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Hepatocellular carcinoma surgery

Giovanni Battista Levi Sandri, Gabriele Spoletini, Giovanni Vennarecci, Elisa Francone, Mohammed Abu Hilal, Giuseppe Maria Ettorre
OBJECTIVE: In this study, we aim to assess the impact of tumor size on clinical and oncological outcomes in patients undergoing laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC). BACKGROUND: LLR has been shown to be feasible, safe, and oncologically efficient. However, it has been slow to develop in patients with HCC who often suffer from chronic liver disease which represents an additional challenge for the surgeon. The experience with large HCCs is even more limited...
May 16, 2018: Surgical Endoscopy
Koki Maeda, Goro Honda, Masanao Kurata, Yuki Homma, Manami Doi, Jun Yamamoto, Yusuke Ome
BACKGROUND: In our process of standardizing laparoscopic right hemihepatectomy (Lap-RH), we found several advantages of the laparoscopic caudate lobe first approach by utilizing a unique laparoscopic caudodorsal view. METHODS: Between April 2012 and October 2017, 21 patients underwent pure Lap-RH at our hospital. The mean patient age was 62 years (range, 36-75 years), and there were more male than female patients (66.7%). Of 21 patients, 11 had hepatocellular carcinoma, 8 had metastatic tumor, and the other 2 had focal nodular hyperplasia and refractory liver abscess...
May 17, 2018: Journal of Hepato-biliary-pancreatic Sciences
Danijel Galun, Aleksandar Bogdanovic, Jelena Djokic Kovac, Predrag Bulajic, Zlatibor Loncar, Marinko Zuvela
Purpose: The aim of the study was to evaluate a prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on long-term survival of cirrhotic and noncirrhotic hepatocellular cancer (HCC) patients managed by a curative-intent liver surgery in a developing country. Patients and methods: During the study period between November 1, 2001, and December 31, 2012, 109 patients underwent potentially curative hepatectomy for HCC. Data were retrospectively reviewed from the prospectively collected database...
2018: Cancer Management and Research
Yoshihiro Inoue, Ryo Tanaka, Kensuke Fujii, Nao Kawaguchi, Masatsugu Ishii, Shinsuke Masubuchi, Masashi Yamamoto, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
INTRODUCTION: The rising proportion of elderly patients (aged 80 yearsor above) in our population means that more elderly patients are undergoing hepatectomy. METHODS: Five-hundred and thirty patients who underwent hepatectomy for hepatocellular carcinoma (HCC) were retrospectively analyzed with respect to their preoperative status and perioperative results, including remnant liver regeneration. The remnant liver volume was postoperatively measured with multidetector CT on postoperative day 7 and 1, 2, 5, and 12 months after surgery...
May 14, 2018: Digestive Surgery
Emmanuel Gabriel, Jin Kim, Katherine T Ostapoff, Kristopher Attwood, Sergei Kurenov, Boris Kuvshinoff, Steven N Hochwald, Steven J Nurkin
Background: Estimation of preoperative overall survival (OS) of hepatocellular carcinoma (HCC) may guide surgical decision-making. Methods: OS was analyzed using the National Cancer Data Base from 1998-2012. Patients with HCC who underwent wedge resection, lobectomy or extended lobectomy were selected. Patients who had metastatic disease or previous treatment prior to surgery were excluded. Data was randomly allocated to model building (nb =4,364) and validation cohorts (nv =1,091)...
April 2018: Journal of Gastrointestinal Oncology
Tan To Cheung, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Simon Hing Yin Tsang, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Chung Mau Lo
INTRODUCTION: Laparoscopic hepatectomy is considered an acceptable treatment of choice in selected patients with primary hepatocellular carcinoma (HCC). Whether indocyanine green (ICG) immunofluorescence, a new technology, may improve surgery outcomes has yet to be tested. The aim of the present study was to investigate and compare the effect of ICG fluorescence imaging on the outcomes of pure laparoscopic hepatectomy and open hepatectomy for primary HCC with background cirrhosis. METHODS: From January 2015 to June 2016, 20 patients with HCC and liver cirrhosis underwent laparoscopic hepatectomy with ICG immunofluorescence...
May 10, 2018: Asian Journal of Endoscopic Surgery
Zhishi Yang, Wenhao Qin, Yao Chen, Bo Yuan, Xiaoling Song, Bibo Wang, Feng Shen, Jing Fu, Hongyang Wang
Cholesterol plays a vital role in modulating the action of membrane proteins critical to cellular function. The effect of serum cholesterol on the prognosis of hepatocellular carcinoma (HCC) patients remains uncertain. Here, we report that high levels of cholesterol predict good survival and low disease recurrence after surgery. Cholesterol could significantly suppress migration and invasion of HCC cells and restrain metastasis of HCC in mice. High levels of cholesterol promoted CD44 translocation into lipid rafts and attenuated CD44-Ezrin binding, which are crucial for cell migration and cancer metastasis...
