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James gibson

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https://www.readbyqxmd.com/read/27905186/severe-asthma-current-management-targeted-therapies-and-future-directions-a-roundtable-report
#1
REVIEW
Vanessa M McDonald, Steven Maltby, Helen K Reddel, Gregory G King, Peter A B Wark, Lorraine Smith, John W Upham, Alan L James, Guy B Marks, Peter G Gibson
Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway inflammation, airway obstruction and airway hyper-responsiveness. Asthma is common and directly affects 10% of Australians, 1-5% of adults in Asia and 300 million people worldwide. It is a heterogeneous disorder with many clinical, molecular, biological and pathophysiological phenotypes. Current management strategies successfully treat the majority of patients with asthma who have access to them. However, there is a subset of an estimated 5-10% of patients with asthma who have severe disease and are disproportionately impacted by symptoms, exacerbations and overall illness burden...
November 30, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27899642/the-ucsc-genome-browser-database-2017-update
#2
Cath Tyner, Galt P Barber, Jonathan Casper, Hiram Clawson, Mark Diekhans, Christopher Eisenhart, Clayton M Fischer, David Gibson, Jairo Navarro Gonzalez, Luvina Guruvadoo, Maximilian Haeussler, Steve Heitner, Angie S Hinrichs, Donna Karolchik, Brian T Lee, Christopher M Lee, Parisa Nejad, Brian J Raney, Kate R Rosenbloom, Matthew L Speir, Chris Villarreal, John Vivian, Ann S Zweig, David Haussler, Robert M Kuhn, W James Kent
Since its 2001 debut, the University of California, Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu/) team has provided continuous support to the international genomics and biomedical communities through a web-based, open source platform designed for the fast, scalable display of sequence alignments and annotations landscaped against a vast collection of quality reference genome assemblies. The browser's publicly accessible databases are the backbone of a rich, integrated bioinformatics tool suite that includes a graphical interface for data queries and downloads, alignment programs, command-line utilities and more...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27860360/homozygous-variants-in-pyrroline-5-carboxylate-reductase-2-pycr2-in-patients-with-progressive-microcephaly-and-hypomyelinating-leukodystrophy
#3
Linyan Meng, Taraka Donti, Fan Xia, Zhiyv Niu, Aisha Al Shamsi, Jozef Hertecant, Fatma Al-Jasmi, James B Gibson, Honey Nagakura, Jing Zhang, Weimin He, Christine Eng, Yaping Yang, Sarah H Elsea
Pyrroline-5-carboxylate reductase 2, encoded by PYCR2, is one of the three homologous enzymes that catalyze the last step of proline synthesis. Homozygous variants in PYCR2 have been reported in patients from multiple consanguineous families with hypomyelinating leukodystrophy 10 (HLD10) (MIM: 616420). Here, we report five additional patients from three families with homozygous nonsense or missense variants in PYCR2, identified through clinical exome sequencing. All patients presented with postnatally acquired microcephaly, moderate to profound global developmental delay, and failure to thrive...
November 11, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27859217/feeling-one-s-way-in-the-world-making-a-life
#4
Margaret M Browning
This paper argues for the psychoanalytic relevance of the works of James Gibson and Susanne Langer in explicating the early development of the human child and makes use of this combined formulation of development to think about psychoanalytic theory and practice. From the insights of James Gibson's ecological psychology we can appreciate the embodiment and embeddedness of the child's growing mind within both her physical and social environments. Making use of Susanne Langer's concept of feeling to redefine ecological psychology's perceptual counterpart to action allows us to understand the child's seamless transition into active participation in her culture, as she learns to project her animalian capacity to feel into intersubjectively defined forms of behavior and experience with others...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27842872/first-detection-of-extended-spectrum-cephalosporin-and-fluoroquinolone-resistant-escherichia-coli-in-australian-food-producing-animals
#5
Sam Abraham, David Jordan, Hui S Wong, James R Johnson, Mark A Toleman, David L Wakeham, David M Gordon, John D Turnidge, Joanne L Mollinger, Justine S Gibson, Darren J Trott
