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A Zheleva, G Nikolova, Y Karamalakova, E Hristakieva, R Lavcheva, V Gadjeva
Currently accepted that oxidative stress is a triggering event in the melanocytic destruction and is probably involved in the etiopathogenesis of vitiligo disease. Despite numerous investigations, contradictory results were reported about the levels of oxidative stress biomarkers measured in the skin and blood of vitiligo patients. By Electron Paramagnetic Resonance spectroscopy (EPR) and spectrophotometry, we have investigated and compared some oxidative stress biomarkers in the blood of vitiligo patients' before and after UVB Narrow Band 311 nm phototherapy combined with the antioxidant nutritional supplement containing - Vitamin C, Vitamin B1, L -Cysteine, Lipoic Acid, and polyunsaturated fatty acids...
February 14, 2018: Regulatory Toxicology and Pharmacology: RTP
Abhendra K Singh, Heath E Misak, Shankar Mall
The effects of ultraviolet B (UVB) exposure on the tensile behavior of CNT sheet was investigated in this study. Two types of CNT sheet, one acid treated and one un-treated, were directly exposed to UVB light for 500 hours. The exposure was done using a UVB lamp inside a dark chamber under room temperature ambient condition. The microstructure of the CNT sheets were studied both prior to and after UVB exposure using a scanning electron microscope. Upon completion of the exposure duration, the CNT sheet test coupons were tested mechanically in tension using a microtester to evaluate the tensile strength and behavior...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Marie-Catherine Drigeard Desgarnier, Patrick J Rochette
Absorption of solar ultraviolet (UV) radiation by DNA leads to the formation of the highly mutagenic cyclobutane pyrimidine dimer (CPD). The mutagenicity of CPD is caused, in part, by the fact that their recognition and repair by the nucleotide excision repair (NER) pathway is challenging and slow. It has been previously shown that a pre-stimulation with genotoxic agents improve NER efficiency of CPD, indicating a potential adaptive response of this repair pathway. We have pre-treated human dermal fibroblasts with repeated subletal low doses of UVB (chronic low-dose of UVB; CLUV) to determine whether it could enhance NER capacity to repair CPD...
January 31, 2018: DNA Repair
Wei Gao, Yu-Shuai Wang, Zheng-Yi Qu, Eunson Hwang, Hien T T Ngo, Ying-Ping Wang, Jahyun Bae, Tae-Hoo Yi
UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents have become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs)...
February 15, 2018: Photochemistry and Photobiology
Seema Sharma, Davindar Parsad, Rajsmita Bhattacharjee, Sendhil Kumaran Muthu
The treatment of vitiligo has been a tough challenge for dermatologists. Phototherapy, apart from being first line monotherapy,1has also been used in combination with topical therapies like corticosteroids, khellin, phenylalanine, calcineurin inhibitors etc, with the aim of hastening and enhancing repigmentation and reducing side-effects.2,3Recent reports have highlighted darkening of iris, and eyelash and periocular hyperpigmentation induced by latanoprost (prostaglandin F2α analogue) used for treatment of glaucoma...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Yanna Cao, Ling Gao, Renhong Tang, Wenhua Zhang
AIM: Glaucoma is a universal eye disease which is commonly associated with increased intraocular pressure caused by impaired aqueous humor (AH) drainage. This study aimed to investigate the effects of Hsp70 on trabecular meshwork (TM) injury induced by UVB. METHODS: Real-time quantitative PCR (qRT-PCR) was used to examine the mRNA levels of Hsp70. siRNA was used to downregulate Hsp70 expression in the TM cells to inspect changes in cell proliferation and apoptosis...
June 1, 2017: Die Pharmazie
A H Prado, M C Borges, J O Eloy, R G Peccinini, M Chorilli
Cutaneous penetration is a critical factor in the use of sunscreen, as the compounds should not reach systemic circulation in order to avoid the induction of toxicity. The evaluation of the skin penetration and permeation of the UVB filter octyl methoxycinnamate (OMC) is essential for the development of a successful sunscreen formulation. Liquid-crystalline systems are innovative and potential carriers of OMC, which possess several advantages, including controlled release and protection of the filter from degradation...
