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https://www.readbyqxmd.com/read/29220868/incidence-and-prevalence-of-hepatitis-b-in-patients-with-diabetes-mellitus-in-the-uk-a-population-based-cohort-study-using-the-uk-clinical-practice-research-datalink
#1
Germano L C Ferreira, Cinzia Marano, Laurence De Moerlooze, Adrienne Guignard, Yang Feng, Yassine El Hahi, Tjeerd van Staa
We assessed the incidence and prevalence of hepatitis B (Hep B) in patients with or without diabetes mellitus using the UK Clinical Practice Research Datalink. This was a retrospective, observational study of diabetic and non-diabetic cohorts aged 0-80 years using Clinical Practice Research Datalink (NCT02324218). Incidence rates (IR) for each cohort were calculated. Crude and adjusted (Poisson Regression) IR ratios (IRR) were estimated with 95% confidence intervals (CI) to compare the cohorts. Hep B prevalence stratified by age, and hospitalisation related to Hep B were also calculated...
December 8, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29218780/under-treatment-of-hypertension-and-hypercholesterolemia-in-children-and-adolescents-with-type-1-diabetes-long-term-follow-up-on-time-trends-in-the-occurrence-of-cardiovascular-disease-risk-factors-and-medications-use
#2
Fariba Ahmadizar, Patrick Souverein, Anthonius de Boer, Anke H Maitland-van der Zee
AIMS: 1) To evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and occurrence of CVD events in children with type 1 diabetes mellitus (T1DM), and 2) To assess determinants of under-treatment of CVD risk factors. METHODS: A retrospective cohort study was conducted in 3,728 children (<19 years) with T1DM and up to 5 age and gender-matched diabetes-free children (reference cohort) (n=18,513) using data from the Clinical Practice Research Datalink (CPRD)...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29208621/retrospective-multicohort-analysis-of-the-clinical-practice-research-datalink-cprd-to-determine-differences-in-the-cost-of-medication-wastage-dispensing-fees-and-prescriber-time-of-issuing-either-short-60-days-or-long-%C3%A2-60-days-prescription-lengths-in-primary
#3
Brett Doble, Rupert Payne, Amelia Harshfield, Edward C F Wilson
OBJECTIVES: To investigate patterns of early repeat prescriptions and treatment switching over an 11-year period to estimate differences in the cost of medication wastage, dispensing fees and prescriber time for short (<60 days) and long (≥60 days) prescription lengths from the perspective of the National Health Service in the UK. SETTING: Retrospective, multiple cohort study of primary care prescriptions from the Clinical Practice Research Datalink. PARTICIPANTS: Five random samples of 50 000 patients each prescribed oral drugs for (1) glucose control in type 2 diabetes mellitus (T2DM); (2) hypertension in T2DM; (3) statins (lipid management) in T2DM; (4) secondary prevention of myocardial infarction; and (5) depression...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29205633/a-combined-connectivity-mapping-and-pharmacoepidemiology-approach-to-identify-existing-medications-with-breast-cancer-causing-or-preventing-properties
#4
John Busby, Liam Murray, Ken Mills, Shu-Dong Zhang, Fabio Liberante, Chris R Cardwell
PURPOSE: We applied a novel combined connectivity mapping and pharmacoepidemiological approach to identify medications that alter breast cancer risk. METHODS: The connectivity mapping process identified 6 potentially cancer-causing (meloxicam, azithromycin, rizatriptan, citalopram, rosiglitazone, and verapamil) and 4 potentially cancer-preventing (bendroflumethiazide, sertraline, fluvastatin, and budesonide) medications that were suitable for pharmacoepidemiological investigation...
December 4, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29204655/blood-pressure-trajectories-in-the-20-years-before-death
#5
João Delgado, Kirsty Bowman, Alessandro Ble, Jane Masoli, Yang Han, William Henley, Scott Welsh, George A Kuchel, Luigi Ferrucci, David Melzer
Importance: There is mixed evidence that blood pressure (BP) stabilizes or decreases in later life. It is also unclear whether BP trajectories reflect advancing age, proximity to end of life, or selective survival of persons free from hypertension. Objective: To estimate individual patient BP for each of the 20 years before death and identify potential mechanisms that may explain trajectories. Design, Study, and Participants: We analyzed population-based Clinical Practice Research Datalink primary care and linked hospitalization electronic medical records from the United Kingdom, using retrospective cohort approaches with generalized linear mixed-effects modeling...
