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https://www.readbyqxmd.com/read/28429532/neu1-sialidase-interacts-with-perilipin-1-on-lipid-droplets-and-inhibits-lipolysis-in-3t3-l1-adipocytes
#1
Yujin Natori, Miwako Nasui, Fumiko Kihara-Negishi
Fatty acids are stored within adipocytes in lipid droplets (LDs) as triacylglycerol (TG), which is converted to free fatty acid (FFA) and glycerol via lipolysis. Increased plasma FFA levels in obesity are associated with several clinical conditions. We previously found that Neu1 activity is aberrant in the epididymal fat and liver of obese and diabetic mice. Here, we examined involvement of Neu1 in lipolysis in 3T3-L1 adipocytes. Small interfering RNA against Neu1 was introduced into adipocytes, and glycerol concentrations were measured in the culture medium...
April 21, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28429094/prospective-evaluation-of-scrotal-ultrasound-and-intratesticular-perfusion-by-color-coded-duplex-sonography-ccds-in-tese-patients-with-azoospermia
#2
Bora Altinkilic, Adrian Pilatz, Thorsten Diemer, Julia Wolf, Martin Bergmann, Sarah Schönbrunn, Uwe Ligges, Hans-Christian Schuppe, Wolfgang Weidner
PURPOSE: The objective of this study was to assess whether CCDS might improve the outcome of testicular sperm retrieval in patients with azoospermia. Furthermore, we evaluated potential sonographic alterations of the testis before and after trifocal and Micro-TESE. METHODS: 78 patients were enrolled prospectively: 24 with obstructive azoospermia (OA) and 54 with non-obstructive azoospermia (NOA). 31 of 54 patients in the NOA group had negative surgical sperm retrieval...
April 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28429080/effect-of-gpr84-deletion-on-obesity-and-diabetes-development-in-mice-fed-long-chain-or-medium-chain-fatty-acid-rich-diets
#3
Eugene Du Toit, Liam Browne, Helen Irving-Rodgers, Helen M Massa, Nicolette Fozzard, Michael P Jennings, Ian R Peak
PURPOSE: Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well characterised. We set out to determine whether GPR84 expression influences obesity and glucose intolerance susceptibility in MCFA and LCFA rich diet fed mice...
April 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28428684/innate-immunity-of-adipose-tissue-in-rodent-models-of-local-and-systemic-staphylococcus-aureus-infection
#4
Andreas Schmid, Thomas Karrasch, Miriam Thomalla, Jutta Schlegel, Bernd Salzberger, Andreas Schäffler, Frank Hanses
Background. The role of adipose tissue in systemic inflammation during bacterial infection is unclear. Effects of Staphylococcus aureus infection on adipocytes in rodent models of experimental endocarditis and peritonitis, the impact of S. aureus infection on gene expression in epididymal and subcutaneous adipose tissue, and effects of S. aureus infection on the toll-like receptor-2- (TLR2-) cathelicidin pathway in vivo and in vitro were investigated. Material and methods. The rat model of catheter-induced S...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28422289/dietary-tuna-dark-muscle-protein-attenuates-hepatic-steatosis-and-increases-serum-high-density-lipoprotein-cholesterol-in-obese-type-2-diabetic-obese-kk-a-y-mice
#5
Hayato Maeda, Ryota Hosomi, Mari Fukuda, Yuki Ikeda, Munehiro Yoshida, Kenji Fukunaga
Tuna muscle consists of light and dark muscle in approximately equal proportions. However, besides for the light muscle of tuna, cod, sardine, and salmon, few researches have assessed the health-promoting functions of fish protein. Therefore, we evaluated the mechanisms underlying the alteration of lipid storage and cholesterol metabolism following the intake of tuna dark muscle protein (TDMP) by obese type-2 diabetic/obese mice. Four-week-old male KK-A(y) mice were separated into 2 dietary groups, with one group receiving a casein-based diet and the other receiving a diet with the substitution of part of the protein (50%, w/w) by TDMP (TDMP diet) for 4 wk...
