keyword
https://read.qxmd.com/read/38546637/gpr56-in-gvl-marker-or-mechanism
#21
EDITORIAL
Audra N Iness, Pavan Bachireddy
No abstract text is available yet for this article.
March 28, 2024: Blood
https://read.qxmd.com/read/38546583/lack-of-elevated-expression-of-tgf%C3%AE-3-contributes-to-the-delay-of-epithelial-wound-healing-in-diabetic-corneas
#22
JOURNAL ARTICLE
Nan Gao, Fu-Shin Yu
PURPOSE: To investigate the mechanisms underlying the differential roles of TGFβ1 and TGFβ3 in accelerating corneal epithelial wound healing (CEWH) in diabetic (DM) corneas, with normoglycemia (NL) corneas as the control. METHODS: Two types of diabetic mice, human corneal organ cultures, mouse corneal epithelial progenitor cell lines, and bone marrow-derived macrophages (BMDMs) were employed to assess the effects of TGFβ1 and TGFβ3 on CEWH, utilizing quantitative PCR, western blotting, ELISA, and whole-mount confocal microscopy...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38546569/the-role-of-affiliation-in-the-development-of-collaborative-partner-choice
#23
JOURNAL ARTICLE
John Corbit, Hayley MacDougall, Stephanie Hartlin, Chris Moore
Collaboration is an early emerging component of successful cooperative relations that produces a cascade of positive social preferences between collaborators. Concurrently, robust preferences for affiliated others may restrict these benefits to in-group peers. We investigated how in-group affiliation (based on minimal group markers) and interpersonal affiliation (based on shared preferences) influence children's collaborative partner choice. We asked whether children prefer to collaborate with affiliated peers and if highlighting interpersonal affiliation with out-group members reduce in-group bias in partner choice...
March 28, 2024: Developmental Psychology
https://read.qxmd.com/read/38546567/prenatal-maternal-immune-activation-predicts-observed-fearfulness-in-infancy
#24
JOURNAL ARTICLE
Jishyra Serrano, Sean Womack, Catherine Yount, Sadia Firoza Chowdhury, Molly Arnold, Jessica Brunner, Zoe Duberstein, Emily S Barrett, Kristin Scheible, Richard K Miller, Thomas G O'Connor
Fear reactivity is an early emerging temperament trait that predicts longer term behavioral and health outcomes. The current analysis tests the hypothesis, an extension of prior research on maternal immune activation (MIA), that the prenatal maternal immune system is a reliable predictor of observed fear reactivity in infancy. The analysis is based on a prospective longitudinal cohort study that collected data from the first trimester and conducted observational assessments of temperament at approximately 12 months of age ( n = 281 infants)...
March 28, 2024: Developmental Psychology
https://read.qxmd.com/read/38546526/enhanced-chronic-inflammation-and-increased-branched-chain-amino-acids-in-adrenal-disorders-a-cross-sectional-study
#25
JOURNAL ARTICLE
Annop Kittithaworn A, Prerna Dogra, Jasmine Saini, Eke G Gruppen, Elizabeth Atkinson, Sara Achenbach, Kai Yu, Karthik Thangamuthu, Margery A Connelly, Robin Pf Dullaart, Irina Bancos
CONTEXT: Patients with adrenal hormone excess demonstrate increased cardiovascular risk and mortality. OBJECTIVE: We aimed to determine the impact of adrenal disorders on the inflammation marker GlycA, total branched-chain amino acids (BCAA), ketone bodies and the gut microbiome-derived metabolites trimethylamine N-oxide (TMAO) and betaine. METHODS: We conducted a single-center cross-sectional study of patients with nonfunctioning adenomas (NFA), mild autonomous cortisol secretion (MACS), primary aldosteronism (PA), Cushing syndrome (CS), pheochromocytoma/paragangliomas (PPGL), other benign or malignant adrenal masses, and adrenocortical carcinoma (ACC) between January 2015 and July 2022 (n=802)...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38546452/exploring-the-diversity-of-vaginal-microbiota-between-healthy-women-and-cervical-cancer-patients-in-india
#26
JOURNAL ARTICLE
Ashwini Kamble, Shilpa Naik, Manju Talathi, Deepali Jadhav, Meena Sakharkar, Jian Yang, Om Prakash, Ruchika Kaul-Ghanekar
Introduction. Cervicovaginal diversity has been reported as a predictive biomarker for cervical cancer risk. We recently reported the bio-therapeutic potential of vaginal probiotics from healthy Indian women against vaginal pathogens, isolated from the invasive cervical cancer (ICC) patients. Gap Statement. The cervicovaginal microflora from cervical cancer patients has not yet been reported from Indian population. Aim. The present study aimed at comparing the cervicovaginal microbiome between healthy controls (HC) and ICC patients from the Indian population...