This study aimed to define the frequency of resistance to critically important antimicrobials (CIAs) [i.e. extended-spectrum cephalosporins (ESCs), fluoroquinolones (FQs) and carbapenems] among Escherichia coli isolates causing clinical disease in Australian food-producing animals. Clinical E. coli isolates (n=324) from Australian food-producing animals [cattle (n=169), porcine (n=114), poultry (n=32) and sheep (n=9)] were compiled from all veterinary diagnostic laboratories across Australia over a 1-year period...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27823698/a-critical-reappraisal-of-aspirin-for-secondary-prevention-in-patients-with-ischemic-heart-disease
#6
REVIEW
Robert C Welsh, Matthew T Roe, Philippe Gabriel Steg, Stefan James, Thomas J Povsic, Christoph Bode, Charles Michael Gibson, Erik Magnus Ohman
Aspirin was established more than a quarter century ago as an evidence-based therapy to reduce recurrent cardiovascular events in patients with coronary artery disease based on limited data by contemporary standards. Indeed it is unclear how regulatory agencies would define the optimal dose or duration of aspirin therapy if assessed in the current era. Subsequent clinical investigation has focused on the addition of antithrombotic agents on top of baseline aspirin therapy in the acute and chronic setting to reduce patient's risk of further ischemic events, at the cost of increased bleeding complications...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27820931/when-clinical-trial-participation-is-not-an-option-in-the-era-of-personalized-medicine-the-case-of-two-patients
#7
Claire F Verschraegen, Hibba Rehman, Bhargavi Pulluri, James DeKay, Maura Barry, Edmund Folefac, Kim Dittus, Chris Holmes, Julian Sprague, Steve Ades, Pam C Gibson
The combination of personalized therapy with immunotherapy might lead to rapid complete remission in patients who are too sick to be eligible for clinical trials. We report 2 such extraordinary responders. A discussion on the use and purpose of clinical trials in this new era of very active anticancer drug discovery concludes that a paradigm shift is urgently needed.
November 8, 2016: Oncology
https://www.readbyqxmd.com/read/27812172/adult-hematology-and-clinical-chemistry-laboratory-reference-ranges-in-a-zimbabwean-population
#8
Wadzanai P Samaneka, Gibson Mandozana, Willard Tinago, Nehemiah Nhando, Nyaradzo M Mgodi, Mutsawashe F Bwakura-Dangarembizi, Marshall W Munjoma, Zvenyika A R Gomo, Zvavahera M Chirenje, James G Hakim
BACKGROUND: Laboratory reference ranges used for clinical care and clinical trials in various laboratories in Zimbabwe were derived from textbooks and research studies conducted more than ten years ago. Periodic verification of these ranges is essential to track changes over time. The purpose of this study was to establish hematology and chemistry laboratory reference ranges using more rigorous methods. METHODS: A community-based cross-sectional study was carried out in Harare, Chitungwiza, and Mutoko...
2016: PloS One
https://www.readbyqxmd.com/read/27810558/single-ocular-injection-of-a-sustained-release-anti-vegf-delivers-6months-pharmacokinetics-and-efficacy-in-a-primate-laser-cnv-model
#9
Peter Adamson, Thomas Wilde, Eric Dobrzynski, Caroline Sychterz, Rodd Polsky, Edit Kurali, Richard Haworth, Chi-Man Tang, Justyna Korczynska, Fiona Cook, Irene Papanicolaou, Lemy Tsikna, Chris Roberts, Zoe Hughes-Thomas, James Walford, Daniel Gibson, John Warrack, Jos Smal, Ruud Verrijk, Paul E Miller, T Michael Nork, Jeffery Prusakiewicz, Timothy Streit, Steven Sorden, Craig Struble, Brian Christian, Ian R Catchpole
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing two different anti-VEGF domain antibodies (dAb) attached to a human IgG1 Fc region: a dual dAb. The delivery system is based on microparticles of PolyActive™ hydrogel co-polymer. The molecule was evaluated both in vitro for potency against VEGF and in ocular VEGF-driven efficacy models in vivo...
November 1, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27773678/heart-rate-variability-pre-deployment-predictor-of-post-deployment-ptsd-symptoms
#10
Jeffrey M Pyne, Joseph I Constans, Mark D Wiederhold, Douglas P Gibson, Timothy Kimbrell, Teresa L Kramer, Jeffery A Pitcock, Xiaotong Han, D Keith Williams, Don Chartrand, Richard N Gevirtz, James Spira, Brenda K Wiederhold, Rollin McCraty, Thomas R McCune
Heart rate variability is a physiological measure associated with autonomic nervous system activity. This study hypothesized that lower pre-deployment HRV would be associated with higher post-deployment post-traumatic stress disorder (PTSD) symptoms. Three-hundred-forty-three Army National Guard soldiers enrolled in the Warriors Achieving Resilience (WAR) study were analyzed. The primary outcome was PTSD symptom severity using the PTSD Checklist - Military version (PCL) measured at baseline, 3- and 12-month post-deployment...
