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https://www.readbyqxmd.com/read/29036248/apremilast-and-narrowband-ultraviolet-b-combination-therapy-for-treating-moderate-to-severe-plaque-psoriasis
#1
Jerry Bagel, Elise Nelson, Brian R Keegan
BACKGROUND: Combining narrowband UVB (NB-UVB) phototherapy with biologics has been shown to enhance the therapeutic response of plaque psoriasis patients. The objective of this study was to evaluate the effectiveness of apremilast combined with NB-UVB in patients with moderate to severe plaque psoriasis. METHODS: This was a 12-week, open-label study of 29 patients diagnosed with moderate to severe psoriasis. Patients received apremilast 30 mg twice daily, and increasing doses of NB-UVB (310-312 nm) 3 times per week for 12 weeks...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29033353/melanocyte-stem-cell-activation-and-translocation-initiate-cutaneous-melanoma-in-response-to-uv-exposure
#2
Hyeongsun Moon, Leanne R Donahue, Eunju Choi, Philip O Scumpia, William E Lowry, Jennifer K Grenier, Jerry Zhu, Andrew C White
Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor initiation remain unclear. The majority of melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melanomas can arise from melanocyte stem cells (MCSCs). Here we employ mouse models to define the role of MCSCs as melanoma cells of origin, demonstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic environmental and molecular factors required for the critical early steps of melanoma initiation...
October 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29031211/cyanidin-3-o-glucoside-inhibits-the-uvb-induced-ros-cox-2-pathway-in-hacat-cells
#3
Yong He, Yunfeng Hu, Xinwei Jiang, Tianfeng Chen, Yuetang Ma, Shi Wu, Jianxia Sun, Rui Jiao, Xiaoling Li, Liehua Deng, Weibin Bai
Ultraviolet (UV) radiation from sunlight, especially UVB (290-320nm), is one of the most important environmental factors that destroys the integrity of the skin and causes epidermal cell apoptosis, potentially even leading to skin cancer. UVB irradiation can cause skin damage by stimulating inflammatory and apoptotic pathways. Anthocyanins are flavonoids that are common in many vegetable foods, and have also demonstrated chemopreventive effects. Cyanidin-3-O-glucoside, as a typical anthocyanin, exhibits anti-inflammatory and anti-oxidant effects...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29029903/folate-and-phototherapy-what-should-we-inform-our-patients
#4
REVIEW
Myron Zhang, Gregory Goyert, Henry W Lim
BACKGROUND: Ultraviolet (UV) degradation of folate has been studied in vitro and in vivo, but comprehensive reviews of the subject and recommendations for supplementing folate are lacking, especially for women of childbearing age, in whom decreases in folate predisposes newborns to neural tube defects. OBJECTIVE: We reviewed the effects of phototherapy on folate and provide a recommendation for women of childbearing age on phototherapy. METHODS: PubMed was searched for in vivo studies comparing folate levels before and after phototherapy...
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29021691/photoprotective-effects-of-topical-ginseng-leaf-extract-using-ultraflo-l-against-uvb-induced-skin-damage-in-hairless-mice
#5
Yang Hee Hong, Hyun-Sun Lee, Eun Young Jung, Sung-Hee Han, Yooheon Park, Hyung Joo Suh
BACKGROUND: Abnormal activation of matrix metalloproteinases (MMPs) plays an important role in UV-induced wrinkle formation, which is a major dermatological problem. This formation occurs due to the degeneration of the extracellular matrix (ECM). In this study, we investigated the cutaneous photoprotective effects of Ultraflo L treated ginseng leaf (UTGL) in hairless mice. METHODS: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29017858/the-transcriptional-response-of-skin-to-fluorescent-light-exposure-in-viviparous-xiphophorus-and-oviparous-danio-oryzias-fishes
#6
Mikki Boswell, William Boswell, Yuan Lu, Markita Savage, Zachary Mazurek, Jordan Chang, Jeanot Muster, Ronald Walter
Differences in light sources are common in animal facilities and potentially can impact experimental results. Here, the potential impact of lighting differences on skin transcriptomes has been tested in three aquatic animal models commonly utilized in biomedical research, (Xiphophorus maculatus (platyfish), Oryzias latipes (medaka) and Danio rerio (zebrafish). Analysis of replicate comparative RNASeq data showed the transcriptional response to commonly utilized 4100K or "cool white" fluorescent light (FL) is much greater in platyfish and medaka than in zebrafish...
