keyword
https://read.qxmd.com/read/38509892/interval-based-sparse-ensemble-multi-class-classification-algorithm-for-terahertz-data
#1
JOURNAL ARTICLE
Chengyong Zheng, Xiaowen Zha, Shengjie Cai, Jing Cui, Qian Li, Zhijing Ye
Terahertz time-domain spectroscopy (THz-TDS) has been widely used for food and drug identification. The classification information of a THz spectrum usually does not exist in the whole spectral band but exists only in one or several small intervals. Therefore, feature selection is indispensable in THz-based substance identification. However, most THz-based identification methods empirically intercept the low-frequency band of the THz absorption coefficients for analysis. In order to adaptively find out important intervals of the THz spectra, an interval-based sparse ensemble multi-class classifier (ISEMCC) for THz spectral data classification is proposed...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38479544/homotherapy-for-heteropathy-of-bupleurum-chinense-dc-scutellaria-baicalensis-georgi-in-treating-depression-and-colorectal-cancer-a-network-pharmacology-and-animal-model-approach
#2
JOURNAL ARTICLE
Ruolan Sun, Yan Liang, Shijiao Zhu, Qihang Yin, Yong Bian, Hongyue Ma, Fan Zhao, Gang Yin, Decai Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Bupleurum chinense DC.-Scutellaria baicalensis Georgi (BS) is a classic drug pair that has good clinical effects on depression and many tumors. However, the concurrent targeting mechanism of how the aforementioned drug pair is valid in the two distinct diseases, has not been clarified yet. AIM OF THE STUDY: The components of BS were detected by LC-MS, combined with network pharmacology to explore the active ingredients and common targeting mechanism of its multi-pathway regulation of BS in treating depression and CRC, and to validate the dual effects of BS using the CUMS mice model and orthotopic transplantation tumor mice model of CRC...
March 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38397550/the-contribution-of-botanical-origin-to-the-physicochemical-and-antioxidant-properties-of-algerian-honeys
#3
JOURNAL ARTICLE
Sonia Harbane, Olga Escuredo, Yasmine Saker, Asma Ghorab, Rifka Nakib, María Shantal Rodríguez-Flores, Akli Ouelhadj, María Carmen Seijo
Honeys from different regions of Algeria were analyzed to determine their pollen characteristics and physicochemical properties (humidity, pH, electrical conductivity, diastase content, color, phenols, flavonoids and antioxidant activity). The antioxidant activity was investigated using the free radical scavenging and Ferric reducing/antioxidant power assays. The melissopalynological analysis revealed 129 pollen types from 53 botanical families. The pollen types found as dominant were Coriandrum , Bupleurum , Brassica napus type, Hedysarum coronarium , Ceratonia siliqua , Eucalyptus , Peganum harmala , Ziziphus lotus and Tamarix ...
February 14, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38327157/the-effect-of-jian-gan-powder-on-the-proliferation-migration-and-polarization-of-macrophages-and-relative-mechanism
#4
JOURNAL ARTICLE
Kun Li, Xue Zheng, Jian Zhang, Zhanpeng Yan, Yu Ji, Fei Ge, Fangshi Zhu
CONTEXT: Jian Gan powder (JGP) is a Chinese medicine compound comprised ginseng, Radix Paeoniae Alba, Radix Astragali, Salvia miltiorrhiza, Yujin, Rhizoma Cyperi, Fructus aurantii, Sophora flavescens, Yinchen, Bupleurum and licorice. OBJECTIVE: This study explored the inhibitory effects, polarization and potential mechanisms associated with JGP in macrophages. MATERIALS AND METHODS: RAW264.7 cells were randomly divided into six groups for 24 h: control, lipopolysaccharide (LPS), overexpression, 1% JGP, 2% JGP, 4% JGP, 8% JGP and 16% JGP...
December 2024: Pharmaceutical Biology
https://read.qxmd.com/read/38315576/gc-ms-analysis-of-essential-oil-from-the-leaves-of-algerian-bupleurum-plantagineum-desf
#5
JOURNAL ARTICLE
Smaili Tahar, Bendif Hamdi, Gregorio Peron, Ghadbane Mouloud, Rebbas Khellaf, Zellagui Amar, Flamini Guido
Bupleurum plantagineum Desf. (Apiaceae) is a plant endemic to North Africa, including Algeria. It is used as natural medicine, due to its anti-inflammatory, antioxidant and hepatoprotective properties. In this work, we studied the chemical composition of the essential oil (EO) obtained by hydro-distillation from B. plantagineum leaves collected from the national park of Gouraya (Bejaïa), Algeria. Thirty components were identified in the EO by Gas chromatography-Mass Spectrometry(GC-MS) (relative abundance: 96...
