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Laurence Jesel, Charlotte Berthon, Nathan Messas, Han S Lim, Mélanie Girardey, Halim Marzak, Benjamin Marchandot, Annie Trinh, Patrick Ohlmann, Olivier Morel
Aims: Takotsubo cardiomyopathy (TTC) is a stress-related transient cardiomyopathy. It is unclear whether TTC is associated with poorer prognosis when atrial arrhythmia (AA), atrial fibrillation or flutter, occurs. The purpose of this study was to assess the incidence of AA in patients with TTC, predictive factors of AA, and its association with mortality. Methods and results: We studied 214 consecutive cases of TTC over 8 years. The study cohort was divided into two groups-those with newly diagnosed AA (AA-group) and those without (non-AA group)...
July 10, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Keven Ang, Wern Ee Tang, Chee Fang Sum, Subramaniam Tavintharan, Su Chi Lim
Background: The progression trajectory of renal filtration function has not been well characterized in patients with early-onset type 2 diabetes mellitus (T2DM) although albuminuria is often reported in this population. We aim to study the risk of progressive chronic kidney disease (CKD) in individuals with early-onset T2DM. Methods: In total, 1189 T2DM participants were followed for 3.9 (interquartile range 3.2-4.7) years. Progressive CKD was defined as estimated glomerular filtration rate (eGFR) decline of ≥5 mL/min/1...
July 10, 2018: Nephrology, Dialysis, Transplantation
Teresa M Seccia, Brasilina Caroccia, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Gian Paolo Rossi
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APA) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoantibodies activating the angiotensin II type 1 receptor, have rapidly advanced the understanding of the biology of primary aldosteronism (PA), in particular that of APA. Hence, the main purpose of this review is to discuss how discoveries of the last decade could impact on histopathology analysis and clinical practice...
July 10, 2018: Endocrine Reviews
Esther J van Zuuren, Zbys Fedorowicz, Ton Kuijpers, Hanno Pijl
Background: It remains uncertain which diet is best for people with type 2 diabetes (T2D). Objective: We compared the effects of dietary carbohydrate restriction with fat restriction on markers of metabolic syndrome and quality of life in people with T2D. Design: This systematic review of randomized controlled trials (RCTs) and controlled clinical trials (CCTs) compares the effects of a low-carbohydrate [≤40% of energy (%)] diet with those of a low-fat (≤30%) diet over a period of ≥4 wk in patients with T2D...
July 11, 2018: American Journal of Clinical Nutrition
Ivana Šagud, Debora Zanolla, Beatrice Perissutti, Nadia Passerini, Irena Škorić
Praziquantel (PZQ) is an inexpensive, low toxicity BCS II class anthelmintic drug used for the treatment of neglected tropical diseases. In earlier papers a mechanochemical activation has been used to induce physical transformations on the drug which would ameliorate its solubility and hence its bioavailability and a systematic study of the effects of varying temperature, frequency and time of milling on drug melting enthalpy and drug recovery was given. In this communication, the focus is on the degradation products that are formed during this mechanical treatment of Praziquantel...
July 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Shino Magaki, Zhaoyi Tang, Spencer Tung, Christopher K Williams, Darrick Lo, William H Yong, Negar Khanlou, Harry V Vinters
Cerebral amyloid angiopathy (CAA), in which amyloid accumulates predominantly in the walls of arterioles and capillaries, is seen in most patients with Alzheimer disease (AD) and may contribute to compromise of blood-brain barrier (BBB) function seen in AD. We investigated the effects of CAA on BBB integrity by examining the expression of the endothelial marker CD31, basement membrane protein collagen IV (COL4), tight junction protein claudin-5, and fibrinogen, a marker of BBB leakage, by immunohistochemistry in the occipital cortex of autopsy brains with AD and capillary CAA (CAA type 1; n = 8), AD with noncapillary CAA (CAA type 2; n = 10), and AD without CAA (n = 7) compared with elderly controls (n = 10)...
June 11, 2018: Neurobiology of Aging
Sabrina Elisa Oliveira, Pauliane Melo Costa, Sara Batista Nascimento, Whocely Victor Castro, Rosy Iara Maciel de Azambuja Ribeiro, Hélio Batista Santos, Ralph Gruppi Thomé
Atrazine is a herbicide that is banned in Europe but remains widely used on different types of crops in several countries in the American continent. Atrazine is known to be an endocrine disruptor and its effects on gonads have been extensively reported, but the toxic action on other organs is poorly documented. In this paper, we investigated the toxicity of atrazine on the gills and spleens of Nile tilapia (Oreochromis niloticus). The median lethal concentration (LC50 ), capable of killing one-half of the test animals was calculated, and sublethal concentrations of atrazine were used in a semistatic and subchronic assay...
