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https://www.readbyqxmd.com/read/29222739/effects-of-two-aerobic-exercise-training-protocols-on-parameters-of-oxidative-stress-in-the-blood-and-liver-of-obese-rats
#1
Daniela Delwing-de Lima, Ariene Sampaio Souza Farias Ulbricht, Carla Werlang-Coelho, Débora Delwing-Dal Magro, Victor Hugo Antonio Joaquim, Eloise Mariani Salamaia, Silvana Rodrigues de Quevedo, Larissa Desordi
We evaluated the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) protocols on the alterations in oxidative stress parameters caused by a high-fat diet (HFD), in the blood and liver of rats. The HFD enhanced thiobarbituric acid reactive substances (TBA-RS) and protein carbonyl content, while reducing total sulfhydryl content and catalase (CAT) and glutathione peroxidase (GSH-Px) activities in the blood. Both training protocols prevented an increase in TBA-RS and protein carbonyl content, and prevented a reduction in CAT...
December 8, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29220476/egenpub-a-text-mining-system-for-extending-computationally-mapped-bibliography-for-uniprot-knowledgebase-by-capturing-centrality
#2
Ruoyao Ding, Emmanuel Boutet, Damien Lieberherr, Michel Schneider, Michael Tognolli, Cathy H Wu, K Vijay-Shanker, Cecilia N Arighi
UniProt Knowledgebase (UniProtKB) is a publicly available database with access to a vast amount of protein sequence and functional information. To widen the scope of the publications associated with a protein entry, UniProt has introduced the computationally mapped additional bibliography section, which includes literature collected from external sources. In this article, we describe a text mining system, eGenPub, which selects articles that are 'about' specific proteins and allows automatic identification of additional bibliography for given UniProt protein entries...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29220206/aerobic-training-but-no-resistance-training-increases-sirt3-in-skeletal-muscle-of-sedentary-obese-male-adolescents
#3
Katya Vargas-Ortiz, Victoriano Pérez-Vázquez, Arturo Figueroa, Francisco J Díaz, Paulina G Montaño-Ascencio, Maciste H Macías-Cervantes
In recent years, prevalence of obesity in children and adolescents has increased. A strategy for prevention and management of obesity is aerobic training (AT) due to its effectiveness to decrease fat mass. AT increases the content of SIRT3, a mitochondrial protein that increases the expression of PGC-1α and NFR1, thereby enhances mitochondrial function and metabolic health. Resistance training (RT) provides metabolic benefits but its effect on SIRT3 content is unknown. To compare the effect of AT and RT on SIRT3, PGC-1α and NRF-1 protein levels in skeletal muscle of sedentary obese adolescents...
December 8, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29216185/a-cyber-linked-undergraduate-research-experience-in-computational-biomolecular-structure-prediction-and-design
#4
Rebecca F Alford, Andrew Leaver-Fay, Lynda Gonzales, Erin L Dolan, Jeffrey J Gray
Computational biology is an interdisciplinary field, and many computational biology research projects involve distributed teams of scientists. To accomplish their work, these teams must overcome both disciplinary and geographic barriers. Introducing new training paradigms is one way to facilitate research progress in computational biology. Here, we describe a new undergraduate program in biomolecular structure prediction and design in which students conduct research at labs located at geographically-distributed institutions while remaining connected through an online community...
December 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29215751/proteomic-response-of-the-rat-liver-in-differential-swimming-modes
#5
Liang Chen, Yanhua Yang, Yiting Wang, Lipeng Qiu, Hengchuan Xia, Aiai Wang, Hailong Liu, Hongfei Shi, Keping Chen
Moderate exercise helps improve competition results, providing a balanced muscle tone and biochemical activity, whereas excessive training disrupts the balance between training and recovery, causes harm to the organism, and leads to overtraining syndrome (OTS). To explore the mechanisms of different protein expressions during training and acquisition of immunity, we used proteomic analyses to investigate the differences of liver-protein expressions between two swimming modes. Sprague-Dawley rats were randomly divided into control (CT), fatigue training (FT), and exhaustive training (ET) groups, and liver tissues from each group were subjected to two-dimensional electrophoresis (2DE)...