April 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28421619/molecular-detection-of-chlamydia-trachomatis-and-semen-quality-of-sexual-partners-of-infertile-women
#6
M López-Hurtado, M Velazco-Fernández, M J E Pedraza-Sánchez, V R Flores-Salazar, R Villagrana Zesati, F M Guerra-Infante
Chlamydia trachomatis is considered as the bacterium that is more sexually transmitted as cause of male urethritis, epididymitis, orchitis and infertility. A total of 116 semen samples of men whose couples are infertile women were analysed. The quality of the semen was measured by standard procedures recommended by WHO while C. trachomatis was detected by the PCR assay. Thirty-seven semen samples were positive for C. trachomatis (31.9%). Regarding semen analysis, no different values were observed between positive and negative samples to C...
April 19, 2017: Andrologia
https://www.readbyqxmd.com/read/28421491/chapter-7-human-epididymal-and-testicular-sperm-cryopreservation
#7
Pankaj Talwar, Sarabpreet Singh
Since the advent of intracytoplasmic sperm injection (ICSI) in the early 1990s, surgical techniques to recover samples from the epididymis and testis directly have been used to benefit patients suffering from obstructive and nonobstructive azoospermia. Various studies have demonstrated comparable fertilization, ongoing pregnancy, and implantation rates when fresh and frozen-thawed epididymal sperms were used for ICSI [1]. Injection of fresh and frozen testicular sperms into mature oocytes resulted in similar fertilization rates in cases of obstructive azoospermia...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28417005/reversibility-of-vasalgel%C3%A2-male-contraceptive-in-a-rabbit-model
#8
Donald Waller, David Bolick, Elaine Lissner, Christopher Premanandan, Gary Gamerman
BACKGROUND: Development of a non-hormonal long-acting reversible contraceptive for men could have a significant impact on reducing unintended pregnancies. Vasalgel™ is a high molecular weight polymer consisting of styrene-alt-maleic acid (SMA) dissolved in dimethyl sulfoxide being developed as a reversible male contraceptive device. It forms a hydrogel when implanted into the vasa deferentia, which prevents the passage of sperm. Previous studies in the rabbit have proven its efficacy, durability and rapid onset...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28413943/assessment-on-occurrences-of-depression-and-anxiety-and-associated-risk-factors-in-the-infertile-chinese-men
#9
Bin Yang, Jianchao Zhang, Yuxia Qi, Pu Wang, Ronghuan Jiang, Hongjun Li
The prevalence of depression and anxiety in the Chinese male population with infertility is still uncertain. The prevalence of depression, anxiety, and a combination of both psychological symptoms was 20.8%, 7.8%, and 15.4%, respectively in 771 infertile Chinese men in the current study by the Mental Health Inventory-5 and the State-Trait Anxiety Inventory-Short Form questionnaires. Differences in demographics (age, education, and income) had no noticeable impact on the development of psychological symptoms...
May 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28412994/effects-of-high-fat-diet-on-somatic-growth-metabolic-parameters-and-function-of-peritoneal-macrophages-of-young-rats-submitted-to-a-maternal-low-protein-diet
#10
Maria Cláudia Alheiros-Lira, Gabriela Carvalho Jurema-Santos, Helyson Tomaz da-Silva, Amanda Cabral da-Silva, Sueli Moreno Senna, Wylla Tatiana Ferreira E Silva, José Candido Ferraz, Carol Góis Leandro
This study evaluated the effects of a post-weaning high-fat (HF) diet on somatic growth, food consumption, metabolic parameters, phagocytic rate and nitric oxide (NO) production of peritoneal macrophages in young rats submitted to a maternal low-protein (LP) diet. Male Wistar rats (aged 60 d) were divided in two groups (n 22/each) according to their maternal diet during gestation and lactation: control (C, dams fed 17 % casein) and LP (dams fed 8 % casein). At weaning, half of the groups were fed HF diet and two more groups were formed (HF and low protein-high fat (LP-HF))...
