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https://www.readbyqxmd.com/read/28560835/a-comparison-of-pulse-oximetry-and-cerebral-oxygenation-in-children-with-severe-sleep-apnea-hypopnea-syndrome-a-pilot-study
#1
Jorge Olmo Arroyo, Sonia Khirani, Alessandro Amaddeo, Lucie Griffon, Livio De Sanctis, Philippe Pouard, Brigitte Fauroux
Near infrared spectroscopy (NIRS) has been used to assess the impact of obstructive sleep apnea-hypopnea syndrome (OSAHS) on cerebral oxygenation. However, the relationship between the variations in the cerebral tissue oxygen saturation (ΔTOI) and pulse oximetry (ΔSpO2 ) has not been assessed in children with OSAHS. Consecutive clinically stable children with severe OSAHS [apnea-hypopnea index (AHI) >15 events h(-1) ] diagnosed during a night-time polygraphy with simultaneous recording of cerebral oxygenation with NIRS (NIRO-200NX, Hamamatsu Photonics KK) were included between September 2015 and June 2016...
May 31, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28530254/palatal-surgery-in-a-transoral-robotic-setting-tors-preliminary-results-of-a-retrospective-comparison-between-uvulopalatopharyngoplasty-uppp-expansion-sphincter-pharyngoplasty-esp-and-barbed-repositioning-pharyngoplasty-brp
#2
G Cammaroto, F Montevecchi, G D'Agostino, E Zeccardo, C Bellini, G Meccariello, C Vicini
It has become increasingly clear in the past decade that surgical management of obstructive sleep apnoea hypopnoea syndrome (OSAHS) is most successfully managed with multilevel surgery. We evaluated the outcomes of multilevel interventions comparing three different palatal techniques added to TORS: uvulopalatopharyngoplasty (UPPP), a modified expansion sphincter pharyngoplasty (ESP), inspired by the Pang expansion sphincter pharyngoplasty technique and the latest barbed repositioning pharyngoplasty (BRP). Thirty patients were retrospectively evaluated...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28514291/role-of-microrna-130a-in-the-pathogeneses-of-obstructive-sleep-apnea-hypopnea-syndrome-associated-pulmonary-hypertension-by-targeting-the-gax-gene
#3
Zhe An, Dan Wang, Guang Yang, Wen-Qi Zhang, Jin Ren, Jin-Ling Fu
OBJECTIVE: The purpose of this study was to elucidate the role of microRNA-130a (miR-130a) in obstructive sleep apnea hypopnea syndrome (OSAHS)-associated pulmonary hypertension (PHT) by targeting the growth arrest-specific homeobox (GAX) gene. METHODS: A total of 108 patients with OSAHS-associated PHT were recruited as the OSAHS-associated PHT group and 110 healthy individuals were randomly selected as the normal control group. Human umbilical vein endothelial cells (HUVECs) were selected and divided into the control, miR-130a mimic, mimic negative control (NC), miR-130a inhibitor, and inhibitor-NC groups...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28482446/-effect-of-mandibular-advancement-device-upon-nuclear-factor-%C3%AE%C2%BAb-and-tumor-necrosis-factor-%C3%AE-interleukin-6-in-genioglossus-of-rabbit-with-obstructive-sleep-apnea-hypopnea-syndrome
#4
S L Zhang, C Y Liu, W Wang, X Qiao, H Y Lu
Objective: To investigate the effects of mandibular advancement device (MAD) upon nuclear factor κB (NF-κB), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in the genioglossus. Methods: Eighteen New Zealand white rabbits (male, six months old), in accordance with the random number table, were equally divided into three groups, the control group, obstructive sleep apnea hypopnea syndrome (OSAHS) group and MAD group. All animals were induced to sleep in supine position for 2 hours every morning in the next 8 weeks...
May 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28474074/-measurement-of-temporomandibular-joint-space-of-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#5
Rui Zhao, Wei-Sheng Wen, Ge Yang, Ye Tao, Rui Jia
PURPOSE: This research evaluated the morphological differences of temporomandibular joint (TMJ) between patients with obstructive sleep apnea hypopnea Syndrome (OSAHS) and normal population using magnetic resonance imaging (MRI). METHODS: Eighteen OSAHS patients were admitted from January 2014 to May 2016 and 18 healthy adults were chosen as control. OSAHS patients were divided into three sub-groups (n=6), i.e. the mild group, the moderate group and the severe group, according to apnea and hypopnea index (AHI)...
February 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28469721/vitamin-d-deficiency-and-interleukin-17-relationship-in-severe-obstructive-sleep-apnea-hypopnea-syndrome
#6
Sonia Toujani, Wajih Kaabachi, Meriem Mjid, Kamel Hamzaoui, Jouda Cherif, Majed Beji
PURPOSE: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea-hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17). METHODS: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected...
