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Hepatocellular carcinoma surgery

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https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#1
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29445059/liver-cirrhosis-and-or-hepatocellular-carcinoma-occurring-late-after-the-fontan-procedure-a-nationwide-survey-in-japan
#2
Masanari Kuwabara, Koichiro Niwa, Tomohiko Toyoda, Takeaki Shirai, Shigeru Tateno, Hideo Ohuchi, Yasuhiko Tanaka, Fukiko Ichida, Tomoo Fujisawa, Teiji Akagi, Yoshiki Mori
BACKGROUND: Fontan-associated liver disease (FALD) is an important late complication involving liver dysfunction, such as liver cirrhosis (LC) and hepatocellular carcinoma (HCC), in patients undergoing the Fontan procedure. However, the prevalence, clinical manifestation, and methods of diagnosis of FALD are still not well established.Methods and Results:This study comprised 2 nationwide surveys in Japan. First, the prevalence of LC and/or HCC in patients undergoing the Fontan procedure was determined...
February 14, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29442216/psychiatric-comorbidities-among-patients-undergoing-liver-transplantation-in-south-korea-a-nationwide-population-based-study
#3
Jaesung Heo, O Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
OBJECTIVES: The aim of this study was to analyze the prevalence of mental disorders in patients undergoing liver transplantation (LT) based on claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea. METHODS: We confirmed mental disorders in a nationwide cohort of 3758 patients receiving LT between January 2010 and December 2014. We categorized the prevalence of mental disorders based on patient age at the time of LT. RESULTS: A total of 288 patients for LT were diagnosed with a mental disorder 1 year before their cancer diagnosis...
February 13, 2018: Hepatology International
https://www.readbyqxmd.com/read/29434976/prediction-of-long-term-survival-rates-in-patients-undergoing-curative-resection-for-solitary-hepatocellular-carcinoma
#4
Yi Cao, Zhelong Jiang, Shaohu Wang, Haoyang Zhang, Yi Jiang, Lizhi Lv
The present study developed a novel laboratory-based algorithm to predict long-term survival rates in patients undergoing curative resection for solitary hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The present study included 426 patients with solitary HBV-related HCC who underwent surgery for primary tumors at a single center between 2003 and 2012. Demographic characteristics, laboratory analysis, clinical pathology and immunohistochemistry of topoisomerase II-a and Ki67 were analyzed. A simple prognostic risk calculator was developed using regression coefficients from multivariate models...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434654/quasispecies-variant-of-pre-s-s-gene-in-hbv-related-hepatocellular-carcinoma-with-hbs-antigen-positive-and-occult-infection
#5
Yuri Hatazawa, Yoshihiko Yano, Rina Okada, Toshihito Tanahashi, Hiroki Hayashi, Hirotaka Hirano, Akihiro Minami, Yuki Kawano, Motofumi Tanaka, Takumi Fukumoto, Yoshiki Murakami, Masaru Yoshida, Yoshitake Hayashi
Background: Hepatocellular carcinoma (HCC) can develop in patients who are negative for the hepatitis B surface antigen (HBsAg) in serum but positive for hepatitis B virus (HBV) DNA in the liver, referred to as occult HBV infection (OBI). Previous reports showed that HBV variants in OBI-related HCC are different from those in HBsAg-positive HCC. In the present study, HBV quasispecies based on the pre-S/S gene in OBI-related HCC patients were examined by high throughput sequencing and compared with those in HBsAg-positive HCC...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29433942/fontan-associated-liver-disease
#6
Luis Téllez, Enrique Rodríguez de Santiago, Agustín Albillos
Fontan-associated liver disease refers to the disturbance in the liver secondary to hemodynamic changes and systemic venous congestion following Fontan surgery. Although the natural history of this disease has not yet been established, patients with more advanced liver injury develop the complications of portal hypertension, such as ascites, variceal haemorrhage, or encephalopathy. Moreover, patients with Fontan surgery may have an increased risk of hepatocellular carcinoma. Periodic liver monitoring is essential to prevent this disease and provide early treatment of liver complications...
