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https://www.readbyqxmd.com/read/28532134/assessing-the-efficacy-of-second-line-antiretroviral-treatment-for-hiv-patients-failing-first-line-antiretroviral-therapy-in-iran-a-cohort-study
#1
Mehrnaz Rasooli-Nejad, Maryam Khazaee-Pool, Ladan Abbasian, Zahra Bayat Jozani, Sara Ahsani-Nasab, Banafsheh Moradmand Badie, Afsaneh Pargar, Gholamreza Esmaeeli Djavid
There are limited documents about HIV patients switched to second-line antiretroviral therapy (ART) in resource-limited countries. We aimed to assess the efficacy of second-line ART for HIV patients following first-line ART failure. This was a cohort study of HIV/AIDS patients with first-line ART treatment failure switched to second-line ART between January 2004 and March 2014, who followed for at least 12 months after switching. Fifty of studied patients (85%) were treated with regimens containing lopinavir/ritonavir (Kaletra) and nine of them (15%) treated with other regimes...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532125/colorimetric-humidity-sensors-based-on-electrospun-polyamide-cocl2-nanofibrous-membranes
#2
Ming-Hao You, Xu Yan, Jun Zhang, Xiao-Xiong Wang, Xiao-Xiao He, Miao Yu, Xin Ning, Yun-Ze Long
Humidity indicators based on composite polyamide 66/cobalt chloride (PA66/CoCl2) nanofibrous membranes (NFMs) were successfully fabricated by electrospinning. A series of NFMs with various weight percentage of CoCl2 to PA66 were prepared, and their humidity sensitivity based on color changing and quartz crystal microbalance (QCM) were studied. Due to the color change property of cobalt chloride, the as-spun composite NFMs show obviously macroscopic color change from blue to pink as relative humidity (RH) increasing from 12...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532112/preparations-and-doxorubicin-controlled-release-of-amino-acid-based-redox-ph-dual-responsive-nanomicelles
#3
Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni
Terpolymers of poly (Lysine-co-N, N-Bis (acryloyl) cystamine-co-β-Phenethylamine) (PLBP) were synthesized in one-pot by Michael addition terpolymerization. The terpolymers self-assembled into nano-sized spherical micelles (84-123nm) with narrow distributions. The surface charge of the nanomicelles (NMs) was depended on solution's pH and showed negative values under physiological conditions (pH7.4), which was beneficial for long circulation without non-specific protein adsorption. Doxorubicin (DOX) was effectively loaded into the NMs for controlled release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532108/assessing-stiffness-of-nanofibres-in-bacterial-cellulose-hydrogels-numerical-experimental-framework
#4
Xing Gao, Emrah Sozumert, Zhijun Shi, Guang Yang, Vadim V Silberschmidt
This work presents a numerical-experimental framework for assessment of stiffness of nanofibres in a fibrous hydrogel - bacterial cellulose (BC) hydrogel - based on a combination of in-aqua mechanical testing, microstructural analysis and finite-element (FE) modelling. Fibrous hydrogels attracted growing interest as potential replacements to some tissues. To assess their applicability, a comprehensive understanding of their mechanical response under relevant conditions is desirable; a lack of such knowledge is mainly due to changes at microscale caused by deformation that are hard to evaluate in-situ because of the dimensions of nanofibres and aqueous environment...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532082/ultrasonic-nanotherapy-of-breast-cancer-using-novel-ultrasound-responsive-alginate-shelled-perfluorohexane-nanodroplets-in-vitro-and-in-vivo-evaluation
#5
Fatemeh Baghbani, Mahdieh Chegeni, Fathollah Moztarzadeh, Jamshid Aghazadeh Mohandesi, Manijhe Mokhtari-Dizaji
Development of a new class of multifunctional ultrasound-responsive smart nanocarriers that combine therapeutic properties with diagnostic imaging has gained great attention in recent years. Here, we describe the results of ultrasonic nanotherapy of breast cancer using novel alginate-stabilized perfluorohexane nanodroplets. Doxorubicin (Dox)-loaded multifunctional nanodroplets (Dox-NDs) were synthesized via nanoemulsion process and evaluated in vitro and in vivo with focus on cytotoxicity, hemolytic activity, biodistribution, biosafety, and antitumor activity...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532070/ribose-mediated-crosslinking-of-collagen-hydroxyapatite-hybrid-scaffolds-for-bone-tissue-regeneration-using-biomimetic-strategies
#6
Gopal Shankar Krishnakumar, Natalia Gostynska, Elisabetta Campodoni, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Anna Tampieri, Elizaveta Kon, Maurilio Marcacci, Simone Sprio, Monica Sandri
This study explores for the first time the application of ribose as a highly biocompatible agent for the crosslinking of hybrid mineralized constructs, obtained by bio-inspired mineralization of self-assembling Type I collagen matrix with magnesium-doped-hydroxyapatite nanophase, towards a biomimetic mineralized 3D scaffolds (MgHA/Coll) with excellent compositional and structural mimicry of bone tissue. To this aim, two different crosslinking mechanisms in terms of pre-ribose glycation (before freeze drying) and post-ribose glycation (after freeze drying) were investigated...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532059/selective-determination-of-ag-using-salecan-derived-nitrogen-doped-carbon-dots-as-a-fluorescent-probe
