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https://www.readbyqxmd.com/read/28231611/leg-vascular-and-skeletal-muscle-mitochondrial-adaptations-to-aerobic-high-intensity-exercise-training-are-enhanced-in-the-early-postmenopausal-phase
#1
Michael Nyberg, Jon Egelund, Camilla M Mandrup, Caroline B Andersen, Karen M B E Hansen, Ida-Marie F Hergel, Nicholai Valbak-Andersen, Ruth Frikke-Schmidt, Bente Stallknecht, Jens Bangsbo, Ylva Hellsten
Exercise training leads to favourable adaptations within skeletal muscle; however, this effect of exercise training may be blunted in postmenopausal women due to the loss of oestrogens. Furthermore, postmenopausal women may have an impaired vascular response to acute exercise. We examined the haemodynamic response to acute exercise in matched pre- and postmenopausal women before and after 12 weeks of aerobic high intensity exercise training. Twenty premenopausal and 16 early postmenopausal (3.1 ± 0.5 [mean ± SEM] years after final menstrual period) women only separated by 4 (50 ± 0 versus 54 ± 1) years of age were included...
February 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28229646/special-nutrition-intervention-is-required-for-muscle-protective-efficacy-of-physical-exercise-in-elderly-people-at-highest-risk-of-sarcopenia
#2
A Molnár, I Jónásné Sztruhár, Á A Csontos, Cs Ferencz, Sz Várbíró, B Székács
Progressive loss of muscle mass and strength is a physiological consequence of aging, and without interventions, it usually deteriorates into sarcopenia. In this study, the hypothesis that combined special nutritional-physiotherapeutical intervention to prevent or reverse this biological deterioration in elderly people was tested. The effects of the regular resistance muscle training (PT, n = 17) alone and the combined exercise + special nutrition therapy containing whey protein and vitamin D (PT + NT, n = 17) were monitored for 3 months in 34 elderly patients (12 men and 22 women; mean age: 66...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28229430/differences-in-biomarkers-of-cartilage-matrix-turnover-and-their-changes-over-2%C3%A2-years-in-adolescent-and-adult-volleyball-athletes
#3
Heide Boeth, Aoife MacMahon, A Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N Duda
BACKGROUND: This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. METHODS: Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28229255/nordic-walking-training-attenuation-of-oxidative-stress-in-association-with-a-drop-in-body-iron-stores-in-elderly-women
#4
Jakub Kortas, Agnieszka Kuchta, Krzysztof Prusik, Katarzyna Prusik, Ewa Ziemann, Sandra Labudda, Agnieszka Ćwiklińska, Ewa Wieczorek, Maciej Jankowski, Jedrzej Antosiewicz
Excess body iron accumulation and oxidative stress has been associated with ageing. Regular exercise has been shown to reduce oxidative stress and induce some changes in iron metabolism. However, the effects of exercise on both of these parameters have been poorly investigated. In our study, 35 elderly women participated in 12 weeks of Nordic walking (NW) training (three times a week). We demonstrated that the training caused a significant reduction in malondialdehyde advanced oxidation protein products-markers of oxidative stress but had no effects on paraoxonase 1 activity...
February 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28228285/mass-spectrometry-profiling-of-hla-associated-peptidomes-in-mono-allelic-cells-enables-more-accurate-epitope-prediction
#5
Jennifer G Abelin, Derin B Keskin, Siranush Sarkizova, Christina R Hartigan, Wandi Zhang, John Sidney, Jonathan Stevens, William Lane, Guang Lan Zhang, Thomas M Eisenhaure, Karl R Clauser, Nir Hacohen, Michael S Rooney, Steven A Carr, Catherine J Wu
Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules underlying antigen presentation. However, a key obstacle is the ambiguity that arises from the co-expression of multiple HLA alleles. Here, we have implemented a scalable mono-allelic strategy for profiling the HLA peptidome. By using cell lines expressing a single HLA allele, optimizing immunopurifications, and developing an application-specific spectral search algorithm, we identified thousands of peptides bound to 16 different HLA class I alleles...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28225828/systematic-analysis-of-non-structural-protein-features-for-the-prediction-of-ptm-function-potential-by-artificial-neural-networks
#6
Henry M Dewhurst, Matthew P Torres
Post-translational modifications (PTMs) provide an extensible framework for regulation of protein behavior beyond the diversity represented within the genome alone. While the rate of identification of PTMs has rapidly increased in recent years, our knowledge of PTM functionality encompasses less than 5% of this data. We previously developed SAPH-ire (Structural Analysis of PTM Hotspots) for the prioritization of eukaryotic PTMs based on function potential of discrete modified alignment positions (MAPs) in a set of 8 protein families...