April 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28465244/perk-eif2%C3%AE-contributes-to-changes-of-insulin-signaling-in-hepg2-cell-induced-by-intermittent-hypoxia
#7
Huahua Yi, Chenjuan Gu, Min Li, Zhiguo Zhang, Qingyun Li, Jing Feng, Jun Zhou, Juan Du
AIMS: Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with abnormal glucose metabolism. Nowadays, endoplasmic reticulum (ER) stress emerges as an important mechanism underlying the development of type 2 diabetes mellitus (T2DM). However, it remains unclear that intermittent hypoxia (IH) could induce ER stress, resulting in abnormality of glucose metabolism. Thu, in the current study we explore the changes of insulin signaling under IH and the role of ER stress underlying these changes...
April 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/28443988/efficacy-of-minimally-invasive-tonsil-surgery-for-treatment-of-obstructive-sleep-apnea-hypopnea-syndrome-in-children
#8
X-Q Zhang, H Wang, J Zhou, P Zeng, Y Zhao, Y Zhang, C Liu, L-Q Jiang, Y-J Lan
This study aimed to investigate the efficacy of minimally invasive tonsil surgery for the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) in children. Tonsil ablation or turbinate reduction was performed on 49 pediatric patients with OSAHS by minimally invasive tonsil surgery. In order to evaluate the efficacy of surgery, a comparison was conducted between pre-operation and post-operation data in terms of the symptoms, signs and polysomnography test. Total effectiveness rate of the surgery was 83...
April 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28422847/correlation-between-calpain-10-single-nucleotide-polymorphisms-and-obstructive-sleep-apnea-hypopnoea-syndrome-with-ischemic-stroke-in-a-chinese-population-a-population-based-study
#9
Wei Zhang, Zhi-Ru Zhao, Chang-Fei Dai, Rong Zhang, Jie Chen, Hui-Juan Tian, Yun-Long Wang, Ji-Hong Sun, Qiu-Fang Lian
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common chronic disorder which is followed by various complications. Calpain-10 belongs to a commonly expressed member of the Calpain-like cysteine protease family, which acts as risk marker for some diseases. The purpose of this study is to elucidate correlation between Calpain-10 single-nucleotide polymorphisms (SNPs) and the incidence of OSAHS followed by ischemic stroke (IS). METHODS: OSAHS patients were divided as OSAHS + IS, OSAHS, and control groups, respectively...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28416157/dentoskeletal-sequellae-after-wearing-of-a-mandibular-advancement-device-in-an-osahs-setting
#10
Amélie Laborde, Cyrille Tison, Elodie Drumez, Emilie Garreau, Joël Ferri, Gwenaël Raoul
Mandibular advancement devices (MAD) are recommended in certain cases for the treatment of obstructive sleep apnea and hypopnea syndrome (OSAHS). The aim of this study was to make a retrospective investigation into the dental and skeletal effects in patients suffering from OSAHS after wearing an MAD, and according to the type of device, rigid or semi-rigid. Cephalometric criteria on lateral cephalograms before and after at least 6 months of treatment were analyzed. Twenty-two patients were included. We observed average labial tipping of the lower incisors (+4...
April 13, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28367199/immune-status-of-children-with-obstructive-sleep-apnea-hypopnea-syndrome
#11
Zihe Zhang, Chunguang Wang
OBJECTIVE: We aimed to evaluate the immune status of children with obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS: Fifty children with OSAHS having the symptoms of "snoring, mouth breathing and suffocating during sleep", who were admitted in our hospital from May 2014 to May 2016, were randomly selected. Another 52 healthy, age- and gender-matched children were enrolled as control subjects after taking informed consent. After admission, the peripheral venous blood was collected...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28355750/-association-between-subjective-and-objective-sleepiness-in-obstructive-sleep-apnea-hypopnea-syndrome-patients
#12
T M Li, R Ren, L Tan, F Lei, X D Tang
Objective: To examine the association between subjective sleepiness and objective sleepiness in Chinese obstructive sleep apnea hypopnea syndrome (OSAHS) patients. Methods: A total of 1 660 patients meeting the diagnostic criteria of OSAHS based on overnight polysomnography from West China Hospital, Sichuan University in the period from Jul 2010 to Jul 2014 were enrolled in the study. The Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT) were to evaluate subjective and objective sleepiness, respectively...
March 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28291635/awareness-of-obstructive-sleep-apnea-hypopnea-syndrome-among-the-general-population-of-the-lorraine-region-of-france
#13
F Arous, J-M Boivin, A Chaouat, C Rumeau, R Jankowski, D T Nguyen
OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) seems to be underdiagnosed. The aim of this study was to assess awareness of OSAHS among the general population of the Lorraine Region of France. METHODS: A descriptive epidemiological study was carried out from July to November 2015 in the Lorraine Region, using an anonymous questionnaire that assessed knowledge of OSAHS-related symptoms and complications. The survey was also circulated on the Internet via social media...