October 7, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28994699/fisetin-regulates-nrf2-expression-and-the-inflammation-related-signaling-pathway-to-prevent-uvb-induced-skin-damage-in-hairless-mice
#7
Po-Yuan Wu, Jia-Ling Lyu, Yi-Jung Liu, Ting-Yi Chien, Hao-Cheng Hsu, Kuo-Ching Wen, Hsiu-Mei Chiang
Chronic ultraviolet (UV) exposure may cause skin damage, disrupt skin barrier function, and promote wrinkle formation. UV induces oxidative stress and inflammation, which results in extracellular matrix degradation in the dermis and epidermal hyperplasia. Our previous study demonstrated that fisetin exerts photoprotective activity by inhibiting mitogen-activated protein kinase/activator protein-1/matrix metalloproteinases (MMPs) activation. In this study, fisetin was applied topically to investigate its antiphotodamage effects in hairless mice...
October 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28990310/the-interaction-between-vitamin-d-receptor-polymorphisms-and-sun-exposure-around-time-of-diagnosis-influences-melanoma-survival
#8
Irene Orlow, Yang Shi, Peter A Kanetsky, Nancy E Thomas, Li Luo, Sergio Corrales Guerrero, Anne E Cust, Lidia Sacchetto, Roberto Zanetti, Stefano Rosso, Bruce K Armstrong, Terence Dwyer, Alison Venn, Richard P Gallagher, Stephen B Gruber, Loraine D Marrett, Hoda Anton-Culver, Klaus Busam, Colin B Begg, Marianne Berwick
Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma-death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3' end haplotype were significant (p<0.05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models, and exerted their effect in the opposite direction among those with low UVB...
October 9, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28990056/arctiin-regulates-collagen-type-1%C3%AE-chain-1-mrna-expression-in-human-dermal-fibroblasts-via-the-mir%C3%A2-378b%C3%A2-sirt6-axis
#9
Karam Kim, Sungkwan An, Byung Gon Choi, Dahye Joo, Young Min Choi, Kyu Joong Ahn, In-Sook An, Hwa Jun Cha
Arctiin, a lignin isolated from Arctium lappa, exhibits a variety of biological effects, including anti‑viral, anti‑inflammatory, and anti‑proliferative actions, in mammalian cells. In a previous study, arctiin was demonstrated to induce procollagen type I synthesis and exhibited protective effects against ultraviolet B (UVB) radiation in normal human dermal fibroblasts (nHDFs). However, the underlying molecular mechanism of arctiin‑mediated collagen synthesis remains unknown. In the present study, the mechanism for increased expression of collagen type 1α 1 chain (COL1A1) mRNA in arctiin‑induced nHDFs was identified...
October 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988108/salubrinal-protects-human-skin-fibroblasts-against-uvb-induced-cell-death-by-blocking-endoplasmic-reticulum-er-stress-and-regulating-calcium-homeostasis
#10
Chao Ji, Bo Yang, Shu-Ying Huang, Jin-Wen Huang, Bo Cheng
The role of UVB in skin photo damages has been widely reported. Overexposure to UVB will induce severe DNA damages in epidermal cells and cause most cytotoxic symptoms. In the present study, we tested the potential activity of salubrinal, a selective inhibitor of Eukaryotic Initiation Factor 2 (eIF2) -alpha phosphatase, against UV-induced skin cell damages. We first exposed human fibroblasts to UVB radiation and evaluated the cytosolic Ca(2+) level as well as the induction of ER stress. We found that UVB radiation induced the depletion of ER Ca(2+) and increased the expression of ER stress marker including phosphorylated PERK, CHOP, and phosphorylated IRE1α...
