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https://www.readbyqxmd.com/read/29679945/occurrence-elimination-enantiomeric-distribution-and-intra-day-variations-of-chiral-pharmaceuticals-in-major-wastewater-treatment-plants-in-beijing-china
#1
Lei Duan, Yizhe Zhang, Bin Wang, Shubo Deng, Jun Huang, Yujue Wang, Gang Yu
The occurrence, eliminations, enantiomeric distribution and intra-day variations of five chiral pharmaceuticals (three beta-blockers and two antidepressants) were investigated in eight major WWTPs in Beijing, China. The results revealed that metoprolol (MTP) and venlafaxine (VFX) were of the highest concentrations among the five determined pharmaceuticals with mean concentrations of 803 ng L-1 and 408 ng L-1 , respectively in influents, and 354 ng L-1 and 165 ng L-1 in effluents, respectively...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679940/nmr-based-metabolic-toxicity-of-low-level-hg-exposure-to-earthworms
#2
Ronggui Tang, Changfeng Ding, Fei Dang, Yibing Ma, Junsong Wang, Taolin Zhang, Xingxiang Wang
Mercury is a globally distributed toxicant to aquatic animals and mammals. However, the potential risks of environmental relevant mercury in terrestrial systems remain largely unclear. The metabolic profiles of the earthworm Eisenia fetida after exposure to soil contaminated with mercury at 0.77 ± 0.09 mg/kg for 2 weeks were investigated using a two-dimensional nuclear magnetic resonance-based (1 H-13 C NMR) metabolomics approach. The results revealed that traditional endpoints (e.g., mortality and weight loss) did not differ significantly after exposure...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679933/slip-avoidance-strategies-in-children-with-bilateral-spastic-cerebral-palsy-and-crouch-gait
#3
Ana Francisca Rozin Kleiner, Ilaria Pacifici, Claudia Condoluci, Chiarella Sforza, Manuela Galli
BACKGROUND: A slip occurs when the required friction (RCOF) to prevent slipping at the foot/floor interfaces exceeds the available friction. The RCOF is dependent upon the biomechanics features of individuals and their gait. On the other hand, the available friction depends on environmental features. Once individuals with crouch gait have their biomechanics of gait completely altered, how do they interact with a supporting surface? The aim was to quantify the RCOF in children with bilateral spastic cerebral palsy (BSCP) and crouch gait...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29679931/a-dual-spectroscopic-fluorescence-probe-based-on-carbon-dots-for-detection-of-2-4-6-trinitrophenol-fe-iii-ion-by-fluorescence-and-frequency-doubling-scattering-spectra-and-its-analytical-applications
#4
Jinxia Xu, Zhangjun Bai, Fanlin Zu, Fanyong Yan, Junfu Wei, Saihui Zhang, Yunmei Luo
A convenient, highly sensitive and reliable assay for 2,4,6‑trinitrophenol (TNP) and Fe (III) ion (Fe3+ ) in the dual spectroscopic manner is developed based on novel carbon dots (CDs). The CDs with highly blue emitting fluorescent were easily prepared via the one-step potassium hydroxide-assisted reflux method from dextrin. The as-synthesized CDs exhibited the high crystalline quality, the excellent fluorescence characteristics with a high quantum yield of ~13.1%, and the narrow size distribution with an average diameter of 6...
April 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29679917/possible-impacts-of-sea-level-rise-on-disease-transmission-and-potential-adaptation-strategies-a-review
#5
REVIEW
Ana C Dvorak, Helena M Solo-Gabriele, Andrea Galletti, Bernardo Benzecry, Hannah Malone, Vicki Boguszewski, Jason Bird
Sea levels are projected to rise in response to climate change, causing the intrusion of sea water into land. In flat coastal regions, this would generate an increase in shallow water covered areas with limited circulation. This scenario raises a concern about the consequences it could have on human health, specifically the possible impacts on disease transmission. In this review paper we identified three categories of diseases which are associated with water and whose transmission can be affected by sea level rise...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679912/effects-of-ugt2b7-scn1a-and-cyp3a4-on-the-therapeutic-response-of-sodium-valproate-treatment-in-children-with-generalized-seizures
#6
Weixing Feng, Shenghui Mei, Leting Zhu, Yazhen Yu, Weili Yang, Baoqin Gao, Xiaojuan Wu, Zhigang Zhao, Fang Fang
PURPOSE: This study aims to evaluate the associations between genetic polymorphisms and the effect of sodium valproate (VPA) therapy in children with generalized seizures. METHODS: A total of 174 children with generalized seizures on VPA therapy were enrolled. Steady-state trough plasma concentrations of VPA were analyzed. Seventy-six single nucleotide polymorphisms involved in the absorption, metabolism, transport, and target receptor of VPA were identified, and their associations with the therapeutic effect (seizure reduction) were evaluated using logistic regression adjusted by various influence factors...