February 5, 2024: Natural Product Research
https://read.qxmd.com/read/38217462/two-omics-methods-expose-anti-depression-mechanism-of-raw-and-vinegar-baked-bupleurum-scorzonerifolium-%C3%A2-willd
#6
JOURNAL ARTICLE
Xiang Zou, Zhongyuan Qu, Yan Zheng, Shuang Wu, Yifan Bing, Zhiwei Sun, Shiru Zhu, Wenlan Li
Bupleurum scorzonerifolium willd. (BS) and its vinegar-baked product (VBS) has been frequently utilized for depression management in clinical Chinese medicine. This paper aims to elucidate the antidepressant mechanism of BS and VBS from the perspectives of metabonomics and gut microbiota. A rat model of depression was established by CUMS combined with feeding alone to evaluate the antidepressant effects of BS and VBS. UPLC-Q-TOF-MS/MS-based metabolomics and 16S rRNA sequencing of rat feces were applied and the correlation of differential metabolic markers and intestinal floras was analyzed...
January 13, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38142618/matlab-language-assisted-data-acquisition-and-processing-in-liquid-chromatography-orbitrap-mass-spectrometry-application-to-the-identification-and-differentiation-of-radix-bupleuri-from-its-adulterants
#7
JOURNAL ARTICLE
Xuan-Jing Shen, Jian-Qing Zhang, Ya-Ling An, Lin Yang, Xiao-Lan Li, Yun-Shu Hu, Fei Sha, Chang-Liang Yao, Qi-Rui Bi, Hua Qu, De-An Guo
Comprehensive and rapid analysis of secondary metabolites like saponins remains challenging. This study aimed to establish a semi-automated workflow for filtration, identification, and characterization of saikosaponins in six Bupleurum species. Radix Bupleuri, a high-sales herbal medicine, is often adulterated, restricting its quality control and applications. Two authentic Radix Bupleuri species and four major adulterants were analyzed through UHPLC-LTQ-Orbitrap-MS for targeted saikosaponin analysis. To reveal trace saikosaponins and obtain quality fragment data, a MATLAB-based process automatically enumerating "sugar chain + aglycone + side chain" combinations and deduplicating generated a predicted saikosaponin database covering all possible saikosaponins as a precursor ion list for comprehensive targeted acquisition...
December 13, 2023: Journal of Chromatography. A
https://read.qxmd.com/read/38128620/transcriptome-analysis-of-the-mechanism-of-endophytic-fungus-chs3-promoting-saikosaponin-d-synthesis-in-bupleurum-scorzonerifolium-willd-suspension-cells
#8
JOURNAL ARTICLE
Yupeng Cheng, Yuanzhen Liu, Xinhong Li, Guangjie Liu, Zhongmeng Li, Bo Liu, Ning Gao
Saikosaponin d (SSd) is the main component of Bupleuri Radix, a famous traditional Chinese herbal medicine, with high medicinal value. An endophytic fungus (CHS3) was isolated from Bupleurum scorzonerifolium Willd. in the early stage of our research, and we found that CHS3 could promote the accumulation of SSd in Bupleurum scorzonerifolium Willd. suspension cells (BSS cells). It is of practical significance to identify the mechanism that CHS3 promoted the accumulation of SSd and increased the production of SSd in suspension cells...
December 19, 2023: Fitoterapia
https://read.qxmd.com/read/38115283/a-real-world-data-analysis-based-study-of-chinese-medicine-treatment-patterns-after-breast-cancer-surgery
#9
JOURNAL ARTICLE
Lvhui Hu, Yi Yang, Zhiwen Wang, Chuanbiao Wen, Xiaoen Cheng
Based on the real clinical data of Hospital Information System to explore the common clinical syndromes of traditional Chinese medicine after breast cancer surgery, analysis of traditional Chinese medicine in the treatment of breast cancer after the compatibility law. The real medical records of breast cancer patients after surgery in a tertiary hospital in Sichuan Province were collected and screened to build a medical record database. Python language was used for data preprocessing to remove outliers and fill in missing values...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38089791/phylogenomic-analysis-of-bupleurum-in-western-sichuan-china-including-an-overlooked-new-species
#10
JOURNAL ARTICLE
Zhi Chao, Xiaoxi Hong, Xuena Xie, Rong Huang, Enwei Tian
A comparative analysis of chloroplast (cp) genomes and 45s nuclear ribosomal DNA (nrDNA), and a phylogenomic study of six closely related species (including an overlooked new species) of genus Bupleurum from the western part of Sichuan Province in southwestern China were performed. The six species are similar morphologically and it is difficult to identify them; moreover, their genetic relationships remain unclear. It was found that the cp genomes of the six Bupleurum species were extremely similar, and they were highly homogeneous in terms of cp genome structure, genes and its arrangement...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/38070467/saikosaponin-d-alleviates-depression-by-promoting-nlrp3-ubiquitination-and-inhibiting-inflammasome-activation
#11
JOURNAL ARTICLE
Tiantian Gao, Tao Wang, Lili Wu, Yue Tong, Jinlong Tian, Keke Zhao, Hanqing Wang
Saikosaponin-d (SSd) is a triterpene saponin from the roots of Bupleurum chinese. Recent studies have revealed its antidepressant activity, but its mechanism involved is unclear. This study's objective was to ascertain how SSd may reduce depression in depressed mice subjected to chronic unpredictable animal stress (CUMS) and to investigate the mechanisms underlying these effects. Models of CUMS depression were established and different groups were treated with SSd and escitalopram. After the last day of administration of the treatment, behavioral tests were performed...