October 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28984923/b-cell-tolerance-to-epidermal-ribonuclear-associated-neo-autoantigen-in-vivo
#11
Søren E Degn, Elisabeth Alicot, Michael C Carroll
Defining how self-antigens are perceived by the immune system is pivotal to understand how tolerance is maintained under homeostatic conditions. Clinically relevant, natural autoantigens targeted by autoantibodies in e.g. systemic lupus erythematosus (SLE) commonly have an intrinsic ability to engage not only the B cell receptor (BCR), but also a costimulatory pathway in B cells, such as the TLR7 pathway. Here we developed a novel mouse model displaying inducible expression of a fluorescent epidermal neo-autoantigen carrying an OT-II T cell epitope, B cell antigen, and associated ribonucleic acids capable of stimulating TLR7...
October 6, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28983623/microrna%C3%A2-378b-regulates-%C3%AE-%C3%A2-1%C3%A2-type-1-collagen-expression-via-sirtuin-6-interference
#12
Dahye Joo, Sungkwan An, Byung Gon Choi, Karam Kim, Young Min Choi, Kyu Joong Ahn, In-Sook An, Hwa Jun Cha
Ultraviolet (UV) light mediates skin aging and induces destruction of the dermis by modulating the expression levels of extracellular matrix‑associated genes, including collagen and matrix metalloproteinases. Sirtuin 6 (SIRT6), a member of the sirtuin family of proteins, regulates collagen metabolism and is an established anti‑aging protein. However, the exact underlying mechanism by which SIRT6 expression is regulated in dermal fibroblasts during the aging process is unclear. The present study demonstrated that expression of microRNA‑378b (miR‑378b) is induced in UVB‑exposed human dermal fibroblasts (HDFs), and this was inversely associated with the mRNA expression levels of α‑1‑type 1 collagen (COL1A1)...
September 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28981670/antioxidant-protection-by-astaxanthin-in-the-citrus-red-mite-acari-tetranychidae
#13
Makoto Atarashi, Yuki Manabe, Hidenari Kishimoto, Tatsuya Sugawara, Masahiro Osakabe
Solar ultraviolet-B (UVB) radiation and radiant heat have lethal effects on plant-dwelling mites, including spider mites, and their natural enemies, such as phytoseiid mites, leading them to reside on lower leaf surfaces. Panonychus spider mites are outcompeted by Tetranychus spider mites and thus exploit upper leaf surfaces, where they are exposed to both UVB radiation and radiant heat. Panonychus spider mites are thought to produce astaxanthin constitutionally. In this study, we compared carotenoid components, antioxidant capacity, lipid peroxidation, survival, and egg production in wild-type (WTS) and albino-type strains (ATS) of Panonychus citri (McGregor)...
July 8, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28978033/mysm1-2a-dub-is-an-epigenetic-regulator-in-human-melanoma-and-contributes-to-tumor-cell-growth
#14
Christina Wilms, Carsten M Kroeger, Adelheid V Hainzl, Ishani Banik, Clara Bruno, Ioanna Krikki, Vida Farsam, Meinhard Wlaschek, Martina V Gatzka
Histone modifying enzymes, such as histone deacetylases (HDACs) and polycomb repressive complex (PRC) components, have been implicated in regulating tumor growth, epithelial-mesenchymal transition, tumor stem cell maintenance, or repression of tumor suppressor genes - and may be promising targets for combination therapies of melanoma and other cancers. According to recent findings, the histone H2A deubiquitinase 2A-DUB/Mysm1 interacts with the p53-axis in hematopoiesis and tissue differentiation in mice, in part by modulating DNA-damage responses in stem cell and progenitor compartments...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977801/mir-26a-mediates-ultraviolet-b-induced-apoptosis-by-targeting-histone-methyltransferase-ezh2-depending-on-myc-expression
#15
Ting Zhang, Hua Qian, Cui Hu, Hui Lu, Ji-Bing Li, Ya-Fen Wu, Wei Li
BACKGROUND/AIMS: Ultraviolet B (UVB) damage is the most essential etiological factor in skin carcinogenesis, and apoptosis leads to the efficient elimination of UVB-damaged cells. However, the mechanisms underlying resistance to UVB-induced apoptosis remain unclear. METHODS: HaCaT and A431 cells were used in the present study. Quantitative real-time PCR, single cell PCR, and western blotting were used to examine cancer-related gene expression at the mRNA and protein levels...