December 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29214924/different-protein-and-derivatives-supplementation-strategies-combined-with-resistance-training-in-pre-frail-and-frail-elderly-rationale-and-protocol-for-the-pro-elderly-study
#6
Alan Lins Fernandes, Ana Paula Hayashi, José Claudio Jambassi-Filho, Mariana Dutilh de Capitani, Davi Alves de Santana, Bruno Gualano, Hamilton Roschel
BACKGROUND: Frailty is a multifactorial geriatric syndrome characterized by progressive decline in health and associated with decreased muscle mass, strength, and functional capacity. Resistance training (RT) combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related impairments. AIM: To investigate the chronic effects of different strategies of protein and derivatives supplementation in association with RT on selected health-related parameters in pre-frail and frail elderly...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29214669/tooth-loss-and-its-relationship-with-protein-intake-by-elderly-brazilians-a-structural-equation-modelling-approach
#7
Rafael A Bomfim, Luciana B de Souza, José E Corrente
OBJECTIVE: This study aimed at assessing the relationship between self-perceived tooth loss and wearing dentures, on the one hand, and the consumption of protein, on the other hand, among the elderly population of Botucatu, SP. Food consumption tends to decrease with ageing, especially protein intake, and one of the causes could be the precariousness of oral health. Several risk factors associated with deficient dietary protein intake have been identified, namely greater physical dependence, reduced caloric intake and food insecurity, but no studies have analysed whether tooth loss and prostheses interfere with protein intake...
December 7, 2017: Gerodontology
https://www.readbyqxmd.com/read/29214461/co-ingestion-of-protein-or-a-protein-hydrolysate-with-carbohydrate-enhances-anabolic-signaling-but-not-glycogen-resynthesis-following-recovery-from-prolonged-aerobic-exercise-in-trained-cyclists
#8
Karl E Cogan, Mark Evans, Enzo Iuliano, Audrey Melvin, Davide Susta, Karl Neff, Giuseppe De Vito, Brendan Egan
PURPOSE: The effect of carbohydrate (CHO), or CHO supplemented with either sodium caseinate protein (CHO-C) or a sodium caseinate protein hydrolysate (CHO-H) on the recovery of skeletal muscle glycogen and anabolic signaling following prolonged aerobic exercise was determined in trained male cyclists [n = 11, mean ± SEM age 28.8 ± 2.3 years; body mass (BM) 75.0 ± 2.3 kg; VO2peak 61.3 ± 1.6 ml kg-1 min-1]. METHODS: On three separate occasions, participants cycled for 2 h at ~ 70% VO2peak followed by a 4-h recovery period...
December 6, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29212859/human-hair-follicle-transcriptome-profiling-a-minimally-invasive-tool-to-assess-molecular-adaptations-upon-low-volume-high-intensity-interval-training
#9
Jing Zhang, Sarah J Wallace, Maria Y Shiu, Ingrid Smith, Shawn G Rhind, Valerie S Langlois
High-intensity interval training (HIIT) has become a popular fitness training approach under both civilian and military settings. Consisting of brief and intense exercise intervals, HIIT requires less time commitment yet is able to produce the consistent targeted physical adaptations as conventional endurance training. To effectively characterize and monitor HIIT-induced cellular and molecular responses, a highly accessible yet comprehensive biomarker discovery source is desirable. Both gene differential expression (DE) and gene set (GS) analyses were conducted using hair follicle transcriptome established from pre and postexercise subjects upon a 10-day HIIT program by RNA-Seq, Comparing between pre and posttraining groups, differentially expressed protein coding genes were identified...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29212609/effect-of-combined-exercise-versus-aerobic-only-training-on-skeletal-muscle-lipid-metabolism-in-a-rodent-model-of-type1-diabetes
#10
Michelle S Dotzert, Matthew W McDonald, Michael R Murray, J Zachary Nickels, Earl G Noble, C W James Melling
OBJECTIVES: Abnormal skeletal muscle lipid metabolism is associated with insulin resistance in people with type 1 diabetes. Although lipid metabolism is restored with aerobic exercise training, the risk for postexercise hypoglycemia is increased with this modality. Integrating resistance and aerobic exercise is associated with reduced hypoglycemic risk; however, the effects of this exercise modality on lipid metabolism and insulin resistance remain unknown. We compared the effects of combined (aerobic + resistance) versus aerobic exercise training on oxidative capacity and muscle lipid metabolism in a rat model of type 1 diabetes...