October 20, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27766865/the-discovery-of-a-potent-selective-and-peripherally-restricted-pan-trk-inhibitor-pf-06273340-for-the-treatment-of-pain
#11
Sarah E Skerratt, Mark Andrews, Sharan K Bagal, James Bilsland, David Brown, Peter J Bungay, Susan Cole, Karl R Gibson, Russell Jones, Inaki Morao, Angus Nedderman, Kiyoyuki Omoto, Colin Robinson, Thomas Ryckmans, Kimberly Skinner, Paul Stupple, Gareth Waldron
The neurotrophin family of growth factors, comprised of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is implicated in the physiology of chronic pain. Given the clinical efficacy of anti-NGF monoclonal antibody (mAb) therapies, there is significant interest in the development of small molecule modulators of neurotrophin activity. Neurotrophins signal through the tropomyosin related kinase (Trk) family of tyrosine kinase receptors, hence Trk kinase inhibition represents a potentially "druggable" point of intervention...
November 4, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27766453/use-of-complementary-and-alternative-medicine-and-breast-cancer-survival-in-the-health-eating-activity-and-lifestyle-study
#12
Marian L Neuhouser, Ashley Wilder Smith, Stephanie M George, James T Gibson, Kathy B Baumgartner, Richard Baumgartner, Catherine Duggan, Leslie Bernstein, Anne McTiernan, Rachel Ballard
PURPOSE: Use of complementary and alternative medicine (CAM) is common among breast cancer patients, but less is known about whether CAM influences breast cancer survival. METHODS: Health Eating, Activity, and Lifestyle (HEAL) Study participants (n = 707) were diagnosed with stage I-IIIA breast cancer. Participants completed a 30-month post-diagnosis interview including questions on CAM use (natural products such as dietary and botanical supplements, alternative health practices, and alternative medical systems), weight, physical activity, and comorbidities...
October 21, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27697982/gastric-cancer-version-3-2016-nccn-clinical-practice-guidelines-in-oncology
#13
Jaffer A Ajani, Thomas A D'Amico, Khaldoun Almhanna, David J Bentrem, Joseph Chao, Prajnan Das, Crystal S Denlinger, Paul Fanta, Farhood Farjah, Charles S Fuchs, Hans Gerdes, Michael Gibson, Robert E Glasgow, James A Hayman, Steven Hochwald, Wayne L Hofstetter, David H Ilson, Dawn Jaroszewski, Kimberly L Johung, Rajesh N Keswani, Lawrence R Kleinberg, W Michael Korn, Stephen Leong, Catherine Linn, A Craig Lockhart, Quan P Ly, Mary F Mulcahy, Mark B Orringer, Kyle A Perry, George A Poultsides, Walter J Scott, Vivian E Strong, Mary Kay Washington, Benny Weksler, Christopher G Willett, Cameron D Wright, Debra Zelman, Nicole McMillian, Hema Sundar
Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of death from cancer in the world. Several advances have been made in the staging procedures, imaging techniques, and treatment approaches. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Gastric Cancer provide an evidence- and consensus-based treatment approach for the management of patients with gastric cancer. This manuscript discusses the recommendations outlined in the NCCN Guidelines for staging, assessment of HER2 overexpression, systemic therapy for locally advanced or metastatic disease, and best supportive care for the prevention and management of symptoms due to advanced disease...
October 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27688830/seven-step-framework-for-critical-analysis-and-its-application-in-the-field-of-physical-therapy
#14
Stephanie A Nixon, Euson Yeung, James A Shaw, Ayelet Kuper, Barbara E Gibson
Critical analysis (or the ability to recognize taken-for-granted assumptions and their effects) is a skill that requires teaching and practice. The purpose of this article is to introduce a framework for critically analyzing assumptions within physical therapy and illustrate its utility through application to 2 examples: a physical therapy clinic logo and an outcome measure for health-related quality of life (HRQOL). This 7-step framework for critical analysis was created for a pilot project to develop reflexivity among senior physical therapist students and further developed through an iterative process of reflecting on its utility for advancing the field of physical therapy...