March 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38546399/nitrosyl-heme-and-heme-iron-intake-from-processed-meats-and-risk-of-colorectal-cancer-in-the-epic-spain-cohort
#27
JOURNAL ARTICLE
Lucía Rizzolo-Brime, Leila Lujan-Barroso, Andreu Farran-Codina, Ricard Bou, Cristina Lasheras, Pilar Amiano, Amaia Aizpurua, Maria-Jose Sánchez, Esther Molina-Montes, Marcela Guevara, Conchi Moreno-Iribas, Alba Gasque, María Dolores Chirlaque-López, Sandra M Colorado-Yohar, José María Huerta, Raul Zamora-Ros, Antonio Agudo, Paula Jakszyn
BACKGROUND: The International Agency for Research on Cancer classified processed meats (PMs) as "carcinogenic" and red meat as "probably carcinogenic" for humans. The possible relationship between colorectal cancer (CRC) risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds. The aim of this study was to determine the association between nitrosyl-heme and heme iron intake and CRC risk among participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain study...
March 28, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38546394/colposcopy-referral-and-cin3-risk-of-human-papillomavirus-genotyping-strategies-in-cervical-cancer-screening
#28
JOURNAL ARTICLE
Kelsi R Kroon, Johannes A Bogaards, Daniëlle Am Heideman, Chris Jlm Meijer, Johannes Berkhof
BACKGROUND: High-risk human papillomavirus (hrHPV)-based cervical cancer screening in the Netherlands led to a substantial increase in number of colposcopy referrals and low-grade lesions detected. Genotyping strategies may be employed to lower the screening-related burden. METHODS: We evaluated fourteen triage strategies with genotyping (HPV16/18 or HPV16/18/31/33/45/52/58) for hrHPV-positive borderline or mild dyskaryosis (BMD) or normal cytology, using data from a population-based hrHPV-based screening trial with 5-year interval (POBASCAM)...
March 28, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38546373/the-association-between-hemoglobin-levels-and-renal-function-parameters-during-normothermic-machine-perfusion-a-retrospective-cohort-study-using-porcine-kidneys
#29
JOURNAL ARTICLE
L Annick van Furth, Tobias M Huijink, L Leonie van Leeuwen, Hanno Maassen, Veerle A Lantinga, Baran Ogurlu, Tim L Hamelink, Merel B F Pool, Rianne Schutter, Susanne Z J Veldhuis, Petra J Ottens, Cyril Moers, Stefan P Berger, Henri G D Leuvenink, Rene A Posma, Leonie H Venema
BACKGROUND: Ex vivo normothermic machine perfusion (NMP) is a promising tool for assessing an isolated kidney prior to transplantation. However, there is no consensus on the perfusate's optimal oxygen-carrying capacity to support renal function. To investigate the association of hemoglobin levels with renal function parameters, a retrospective analysis of isolated, normothermically, perfused porcine kidneys was performed. METHODS: Between 2015 and 2021, a total of 228 kidneys underwent 4 h of NMP with perfusates that varied in hemoglobin levels...
March 28, 2024: Artificial Organs
https://read.qxmd.com/read/38546330/coronary-artery-disease-assessment-via-on-site-ct-fractional-flow-reserve-in-patients-undergoing-transcatheter-aortic-valve-replacement
#30
JOURNAL ARTICLE
Alexandra Steyer, Valentina O Puntmann, Eike Nagel, David M Leistner, Vitali Koch, Mariuca Vasa-Nicotera, Parveen Kumar, Christian Booz, Thomas J Vogl, Silvia Mas-Peiro, Simon S Martin
Purpose To examine the clinical feasibility of workstation-based CT fractional flow reserve (CT-FFR) for coronary artery disease (CAD) evaluation during preprocedural planning in patients undergoing transcatheter aortic valve replacement (TAVR). Materials and Methods In this retrospective single-center study, 434 patients scheduled for TAVR between 2018 and 2020 were screened for study inclusion; a relevant proportion of patients (35.0% [152 of 434]) was not suitable for evaluation due to insufficient imaging properties...