December 4, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29201995/protective-effect-of-antirheumatic-drugs-on-dementia-in-rheumatoid-arthritis-patients
#6
Andy Judge, Cesar Garriga, Nigel K Arden, Simon Lovestone, Dani Prieto-Alhambra, Cyrus Cooper, Christopher J Edwards
Introduction: Rheumatoid arthritis is a systemic inflammatory disease, and classical disease-modifying antirheumatic drugs (cDMARDs) have proven efficacy. It is unknown what impact cDMARDs might have on dementia as an outcome. Methods: Incident diagnoses of rheumatoid arthritis in persons over 18 years from 1995 to 2011 were identified from the UK Clinical Practice Research Datalink. There were 3876 cDMARD users and were propensity score matched to 1938 nonusers, on a wide range of confounders...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29193554/do-delays-in-data-availability-limit-the-implementation-of-near-real-time-vaccine-safety-surveillance-using-the-clinical-practice-research-datalink
#7
Andreia Leite, Sara L Thomas, Nick J Andrews
PURPOSE: Near real-time vaccine safety surveillance (NRTVSS) using electronic health records has been used to detect timely vaccine safety signals. Trial implementation of NRTVSS using the Clinical Practice Research Datalink (CPRD) has shown that there is limited power to detect safety signals for rare events. Delays in recording outcomes and receiving data influence the power and timeliness to identify a signal. Our work aimed to compare how different sources of delays influence power and expected time to signal to implement NRTVSS using CPRD...
November 28, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29190680/identifying-social-factors-amongst-older-individuals-in-linked-electronic-health-records-an-assessment-in-a-population-based-study
#8
Anu Jain, Albert J van Hoek, Jemma L Walker, Rohini Mathur, Liam Smeeth, Sara L Thomas
Identification and quantification of health inequities amongst specific social groups is a pre-requisite for designing targeted healthcare interventions. This study investigated the recording of social factors in linked electronic health records (EHR) of individuals aged ≥65 years, to assess the potential of these data to identify the social determinants of disease burden and uptake of healthcare interventions. Methodology was developed for ascertaining social factors recorded on or before a pre-specified index date (01/01/2013) using primary care data from Clinical Practice Research Datalink (CPRD) linked to hospitalisation and deprivation data in a cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/29174292/temporal-trends-and-patterns-in-heart-failure-incidence-a-population-based-study-of-4-million-individuals
#9
Nathalie Conrad, Andrew Judge, Jenny Tran, Hamid Mohseni, Deborah Hedgecott, Abel Perez Crespillo, Moira Allison, Harry Hemingway, John G Cleland, John J V McMurray, Kazem Rahimi
BACKGROUND: Large-scale and contemporary population-based studies of heart failure incidence are needed to inform resource planning and research prioritisation but current evidence is scarce. We aimed to assess temporal trends in incidence and prevalence of heart failure in a large general population cohort from the UK, between 2002 and 2014. METHODS: For this population-based study, we used linked primary and secondary electronic health records of 4 million individuals from the Clinical Practice Research Datalink (CPRD), a cohort that is representative of the UK population in terms of age and sex...
November 21, 2017: Lancet
https://www.readbyqxmd.com/read/29171906/-risk-of-a-first-ever-acute-myocardial-infarction-and-all-cause-mortality-with-sulphonylurea-treatment-a-population-based-cohort-study
#10
Judith van Dalem, Martijn Cgj Brouwers, Coen DA Stehouwer, André Krings, Olaf H Klungel, Johanna Hm Driessen, Frank de Vries, Andrea M Burden
We investigated the association between the current use of individual sulphonylureas and the risk of a first ever acute myocardial infarction (AMI) and all-cause mortality, in a population-based cohort study using primary care data from the Clinical Practice Research Datalink (CPRD) database (2004-2012). New users (N=121,869) with at least one prescription for a non-insulin antidiabetic agent, and aged ≥18 years were included. The first prescription defined start of follow-up. Time-dependent Cox proportional hazards models were used to estimate the risk of a first ever AMI and all-cause mortality associated with the use of individual sulphonylureas, and other non-insulin glucose-lowering drugs...