September 29, 2016: Physical Therapy
https://www.readbyqxmd.com/read/27686458/esicm-lives-2016-part-one-milan-italy-1-5-october-2016
#15
L Bos, L Schouten, L van Vught, M Wiewel, D Ong, O Cremer, A Artigas, I Martin-Loeches, A Hoogendijk, T van der Poll, J Horn, N Juffermans, M Schultz, N de Prost, T Pham, G Carteaux, A Mekontso Dessap, C Brun-Buisson, E Fan, G Bellani, J Laffey, A Mercat, L Brochard, B Maitre, P A Howells, D R Thickett, C Knox, D P Park, F Gao, O Tucker, T Whitehouse, D F McAuley, G D Perkins, T Pham, J Laffey, G Bellani, E Fan, L Pisani, J P Roozeman, F D Simonis, A Giangregorio, L R Schouten, S M Van der Hoeven, J Horn, A Serpa Neto, E Festic, A M Dondorp, S Grasso, L D Bos, M J Schultz, M Koster-Brouwer, D Verboom, B Scicluna, K van de Groep, J Frencken, M Schultz, T van der Poll, M Bonten, O Cremer, J I Ko, K S Kim, G J Suh, W Y Kwon, K Kim, J H Shin, O T Ranzani, E Prina, R Menendez, A Ceccato, R Mendez, C Cilloniz, A Gabarrus, M Ferrer, A Torres, A Urbano, L A Zhang, D Swigon, F Pike, R S Parker, G Clermont, C Scheer, S O Kuhn, A Modler, M Vollmer, C Fuchs, K Hahnenkamp, S Rehberg, M Gründling, A Taggu, N Darang, N Öveges, I László, K Tánczos, M Németh, G Lebák, B Tudor, D Érces, J Kaszaki, W Huber, D Trásy, Z Molnár, G Ferrara, V S Kanoore Edul, H S Canales, E Martins, C Canullán, G Murias, M O Pozo, J F Caminos Eguillor, M G Buscetti, C Ince, A Dubin, H D Aya, A Rhodes, N Fletcher, R M Grounds, M Cecconi, M Jacquet-Lagrèze, M Riche, R Schweizer, P Portran, W Fornier, M Lilot, J Neidecker, J L Fellahi, A Escoresca-Ortega, A Gutiérrez-Pizarraya, L Charris-Castro, Y Corcia-Palomo, E Fernandez-Delgado, J Garnacho-Montero, C Roger, L Muller, L Elotmani, J Lipman, J Y Lefrant, J A Roberts, R Muñoz-Bermúdez, M Samper, C Climent, F Vasco, V Sara, S Luque, N Campillo, S Grau Cerrato, J R Masclans, F Alvarez-Lerma, S Carvalho Brugger, G Jimenez Jimenez, M Miralbés Torner, J Trujillano Cabello, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, M Vallverdú Vidal, M Palomar Martínez, V Gusarov, D Shilkin, M Dementienko, E Nesterova, N Lashenkova, A Kuzovlev, M Zamyatin, A Demoule, S Carreira, S Lavault, O Palancca, E Morawiec, J Mayaux, I Arnulf, T Similowski, B S Rasmussen, R G Maltesen, M Hanifa, S Pedersen, S R Kristensen, R Wimmer, M Panigada, G Li Bassi, O T Ranzani, T Kolobow, A Zanella, M Cressoni, L Berra, V Parrini, H Kandil, G Salati, S Livigni, A Amatu, A Andreotti, F Tagliaferri, G Moise, G Mercurio, A Costa, A Vezzani, S Lindau, J Babel, M Cavana, D Consonni, A Pesenti, L Gattinoni, A Torres, P Mansouri, F Zand, L Zahed, F Dehghanrad, M Bahrani, M Ghorbani, B Cambiaghi, O Moerer, T Mauri, N Kunze-Szikszay, C Ritter, A Pesenti, M Quintel, L M Vilander, M A Kaunisto, S T Vaara, V Pettilä, J L G Haitsma Mulier, S Rozemeijer, A M E Spoelstra-de Man, P E Elbers, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, I H J Koh, M Galindo Martínez, R Jiménez Sánchez, L Martínez Gascón, M D Rodríguez Mulero, A Ortín Freire, A Ojados Muñoz, S Rebollo Acebes, Á Fernández Martínez, S Moreno Aliaga, L Herrera Para, J Murcia Payá, F Rodríguez Mulero, P Guerci, Y Ince, P Heeman, B Ergin, C Ince, Z Uz, M Massey, Y Ince, R Papatella, E Bulent, P Guerci, F Toraman, C Ince, E R Longbottom, H D Torrance, H C Owen, C J Hinds, R M Pearse, M J O'Dywer, Z Trogrlic, M van der Jagt, H Lingsma, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, T van Achterberg, J Bakker, D A M P J Gommers, E Ista, A Krajčová, P