April 17, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28411010/effects-of-vitamin-d-and-resveratrol-on-metabolic-associated-markers-in-liver-and-adipose-tissue-from-samp8-mice
#11
Yehua Rui, Jinbo Cheng, Liqiang Qin, Cheng Shan, Jie Chang, Guiping Wang, Zhongxiao Wan
SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES: We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combination of vitamin D (VD) with resveratrol (RSV) will affect aging associated metabolic impairment in liver and adipose tissue from SAMP8 mice. METHODS: SAMP8 mice and their control SAMR1 mice were divided into 5 groups, i...
April 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28407435/sl15-a-seminal-plasma-derived-lectin-from-the-sperm-of-llama-lama-glama
#12
Renato Zampini, Sabrina Sequeira, Martin Eduardo Argañaraz, Silvana Andrea Apichela
The oviductal sperm reservoir of South American camelids is formed when sperm bind to N-acetylgalactosamine (GalNAc) on the surface of oviductal epithelium. The aim of this study was to characterize the GalNAc-binding proteins on llama sperm, and to establish their origin. Sperm-adsorbed proteins were extracted with 0.5 M KCl in Hepes-balanced salts. Sperm-adsorbed and seminal plasma proteins were then subjected to ligand blotting for their GalNAc affinity, and the labeled bands were identified by mass spectrometry...
April 13, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28405942/first-successful-conception-induced-by-a-male-cystinosis-patient
#13
Koenraad R Veys, Kathleen W D'Hauwers, Angelique J C M van Dongen, Mirian C Janssen, Martine T P Besouw, Ellen Goossens, Lambert P van den Heuvel, Alex A M M Wetzels, Elena N Levtchenko
Cystinosis is a rare autosomal recessive lysosomal storage disease characterized by multi-organ cystine accumulation, leading to renal failure and extra-renal organ dysfunction. Azoospermia of unknown origin is the main cause of infertility in all male cystinosis patients. Although spermatogenesis has shown to be intact at the testicular level in some patients, no male cystinosis patient has been reported yet to have successfully induced conception.We present the first successful conception ever reported, induced by a 27-year-old male renal transplant infantile nephropathic cystinosis patient through percutaneous epididymal sperm aspiration (PESA) followed by intracytoplasmatic sperm injection (ICSI)...
April 13, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28404627/multiphasic-regulation-of-systemic-and-peripheral-organ-metabolic-responses-to-cardiac-hypertrophy
#14
Chong Wee Liew, Shanshan Xu, Xuerong Wang, Maximilian McCann, Hyerim Whang Kong, Andrew C Carley, Jingbo Pang, Giamila Fantuzzi, J Michael O'Donnell, E Douglas Lewandowski
BACKGROUND: Reduced fat oxidation in hypertrophied hearts coincides with a shift of carnitine palmitoyl transferase I from muscle to increased liver isoforms. Acutely increased carnitine palmitoyl transferase I in normal rodent hearts has been shown to recapitulate the reduced fat oxidation and elevated atrial natriuretic peptide message of cardiac hypertrophy. METHODS AND RESULTS: Because of the potential for reduced fat oxidation to affect cardiac atrial natriuretic peptide, and thus, induce adipose lipolysis, we studied peripheral and systemic metabolism in male C57BL/6 mice model of transverse aortic constriction in which left ventricular hypertrophy occurred by 2 weeks without functional decline until 16 weeks (ejection fraction, -45...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28403740/bisphenol-a-induces-oxidative-stress-in-bone-marrow-cells-lymphocytes-and-reproductive-organs-of-holtzman-rats
#15
Dinesh Tiwari, Geeta Vanage
Bisphenol A (BPA) is an estrogenic chemical used in the production of polycarbonate plastics and epoxy resins. Our earlier studies have demonstrated that BPA is a potent reproductive and genotoxic agent and affects the normal physiological functions. The objective of this study was to evaluate whether exposure to BPA induces oxidative stress. The male Holtzman rats were orally gavaged with BPA (0.01 mg and 5.0 mg/kg/bw) over the period of 6 days. Animals were euthanized by cervical dislocation at the end of the treatments; bone marrow cells and blood lymphocytes were aspirated; testis and epididymis were collected, immediately frozen in liquid nitrogen, and stored at -80°C...