#7
Junjian Li, Gancheng Zuo, Xiaoliang Qi, Wei Wei, Xiaohao Pan, Ting Su, Jianfa Zhang, Wei Dong
We report that nitrogen doped carbon dots (N-CDs) represent a viable fluorescent probe for the determination of Ag(+). The N-CDs can be fairly easily prepared by a hydrothermal treatment method using Salecan and dicyandiamide as the precursors, display excitation/emission maxima of 350/438nm. The N-CDs have an average diameter of about 3.8nm. The N-CDs exhibited blue fluorescence (quantum yield of 13.2%) and could response to Ag(+) selectively and sensitively. Other ions nearly had no interference. The probe has excellent selectivity, high sensitivity, and a linear response range that extends from 0 to 40μM...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532042/ph-responsive-poly-aspartic-acid-hydrogel-coated-magnetite-nanoparticles-for-biomedical-applications
#8
Jaime Vega-Chacón, María Isabel Amaya Arbeláez, Janaina Habib Jorge, Rodrigo Fernando C Marques, Miguel Jafelicci
A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532038/dynamic-covalent-linked-triblock-copolymer-micelles-for-glutathione-mediated-intracellular-drug-delivery
#9
Xueli Wang, Changyu He, Qinglai Yang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong, Yu-Mei Shen
Redox-responsive linkages dispersed in the backbones of the synthetic polymers, while young in the current spectrum of the biomedical application, are rapidly extending into their niche. In the present work, triblock copolymer PEG-PLA-PEG synthesized and characterized by (1)H -NMR and SEC can self-assemble into redox-responsive micelles in aqueous media with nanosized 33nm and 47nm. And the copolymers PEG2000-PLA3000-PEG2000 and PEG2000-PLA5000-PEG2000 present lower CMC with 0.034 and 0.022mg/mL, and higher DLC of 4...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532033/synthesis-of-nano-sized-timolol-imprinted-polymer-via-ultrasonication-assisted-suspension-polymerization-in-silicon-oil-and-its-use-for-the-fabrication-of-timolol-voltammetric-sensor
#10
Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei, Maedeh Akhoundian
A novel timolol voltammetric sensor based on the nano-sized molecularly imprinted polymer (nano-MIP)-modified carbon paste electrode was introduced. Timolol-imprinted polymers (MIP) were synthesized by the ultrasonic assisted suspension polymerization in silicon oil. The MIP nanoparticles were then embedded in a carbon paste (CP) electrode in order to prepare the nano-MIP-CP electrode. Timolol was extracted in the electrode for a definite time and then it was analyzed by square wave voltammetry, found to be an effective determination method...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532032/agar-gelatin-bilayer-gel-matrix-fabricated-by-simple-thermo-responsive-sol-gel-transition-method
#11
Yifeng Wang, Meng Dong, Mengmeng Guo, Xia Wang, Jing Zhou, Jian Lei, Chuanhang Guo, Chaoran Qin
We present a simple and environmentally-friendly method to generate an agar/gelatin bilayer gel matrix for further biomedical applications. In this method, the thermally responsive sol-gel transitions of agar and gelatin combined with the different transition temperatures are exquisitely employed to fabricate the agar/gelatin bilayer gel matrix and achieve separate loading for various materials (e.g., drugs, fluorescent materials, and nanoparticles). Importantly, the resulting bilayer gel matrix provides two different biopolymer environments (a polysaccharide environment vs a protein environment) with a well-defined border, which allows the loaded materials in different layers to retain their original properties (e...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532026/high-performance-hydrogen-sensor-based-on-mn-implanted-zno-nanowires-array-fabricated-on-ito-substrate
#12
A Renitta, K Vijayalakshmi
In the present research, we propose a novel approach for the detection of hydrogen gas using Mn implanted ZnO nanowires fabricated onto ITO coated glass substrate by chemical spray pyrolysis deposition. The effect of Mn concentration on the structural, optical and morphological properties of ZnO films were investigated. X-ray diffraction studies showed that the Mn implanted ZnO films were grown as a polycrystalline hexagonal wurtzite phase without any impurities. The (101) peak position of ZnO-Mn films was shifted towards a lower angle with increasing Mn concentration...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532024/the-effect-of-pore-size-and-porosity-on-mechanical-properties-and-biological-response-of-porous-titanium-scaffolds
#13
C Torres-Sanchez, F R A Al Mushref, M Norrito, K Yendall, Y Liu, P P Conway
The effect of pore size and porosity on elastic modulus, strength, cell attachment and cell proliferation was studied for Ti porous scaffolds manufactured via powder metallurgy and sintering. Porous scaffolds were prepared in two ranges of porosities so that their mechanical properties could mimic those of cortical and trabecular bone respectively. Space-holder engineered pore size distributions were carefully determined to study the impact that small changes in pore size may have on mechanical and biological behaviour...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532020/ph-responsive-drug-release-and-real-time-fluorescence-detection-of-porous-silica-nanoparticles
#14