December 8, 2023: International Immunopharmacology
https://read.qxmd.com/read/38039833/bupleurum-exerts-antiarrhythmic-effects-by-inhibiting-l-type-calcium-channels-in-mouse-ventricular-myocytes
#12
JOURNAL ARTICLE
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
BACKGROUND: Bupleurum (Bup), is a traditional effective medicine to treat colds and fevers in clinics. Multiple studies have demonstrated that Bup exhibites various biological activities, including cardioprotective effects, anti-inflammatory, anticancer, antipyretic, antimicrobial, and antiviral effects, etc. Currently, the effects of Bup on cardiac electrophysiology have not been reported yet. METHODS: Electrocardiogram recordings were used to investigate the effects of Bup on aconitine-induced arrhythmias...
November 25, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37844745/saikosaponin-a-activates-tet1-dll3-notch1-signalling-and-promotes-hippocampal-neurogenesis-to-improve-depression-like-behavior-in-mice
#13
JOURNAL ARTICLE
Yue Tong, Ge Zhao, Ruonan Shuang, Hanqing Wang, Nan Zeng
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Bupleuri, also named "Chaihu" in Chinese, is a substance derived from the dry roots of Bupleurum chinense DC. [Apiaceae] and Bupleurum scorzonerifolium Willd. [Apiaceae]. Radix Bupleuri was initially recorded as a medicinal herb in Shen Nong Ben Cao Jing, the earliest monograph concerning traditional Chinese medicine (TCM). Ever since, Radix Bupleuri has been broadly used to alleviate exterior syndrome, disperse heat, modulate the liver-qi, and elevate yang-qi in TCM...
October 14, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37837833/saikosaponin-d-regulates-angiogenesis-in-idiopathic-pulmonary-fibrosis-through-angiopoietin-tie-2-pathway
#14
JOURNAL ARTICLE
Yan Wu, Jun Zhang, Xintian Wang, Yuncong Xu, Jinxu Zheng
OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) is considered as a chronic interstitial lung disease with underlying mechanism of IPF remaining unclear, while there are no definitive treatment options. In recent years, scientists have gradually paid attention to the influence of angiogenesis on IPF. Because IPF is a progressive with microvascular remodeling disorder, scientists have postulated that angiogenesis may also be one of the initiating and contributing factors of the disease. Bupleurum is a common natural Chinese herbal medicine with antibacterial, anti-inflammatory, anti-tumor and other pharmacological effects...
October 12, 2023: Acta Histochemica
https://read.qxmd.com/read/37804411/highly-sensitive-indirect-competitive-enzyme-linked-immunosorbent-assay-based-on-a-monoclonal-antibody-against-saikosaponin-b2-for-quality-control-of-kampo-medicines-containing-bupleuri-radix
#15
JOURNAL ARTICLE
Akihiro Ochi, Shunsuke Fujii, Tomoe Ohta, Takuhiro Uto, Poomraphie Nuntawong, Hiroyuki Tanaka, Satoshi Morimoto, Seiichi Sakamoto
Saikosaponins are naturally occurring oleanane-type triterpenoids that are found in Bupleuri radix (root of Bupleurum falcatum) and exhibit a broad biological activity spectrum. Saikosaponin b2 (SSb2) is the main saikosaponin in Kampo medicine extracts and is a designated quality control marker for the same in the Japanese Pharmacopeia. Although some monoclonal antibodies (mAbs) against saikosaponins have been produced to evaluate the quality of Bupleuri radix and related products, anti-SSb2 mAbs have not been used to quantify SSb2 in Kampo medicines...