February 9, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29426971/laparoscopic-versus-open-right-posterior-sectionectomy-for-hepatocellular-carcinoma-in-a-high-volume-center-a-propensity-score-matched-analysis
#7
Jinsoo Rhu, Sung Joo Kim, Gyu Seong Choi, Jong Man Kim, Jae-Won Joh, Choon Hyuck David Kwon
BACKGROUND: While minimal invasive surgery is becoming popular in liver resection, right posterior sectionectomy (RPS) is still considered as a difficult procedure. We summarize the clinical data and investigate the feasibility of laparoscopic right posterior sectionectomy (LRPS) in hepatocellular carcinoma (HCC) by comparing its outcomes with those of open right posterior sectionectomy (ORPS). METHODS: We retrospectively reviewed 191 patients who underwent RPS for HCC during January 2009 to August 2016 at Samsung Medical Center...
February 9, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29420370/hepatoblastoma-in-a-child-with-early-onset-cirrhosis
#8
Julie Bennett, Melanie Kirby-Allen, Vicky Ng, John S Waye, Catherine T Chung, Furqan Shaikh
Hepatoblastoma is the most common hepatic malignancy of childhood with known genetic predispositions and perinatal risk factors, with rare case reports occurring in the setting of cirrhosis. This case describes a young patient with cirrhosis attributed to early-onset hereditary hemochromatosis who was diagnosed with hepatoblastoma with uncommon histologic findings, evidence of chemotherapy resistance who ultimately succumbed to her disease. It is important to consider diagnoses beyond hepatocellular carcinoma in this scenario and consider early biopsy...
February 7, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29417360/42-573-cases-of-hepatectomy-in-china-a-multicenter-retrospective-investigation
#9
Binhao Zhang, Bixiang Zhang, Zhiwei Zhang, Zhiyong Huang, Yifa Chen, Minshan Chen, Ping Bie, Baogang Peng, Liqun Wu, Zhiming Wang, Bo Li, Jia Fan, Lunxiu Qin, Ping Chen, Jingfeng Liu, Zhe Tang, Jun Niu, Xinmin Yin, Deyu Li, Songqing He, Bin Jiang, Yilei Mao, Weiping Zhou, Xiaoping Chen
Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma (HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed...
February 2, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29405333/fluorescent-peptide-highlights-micronodules-in-murine-hepatocellular-carcinoma-models-and-human-in-vitro
#10
Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang, HaiFang Yin
Early detection and clear delineation of microscopic lesions during surgery are critical to the prognosis and survival of patients with hepatocellular carcinoma (HCC), a devastating malignancy without effective treatments except for resection. Tools to specifically identify and differentiate micronodules from normal tissue in HCC patients can have a positive impact on survival. Here, we discovered a peptide that preferentially binds to HCC cells through phage display. Significant accumulation of the fluorescence-labeled peptide in tumor from ectopic and orthotopic HCC mice was observed within 2 h of systemic injection...
February 5, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29402556/electrochemotherapy-as-treatment-option-for-hepatocellular-carcinoma-a-prospective-pilot-study
#11
Mihajlo Djokic, Maja Cemazar, Peter Popovic, Bor Kos, Rok Dezman, Masa Bosnjak, Martina Niksic Zakelj, Damijan Miklavcic, Stojan Potrc, Borut Stabuc, Ales Tomazic, Gregor Sersa, Blaz Trotovsek
BACKGROUND AND OBJECTIVES: Electrochemotherapy provides non-thermal ablation of cutaneous as well as deep seated tumors. Based on positive results of the treatment of colorectal liver metastases, we conducted a prospective pilot study on hepatocellular carcinomas with the aim of testing the feasibility, safety and effectiveness of electrochemotherapy. PATIENTS AND METHODS: Electrochemotherapy with bleomycin was performed on 17 hepatocellular carcinomas in 10 patients using a previously established protocol...