December 4, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29212021/nutritive-post-ingestive-signals-are-the-primary-regulators-of-agrp-neuron-activity
#11
Zhenwei Su, Amber L Alhadeff, J Nicholas Betley
The brain regulates food intake by processing sensory cues and peripheral physiological signals, but the neural basis of this integration remains unclear. Hypothalamic, agouti-related protein (AgRP)-expressing neurons are critical regulators of food intake. AgRP neuron activity is high during hunger and is rapidly reduced by the sight and smell of food. Here, we reveal two distinct components of AgRP neuron activity regulation: a rapid but transient sensory-driven signal and a slower, sustained calorie-dependent signal...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29212003/soce-is-important-for-maintaining-sarcoplasmic-calcium-content-and-release-in-skeletal-muscle-fibers
#12
Mónika Sztretye, Nikolett Geyer, János Vincze, Dána Al-Gaadi, Tamás Oláh, Péter Szentesi, Gréta Kis, Miklós Antal, Ildikó Balatoni, László Csernoch, Beatrix Dienes
Store-operated Ca2+ entry (SOCE) is a Ca2+-entry process activated by the depletion of intracellular stores and has an important role in many cell types. In skeletal muscle, however, its role during physiological muscle activation has been controversial. To address this question, sarcoplasmic reticulum (SR) calcium release in a mouse strain with a naturally occurring mutation in the myostatin gene (Compact (Cmpt)) leading to a hypermuscular yet reduced muscle-force phenotype was compared to that in wild-type mice...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29207246/multiple-reaction-monitoring-for-the-quantitation-of-serum-protein-glycosylation-profiles-application-to-ovarian-cancer
#13
Suzanne Miyamoto, Carol D Stroble, Sandra Taylor, Qiuting Hong, Carlito B Lebrilla, Gary S Leiserowitz, Kyoungmi Kim, L Renee Ruhaak
Protein glycosylation fingerprints are widely recognized as potential markers for disease states and indeed differential glycosylation has been identified in multiple types of autoimmune diseases and several types of cancer. However, releasing the glycans leave the glycoproteins unknown, therefore there exists a need for high-throughput methods that allow quantification of site- and protein- specific glycosylation patterns from complex biological mixtures. In this study, a targeted multiple reaction monitoring (MRM)-based method for the protein- and site- specific quantitation involving serum proteins immunoglobulins A, G and M, alpha-1-antitrypsin, transferrin, alpha-2-macroglobulin, haptoglobin, alpha-1-acid glycoprotein and complement C3 was developed...
December 5, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29203714/exercise-heat-shock-proteins-and-insulin-resistance
#14
REVIEW
Ashley E Archer, Alex T Von Schulze, Paige C Geiger
Best known as chaperones, heat shock proteins (HSPs) also have roles in cell signalling and regulation of metabolism. Rodent studies demonstrate that heat treatment, transgenic overexpression and pharmacological induction of HSP72 prevent high-fat diet-induced glucose intolerance and skeletal muscle insulin resistance. Overexpression of skeletal muscle HSP72 in mice has been shown to increase endurance running capacity nearly twofold and increase mitochondrial content by 50%. A positive correlation between HSP72 mRNA expression and mitochondrial enzyme activity has been observed in human skeletal muscle, and HSP72 expression is markedly decreased in skeletal muscle of insulin resistant and type 2 diabetic patients...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29202017/molecular-motor-dnm1-synergistically-induces-membrane-curvature-to-facilitate-mitochondrial-fission
#15
Michelle W Lee, Ernest Y Lee, Ghee Hwee Lai, Nolan W Kennedy, Ammon E Posey, Wujing Xian, Andrew L Ferguson, R Blake Hill, Gerard C L Wong
Dnm1 and Fis1 are prototypical proteins that regulate yeast mitochondrial morphology by controlling fission, the dysregulation of which can result in developmental disorders and neurodegenerative diseases in humans. Loss of Dnm1 blocks the formation of fission complexes and leads to elongated mitochondria in the form of interconnected networks, while overproduction of Dnm1 results in excessive mitochondrial fragmentation. In the current model, Dnm1 is essentially a GTP hydrolysis-driven molecular motor that self-assembles into ring-like oligomeric structures that encircle and pinch the outer mitochondrial membrane at sites of fission...