Waldauf, F Duška, A Shah, N Roy, S McKechnie, C Doree, S Fisher, S J Stanworth, J F Jensen, D Overgaard, M H Bestle, D F Christensen, I Egerod, A Pivkina, V Gusarov, I Zhivotneva, N Pasko, M Zamyatin, J F Jensen, I Egerod, M H Bestle, D F Christensen, A Alklit, R L Hansen, H Knudsen, L B Grode, D Overgaard, M Hravnak, L Chen, A Dubrawski, G Clermont, M R Pinsky, S M Parry, L D Knight, B C Connolly, C E Baldwin, Z A Puthucheary, L Denehy, N Hart, P E Morris, J Mortimore, C L Granger, H I Jensen, R Piers, B Van den Bulcke, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, B Van den Bulcke, R Piers, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, C Ryan, D Dawson, J Ball, K Noone, B Aisling, S Prudden, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, J Aron, G Lumley, D Milliken, K Dhadwal, B A McGrath, S J Lynch, B Bovento, G Sharpe, E Grainger, S Pieri-Davies, S Wallace, B McGrath, S J Lynch, B Bovento, E Grainger, S Pieri-Davies, G Sharpe, S Wallace, M Jung, J Cho, H Park, G Suh, O Kousha, J Paddle, L Gamrin Gripenberg, M Sundström Rehal, J Wernerman, O Rooyackers, H J de Grooth, W P Choo, A M Spoelstra-de Man, E L Swart, H M Oudemans-van Straaten, L Talan, G Güven, N D Altıntas, M Padar, G Uusvel, L Starkopf, J Starkopf, A Reintam Blaser, M S Kalaiselvan, A S Arunkumar, M K Renuka, R L Shivkumar, M Volbeda, D Ten Kate, M Hoekstra, J M van der Maaten, M W Nijsten, A Komaromi, O Rooyackers, J Wernerman, Å Norberg, M Smedberg, M Mori, L Pettersson, Å Norberg, O Rooyackers, J Wernerman, M Theodorakopoulou, T Christodoulopoulou, A Diamantakis, F Frantzeskaki, M Kontogiorgi, E Chrysanthopoulou, M Lygnos, C Diakaki, A Armaganidis, K Gundogan, E Dogan, R Coskun, S Muhtaroglu, M Sungur, T Ziegler, M Guven, A Kleyman, W Khaliq, D Andreas, M Singer, R Meierhans, R Schuepbach, I De Brito-Ashurst, F Zand, G Sabetian, R Nikandish, F Hagar, M Masjedi, B Maghsudi, A Vazin, M Ghorbani, E Asadpour, K C Kao, L C Chiu, C Y Hung, C H Chang, S H Li, H C Hu, S El Maraghi, M Ali, D Rageb, M Helmy, J Marin-Corral, C Vilà, J R Masclans, A Vàzquez, I Martín-Loeches, E Díaz, J C Yébenes, A Rodriguez, F Álvarez-Lerma, N Varga, A Cortina-Gutiérrez, L Dono, M Martínez-Martínez, C Maldonado, E Papiol, M Pérez-Carrasco, R Ferrer, K Nweze, B Morton, I Welters, M Houard, B Voisin, G Ledoux, S Six, E Jaillette, S Nseir, S Romdhani, R Bouneb, D Loghmari, N Ben Aicha, J Ayachi, K Meddeb, I Chouchène, A Khedher, M Boussarsar, K S Chan, W L Yu, J Marin-Corral, C Vilà, J R Masclans, J Nolla, L Vidaur, J Bonastre, B Suberbiola, J E Guerrero, A Rodriguez, N Ramon Coll, G Jiménez Jiménez, S Carvalho Brugger, J Codina Calero, B Balsera Garrido, M García, M Palomar Martínez, M Vallverdú Vidal, M C de la Torre, E Vendrell, E Palomera, E Güell, J C Yébenes, M Serra-Prat, J F Bermejo-Martín, J Almirall, E Tomas, A Escoval, F Froe, M H Vitoria Pereira, N Velez, E Viegas, E Filipe, C Groves, M Reay, L C Chiu, H C Hu, C Y Hung, C H Chang, S H Li, K C Kao, A Ballin, F Facchin, G Sartori, F Zarantonello, E Campello, C M Radu, S Rossi, C Ori, P Simioni, N Umei, I Shingo, A C Santos, C Candeias, I Moniz, R Marçal, Z Costa E Silva, J M Ribeiro, J F Georger, J P Ponthus, M Tchir, V Amilien, M Ayoub, E Barsam, G Martucci, G Panarello, F Tuzzolino, G Capitanio, V Ferrazza, T Carollo, L Giovanni, A Arcadipane, M López Sánchez, M A González-Gay, F J Llorca Díaz, M I Rubio López, E Zogheib, L Villeret, J Nader, M Bernasinski, P Besserve, T Caus, H Dupont, P Morimont, S Habran, R