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https://www.readbyqxmd.com/read/27901245/transcranial-direct-current-stimulation-for-treatment-resistant-obsessive-compulsive-disorder-report-on-two-cases-and-proposal-for-a-randomized-sham-controlled-trial
#1
Renata de Melo Felipe da Silva, André Russowsky Brunoni, Eurípedes Constantino Miguel, Roseli Gedanke Shavitt
CONTEXT AND OBJECTIVE: Neuromodulation techniques for treating obsessive-compulsive disorder (OCD) have expanded through greater understanding of the brain circuits involved in this disorder. Transcranial direct current stimulation (tDCS), a non-invasive technique, has been studied as an alternative for treatment-resistant OCD. We describe the design of a clinical trial using tDCS for OCD and report on the outcomes from two patients with primary OCD who were resistant to cognitive-behavioral therapy and to selective serotonin reuptake inhibitors, and who received tDCS in an open manner during the training phase for the study procedures...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27885309/transcranial-direct-current-stimulation-use-in-the-treatment-of-neuropsychiatric-disorders-a-brief-review
#2
Sarah M Szymkowicz, Molly E McLaren, Uma Suryadevara, Adam J Woods
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has grown in popularity over the past two decades as an alternative treatment option for various neuropsychiatric disorders. tDCS modulates cortical excitability through the application of a weak direct current to the scalp via electrodes placed over cortical regions of interest. It has been shown to be a promising and relatively safe treatment tool with few adverse events. In this article, we will briefly review the efficacy of tDCS in depression, bipolar disorder, schizophrenia, and obsessive-compulsive disorder...
November 2016: Psychiatric Annals
https://www.readbyqxmd.com/read/27802585/transcranial-direct-current-stimulation-for-obsessive-compulsive-disorder-a-randomized-controlled-partial-crossover-trial
#3
Giordano D'Urso, Andre R Brunoni, Maria Pia Mazzaferro, Annalisa Anastasia, Andrea de Bartolomeis, Antonio Mantovani
BACKGROUND: Presupplementary motor area (pre-SMA) hyperactivity has been detected in obsessive-compulsive disorder (OCD) patients. However, it is not understood whether this is a putative primary cause or a compensatory mechanism in OCD pathophysiology. Considering the polarity-dependent effects on cortical excitability of transcranial direct current stimulation (tDCS), we applied cathodal and/or anodal tDCS to the pre-SMA of OCD patients to test which current polarity might better improve symptoms...
November 1, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27044999/the-heart-side-of-brain-neuromodulation
#4
REVIEW
Simone Rossi, Emiliano Santarnecchi, Gaetano Valenza, Monica Ulivelli
Neuromodulation refers to invasive, minimally invasive or non-invasive techniques to stimulate discrete cortical or subcortical brain regions with therapeutic purposes in otherwise intractable patients: for example, thousands of advanced Parkinsonian patients, as well as patients with tremor or dystonia, benefited by deep brain stimulation (DBS) procedures (neural targets: basal ganglia nuclei). A new era for DBS is currently opening for patients with drug-resistant depression, obsessive-compulsive disorders, severe epilepsy, migraine and chronic pain (neural targets: basal ganglia and other subcortical nuclei or associative fibres)...
May 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/26765514/a-systematic-review-of-the-clinical-efficacy-of-transcranial-direct-current-stimulation-tdcs-in-psychiatric-disorders
#5
REVIEW
Maria Kekic, Elena Boysen, Iain C Campbell, Ulrike Schmidt
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique, which can be used to selectively disrupt patterns of neural activity that are associated with symptoms of mental illness. tDCS has been implemented in numerous therapeutic trials across a range of patient populations, with a rapidly increasing number of studies being published each year. This systematic review aimed to evaluate the efficacy of tDCS in the treatment of psychiatric disorders. Four electronic databases were searched from inception until December 2015 by two independent reviewers, and 66 eligible studies were identified...
March 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/25982412/transcranial-direct-current-stimulation-in-obsessive-compulsive-disorder-emerging-clinical-evidence-and-considerations-for-optimal-montage-of-electrodes
#6
REVIEW
Natasha M Senço, Yu Huang, Giordano D'Urso, Lucas C Parra, Marom Bikson, Antonio Mantovani, Roseli G Shavitt, Marcelo Q Hoexter, Eurípedes C Miguel, André R Brunoni
BACKGROUND: Neuromodulation techniques for obsessive-compulsive disorder (OCD) treatment have expanded with greater understanding of the brain circuits involved. Transcranial direct current stimulation (tDCS) might be a potential new treatment for OCD, although the optimal montage is unclear. OBJECTIVE: To perform a systematic review on meta-analyses of repetitive transcranianal magnetic stimulation (rTMS) and deep brain stimulation (DBS) trials for OCD, aiming to identify brain stimulation targets for future tDCS trials and to support the empirical evidence with computer head modeling analysis...
July 2015: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/25971992/polarity-dependent-effects-of-transcranial-direct-current-stimulation-in-obsessive-compulsive-disorder
#7
Giordano D'Urso, Andre Russowsky Brunoni, Annalisa Anastasia, Marco Micillo, Andrea de Bartolomeis, Antonio Mantovani
About one third of patients with obsessive-compulsive disorder (OCD) fail to experience significant clinical benefit from currently available treatments. Hyperactivity of the presupplementary motor area (pre-SMA) has been detected in OCD patients, but it is not clear whether it is the primary cause or a secondary compensatory mechanism in OCD pathophysiology. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique with polarity-dependent effects on motor cortical excitability...
