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https://www.readbyqxmd.com/read/29049322/pgc-1%C3%AE-and-exercise-intensity-dependent-adaptations-in-mouse-skeletal-muscle
#1
Nina Brandt, Maja Munk Dethlefsen, Jens Bangsbo, Henriette Pilegaard
The aim of the present study was to examine the role of PGC-1α in intensity dependent exercise and exercise training-induced metabolic adaptations in mouse skeletal muscle. Whole body PGC-1α knockout (KO) and littermate wildtype (WT) mice performed a single treadmill running bout at either low intensity (LI) for 40 min or moderate intensity (MI) for 20 min. Blood and quadriceps muscles were removed either immediately after exercise or at 3h or 6h into recovery from exercise and from resting controls. In addition PGC-1α KO and littermate WT mice were exercise trained at either low intensity (LIT) for 40 min or at moderate intensity (MIT) for 20 min 2 times pr...
2017: PloS One
https://www.readbyqxmd.com/read/29049000/oral-nutrition-as-a-form-of-pre-operative-enhancement-in-patients-undergoing-surgery-for-colorectal-cancer-a-systematic-review
#2
Emma R J Bruns, Tanja E Argillander, Baukje Van Den Heuvel, Christianne J Buskens, Peter Van Duijvendijk, Renate M Winkels, Annette Kalf, Edwin S Van Der Zaag, Eelco B Wassenaar, Willem A Bemelman, Barbara C Van Munster
BACKGROUND: Nutritional status has major impacts on the outcome of surgery, in particular in patients with cancer. The aim of this review was to assess the merit of oral pre-operative nutritional support as a part of prehabilitation in patients undergoing surgery for colorectal cancer. METHODS: A systematic literature search and meta-analysis was performed according to the Preferred Reporting of Systematic Reviews and Meta-Analyses (PRISMA) recommendations in order to review all trials investigating the effect of oral pre-operative nutritional support in patients undergoing colorectal surgery...
October 19, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29047334/a-support-vector-machine-based-method-to-distinguish-long-non-coding-rnas-from-protein-coding-transcripts
#3
Hugo W Schneider, Taina Raiol, Marcelo M Brigido, Maria Emilia M T Walter, Peter F Stadler
BACKGROUND: In recent years, a rapidly increasing number of RNA transcripts has been generated by thousands of sequencing projects around the world, creating enormous volumes of transcript data to be analyzed. An important problem to be addressed when analyzing this data is distinguishing between long non-coding RNAs (lncRNAs) and protein coding transcripts (PCTs). Thus, we present a Support Vector Machine (SVM) based method to distinguish lncRNAs from PCTs, using features based on frequencies of nucleotide patterns and ORF lengths, in transcripts...
October 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29044963/using-sds-page-gel-finger-printing-to-identify-soft-bodied-wood-boring-insect-larvae-to-species
#4
Mark A O'Neill, Mia Denos, Daniel Reed
BACKGROUND: This paper describes the progress which we have made assessing the feasibility of "finger printing" using imaged SDS-PAGE gels of haemolymph proteins, to identify soft bodied wood boring insect larvae such as the Asian longhorn beetle, Anoplophora glabripennis (Motscholsky, 1853) (Coleoptera: Cerambycidae). Due to stringent import restrictions and difficulty in obtaining licences to work with these organisms, we opted to work with four species of scarab beetle, Mecynorhina polyphemus (Fabricius, 1781), Pachnoda sinuata (Fabricius ,1775), Eucidella shiratica (Csiki, 1909) and Eucidella shultzeorum (Kolbe, 1906) which have near identical larval morphologies...
October 17, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29043432/recent-advances-in-pharmacological-hormonal-and-nutritional-intervention-for-sarcopenia
#5
REVIEW
Kunihiro Sakuma, Akihiko Yamaguchi
Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and often frailty. This review focuses on the recent advances of pharmacological, hormonal, and nutritional approaches for attenuating sarcopenia. The article is composed of the data reported in many basic and some clinical studies for mammalian muscles. Resistance training combined with amino acid-containing supplements is the gold standard to prevent sarcopenia...
