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https://www.readbyqxmd.com/read/29559020/gene-polymorphisms-and-response-to-transcranial-direct-current-stimulation-for-auditory-verbal-hallucinations-in-schizophrenia
#1
Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29552509/effects-of-transcranial-direct-current-stimulation-on-working-memory-and-negative-symptoms-in-schizophrenia-a-phase-ii-randomized-sham-controlled-trial
#2
J S Gomes, A P Trevizol, D V Ducos, A Gadelha, B B Ortiz, A O Fonseca, H T Akiba, C C Azevedo, L S P Guimaraes, P Shiozawa, Q Cordeiro, A Lacerda, A M Dias
Background: The lack of efficacy of pharmacological treatments for cognitive and negative symptoms in schizophrenia highlights the need for new interventions. We investigated the effects of tDCS on working memory and negative symptoms in patients with schizophrenia. Method: Double-blinded, randomized, sham-controlled clinical trial, investigating the effects of 10 sessions of tDCS in schizophrenia subjects. Stimulation used 2 mA, for 20 min, with electrodes of 25 cm2 wrapped in cotton material soaked in saline solution...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29533819/randomized-trial-of-transcranial-alternating-current-stimulation-for-treatment-of-auditory-hallucinations-in-schizophrenia
#3
Juliann M Mellin, Sankaraleengam Alagapan, Caroline Lustenberger, Courtney E Lugo, Morgan L Alexander, John H Gilmore, L Fredrik Jarskog, Flavio Fröhlich
BACKGROUND: Approximately 30% of patients with schizophrenia experience auditory hallucinations that are refractory to antipsychotic medications. Here, we evaluated the feasibility and efficacy of transcranial alternating current stimulation (tACS) that we hypothesized would improve auditory hallucination symptoms by enhancing synchronization between the frontal and temporo-parietal areas of the left hemisphere. METHOD: 22 participants were randomized to one of three arms and received twice daily, 20 min sessions of sham, 10 Hz 2 mA peak-to-peak tACS, or 2 mA tDCS over the course of 5 consecutive days...
March 10, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29471017/moderate-effects-of-noninvasive-brain-stimulation-of-the-frontal-cortex-for-improving-negative-symptoms-in-schizophrenia-meta-analysis-of-controlled-trials
#4
REVIEW
André Aleman, Stefanie Enriquez-Geppert, Henderikus Knegtering, Jozarni J Dlabac-de Lange
BACKGROUND: Negative symptoms in schizophrenia concern a clinically relevant reduction of goal-directed behavior that strongly and negatively impacts daily functioning. Existing treatments are of marginal effect and novel approaches are needed. Noninvasive neurostimulation by means of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are novel approaches that may hold promise. OBJECTIVES: To provide a quantitative integration of the published evidence regarding effects of rTMS and tDCS over the frontal cortex on negative symptoms, including an analysis of effects of sham stimulation...
February 19, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29413808/efficacy-of-non-invasive-brain-stimulation-on-the-symptom-dimensions-of-schizophrenia-a-meta-analysis-of-randomized-controlled-trials
#5
Nigel I Kennedy, Won Hee Lee, Sophia Frangou
BACKGROUND: Transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) have shown promise in the treatment of schizophrenia. OBJECTIVE: To quantify the efficacy of double-blind randomized controlled trials (RCT) of tDCS and rTMS for the positive and negative symptoms of schizophrenia and identify significant moderators relating to patient-related features and stimulation parameters. METHODS: Systemic review and meta-analyses of the relevant literature published until February 1st, 2017 to assess treatment efficacy and quantify the contribution of potential moderator variables...
January 27, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29397282/non-invasive-brain-stimulation-for-negative-symptoms-in-schizophrenia-an-updated-systematic-review-and-meta-analysis
#6
REVIEW
Caio Osoegawa, July Silveira Gomes, Ruth Bartelli Grigolon, Elisa Brietzke, Ary Gadelha, Acioly L T Lacerda, Álvaro Machado Dias, Quirino Cordeiro, Ronaldo Laranjeira, Danilo de Jesus, Zafiris Jeff Daskalakis, Jerome Brunelin, Joachim Cordes, Alisson Paulino Trevizol
BACKGROUND: Schizophrenia is a mental disorder with significant socioeconomic burden. Although current pharmacological treatments are effective for treating positive symptoms, medications have little-to-no effect in the treatment of negative symptoms. OBJECTIVE: To assess the efficacy of non-invasive brain stimulation (NIBS) for negative symptoms in schizophrenia in randomized clinical trials (RCTs). METHODS: A systematic review in Medline and Cochrane Library databases was performed up to May 31, 2017...
January 31, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29284822/right-sided-transcranial-direct-current-stimulation-and-attentional-salience-of-auditory-hallucinations-in-schizophrenia
#7
Damodharan Dinakaran, Rujuta Parlikar, Vanteemar S Sreeraj, Anuradha Neikar, Sachin Nagendrappa, Venkataram Shivakumar, Ganesan Venkatasubramanian
Transcranial direct current stimulation (tDCS) is a safe, noninvasive technique demonstrated to reduce persistent auditory hallucinations in patients with schizophrenia. Here, we report the differential effect of tDCS on auditory hallucinations against other positive symptoms and also the use of right-sided tDCS in patients with increased attentional salience toward auditory hallucinations.
