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https://www.readbyqxmd.com/read/29454302/aerobic-exercise-inhibits-obesity-induced-respiratory-phenotype
#1
Jefferson Comin Jonco Aquino-Junior, BreAnne MacKenzie, Ana Roberta Almeida-Oliveira, Ana Carolina Martins, Manoel Carneiro Oliveira-Junior, Auriléa Aparecida Britto, Fernanda Magalhaes Arantes-Costa, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Ligeiro de Oliveira, Dioze Guadagnini, Luiz Osorio Leiria, Djalma Rabelo Ricardo, Mario Jose Abdalla Saad, Rodolfo Paula Vieira
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15)...
February 14, 2018: Cytokine
https://www.readbyqxmd.com/read/29454300/gold-copper-bimetallic-nanoparticles-supported-on-nano-p-zeolite-modified-carbon-paste-electrode-as-an-efficient-electrocatalyst-and-sensitive-sensor-for-determination-of-hydrazine
#2
Fatemeh Amiripour, Seyed Naser Azizi, Shahram Ghasemi
In this report, a facile, efficient and low cost electrochemical sensor based on bimetallic Au-Cu nanoparticles supported on P nanozeolite modified carbon paste electrode (Au-Cu/NPZ/CPE) was constructed and its efficiency for determination of hydrazine in trace level was studied. For this purpose, agro waste material, stem sweep ash (SSA) was employed as the starting material (silica source) for the synthesis of nano P zeolite (NPZ). After characterization of the synthesized NPZ by analytical instruments (scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy), construction of Au-Cu/NPZ/CPE was performed by three steps procedure involving preparation of nano P zeolite modified carbon paste electrode (NPZ/CPE), introducing Cu +2 ions into nano zeolite structure by ion exchange and electrochemical reduction of Cu +2 ions upon applying constant potential...
February 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29454293/health-professions-faculty-beliefs-confidence-use-and-perceptions-of-organizational-culture-and-readiness-for-ebp-a-cross-sectional-descriptive-survey
#3
Kerry A Milner, Holly B Bradley, Tammy Lampley
BACKGROUND: Evidence-based practice (EBP) is an essential skill and ethical obligation for all practicing health professions clinicians because of its strong association with improved health outcomes. Emerging evidence suggests that faculty who prepare these clinicians lack proficiency to teach EBP. OBJECTIVES: The purpose of this study was to describe; 1) health profession faculty beliefs about and confidence in their ability to teach and implement EBP, 2) use of EBP for education, 3) organizational culture and readiness for EBP; and to determine whether relationships exist among these variables...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454292/the-nursification-of-a-bioscience-unit-and-its-impact-on-student-satisfaction-and-learning-in-an-undergraduate-nursing-degree
#4
Sheila Mortimer-Jones, Catherine Fetherston
Undergraduate nursing students traditionally find bioscience difficult, which can be compounded by an inability to relate bioscience theory to nursing practice. Subsequently, many registered nurses feel they lack knowledge in this area. Several studies have identified this problem and focused on the importance of linking bioscience theory in undergraduate nursing curricula to clinical practice. The aim of this study was to assess whether nursification (the active association of a subject with nursing theory and practice) of the bioscience content of a first year, first semester unit impacts on the students' learning experience...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454282/contaminants-of-emerging-concern-presence-and-adverse-effects-in-fish-a-case-study-in-the-laurentian-great-lakes
#5
Zachary G Jorgenson, Linnea M Thomas, Sarah M Elliott, Jenna E Cavallin, Eric C Randolph, Steven J Choy, David A Alvarez, Jo A Banda, Daniel J Gefell, Kathy E Lee, Edward T Furlong, Heiko L Schoenfuss
The Laurentian Great Lakes are a valuable natural resource that is affected by contaminants of emerging concern (CECs), including sex steroid hormones, personal care products, pharmaceuticals, industrial chemicals, and new generation pesticides. However, little is known about the fate and biological effects of CECs in tributaries to the Great Lakes. In the current study, 16 sites on three rivers in the Great Lakes basin (Fox, Cuyahoga, and Raquette Rivers) were assessed for CEC presence using polar organic chemical integrative samplers (POCIS) and grab water samplers...
February 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29454274/a-multifaceted-coating-on-titanium-dictates-osteoimmunomodulation-and-osteo-angio-genesis-towards-ameliorative-osseointegration
#6
Long Bai, Zhibin Du, Jingjing Du, Wei Yao, Jiaming Zhang, Zeming Weng, Si Liu, Ya Zhao, Yanlian Liu, Xiangyu Zhang, Xiaobo Huang, Xiaohong Yao, Ross Crawford, Ruiqiang Hang, Di Huang, Bin Tang, Yin Xiao
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO 2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454273/mechanosensitive-adhesion-complexes-in-epithelial-architecture-and-cancer-onset
#7
REVIEW
Minerva Bosch-Fortea, Fernando Martín-Belmonte
Mechanical signals from the extracellular space are paramount to coordinate tissue morphogenesis and homeostasis. Although there is a wide variety of cellular mechanisms involved in transducing extracellular forces, recent literature emphasizes the central role of two main adhesion complexes in epithelial mechanosensitive processes: focal adhesions and adherens junctions. These biomechanical sensors can decode physical signals such as matrix stiffness or intercellular tension into a wide range of coordinated cellular responses, which can impact cell differentiation, migration, and proliferation...
