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https://www.readbyqxmd.com/read/29689290/multigenerational-effects-of-maternal-cigarette-smoke-exposure-during-pregnancy-on-sperm-counts-of-f1-and-f2-male-offspring
#1
Hye Jeong Lee, Na Young Choi, Yo Seph Park, Seung-Won Lee, Jin Seok Bang, Yukyeong Lee, Jae-Sung Ryu, Seong-Jin Choi, Sang-Hyub Lee, Gwang Soo Kim, Hyun Woo Chung, Kisung Ko, Kyuhong Lee, Kinarm Ko
Animal models and human studies showed that in utero cigarette smoke exposure decreases sperm counts of offspring. This study used a mouse model to investigate the effects of maternal exposure to cigarette smoke on reproductive systems in F1 and F2 male offspring. Female ICR mice were exposed either to clean air or to cigarette smoke during pregnancy at the post-implantation stage. Epididymal sperm counts were decreased in a cigarette smoke dose-dependent manner in F1 (by 40-60%) and F2 males (by 23-40%) at postnatal day 56...
April 21, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29685852/assessment-of-antimicrobiral-prophylaxis-in-transperineal-prostate-biopsy-a-single-center-retrospective-study-of-485-cases
#2
Kyoko Baba, Yoshitaka Sekine, Yoshiyuki Miyazawa, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
To verify the validity of our antimicrobial prophylaxis regimen for transperineal prostate biopsies, we investigated the rate of infectious complications in this procedure. We retrospectively investigated the infectious complications in 485 patients who underwent a transperineal prostate biopsy between 2014 and 2016 at our hospital. In the clinic, we use cefazolin (CEZ) for antimicrobial prophylaxis. Infectious complications were assessed up to postoperative day (POD) 30. Patients with infectious complications were further investigated to determine the site of infection, outbreak day, and type of pathogenic bacteria...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29681853/caffeine-promotes-conversion-of-palmitic-acid-to-palmitoleic-acid-by-inducing-expression-of-fat-5-in-caenorhabditis-elegans-and-scd1-in-mice
#3
Xiaocui Du, Qin Huang, Yun Guan, Ming Lv, Xiaofang He, Chongye Fang, Xuanjun Wang, Jun Sheng
The synthesis and metabolism of fatty acids in an organism is related to many biological processes and is involved in several diseases. The effects of caffeine on fatty acid synthesis and fat storage in Caenorhabditis elegans and mice were studied. After 6 h of food deprivation, adult C. elegans were treated with 0.1 mg/mL caffeine for 24 h. Quantitative reverse-transcription polymerase chain reaction showed that, among all the genes involved in fat accumulation, the mRNA expression of fat-5 in caffeine-treated C...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29679169/the-utility-of-scrotal-ultrasonography-in-the-emergent-setting-beyond-epididymitis-versus-torsion
#4
Christopher R McAdams, Andrew J Del Gaizo
Scrotal pain is a common acute presentation for medical care. Testicular torsion and epididymo-orchitis are two diagnoses for which early detection is critical and their sonographic imaging features have been thoroughly described in the radiologic literature. Other important conditions for which radiologists must be aware have received less attention. This article will highlight key traumatic and non-traumatic causes of acute scrotal pain other than testicular torsion and epididymo-orchitis that may present in the emergency department setting...
April 21, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29678877/deferoxamine-ameliorates-adipocyte-dysfunction-by-modulating-iron-metabolism-in-ob-ob-mice
#5
Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan, Chuang Guo
OBJECTIVE: The mechanisms underlying obesity and anti-obesity processes have garnered remarkable attention as potential therapeutic targets for obesity-associated metabolic syndromes. Our prior work has shown the healing efficacy of iron reduction therapies for hepatic steatosis in a rodent model of diabetes and obesity. In this study, we investigated how iron depletion by deferoxamine (DFO) affected adipocyte dysfunction in the epididymal adipose tissues of ob/ob mice. METHODS: Male ob/ob mice were assigned to either a vehicle-treated or DFO-treated group...
April 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29676547/morphologic-comparison-of-peripheral-nerves-in-adipocyte-tissue-from-db-db-diabetic-versus-normal-mice
#6
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control mice were used. Epididymal adipose tissue from diabetic db/db mice with that from control heterozygous db/m mice was compared using confocal microscopy-based method to visualize intact whole adipose tissue. Immunohistochemistry with tyrosine hydroxylase for sympathetic (SP), choline acetyltransferase for parasympathetic (PSP), and protein gene product 9...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29675927/tributyltin-reduces-the-levels-of-serum-adiponectin-and-activity-of-akt-and-induces-metabolic-syndrome-in-male-mice
#7
Haotian Yan, Hao Guo, Dong Cheng, Ruirui Kou, Cuili Zhang, Jiliang Si
Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor-γ (PPARγ). However, the adverse effects of TBT on metabolism are incompletely understood. In this study, male ICR mice were administered TBT (5 and 50 μg·kg- 1 ) by an intraperitoneal injection once every 3 days for 30 days from 28 days of age and bred for another 30 days after the last administration of TBT. We analyzed the effects of these exposures on the fat depot weights, serum lipid profile, serum leptin and adiponectin, hepatic lipid accumulation, and activity of AKT in the liver and skeletal muscle isolated from mice 8 mins after receiving an insulin injection...