Hubert, T Desaive, F Blaffart, N Janssen, J Guiot, A Pironet, P Dauby, B Lambermont, F Zarantonello, A Ballin, F Facchin, G Sartori, E Campello, T Pettenuzzo, G Citton, S Rossi, P Simioni, C Ori, C Kirakli, O Ediboglu, S Ataman, M Yarici, F Tuksavul, S Keating, A Gibson, M Gilles, M Dunn, G Price, N Young, P Remeta, P Bishop, M D Fernández Zamora, J Muñoz-Bono, E Curiel-Balsera, E Aguilar-Alonso, R Hinojosa, A Gordillo-Brenes, J A Arboleda-Sánchez, I Skorniakov, D Vikulova, C Whiteley, O Shaikh, A Jones, M Ostermann, L Forni, M Scott, J Sahatjian, W Linde-Zwirble, D Hansell, P Laoveeravat, N Srisawat, M Kongwibulwut, S Peerapornrattana, N Suwachittanont, T O Wirotwan, P Chatkaew, P Saeyub, K Latthaprecha, K Tiranathanagul, S Eiam-Ong, J A Kellum, R E Berthelsen, A Perner, A E K Jensen, J U Jensen, M H Bestle, D J Gebhard, J Price, C E Kennedy, A Akcan-Arikan, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, K Hamed, M M Khaled, R Aly Soliman, M Sherif Mokhtar, G Seller-Pérez, D Arias-Verdú, E Llopar-Valdor, I De-Diós-Chacón, G Quesada-García, M E Herrera-Gutierrez, R Hafes, G Carroll, P Doherty, C Wright, I G Guerra Vera, M Ralston, M L Gemmell, A MacKay, E Black, C Wright, R I Docking, R Appleton, M R Ralston, L Gemmell, R Appleton, C Wright, R I Docking, E Black, A Mackay, S Rozemeijer, J L G Haitsma Mulier, J G Röttgering, P W G Elbers, A M E Spoelstra-de Man, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, N Mejeni, J Nsiala, A Kilembe, P Akilimali, G Thomas, I Egerod, A E Andersson, A M Fagerdahl, V Knudsen, K Meddeb, A Ben Cheikh, Y Hamdaoui, J Ayachi, A Guiga, N Fraj, S Romdhani, N Sma, R Bouneb, I Chouchene, A Khedher, N Bouafia, M Boussarsar, A Amirian, B Ziaian, M Masjedi, C Fleischmann, D O Thomas-Rueddel, A Schettler, D Schwarzkopf, A Stacke, K Reinhart, E Filipe, A Escoval, A Martins, P Sousa, N Velez, E Viegas, E Tomas, G Snell, R Matsa, T T S Paary, M S Kalaiselvan, A M Cavalheiro, L L Rocha, C S Vallone, A Tonilo, M D S Lobato, D T Malheiro, G Sussumo, N M Lucino, F Zand, V D Rosenthal, M Masjedi, G Sabetian, B Maghsudi, M Ghorbani, A Sanaei Dashti, A Yousefipour, J R Goodall, M Williamson, E Tant, N Thomas, C Balci, C Gonen, E Haftacı, H Gurarda, E Karaca, B Paldusová, I Zýková, D Šímová, S Houston, L D'Antona, J Lloyd, V Garnelo-Rey, M Sosic, V Sotosek-Tokmazic, J Kuharic, I Antoncic, S Dunatov, A Sustic, C T Chong, M Sim, T Lyovarin, F M Acosta Díaz, S Narbona Galdó, M Muñoz Garach, O Moreno Romero, A M Pérez Bailón, A Carranza Pinel, M Colmenero, A Gritsan, A Gazenkampf, E Korchagin, N Dovbish, R M Lee, M P P Lim, C T Chong, B C L Lim, J J See, R Assis, F Filipe, N Lopes, L Pessoa, T Pereira, N Catorze, M S Aydogan, C 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Dan, N Wen Long, W Yu, Z Yan, X Cheng, T Kobayashi, Y Onodera, R Akimoto, A Sugiura, H Suzuki, M Iwabuchi, M Nakane, K Kawamae, P Carmona Sanchez, M D Bautista Rodriguez, M Rodriguez Delgado, V Martínez de Pinillos Sánchez, A Mula Gómez, J M Serrano Simón, P Beuret, C Fortes, M Lauer, M Reboul, J C Chakarian, X Fabre, B Philippon-Jouve, S Devillez, M Clerc, N Rittayamai, M Sklar, M Dres, M Rauseo, C Campbell, B West, D E Tullis, L Brochard, Y Onodera, R Akimoto, H Suzuki, M Okada, M Nakane, K Kawamae, N Ahmad, M Wood, A Glossop, J Higuera Lucas, A Blandino Ortiz, D Cabestrero Alonso, R De Pablo Sánchez, L Rey González, R Costa, G Spinazzola, A Pizza, G Ferrone, M Rossi, M Antonelli, G Conti, H Ribeiro, J Alves, M Sousa, P