April 2024: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/38546290/circ_0027791-contributes-to-the-growth-and-immune-evasion-of-hepatocellular-carcinoma-via-the-mir-496-programmed-cell-death-ligand-1-axis-in-an-m6a-dependent-manner
#31
JOURNAL ARTICLE
Furong Yu, Peifei Fang, Yonghong Fang, Daojun Chen
Emerging evidence indicates the critical roles of circular RNAs in the development of multiple cancers, containing hepatocellular carcinoma (HCC). Herein, our present research reported the biological function and mechanism of circ_0027791 in HCC progression. Circ_0027791, microRNA-496 (miR-496), programmed cell death ligand 1 (PDL1), and methyltransferase-like 3 (METTL3) levels were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Cell viability, proliferation, invasion, and sphere formation ability were detected using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, 5-ethynyl-2'-deoxyuridine, transwell, and sphere formation assays...
March 28, 2024: Environmental Toxicology
https://read.qxmd.com/read/38546286/exploring-gene-biomarkers-and-targeted-drugs-for-ferroptosis-and-cuproptosis-in-osteosarcoma-a-bioinformatic-approach
#32
JOURNAL ARTICLE
Yingnan Ji, Lv Liu, Yu Liu, Yudong Ma, Zhenhua Ji, Xiaodan Wu, Qi Zhu
Osteosarcoma predominantly affects adolescents and young adults and is characterized as a malignant bone tumor. In recent decades, substantial advancements have been achieved in both diagnosing and treating osteosarcoma. Resulting in enhanced survival rates. Despite these advancements, the intricate relationship between ferroptosis and cuproptosis genes in osteosarcoma remains inadequately understood. Leveraging TARGET and GEO datasets, we conducted Cox regression analysis to select prognostic genes from a cohort of 71 candidates...
March 28, 2024: Environmental Toxicology
https://read.qxmd.com/read/38546250/antenatally-detected-thoracic-lesions-prognosis-management-and-outcome
#33
JOURNAL ARTICLE
Md Mokarram Ali, Nilesh Tank, Monika Bawa
BACKGROUND: Foetal thoracic lesions are uncommon, with the incidence of 1 in 15,000 live births. Antenatal monitoring of these lesions is required to prognosticate the parents about the postnatal outcome of the lesions and about the well-being of the baby. Foetal ultrasound and magnetic resonance imaging (MRI) are the modalities to detect these lesions and follow-up during pregnancy and postnatally. Congenital pulmonary adenomatoid malformations (CPAM), congenital diaphragmatic hernia (CDH) and bronchopulmonary sequestrations (BPS) are the commonly detected foetal thoracic lesions...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38546158/investigation-of-the-effectiveness-of-intermittent-electromagnetic-field-stimulation-for-early-internal-cartilaginous-ossification-in-prechondrocytic-atdc5-cells
#34
JOURNAL ARTICLE
Takahiro Iwaki, Yasunobu Sawaji, Toshinori Masaoka, Eiichi Fukada, Munehiro Date, Kengo Yamamoto
Pulsed electromagnetic field (PEMF) stimulation has been widely applied clinically to promote bone healing; however, its detailed mechanism of action, particularly in endochondral ossification, remains elusive, and long-term stimulation is required for its satisfactory effect. The aim of this study was to investigate the involvement of the mammalian target of rapamycin (mTOR) pathway in chondrocyte differentiation and proliferation using a mouse prechondroblast cell line (ATDC5), and establish an efficient PEMF stimulation strategy for endochondral ossification...
March 28, 2024: Bioelectromagnetics
https://read.qxmd.com/read/38546135/heterogeneity-of-coronary-vascular-function-and-myocardial-oxygenation-in-women-with-angina-and-non-obstructive-coronary-artery-disease
#35
JOURNAL ARTICLE
Elizabeth Hillier, Malik Elharram, James A White, Todd Anderson, Judy Luu, Dina Labib, Muhammad Alhussein, Matthias G Friedrich, Louise Pilote
AIMS: Women with angina and non-obstructive coronary artery disease (ANOCA) have a heightened risk for cardiovascular events, and the pathophysiology for ischemic symptoms may be related to alterations in microvascular structure and function. We examined the use of breathing-enhanced oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) using vasoactive breathing maneuvers to assess myocardial oxygenation in women with ANOCA. METHODS AND RESULTS: We recruited women (aged 40-65 years) from two sites in Canada who presented to healthcare with persistent retrosternal chest pain and found to have ANOCA, or without a history of cardiovascular disease...