July 2, 2018: Aquatic Toxicology
Aaron R Folsom, Pamela L Lutsey, Susan R Heckbert, Kripa Poudel, Saonli Basu, Ron C Hoogeveen, Mary Cushman, Christie M Ballantyne
BACKGROUND: We previously showed that participants in the population-based Atherosclerosis Risk in Communities (ARIC) cohort with elevated blood biomarkers of inflammation or cardiac disease were at increased risk of venous thromboembolism (VTE). OBJECTIVE: We hypothesized now that ARIC participants with larger 6-year increases in three biomarkers - C-reactive protein (CRP), N-terminal pro B-type natriuretic peptide (NT-proBNP), and troponin T - also would have increased subsequent risk of VTE...
July 14, 2018: Journal of Thrombosis and Haemostasis: JTH
Haoyi Jin, Peng Liu, Yunhao Wu, Xiangli Meng, Mengwei Wu, Jiahong Han, Xiaodong Tan
Pancreatic cancer is one of the deadliest cancers with rapid disease progression, requiring further elucidation of its underlying molecular mechanisms and novel biomarkers for early detection. Exosomes are small extracellular vesicles that are released by multiple cell types acting as message carriers during intercellular communication and are promising biomarker candidates. However, the role of pancreatic cancer cell-derived exosomes in cancer progression and the application of these vesicles as novel diagnostic biomarkers are still not fully studied...
July 14, 2018: Cancer Science
Konstantinos Kosmas, Georgia Mitropoulou, Ioannis Provatas, Marios Stamoulas, Anna Marouga
OBJECTIVE: The aims of this study were to determine the expression of PTEN in endometrial adenocarcinomas (as a potential prognostic indicator before treatment) in imprint smears and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. METHODS: One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Allison Louthan, Daniel Doak
Integral projection and matrix population models are commonly used in ecological and conservation studies to assess the health and extinction risk of populations. These models use one (or more) measurable state variable(s), such as size or age, to predict individual performance which, ideally, is the sole determinant of an individual's expected fate. However, even if ecologists successfully identify and measure the observable state variable(s) that best predicts individual fate, we are rarely if ever able to perfectly measure state for many species, especially those with size structure, where total plant biomass or starch stores, for example, may be the best predictors of fate...
July 14, 2018: Ecology
Rachel B Ger, Jinzhong Yang, Yao Ding, Megan C Jacobsen, Carlos E Cardenas, Clifton D Fuller, Rebecca M Howell, Heng Li, R Jason Stafford, Shouhao Zhou, Laurence E Court
PURPOSE: Magnetic resonance imaging (MRI) provides non-invasive evaluation of patient's anatomy without using ionizing radiation. Due to this and the high soft-tissue contrast, MRI use has increased and has potential for use in longitudinal studies where changes in patients' anatomy or tumors at different time points are compared. Deformable image registration can be useful for these studies. Here we describe two data sets that can be used to evaluate the registration accuracy of systems for MR images, as it cannot be assumed to be the same as that measured on CT images...
July 14, 2018: Medical Physics
Sada Nand Pandey, Naseer Iqbal, Prashant K Singh, Nilisha Rastogi, Punit Kaur, Sujata Sharma, Tej P Singh
Ribosome inactivating protein (RIP) catalyzes the cleavage of glycosidic bond formed between adenine and ribose sugar of ribosomal RNA to inactivate ribosomes. Previous structural studies have shown that RNA bases, adenine, guanine and cytosine tend to bind to RIP in the substrate binding site. However, the mode of binding of uracil with RIP was not yet known. Here, we report crystal structures of two complexes of type 1 RIP from Momordica balsamina (MbRIP1) with base, uracil and nucleoside, uridine. The binding studies of MbRIP1 with uracil and uridine as estimated using fluorescence spectroscopy showed that the equilibrium dissociation constants (KD ) were 1...
July 14, 2018: Proteins
S Ramachandran, R C Strange, A A Fryer, F Saad, G I Hackett
BACKGROUND: Serum sex hormone-binding globulin levels have been associated with mortality in adult men with type 2 diabetes (T2DM). OBJECTIVES: To confirm the association of serum sex hormone-binding globulin with mortality and then determine whether this association is mediated by age and total testosterone concentration. MATERIALS AND METHODS: We studied 364 men (median age: 66 years) with T2DM over a median follow-up of 4.3 years using the Cox regression to study associations between sex hormone-binding globulin, age, total testosterone, and mortality...