March 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28403493/-acute-idiopathic-scrotal-oedema-differential-diagnosis-of-the-acute-scrotum
#16
Annette Schröder
Acute idiopathic scrotal edema (AISE) is regarded as a rare cause of scrotal pain, swelling and erythema. Testicular torsion, torsion of the appendage, epididymitis, hernia and hydrocele are the most common causes of acute scrotum. The clinical symptoms of AISE are usually mild and the characteristic Doppler sonography findings make it a valuable differential diagnosis, which can help to avoid unnecessary exploration.
February 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28396530/downregulation-of-plzf-gene-ameliorates-metabolic-and-cardiac-traits-in-the-spontaneously-hypertensive-rat
#17
František Liška, Vladimír Landa, Václav Zídek, Petr Mlejnek, Jan Šilhavý, Miroslava Šimáková, Hynek Strnad, Jaroslava Trnovská, Vojtěch Škop, Ludmila Kazdová, Colby G Starker, Daniel F Voytas, Zsuzsanna Izsvák, Massimiliano Mancini, Ondřej Šeda, Vladimír Křen, Michal Pravenec
The spontaneously hypertensive rat (SHR), one of the most widely used model of essential hypertension, is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, quantitative trait loci influencing blood pressure, left ventricular mass, and heart interstitial fibrosis were genetically isolated within a minimal congenic subline that contains only 7 genes, including mutant Plzf (promyelocytic leukemia zinc finger) candidate gene. To identify Plzf as a quantitative trait gene, we targeted Plzf in the SHR using the transcription activator-like effector nuclease technique and obtained SHR line harboring targeted Plzf gene with a premature stop codon...
April 10, 2017: Hypertension
https://www.readbyqxmd.com/read/28395327/developmental-expression-of-the-dynamin-family-of-mechanoenzymes-in-the-mouse-epididymis%C3%A2
#18
Wei Zhou, Geoffry N De Iuliis, Adrian P Turner, Andrew T Reid, Amanda L Anderson, Adam McCluskey, Eileen A McLaughlin, Brett Nixon
The mammalian epididymis is an exceptionally long ductal system tasked with the provision of one of the most complex intraluminal fluids found in any exocrine gland. This specialized milieu is continuously modified by the combined secretory and absorptive of the surrounding epithelium and thus finely tuned for its essential roles in promoting sperm maturation and storage. While considerable effort has been focused on defining the composition of the epididymal fluid, relatively less is known about the intracellular trafficking machinery that regulates this luminal environment...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28395326/signaling-mechanisms-in-mammalian-sperm-motility%C3%A2
#19
Maria João Freitas, Srinivasan Vijayaraghavan, Margarida Fardilha
The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. Motility is only achieved when the sperm presents a fully functional flagellum, is capable of producing energy to fuel the movement, and suffers epididymal maturation and capacitation. Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28394360/differential-sympathetic-outflow-to-adipose-depots-is-required-for-visceral-fat-loss-in-response-to-calorie-restriction
#20
L M Sipe, C Yang, J Ephrem, E Garren, J Hirsh, C D Deppmann
The sympathetic nervous system (SNS) regulates energy homeostasis in part by governing fatty acid liberation from adipose tissue. We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in timing, pattern of activation, and habituation with the most dramatic contrast between visceral and subcutaneous adipose depots. Sympathetic drive toward visceral epididymal adipose is more than doubled early in weight loss and then suppressed later in the diet when weight loss plateaued...
April 10, 2017: Nutrition & Diabetes
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