November 24, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29170293/identifying-clinical-features-in-primary-care-electronic-health-record-studies-methods-for-codelist-development
#11
Jessica Watson, Brian D Nicholson, Willie Hamilton, Sarah Price
OBJECTIVE: Analysis of routinely collected electronic health record (EHR) data from primary care is reliant on the creation of codelists to define clinical features of interest. To improve scientific rigour, transparency and replicability, we describe and demonstrate a standardised reproducible methodology for clinical codelist development. DESIGN: We describe a three-stage process for developing clinical codelists. First, the clear definition a priori of the clinical feature of interest using reliable clinical resources...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29161254/lansoprazole-use-and-tuberculosis-incidence-in-the-united-kingdom-clinical-practice-research-datalink-a-population-based-cohort
#12
Tom A Yates, Laurie A Tomlinson, Krishnan Bhaskaran, Sinead Langan, Sara Thomas, Liam Smeeth, Ian J Douglas
BACKGROUND: Recent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity. There is no evidence that, in clinical practice, lansoprazole can treat or prevent incident tuberculosis (TB) disease. METHODS AND FINDINGS: We studied a cohort of new users of lansoprazole, omeprazole, or pantoprazole from the United Kingdom Clinical Practice Research Datalink to determine whether lansoprazole users have a lower incidence of TB disease than omeprazole or pantoprazole users...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29150473/patient-level-and-practice-level-factors-associated-with-consultation-duration-a-cross-sectional-analysis-of-over-one-million-consultations-in-english-primary-care
#13
Sarah Stevens, Clare Bankhead, Toqir Mukhtar, Rafael Perera-Salazar, Tim A Holt, Chris Salisbury, F D Richard Hobbs
OBJECTIVES: Consultation duration has previously been shown to be associated with patient, practitioner and practice characteristics. However, previous studies were conducted outside the UK, considered only small numbers of general practitioner (GP) consultations or focused primarily on practitioner-level characteristics. We aimed to determine the patient-level and practice-level factors associated with duration of GP and nurse consultations in UK primary care. DESIGN AND SETTING: Cross-sectional data were obtained from English general practices contributing to the Clinical Practice Research Datalink (CPRD) linked to data on patient deprivation and practice staffing, rurality and Quality and Outcomes Framework (QOF) achievement...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29138197/incidence-of-shoulder-dislocations-in-the-uk-1995-2015-a-population-based-cohort-study
#14
Anjali Shah, Andrew Judge, Antonella Delmestri, Katherine Edwards, Nigel K Arden, Daniel Prieto-Alhambra, Tim A Holt, Rafael A Pinedo-Villanueva, Sally Hopewell, Sarah E Lamb, Amar Rangan, Andrew J Carr, Gary S Collins, Jonathan L Rees
OBJECTIVE: This cohort study evaluates the unknown age-specific and gender-specific incidence of primary shoulder dislocations in the UK. SETTING: UK primary care data from the Clinical Practice Research Datalink (CPRD) were used to identify patients aged 16-70 years with a shoulder dislocation during 1995-2015. Coding of primary shoulder dislocations was validated using the CPRD general practitioner questionnaire service. PARTICIPANTS: A cohort of 16 763 patients with shoulder dislocation aged 16-70 years during 1995-2015 were identified...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29135571/validation-of-cancer-cases-using-primary-care-cancer-registry-and-hospitalization-data-in-the-uk
#15
Andrea V Margulis, Joan Fortuny, James A Kaye, Brian Calingaert, Maria Reynolds, Estel Plana, Lisa J McQuay, Willem Jan Atsma, Billy Franks, Stefan de Vogel, Susana Perez-Gutthann, Alejandro Arana
BACKGROUND: In the United Kingdom, hospital or cancer registry data can be linked to electronic medical records for a subset of general practices and years. METHODS: We used Clinical Practice Research Datalink data (2004-2012) from patients treated for overactive bladder. We electronically identified provisional cases of 10 common cancers in General Practitioner Online Database data and validated them by medical profile review. In practices with linkage to Hospital Episodes Statistics and National Cancer Data Repository (2004-2010), we validated provisional cancer cases against these data sources...