March 28, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38546132/lysosome-related-genes-and-rnf19b-as-prognostic-markers-for-survival-and-immunotherapy-efficacy-in-hepatocellular-carcinoma
#36
JOURNAL ARTICLE
Jieying Li, Hui Wang, Qian Lu, Jiayi Han, Haiyan Xu, Pingping Sun, Qiang Xu, Jianfei Huang, Juling Ji
BACKGROUND: Hepatocellular carcinoma (HCC) poses a considerable worldwide health concern due to its associated high risk of death. The heterogeneity of HCC poses challenges in developing practical risk stratification tools and identifying prognostic markers for personalized targeted treatments. Recently, lysosomes were shown to be crucial contributors to numerous cellular activities, including tumor initiation and regulating immune responses. Here, we aimed to construct a reliable prognostic signature based on lysosome-related genes and determine its association with the immune microenvironment...
March 28, 2024: Clinical and Translational Gastroenterology
https://read.qxmd.com/read/38546105/nonconventional-dysplasia-is-frequently-associated-with-goblet-cell-deficient-and-serrated-variants-of-colonic-adenocarcinoma-in-inflammatory-bowel-disease
#37
JOURNAL ARTICLE
Andrew Xiao, Masato Yozu, Bence P Kővári, Lindsay Yassan, Xiaoyan Liao, Marcela Salomao, Maria Westerhoff, Anita Sejben, Gregory Y Lauwers, Won-Tak Choi
Various subtypes of nonconventional dysplasia have been recently described in inflammatory bowel disease (IBD). We hypothesized that goblet cell deficient dysplasia and serrated dysplasia may be the primary precursor lesions for goblet cell deficient (GCDAC) and serrated (SAC) variants of colonic adenocarcinoma, respectively. Clinicopathologic features of 23 GCDAC and 10 SAC colectomy cases were analyzed. All dysplastic lesions found adjacent to the colorectal cancers (n = 22 for GCDACs and n = 10 for SACs) were subtyped as conventional, nonconventional, or mixed-type dysplasia...
March 27, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38546095/intersecting-pathways-evaluating-inflammatory-markers-and-metabolism-in-chronic-spontaneous-urticaria-with-a-multi-marker-approach
#38
JOURNAL ARTICLE
Zuhal Metin, Hanife Merve Akca, Kaan Tur, Serkan Akogul
BACKGROUND: Chronic spontaneous urticaria (CSU) is an inflammatory skin disease with intricate mechanisms. This study comprehensively assessed markers from diverse metabolic pathways, including novel inflammatory indicators, to evaluate their potential for diagnosing and monitoring CSU. MATERIALS AND METHODS: In the study involving 90 CSU patients and 90 healthy controls, the levels of albumin, high-density lipoprotein (HDL), fibrinogen, uric acid, D-dimer, C-reactive protein (CRP), and white blood cells (WBC) values were analyzed...
March 28, 2024: International Journal of Dermatology
https://read.qxmd.com/read/38546084/il-6-and-il-10-levels-in-rats-blood-plasma-as-immune-responses-post-radioiodine-i-131-administration
#39
JOURNAL ARTICLE
Harry Nugroho Eko Surniyantoro, - Abinawanto, Anom Bowolaksono, Mukh Syaifudin, Fadhillah Fadhillah, Retno Lestari, Teja Kisnanto, Dwi Ramadhani, Indra Saptiama, Iin Kurnia Hasan Basri, Triningsih Triningsih, Bisma Barron Patrianesha
OBJECTIVE: The purpose of this study was to analyze the effect of oral administration of radioiodine (I-131) on the immune responses (interleukin 6 and 10) as biodosimetry markers and to support clinical trials of I-131 solution. METHODS: The design of this study was an in vivo experimental study using twenty-seven male rats (Rattus norvegicus strain Sprague-Dawley) given 100 μL of I-131 solution at a dose of 260 μCi. Blood plasma was taken at 0.25, 0...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38546079/evaluation-of-the-cutoff-point-and-diagnostic-value-of-the-neutrophil-to-lymphocyte-ratio-in-predicting-ovarian-cancer-compared-to-pathological-findings
#40
JOURNAL ARTICLE
Maryam Sadat Hosseini, Fatemeh Amiri, Maysam Rezapour, Tahereh Ashraf Ganjoie, Farah Farzaneh, Maliheh Arab, Maryam Talayeh, Rezvaneh Beheshti Rooy, Fatemeh Hadi
PURPOSE: This research aims to establish a neutrophil-to-lymphocyte ratio (NLR) threshold and evaluate its diagnostic accuracy compared to pathological criteria for diagnosing Epithelial Ovarian Cancer (EOC). METHODS: We conducted a cross-sectional study at Imam Hossein Hospital involving 204 women aged 18 and older with confirmed ovarian mass based on pathology. We recorded clinical, pathological, and preoperative blood count data, including neutrophil-to-lymphocyte ratio (NLR)...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
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