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https://www.readbyqxmd.com/read/28077689/giant-cell-arteritis-and-vascular-disease-risk-factors-and-outcomes-a-cohort-study-using-uk-clinical-practice-research-datalink
#1
Lin Li, Tuhina Neogi, Susan Jick
OBJECTIVE: To evaluate the associations between GCA and vascular diseases and other comorbidities in patients with GCA compared with non-vasculitis patients. METHODS: Using the UK-based Clinical Practice Research Datalink we identified 9778 newly diagnosed GCA patients in 1990-2014, and up to 10 non-vasculitis patients randomly matched to each case on age, sex, practice and years of history before cohort entry. We compared the distributions of 9 different pre-existing vascular diseases and 11 other comorbidities, and risks of incident vascular diseases and other comorbidities after cohort entry between GCA and non-vasculitis patients...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28069618/adherence-to-guidelines-for-creatinine-and-potassium-monitoring-and-discontinuation-following-renin-angiotensin-system-blockade-a-uk-general-practice-based-cohort-study
#2
Morten Schmidt, Kathryn E Mansfield, Krishnan Bhaskaran, Dorothea Nitsch, Henrik Toft Sørensen, Liam Smeeth, Laurie A Tomlinson
OBJECTIVES: To examine adherence to serum creatinine and potassium monitoring and discontinuation guidelines following initiation of treatment with ACE inhibitors (ACEI) or angiotensin receptor blockers (ARBs); and whether high-risk patients are monitored. DESIGN: A general practice-based cohort study using electronic health records from the UK Clinical Practice Research Datalink and Hospital Episode Statistics. SETTING: UK primary care, 2004-2014...
January 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28068620/temporal-trends-in-antidepressant-prescribing-to-children-in-uk-primary-care-2000-2015
#3
Jane Sarginson, Roger T Webb, S Jill Stocks, Aneez Esmail, Shruti Garg, Darren M Ashcroft
BACKGROUND: The prevalence of antidepressant prescribing in children and adolescents increased steadily in the United States and parts of Europe between 2005 and 2012 despite regulatory safety warnings. Little is known about the characteristics of those being prescribed antidepressants for the first time. METHODS: A longitudinal study of antidepressant prescribing in 3-17 year olds was carried out using data from the UK Clinical Practice Research Datalink (CPRD) between 2000 and 2015...
January 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28064207/rheumatoid-arthritis-is-getting-less-frequent-results-of-a-nationwide-population-based-cohort-study
#4
Abhishek Abhishek, Michael Doherty, Chang-Fu Kuo, Christian D Mallen, Weiya Zhang, Matthew J Grainge
OBJECTIVES: The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK. METHODS: This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28040244/serious-adverse-effects-associated-with-glucocorticoid-therapy-in-patients-with-giant-cell-arteritis-gca-a-nested-case-control-analysis
#5
Jessica C Wilson, Khaled Sarsour, Neil Collinson, Katie Tuckwell, David Musselman, Micki Klearman, Pavel Napalkov, Susan S Jick, John H Stone, Christoph R Meier
OBJECTIVE: Giant cell arteritis (GCA) is an inflammatory vasculitis preferentially affecting large and medium-sized arteries. High-dose oral glucocorticoids (GCs) are the mainstay of GCA therapy. Using data from the UK Clinical Practice Research Datalink (CPRD), we examined the risk of oral GC-related serious adverse events (SAEs) in a UK population of patients with giant cell arteritis (GCA). METHODS: We conducted a series of nested case-control analyses in GCA patients to examine the effect of increasing dose of prednisolone on the risk of developing diabetes, glaucoma, osteoporosis, fractures, serious infection requiring hospitalization, and death...
November 28, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28039870/outcomes-of-treated-hypertension-at-age-80-and-older-cohort-analysis-of-79-376-individuals
#6
João Delgado, Jane A H Masoli, Kirsty Bowman, W David Strain, George A Kuchel, Kate Walters, Louise Lafortune, Carol Brayne, David Melzer, Alessandro Ble
OBJECTIVES: To estimate outcomes according to attained blood pressure (BP) in the oldest adults treated for hypertension in routine family practice. DESIGN: Cohort analysis of primary care inpatient and death certificate data for individuals with hypertension. SETTING: Primary care practices in England (Clinical Practice Research Datalink). PARTICIPANTS: Individuals aged 80 and older taking antihypertensive medication and free of dementia, cancer, coronary heart disease, stroke, heart failure, and end-stage renal failure at baseline...
December 30, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28026911/managing-glycaemia-in-older-people-with-type-2-diabetes-a-retrospective-primary-care-based-cohort-study-with-economic-assessment-of-patient-outcomes
#7
Jason Gordon, Phil McEwan, Marc Evans, Jorge Puelles, Alan Sinclair
AIMS: To describe the relative health and economic outcomes associated with different therapeutic approaches to managing older patients with type 2 diabetes failing metformin (M) monotherapy and escalated to second-line treatment. METHODS: The Clinical Practice Research Datalink (CPRD) database was used to inform a retrospective observational cohort study of patients with type 2 diabetes treated with M monotherapy requiring escalation (addition or switch) to a second-line oral regimen from 01-01-2008 to 31-12-2014...