April 20, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29674266/effects-of-high-protein-diet-containing-isolated-whey-protein-in-rats-submitted-to-resistance-training-of-aquatic-jumps
#8
Eudes Thiago Pereira Avila, Thiago da Rosa Lima, Ramires Alsamir Tibana, Paula Caroline de Almeida, Géssica Alves Fraga, Mariana de Souza Sena, Luiz Felipe Petusk Corona, James Wilfred Navalta, Sajjad Rezaei, Morteza Ghayomzadeh, Amílcar Sabino Damazo, Jonato Prestes, Fabrício Azevedo Voltarelli
OBJECTIVES: Isolated whey protein (IWP) can decrease body fat compared with other protein sources. The present study verified the effects of high protein diet (HD) containing IWP on several parameters of rats subjected to resistance training (RT). METHODS: Thirty-two male Wistar rats (60 days of age) were separated into four groups (n = 8/group): sedentary normoproteic (IWP 14%; SN); sedentary hyperproteic (IWP 35%; SH); trained normoproteic (IWP 14%; TN), and trained hyperproteic (WPI 35%; TH)...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29668706/different-managements-for-prepubertal-epididymitis-based-on-a-preexisting-genitourinary-anomaly-diagnosis
#9
Yong Seung Lee, Sang Woon Kim, Sang Won Han
There is no clear consensus regarding investigating for accompanying genitourinary anomalies (GUAs) in patients with prepubertal acute epididymitis (AE). Moreover, risk factors for the recurrence and the need for a surgical intervention have never been discussed. The purpose of this study was to evaluate the different clinical courses of prepubertal AE based on knowledge of preexisting GUAs. Between January 2005 and December 2014, AE was diagnosed in 189 pediatric patients <10 years old. Clinical characteristics and treatments were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29668338/morphometric-and-ultrastructural-analysis-of-tramadol-effects-on-epididymis-an-experimental-study
#10
Abdalla Mohamed Attia, Ola Ahmed Bakry, Hossam Yassin, Naglaa Sarhan, Rehab Samaka, Nahla Gamal
The effect of tramadol addiction on epididymal structure was not investigated before. Therefore, this experimental study was carried out to investigate the effect of chronic tramadol use on the epididymal structure using light and electron microscopies. Thirty adult Wister Albino male rats were divided into two groups: control group (five rats) and tramadol-treated group (25 rats), which was further subdivided into five subgroups that received tramadol orally at 4.5, 9, 45, 90, and 135 mg/kg/day, respectively, for 18 weeks...
April 18, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29663943/retrospective-review-of-surgical-outcomes-and-pair-housing-success-in-vasectomized-rhesus-macaques-macaca-mulatta
#11
Dilrukshi K Ekanayake-Alper, Steven R Wilson, Jodi A Scholz
Providing social housing for adult male macaques can be challenging. One successful strategy for long-term social housing of adult male macaques is to pair them with adult females; however, unwanted breeding must be prevented by sterilization of the male or female. Vasectomy is a simple, highly effective, and minimally invasive method of contraception that is used at our institution to facilitate social housing. We performed a retrospective review to analyze the surgical outcomes and rate of postoperative complications after vasectomy of adult rhesus macaques at our research facility...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29660630/anti-apoptotic-effects-of-minocycline-on-ram-epididymal-spermatozoa-exposed-to-oxidative-stress
#12
Zahra Merati, Abbas Farshad, Amjad Farzinpour, Jalal Rostamzadeh, Mohsen Sharafi
Cryopreservation causes major damage to sperm cells and thereby, increased apoptosis has been documented as physiologically programmed cells death. The goal of current study was to evaluate the anti-apoptotic effects of minocycline compared to sericin added to diluents on frozen-thawed spermatozoa. Epididymal spermatozoa isolated from 50 pairs testes with motility >80% and total morphological abnormalities <10% were pooled, divided into 9 aliquots and used for cryopreservation. The semen samples were re-suspended with basic Tris egg yolk diluent containing minocycline (5 and 10 mg) and tert-butyl hydro peroxide (10 and 20 μm) and sericin (0...