Reis, C S Socolovsky, R P Cauley, J E Frankel, A L Beam, K O Olaniran, F K Gibbons, K B Christopher, J Pennington, P Zolfaghari, H S King, H H Y Kong, H P Shum, W W Yan, C Kaymak, N Okumus, A Sari, B Erdogdu, S Aksun, H Basar, A Ozcan, N Ozcan, D Oztuna, J A Malmgren, S Lundin, K Torén, M Eckerström, A Wallin, A C Waldenström, F C Riccio, D Pogson, A C P Antonio, A F Leivas, F Kenji, E James, P Morgan, G Carroll, L Gemmell, A MacKay, C Wright, J Ballantyne, S Jonnada, C S Gerrard, N Jones, J D Salciccioli, D C Marshall, M Komorowski, A Hartley, M C Sykes, R Goodson, J Shalhoub, J R Fernández Villanueva, R Fernández Garda, A M López Lago, E Rodríguez Ruiz, R Hernández Vaquero, C Galbán Rodríguez, E Varo Pérez, C Hilasque, I Oliva, G Sirgo, M C Martin, M Olona, M C Gilavert, M Bodí, C Ebm, G Aggarwal, S Huddart, N Quiney, M Cecconi, S M Fernandes, J Santos Silva, J Gouveia, D Silva, R Marques, H Bento, A Alvarez, Z Costa Silva, D Díaz Diaz, M Villanova Martínez, E Palencia Herrejon, A Martinez de la Gandara, G Gonzalo, M A Lopez, P Ruíz de Gopegui Miguelena, C I Bernal Matilla, P Sánchez Chueca, M D C Rodríguez Longares, R Ramos Abril, A L Ruíz Aguilar, R Garrido López de Murillas, R Fernández Fernández, P Morales Laborías, M A Díaz Castellanos, M E Morales Laborías, J Cho, J Kim, J Park, S Woo, T West, E Powell, A Rimmer, C Orford, N Jones, J Williams, C I Bernal Matilla, P Ruiz de Gopegui Miguelena, P Sánchez Chueca, R Ramos Abril, M D C Rodríguez Longares, A L Ruíz Aguilar, R Garrido López de Murillas, R S Bourne, R Shulman, M Tomlin, G H Mills, M Borthwick, W Berry, D García Huertas, F Manzano, F Villagrán-Ramírez, A Ruiz-Perea, C Rodríguez-Mejías, F Santiago-Ruiz, M Colmenero-Ruiz, C König, B Matt, A Kortgen, C S Hartog, A Wong, C Balan, G Barker, N Srisawat, S Peerapornratana, P Laoveeravat, S Tachaboon, S Eiam-Ong, J Paratz, G Kayambu, R Boots, M F Aguilar Arzapalo, R Vlasenko, E Gromova, S Loginov, M Kiselevskiy, Y Dolgikova, K B Tang, C M Chau, K N Lam, E Gil, G Y Suh, C M Park, J Park, C R Chung, C T Lee, A Chao, P Y Shih, Y F Chang, C H Lai, Y C Hsu, Y C Yeh, Y J Cheng, V Colella, N Zarrillo, M D'Amico, F Forfori, B Pezza, T Laddomada, V Beltramelli, M L Pizzaballa, A Doronzio, B Balicco, D Kiers, W van der Heijden, J Gerretsen, Q de Mast, S El Messaoudi, G Rongen, M Gomes, M Kox, P Pickkers, N P Riksen, Y Kashiwagi, M Okada, K Hayashi, Y Inagaki, S Fujita, M N Nakamae, Y R Kang, R B Souza, A M A Liberatore, I H J Koh, A Blet, M Sadoune, J Lemarié, N Bihry, R Bern, E Polidano, R Merval, J M Launay, B Lévy, J L Samuel, A Mebazaa, J Hartmann, S Harm, V Weber
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27683974/cross-resistance-and-synergy-with-bendamustine-in-chronic-lymphocytic-leukemia
#16
Sara E F Kost, Eric D J Bouchard, Élise LaBossière, Xibiao Ye, Michelle L Queau, William S Liang, Versha Banerji, Spencer B Gibson, Sachin Katyal, James B Johnston
Bendamustine (BEN) has structural similarities to an alkylating agent and a nucleoside analog, and effective against tumor cells that are resistant to standard therapy. In this study we compared the activities of BEN against that of the alkylating agent, chlorambucil (CLB), and the nucleoside analogs, fludarabine (FLU) and deoxyadenosine/pentostatin (dADO/PEN), in primary chronic lymphocytic leukemia (CLL) cells in vitro. Cross-resistance was observed between BEN, CLB and FLU, with previously treated patients or those with a deletion 17p being most resistant...