October 18, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29043222/production-of-fermented-kale-juices-with-lactobacillus-strains-and-nutritional-composition
#6
Seong Yeong Kim
Fermented kale juices using four types of lactobacilli were produced in the present study. After 48 h of fermentation time, viable cell counts of all ferments reached an above 10(9) CFU/mL. The viability of the ferments after cold storage in the refrigerator for 4 weeks showed 10(8) CFU/mL in all ferments. Among four types of fermented kale juices, the ferment of Lactobacillus acidophilus IFO 3025 indicated a good nutritional composition, including neutral sugar (1,909.76 μg/mL), reducing sugar (564.00 μg/mL, P<0...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042212/morfpred-plus-computational-identification-of-morfs-in-protein-sequences-using-physicochemical-properties-and-hmm-profiles
#7
Ronesh Sharma, Maitsetseg Bayarjargal, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma
Motivation Intrinsically Disordered Proteins (IDPs) lack stable tertiary structure and they actively participate in performing various biological functions. These IDPs expose short binding regions called Molecular Recognition Features (MoRFs) that permit interaction with structured protein regions. Upon interaction they undergo a disorder-to-order transition as a result of which their functionality arises. Predicting these MoRFs in disordered protein sequences is a challenging task. Method In this study, we present MoRFpred-plus, an improved predictor over our previous proposed predictor to identify MoRFs in disordered protein sequences...
October 14, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29040226/propranolol-and-oxandrolone-therapy-accelerated-muscle-recovery-in-burned-children
#8
Tony Chao, Craig Porter, David N Herndon, Aikaterina Siopi, Henry Ideker, Ronald P Mlcak, Labros S Sidossis, Oscar E Suman
INTRODUCTION: Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogues showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness and protein turnover are unknown...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29039790/prolango-protein-function-prediction-using-neural-machine-translation-based-on-a-recurrent-neural-network
#9
Renzhi Cao, Colton Freitas, Leong Chan, Miao Sun, Haiqing Jiang, Zhangxin Chen
With the development of next generation sequencing techniques, it is fast and cheap to determine protein sequences but relatively slow and expensive to extract useful information from protein sequences because of limitations of traditional biological experimental techniques. Protein function prediction has been a long standing challenge to fill the gap between the huge amount of protein sequences and the known function. In this paper, we propose a novel method to convert the protein function problem into a language translation problem by the new proposed protein sequence language "ProLan" to the protein function language "GOLan", and build a neural machine translation model based on recurrent neural networks to translate "ProLan" language to "GOLan" language...
October 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29038420/effects-of-different-training-loads-on-emotional-state-and-mrna-and-protein-expressions-of-n-methyl-d-aspartate-receptor-subunits-postsynaptic-density-95-and-kinesin-family-member-17-in-hippocampus-of-rats
#10
Hefei Ren, Xinyi Yu, Liren Yu, Yinguo Zhang, Hong Xie, Na Shi, Lijun Chen
BACKGROUND Emotional state can be affected by different training loads. The aim of this study was to explore the changes of rat emotional state, as well as the mRNA and protein expressions of N-methyl-D-aspartate receptors (NMDARs), postsynaptic density 95 (PSD-95), and kinesin family member 17 (KIF-17) in the hippocampus, by long-term moderate-intensity and high-intensity training models in rats. MATERIAL AND METHODS The exercise model of SD rats was set up by treadmill running of moderate and high intensities for 4 weeks...