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29259147/feasibility-and-clinical-utility-of-high-definition-transcranial-direct-current-stimulation-in-the-treatment-of-persistent-hallucinations-in-schizophrenia
#8
A Bose, V Shivakumar, H Chhabra, R Parlikar, V S Sreeraj, D Dinakaran, J C Narayanaswamy, G Venkatasubramanian
Persistent auditory verbal hallucination is a clinically significant problem in schizophrenia. Recent studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in treatment. An optimised version of tDCS, namely high-definition tDCS (HD-tDCS), uses smaller electrodes arranged in a 4x1 ring configuration and may offer more focal and predictable neuromodulation than conventional tDCS. This case report illustrates the feasibility and clinical utility of add-on HD-tDCS over the left temporoparietal junction in a 4x1 ring configuration to treat persistent auditory verbal hallucination in schizophrenia...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29243532/use-of-transcranial-direct-stimulation-in-the-treatment-of-negative-symptoms-of-schizophrenia
#9
Maria Pontillo, Floriana Costanzo, Deny Menghini, Roberto Averna, Ornella Santonastaso, Maria Cristina Tata, Stefano Vicari
Schizophrenia is a debilitating disease that affects approximately 1% of the population. Negative symptoms are among the major determinants of the functional impairment and a significant proportion of patients with negative symptoms will continue to experience these symptoms despite antipsychotic medications. There are promising results in the application of brain stimulation, particularly transcranial direct current stimulation (tDCS), for the reduction of negative symptoms of schizophrenia. However, findings are still controversial...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29241672/catatonia-with-schizophrenia-from-ect-to-rtms
#10
E Stip, M-E Blain-Juste, O Farmer, M-P Fournier-Gosselin, P Lespérance
BACKGROUND: Electroconvulsive therapy is indicated in cases of catatonic schizophrenia following a failure of the challenge test with lorazepam or Zolpidem® . Some patients need maintenance treatment with ECT. Repetitive Transcranial Magnetic Stimulation (rTMS) and anodal Transcranial direct-current stimulation (tDCS) might be effective against catatonia. OBJECTIVE: Consider an alternative to ECT for a refractory patient. REVIEW: Twenty-one articles were identified mainly based on case reports series were found using search on Medline, Google Scholar, PsychInfo, CAIRNS...
December 11, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29238310/parameter-based-evaluation-of-attentional-impairments-in-schizophrenia-and-their-modulation-by-prefrontal-transcranial-direct-current-stimulation
#11
Nadine Gögler, Irina Papazova, Tatiana Oviedo-Salcedo, Nina Filipova, Wolfgang Strube, Johanna Funk, Hermann J Müller, Kathrin Finke, Alkomiet Hasan
Background: Attentional dysfunctions constitute core cognitive symptoms in schizophrenia, but the precise underlying neurocognitive mechanisms remain to be elucidated. Methods: In this randomized, double-blind, sham-controlled study, we applied, for the first time, a theoretically grounded modeling approach based on Bundesen's Theory of Visual Attention (TVA) to (i) identify specific visual attentional parameters affected in schizophrenia and (ii) assess, as a proof of concept, the potential of single-dose anodal transcranial direct current stimulation (tDCS; 20 min, 2 mA) to the left dorsolateral prefrontal cortex to modulate these attentional parameters...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29200573/neural-effects-of-transcranial-direct-current-stimulation-in-schizophrenia-a-case-study-using-functional-near-infrared-spectroscopy
#12
S Trevor Taylor, Harleen Chhabra, Vanteemar S Sreeraj, Venkataram Shivakumar, Sunil V Kalmady, Ganesan Venkatasubramanian
Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%-80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%-30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29180969/effect-of-transcranial-direct-current-stimulation-on-functional-capacity-in-schizophrenia-a-study-protocol-for-a-randomized-controlled-trial
#13
Zui Narita, Takuma Inagawa, Kazushi Maruo, Kazuki Sueyoshi, Tomiki Sumiyoshi
Schizophrenia patients elicit a wide range of psychopathology, including psychotic symptoms, mood symptoms, and cognitive impairment. Functional capacity is defined as the ability to perform everyday living skills, which is linked to cognition and real-world functional outcome. In a previous open trial, we demonstrated that transcranial direct current stimulation (tDCS), one of the neuromodulation methods, improved cognition and functional capacity in 28 patients with schizophrenia. However, since it was a pilot study, a controlled trial is needed...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29077136/-non-invasive-brain-stimulation-in-schizophrenia-hallucinations-and-negative-symptoms
#14
A Aleman, J Brummelman, J J Dlabac-de Lange, S Koops, H Knegtering, S F W Neggers, I E Sommer
New approaches are needed in the treatment of characteristic symptoms of schizophrenia such as hallucinations and negative symptoms. Non-invasive brain stimulation can make a useful contribution.<br/> AIM: To discuss the published evidence regarding efficacy and safety of repetitive transcranial magnetic stimulation (rtms) and transcranial direct current stimulation (tdcs) when used in the treatment of auditory verbal hallucinations and negative symptoms.<br/> METHOD: We review and discuss recent meta-analyses and we analyse relevant factors...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29033856/possible-facilitative-effects-of-repeated-anodal-transcranial-direct-current-stimulation-on-functional-outcome-1-month-later-in-schizophrenia-an-open-trial