May 7, 2018: Cancer Letters
Niki Christou, Nabil Dib, Etienne Chuffart, Abdelkader Taibi, Sylvaine Durand-Fontanier, Denis Valleix, Muriel Mathonnet
Patients with congenital agenesis of the portal vein may develop hepatocellular tumors due to enhanced arterial blood flow. These tumors may be benign (FNH, adenomas) or malignant (hepatoblastoma, HCC). Liver resection can be proposed, and preoperative arterial embolization may decrease blood loss during surgery. Liver transplantation with PV reconstruction is also an option.
May 2018: Clinical Case Reports
Qingjie Song, Xi Chen, Weidong Hu, Guanglin Mei, Xiaobing Yang, Han Wu
Epstein-Barr virus-induced gene 3 (EBI3) encodes a secretory glycoprotein, and has previously been identified as upregulated in various types of tumors. The presnet study examined the clinical significance of EBI3 expression for predicting tumor recurrence and survival after resection in hepatocellular carcinoma (HCC). EBI3 expression in various HCC cell lines and in 20 pairs of tumor and peritumor tissue samples were detected using western blot analysis. Immunohistochemical staining using tissue microarray with 312 samples from randomly selected patients with HCC who underwent surgery...
May 2018: Oncology Letters
Mou Li, Xing-Ju Zheng, Zi-Xing Huang, Bin Song
OBJECTIVE: To predict histological grade of hepatocellular carcinoma (HCC) in Wistar rats using intravoxel incoherent motion imaging (IVIM) with magnetic resonance imaging (MRI). METHODS: Liver lesions of HCC rat models induced by oral diethylnitrosamine (DEN) were scanned by IVIM to obtain apparent diffusion coefficient (ADC) and IVIM parameters,including true diffusion coefficient (D),pseudodiffusion coefficient (D*) and perfusion fraction (f). These HCC lesions were confirmed by Hematoxylin-Eosin (HE) stain and pathologically graded into low (grade Ⅰ+Ⅱ) and high (grade Ⅲ+Ⅳ) using the Edmondson-Steiner method...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Josep Marti, Massimo Giacca, Kutaiba Alshebeeb, Sumeet Bahl, Charles Hua, Jeremy C Horn, Jad BouAyache, Rahul Patel, Marcelo Facciuto, Myron Schwartz, Sander Florman, Edward Kim, Ganesh Gunasekaran
PURPOSE: To analyze outcomes of patients with hepatocellular carcinoma (HCC) undergoing preoperative portal vein embolization (PVE). MATERIALS AND METHODS: A retrospective analysis of survival, recurrence, and complications was performed in 82 patients with HCC undergoing preoperative PVE and surgical treatment with curative intention from June 2006 to December 2014. RESULTS: Rate of major adverse events after PVE was 11% with no mortality...
May 5, 2018: Journal of Vascular and Interventional Radiology: JVIR
Shuang Liu, Lei Guo, Hui Li, Bo Zhang, Jialei Sun, Chenghao Zhou, Jian Zhou, Jia Fan, Qinghai Ye
BACKGROUND: It remains uncertain whether patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) benefit from postoperative adjuvant trans-arterial chemoembolization (PA-TACE). METHODS: We retrospectively identified 540 patients to form the crude cohort and adopted propensity score matching analysis to assemble another cohort of 464 patients with similar baseline characteristics. Univariate and multivariate Cox analyses were performed in exploratory subgroups to identify the independent effect of PA-TACE on overall survival (OS)...
May 4, 2018: Annals of Surgical Oncology
Chee-Chien Yong, Ahmed M Elsarawy, Shih-Ho Wang, Tsan-Shiun Lin, Chih-Chi Wang, Wei-Feng Li, Ting-Lung Lin, Fang-Ying Kuo, Yu-Fan Cheng, Chao-Long Chen, Chih-Che Lin
BACKGROUND: Hepatocellular carcinoma (HCC) is increasingly managed by liver resection first then salvage liver transplantation in case of recurrence within accepted criteria. Many reports compared the safety of the salvage against the primary surgery in the setting of deceased donation but the difference in case of living donation is not sufficiently defined. Salvage living donor liver transplantation (SLDLT) is believed to be a more challenging surgery than primary living donor liver transplantation (PLDLT) due to operative field adhesions, in addition to the inherent difficulties particularly short vasculobiliary stumps...
April 30, 2018: International Journal of Surgery
Megumi Matsuo, Katsunori Furukawa, Hiroaki Shimizu, Hideyuki Yoshitomi, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Hiroyuki Nojima, Masayuki Ohsuka
BACKGROUND: Hepatocellular carcinoma (HCC) during pregnancy is rare, with a poor prognosis. Recently, however, increasing resection rates have improved survival rate. Currently, various surgeries are safely performed after the second trimester and termination of pregnancy is not always necessary. However, surgery is sometimes limited by gestational age or the patient's will. When patients with HCC refuse surgery during pregnancy, we face specific problems with respect to curability and fetal life...