February 2, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29398041/the-effect-of-prior-upper-abdominal-surgery-on-outcomes-after-liver-transplantation-for-hepatocellular-carcinoma-an-analysis-of-the-database-of-the-organ-procurement-transplant-network
#12
Jack P Silva, Nicholas G Berger, Ziyan Yin, Ying Liu, Susan Tsai, Kathleen K Christians, Callisia N Clarke, Harveshp Mogal, T Clark Gamblin
OBJECTIVES: Orthotopic liver transplantation (OLT) is the preferred treatment for hepatocellular carcinoma (HCC) in select patients. Many patients listed for OLT have a history of prior upper abdominal surgery (UAS). Repeat abdominal surgery increases operative complexity and may cause a greater incidence of complication. This study sought to compare outcomes after liver transplantation for patients with and without prior UAS. METHODS: Adult HCC patients undergoing OLT were identified using the database from the Organ Procurement and Transplantation Network (1987-2015)...
February 2, 2018: Surgery
https://www.readbyqxmd.com/read/29397626/-the-study-of-nomogram-based-on-ishak-inflammation-score-for-recurrence-of-hepatocellular-carcinoma-after-curative-resection
#13
X Y Luo, C Y Du, X F Wei, N Jiang, M Li, R Liao
Objective: To investigate the correlation between Ishak inflammation score and the clinicopathological characteristics and recurrence of patients with hepatocellular carcinoma (HCC) after curative resection, and then set up a recurrence nomogram for HCC. Methods: A total of 326 patients with HCC after curative resection from January 2006 to December 2009 were studied retrospectively as training cohort and 110 HCC patients after surgery from January 2010 to December 2012 were used as validation cohort.Clinical follow-up data and peritumoral Ishak inflammation score in training cohort were used to set up a nomogram predicting recurrence of HCC, which was verified by validation cohort...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29394834/-splenic-artery-left-common-iliac-artery-bypass-for-hepatocellular-carcinoma-with-celiac-artery-compression-syndrome-a-case-report
#14
Yoshiaki Ohmura, Yutaka Takeda, Masao Yoshitatsu, Yoshiteru Katsura, Takuya Sakamoto, Hiroki Mizoguchi, Takashi Shirakawa, Junichi Inatome, Kohei Murakami, Atsushi Naito, Yoshinori Kagawa, Toru Masuzawa, Atsushi Takeno, Chiyomi Egawa, Kohei Murata
Celiac artery compression syndrome(CACS)is a rare disorder characterized by postprandial intestinal angina caused by insufficient blood supply to the gastrointestinal organs. In this syndrome, the root of the celiac artery is compressed and narrowed by the median arcuate ligament of the diaphragm during expiration, sometimes causing difficulties in trans-arterial intervention. We report here a case that trans-hepatic arterial intervention was able to performed by splenic bypass. A 74- year-old man with multiple hepatocellular carcinoma(HCC)was performed the angiography, and diagnosed as CACS due to celiac artery root obstruction...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394787/-a-successful-curative-resection-case-of-metastatic-hepatocellular-carcinoma-to-the-kidney-which-extended-into-the-renal-vein
#15
Hiroyuki Inoue, Toshiya Ochiai, Hiroki Nakatsuji, Nobuyuki Watanabe, Hiroshi Ito, Atsushi Yoshiyama, Atsushi Toma, Kenji Nakamura, Eigo Otsuji
A 78-year-old woman underwent partial hepatectomy for the treatment of hepatocellular carcinoma(HCC).After surgery, she was further treated with radiofrequency ablation(RFA)and transcatheter arterial embolization(TAE)for the intrahepatic reccurence of HCC.Thirty months after surgery, her tumor marker levels increased and computed tomography (CT)revealed an intrahepatic mass and right renal tumor which extended into the renal vein.We therefore suspected a reccurence of HCC and right renal cell carcinoma which extended into the renal vein, and thus performed right nephrectomy before again performing TAE to treat the reccurence of HCC...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394736/-surgical-resection-of-peritoneal-recurrence-of-hepatocellular-carcinoma-with-endoscopic-fluorescence-imaging-system
#16