December 27, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28013209/the-incidence-prevalence-and-mortality-of-granulomatosis-with-polyangiitis-in-the-uk-clinical-practice-research-datalink
#8
Fiona A Pearce, Matthew J Grainge, Peter C Lanyon, Richard A Watts, Richard B Hubbard
OBJECTIVE: To estimate the incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK. METHODS: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (HES). We calculated incidence rate ratios, adjusted for age, gender and ethnicity, using Poisson regression. RESULTS: We identified 462 cases diagnosed between 1997 and 2013. Our overall estimate of incidence was 11...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/28007397/impact-of-the-national-rotavirus-vaccination-programme-on-acute-gastroenteritis-in-england-and-associated-costs-averted
#9
Sara L Thomas, Jemma L Walker, Justin Fenty, Katherine E Atkins, Alex J Elliot, Helen E Hughes, Julia Stowe, Shamez Ladhani, Nick J Andrews
BACKGROUND: Introduction of infant oral rotavirus vaccination in the UK in July 2013 has resulted in decreased hospitalisations and Emergency Department (ED) visits for acute gastroenteritis (AGE), for both adults and children. We investigated reductions in AGE incidence seen in primary care in the two years after vaccine introduction, and estimated the healthcare costs averted across healthcare settings in the first year of the vaccination programme. METHODS: We used primary care data from the Clinical Practice Research Datalink and age-stratified time-series analyses to derive adjusted incidence rate ratios (IRRa) for AGE in the first two years of the post-vaccination era (July 2013-April 2015) compared to the pre-vaccination era (July 2008-June 2013)...
December 19, 2016: Vaccine
https://www.readbyqxmd.com/read/28003286/prescription-of-renin-angiotensin-system-blockers-and-risk-of-acute-kidney-injury-a-population-based-cohort-study
#10
Kathryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaran, Laurie A Tomlinson
OBJECTIVE: To investigate whether there is an association between use of ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB) and risk of acute kidney injury (AKI). STUDY DESIGN: We conducted a new-user cohort study of the rate of AKI among users of common antihypertensives. SETTING: UK primary care practices contributing to the Clinical Practice Research Datalink (CPRD) eligible for linkage to hospital records data from the Hospital Episode Statistics (HES) database between April 1997 and March 2014...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27998911/life-expectancy-and-cause-specific-mortality-in-type-2-diabetes-a-population-based-cohort-study-quantifying-relationships-in-ethnic-subgroups
#11
Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Iain Buchan, Naveed Sattar, Martin K Rutter, Darren M Ashcroft
OBJECTIVES: This study 1) investigated life expectancy and cause-specific mortality rates associated with type 2 diabetes and 2) quantified these relationships in ethnic subgroups. RESEARCH DESIGN AND METHODS: This was a cohort study using Clinical Practice Research Datalink data from 383 general practices in England with linked hospitalization and mortality records. A total of 187,968 patients with incident type 2 diabetes from 1998 to 2015 were matched to 908,016 control subjects...
December 20, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27986803/androgen-deprivation-therapy-for-prostate-cancer-and-the-risk-of-hospitalisation-for-community-acquired-pneumonia
#12
Blánaid M Hicks, Hui Yin, Franck Bladou, Pierre Ernst, Laurent Azoulay
BACKGROUND: Androgens have been shown to influence both the immune system and lung tissue, raising the hypothesis that androgen deprivation therapy (ADT) for prostate cancer may increase the risk of pneumonia. Thus, the aim of this study was to determine whether ADT is associated with an increased risk of hospitalisation for community-acquired pneumonia in patients with prostate cancer. METHODS: This was a population-based cohort study using the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episode Statistics repository...
December 16, 2016: Thorax
https://www.readbyqxmd.com/read/27965247/can-commonly-prescribed-drugs-be-repurposed-for-the-prevention-or-treatment-of-alzheimer-s-and-other-neurodegenerative-diseases-protocol-for-an-observational-cohort-study-in-the-uk-clinical-practice-research-datalink
#13
Venexia M Walker, Neil M Davies, Tim Jones, Patrick G Kehoe, Richard M Martin
INTRODUCTION: Current treatments for Alzheimer's and other neurodegenerative diseases have only limited effectiveness meaning that there is an urgent need for new medications that could influence disease incidence and progression. We will investigate the potential of a selection of commonly prescribed drugs, as a more efficient and cost-effective method of identifying new drugs for the prevention or treatment of Alzheimer's disease, non-Alzheimer's disease dementias, Parkinson's disease and amyotrophic lateral sclerosis...
December 13, 2016: BMJ Open
https://www.readbyqxmd.com/read/27943565/long-term-use-of-dipeptidyl-peptidase-4-inhibitors-and-risk-of-fracture-a-retrospective-population-based-cohort-study
#14
J H M Driessen, J P W van den Bergh, H A W van Onzenoort, R M A Henry, H G M Leufkens, F de Vries
INTRODUCTION: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fracture as compared to patients without T2DM. It has been suggested based on clinical trial data that use of dipeptidyl peptidase-4 inhibitors (DPP4-Is), an anti-hyperglycaemic drug, is associated with a decreased risk of fracture as compared to patients with and without T2DM. However, observational studies have failed to show this association, which might be due to the short duration of use. Therefore, the aim of the present study was to investigate the association between long-term DPP4-I use and risk of fracture...