2016: Neurocase
https://www.readbyqxmd.com/read/25825002/transcranial-cortical-stimulation-in-the-treatment-of-obsessive-compulsive-disorders-efficacy-studies
#8
REVIEW
Ghassen Saba, Albert Moukheiber, Antoine Pelissolo
Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation methods that became widely used as therapeutic tools during the past two decades especially in cases of depression and schizophrenia. Low frequency rTMS and cathodal effect of tDCS inhibits cortical functioning while high frequency and anodal effect of tDCS have the opposite effect. Prolonged and repetitive application of either methods leads to changes in excitability of the human cortex that outlast the period of stimulation...
May 2015: Current Psychiatry Reports
https://www.readbyqxmd.com/read/25815258/transcranial-direct-current-stimulation-in-psychiatric-disorders
#9
REVIEW
Gabriel Tortella, Roberta Casati, Luana V M Aparicio, Antonio Mantovani, Natasha Senço, Giordano D'Urso, Jerome Brunelin, Fabiana Guarienti, Priscila Mara Lorencini Selingardi, Débora Muszkat, Bernardo de Sampaio Pereira Junior, Leandro Valiengo, Adriano H Moffa, Marcel Simis, Lucas Borrione, André R Brunoni
The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation (tDCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder...
March 22, 2015: World Journal of Psychiatry
https://www.readbyqxmd.com/read/25651393/efficacy-of-cathodal-transcranial-direct-current-stimulation-over-the-left-orbitofrontal-cortex-in-a-patient-with-treatment-resistant-obsessive-compulsive-disorder
#10
Marine Mondino, Frédéric Haesebaert, Emmanuel Poulet, Mohamed Saoud, Jérôme Brunelin
Obsessive-compulsive disorder (OCD) is a disabling and frequent neuropsychiatric disorder. Forty percent to 60% of patients with OCD fail to respond to available treatments. Neuroimaging studies have highlighted an association between the severity of obsessive and compulsive symptoms and an increased activity of the left orbitofrontal cortex (OFC) in patients with OCD. Transcranial direct current stimulation (tDCS) is a powerful and easy-to-use tool to modulate brain activity. Cathodal tDCS (c-tDCS) is assumed to decrease cortical excitability in the targeted brain region...
December 2015: Journal of ECT
https://www.readbyqxmd.com/read/25150569/neuromodulation-in-obsessive-compulsive-disorder
#11
REVIEW
Melisse Bais, Martijn Figee, Damiaan Denys
Neuromodulation techniques in obsessive-compulsive disorder (OCD) involve electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS). This article reviews the available literature on the efficacy and applicability of these techniques in OCD. ECT is used for the treatment of comorbid depression or psychosis. One case report on tDCS showed no effects in OCD. Low-frequency TMS provides significant but mostly transient improvement of obsessive-compulsive symptoms...
September 2014: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/24447054/can-transcranial-direct-current-stimulation-tdcs-alleviate-symptoms-and-improve-cognition-in-psychiatric-disorders
#12
REVIEW
Marine Mondino, Djamila Bennabi, Emmanuel Poulet, Filipe Galvao, Jerome Brunelin, Emmanuel Haffen
OBJECTIVES: Since the discovery of psychopharmacological treatments in the early 1950s, followed by the development of second-generation antidepressants and antipsychotics, biological psychiatry has not achieved much progress. Recent technological advances in the field of non-invasive brain stimulation open new perspectives in the treatment of psychiatric disorders. Amongst them, transcranial direct current stimulation (tDCS) modulates cortical excitability and induces long-lasting effects...
May 2014: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/22893803/brain-stimulation-in-posttraumatic-stress-disorder
#13
Vladan Novakovic, Leo Sher, Kyle A B Lapidus, Janet Mindes, Julia A Golier, Rachel Yehuda
Posttraumatic stress disorder (PTSD) is a complex, heterogeneous disorder that develops following trauma and often includes perceptual, cognitive, affective, physiological, and psychological features. PTSD is characterized by hyperarousal, intrusive thoughts, exaggerated startle response, flashbacks, nightmares, sleep disturbances, emotional numbness, and persistent avoidance of trauma-associated stimuli. The efficacy of available treatments for PTSD may result in part from relief of associated depressive and anxiety-related symptoms in addition to treatment of core symptoms that derive from reexperiencing, numbing, and hyperarousal...
2011: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/22554168/modulation-of-affective-symptoms-and-resting-state-activity-by-brain-stimulation-in-a-treatment-resistant-case-of-obsessive-compulsive-disorder
#14
C Volpato, F Piccione, M Cavinato, D Duzzi, S Schiff, L Foscolo, A Venneri
The effect of transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) on psychopathological symptoms and resting state brain activity was assessed in a patient with obsessive-compulsive disorder (OCD). tDCS and rTMS had no effect on OC symptoms. tDCS, however, improved depression and anxiety. Functional magnetic resonance imaging at baseline showed an interhemispheric asymmetry with hyperactivation of the left and hypoactivation of the right anterior neural circuits...
August 2013: Neurocase
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