October 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29038365/muscle-ion-transporters-and-antioxidative-proteins-have-different-adaptive-potential-in-arm-than-in-leg-skeletal-muscle-with-exercise-training
#11
Magni Mohr, Tobias Schmidt Nielsen, Pál Weihe, Jákup A Thomsen, Giovanna Aquino, Peter Krustrup, Nikolai B Nordsborg
It was evaluated whether upper-body compared to lower-body musculature exhibits a different phenotype in relation to capacity for handling reactive oxygen species (ROS), H(+), La(-), Na(+), K(+) and also whether it differs in adaptive potential to exercise training. Eighty-three sedentary premenopausal women aged 45 ± 6 years (mean ± SD) were randomized into a high-intensity intermittent swimming group (HIS, n = 21), a moderate-intensity swimming group (MOS, n = 21), a soccer group (SOC, n = 21), or a control group (CON, n = 20)...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29038363/moderate-exercise-training-does-not-prevent-the-reduction-in-myocardial-l-type-ca-2-channels-protein-expression-at-obese-rats
#12
Vitor L da Silva, Ana P Lima-Leopoldo, Artur J T Ferron, Jóctan P Cordeiro, Paula P Freire, Dijon H S de Campos, Carlos R Padovani, Mário M Sugizaki, Antonio C Cicogna, André S Leopoldo
Authors have showed that obesity implicates cardiac dysfunction associated with myocardial L-type calcium channels (LTCCs) activity impairments, as well as moderate exercise training (MET) seems to be an important therapeutic tool. We tested the hypothesis that MET promotes improvements on LTCCS activity and protein expression at obesity induced by unsaturated high-fat diets, which could represent a protective effects against development of cardiovascular damage. Male Wistar rats were randomized in control (C, n = 40), which received a standard diet and obese (Ob; n = 40), which received high-fat diet...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29038242/activity-dependent-facilitation-of-cav1-3-calcium-channels-promotes-kca3-1-activation-in-hippocampal-neurons
#13
Giriraj Sahu, Hadhimulya Asmara, Fang-Xiong Zhang, Gerald W Zamponi, Ray W Turner
CaV1 L-type calcium channels are key to regulating neuronal excitability, with the range of functional roles enhanced by interactions with calmodulin, accessory proteins, or CaMKII that modulate channel activity. In hippocampal pyramidal cells a prominent elevation of CaV1 activity is apparent in late channel openings that can last for seconds following a depolarizing stimulus train. The current study tested the hypothesis that a reported interaction between CaV1.3 channels, the scaffolding protein densin, and CaMKII could generate a facilitation of channel activity that outlasts a depolarizing stimulus...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29036762/low-intensity-aerobic-exercise-training-inhibition-of-skeletal-muscle-atrophy-in-high-fat-diet-induced-ovariectomized-rats
#14
Hye Jin Kim, Won Jun Lee
PURPOSE: Postmenopausal women are highly susceptible to diseases, such as obesity, type 2 diabetes, osteoporosis, or skeletal muscle atrophy and many people recognize the need for regular physical activity. Aerobic exercise training is known to improve the oxidative capacity and insulin sensitivity of skeletal muscles. This study aimed to investigate the role of low-intensity aerobic exercise training on skeletal muscle protein degradation or synthesis in the plantaris muscles of high-fat-fed ovariectomized rats...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29036761/effects-of-conjugated-linoleic-acid-n-3-and-resistance-training-on-muscle-quality-and-expression-of-atrophy-related-ubiquitin-ligases-in-middle-aged-mice-with-high-fat-dietinduced-obesity
#15
Seung-Lyul Oh, Sang-Rok Lee, Jeong-Su Kim
PURPOSE: To investigate the effects of conjugated linoleic acid (CLA)/n-3 supplements and resistance exercise training (RT) for 20 weeks on muscle quality and genes related to protein synthesis/degradation in middle-aged mice with high-fat diet (HFD)-induced obesity. METHODS: Nine-month-old C57BL/6 male mice were randomly assigned to five groups: 1) normal diet (C), 2) high-fat diet (H), 3) H+RT (HRT), 4) H+CLA/n-3 (H-CN), and 5) H+RT+CLA/n-3 (H-RTCN). HFD groups were given a diet containing 60% fat for 20 weeks, and exercised groups underwent progressive RT using weighted ladder climbing...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29036616/deeploc-prediction-of-protein-subcellular-localization-using-deep-learning