February 14, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29454270/cadmium-induced-stress-response-of-phanerochaete-chrysosporium-during-the-biodegradation-of-2-2-4-4-tetrabromodiphenyl-ether-bde-47
#8
Mi Feng, Hua Yin, Yajuan Cao, Hui Peng, Guining Lu, Zehua Liu, Zhi Dang
Cd-induced stress response of Phanerochaete chrysosporium during the biodegradation of BDE-47 was investigated in this study, with the goal of elucidating the tolerance behavior and the detoxification mechanisms of P. chrysosporium to resist the Cd stress in the course of BDE-47 biodegradation, which has implications for expanding the application of P. chrysosporium in the bioremediation of Cd and BDE-47 combined pollution. The results suggested that single BDE-47 exposure did not induce obvious oxidative stress in P...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454262/the-influence-of-evaluation-recommendations-on-instrumental-and-conceptual-uses-a-preliminary-analysis
#9
Isabelle Bourgeois, Jane Whynot
Evaluation recommendations are sometimes included in evaluation reports to highlight specific actions to be taken to improve a program or to make other changes to its operational context. This preliminary study sought to examine evaluation recommendations drawn from 25 evaluation reports published by Canadian federal government departments and agencies, in order to examine the evaluation issues covered and the focus of the recommendations. Our results show that in keeping with policy requirements, the evaluation recommendations focused on program relevance, effectiveness and efficiency and economy...
February 10, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29454249/dft-study-of-electron-absorption-and-emission-spectra-of-pyramidal-lnpc-oac-complexes-of-some-lanthanide-ions-in-the-solid-state
#10
J Hanuza, P Godlewska, R Lisiecki, W Ryba-Romanowski, P Kadłubański, J Lorenc, A Łukowiak, L Macalik, Yu Gerasymchuk, J Legendziewicz
The electron absorption and emission spectra were measured for the pyramidal LnPc(OAc) complexes in the solid state and co-doped in silica glass, where Ln=Er, Eu and Ho. The theoretical electron spectra were determined from the quantum chemical DFT calculation using four approximations CAM-B3LYP/LANL2DZ, CAM-B3LYP/CC-PVDZ, B3LYP/LANL2DZ and B3LYP/CC-PVDZ. It was shown that the best agreement between the calculated and experimental structural parameters and spectroscopic data was reached for the CAM-B3LYP/LANL2DZ model...
January 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454247/tolerance-and-growth-kinetics-of-bacteria-isolated-from-gold-and-gemstone-mining-sites-in-response-to-heavy-metal-concentrations
#11
Oluwatosin Gbemisola Oladipo, Obinna Tobechukwu Ezeokoli, Mark Steve Maboeta, Jacobus Johannes Bezuidenhout, Louwrens R Tiedt, Anine Jordaan, Cornelius Carlos Bezuidenhout
Response and growth kinetics of microbes in contaminated medium are useful indices for the screening and selection of tolerant species for eco-friendly bio-augmentative remediation of polluted environments. In this study, the heavy metal (HM) tolerance, bioaccumulation and growth kinetics of seven bacterial strains isolated from mining sites to 10 HMs (Cd, Hg, Ni, Al, Cr, Pb, Cu, Fe, Mn and Zn) at varied concentrations (25-600 mgL -1 ) were investigated. The isolates were phylogenetically (16S rRNA gene) related to Lysinibacillus macroides, Achromobacter spanius, Bacillus kochii, B...
February 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#12
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454233/combined-effect-of-water-inundation-and-heavy-metals-on-the-photosynthesis-and-physiology-of-spartina-alterniflora
#13
Xiangli Sun, Yan Xu, Qiqiong Zhang, Xiuzhen Li, Zhongzheng Yan
The frequency and duration of tidal flooding significantly influence the bioavailability of heavy metals (HMs) in sediment and hence exert toxicological effects on coastal wetland plants. In this study, the combined effects of different water inundation times (3, 6, 9, and 12 h) and HMs (Cu, Zn, Pb, and Cr) on the photosynthesis and physiology of Spartina alterniflora were investigated under greenhouse conditions. Results showed that S. alterniflora was somehow tolerant to the combined HMs treatments, and only the highest level of HM treatment decreased leaf chlorophyll content...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454225/low-power-lasers-on-genomic-stability
#14
Larissa Alexsandra da Silva Neto Trajano, Luiz Philippe da Silva Sergio, Ana Carolina Stumbo, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Exposure of cells to genotoxic agents causes modifications in DNA, resulting to alterations in the genome. To reduce genomic instability, cells have DNA damage responses in which DNA repair proteins remove these lesions. Excessive free radicals cause DNA damages, repaired by base excision repair and nucleotide excision repair pathways. When non-oxidative lesions occur, genomic stability is maintained through checkpoints in which the cell cycle stops and DNA repair occurs. Telomere shortening is related to the development of various diseases, such as cancer...
