward tumor metastasis and the transmembrane glycoprotein receptor, integrin has been recognized to mediate the adhesion to extracellular matrix thus upregulating tumor metastasis. In the current study, we evaluated the anti-adhesive mechanisms of a water-soluble polysaccharide (BCP) extracted from Bupleurum chinense. BCP inhibited integrin-mediated adhesion of human melanoma A375 cells to fibronectin but had no effects on nonspecific adhesion to poly-l-lysine. BCP also reduced β1 integrin ligand affinity for GST-FNIII9-10 proteins...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27771535/protective-effects-of-a-herbal-extract-combination-of-bupleurum-falcatum-paeonia-suffruticosa-and-angelica-dahurica-against-mptp-induced-neurotoxicity-via-regulation-of-nuclear-receptor-related-1-protein
#3
Yeomoon Sim, Gunhyuk Park, Hyeyoon Eo, Eugene Huh, Pil Sung Gu, Seon-Pyo Hong, Youngmi Kim Pak, Myung Sook Oh
Parkinson's disease (PD) is one of the progressive neurodegenerative diseases of whose condition is characterized by dopaminergic neuronal cell loss and dysfunction in the substantia nigra pars compacta (SNpc) and the striatum. Recent studies have demonstrated that the nuclear receptor-related 1 protein (Nurr1) is critical of dopaminergic phenotype induction in mesencephalic dopaminergic neurons. Further, Nurr1 engages in synthesizing and storing dopamine through regulating levels of tyrosine hydroxylase (TH), dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2)...
October 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/27693772/toxic-polyacetylenes-in-the-genus-bupleurum-apiaceae-distribution-toxicity-molecular-mechanism-and-analysis
#4
Meiyu Lin, Weidong Zhang, Juan Su
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Bupleurum includes approximately 200 species that are widely distributed in the Northern Hemisphere, Eurasia and North Africa. Certain species of this genus have long been used as antiphlogistic, antipyretic and analgesic agents in traditional folk medicine. As described in the Chinese Pharmacopoeia, the roots of Bupleurum chinense DC. and B. scorzonerifolium Willd. are the herbal materials that compose Chaihu (Radix Bupleuri), a well-known TCM herb...
September 29, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27649745/antioxidant-and-cytotoxic-lignans-from-the-roots-of-bupleurum-chinense
#5
Dan-Qi Li, Di Wang, Le Zhou, Ling-Zhi Li, Qing-Bo Liu, Ying-Ying Wu, Jing-Yu Yang, Shao-Jiang Song, Chun-Fu Wu
In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8-O-4' neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2-9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and cytotoxic effects of isolated compounds were evaluated in vitro. The isolated compounds (IC50 > 200 μM) did not display 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity...
September 21, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27599678/vinegar-amount-in-the-process-affected-the-components-of-vinegar-baked-radix-bupleuri-and-its-hepatoprotective-effect
#6
Ya Zhao, Yin-Jie Wang, Rui-Zhi Zhao, Fei-Jun Xiang
BACKGROUND: Bupleuri Radix (in Chinese Chaihu), the dried roots of Bupleurum Chinense DC, is a traditional Chinese medicine widely used to treat fever, hepatitis, jaundice, nephritis, dizziness. When baked with vinegar, its effect is more focused on liver related disease. This paper was undertaken to determine the best vinegar amount in the processing and explore its key efficacy components. METHODS: Hepatoprotective effects of Radix Bupleuri after processing with different amount of vinegar (1:5, 2:5, 3:5) were investigated on liver hurt rats, and the change of constituents were analyzed by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27461108/saikosaponin-d-induces-cell-death-through-caspase-3-dependent-caspase-3-independent-and-mitochondrial-pathways-in-mammalian-hepatic-stellate-cells
#7
Ming-Feng Chen, S Joseph Huang, Chao-Cheng Huang, Pei-Shan Liu, Kun-I Lin, Ching-Wen Liu, Wen-Chuan Hsieh, Li-Yen Shiu, Chang-Han Chen
BACKGROUND: Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, cell cycle arrest and apoptosis induction in several cancer cell lines. However, the biological functions and molecular mechanisms of mammalian cells under SSd treatment are still unclear. METHODS: The cytotoxicity and apoptosis of hepatic stellate cells (HSCs) upon SSd treatment were discovered by MTT assay, colony formation assay and flow cytometry...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27353866/contributions-to-the-phytotherapies-of-digestive-disorders-traditional-knowledge-and-cultural-drivers-of-manoor-valley-northern-pakistan
#8
Inayat Ur Rahman, Farhana Ijaz, Aftab Afzal, Zafar Iqbal, Niaz Ali, Shujaul Mulk Khan
ETHNO PHARMACOLOGICAL RELEVANCE: Ethno medicinal traditional knowledge regarding the uses of indigenous medicinal plants used for various human digestive disorders are mostly known to the elder community members. As the young generation is not much aware about such vital traditional medicinal practice because they rely on elders. AIM OF STUDY: To document, accumulate and widely disseminate the massive indigenous knowledge of century's practiced therapeutic uses of medicinal plants by the local people living in this remote area...