October 1, 2017: Die Pharmazie
Inhyuk Yeo, Yong-Jik Lee, Kyeongseop Song, Hyeon-Su Jin, Jae-Eun Lee, Dajeong Kim, Dong-Woo Lee, Nam Joo Kang
Bioactive peptides contribute to various cellular processes including improved skin physiology. Hence, bioactive keratins have attracted considerable attention as active cosmetic ingredients for skin health. Here, we obtained low molecular weight (LMW) keratins from native chicken feathers by anaerobic digestion with an extremely thermophilic bacterium Fervidobacterium islandicum AW-1, followed by stepwise fractionation through ultrafiltration. To assess the effects of the feather keratins on skin health, we performed in vitro and ex vivo assays to investigate their inhibitory effects on matrix metalloproteinases (MMPs)...
February 10, 2018: Journal of Biotechnology
Nitesh Shirsath, Karin Wagner, Simone Roos, Michaela Schlederer, Christian Ringel, Lukas Kenner, Bernhard Brüne, Peter Wolf
The effects of 8-methoxypsoralen plus ultraviolet A (PUVA) and ultraviolet B (UVB) on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and psoriasis through the application of imiquimod. PUVA, to a greater degree than UVB, suppressed the established imiquimod-induced psoriatic phenotype, but pretreatment with PUVA prior to administration of imiquimod also reduced the susceptibility of murine skin to respond to imiquimod to a greater degree than did UVB...
February 13, 2018: Acta Dermato-venereologica
Yin Jia, Qin Qin, Chao-Ping Fang, Wei Shen, Ting-Ting Sun, Yuan-Lan Huang, Wen-Jie Li, An-Mei Deng
The aim of the current study was to understand the mechanisms of apoptosis occurring in cultured human lens epithelial cells (HLECs) following ultraviolet B (UVB) irradiation. The investigations intended to confirm the presence of apoptosis and to reveal the roles of oxidative stress, calcium (Ca2+), c‑Jun NH2‑terminal kinase (JNK)1/2, and extracellular signal‑regulated kinase (ERK)1/2 signaling pathway in these progresses. Cell apoptosis, ROS generation and intracellular Ca2+ concentration was measured by flow cytometry...
February 9, 2018: International Journal of Molecular Medicine
Eunson Hwang, Hien T T Ngo, Seul A Seo, Bom Park, Mengyang Zhang, Tae-Hoo Yi
BACKGROUND: Alchemilla mollis (lady's mantle) is a common ingredient in skin care products. However, the protective mechanism of A. mollis against skin problems has not been elucidated. PURPOSE: This study was to investigate the effects of A. mollis ethanolic extract (AM) on UVB-irradiated normal human dermal fibroblasts (NHDF) and hairless mice. METHODS: The in vitro anti-photoaging effect of AM was performed in NHDFs. The antioxidant activities were assessed through DPPH, ABTS, and reactive oxygen species (ROS) assays...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Tetsuya Kuwano, Sawako Kawano, Daiji Kagawa, Yuka Yasuda, Yosuke Inoue, Takatoshi Murase
Skin properties are influenced by both external (e.g., ultraviolet [UV], chemicals, and bacteria) and internal factors (e.g., nutrition and hormones). Therefore, some dietary supplements are expected to improve skin conditions. Glucono-δ-lactone (GDL) is widely used as a food additive and is naturally present in wine, honey, and other foods. The aim of this study was to assess whether GDL improves skin condition and inflammation. In a double-blind, placebo-controlled study, 40 healthy Japanese male volunteers were randomly assigned to either the GDL (2000 mg day-1) or placebo group...
February 12, 2018: Food & Function
A Lesiak, D Sobolewska-Sztychny, I A Bednarski, K Wódz, M Sobjanek, A Woźniacka, J Narbutt
BACKGROUND: There is still much ambiguity in studies of Sonic hedgehog (Shh) pathways and its dysregulation. Some studies concerning the role of the Shh pathway in basal cell carcinoma (BCC) have been conducted, but there is a lack of studies about Shh pathway dysregulation under the influence of ultraviolet (UV)B radiation. AIM: To evaluate skin expression of Shh, Ptch1, Ptch2, Smo and Gli1 proteins in BCCs with and without the influence of UVB radiation. METHODS: In total, 34 healthy controls (HCs) and 42 patients with nodular BCC were recruited into the study...