November 9, 2017: Epidemiology
https://www.readbyqxmd.com/read/29135336/a-retrospective-observational-analysis-of-post-pandemic-influenza-related-outcomes-in-the-united-kingdom-2010-2014
#16
Sankarasubramanian Rajaram, Witold Wiecek, Richard Lawson, Betina Blak, Yanli Zhao, Judith Hackett, Robert Brody, Tehseen Salimi, Billy Amzal, Vishal Patel
This study set out to evaluate influenza- and respiratory-related illnesses recorded during primary care physician consultations in England following the H1N1 pandemic in 2009 and to enable the development of a dynamic disease model. Data were obtained from the Clinical Practice Research Datalink of primary care records over four influenza seasons (2010-2014). The primary outcome of the study was incidence of influenza- and respiratory-related diagnoses, calculated per practice and by season and age group. Upper respiratory tract infection diagnoses were most frequently recorded (mean seasonal practice level incidence; 3,762 consultations per 100,000 [SD = 1,989]), and influenza-related diagnoses were least frequently recorded across all seasons, except one...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29133489/continuity-of-primary-care-and-emergency-hospital-admissions-among-older-patients-in-england
#17
Peter Tammes, Sarah Purdy, Chris Salisbury, Fiona MacKichan, Daniel Lasserson, Richard W Morris
PURPOSE: Secondary health care services have been under considerable pressure in England as attendance rates increase, resulting in longer waiting times and greater demands on staff. This study's aim was to examine the association between continuity of care and risk of emergency hospital admission among older adults. METHODS: We analyzed records from 10,000 patients aged 65 years and older in 2012 within 297 English general practices obtained from the Clinical Practice Research Datalink and linked with Hospital Episode Statistics...
November 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/29126386/venous-thromboembolism-and-mortality-in-breast-cancer-cohort-study-with-systematic-review-and-meta-analysis
#18
Umair T Khan, Alex J Walker, Sadaf Baig, Tim R Card, Cliona C Kirwan, Matthew J Grainge
BACKGROUND: Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in breast cancer patients is conflicting. We present data from a large cohort of patients from the UK and pool these with previous data from a systematic review. METHODS: Using the Clinical Practice Research Datalink (CPRD) dataset, we identified a cohort of 13,202 breast cancer patients, of whom 611 were diagnosed with VTE between 1997 and 2006 and 12,591 did not develop VTE...
November 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29122547/low-dose-aspirin-use-does-not-increase-survival-in-2-independent-population-based-cohorts-of-patients-with-esophageal-or-gastric-cancer
#19
Andrew D Spence, John Busby, Brian T Johnston, John A Baron, Carmel M Hughes, Helen G Coleman, Chris R Cardwell
BACKGROUND & AIMS: Pre-clinical studies have shown aspirin to have anti-cancer properties and epidemiologic studies have associated aspirin use with longer survival times of patients with cancer. We studied 2 large cohorts to determine the association between aspirin use and cancer-specific mortality in patients with esophageal or gastric cancer. METHODS: We performed a population-based study using cohorts of patients newly diagnosed with esophageal or gastric cancer, identified from cancer registries in England from 1998 through 2012 and the Scottish Cancer Registry from 2009 through 2012...
November 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29121851/outputs-and-growth-of-primary-care-databases-in-the-united-kingdom-bibliometric-analysis
#20
Zain Chaudhry, Fahmida Mannan, Angela Gibson-White, Usama Syed, Shirin Ahmed, Antonis Kousoulis, Azeem Majeed
BACKGROUND: Electronic health database (EHD) data is increasingly used by researchers. The major United Kingdom EHDs are the 'Clinical Practice Research Datalink' (CPRD), 'The Health Improvement Network' (THIN) and 'QResearch'. Over time, outputs from these databases have increased, but have not been evaluated. OBJECTIVE: This study compares research outputs from CPRD, THIN and QResearch assessing growth and publication outputs over a 10-year period (2004-2013)...
October 17, 2017: Journal of Innovation in Health Informatics
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