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National Health insurance research database

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https://www.readbyqxmd.com/read/29164302/impact-of-initial-myocardial-perfusion-imaging-versus-invasive-coronary-angiography-on-outcomes-in-coronary-artery-disease-a-nationwide-cohort-study
#1
Guang-Uei Hung, Kuan-Yin Ko, Cheng-Li Lin, Ruoh-Fang Yen, Chia-Hung Kao
PURPOSE: In patients with stable coronary artery disease (CAD), two main options exist to guide management: initial invasive coronary angiography (CAG), or selective CAG after risk stratification using myocardial perfusion imaging (MPI). This study compared clinical outcomes between these two strategies in a large, real-world population. METHODS: The initial cohort comprised 1,000,000 randomly selected patients who had been entered in the National Health Insurance Research Database of Taiwan between 2000 and 2011...
November 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29163845/improved-medical-expenditure-and-survival-with-integration-of-traditional-chinese-medicine-treatment-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#2
Ming-Yen Tsai, Wen-Long Hu, Jen-Huai Chiang, Yu-Chuen Huang, Shih-Yu Chen, Yu-Chiang Hung, Yung-Hsiang Chen
Background: No previous studies have evaluated the effects of traditional Chinese medicine (TCM) treatment on patients with heart failure (HF). Hence, in this study, we determined whether TCM treatment affects the healthcare burden and survival of HF patients. Methods: Samples were retrieved from the registry of catastrophic illness patients of the Taiwan National Health Insurance Research Database (NHIRD). Based on a frequency (1:1) matched case-control design, patients with HF between 2000 and 2010 were designated as cases (TCM users) and controls (non-TCM users)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29158990/increased-risk-of-periodontitis-in-patients-with-psoriatic-disease-a-nationwide-population-based-retrospective-cohort-study
#3
Ni-Yu Su, Jing-Yang Huang, Chien-Jen Hu, Hui-Chieh Yu, Yu-Chao Chang
Aims: Periodontitis and psoriatic disease, including psoriasis (PS) and psoriatic arthritis (PsA), share the common risk factors and co-morbidities. However, the risk of periodontitis in patients with psoriatic disease still needs further investigation. This study was a nationwide population-based retrospective cohort study assessing the risk of periodontitis from psoriatic disease exposure. Materials and Methods: Patients with newly diagnosed psoriatic disease from 2003 to 2012 were identified from the Taiwanese National Health Insurance Research Database...
2017: PeerJ
https://www.readbyqxmd.com/read/29157231/risk-factors-for-contralateral-inguinal-hernia-repair-after-unilateral-inguinal-hernia-repair-in-male-adult-patients-analysis-from-a-nationwide-population-based-cohort-study
#4
Cheng-Hung Lee, Yu-Ting Chiu, Chi-Fu Cheng, Jin-Chia Wu, Wen-Yao Yin, Jian-Han Chen
BACKGROUND: To identify the rate of and risk factors for contralateral inguinal hernia (CIH) after unilateral inguinal hernia repair in adult male patients. METHODS: This retrospective cohort study identified from the Taiwan National Health Insurance Research Database (NHIRD). Information on all adult patients who underwent primary unilateral inguinal hernia repair without any other operation was collected using ICD-9 diagnostic and procedure codes. The exclusion criteria were laparoscopic hernia repair, non-primary repair, complicated hernia, other combined procedures, female and undetermined gender...