February 9, 2018: Clinical and Experimental Dermatology
Zsuzsanna Ujfaludi, Agota Tuzesi, Hajnalka Majoros, Balint Rothler, Tibor Pankotai, Imre M Boros
Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, we use a novel human keratinocyte model, HKerE6SFM, to demonstrate that UVB activates the transcription of most members of the 11q22.3 MMP gene cluster including MMP13, MMP12, MMP3, MMP1 and MMP10...
February 8, 2018: Scientific Reports
Lu Li, Eunson Hwang, Hien T T Ngo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi
Cherry blossoms have attracted attention as an ingredient with potential for use in skincare products. However, no skin photoaging-related research has been performed with this plant. In the present study, cherry blossom extract (CBE) at 1, 10, and 100 μg/mL was investigated for its skin anti-photoaging effects in UVB-irradiated normal human dermal fibroblasts (NHDF) cells in vitro. Our results showed that CBE markedly increased type I procollagen during UVB exposure via two pathways. Firstly, transcription activator protein-1 expression and MAP kinases were downregulated, consequently reducing the production of matrix metalloproteinase (MMP)-1 and MMP-3...
February 8, 2018: Photochemistry and Photobiology
Yue-Hui Wang, Cheng-Kuan Sun, Xiang-Lan Li, Yan Huang, Jing Sun
Persistent exposure to solar ultraviolet radiation (UVR) causes continuous damages to skin, including progressive impairment of epidermal stem cells (ESCs) capacities. Ghrelin is the only known endogenous orexigenic hormone, which has displayed its various pharmacological functions. In the current study, we found that the specific receptor of ghrelin, growth hormone secretagogue receptor (GHS-R), is expressed in ESCs. Interestingly, GHS-R expression is significantly upregulated in response to ultraviolet B (UVB) radiation...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Adam Barlev, Dipankar Sen
Photochemical modification is the major class of environmental damage suffered by DNA, the genetic material of all free-living organisms. Photolyases are enzymes that carry out direct photochemical repair (photoreactivation) of covalent pyrimidine dimers formed in DNA from exposure to ultraviolet light. The discovery of catalytic RNAs in the 1980s led to the "RNA world hypothesis", which posits that early in evolution RNA or a similar polymer served both genetic and catalytic functions. Intrigued by the RNA world hypothesis, we set out to test whether a catalytic RNA (or a surrogate, a catalytic DNA) with photolyase activity could be contemplated...
February 8, 2018: Accounts of Chemical Research
Chen Lu, Jillian E Smith-Carpenter, John-Stephen A Taylor
UVB irradiation of human telomeric (GGGTTA)3 GGG sequences in potassium ion solution crosslinks the first and third TTA segments through anti cyclobutane pyrimidine dimer (CPD) formation. The photocrosslinking reaction was first proposed to occur through a form 3 two tetrad G-quadruplex in which the lateral 4-nucleotide GTTA loop can interact with an adjacent TTA loop. Curiously, the reaction does not occur with sodium ion, which was explained by the formation of a basket structure which only has 3-nucleotide TTA loops that cannot interact...
February 8, 2018: Photochemistry and Photobiology
Edris Hoseinzadeh, Parisa Taha, Chiang Wei, Hatam Godini, Ghulam Md Ashraf, Mahmoud Taghavi, Mohammad Miri
Vitamin D (VD) is an important nutrient for preventing several chronic diseases, and vitamin D deficiency (VDD) causes many diseases. Air pollution has been reported as one of the most significant factors that causes VDD. Some epidemiological studies have evaluated VDD prevalence, and presented air pollution as a potential cause of VDD. In addition, recent case studies have found that VDD is associated with air pollutants. Nearly all reports agree that air pollution affects VD levels by reducing sun exposure, especially UVB radiation...
February 1, 2018: Food and Chemical Toxicology
Hjalte H Andersen, Silvia Lo Vecchio, Jesper Elberling, Gil Yosipovitch, Lars Arendt-Nielsen
Exaggerated itch responses to pruritic chemical provocations and mechanical stimuli are evident in patients with chronic itch, e.g., in atopic dermatitis. Currently used human models of itch do not account for such itch sensitization features and the mechanisms underlying clinical itch sensitization are unknown. This study utilized two established human models of cutaneous nociceptive sensitization to explore how pre-established inflammatory hyperalgesia (ultraviolet-B-irradiation; 'UVB') and non-inflammatory neurotrophic pain sensitization (nerve growth factor; 'NGF') alter sensitivity to chemical and mechanically-evoked itch...
February 6, 2018: Experimental Dermatology
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