May 2, 2018: Surgical Case Reports
Huihui Yan, Xihui Gao, Yunfei Zhang, Wenju Chang, Jianhui Li, Xinwei Li, Qin Du, Cong Li
Surgery is a mainstay for treating hepatocellular carcinoma (HCC). However, it is a great challenge for surgeons to identify HCC in its early developmental stage. The diagnostic sensitivity for tiny HCC with a diameter less than 1.0 cm is usually as low as 10-33% for computed tomography (CT) and 29-43% for magnetic resonance imaging (MRI). Although MRI is the preferred imaging modality for detecting HCC, with its unparalleled spatial resolution for soft tissue, the commercially available contrast agents, such as Gd3+ -DTPA, cannot accurately define HCC due to its short circulation lifetime and lack of tumor targeting specificity...
April 30, 2018: ACS Applied Materials & Interfaces
Cheng-Dong Qin, De-Ning Ma, Shi-Zhe Zhang, Ning Zhang, Zheng-Gang Ren, Xiao-Dong Zhu, Qing-An Jia, Zong-Tao Chai, Cheng-Hao Wang, Hui-Chuan Sun, Zhao-You Tang
Rnd1, a member of Rho GTPases, was found to be downregulated in human malignancies and downregulation of Rnd1 promotes tumor invasion via various mechanisms. However, the role of Rnd1 in hepatocellular carcinoma (HCC) progression remains unclear. In this study, our results demonstrated that Rnd1 was downregulated in HCC cells and in human HCC tissues. Low expression of Rnd1 was associated with aggressive clinic-pathologic characteristics, such as vascular invasion, and poor prognosis in patients who underwent curative surgery for HCC...
April 30, 2018: Cell Death & Disease
Stefania Brozzetti, Simone Bini, Katia Fazzi, Leonardo Luca Chiarella, Virginia Ceccarossi, Chiara De Lucia, Giorgio De Toma
INTRODUCTION: Hepatocellular carcinoma (HCC) is rare in non-cirrhotic liver. Achievement of sustained virological response (SVR) reduces even more the risk. PRESENTATION OF CASE: Liver resection for small HCC was performed in cleared HCV infection non-cirrhotic 62-year-old man. Methacronous oligometastatic recurrences in intolerant to Nexavar® side-effects patient, were treated by multiple innovative microinvasive approaches: bilateral laparoscopic adrenalectomy, thoracic wall resection, laparoscopic sacrum cryoablation combined with hadron-therapy...
April 22, 2018: International Journal of Surgery Case Reports
Jingzhou Mu, Qiuyu Chen, Liang Zhu, Yunhong Wu, Suping Liu, Yufei Zhao, Tonghui Ma
Liver transplantation is currently a standard therapy for patients with end-stage liver diseases and hepatocellular carcinoma. Given that liver transplantation has undergone a thriving development in these decades, the survival rates after liver transplantation have markedly improved as a result of the critical advancement in surgical techniques, immunosuppressive therapies, and postoperative care. However, infection remains a fatal complication after liver transplantation surgery. In particular, enterogenic infection represents a major complication in liver transplant recipients...
April 27, 2018: Current Medical Research and Opinion
Woo-Hyoung Kang, Ki-Hun Kim, Dong-Hwan Jung, Gil-Chun Park, Seok-Hwan Kim, Hwui-Dong Cho, Sung-Gyu Lee
BACKGROUND: Liver resection is a potentially curative therapy for hepatocellular carcinoma (HCC). LLR is a newly developed and safe technique associated with shorter hospital stay, less pain, better cosmetic outcomes, and similar complication rates as open surgery; however, data on its long-term outcomes remain scarce. METHODS: We retrospectively examined the clinical and follow-up data of 234 patients who underwent LLR (performed by a single surgeon in all cases) for the primary treatment of HCC between July 2007 and December 2015 at Asan Medical Center...
April 24, 2018: Surgical Endoscopy
Ke Chen, Yu Pan, Bin Zhang, Xiao-Long Liu, Hendi Maher, Xue-Yong Zheng
Objective: To present a meta-analysis of high-quality case-matched studies comparing laparoscopic (LH) and open hepatectomy (OH) for hepatocellular carcinoma (HCC). Methods: Studies published up to September 2017 comparing LH and OH for HCC were identified. Selection of high-quality, nonrandomized comparative studies (NRCTs) with case-matched design was based on a validated tool (Methodological Index for Nonrandomized Studies) since no randomized controlled trials (RCTs) were published...
2018: Canadian Journal of Gastroenterology & Hepatology
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