April 14, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29679911/the-effects-of-valproate-and-topiramate-use-on-serum-insulin-leptin-neuropeptide-y-and-ghrelin-levels-in-epileptic-children
#7
Nafiye Polat Çiçek, Tülay Kamaşak, Mine Serin, Aysenur Okten, Ahmet Alver, Ali Cansu
PURPOSE: Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described. The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group. METHOD: 48 patients (25 VPA, 23 TPM) aged between 6 and 15...
April 11, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29679908/recent-advances-in-colony-stimulating-factor-1-receptor-c-fms-as-an-emerging-target-for-various-therapeutic-implications
#8
REVIEW
Archana Kumari, Om Silakari, Rajesh K Singh
Colony stimulating factor-1 (CSF-1) is one of the most common proinflammatory cytokine responsible for various inflammatory disorders. It has a remarkable role in the development and progression of osteoarthritis, cancer and other autoimmune disease conditions. The CSF-1 acts by binding to the receptor, called colony stimulating factor-1 receptor (CSF-1R) also known as c-FMS resulting in the cascade of signalling pathway causing cell proliferation and differentiation. Interleukin-34 (IL-34), recently identified as another ligand for CSF-IR, is a cytokine protein...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679893/identification-of-homocysteine-suppressive-mitochondrial-etc-complex-genes-and-tissue-expression-profile-novel-hypothesis-establishment
#9
Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-Feng Li, Jahaira Lopez, William Y Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) which has been implicated in matochondrial (Mt) function impairment. In this study, we characterized Hcy metabolism in mouse tissues by using LC-ESI-MS/MS analysis, established tissue expression profiles for 84 nuclear-encoded Mt electron transport chain complex (nMt-ETC-Com) genes in 20 human and 19 mouse tissues by database mining, and modeled the effect of HHcy on Mt-ETC function. Hcy levels were high in mouse kidney/lung/spleen/liver (24-14 nmol/g tissue) but low in brain/heart (~5 nmol/g)...
April 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679879/polygenic-risk-score-of-serpina6-serpina1-associates-with-diurnal-and-stress-induced-hpa-axis-activity-in-children
#10
Siddheshwar Utge, Katri Räikkönen, Eero Kajantie, Jari Lipsanen, Sture Andersson, Timo Strandberg, Rebecca M Reynolds, Johan G Eriksson, Jari Lahti
PURPOSE: Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood. Variation in genes SERPINA6 encoding for CBG, SERPINA2 and SERPINA1 (serpin family A member 6, 2, and 1) have been shown to influence morning plasma cortisol and CBG in adults. However, association of this genetic variation with diurnal and stress-induced salivary cortisol remain unknown. This study aims to investigate the effect of genetic variation in SERPINA6/2/1 loci on diurnal and stress-induced salivary cortisol in children...
April 13, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29679873/disentangling-the-mental-health-impact-of-childhood-abuse-and-neglect-a-replication-and-extension-study-in-a-brazilian-sample-of-high-risk-youth
#11
Irismar Reis de Oliveira, Ana Cristina Matos-Ragazzo, Yuning Zhang, Nina Maia Vasconcelos, Michella Lopes Velasquez, Daniela Reis, Monica Gonçalves Ribeiro, Marina Monzani da Rocha, Maria Conceição Rosario, Paul Stallard, Charlotte A M Cecil
Childhood maltreatment is a key predictor of mental health problems across the life span. Yet, how maltreatment types independently and jointly influence the risk for psychiatric problems remains unclear. The aim of the study was two-fold: first, to replicate recent findings regarding the impact of maltreatment types on youth psychiatric symptoms, based on a Brazilian sample of high-risk adolescents (n = 347; age range = 11-17 yrs), and second, to extend existing findings by examining whether this relationship is mediated by bullying victimization and/or perpetration...