October 5, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28977677/signaling-cascades-activated-by-uvb-in-human-melanocytes-lead-to-the-increased-expression-of-melanocyte-receptors-endothelin-b-receptor-and-c-kit-%C3%A2
#16
Shuko Terazawa, Genji Imokawa
A single exposure of normal human melanocytes (NHMs) to ultraviolet B (UVB) radiation induces a distinct increase in the expression of c-KIT and endothelin B receptor (EDNRB) and up-regulates the expression of microphthalmia-associated transcription factor (MITF). In this review, we clarify the signaling mechanisms by which UVB stimulates the expression of MITF in NHMs, thus leading to up-regulation of those two important melanogenic receptors. The increased expression of MITF in UVB-exposed NHMs is accompanied by a markedly stimulated and prolonged phosphorylation of p38/CREB...
October 4, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28975707/skin-penetration-and-uv-damage-prevention-by-nanoberries
#17
Paula Bucci, María Jimena Prieto, Laura Milla, María Natalia Calienni, Luis Martinez, Viviana Rivarola, Silvia Alonso, Jorge Montanari
BACKGROUND: Ethanolic extract from blueberry (Vaccinium myrtillus) is rich in anthocyanins and thus exhibits antioxidant activity. On the other hand, ultradeformable liposomes are capable of penetrating to the impermeable barrier of skin. Nanoberries are ultradeformable liposomes carrying blueberry extract. OBJECTIVES: In this study, their capacity to penetrate the stratum corneum and photodamage prevention were tested, with the aim of developing a topical formulation for skin protection from environmental damage...
October 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28965926/exposure-to-4100k-fluorescent-light-elicits-sex-specific-transcriptional-responses-in-xiphophorus-maculatus-skin
#18
William T Boswell, Mikki Boswell, Dylan J Walter, Kaela L Navarro, Jordan Chang, Yuan Lu, Markita G Savage, Jianjun Shen, Ronald B Walter
It has been reported that exposure to artificial light may affect oxygen intake, heart rate, absorption of vitamins and minerals, and behavioral responses in humans. We have reported specific gene expression responses in the skin of Xiphophorus fish after exposure to ultraviolet light (UV), as well as, both broad spectrum and narrow waveband visible light. In regard to fluorescent light (FL), we have shown that male X. maculatus exposed to 4100K FL (i.e. "cool white") rapidly suppress transcription of many genes involved with DNA replication and repair, chromosomal segregation, and cell cycle progression in skin...
September 28, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28965841/corrigendum-to-topical-application-of-neem-leaves-prevents-wrinkles-formation-in-uvb-exposed-hairless-mice-j-photochem-photobiol-b-biol-169-april-2017-161-170
#19
Hien T T Ngo, Eunson Hwang, Seul-A Seo, Bom Park, Zheng-Wang Sun, Mengyang Zhang, Yu-Kyong Shin, Tae-Hoo Yi
No abstract text is available yet for this article.
September 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28965564/concentration-of-selenium-zinc-copper-cu-zn-ratio-total-antioxidant-status-and-c-reactive-protein-in-the-serum-of-patients-with-psoriasis-treated-by-narrow-band-ultraviolet-b-phototherapy-a-case-control-study
#20
Marta Wacewicz, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Piotr Aleksiejczuk, Jolanta Ostrowska, Maria H Borawska
BACKGROUND: Psoriasis is a common, an inflammatory skin disease. Trace elements may play an active role in the pathogenesis of psoriasis. OBJECTIVE: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) and c-reactive protein (CRP) in the serum of patients with psoriasis. METHODS: In this case-control study sixty patients with psoriasis and fifty-eight healthy people were examined...
December 2017: Journal of Trace Elements in Medicine and Biology
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