#16
José Juan Almagro Armenteros, Casper Kaae Sønderby, Søren Kaae Sønderby, Henrik Nielsen, Ole Winther
Motivation: The prediction of eukaryotic protein subcellular localization is a well-studied topic in bioinformatics due to its relevance in proteomics research. Many machine learning methods have been successfully applied in this task, but in most of them, predictions rely on annotation of homologues from knowledge databases. For novel proteins where no annotated homologues exist, and for predicting the effects of sequence variants, it is desirable to have methods for predicting protein properties from sequence information only...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29032504/resistance-exercise-improves-cardiac-function-and-mitochondrial-efficiency-in-diabetic-rat-hearts
#17
Tae Hee Ko, Jubert C Marquez, Hyoung Kyu Kim, Seung Hun Jeong, SungRyul Lee, Jae Boum Youm, In Sung Song, Dae Yun Seo, Hye Jin Kim, Du Nam Won, Kyoung Im Cho, Mun Gi Choi, Byoung Doo Rhee, Kyung Soo Ko, Nari Kim, Jong Chul Won, Jin Han
Metabolic disturbance and mitochondrial dysfunction are a hallmark of diabetic cardiomyopathy (DC). Resistance exercise (RE) not only enhances the condition of healthy individuals but could also improve the status of those with disease. However, the beneficial effects of RE in the prevention of DC and mitochondrial dysfunction are uncertain. Therefore, this study investigated whether RE attenuates DC by improving mitochondrial function using an in vivo rat model of diabetes. Fourteen Otsuka Long-Evans Tokushima Fatty rats were assigned to sedentary control (SC, n = 7) and RE (n = 7) groups at 28 weeks of age...
October 14, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29032392/exercise-and-gastrointestinal-symptoms-running-induced-changes-in-intestinal-permeability-and-markers-of-gastrointestinal-function-in-asymptomatic-and-symptomatic-runners
#18
Elisa Karhu, Richard A Forsgård, Lauri Alanko, Henrik Alfthan, Pirkko Pussinen, Esa Hämäläinen, Riitta Korpela
PURPOSE: Athletes frequently experience gastrointestinal (GI) symptoms during training and competition. Although the prevalence of exercise-induced GI symptoms is high, the mechanisms leading to GI distress during exercise are not fully understood. The aim of this study was to identify running-induced changes in intestinal permeability and markers of GI function and investigate their association with gastrointestinal symptoms. METHODS: We recruited 17 active runners who we allocated as either asymptomatic or symptomatic based on their history of experiencing GI symptoms during running...
October 14, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29032233/proteome-wide-prediction-and-annotation-of-mitochondrial-and-sub-mitochondrial-proteins-by-incorporating-domain-information
#19
Ravindra Kumar, Bandana Kumari, Manish Kumar
Mitochondrion is one of the most important subcellular organelle of eukaryotic cells. It carries out several biochemical functions that are extremely vital for cells. Defects in mitochondria also play an important role in the development and progression of different types of cancer. Therefore knowledge of complete mitochondrial protein repertoire is essential to understand overall mitochondrial functionality, maintenance, dynamics and metabolism. It would be of a great practical significance to develop an automated and reliable approach that can identify the mitochondrial proteins and their sub-mitochondrial location...
October 11, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29031957/exercise-training-attenuates-experimental-autoimmune-encephalomyelitis-by-peripheral-immunomodulation-rather-than-direct-neuroprotection
#20
Ofira Einstein, Nina Fainstein, Olga Touloumi, Roza Lagoudaki, Ester Hanya, Nikolaos Grigoriadis, Abram Katz, Tamir Ben-Hur
BACKGROUND: Conflicting results exist on the effects of exercise training (ET) on Experimental Autoimmune Encephalomyelitis (EAE), nor is it known how exercise impacts on disease progression. OBJECTIVE: We examined whether ET ameliorates the development of EAE by modulating the systemic immune system or exerting direct neuroprotective effects on the CNS. METHODS: Healthy mice were subjected to 6weeks of motorized treadmill running. The Proteolipid protein (PLP)-induced transfer EAE model in mice was utilized...
October 11, 2017: Experimental Neurology
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