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https://www.readbyqxmd.com/read/29447836/sensory-denervation-of-inguinal-white-fat-modifies-sympathetic-outflow-to-white-and-brown-fat-in-siberian-hamsters
#1
REVIEW
Ngoc Ly T Nguyen, Bingzhong Xue, Timothy J Bartness
White adipose tissue (WAT) and brown adipose tissue (BAT) have sympathetic nervous system (SNS) and sensory innervations. Previous studies from our laboratory revealed central neuroanatomical evidence of WAT sensory and BAT SNS crosstalk with double labeling of inguinal WAT (IWAT) sensory and interscapular BAT (IBAT) SNS neurons. We previously demonstrated that WAT lipolysis increases IBAT temperature, but this effect is absent when IWAT afferents are surgically denervated, which severs both sensory and SNS nerves...
February 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29434272/modified-inguinal-microscope-assisted-varicocelectomy-under-local-anesthesia-a-non-randomised-controlled-study-of-3565-cases
#2
Jin Wang, Qian Liu, Xun Wang, Rijian Guan, Sen Li, Youpeng Zhang, Yongbiao Cheng, Hanqing Zeng, Yong Tang, Zhaohui Zhu
Varicocele is a common abnormality, but the conventional microsurgical subinguinal varicocelectomy (CMSV) has some disadvantages. We invented Modified Inguinal Microscope-Assisted Varicocelectomy (MIMV) under local anesthesia. This study aims to evaluate MIMV by comparing it to CMSV in operating duration, time to return to normal activity, postoperative complications, achievement of natural pregnancy and improvement of semen quality for patients with infertility, pain score for those with scrotal pain, and so on...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29434073/placental-growth-factor-plgf-is-linked-to-inflammation-and-metabolic-disorders-in-mice-with-diet-induced-obesity
#3
Mincheol Kang, Jain Jeong, Jinhee Lee, Song Park, Yonghun Sung, Minjee Choi, Wookbong Kwon, Soyoung Jang, Kwang Shik Choi, Yeon Sik Choo, Duhak Yoon, Myoung Ok Kim, Zae Young Ryoo
Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a major role in angiogenesis and vasculogenesis. Previous study demonstrated that PlGF-overexpressing transgenic (Tg) mice had gestational loss. In addition, PlGF secretion was up-regulated in isolated T lymphocytes (T-cell) upon CD3/CD28 stimulation, suggesting that PlGF could be a regulator of T-cell differentiation and development. T-cells are well known to play a critical role in obesity-induced inflammation...
February 9, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29434054/influence-of-dutasteride-and-nifedipine-on-catsper-gene-expression-in-epididymis-of-mice
#4
Archana Srivastav, Bendangla Changkija, Kunal Sharan, Geet Kumar Nagar, Falgun Wanganuji Bansode
Calcium (Ca2+) signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca2 + through CatSper (sperm specific cation channel). The CatSper channel complex contains four pore forming α subunits (CatSper1-4 ) and five accessory subunits called β, δ, ε, γ and ζ . Genetic deletion of any of the four CatSper genes in mice results in loss of hyperactivated motility and male infertility...
February 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29433777/lipid-metabolism-potential-and-mechanism-of-cpe-iii-from-chickpea-cicer-arietinum-l
#5
Zhaohui Xue, Xiaonan Hou, Wancong Yu, Haichao Wen, Qian Zhang, Dan Li, Xiaohong Kou
The effects of CPe-III on hyperlipidemic mice were investigated, along with molecular docking and dynamics analyses between CPe-III and CETP. This study was conducted in order to explore the lipid metabolism potential and mechanism of CPe-III. CPe-III significantly (P<0.05) reduced serum total cholesterol, triglyceride and hepatic triglyceride levels and increased serum superoxide dismutase activity. CPe-III reversed liver changes induced by a high-fat diet and significantly (P<0.05) reduced kidney and epididymal fat indices...