April 18, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29679867/n-acetylcysteine-protects-against-microcystin-lr-induced-endoplasmic-reticulum-stress-and-germ-cell-apoptosis-in-zebrafish-testes
#12
Sujuan Zhao, Ying Liu, Fang Wang, Dexiang Xu, Ping Xie
Previous studies have shown that microcystin-LR (MCLR) is a reproductive toxicant that induces germ cell apoptosis in the testes, but the underlying mechanisms have not been well understood. In this study, we investigated that MCLR induces germ cell apoptosis is through activation of endoplasmic reticulum (ER) stress and N-acetylcysteine (NAC), an antioxidant could protect against germ cell apoptosis by inhibiting the ER stress. Healthy male zebrafish were intraperitoneally injected with NAC (500 nM), beginning at 2 h before different doses of MCLR (0, 50, 100, 200 μg/kg)...
April 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679856/b7-h6-expression-is-induced-by-lipopolysaccharide-and-facilitates-cancer-invasion-and-metastasis-in-human-gliomas
#13
Fengyuan Che, Xiaoli Xie, Long Wang, Quanping Su, Feiyu Jia, Yufu Ye, Lanlan Zang, Jing Wang, Hongyan Li, Yanchun Quan, Cuiping You, Jiawei Yin, Zhiqiang Wang, Gen Li, Yifeng Du, Lijuan Wang
Although great progress has been made in treatment regimens, gliomas are still incurable and the 5-year survival remains poor. Studies focusing on molecules that regulate tumorigenesis or tumor immunity may provide potential therapeutic strategies for patients with glioma. B7-H6 is selectively expressed in tumor cells and plays vital roles in host immune responses. In this study, we demonstrated that B7-H6 was expressed in glioma cell lines, including CRT, U251, SHG-44, SF-295, TG-905 and U373, and tumor tissues isolated from glioma patients...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679855/rutin-and-rutin-conjugated-gold-nanoparticles-ameliorate-collagen-induced-arthritis-in-rats-through-inhibition-of-nf-%C3%AE%C2%BAb-and-inos-activation
#14
Anum Gul, Bimal Kunwar, Maryam Mazhar, Shaheen Faizi, Dania Ahmed, Muhammad Raza Shah, Shabana U Simjee
Numerous studies have suggested that nuclear factor-κB (NF-κB) and inducible nitric oxide synthase (iNOS) are important mediators of inflammatory response in human and animal models of arthritis. Besides, oxidative stress markers, nitric oxide (NO) and peroxide (PO) are also major contributors in the pathogenesis of rheumatoid arthritis (RA). Over expression of these inflammatory mediators leads to the extracellular matrix degradation, and excessive cartilage and bone resorption, ultimately leading to the irreversible damage to joints...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679854/thymol-attenuates-the-worsening-of-atopic-dermatitis-induced-by-staphylococcus-aureus-membrane-vesicles
#15
Hyo Il Kwon, Na Hee Jeong, So Hyun Jun, Joo Hee Son, Shukho Kim, Hyejin Jeon, Sun Chul Kang, Sang Hyun Kim, Je Chul Lee
Staphylococcus aureus membrane vesicles (MVs) aggravate atopic dermatitis (AD) through the delivery of bacterial effector molecules to host cells and the stimulation of inflammatory responses. This study investigated the inhibitory effect of thymol, a phenolic monoterpene found in essential oils derived from plants, on the worsening of AD induced by S. aureus MVs both in vitro and in vivo. The sub-minimal inhibitory concentrations of thymol disrupted S. aureus MVs. Intact S. aureus MVs induced the expression of pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α) and chemokine (IL-8 and monocyte chemoattractant protein-1) genes in cultured keratinocytes, whereas thymol-treated S...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679842/context-matters-social-cognition-task-performance-in-psychometric-schizotypes
#16
Madeline J Pflum, Diane C Gooding
