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https://www.readbyqxmd.com/read/29230130/periampullary-carcinoma-unusual-sites-of-metastasis
#1
Anju Bansal, Varsha Dalal, Manveen Kaur, Fouzia Siraj
Background: Periampullary neoplasms include carcinomas of the duodenum, ampulla of Vater, distal common bile duct, and pancreas. The aggressive course of these neoplasms is attributable to the delay in diagnosis, as patients have no symptoms until advanced stages of the disease. More than half of patients have distant metastasis at the time of diagnosis. The most frequent sites of metastasis are the liver, lymph nodes, peritoneum, lung, bone, kidney, and, rarely the skin. Case Report: We report the case of a 45-year-old female patient with adenocarcinoma of the ampulla of Vater metastasizing to the right parietal skull with overlying cutaneous involvement 1 year after a Whipple procedure...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29217902/magnitude-severity-and-outcome-of-traumatic-pancreatic-injury-at-a-level-i-trauma-center-in-india
#2
Amit Gupta, Subodh Kumar, Sanjay Kumar Yadav, Biplab Mishra, Maneesh Singhal, Atin Kumar, Pramod Garg
Pancreatic injury is an uncommon and frequently missed injury in abdominal trauma patients. However, missed pancreatic injury is associated with significant morbidity and mortality. This study was conducted to know the burden of pancreatic injury and its outcome in our setup. A retrospective analysis of 53 patients with pancreatic injury from January 2008 through March 2012 at the Jai Prakash Narayan Apex Trauma Center (JPNATC), All India Institute of Medical Sciences (AIIMS), New Delhi. Pancreatic injuries were present in 1...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29188071/postoperative-tropheryma-whipplei-endophthalmitis-a-case-report-highlighting-the-additive-value-of-molecular-testing
#3
Julia Dick, Patrizia Krauß, Jost Hillenkamp, Britta Kohlmorgen, Christoph Schoen
Introduction.Tropheryma whipplei is the causative agent of Whipple's disease. Gastrointestinal and lymphatic tissues are affected in the majority of cases, resulting in diarrhoea, malabsorption and fever. Here, we report a rare case of ocular manifestation in a patient lacking the typical Whipple symptoms. Case presentation. A 74-year-old Caucasian female presented with blurred vision in the right eye over a period of 1-2 months, accompanied by stinging pain and conjunctival hyperaemia for the last 2 days...
October 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29154446/transmission-electron-microscopy-helpfulness-in-whipple-s-disease-masked-by-immunosuppressant-therapy-for-arthritis
#4
Alessandra Loiodice, Giuseppe Losurdo, Andrea Iannone, Roberta Rossi, Maria Grazia Fiore, Domenico Piscitelli
A 61-year-old woman received a diagnosis of undifferentiated non-erosive arthritis in 2010 and assumed methotrexate and steroids in 2014. After 1 year, she experienced watery diarrhea, vomiting, fever, weight loss, and severe hypoalbuminemia, thus being admitted into our Unit. Esophagogastroduodenoscopy showed duodenal lymphangiectasia and duodenal biopsy samples several foamy PAS-positive macrophages and villous subtotal atrophy. Transmission electron microscope demonstrated several extracellular and intracellular rod-shaped bacteria (Tropheryma whipplei)...
November 20, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29134168/anatomical-region-segmentation-for-objective-surgical-skill-assessment-with-operating-room-motion-data
#5
Yangming Li, Randall A Bly, R Alex Harbison, Ian M Humphreys, Mark E Whipple, Blake Hannaford, Kris S Moe
Background  Most existing objective surgical motion analysis schemes are limited to structured surgical tasks or recognition of motion patterns for certain categories of surgeries. Analyzing instrument motion data with respect to anatomical structures can break the limit, and an anatomical region segmentation algorithm is required for the analysis. Methods  An atlas was generated by manually segmenting the skull base into nine regions, including left/right anterior/posterior ethmoid sinuses, frontal sinus, left and right maxillary sinuses, nasal airway, and sphenoid sinus...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29112833/pancreatic-fusion-abnormality-found-during-a-whipple-procedure
#6
Bin Zhang, Xiao-Jun Yang, Zhu-Yin Qian
No abstract text is available yet for this article.
November 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29100955/bibliometric-analysis-of-authorship-trends-and-collaboration-dynamics-over-the-past-three-decades-of-bone-s-publication-history
#7
Faisal Khan, Morgan M Sandelski, Jeffrey D Rytlewski, Jennifer Lamb, Christina Pedro, Michael B N Adjei, Shatoria Lunsford, James P Fischer, Austin E Wininger, Elizabeth C Whipple, Randall T Loder, Melissa A Kacena
The existence of a gender gap in academia has been a hotly debated topic over the past several decades. It has been argued that due to the gender gap, it is more difficult for women to obtain higher positions. Manuscripts serve as an important measurement of one's accomplishments within a particular field of academia. Here, we analyzed, over the past 3 decades, authorship and other trends in manuscripts published in BONE, one of the premier journals in the field of bone and mineral metabolism. For this study, one complete year of manuscripts was evaluated (e...