February 2018: Food Research International
https://www.readbyqxmd.com/read/29432804/effects-of-long-term-nitrate-supplementation-on-carbohydrate-metabolism-lipid-profiles-oxidative-stress-and-inflammation-in-male-obese-type-2-diabetic-rats
#6
Sevda Gheibi, Sajad Jeddi, Mattias Carlström, Hanieh Gholami, Asghar Ghasemi
PURPOSE: Supplementation with inorganic nitrate to boost the nitrate-nitrite-nitric oxide (NO) pathway, may act as a potential therapeutic agent in diabetes. The aim of this study was to determine the effects of nitrate on carbohydrate metabolism, lipid profiles, oxidative stress, and inflammation in obese type 2 diabetic rats. METHODS: Male Wistar rats were divided into 4 groups: Control, control + nitrate, diabetes, and diabetes + nitrate. Diabetes was induced using a high-fat diet and low-dose of streptozotocin...
February 9, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29430687/the-protective-effect-of-melatonin-on-sperm-quality-in-rat-after-radioiodine-treatment
#7
C Cebi Sen, N Yumusak, H I Atilgan, M Sadic, G Koca, M Korkmaz
This study was designed to investigate the potential radioprotective impact of melatonin on the testicular tissue and sperm quality in rat given radioactive iodine (RAI) therapy. Thirty-six male Wistar albino rats were randomly divided into three groups as untreated control (Group 1); oral radioiodine group (RAI, 111 MBq, administrated rats); and RAI+melatonin group (oral radioiodine and intraperitoneal 12 mg/kg/day melatonin, starting 2 days before and continuing for 1 week after oral RAI administration)...
February 11, 2018: Andrologia
https://www.readbyqxmd.com/read/29421645/feeding-of-tobacco-blend-or-nicotine-induced-weight-loss-associated-with-decreased-adipocyte-size-and-increased-physical-activity-in-male-mice
#8
Mingxia Liu, Chia-Chi Chuang Key, Allison Weckerle, Elena Boudyguina, Janet K Sawyer, Abraham K Gebre, Wayne Spoo, Om Makwana, John S Parks
Although epidemiological data and results from rodent studies support an inverse relationship between nicotine consumption and body weight, the molecular mechanisms are poorly understood. CD-1 mice were fed a basal diet or a basal diet containing low or high dose smokeless tobacco blend or high dose nicotine tartrate for 14 weeks. High dose tobacco blend and nicotine tartrate diets vs. basal diet reduced mouse body weight (16.3% and 19.7%, respectively), epididymal (67.6% and 72.5%, respectively) and brown adipose weight (42% and 38%, respectively), epididymal adipocyte size (46...
February 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29421624/comprehensive-overview-of-murine-epididymal-mononuclear-phagocytes-and-lymphocytes-unexpected-populations-arise
#9
Allison Voisin, Marjorie Whitfield, Christelle Damon-Soubeyrand, Chantal Goubely, Joëlle Henry-Berger, Fabrice Saez, Ayhan Kocer, Joël R Drevet, Rachel Guiton
Despite increasing evidence that epididymal immune disorders can lead to infertility, the cells and mechanisms underlying epididymal immunity remain poorly understood. In this study, we propose a rather exhaustive overview of innate and adaptive immune cells present in the murine caput and cauda epididymis. Using flow cytometry and a wide set of markers, we screened the broadest panel of immune cells ever, in this organ. For the first time, we unequivocally quantified the innate populations of monocytes, macrophages, and dendritic cells subtypes...
January 31, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29419789/aged-oolong-tea-reduces-high-fat-diet-induced-fat-accumulation-and-dyslipidemia-by-regulating-the-ampk-acc-signaling-pathway
#10
Erdong Yuan, Xuefei Duan, Limin Xiang, Jiaoyan Ren, Xingfei Lai, Qiuhua Li, Lingli Sun, Shili Sun
While oolong tea (OT) has been shown to induce weight loss and reduce fat accumulation, the mechanisms remain poorly defined, especially for aged OT. In this study, five groups of mice (n = 9/group) were used including a normal diet with vehicle treatment, and a high-fat diet (HFD) with vehicle or the water extracts from aged OTs (EAOTs, three different storage years) by oral gavage at 1000 mg/kg·BW for 6 weeks. Body weight, fat accumulation, and serum biochemical parameters were used to evaluate obesity. The morphology of hepatocytes and adipocytes was analyzed by being stained with hematoxylin and eosin...