Xu Zhang, Yamin Wang, Yanbao Zhao, Lei Sun
In this work, pH-sensitive "dual-switch" porous silica (pSiO2) nanoparticles (NPs) were constructed for drug delivery. Poly(acrylic acid) (PAA) was grafting onto the internal and external surfaces of amino groups functionalized porous silica (pSiO2-NH2) NPs by the amidation between the amino groups and the carboxyl groups of PAA for pH triggered drug release. The resultant pSiO2/PAA NPs have an average diameter of 50-60nm and high specific surface area (914m(2)·g(-1)). To improve the loading capacity, ZnO quantum dots (QDs) were used to block the partial pores of pSiO2/PAA and the loading capacity reached to 28% for methotrexate (MTX) model drug...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532016/electrochemical-preparation-of-two-nanostructured-poly-sulfosalicylic-acid-films-with-different-morphologies-and-properties-for-selective-sensing-of-dopamine-comparative-study
#15
Juan Zhang, Jun-Ping Zhou, Xiao-Hui Dai, Guang-Zhou Liu, Shu-Yong Zhang
Two nanostructured poly(sulfosalicylic acid) (PSA) films were synthesized from room temperature ionic liquid (RTIL) or aqueous solution on a glassy carbon electrode (GCE) via potentiodynamic electropolymerization. The morphology and properties of the PSA films were characterized with scanning electron microscopy (SEM), scanning probe microscopy (SPM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). It was found that solvent had a major influence on the morphology and electrochemical properties of the resultant PSA films...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532010/design-of-experiments-for-microencapsulation-applications-a-review
#16
REVIEW
Filipa Paulo, Lúcia Santos
Microencapsulation techniques have been intensively explored by many research sectors such as pharmaceutical and food industries. Microencapsulation allows to protect the active ingredient from the external environment, mask undesired flavours, a possible controlled release of compounds among others. The purpose of this review is to provide a background of design of experiments in microencapsulation research context. Optimization processes are required for an accurate research in these fields and therefore, the right implementation of micro-sized techniques at industrial scale...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532002/electrochemical-sensor-for-detection-of-hydrogen-peroxide-modified-with-prussian-blue-electrodeposition-on-nitrogen-phosphorus-and-sulfur-co-doped-porous-carbons-chitosan
#17
Xiurong Zhai, Yonghong Li, Jisen Li, Chengyang Yue, Xiaowu Lei
Nitrogen, phosphorus and sulfur co-doped porous carbons (N, P, S@PC) were well dispersed in the chitosan (CS) acid solution, in particular via covalently interaction, which could avoid the aggregation of N, P, S@PC in most solvents. Moreover, CS could also avoid N, P, S@PC leakage from the modified electrode. A novel electrochemical sensor was then developed through prussian blue (PB) was electrodeposited on the glass carbon (GC) electrode modified with N, P, S@PC-CS composite. Results with scanning electron microscopy image, illustrate that PB/N, P, S@PC-CS composite distributes very uniformly on the substrate surface, which is hoped to be very attractive for determination of hydrogen peroxide (H2O2)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531999/zro2-toughened-al2o3-based-near-net-shaped-femoral-head-unique-fabrication-approach-3d-microstructure-burst-strength-and-muscle-cell-response
#18
Debasish Sarkar, Sourav Mandal, B S Reddy, Nitu Bhaskar, D C Sundaresh, Bikramjit Basu
The development of reliable biomedical devices demands the use of an integrated manufacturing protocol with comprehensive understanding of prototype characterization in terms of 3D microstructural analysis along with biocompatibility. While addressing these issues for ZrO2 (3mol% Y2O3 stabilized)-toughened Al2O3-based femoral head prototypes, the present work reports a unique fabrication protocol involving a sequence of uniaxial compaction followed by pre-sintering, machining, final sintering and polishing to ensure dimensional tolerance with respect to the design of patient-specific femoral head...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531994/a-facile-one-step-method-for-preparation-of-fe3o4-cs-inh-nanoparticles-as-a-targeted-drug-delivery-for-tuberculosis
#19
Chili Zhao, Xun Liu, Xia Zhang, Hong Yan, Zhilei Qian, Xinghui Li, Zhenye Ma, Qiaorong Han, Chonghua Pei
In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531988/optimization-of-toxic-biological-compound-adsorption-from-aqueous-solution-onto-silicon-and-silicon-carbide-nanoparticles-through-response-surface-methodology
#20
Vinod Kumar Gupta, Ali Fakhri, Sahar Rashidi, Ahmed A Ibrahim, Mohammad Asif, Shilpi Agarwal
The subject of this paper is removal of Aflatoxin B1 as toxic biological compound adsorption onto Silicon (Si) and Silicon carbide (SiC) nanoparticles in aqueous matrices using Response surface methodology. The surface frame of Si and SiC nanoparticles were comminuted by XRD, TEM, SEM, and BET. Experiments were steered well-found by Box-Behnken plan (BBD). Experiments of batch method were performed to prognosticate the reaction equilibrium of Aflatoxin B1 removal. The response surface methodological approach was used...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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