November 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29149339/human-immunodeficiency-virus-infection-increases-the-risk-of-incident-autoimmune-hemolytic-anemia-a-population-based-cohort-study-in-taiwan
#5
Yung-Feng Yen, Yu-Ching Lan, Chun-Teng Huang, I-An Jen, Marcelo Chen, Chun-Yuan Lee, Pei-Hung Chuang, Yun Lee, Donalde E Morisky, Yi-Ming Arthur Chen
Background: Currently, the association between human immunodeficiency virus (HIV) infection and subsequent development of autoimmune hemolytic anemia (AIHA) remains unclear. This nationwide population-based cohort study aimed to determine the association between incident AIHA and HIV infection in Taiwan. Methods: During 2000-2012, we identified people aged ≧15 years living with HIV (PLWH) from the Taiwan Centers for Disease Control HIV Surveillance System. Individuals were considered to be infected with HIV on the basis of positive results of an HIV type 1 Western blot...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29146610/association-between-stroke-risk-and-metformin-use-in-hemodialysis-patients-with-diabetes-mellitus-a-nested-case-control-study
#6
Li-Nien Chien, Chu-Lin Chou, His-Hsien Chen, Chih-Chin Kao, Yen-Chung Lin, Yueh-Lin Wu, Jin-Shuen Chen, Li-Ying Chen, Te-Chao Fang
BACKGROUND: Metformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. METHODS AND RESULTS: Using the National Health Insurance Research Database, we identified 17 760 patients with DM and new-onset hemodialysis between 2001 and 2013. Of these, 1898 patients hospitalized for either ischemic or hemorrhagic stroke were matched to 7592 control patients according to sex, age, and year of initial hemodialysis therapy by using incidence sampling...
November 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29142967/association-of-nonsteroidal-anti-inflammatory-drug-use-with-stroke-among-dialysis-patients
#7
Chih-Cheng Hsu, Yu-Kang Chang, Yueh-Han Hsu, Yu-Ru Lo, Jia-Sin Liu, Chao A Hsiung, Hui-Ju Tsai
Introduction: Limited studies have evaluated risk of stroke associated with the use of NSAIDs in patients with end-stage kidney disease. We examined the adverse effects of selective and nonselective NSAID use on the risk of stroke in dialysis patients. Methods: A case-crossover study was conducted using medical claims data from the National Health Insurance Research Database in Taiwan. We identified patients with ischemic and hemorrhagic stroke (defined as International Classification of Diseases, 9th revision, Clinical Modification codes 433, 434, and 436 for ischemic stroke and 430 and 431 for hemorrhagic stroke) from inpatient claims during the period from 2003 to 2012...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142034/cumulative-burden-of-glucocorticoid-related-adverse-events-in-patients-with-systemic-lupus-erythematosus-findings-from-a-12-year-longitudinal-study
#8
Hung-Lin Chen, Li-Jiuan Shen, Ping-Ning Hsu, Chieh-Yu Shen, Susan A Hall, Fei-Yuan Hsiao
OBJECTIVE: The aim of this population-based study is to examine the adverse events (AE) associated with longitudinal systemic glucocorticoid (GC) use among an ethnic Chinese systemic lupus erythematosus (SLE) cohort. METHODS: Our study subjects were patients with newly diagnosed SLE aged 18 and older who received at least 1 prescription of systemic GC between 2001 and 2012 from Taiwan's National Health Insurance Research Database (NHIRD). The earliest prescription date of systemic GC for each subject was defined as the index date...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29141875/cognitive-enhancers-associated-with-decreased-risk-of-injury-in-patients-with-dementia-a-nationwide-cohort-study-in-taiwan
#9
Pei-Chun Chao, Wu-Chien Chien, Chi-Hsiang Chung, Ching-Wen Chu, Chin-Bin Yeh, San-Yuan Huang, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Nian-Sheng Tzeng
This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients ≥age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000-2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification...
November 14, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29138876/lower-risk-of-dementia-with-pioglitazone-compared-with-other-second-line-treatments-in-metformin-based-dual-therapy-a-population-based-longitudinal-study
#10
Chieh-Hsiang Lu, Chen-Yi Yang, Chung-Yi Li, Cheng-Yang Hsieh, Huang-Tz Ou
AIMS/HYPOTHESIS: The effect of pioglitazone was compared with that of other second-line glucose-lowering drugs on the risk of dementia among individuals with type 2 diabetes receiving metformin-based dual therapy. METHODS: A total of 204,323 individuals with type 2 diabetes aged ≥18 years who were stable metformin users and dementia-free before the initiation of second-line glucose-lowering medication were identified in the period 2000-2011 from Taiwan's National Health Insurance Research Database and followed to the end of 2013...