2017: PloS One
https://www.readbyqxmd.com/read/28225479/long-lasting-training-in-the-barnes-maze-prompts-hippocampal-spinogenesis-and-habituation-in-rats
#7
Maia Uriarte, Olalekan M Ogundele, Joaquin Pardo
There is a constant need to assess spatial memory in small rodents to elucidate the basics of cognition in neuroscience experiments. Thus, the significance of the Barnes maze in the biology of hippocampal and cortical neural function cannot be overemphasized. Despite the wide use of the Barnes maze, the effect of maze task training on the structure of hippocampal neurons is yet to be elucidated. Adult Sprague-Dawley rats were subjected to intense training on the Barnes maze (3 months). Subsequently, the hippocampus (cornus ammonis and dentate gyrus) of separate sets of rats was processed for Golgi Colonnier techniques (silver impregnation) and adenoviral-green fluorescent protein labeling (immunohistochemistry)...
February 20, 2017: Neuroreport
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#8
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28224488/hmms-in-protein-fold-classification
#9
Christos Lampros, Costas Papaloukas, Themis Exarchos, Dimitrios I Fotiadis
The limitation of most HMMs is their inherent high dimensionality. Therefore we developed several variations of low complexity models that can be applied even to protein families with a few members. In this chapter we present these variations. All of them include the use of a hidden Markov model (HMM), with a small number of states (called reduced state-space HMM), which is trained with both amino acid sequence and secondary structure of proteins whose 3D structure is known and it is used for protein fold classification...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28223068/parasite-control-and-skeletal-myositis-in-trypanosoma-cruzi-infected-and-exercised-rats
#10
Rômulo D Novaes, Reggiani V Gonçalves, Arlete R Penitente, Marli C Cupertino, Izabel R S C Maldonado, André Talvani, Antônio J Natali
Non-pharmacological strategies have been rarely described in the treatment of infectious diseases. Although exercise training has been recently incorporated in the clinical management of Chagas disease, the rationale basis that supports this indication is poorly understood. Thus, we investigated the effect of an aerobic exercise on the parasitism, inflammation and oxidative tissue damage in a murine model of Trypanosoma cruzi-induced skeletal myositis. Wistar rats were randomized into four groups: trained not infected (TNI) and infected (TI), sedentary not infected (SNI) and infected (SI)...
February 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28221002/computational-biology-and-chemistry-in-mti-emphasis-on-the-prediction-of-some-admet-properties
#11
REVIEW
Maria A Miteva, Bruno O Villoutreix
Our research and teaching group called MTi (Molécules Thérapeutiques in silico) has developed numerous applications available online, thanks to the RPBS platform (Ressource Parisienne en Bioinformatique Structurale), in the field of chemoinformatics, structural bioinformatics and drug design. Since its opening in 2009, over 200 articles/reviews have been reported and involve virtual screening studies, prediction of druggability, analysis of protein-protein interaction inhibitors, development of databases, data mining and knowledge discovery, as well as combined in silico-in vitro work to search for new hits and chemical probes acting on original targets in several therapeutic areas...