November 22, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29200983/the-short-term-effect-of-high-versus-moderate-protein-intake-on-recovery-after-strength-training-in-resistance-trained-individuals
#16
Justin Roberts, Anastasia Zinchenko, Craig Suckling, Lee Smith, James Johnstone, Menno Henselmans
Background: Dietary protein intakes up to 2.9 g.kg-1.d-1 and protein consumption before and after resistance training may enhance recovery, resulting in hypertrophy and strength gains. However, it remains unclear whether protein quantity or nutrient timing is central to positive adaptations. This study investigated the effect of total dietary protein content, whilst controlling for protein timing, on recovery in resistance trainees. Methods: Fourteen resistance-trained individuals underwent two 10-day isocaloric dietary regimes with a protein content of 1...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29200982/native-whey-protein-with-high-levels-of-leucine-results-in-similar-post-exercise-muscular-anabolic-responses-as-regular-whey-protein-a-randomized-controlled-trial
#17
Håvard Hamarsland, Anne Lene Nordengen, Sigve Nyvik Aas, Kristin Holte, Ina Garthe, Gøran Paulsen, Matthew Cotter, Elisabet Børsheim, Haakon B Benestad, Truls Raastad
Background: Protein intake is essential to maximally stimulate muscle protein synthesis, and the amino acid leucine seems to possess a superior effect on muscle protein synthesis compared to other amino acids. Native whey has higher leucine content and thus a potentially greater anabolic effect on muscle than regular whey (WPC-80). This study compared the acute anabolic effects of ingesting 2 × 20 g of native whey protein, WPC-80 or milk protein after a resistance exercise session...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29200906/effects-of-intermittent-ladder-climbing-exercise-training-on-mitochondrial-biogenesis-and-endoplasmic-reticulum-stress-of-the-cardiac-muscle-in-obese-middle-aged-rats
#18
Kijin Kim, Nayoung Ahn, Suryun Jung, Solee Park
The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200899/effects-of-exercise-on-obesity-induced-mitochondrial-dysfunction-in-skeletal-muscle
#19
REVIEW
Jun-Won Heo, Mi-Hyun No, Dong-Ho Park, Ju-Hee Kang, Dae Yun Seo, Jin Han, P Darrell Neufer, Hyo-Bum Kwak
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle. Mitochondria are dynamic organelles that regulate cellular metabolism and bioenergetics, including ATP production via oxidative phosphorylation. Due to these critical roles of mitochondria, mitochondrial dysfunction results in various diseases such as obesity and type 2 diabetes. Obesity is associated with impairment of mitochondrial function (e...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29200843/eosinophilic-and-non-eosinophilic-copd-patients-with-chronic-respiratory-failure-neutrophil-to-lymphocyte-ratio-as-an-exacerbation-marker
#20
Eylem Acartürk Tunçay, Zuhal Karakurt, Emine Aksoy, Cuneyt Saltürk, Sinem Gungor, Nezihe Ciftaslan, İlim Irmak, Dilek Yavuz, Birsen Ocakli, Nalan Adıgüzel
Aim: Increased dyspnea, sputum volume, and purulence are subjective symptoms in COPD patients. To diagnose COPD exacerbations with chronic respiratory failure (CRF) and to assess the requirement for antibiotic treatment, physicians require more objective criteria. We aimed to investigate whether neutrophil-to-lymphocyte ratio (NLR) can be used as an infectious exacerbation marker in COPD patients with CRF. Patients and methods: This retrospective cross-sectional study was performed in the intensive care outpatient clinic of a tertiary training hospital between 2014 and 2015...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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