April 6, 2018: Theriogenology
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#13
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652550/chia-seed-supplementation-reduces-senescence-markers-in-epididymal-adipose-tissue-of-high-fat-diet-fed-samp8-mice
#14
Yehua Rui, Shengyi Yang, Li-Hua Chen, Li-Qiang Qin, Zhongxiao Wan
Adipose tissue is a key organ with substantial senescent cell accumulation under both obesity and aging conditions. Chia seed is an ancient seed and is the richest plant source of α-linolenic acid. We aimed to determine how cellular senescence markers will be altered in adipose tissue of senescence-accelerated mouse-prone 8 (SAMP8) mice fed with high-fat diets (HFDs); and how chia seed can affect the above markers. SAMP8 mice and their control senescence-accelerated mouse-resistant 1 (SAMR1) were divided into four groups, that is, SAMR1 low-fat diet group (R1LF), SAMP8LF group (P8LF), SAMP8 high-fat group (P8HF), and SAMP8HF group supplemented with 10% chia seed (P8HC)...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29649530/self-assembled-hyaluronic-acid-nanoparticles-implications-as-a-nanomedicine-for-treatment-of-type-2-diabetes
#15
Jun Gi Rho, Hwa Seung Han, Ji Hye Han, Hansang Lee, Van Quy Nguyen, Wang Hee Lee, Seunglee Kwon, Sungeun Heo, Juhwan Yoon, Han Ho Shin, Eun-Young Lee, Hoin Kang, Siyoung Yang, Eun Kyung Lee, Jae Hyung Park, Wook Kim
Self-assembled hyaluronic acid nanoparticles (HA-NPs) have been extensively investigated for biomedical and pharmaceutical applications owing to their biocompatibility and receptor-binding properties. Here, we report that an empty HA-NP itself not bearing any drug has therapeutic effects on adipose tissue inflammation and insulin resistance. HA-NPs inhibited not only the receptor-mediated internalization of low-molecular-weight (LMW) free HA but also LMW free HA-induced pro-inflammatory gene expression in mouse primary bone marrow-derived macrophages (BMDMs) isolated from wild-type mice, but not in CD44-null (CD44-/-) BMDMs...
April 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29648649/infectious-inflammatory-and-autoimmune-male-factor-infertility-how-do-rodent-models-inform-clinical-practice
#16
Monika Fijak, Adrian Pilatz, Mark P Hedger, Nour Nicolas, Sudhanshu Bhushan, Vera Michel, Kenneth S K Tung, Hans-Christian Schuppe, Andreas Meinhardt
BACKGROUND: Infection and inflammation of the reproductive tract are significant causes of male factor infertility. Ascending infections caused by sexually transmitted bacteria or urinary tract pathogens represent the most frequent aetiology of epididymo-orchitis, but viral, haematogenous dissemination is also a contributory factor. Limitations in adequate diagnosis and therapy reflect an obvious need for further understanding of human epididymal and testicular immunopathologies and their contribution to infertility...
April 10, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29645025/dietary-fish-oil-ameliorates-adipose-tissue-dysfunction-in-insulin-resistant-rats-fed-a-sucrose-rich-diet-improving-oxidative-stress-peroxisome-proliferator-activated-receptor-%C3%AE-and-uncoupling-protein-2
#17
Dante Selenscig, María Del Rosario Ferreira, Adriana Chicco, Yolanda B Lombardo
This work aims to assess the possible beneficial effects of dietary fish oil (FO) on the pre-existing adipose tissue dysfunction through the improvement or reversion of the mechanisms underlying oxidative stress and pro-inflammatory cytokines in dyslipemic insulin-resistant rats. Wistar rats were fed a sucrose rich diet (SRD) for 6 months. After that half of the animals continued with the SRD until month 8 while in the other half corn oil was replaced by FO for 2 months (SRD + FO). A reference group consumed a control diet all the time...
April 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29629027/ethanol-extract-of-allium-fistulosum-inhibits-development-of-non-alcoholic-fatty-liver-disease
#18
Jin-Taek Hwang, Eun Ju Shin, Min-Yu Chung, Jae Ho Park, Sangwon Chung, Hyo-Kyoung Choi
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural product for application in the development of a treatment for NAFLD. MATERIALS/METHODS: The preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29626513/effects-of-exercise-training-on-adipose-tissue-apelin-expression-in-streptozotocin-nicotinamide-induced-diabetic-rats
#19
Fahimeh Kazemi, Saleh Zahediasl
Apelin is an adipocyte-derived peptide that plays an important role in regulation of energy homoeostasis and decrease of insulin resistance. We investigated the effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats. In this experimental study, 38 male Wistar rats were assigned to 4 groups: sedentary diabetic, trained diabetic, sedentary non-diabetic and trained non-diabetic. Type 2 diabetes mellitus (T2DM) was induced by intraperitoneal injection of streptozotocin and nicotinamide in adult rats...
April 4, 2018: Gene
https://www.readbyqxmd.com/read/29623204/cerebral-venous-thrombosis-revealing-beh%C3%A3-et-s-disease-in-a-moroccan-patient-a-case-report-and-literature-review
#20
Evelien Krumb, Chantal Lefebvre, André Peeters, Cédric Hermans
Behçet's disease is an inflammatory disease, the origin of which still remains unclear, and it has multiple manifestations , one of them being thrombosis. In this report, we describe the case of a 24-year-old Moroccan patient who presented with headache persisting for more than 2 weeks, which was found to be caused by cerebral venous sinus thrombosis. His medical history of recurrent oral and genital ulcerations, epididymitis and one episode of pericarditis led to the diagnosis of Behçet's disease. We could observe an almost complete relief of symptoms with colchicine therapy, and anticoagulation with warfarin was started for secondary prevention of thrombosis...
2018: SAGE Open Medical Case Reports
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