October 7, 2023: Journal of Natural Medicines
https://read.qxmd.com/read/37787024/discovery-and-verification-of-anti-inflammatory-related-quality-markers-in-the-aerial-part-of-bupleurum-scorzonerifolium-by-uplc-q-tof-ms-ms-and-in-raw-264-7-cells-and-a-zebrafish-model
#16
JOURNAL ARTICLE
Su-Nan Li, Yi-Fan Bing, Shuang Wu, Long-Tan Luo, Zhi-Wei Sun, Wen-Lan Li, Zhong-Yuan Qu, Xiang Zou
INTRODUCTION: The root of Bupleurum scorzonerifolium Willd. (BS) is officially recognized in the Chinese Pharmacopoeia. In contrast, the aerial part of BS (ABS), accounting for 80% of BS, is typically discarded, causing potential waste of medicinal resources. ABS has shown benefits in the treatment of inflammation-related diseases in China and Spain, and the material basis underlying its anti-inflammatory effects must be systematically elucidated for the rational use of ABS. OBJECTIVE: We aimed to screen and validate the anti-inflammatory quality markers (Q-markers) of ABS and to confirm the ideal time for ABS harvesting...
October 3, 2023: Phytochemical Analysis: PCA
https://read.qxmd.com/read/37644785/saikosaponin-a-alleviates-staphylococcus-aureus-induced-mastitis-in-mice-by-inhibiting-ferroptosis-via-sirt1-nrf2-pathway
#17
JOURNAL ARTICLE
Lihua Zhao, Lei Jin, Bin Yang
Mastitis is a common and serious bacterial infection of the mammary gland. Saikosaponin A (SSA) is a triterpenoid saponin isolated from Bupleurum falcatum that has the ability to treat various diseases. However, little is known about the role of SSA in achieving mastitis remission. Here, we found that SSA alleviated Staphylococcus aureus (S. aureus)-induced mastitis by attenuating inflammation and maintaining blood-milk barrier integrity. Furthermore, S. aureus activated nuclear factor kappa B (NF-κB) pathway by upregulated p-p65 and p-IκB...
August 29, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37622271/leaf-spot-caused-by-didymella-glomerata-on-chaihu-bupleurum-falcatum-l-in-china
#18
JOURNAL ARTICLE
Tao Tang, Fanfan Wang, Jie Guo, XiaoLiang Guo, Yuanyuan Duan, Jingmao You
Bupleurum falcatum is a Apiaceae family herbal medicinal plant, which has the functions of soothing liver, relieving depression, relieving fever, dispelling stagnation, and regulating menstruation. B. falcatum roots have been used in Chinese herbal formbulary for at least 2000 years (Ahmadimoghaddam et al. 2021). In June 2021, infected leaves of B. falcatum that had dark brown, circular, elliptical or irregular shaped lesions or severely withered were obtained in Yichang (30.75 ° N,111.24 ° E), Hubei, China...
August 25, 2023: Plant Disease
https://read.qxmd.com/read/37570602/quantitative-and-differential-analysis-between-bupleurum-chinense-dc-and-bupleurum-scorzonerifolium-willd-using-hplc-ms-and-gc-ms-coupled-with-multivariate-statistical-analysis
#19
JOURNAL ARTICLE
Zhenhuan Wang, Lu Tian, Yusheng Xiao, Mengya Zhao, Yanyan Chang, Yujiang Zhou, Shuying Liu, Huanxi Zhao, Yang Xiu
Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. have different clinical efficacies, with the former typically used to treat typhoid fever and the latter mainly used to clear liver heat. The differences in their clinical efficacy are closely related to their complex chemical composition, especially the active components. In this study, the saponins and volatile oils in two varieties of Radix Bupleuri grown in different regions were extracted and analyzed using high-performance liquid chromatography (HPLC) and gas chromatography coupled with mass spectrometry (MS), and the absolute contents of five saikosaponins were accurately quantified using an established HPLC-MS method in the multiple reaction monitoring mode...
July 25, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37433245/saikosaponin-d-modulates-the-polarization-of-tumor-associated-macrophages-by-deactivating-the-pi3k-akt-mtor-pathway-in-murine-models-of-pancreatic-cancer
#20
JOURNAL ARTICLE
Xinsheng Xu, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, Caixia Li
The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) poses a major obstacle to traditional and immunomodulatory cancer therapies and is closely associated with macrophage polarization. Saikosaponin d (SSd), a major active component of triterpene saponins derived from Bupleurum falcatum, has anti-inflammatory and antitumor activities. However, whether SSd can regulate immune cells during the development of the TME in PDAC remains unknown. In the present study, we aimed to analyze the role of SSd in regulating immune cells in the PDAC TME, especially the polarization of macrophages, and examine the related mechanisms...
July 9, 2023: International Immunopharmacology
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