June 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27187480/the-complete-chloroplast-genome-of-the-hare-s-ear-root-bupleurum-falcatum-its-molecular-features
#9
Dong-Ho Shin, Jeong-Hoon Lee, Sang-Ho Kang, Byung-Ohg Ahn, Chang-Kug Kim
Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure. The Apiaceae family is taxonomically close to the Araliaceae family and there have been numerous complete chloroplast genome sequences reported in the Araliaceae family, while little is known about the Apiaceae family...
2016: Genes
https://www.readbyqxmd.com/read/27180317/multicomponent-multitarget-integrated-adjustment-metabolomics-study-of-qizhiweitong-particles-curing-gastrointestinal-motility-disorders-in-mice-induced-by-atropine
#10
Xin Chang, Shuai Wang, Yong-Rui Bao, Tian-Jiao Li, Xiao-Meng Yu, Xian-Sheng Meng
ETHNOPHARMACOLOGICAL RELEVANCE: Qizhiweitong particles (QZWT) which is derived from the Sinisan decoction in Shang Han Za Bing Lun, composed of Bupleurum chinenis, Paeonia obovata, Citrus aurantium L., Glycyrrhiza uralensis Fisch., Cyperus rotundus and Rhizoma Corydalis is a traditional Chinese medicine (TCM) treating gastrointestinal diseases. It have been used in clinical for years. It have been used in clinical for years. According to previous research, Bupleurum chinenis, Citrus aurantium, Cyperus rotundus in QZWT play the role of promoting gastric peristalsis, which consist of complex chemical constituents...
August 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27144658/role-of-5-saponins-in-secretion-of-cytokines-by-prrsv-induced-endothelial-cells
#11
Y Hu, A Mao, Y Tan, Y Zhao, K He
The aim of the research presented here was to investigate the immunoloregulatory effects of 5 saponins: Saikosaponins A (SSA) and D (SSD) from Bupleurum chinese DC (Umbelliferae), Panax Notoginseng Saponin (PNS) and Notoginsenoside R1 from Panax notoginseng (Araliaceae) (SR1), and Anemoside B4 from Pulsatilla chinensis Regel (Ranunculaceae) (AB4). To achieve this, endothelial cells were challenged with 10(5) TCID50/mL PRRSV for 24 h then treated respectively with 5 saponins at 3 concentrations (1, 5 and 10 μg/mL)...
July 2016: Drug Research
https://www.readbyqxmd.com/read/27080427/reducing-effect-of-saikosaponin-a-an-active-ingredient-of-bupleurum-falcatum-on-alcohol-self-administration-in-rats-possible-involvement-of-the-gabab-receptor
#12
Paola Maccioni, Irene Lorrai, Mauro A M Carai, Antonella Riva, Paolo Morazzoni, Claudia Mugnaini, Federico Corelli, Gian Luigi Gessa, Giancarlo Colombo
Recent studies demonstrated that treatment with saikosaponin A (SSA) - an active ingredient of the medicinal herb, Bupleurum falcatum L. - selectively suppressed, likely via a GABAB receptor-mediated mechanism, intravenous self-administration of morphine and cocaine in rats [Yoon et al., 2012; 2013]. The present study was designed to investigate whether the capacity of SSA to suppress morphine and cocaine self-administration extends to oral alcohol self-administration. To this end, selectively bred Sardinian alcohol-preferring (sP) rats were trained to lever-respond on a Fixed Ratio (FR) 4 (FR4) schedule of reinforcement for alcohol (15%, v/v) in daily 30-min sessions...