February 21, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28215847/prostate-cancer-screening-in-men-aged-50-to-69-years-sthlm3-a-prospective-population-based-diagnostic-study-gr%C3%A3-nberg-h-adolfsson-j-aly-m-nordstr%C3%A3-m-t-wiklund-p-brandberg-y-thompson-j-wiklund-f-lindberg-j-clements-m-egevad-l-eklund-m-lancet-oncol-2015-dec-16
#12
Eggener Scott, J Adolfsson, M Aly, T Nordström, P Wiklund, Y Brandberg, J Thompson, F Wiklund, J Lindberg, M Clements, L Egevad, M Eklund
BACKGROUND: The prostate-specific antigen (PSA) test is used to screen for prostate cancer but has a high false-positive rate that translates into unnecessary prostate biopsies and overdiagnosis of low-risk prostate cancers. We aimed to develop and validate a model to identify high-risk prostate cancer (with a Gleason score of at least 7) with better test characteristics than that provided by PSA screening alone. METHODS: The Stockholm 3 (STHLM3) study is a prospective, population-based, paired, screen-positive, diagnostic study of men without prostate cancer aged 50 to 69 years randomly invited by date of birth from the Swedish Population Register kept by the Swedish Tax Agency...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28215314/the-reduced-oxidized-state-of-plasma-albumin-is-modulated-by-dietary-protein-intake-partly-via-albumin-synthesis-rate-in-rats
#13
Yasuaki Wada, Yoshiyasu Sato, Keisuke Miyazaki, Yasuhiro Takeda, Masashi Kuwahata
The reduced/oxidized state of plasma albumin is influenced by many factors, including chronic diseases and strenuous training. Recently, the reduced/oxidized state has also been shown to be associated with dietary protein and energy intakes in rats. We hypothesized that dietary protein intake may modulate the reduced/oxidized state of plasma albumin by altering the rate of albumin synthesis and that the reduced/oxidized state could therefore serve as a novel marker of protein undernutrition. We tested this hypothesis by examining male growing rats placed on a low-protein or energy-restriction diet...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28214588/the-experiences-of-a-biochemist-in-the-evolving-world-of-g-protein-dependent-signaling
#14
REVIEW
Richard A Cerione
This review describes how a biochemist and basic researcher (i.e. myself) came to make a career in the area of receptor-coupled signal transduction and the roles cellular signaling activities play both in normal physiology and in disease. Much of what has been the best part of this research life is due to the time I spent with Bob Lefkowitz (1982-1985), during an extraordinary period in the emerging field of G-protein-coupled receptors. Among my laboratory colleagues were some truly outstanding scientists including Marc Caron, the late Jeffrey Stadel, Berta Strulovici, Jeff Benovic, Brian Kobilka, and Henrik Dohlman, as well as many more...
February 15, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28212449/energy-intake-and-energy-expenditure-of-pre-professional-female-contemporary-dancers
#15
Meghan A Brown, Glyn Howatson, Edel Quin, Emma Redding, Emma J Stevenson
Many athletes in aesthetic and weight dependent sports are at risk of energy imbalance. However little is known about the exercise and eating behaviours of highly trained dance populations. This investigation sought to determine the energy intake and energy expenditure of pre-professional female contemporary dancers. Twenty-five female contemporary dance students completed the study. Over a 7-day period, including five week days (with scheduled dance training at a conservatoire) and two weekend days (with no scheduled dance training at the conservatoire), energy intake (self-reported weighed food diary and 24 h dietary recall) and expenditure (tri-axial accelerometry) were recorded...
