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Hepatocellular carcinoma surgery

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https://www.readbyqxmd.com/read/27909629/stereotactic-body-radiotherapy-for-hepatocellular-carcinoma-resulting-in-a-durable-relapse-free-survival-a-case-report
#1
Samual Francis, Ned Williams, Christopher J Anker, Akram Shaaban, Robin Kim, Dennis Shrieve, Jonathan Tward
The standard of care for localized hepatocellular carcinoma (HCC) is surgical resection. For patients who decline or who are unfit for surgery, stereotactic body radiotherapy (SBRT) is emerging as a viable treatment approach. We present a case of a 77-year-old female in whom an early stage HCC was incidentally discovered. Given her religious edicts as a devout Jehovah's Witness and her subsequent desire to avoid a blood transfusion, she declined surgical resection or transplant due to the risk of hemorrhage...
October 24, 2016: Curēus
https://www.readbyqxmd.com/read/27895416/practice-guidelines-for-the-pathological-diagnosis-of-primary-liver-cancer-2015-update
#2
REVIEW
Wen-Ming Cong, Hong Bu, Jie Chen, Hui Dong, Yu-Yao Zhu, Long-Hai Feng, Jun Chen, Guideline Committee
In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies (including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma (SHCC), microvascular invasion (MVI), satellite nodules, and immunohistochemical and molecular diagnosis...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27895410/collision-tumor-of-hepatocellular-carcinoma-and-neuroendocrine-carcinoma-involving-the-liver-case-report-and-review-of-the-literature
#3
Gyu Ho Choi, Sun Young Ann, Soon Il Lee, Suk Bae Kim, Il Han Song
Primary hepatic neuroendocrine carcinoma (NEC) with concurrent occurrence of hepatocellular carcinoma (HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional patterns; only 2 cases have been reported. Herein, we report a case of collision type concurrent occurrence of HCC and NEC, in which primary hepatic NEC was in only a small portion of the nodule, which is different from the 2 previously reported cases...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27878570/synchronous-double-cancers-of-primary-hepatocellular-carcinoma-and-cholangiolocellular-carcinoma-a-case-report
#4
Kazuhiro Suzumura, Yasukane Asano, Tadamichi Hirano, Toshihiro Okada, Naoki Uyama, Nobuhiro Aizawa, Hiroko Iijima, Keiji Nakasho, Shuhei Nishiguchi, Jiro Fujimoto
Synchronous double cancers consisting of hepatocellular carcinoma (HCC) and cholangiolocellular carcinoma (CoCC) are extremely rare. We herein report a surgical case of synchronous double cancers in a patient with primary HCC and CoCC. A 45-year-old man with hepatitis B was admitted to our hospital with hepatic tumors. The level of protein induced by vitamin K antagonist (PIVKA-II) was found to be elevated. Computed tomography (CT) revealed a 23-mm tumor with early-phase enhancement and late-phase washout in the 6th segment of the liver, and a 10-mm tumor with slight early-phase enhancement and late-phase washout in the 7th segment of the liver...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27878478/liver-resection-after-selective-internal-radiation-therapy-with-yttrium-90-is-safe-and-feasible-a-bi-institutional-analysis
#5
G Paul Wright, J Wallis Marsh, Manish K Varma, Michael G Doherty, David L Bartlett, Mathew H Chung
BACKGROUND: Treatment with yttrium-90 (Y90) microspheres has emerged as a viable liver-directed therapy for patients with unresectable tumors and those outside transplantation criteria. A select number of patients demonstrate a favorable response and become candidates for surgical resection. METHODS: Patients who underwent selective internal radiation therapy (SIRT) with Y90 microspheres at two institutions were reviewed. Patients who underwent liver resection were included in the study...