#15
Zui Narita, Takuma Inagawa, Kazuki Sueyoshi, Crystal Lin, Tomiki Sumiyoshi
Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for 5 consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29021765/enhancing-neuroplasticity-to-augment-cognitive-remediation-in-schizophrenia
#16
REVIEW
Carol Jahshan, Yuri Rassovsky, Michael F Green
There is a burgeoning need for innovative treatment strategies to improve the cognitive deficits in schizophrenia. Cognitive remediation (CR) is effective at the group level, but the variability in treatment response is large. Given that CR may depend on intact neuroplasticity to produce cognitive gains, it is reasonable to combine it with strategies that harness patients' neuroplastic potential. In this review, we discuss two non-pharmacological approaches that can enhance neuroplasticity and possibly augment the effects of CR in schizophrenia: physical exercise and transcranial direct current stimulation (tDCS)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28866447/efficacy-of-fronto-temporal-transcranial-direct-current-stimulation-for-refractory-auditory-verbal-hallucinations-in-schizophrenia-a-randomized-double-blind-sham-controlled-study
#17
Anushree Bose, Venkataram Shivakumar, Sri Mahavir Agarwal, Sunil V Kalmady, Sonia Shenoy, Vanteemar S Sreeraj, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Persistent auditory verbal hallucinations (AVH) that are refractory to antipsychotic medications are reported in about 20-30% of schizophrenia patients. Transcranial Direct Current Stimulation (tDCS), a non-invasive and safe neuromodulatory technique, has attracted significant interest as an add-on treatment for refractory AVH in schizophrenia. Studies examining the efficacy of tDCS for refractory AVH in schizophrenia have reported inconsistent findings. In this study, using a randomized, double-blind, sham-controlled design (RCT), we sought to examine the effect of add-on tDCS [anode corresponding to left dorsolateral prefrontal cortex and cathode to left temporo-parietal junction; 2-mA, twice-daily sessions for 5-days] to treat refractory AVH in schizophrenia patients (N=25); following this RCT phase, patients that had <30% reduction in AVH severity were offered an open-label extension (OLE) active stimulation to evaluate the effect of cross-over to verum tDCS...
August 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28864916/effects-of-transcranial-direct-current-stimulation-on-the-auditory-mismatch-negativity-response-and-working-memory-performance-in-schizophrenia-a-pilot-study
#18
Danielle Impey, Ashley Baddeley, Renee Nelson, Alain Labelle, Verner Knott
Cognitive impairment has been proposed to be the core feature of schizophrenia (Sz). Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation which can improve cognitive function in healthy participants and in psychiatric patients with cognitive deficits. tDCS has been shown to improve cognition and hallucination symptoms in Sz, a disorder also associated with marked sensory processing deficits. Recent findings in healthy controls demonstrate that anodal tDCS increases auditory deviance detection, as measured by the brain-based event-related potential, mismatch negativity (MMN), which is a putative biomarker of Sz that has been proposed as a target for treatment of Sz cognition...
November 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28687908/the-effect-of-bilateral-transcranial-direct-current-stimulation-on-early-auditory-processing-in-schizophrenia-a-preliminary-study
#19
Walter Dunn, Yuri Rassovsky, Jonathan Wynn, Allan D Wu, Marco Iacoboni, Gerhard Hellemann, Michael F Green
Transcranial direct current stimulation (tDCS) was applied bilaterally over the auditory cortex in 12 schizophrenia patients to modulate early auditory processing. Performance on a tone discrimination task (tone-matching task-TMT) and auditory mismatch negativity were assessed after counterbalanced anodal, cathodal, and sham tDCS. Cathodal stimulation improved TMT performance (p < 0.03) compared to sham condition. Post-hoc analyses revealed a stimulation condition by negative symptom interaction in which greater negative symptoms were associated with a better TMT performance after anodal tDCS...
July 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28638205/effects-of-transcranial-direct-current-stimulation-tdcs-for-auditory-hallucinations-a-systematic-review
#20
Haibin Li, Yiran Wang, Jiangling Jiang, Wei Li, Chunbo Li
BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasion brain stimulation, which has been suggested as a safe and promising treatment for auditory hallucinations, however, no systematic review has been conducted to evaluate the effects of tDCS on auditory hallucinations (AH). OBJECTIVE: To investigate the efficacy and safety of tDCS for auditory hallucinations among patients with schizophrenia. METHODS: We searched relevant randomized controlled trials (RCTs) from PubMed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chongqing VIP database for Chinese Technical Periodicals, WANFANG DATA, Chinese Biological Medical Literature Database, and Taiwan Electronic Periodical Services (TEPS) before February 13, 2016...
December 25, 2016: Shanghai Archives of Psychiatry
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