Sadaaki Nishimura, Akira Tomokuni, Shogo Kobayashi, Kei Asukai, Hirofumi Akita, Hidenori Takahashi, Yoshitomo Yanagimoto, Yusuke Takahashi, Norikatsu Miyoshi, Keijiro Sugimura, Kazuyoshi Yamamoto, Takeshi Ohmori, Masayuki Ohue, Masahiko Yano, Masato Sakon
A 66-year-old man presented with recurrences in the peritoneum 3 years after heavy particle beam therapy with hepatocellular carcinoma(HCC)and underwent laparoscopic surgery.Five months after surgery, a new peritoneal dissemination found in the vicinity of the colon hepatic flexure area by CT examination, and laparoscopic resection was planned again.Indocyanine green(ICG)0.5 mg/kg was administered on the day before surgery.ICG imaging by the PINPOINT®system revealed 2 small ICG accumulation sites in the diaphragm, as well as the main lesion, and each lesion was excised laparoscopically...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394727/-a-case-report-of-inguinal-malignant-lymphoma-after-surgery-for-hepatocellular-carcinoma
#17
Yuki Ohzato, Masahiro Murakami, Junzo Shimizu, Chikato Koga, Daiki Marukawa, Yuta Yoshida, Akinobu Yasuyama, Tae Matsumura, Akihiro Takada, Chizu Kameda, Ryohei Kawabata, Masaki Hirota, Shingo Noura, Hideaki Miwa, Junichi Hasegawa
An 81-year-old woman was followed up for hepatitis C from 1994. Sheh ad a previous history of hypertension and appendicitis. In October 2014, the patient underwent subsegmentectomy(S8)and cholecystectomy for hepatocellular carcinoma (HCC)(T2N0M0, Stage II ). From December 2015, the patient had taken ledipasvir-sofosbuvir orally for hepatitis C virus (HCV). In January 2016, we confirmed HCV-RNA shade transformation. In September 2016, enhanced CT showed a mass in theright lower quadrant of her abdomen. Shehad a hard 3 cm mass in thesameplaceon physical exam...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390573/totally-laparoscopic-radiofrequency-assisted-liver-partition-with-portal-vein-ligation-for-hepatocellular-carcinoma-in-cirrhotic-liver
#18
Zhixia Rong, Qian Lu, Jun Yan
RATIONALE: Adequate future liver remnant (FLR) volume is often a concern for patients with hepatocellular carcinoma (HCC). Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure can rapidly lead to impressive growth of FLR. We describe the technique of an entirely laparoscopic radiofrequency-assisted liver partition with portal vein ligation for staged hepatectomy (RALPP) in a cirrhotic patient with HCC. PATIENT CONCERNS: A 33 year-old female cirrhotic patient with HCC in the right liver was indicated for RALPP as the predicted future liver remnant (FLR) was 21%...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390333/atypical-hemangioma-mimicking-mixed-hepatocellular-cholangiocarcinoma-case-report
#19
Shengzhang Lin, Lele Zhang, Mengxia Li, Qiyang Cheng, Liang Zhang, Shusen Zheng
RATIONALE: Hemangioma of the liver is a benign hepatic tumor, more common in women than in men, which is typically asymptomatic, solitary, and incidentally discovered. Atypical hemangioma is a variant of hepatic hemangioma with atypical imaging finding features on CT and MRI that can be confused with hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and mixed hepatocellular cholangiocarcinoma (HCC-CC). PATIENT CONCERNS: We report a case of atypical hepatic hemangioma mimicking HCC-CC: A 59-year-old man was referred to our hospital for a hepatic lesion that was 4...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390320/local-resection-of-rectal-neuroendocrine-tumor-with-first-clinical-manifestation-of-giant-liver-metastasis-by-transanal-endoscopic-microsurgery-a-case-report
#20
Gang Xu, Peipei Wang, Yao Xiao, Xin Wu, Guole Lin
RATIONALE: Rectal neuroendocrine tumor (NET) is a relatively rare tumor. Well-differentiated NETs (G1 and G2) rarely display distant metastasis at initial diagnosis. Currently, treatment for the primary lesions of rectal NETs with liver metastasis remains controversial. The liver metastasis was resected in local hospital. Transanal endoscopic microsurgery (TEM) has emerged as an effective minimally invasive surgery for local resection of lower rectal lesions. Herein, we reported the initial application of TEM to remove the rectal primary lesion in patients with low rectal NETs (G2) with giant liver metastases...
December 2017: Medicine (Baltimore)
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