September 20, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27680681/%C3%AE-3%C3%AE-1-integrin-suppresses-prostate-cancer-metastasis-via-regulation-of-the-hippo-pathway
#17
Afshin Varzavand, Will Hacker, Deqin Ma, Katherine Gibson-Corley, Maria Hawayek, Omar J Tayh, James A Brown, Michael D Henry, Christopher S Stipp
Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial cells have met limited success. An alternative strategy is to augment integrin-mediated pathways that suppress tumor progression, but how integrins can signal to restrain malignant behavior remains unclear. To address this issue, we generated an in vivo model of prostate cancer metastasis via depletion of α3β1 integrin, a correlation observed in a significant proportion of prostate cancers...
September 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27666313/phylogenetic-diversity-antimicrobial-susceptibility-and-virulence-characteristics-of-phylogroup-f-escherichia-coli-in-australia
#18
Belinda Vangchhia, Sam Abraham, Jan M Bell, Peter Collignon, Justine S Gibson, Paul R Ingram, James R Johnson, Karina Kennedy, Darren J Trott, John D Turnidge, David M Gordon
Unlike Escherichia coli strains belonging to phylogroup B2, the clinical significance of strains belonging to phylogroup F is not well understood. Here we report on a collection of phylogroup F strains recovered in Australia from faeces and extra-intestinal sites from humans, companion animals and native animals, as well as from poultry meat and water samples. The distribution of sequence types was clearly non-random with respect to isolate source. The antimicrobial resistance and virulence trait profiles also varied with the sequence type of the isolate...
November 2016: Microbiology
https://www.readbyqxmd.com/read/27632850/eccentric-loading-of-triceps-surae-modulates-stretch-shortening-cycle-behaviour-a-possible-therapeutic-mechanism
#19
James R Debenham, William I Gibson, Mervyn J Travers, Amity C Campbell, Garry T Allison
CONTEXT: Eccentric exercises are increasingly being used to treat lower limb musculoskeletal conditions such as Achilles tendinopathy. Despite widespread clinical application and documented efficacy, mechanisms underpinning clinical benefit remain unclear. Positive adaptations in motor performance are one potential mechanism. OBJECTIVE: To investigate how an eccentric loading intervention influences measures of stretch-shortening cycle (SSC) behaviour during a hopping task...
August 24, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27630214/regulation-of-fcr%C3%AE-function-by-site-specific-serine-phosphorylation
#20
Spandan Shah, Andrew W Gibson, Chuanyi Ji, Eric Darrington, James Mobley, Kyoko Kojima, Jeffrey C Edberg, Robert P Kimberly
The common FcRγ, an immunoreceptor tyrosine-based activation motif (ITAM)- containing adaptor protein, associates with multiple leukocyte receptor complexes and mediates signal transduction through the ITAM in the cytoplasmic domain. The presence of multiple serine and threonine residues within this motif suggests the potential for serine/threonine phosphorylation in modulating signaling events. Single-site mutational analysis of these residues in RBL-2H3 cells indicates that each may contribute to net FcRγ-mediated signaling, and mass spectrometry of WT human FcRγ from receptor-stimulated cells shows consistent preferential phosphorylation of the serine residue at position 51...
September 14, 2016: Journal of Leukocyte Biology
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