Patients with schizophrenia show performance deficits on tasks requiring empathy-related social cognition. The extent to which empathy impairments are observed in psychometric schizotypy is unclear. We compared accuracy and reaction time in three groups of individuals characterized by positive schizotypy (n = 79), negative schizotypy (n = 123), or low schizotypy group (n = 137). On a social cognition task that provided context, namely, the Emotion Perspective Taking Task, the positive schizotypes showed poorer performance than the negative schizotypy and control groups...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679838/medico-legal-investigation-in-an-explicable-case-of-congenital-central-hypoventilation-syndrome-due-to-a-rare-variant-of-the-phox2b-gene
#17
Francesco Ventura, Rosario Barranco, Tiziana Bachetti, Paolo Nozza, Ezio Fulcheri, Antonella Palmieri, Isabella Ceccherini
The heterozygous PHOX2B gene mutation is related to congenital central hypoventilation syndrome (CCHS). It is characterized by defective autonomous nervous system development leading to inadequate breathing response to hypoxia and hypercapnia, leading to hypoventilation especially during non-REM sleep, but also during waking in the more severe cases. Herein we report a case of sudden death in a 28-day-old child. The mother reported the infant was found lying on her own bed in the prone position. The infant was wearing a romper and lying in her crib without any blanket or other objects...
April 17, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29679824/extended-producer-responsibility-and-corporate-performance-effects-of-environmental-regulation-and-environmental-strategy
#18
Benhong Peng, Yu Tu, Ehsan Elahi, Guo Wei
While contemporary manufacturing technologies stimulate the industrial revolution and promote the rapidly changing global economy, it has caused enormous environmental negative externalities and managing the industrial waste remains a primary challenge, especially for fast developing countries such as China. Though existing studies explored the influence of Extended Producer Responsibility (EPR) legislations on environmental externalities, only fewer researches aimed at policy issues. Particularly, the relationship among environmental regulations, environmental strategies and corporate performance in the EPR system has not been deeply investigated...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679806/an-intelligent-dual-stimuli-responsive-photosensitizer-delivery-system-with-o-2-supplying-for-efficient-photodynamic-therapy
#19
Hongjuan Zhao, Li Li, Cuixia Zheng, Yongwei Hao, Mengya Niu, Yujie Hu, Junbiao Chang, Zhenzhong Zhang, Lei Wang
The effects of photodynamic therapy (PDT) are limited by the hypoxic tumor microenvironment (TME). In this paper, a new type of biocompatible multifunctional photosensitizer delivery system was fabricated to relieve tumor hypoxia and improve the efficacy of PDT. The photosensitizer hematoporphyrin monomethyl ether (HMME) and catalase (CAT) were encapsulated in the pores of mesoporous graphitic-phase carbon nitride nanosheets (mpg-C3 N4 ). Next, hyaluronic (HA) was coated on the surface of the mpg-C3 N4 via an amide linkage to construct the tumor-targeting HAase/CAT dual activatable and mpg-C3 N4 /HMME response photosensitizer delivery system (HA@mpg-C3 N4 -HMME/CAT)...
April 10, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29679794/multi-paratopic-vegf-decoy-receptor-have-superior-anti-tumor-effects-through-anti-egfrs-and-targeted-anti-angiogenic-activities
#20
Dae Hee Lee, Myeong Youl Lee, Youngsuk Seo, Hyo Jeong Hong, Hyun Joo An, Jong Soon Kang, Ho Min Kim
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative. Here, we developed a novel multi-paratopic VEGF decoy receptor, Cetuximab-VEGF-Grab and Trastuzumab-VEGF-Grab, by genetically fusing VEGF decoy receptor (VEGF-Grab) to a single chain Fv of anti-Epidermal Growth Factor Receptor (EGFR) antibody (Cetuximab and Trastuzumab)...
April 16, 2018: Biomaterials
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