November 14, 2017: Diabetologia
https://www.readbyqxmd.com/read/29137042/associations-among-medication-regimen-complexity-medical-specialty-and-medication-possession-ratio-in-newly-diagnosed-hypertensive-patients-a-population-based-study
#11
Chen-Pei Ho, Jih-I Yeh, Shu-Hui Wen, Tony Jer-Fu Lee
The aim of this study was to explore the associations among the medication regimen complexity index (MRCI), medical specialty, and medication possession ratio (MPR) in newly diagnosed hypertensive patients.Data from 19,859 newly diagnosed hypertensive patients were collected from 2,000,000 random samples of the National Health Insurance Research Database in Taiwan. All study participants were followed for 1 year after the first diagnosis of hypertension. MPR was defined as total days of antihypertensive drugs supplied/365 days...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136662/protective-effect-of-metformin-against-retinal-vein-occlusions-in-diabetes-mellitus-a-nationwide-population-based-study
#12
Tai-Chi Lin, De-Kuang Hwang, Chih-Chien Hsu, Chi-Hsien Peng, Mong-Lien Wang, Shih-Hwa Chiou, Shih-Jen Chen
Previous studies have found that metformin can reduce cardiovascular risk, but its association with retinal vein occlusion (RVO) is unknown. In this population-based cohort study using the Taiwan National Health Insurance Research Database (NHIRD), we demonstrated the protective effect of metformin against RVO in diabetes mellitus (DM) and explored the incidence rate and factors associated with RVO development in general and diabetic populations. One million patients were randomly selected from the registry files of the NHIRD, and all their claims data were collected for the 1996-2011 period...
2017: PloS One
https://www.readbyqxmd.com/read/29129247/association-between-influenza-vaccination-and-reduced-risks-of-major-adverse-cardiovascular-events-in-elderly-patients
#13
Ming-Hsien Chiang, Hau-Hsin Wu, Chia-Jen Shih, Yung-Tai Chen, Shu-Chen Kuo, Te-Li Chen
BACKGROUND: This study was conducted to determine the protective effect of influenza vaccine against primary major adverse cardiovascular events (MACEs) in elderly patients, especially those with influenza-like illness (ILI). METHODS: This retrospective, population-based case-control study of an elderly population (age≥65 years) was conducted using Taiwan's National Health Insurance Research Database (2000-2013). One control was selected for each MACE case (n=80,363 each), matched according to age, year of study entry, and predisposing factors for MACEs...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29122803/a-population-based-case-control-study-of-hospitalisation-due-to-head-injuries-among-bicyclists-and-motorcyclists-in-taiwan
#14
Chih-Wei Pai, Yi-Chu Chen, Hsiao-Yu Lin, Ping-Ling Chen
INTRODUCTION: According to official statistics in Taiwan, the main body region of injury causing bicyclist deaths is the head, and bicyclists are 2.6 times more likely to be fatally injured than motorcyclists. There is currently a national helmet law for motorcyclists but not for bicyclists. OBJECTIVES: The primary aim of this study was to determine whether bicyclist casualties have higher odds of head-related hospitalisation than motorcyclists. This study also aims to investigate the determinants of head injury-related hospitalisation among bicyclists and motorcyclists...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29121292/preadmission-statin-use-improves-the-outcome-of-less-severe-sepsis-patients-a-population-based-propensity-score-matched-cohort-study
#15
M G Lee, C-C Lee, C-C Lai, T-C Hsu, L Porta, M Lee, S-S Chang, K-L Chien, Y-M Chen
Background: Randomized controlled trials on the post-admission use of statins in sepsis patients have not shown a survival benefit. Whether preadmission use of statins would confer any beneficial effects in sepsis patients has not been well studied. Methods: We conducted a population-based cohort study on a national health insurance claims database between 1999 and 2011. Sepsis patients were identified by ICD-9 codes compatible with the third International consensus definitions for sepsis...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29120202/collaboration-confidentiality-and-care
#16
Latoya S Moss
There is an increasing call to attend to the needs of students in distress (Reynolds, 2013). Furthermore, research has begun to highlight links between distress, risky, or dangerous behaviors as well as issues in mental health in the higher education population (Deasy, Coughlan, Pironom, Jourdan, & Mannix-McNamara, 2014). The National Alliance on Mental Health and the Jed Foundation (National Alliance on Mental Illness & the Jed Foundation, 2016) estimate that about 20% of enrolled college students will face some type of mental illness...