February 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29415221/binder-of-sperm-proteins-1-and-5-have-contrasting-effects-on-the-capacitation-of-ram-spermatozoa
#11
Taylor Pini, Simon P de Graaf, Xavier Druart, Guillaume Tsikis, Valerie Labas, Ana Paula Teixeira-Gomes, Barend M Gadella, Tamara Leahy
Binder of Sperm Proteins (BSPs) are the most abundant seminal plasma protein family in the ram and bull. They have been extensively studied in the bull but less is known about their function in ovine seminal plasma and current knowledge suggests BSPs may have different effects in these two species. In the bull they facilitate capacitation and destabilize the sperm membrane during in vitro handling, whereas in the ram, they appear to stabilize the sperm membrane and prevent cryopreservation induced capacitation-like changes...
February 5, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29414316/ppar%C3%AE-agonist-rosiglitazone-switches-fuel-preference-to-lipids-in-promoting-thermogenesis-under-cold-exposure-in-c57bl-6-mice
#12
Rong Gao, Wei Chen, Huang Yan, Xinni Xie, Dongqi Liu, Chenxi Wu, Zhaohui Zhu, Haijing Li, Fangting Dong, Lili Wang
Brown and beige adipose tissues play key roles in adaptive thermogenesis, which is essential for homoiotherms to maintain core temperature under cold exposure. PPARγ is a transcriptional regulator critical for brown adipose tissue (BAT) recruitment and white adipose tissue (WAT) browning. Here we evaluated the impact of PPARγ activation on thermogenic activity in C57BL/6 mice under thermo-neutral and 4 °C cold environment, and revealed the regulating mechanism and metabolic basis. Rosiglitazone slowed body temperature loss in cold environment in C57BL/6 mice, suppressed cold-induced decreases in blood glucose, reversed cold-promoted 18F-FDG uptake, and increased lipid consumption in BAT...
January 27, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29411910/paratesticular-seminoma-echographic-features-and-histological-diagnosis-with-review-of-the-literature
#13
Andrea Palicelli, Pierluigi Neri, Giansilvio Marchioro, Paolo De Angelis, Gianmarco Bondonno, Antonio Ramponi
Primary extratesticular seminomas exceptionally occur in the epididymis or in the paratesticular region/spermatic cord. Some old papers included poor histological description or insufficient photographic documentation, reducing the number of faithful cases: an up-to-date systematic review is lacking. We report the 4th primary seminoma of the paratesticular region/spermatic cord in a 35-year-old man, including the first echographic description. We provide review of the literature and etiopathogenetic discussion...
February 7, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29411891/effect-of-gestational-diabetes-mellitus-on-testis-and-pancreatic-tissues-of-male-offspring
#14
G Türk, A Rişvanlı, A O Çeribaşı, M Sönmez, A Yüce, M Güvenç, H Arslan Özkan, N Canlı, M Yaman
The purpose of this study was to determine the effect of gestational diabetes mellitus (GDM) on some reproductive characteristics, testicular and pancreatic oxidative status and pancreatic endocrine receptor densities of male offspring at post-pubertal stage. A total of 36 1-day-old Wistar Albino male offspring including 12 pups of nontreated mothers (control group), 14 pups of 40 mg/kg STZ-injected mothers (STZ-40 group) and 10 pups of 60 mg/kg STZ-injected mothers (STZ-60 group) were used. The offspring were euthanised on post-natal day 60, their blood, reproductive organs and pancreatic tissues were obtained and examined...
February 7, 2018: Andrologia
https://www.readbyqxmd.com/read/29411409/the-impact-of-electric-fields-on-testis-physiopathology-sperm-parameters-and-dna-integrity-the-role-of-resveratrol
#15
R Aslankoc, N Gumral, M Saygin, N Senol, H Asci, F N Cankara, S Comlekci
This study investigated the long-term effects of electric fields (EF) which might cause physiopathological or morphological changes in the testis tissues of rats. We assumed that using resveratrol (RES) might reduce harmful effects of the EF. Thirty-two male Wistar Albino rats were randomly divided into four groups with eight animals in each; control, EF, EF + RES and RES. Malondialdehyde (MDA), superoxide dismutase, catalase, glutathione peroxidase and histopathological parameters were evaluated in testis tissue...