October 31, 2017: Bone
https://www.readbyqxmd.com/read/29081806/pancreatic-tuberculosis-with-vascular-involvement-and-peritoneal-dissemination-in-a-young-man
#8
Meng Zhu, Ning Zhang, Wei Tao, Zhitao Wang, Shuixiang He
Pancreatic tuberculosis (TB) is an extremely rare form of extrapulmonary tuberculosis even in endemic areas that masquerades as a mass or inflammation because of lack of typical clinical manifestations and radiologic features and therefore usually misdiagnosed as a pancreatic malignancy or pancreatitis. Here we present a 23-year-old young man with pancreatic tuberculosis mimicking pancreatic head carcinoma A man who suffered from upper abdominal pain and nausea for half a month was admitted to our hospital...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29054836/formative-assessment-design-of-a-web-connected-sedentary-behavior-intervention-for-females
#9
Amber W Kinsey, Matthew Whipple, Lauren Reid, Olivia Affuso
BACKGROUND: Sedentary behavior (SB) is a significant risk factor for heart disease, diabetes, obesity, and early mortality, particularly among women, and the health consequences associated with SB are independent of physical activity status. Interventions utilizing wearable technologies can improve SB, but their effectiveness is influenced by individual preferences, device engagement strategies, and technological features, which may affect user compliance. Gathering a priori insight from target populations on their preferences for program tools and strategies may assist researchers in identifying effective methods to improve the efficacy of SB interventions...
October 20, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29051402/t-tube-biliary-drainage-during-reconstruction-after-pancreaticoduodenectomy-a-single-center-experience
#10
Pasquale Cianci, Gloria Giaracuni, Nicola Tartaglia, Alberto Fersini, Antonio Ambrosi, Vincenzo Neri
AIM: The purpose of this study is to communicate our experience about the results and effectiveness in the use of the Ttube biliary drainage during pancreaticoduodenectomy. MATERIAL OF STUDY: In accordance whit Whipple we perform the gastric antrum resection during pancreaticoduodenectomy. We have treated 42 patients with pancreaticoduodenectomy, 25 males and 17 females with a mean age of 62 years (range: 53-79 years), and in each of them we have placed a biliary T-tube...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29037321/whipple-s-disease-manifested-as-difficult-to-diagnose-polyarthralgia-a-case-report-and-literature-review
#11
Guilherme Almeida Rosa da Silva, José Soares Pires Neto
No abstract text is available yet for this article.
September 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29020602/grass-inflorescence-architecture-and-meristem-determinacy
#12
REVIEW
Peter Bommert, Clinton Whipple
The grass inflorescence is striking not only for its beauty and diversity, but also for its developmental complexity. While models of inflorescence architecture have been proposed in both eudicots and grasses, these are inadequate to fully explain the complex branching events that occur during the development of the grass inflorescence. Key to understanding grass inflorescence architecture is the meristem determinacy/indeterminacy decision, which regulates the number of branching events that occur. Here we review what has been learned about meristem determinacy from grass mutants with defects in inflorescence development...
October 8, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29019560/pancreatoduodenectomy-brazilian-practice-patterns
#13
Orlando Jorge M Torres, Eduardo de Souza M Fernandes, Rodrigo Rodrigues Vasques, Fabio Luís Waechter, Paulo Cezar G Amaral, Marcelo Bruno de Rezende, Roland Montenegro Costa, André Luís Montagnini
BACKGROUND: Pancreatoduodenectomy is a technically challenging surgical procedure with an incidence of postoperative complications ranging from 30% to 61%. The procedure requires a high level of experience, and to minimize surgery-related complications and mortality, a high-quality standard surgery is imperative. AIM: To understand the Brazilian practice patterns for pancreatoduodenectomy. METHOD: A questionnaire was designed to obtain an overview of the surgical practice in pancreatic cancer, specific training, and experience in pancreatoduodenectomy...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28991077/surveillance-of-duodenal-polyposis-in-familial-adenomatous-polyposis-should-the-spigelman-score-be-modified
#14
EDITORIAL
Isabelle Sourrouille, Jérémie H Lefèvre, Conor Shields, Chrystelle Colas, Jerôme Bellanger, Benoît Desaint, Francois Paye, Emmanuel Tiret, Yann Parc
BACKGROUND: Duodenal polyposis is a manifestation of adenomatous polyposis that predisposes to duodenal or ampullary adenocarcinoma. Duodenal polyposis is monitored by upper GI endoscopies and may require iterative resections and prophylactic radical surgical treatment when malignancy is threatening. OBJECTIVE: The purpose of this study was to evaluate severity scoring for surveillance and treatment in a large series of duodenal polyposis. DESIGN: From 1982 to 2014, every patient surveyed by upper GI endoscopies for duodenal polyposis was included...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28989869/-riding-high-on-low-fuel-our-experience-with-endogenous-hyperinsulinemic-hypoglycemia