November 2017: Psychological Services
https://www.readbyqxmd.com/read/29113391/association-of-type-2-diabetes-with-liver-cirrhosis-a-nationwide-cohort-study
#17
Ping-Hsin Hsieh, Jing-Yang Huang, Oswald Ndi Nfor, Chia-Chi Lung, Chien-Chang Ho, Yung-Po Liaw
Background: The link between the subcategories of liver cirrhosis and type 2 diabetes is not well known. We investigated the association of type 2 diabetes mellitus with alcoholic cirrhosis and cirrhosis without alcohol. Methods: This nationwide cohort study used the Taiwan National Health Insurance Research Database. Cirrhotic individuals and their matched controls were identified from 2001-2008. In all, 9 313 cirrhotic patients aged 20 years or older were matched by age, sex, and index date with the non-cirrhotic individuals (n = 37 252)...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113328/diabetes-and-risk-of-kaposi-s-sarcoma-effects-of-high-glucose-on-reactivation-and-infection-of-kaposi-s-sarcoma-associated-herpesvirus
#18
Pey-Jium Chang, Yao-Hsu Yang, Pau-Chung Chen, Lee-Wen Chen, Shie-Shan Wang, Ying-Ju Shih, Li-Yu Chen, Chi-Jen Chen, Chien-Hui Hung, Chun-Liang Lin
Patients with diabetes are generally prone to pathogen infection and tumor progression. Here, we investigated the potential association between diabetes and Kaposi's sarcoma (KS), a tumor linked to infection with Kaposi's sarcoma-associated herpesvirus (KSHV). By using Taiwan's National Health Insurance Research Database, we found that diabetes is statistically associated with increased risk of KS in a case-control study. Since a high level of blood sugar is the hallmark of diabetes, we determined whether high glucose promotes both KSHV reactivation and infection, which are crucial for KS pathogenesis...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112198/co-aggregation-of-major-psychiatric-disorders-in-individuals-with-first-degree-relatives-with-schizophrenia-a-nationwide-population-based-study
#19
C-M Cheng, W-H Chang, M-H Chen, C-F Tsai, T-P Su, C-T Li, S-J Tsai, J-W Hsu, K-L Huang, W-C Lin, T-J Chen, Y-M Bai
A previous genetic study has suggested that schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) share common disease-associated genes. However, whether individuals with first-degree relatives (FDRs) with schizophrenia have a higher risk of these major psychiatric disorders requires further investigation. This study used Taiwan's National Health Insurance Research Database and identified 151 650 patients with schizophrenia and 227 967 individuals with FDRs with schizophrenia...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29110252/risk-of-psoriasis-following-terbinafine-or-itraconazole-treatment-for-onychomycosis-a-population-based-case-control-comparative-study
#20
Hsien-Yi Chiu, Wei-Lun Chang, Tsen-Fang Tsai, Yi-Wen Tsai, Ming-Neng Shiu
INTRODUCTION: Several case studies have reported an association between antifungal drug use and psoriasis risk. OBJECTIVE: The objective of this study was to investigate the association between terbinafine/itraconazole exposure and psoriasis incidence. METHODS: Among patients with onychomycosis in the Taiwan National Health Insurance Research Database, 3831 incident psoriasis cases were identified during 2004-2010 and compared with 3831 age- and sex-matched controls with the same look-back period...
November 6, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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