May 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26996033/chemical-composition-of-the-essential-oil-of-bupleurum-fontanesii-apiaceae-growing-wild-in-sicily-and-its-activity-on-microorganisms-affecting-historical-art-crafts
#13
Simona Casiglia, Maurizio Bruno, Federica Senatore, Felice Senatore
Hydrodistillation of the flowers (BpFI) of and fruits (BpFr) of Bupleurumfontanesii Guss. ex Caruel gave two oils that were analyzed by GC and GC-MS. The main components were α-elemol (16.7%), caryophyllene oxide (16.4%) and heptacosane (15.9%) in BpFl, and spathulenol (16.8%), caryophylladienol I (13.2%) and α-elemol (12.8%) in BpFr. A good antimicrobial activity against several microorganisms, including Bacillus subtilis, Staphylococcus aureus, Fusarium oxysporum and Aspergillus niger, all infesting historical art craft, was also determined...
January 2016: Natural Product Communications
https://www.readbyqxmd.com/read/26983230/-evaluation-for-merchandise-character-and-quality-of-bupleurum-chinense-root-from-different-habitats
#14
Ai-nong Cao, Ming Fan, Duo Lv, Xiao-jun Jin, Guo-qin Li, Xian-long Lu
OBJECTIVE: To evaluate the merchandise character and quality of Bupleurum chinense root from different habitats. METHODS: The spectrophotometer method was used to determine the content of total saponins and total flavonoids in Bupleurum chinense root. The content of alcohol-soluble extract and total ash were determined according to the method in the Chinese Pharmacopoeia. RESULTS: The quality of Bupleuri Radix from different habitats varied greatly...
August 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/26970984/uflc-ms-ms-determination-and-pharmacokinetic-studies-of-six-saikosaponins-in-rat-plasma-after-oral-administration-of-bupleurum-dropping-pills
#15
Xiufeng Guan, Xiangyang Wang, Kaijing Yan, Yang Chu, Shuming Li, Wei Li, Xueying Yan, Xiaohui Ma, Shuiping Zhou, He Sun, Changxiao Liu
A rapid and sensitive ultra fast liquid chromatography tandem mass spectrometry method (UFLC-MS/MS) was developed and validated for the simultaneous determination of six Saikosaponins (SSs) (SSa, SSb1, SSb2, SSd, SSc, SSf) of Bupleurum Dropping Pills (BDP) in rat plasma using chloramphenicol as the internal standard (IS). The SSs were separated using an ACQUITY UPLC(®) BEH C18 column (50 mm × 2.1mm, 1.7 μm) and detection of these compounds were done by using a Qtrap 5500 mass spectrometer coupled with negative electrospray ionization (ESI) source under the multiple reaction monitoring (MRM) mode...
May 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26961382/saikosaponin-d-reduces-h2o2-induced-pc12-cell-apoptosis-by-removing-ros-and-blocking-mapk-dependent-oxidative-damage
#16
Xuemei Lin, Songdi Wu, Qing Wang, Yaling Shi, Guozheng Liu, Jin Zhi, Fang Wang
Neuronal oxidative stress (OS) injury has been proven to be associated with many neurodegenerative diseases, and thus, antioxidation treatment is an effective method for treating these diseases. Saikosaponin-D (SSD) is a sapogenin extracted from Bupleurum falcatum and has been shown to have many pharmacological activities. The main purpose of this study was to investigate whether and how SSD protects PC12 cells from H2O2-induced apoptosis. The non-toxic level of SSD significantly mitigated the H2O2-induced decrease in cell viability, reduced the apoptosis rate, improved the nuclear morphology, and reduced caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage...