March 10, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28270865/obstructive-sleep-apnoea-hypopnoea-syndrome-in-adults-with-down-syndrome
#14
REVIEW
Elizabeth A Hill
KEY POINTS: Adults with Down syndrome are predisposed to obstructive sleep apnoea/hypopnoea syndrome (OSAHS) due to overlap between the Down syndrome phenotype and OSAHS risk factors.The prevalence of OSAHS in adults with Down syndrome is estimated at 35-42%. This is up to ten-times higher than in the general adult population.Symptoms of OSAHS, including behavioural and emotional disturbances as well as standard symptoms such as sleepiness, should be monitored as part of regular health surveillance in adults with Down syndrome...
December 2016: Breathe
https://www.readbyqxmd.com/read/28238333/obstructive-sleep-apnea-hypopnea-syndrome-in-patients-with-severe-chronic-respiratory-insufficiency
#15
Ana Hernández Voth, Javier Sayas Catalán, Pedro Benavides Mañas, Alicia de Pablo Gafas, Trinidad Díaz Cambriles, Victoria Villena Garrido
INTRODUCTION AND OBJECTIVE: Although sleep disordered breathing is common in patients with a severe chronic respiratory insufficiency (SCRI), there is few information on its prevalence. Our aim was to describe the prevalence and characteristics of the obstructive sleep apnea-hypopnea syndrome (OSAHS) in these patients. MATERIAL AND METHODS: Prospective and observational study carried out on patients with a SCRI included in a waiting list for a lung transplantation and who had undergone a standard polysomnography...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28219167/-therapeutic-effectiveness-of-the-soft-palate-fold-surgery-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#16
M Zhu, X Bai
Objective: To evaluate the relationships between anatomical changes and treatment outcomes after modified velopharyngeal surgery in obstructive sleep apnea hypopnea syndrome (OSAHS) patients with the soft palate drooping. Methods: From November 2011 to November 2015, 44 OSHS patients (AHI 5-30 times/h) with the soft palate drooping determined by Muller test and drug-induced sleep endoscopy (DISE) were randomly selected. Treatment group included 23 patients who underwent modified velopharyngeal surgery, in which uvula was preserved and soft palate was shortened and advanced...
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28218579/effect-of-obstructive-sleep-apnea-on-carotid-artery-intima-media-thickness-related-to-inflammation
#17
Delei Kong, Zheng Qin, Wei Wang, Jian Kang
PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for atherosclerosis. To ascertain the effect of OSAHS on the development of atherosclerosis in Chinese OSAHS patients, we evaluated markers of atherosclerosis as well as vascular endothelial function and inflammation. METHODS: Chinese men with polysomnography-diagnosed OSAHS were subgrouped into mild-moderate (n = 28) and severe (n = 54) OSAHS groups on the basis of apnea hypopnea index (AHI) scores...
February 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28203016/-efficacy-of-oral-appliance-therapy-of-obstructive-sleep-apnea-and-hypopnea-syndrome-in-different-periods-of-treatment
#18
X Gong, Y Zhao, W R Li, X M Gao
OBJECTIVE: To investigate the long-term efficacy of oral appliance treating of obstructive sleep apnea and hypopnea syndrome (OSAHS) in different periods of treatment. METHODS: A total of 55 patients were included in the study. Patients were all diagnosed with OSAHS by overnight polysomnography and all received oral appliance (OA) as the therapy. The OA positioned the mandible at 60%-70% of the maximal mandible advancement position and created a 4-5 mm incisor separation...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28126502/-therapeutic-alternatives-to-continuous-positive-airway-pressure-for-obstructive-sleep-apnea-hypopnea-syndrome
#19
Frédéric Gagnadoux, Marie Jouvenot, Nicole Meslier, Pascaline Priou, Wocjiech Trzepizur
Oral appliance therapy (OAT) is the main therapeutic alternative to continuous positive airway pressure (CPAP). OAT has been recommended as an appropriate first-line treatment option for moderate obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients without severe cardiovascular comorbidity. The lower efficacy of OAT in reducing sleep-disordered breathing could be offset by a higher compliance relative to CPAP, resulting in similar health outcomes in terms of sleepiness, neurobehavioral functioning, quality of life and blood pressure...
January 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28123665/decrease-of-respiratory-events-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-using-a-mandibular-advancement-device-assessed-with-split-night-polysomnography
#20
Emma García-Campos, Alberto Labra, Lourdes Galicia-Polo, Francisco Sánchez-Narváez, Reyes Haro, Ulises Jiménez, Adrián Poblano
INTRODUCTION: Mandibular advancement device (MAD) may represent a feasible choice in the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS), in well selected patients. OBJECTIVE: The aim of this study is to assess the efficacy of MAD in patients with OSAHS, using split night polysomnography (SNP). METHOD: We performed an auto controlled clinical trial to assess the efficacy of MAD in 30 patients with snoring and OSAHS. Clinical evaluation was made every 2 weeks to adjust treatment and observe changes in clinical symptoms...
July 2016: Sleep Science
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