December 10, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27943383/statin-potency-and-the-risk-of-hospitalization-for-community-acquired-pneumonia
#15
Ju-Young Shin, Maria Eberg, Pierre Ernst, Kristian B Filion
AIM: Previous studies suggest that statins may have beneficial respiratory effects. However, it is unclear if these purported benefits vary with statin potency. Our objective was to determine if higher potency statins, compared with lower potency statins, were associated with a reduced risk of hospitalization for community-acquired pneumonia (HCAP). METHODS: We conducted a nested case-control analysis of a retrospective, population-based cohort of new users of statins using data extracted from the United Kingdom's Clinical Practice Research Datalink and Hospital Episode Statistics...
December 9, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27920578/recording-of-hospitalizations-for-acute-exacerbations-of-copd-in-uk-electronic-health-care-records
#16
Kieran J Rothnie, Hana Müllerová, Sara L Thomas, Joht S Chandan, Liam Smeeth, John R Hurst, Kourtney Davis, Jennifer K Quint
BACKGROUND: Accurate identification of hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) within electronic health care records is important for research, public health, and to inform health care utilization and service provision. We aimed to develop a strategy to identify hospitalizations for AECOPD in secondary care data and to investigate the validity of strategies to identify hospitalizations for AECOPD in primary care data. METHODS: We identified patients with chronic obstructive pulmonary disease (COPD) in the Clinical Practice Research Datalink (CPRD) with linked Hospital Episodes Statistics (HES) data...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27920512/the-burden-of-chronic-obstructive-pulmonary-disease-associated-with-maintenance-monotherapy-in-the-uk
#17
Susan C Edwards, Sian E Fairbrother, Anna Scowcroft, Gavin Chiu, Andrew Ternouth, Brian J Lipworth
BACKGROUND: This study characterized a cohort of chronic obstructive pulmonary disease (COPD) patients on maintenance bronchodilator monotherapy for ≥6 months to establish their disease burden, measured by health care utilization. METHODS: Data were extracted from the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics. The monotherapy period spanned the first prescription of a long-acting β2-adrenergic agonist or a long-acting muscarinic antagonist until the end of the study (December 31, 2013) or until step up to dual/triple therapy, for example, addition of another long-acting bronchodilator, an inhaled corticosteroid, or both...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27919934/development-and-validation-of-risk-prediction-model-for-venous-thromboembolism-in-postpartum-women-multinational-cohort-study
#18
Alyshah Abdul Sultan, Joe West, Matthew J Grainge, Richard D Riley, Laila J Tata, Olof Stephansson, Kate M Fleming, Catherine Nelson-Piercy, Jonas F Ludvigsson
OBJECTIVE:  To develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum). DESIGN:  Cohort study. SETTING:  Records from England based Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and data from Sweden based registry. PARTICIPANTS:  All pregnant women registered with CPRD-HES linked data between 1997 and 2014 and Swedish medical birth registry between 2005 and 2011 with postpartum follow-up...
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27919514/the-psychological-impact-of-symptoms-related-to-esophagogastric-cancer-resection-presenting-in-primary-care-a-national-linked-database-study
#19
G Bouras, S R Markar, E M Burns, J R Huddy, A Bottle, T Athanasiou, A Darzi, G B Hanna
BACKGROUND: The objective was to evaluate incidence, risk factors and impact of postoperative symptoms following esophagogastric cancer resection in primary care. METHODS: Patients undergoing esophagogastrectomy for cancer from 1998 to 2010 with linked records in Clinical Practice Research Datalink, Hospital Episodes Statistics and Office of National Statistics databases were studied. The recording of codes for reflux, dysphagia, dyspepsia, nausea, vomiting, dumping, diarrhea, steatorrhea, appetite loss, weight loss, pain and fatigue were identified up to 12 months postoperatively...
November 9, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27918771/association-of-selective-serotonin-reuptake-inhibitors-with-the-risk-for-spontaneous-intracranial-hemorrhage
#20
Christel Renoux, Sarah Vahey, Sophie Dell'Aniello, Jean-François Boivin
Importance: Selective serotonin reuptake inhibitors (SSRIs) may increase the risk for spontaneous intracranial hemorrhage (ICH), an effect that is in theory linked to the strength of inhibition of serotonin reuptake of an antidepressant. However, whether antidepressants that are strong inhibitors of serotonin reuptake actually increase the risk for ICH and the effect of concomitant use of antithrombotics are unknown. Objectives: To assess the risk for ICH associated with the use of SSRIs compared with tricyclic antidepressants (TCAs) among new users of antidepressants and according to the relative affinity of the antidepressant for the serotonin transporter and to assess whether concomitant use of antithrombotics modifies this risk...
December 5, 2016: JAMA Neurology
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