February 10, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29454216/non-linear-effects-of-mean-temperature-and-relative-humidity-on-dengue-incidence-in-guangzhou-china
#15
Xiaocheng Wu, Lingling Lang, Wenjun Ma, Tie Song, Min Kang, Jianfeng He, Yonghui Zhang, Liang Lu, Hualiang Lin, Li Ling
BACKGROUND: Dengue fever is an important infectious disease in Guangzhou, China; previous studies on the effects of weather factors on the incidence of dengue fever did not consider the linearity of the associations. METHODS: This study evaluated the effects of daily mean temperature, relative humidity and rainfall on the incidence of dengue fever. A generalized additive model with splines smoothing function was performed to examine the effects of daily mean, minimum and maximum temperatures, relative humidity and rainfall on incidence of dengue fever during 2006-2014...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454215/effect-based-trigger-values-for-in-vitro-and-in-vivo-bioassays-performed-on-surface-water-extracts-supporting-the-environmental-quality-standards-eqs-of-the-european-water-framework-directive
#16
Beate I Escher, Selim Aїt-Aїssa, Peter A Behnisch, Werner Brack, François Brion, Abraham Brouwer, Sebastian Buchinger, Sarah E Crawford, David Du Pasquier, Timo Hamers, Karina Hettwer, Klára Hilscherová, Henner Hollert, Robert Kase, Cornelia Kienle, Andrew J Tindall, Jochen Tuerk, Ron van der Oost, Etienne Vermeirssen, Peta A Neale
Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only benchmarked against each other but not against a consented measure of chemical water quality. The EU environmental quality standards (EQS) differentiate between acceptable and unacceptable surface water concentrations for individual chemicals but cannot capture the thousands of chemicals in water and their biological action as mixtures...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454200/effect-of-clonal-integration-on-nitrogen-cycling-in-rhizosphere-of-rhizomatous-clonal-plant-phyllostachys-bissetii-under-heterogeneous-light
#17
Yang Li, Jing-Song Chen, Ge Xue, Yuanying Peng, Hui-Xing Song
Clonal integration plays an important role in clonal plant adapting to heterogeneous habitats. It was postulated that clonal integration could exhibit positive effects on nitrogen cycling in the rhizosphere of clonal plant subjected to heterogeneous light conditions. An in-situ experiment was conducted using clonal fragments of Phyllostachys bissetii with two successive ramets. Shading treatments were applied to offspring or mother ramets, respectively, whereas counterparts were treated to full sunlight. Rhizomes between two successive ramets were either severed or connected...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454194/diagnostic-and-treatment-services-for-patients-with-psychogenic-nonepileptic-seizures-pnes-a-survey-of-health-professionals-in-urban-china
#18
Xin Tong, Dongmei An, Markus Reuber, Qin Zhang, Dong Zhou
PURPOSE: This study is intended to provide an overview of diagnostic and treatment services for patients with psychogenic nonepileptic seizures (PNES) across China. METHODS: Using a questionnaire devised by the PNES Task Force of Neuropsychiatry Commission of the International League Against Epilepsy (ILAE), we conducted a survey among Chinese health professionals at the Sixth Advanced International Course: Clinical Epileptology. Descriptive analyses were performed...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29454178/caffeine-use-disorder-an-item-response-theory-analysis-of-proposed-dsm-5-criteria
#19
Csilla Ágoston, Róbert Urbán, Mara J Richman, Zsolt Demetrovics
INTRODUCTION: Caffeine is a common psychoactive substance with a documented addictive potential. Caffeine withdrawal has been included in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), but caffeine use disorder (CUD) is considered to be a condition for further study. The aim of the current study is (1) to test the psychometric properties of the Caffeine Use Disorder Questionnaire (CUDQ) by using a confirmatory factor analysis and an item response theory (IRT) approach, (2) to compare IRT models with varying numbers of parameters and models with or without caffeine consumption criteria, and (3) to examine if the total daily caffeine consumption and the use of different caffeinated products can predict the magnitude of CUD symptomatology...
February 9, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29454161/physiological-low-dose-oestrogen-promotes-the-development-of-experimental-autoimmune-thyroiditis-through-the-up-regulation-of-th1-th17-responses
#20
Yang Xiang, Qian Jin, Li Li, Yali Yang, Hongmei Zhang, Miao Liu, Chenling Fan, Jing Li, Zhongyan Shan, Weiping Teng
Previous studies have reported a preponderance of autoimmune thyroiditis (AIT) in females, but the detailed mechanisms have not been elucidated. In this study, we explored the effects of oestrogen on experimental AIT (EAT) and its potential mechanisms in an ovariectomised mouse model through the supplementation of high (equivalent to the level during pregnancy) or low (equivalent to the level at the oestrus stage) doses of oestradiol (E2). We found that EAT incidence, the intrathyroidal inflammatory score, serum anti-thyroglobulin IgG2b levels, splenic mRNA expression of Th1- and Th17-specific transcription factors and typical cytokines and the proportion of IL-12-producing dendritic cells were significantly increased in EAT mice treated with low-dose E2 compared with those in the control group...
February 7, 2018: Journal of Reproductive Immunology
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