July 13, 2018: Andrology
Lauren B Beach, Blair Turner, Dylan Felt, Rachel Marro, Gregory L Phillips
Low physical activity (PA), high sedentary behavior (SB), and overweight and obesity have been shown to associate with increased Type 2 diabetes risk among adolescents. We investigated PA, SB, and overweight and obesity among Youth Risk Behavior Survey (YRBS) respondents to determine if non-heterosexual youth may be at increased diabetes risk compared to heterosexual youth. Weighted city and state YRBS data were pooled across 44 jurisdictions biennially from 2009-2015, resulting in a sample size of 350,673 students...
July 13, 2018: Pediatric Diabetes
Xiaoyu Ren, Marcel Wesolek, Pierre Braunstein
Tritopic NCNHCN' ligands containing a central N-heterocyclic carbene (NHC) donor flanked by two chemically-different nitrogen donors (Nimine and Namine) are evaluated as potential tridentate pincer-type ligands in NiII complexes. The imidazolium chloride [(ImH){C(Me)=NDipp}(C2NMe2)]Cl (1) and the ammonium-imidazolium dichlorides [(ImH){C(Me)=NDipp}(C2NHMe2)]Cl2 (4) and [(ImH){C(Me)=NDipp}(C3NHMe2)]Cl2 (5), differing by the length (C2 or C3) of the alkyl spacer were used as precursors. Oxidative-addition of 1 to [Ni(cod)2] afforded the dinuclear bis-NHC NiII complex [Ni2Cl2{µ-C(Me)=NDipp-κ2Nimine,C}{μ-Im(C2NMe2)-κ3Namine,CNHC,Nimid}{Im[C(Me)=NDipp](C2NMe2)-κ1CNHC}] (2) resulting from partial ligand rearrangement...
July 14, 2018: Chemistry: a European Journal
C Wallis, K V Patel, M Marshall, R Staunton, L Milella, S Harris, L J Holcombe
OBJECTIVES: To determine the incidence and rates of progression of gingivitis and periodontitis in Labrador retrievers. MATERIALS AND METHODS: Fifty-three dogs, aged 1·1 to 5·9 years, had their periodontal health assessed every 6 months for up to 2 years. The extent of gingivitis and periodontitis was measured around the whole gingival margin of every tooth under general anaesthesia. RESULTS: All dogs had gingivitis at the initial assessment...
July 13, 2018: Journal of Small Animal Practice
Beatriz T Costa-Carvalho, Kathleen E Sullivan, Patrícia M Fontes, Fernanda Aimé-Nobre, Isabela G S Gonzales, Elaine S Lima, Celso Granato, Maria Isabel de Moraes-Pinto
PURPOSE: Poliovirus has been nearly eliminated as part of a world-wide effort to immunize and contain circulating wild-type polio. Nevertheless, poliovirus has been detected in water supplies and represents a threat to patients with humoral immunodeficiencies where infection can be fatal. To define the risk, we analyzed antibodies to poliovirus 1, 2, and 3 in serum samples collected over a year from patients with primary immunodeficiency diseases (PID) on regular intravenous immunoglobulin (IVIG) replacement...
July 14, 2018: Journal of Clinical Immunology
Teiko Sakurai, Hidenori Kusumoto, Tomoko Wakasa, Yoshio Ohta, Eiichi Konishi, Hiroyuki Shiono
BACKGROUND: Epithelioid sarcoma (ES) is a rare variant of soft tissue sarcoma. The proximal type of ES occurs in various locations. We present a resected case with proximal-type ES that occurred in the chest wall and discuss the relevant literature. CASE PRESENTATION: A 47-year-old woman was referred for a 6-month history of a right anterior chest mass with tenderness. Chest computed tomography showed an invasive chest wall mass with calcification surrounding the third rib...
July 13, 2018: Surgical Case Reports
Toshihide Shima, Hirofumi Uto, Kohjiro Ueki, Yutaka Kohgo, Kohichiroh Yasui, Naoto Nakamura, Tatsuaki Nakatou, Toshinari Takamura, Sumio Kawata, Kazuo Notsumata, Kyoko Sakai, Ryosuke Tateishi, Takeshi Okanoue
BACKGROUND: We reported a cross-sectional study on causes of liver injury in Japanese type 2 diabetes mellitus (T2D) patients (JG 2013). We assessed overall and cause-specific mortality risk during follow-up of patients enrolled in JG 2013. METHODS: This was a longitudinal, multicenter cohort study. Of the 5642 Japanese T2D patients who visited T2D clinics of nine hospitals in the original study, 3,999 patients were followed up for an average of 4.5 years. Expected deaths in T2D patients were estimated using age-specific mortality rates in the general population (GP) of Japan...
July 13, 2018: Journal of Gastroenterology
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