February 6, 2018: Andrologia
https://www.readbyqxmd.com/read/29410697/metabolomics-insights-into-the-modulatory-effects-of-long-term-compound-polysaccharide-intake-in-high-fat-diet-induced-obese-rats
#16
Mingyi Chen, Biyu Lu, Yuan Li, Yuanyuan Wang, Haihui Zheng, Danmin Zhong, Ziqiong Liao, Mengxia Wang, Fangli Ma, Qiongfeng Liao, Zhiyong Xie
Background: Polysaccharides can alleviate obesity in mammals; however, studies on mechanism of this alleviation are limited. A few studies have indicated that polysaccharides improve obesity by regulating the metabolism of the body. Therefore, a metabolomics approach, consisting of high resolution nuclear magnetic resonance (NMR) spectroscopy and a multivariate statistical technique, was applied to explore the mechanism of the protective effects of lentinan and Flos Lonicera polysaccharides (LF) on high-fat diet (HFD) induced obesity...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29410017/differential-response-to-caloric-restriction-of-retroperitoneal-epididymal-and-subcutaneous-adipose-tissue-depots-in-rats
#17
Takumi Narita, Masaki Kobayashi, Kaho Itakura, Rei Itagawa, Riho Kabaya, Yuka Sudo, Naoyuki Okita, Yoshikazu Higami
The beneficial actions of caloric restriction (CR) are partially mediated by metabolic remodeling of white adipose tissue (WAT). Recently, we showed that CR enhances de novo fatty acid (FA) biosynthesis and mitochondrial biogenesis, particularly in WAT. Here, to better understand the response of WAT to CR, we compare the effects of CR on three WAT depots in rats: retroperitoneal (rWAT), epididymal (eWAT) and subcutaneous (sWAT). Computed tomography and histological analysis showed that CR reduced the volume and average size of rWAT adipocytes...
February 1, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29409758/postprandial-regulation-of-natriuretic-peptides-in-vivo-and-of-their-receptors-by-fatty-acids-in-adipocytes-in-vitro
#18
Andreas Schmid, Jens Albrecht, Judith Brock, Maria Koukou, Efthymia Arapogianni, Andreas Schäffler, Thomas Karrasch
BACKGROUND AND AIM: Natriuretic peptides (NPs) and their receptors gain attention regarding adipocyte function. It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B, NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots (AT) of patients undergoing bariatric surgery (n = 44). PATIENTS, MATERIAL AND METHODS: The postprandial regulation of NT-proANP and NT-proBNP levels was measured by ELISA and was studied in two cohorts of healthy individuals undergoing an oral glucose tolerance test (OGTT) (n = 100) and an oral lipid tolerance test (OLTT) (n = 100)...
January 30, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29405165/the-expression-of-the-new-epididymal-luminal-protein-of-pdz-domain-containing-1-is-decreased-in-asthenozoospermia
#19
A-Juan Liang, Gui-Shuan Wang, Ping Ping, Shuang-Gang Hu, Yu Lin, Yi Ma, Zheng-Zheng Duan, Han-Shu Wang, Fei Sun
Spermatozoa are not mature until they transit the epididymis where they acquire motility and the ability to fertilize an egg through sequential modifications. The epididymis has three functional regions, caput, corpus, and cauda, and the luminal proteins of the epididymis play important roles in the above modifications. However, the proteins with differential enrichment between the caput and cauda are still largely unknown. To reveal the functions of the caput and cauda during sperm maturation, luminal proteins from caput and cauda of mice were analyzed by isobaric tag for relative and absolute quantitation (iTRAQ)...
January 19, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29402900/canagliflozin-an-sglt2-inhibitor-attenuates-the-development-of-hepatocellular-carcinoma-in-a-mouse-model-of-human-nash
#20
Kumiko Shiba, Kyoichiro Tsuchiya, Chikara Komiya, Yasutaka Miyachi, Kentaro Mori, Noriko Shimazu, Shinobu Yamaguchi, Naomi Ogasawara, Makoto Katoh, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa
Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined the preventive effects of an SGLT2 inhibitor canagliflozin (CANA) in Western diet (WD)-fed melanocortin 4 receptor-deficient (MC4R-KO) mice, a mouse model of human NASH. An eight-week CANA treatment attenuated hepatic steatosis in WD-fed MC4R-KO mice, with increased epididymal fat mass without inflammatory changes...
February 5, 2018: Scientific Reports
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