#15
P R Manjunath, Belinda George, Vivek Mathew, Ganapathi Bantwal, Vageesh Ayyar
INTRODUCTION: Endogenous hyperinsulinemic hypoglycemia (EHH) is a condition in which the insulin levels are inappropriately high in the presence of low plasma glucose. MATERIALS AND METHODS: We did a retrospective analysis of case records of those patients admitted and evaluated for EHH from June 2004 to June 2016 in our center, excluding those that were diagnosed with reactive hypoglycemia. We collected data regarding demographics, clinical presentation, laboratory results, localization techniques, and treatment administered...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28975996/laparoscopic-pancreaticoduodenectomy-for-tumors-of-the-head-of-pancreas-10-cases-for-a-single-center-experience
#16
F Caruso, G Alessandri, G Cesana, G Castello, M Uccelli, F Ciccarese, R Giorgi, R Villa, B Scotto, S Olmi
OBJECTIVE: The tumors of the head of the pancreas are one of the leading causes of cancer-related death in Western countries. The current gold standard for these tumors is a Whipple procedure. This procedure did not change in its surgical steps since when it was initially introduced in 1935. More recently, a laparoscopic approach with similar outcomes has been described. The aim of this paper is to describe the laparoscopic surgical technique performed in our unit, reporting single center postoperative outcomes...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28973879/tree-genetics-defines-fungal-partner-communities-that-may-confer-drought-tolerance
#17
Catherine A Gehring, Christopher M Sthultz, Lluvia Flores-Rentería, Amy V Whipple, Thomas G Whitham
Plant genetic variation and soil microorganisms are individually known to influence plant responses to climate change, but the interactive effects of these two factors are largely unknown. Using long-term observational studies in the field and common garden and greenhouse experiments of a foundation tree species (Pinus edulis) and its mutualistic ectomycorrhizal fungal (EMF) associates, we show that EMF community composition is under strong plant genetic control. Seedlings acquire the EMF community of their seed source trees (drought tolerant vs...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28973620/effect-of-genotype-guided-warfarin-dosing-on-clinical-events-and-anticoagulation-control-among-patients-undergoing-hip-or-knee-arthroplasty-the-gift-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Brian F Gage, Anne R Bass, Hannah Lin, Scott C Woller, Scott M Stevens, Noor Al-Hammadi, Juan Li, Tomás Rodríguez, J Philip Miller, Gwendolyn A McMillin, Robert C Pendleton, Amir K Jaffer, Cristi R King, Brandi DeVore Whipple, Rhonda Porche-Sorbet, Lynnae Napoli, Kerri Merritt, Anna M Thompson, Gina Hyun, Jeffrey L Anderson, Wesley Hollomon, Robert L Barrack, Ryan M Nunley, Gerard Moskowitz, Victor Dávila-Román, Charles S Eby
Importance: Warfarin use accounts for more medication-related emergency department visits among older patients than any other drug. Whether genotype-guided warfarin dosing can prevent these adverse events is unknown. Objective: To determine whether genotype-guided dosing improves the safety of warfarin initiation. Design, Setting, and Patients: The randomized clinical Genetic Informatics Trial (GIFT) of Warfarin to Prevent Deep Vein Thrombosis included patients aged 65 years or older initiating warfarin for elective hip or knee arthroplasty and was conducted at 6 US medical centers...
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28970734/how-to-treat-intestinal-obstruction-due-to-malignant-recurrence-after-whipple-s-resection-for-pancreatic-head-cancer-description-of-2-new-endoscopic-techniques
#19
Christina Mouradides, Alaa Taha, Ivan Borbath, Pierre H Deprez, Tom G Moreels
The prognosis of pancreatic cancer remains poor, even after initial surgical therapy. Local recurrence after Whipple's pancreatico-duodenectomy may lead to intestinal obstruction at the level of the afferent limb or the alimentary limb. Endoscopic insertion of a self-expandable metal stent (SEMS) into the intestinal malignant stricture is the preferred method of choice for palliation. We describe two new endoscopic techniques to treat a malignant intestinal obstruction with the insertion of a SEMS into the afferent limb and the alimentary limb...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28966453/an-unusual-presentation-of-tropheryma-whipplei-infection
#20
Trace Heavener, Michelle Thompson, Chhaya Patel, Lisa Forrester, Donald Rawls
Whipple's disease is an infection caused by the Gram-positive bacillus Tropheryma whipplei. Invasion or uptake of the bacteria can occur in various parts of the body. The differential diagnoses are broad due to the wide spectrum of infection, and the disease is diagnosed based on biopsy of suspected lesions, usually in the small intestine. We present the case of a 56-year-old man with no significant prior medical history who presented with swelling and pain in the left eye. Review of systems revealed 6 months of persistent diarrhea, and intestinal biopsy revealed periodic acid-Schiff-positive macrophages...
October 2017: Proceedings of the Baylor University Medical Center
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