March 9, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/26905227/anti-inflammatory-actions-of-3-%C3%AE-angeloxy-4-keto-3-4-dihydroseselin-pd-ib-against-dextran-sulfate-sodium-induced-colitis-in-c57bl-6-mice
#17
Huai-Xue Mu, Jing Liu, Sarwat Fatima, Cheng-Yuan Lin, Xiao-Ke Shi, Bin Du, Hai-Tao Xiao, Bao-Min Fan, Zhao-Xiang Bian
The immunoregulatory protective properties of (+)-3'α-angeloxy-4'-keto-3',4'-dihydroseselin (Pd-Ib) isolated from Bupleurum malconense has not been reported. In the present study, the therapeutic effect of Pd-Ib (30, 60, and 120 mg/kg/day) was examined in a mouse model of dextran sulfate sodium (DSS)-induced acute colitis. Administration of Pd-Ib significantly reduced the disease activity index, inhibited the shortening of colon length, reduced colonic tissue damage, and suppressed colonic myeloperoxidase activity and nitric oxide levels in mice with DSS-induced colitis...
April 22, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/26883148/neuroprotective-oleanane-triterpenes-from-the-roots-of-bupleurum-chinense
#18
Dan-Qi Li, Le Zhou, Di Wang, Jie Wu, Ling-Zhi Li, Xiao-Xiao Huang, Qing-Bo Liu, Ying-Ying Wu, Song Lin, Jing-Yu Yang, Shao-Jiang Song, Chun-Fu Wu
The discovery of new natural compounds with pharmacological properties is an increasingly important field, and a continuous phytochemical investigation of the roots of Bupleurum chinense D.C. has led to the isolation of 17 triterpenoids, including three new oleanane triterpenes (1-3) together with 14 known ones. Their structures were determined on the basis of 1D and 2D NMR spectra as well as HR-ESI-MS data. The cytotoxicities of all compounds against five selected human cancer cell lines were assayed. Only compounds 9 and 14 exhibited moderate activities...
March 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/26877763/a-novel-coumarin-3-angeloxyloxy-4-keto-3-4-dihydroseselin-isolated-from-bupleurum-malconense-chaihu-inhibited-nf-%C3%AE%C2%BAb-activity
#19
Huai-Xue Mu, Cheng-Yuan Lin, Lin-Fang Huang, Da-Jian Yang, Ai-Ping Lu, Quan-Bin Han, Zhao-Xiang Bian
BACKGROUND: This study aims to identify the major anti-inflammatory components in the petroleum ether extract of Bupleurum malconense (Chaihu), by bioassay-guided fractionation, and to investigate the anti-inflammatory mechanisms of active components in lipopolysaccharide (LPS)-stimulated murine macrophage RAW-Blue cells. METHODS: A QUANTI-Blue assay was used to guide fractionation of B. malconense root extract. The petroleum ether extract which exerted significant secreted embryonic alkaline phosphatase (SEAP) inhibition effect was purified by silica gel column chromatography and assisted with reverse phase HPLC...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/26748071/anti-melanoma-activity-of-bupleurum-chinense-bupleurum-kaoi-and-nanoparticle-formulation-of-their-major-bioactive-compound-saikosaponin-d
#20
Stephen Chu-Sung Hu, I-Ta Lee, Ming-Hong Yen, Chun-Ching Lin, Chiang-Wen Lee, Feng-Lin Yen
ETHNOPHARMACOLOGICAL RELEVANCE: Bupleurum chinense is a traditional Chinese medicinal herb which has been used to treat various inflammatory and infectious diseases, while Bupleurum kaoi is an endemic plant in Taiwan. We determined whether B. chinense and B. kaoi and their biologically active saikosaponin compounds possess anti-melanoma activity. In addition, we developed a novel saikosaponin-d nanoparticle system to improve its solubility, and evaluated its antiproliferative effects and molecular mechanisms in melanoma cells...
February 17, 2016: Journal of Ethnopharmacology
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