2017: PloS One
https://www.readbyqxmd.com/read/28211481/effects-of-strength-training-on-osteogenic-differentiation-and-bone-strength-in-aging-female-wistar-rats
#16
Monique Patricio Singulani, Camila Tami Stringhetta-Garcia, Leandro Figueiredo Santos, Samuel Rodrigues Lourenço Morais, Mário Jefferson Quirino Louzada, Sandra Helena Penha Oliveira, Antonio Hernandes Chaves Neto, Rita Cássia Menegati Dornelles
The effects of strength training (ST) on the mechanical bone strength and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) from adult, aged and exercised aged rats were determined. The exercised aged animals displayed higher values of areal bone mineral density, compression test, alkaline phosphatase activity (ALP) and biological mineralization, while oil red O staining for adipocytes was lower. ST increased gene expression of runt-related transcription factor 2 (Runx2), osterix (Osx) as well as bone matrix protein expression, and reduced expression of peroxisome proliferator-activated receptor gamma (Pparγ)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208581/macronutrient-intakes-in-553-dutch-elite-and-sub-elite-endurance-team-and-strength-athletes-does-intake-differ-between-sport-disciplines
#17
Floris Wardenaar, Naomi Brinkmans, Ingrid Ceelen, Bo Van Rooij, Marco Mensink, Renger Witkamp, Jeanne De Vries
Web-based 24-h dietary recalls and questionnaires were obtained from 553 Dutch well-trained athletes. The total energy and macronutrient intake was compared between discipline-categories (endurance, team, and strength) within gender, and dietary inadequacy, i.e., too low or high intakes, according to selected recommendations and guidelines, was evaluated by applying a probability approach. On average, 2.83 days per person were reported with a mean energy intake of 2566-2985 kcal and 1997-2457 kcal per day, for men and women, respectively...
February 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28207880/skeletal-muscle-metabolic-adaptations-to-endurance-exercise-training-are-attainable-in-mice-with-simvastatin-treatment
#18
William M Southern, Anna S Nichenko, Daniel D Shill, Corey C Spencer, Nathan T Jenkins, Kevin K McCully, Jarrod A Call
We tested the hypothesis that a 6-week regimen of simvastatin would attenuate skeletal muscle adaptation to low-intensity exercise. Male C57BL/6J wildtype mice were subjected to 6-weeks of voluntary wheel running or normal cage activities with or without simvastatin treatment (20 mg/kg/d, n = 7-8 per group). Adaptations in in vivo fatigue resistance were determined by a treadmill running test, and by ankle plantarflexor contractile assessment. The tibialis anterior, gastrocnemius, and plantaris muscles were evaluated for exercised-induced mitochondrial adaptations (i...
2017: PloS One
https://www.readbyqxmd.com/read/28205605/the-role-of-the-rna-demethylase-fto-fat-mass-and-obesity-associated-and-mrna-methylation-in-hippocampal-memory-formation
#19
Brandon J Walters, Valentina Mercaldo, Colleen J Gillon, Matthew Yip, Rachael L Neve, Frederick M Boyce, Paul W Frankland, Sheena A Josselyn
The formation of long-lasting memories requires coordinated changes in gene expression and protein synthesis (Davis and Squire, 1984; Duvarci et al, 2008; Hernandez and Abel, 2008). Although many studies implicate DNA modifications (DNA methylation, histone modifications) in memory formation, the contributions of RNA modifications remain largely unexplored. Here, we investigated the role of mRNA methylation in hippocampal-dependent memory formation in mice. RNA modifications are highly dynamic and readily reversible (Jia et al, 2013)...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28202615/il-13-mediated-regulation-of-learning-and-memory
#20
Tiroyaone M Brombacher, Justin K Nono, Keisha S De Gouveia, Nokuthula Makena, Matthew Darby, Jacqueline Womersley, Ousman Tamgue, Frank Brombacher
The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the cytokine. More recently, the type 2 IL-4 has been demonstrated to play a role in cognition. In this study, using the Morris water maze task, we demonstrate that IL-13-deficient mice are significantly impaired in working memory as well as attenuated reference memory, both functions essential for effective complex learning. During the learning process, wild-type mice increased the number of CD4(+) T cells in the meninges and production of IL-13, whereas neither Morris water maze-trained IL-4 nor trained IL-13-deficient mice were able to increase CD4(+) T cells in the meninges...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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