November 22, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27871552/preoperative-depressed-mood-and-perioperative-heart-rate-variability-in-patients-with-hepatic-cancer
#6
Eun-Hee Kim, Jin-Hyoung Park, Sangmin M Lee, Mi-Sook Gwak, Gaab-Soo Kim, Myung-Hee Kim
STUDY OBJECTIVE: How perioperative heart rate variability (HRV) indices differ according to the anxiety or depressed mood of patients scheduled to undergo a major surgical procedure for cancer. DESIGN: Prospective observational study. SETTING: Operating room. PATIENTS: Forty-one male patients between 40 and 70 years of age with hepatocellular carcinoma were included in the final analysis. INTERVENTIONS: HRV was measured on the day before surgery (T1), impending anesthesia (T2), and after anesthetic induction (T3)...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27871128/hand-assisted-laparoscopic-left-hepatectomy-how-i-do-it
#7
Susannah M Cheek, Iswanto Sucandy, David A Geller
Laparoscopic liver resection has been adopted slowly due to concerns for bleeding and oncologic outcomes. Currently, over 9,500 laparoscopic liver resections have been performed and reported worldwide. Numerous studies have shown the safety and oncologic equivalence of laparoscopic liver resection when compared to open resection. Pure laparoscopic and hand-assisted laparoscopic liver resection are the two most commonly used techniques for minimally invasive liver resection surgery. Advantages of the hand-port include tactile feedback, facilitation of liver mobilization, and ease of ability to control bleeding...
November 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27868101/simultaneous-retroperitoneal-robotic-partial-nephrectomy-and-hepatectomy-for-synchronous-renal-cell-carcinoma-and-hepatocellular-carcinoma-in-a-cirrhotic-patient
#8
Khaa Hoo Ong, Steven Kuan-Hua Huang, Chia-Sheng Yen, Yu-Feng Tian, Ding-Ping Sun
Background: The development of laparoscopic and robotic surgeries represents the modern era with the objective of improving patient outcomes; this surgical method is widespread in urology and general surgery. Retroperitoneal laparoscopic/robotic surgery is common in urologic surgery, but not in liver surgery. Tumors located in the posterosuperior aspect of the liver are difficult to access using a transperitoneal approach, and control of bleeding can also be difficult, especially in patients with cirrhosis...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27864870/hereditary-hemorrhagic-telangiectasia-to-transplant-or-not-to-transplant
#9
Sophie Dupuis-Girod, Elisabetta Buscarini
This report comments the case reported by Muller et al. which describes a combination of at least two different indications for orthotopic liver transplant (OLT) in a same patient: hepatocarcinoma and HHT complicated with severe liver involvement and high output cardiac failure. This case report highlighted that the clear time for OLT in HHT can be difficult to determine. In HHT, if intensive medical approach is not efficient, OLT, has to be considered. In the case of Muller et al., the patient was correctly listed for OLT for a single hepatocellular carcinoma, however, he did not receive a sufficient priority so as to avoid worsening of liver vascular malformations complications...
December 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27864623/simplified-hcc-art-score-for-highly-sensitive-detection-of-small-sized-and-early-stage-hepatocellular-carcinoma-in-the-widely-used-okuda-clip-and-bclc-staging-systems
#10
Abdelfattah M Attallah, Mohamed M Omran, Ahmed A Attallah, Mohamed A Abdelrazek, Khaled Farid, Ibrahim El-Dosoky
BACKGROUND: Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. METHODS: 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC...
November 18, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27863427/sorafenib-pretreatment-enhances-radiotherapy-through-targeting-mek-erk-nf-%C3%AE%C2%BAb-pathway-in-human-hepatocellular-carcinoma-bearing-mouse-model
#11
John Chun-Hao Chen, Hui-Yen Chuang, Fei-Ting Hsu, Yi-Chen Chen, Yi-Chun Chien, Jeng-Jong Hwang
Patients with unresectable hepatocellular carcinoma (HCC) usually have poor prognosis because current monotherapy including surgery, chemotherapy and radiotherapy (RT) are not effective. Combination therapy may be effective to overcome this clinical problem. Here, we proposed the combination of sorafenib and RT, which have been applied in HCC treatment, could improve the treatment outcome of HCC. Our previous study showed that sorafenib could suppress the expression of NF-κB which is related to the chemo- and radio-resistance...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27858885/effect-of-surgical-margin-in-r0-hepatectomy-on-recurrence-free-survival-of-patients-with-solitary-hepatocellular-carcinomas-without-macroscopic-vascular-invasion
#12
Sheng Dong, Zusen Wang, Liqun Wu, Zhiqiang Qu
The study aimed to investigate the impact of different surgical margins on recurrence-free survival (RFS) of patients with solitary hepatocellular carcinoma (HCC) without macroscopic vascular invasion.The data of 586 selected patients who underwent curative hepatectomy for HCC between 2001 and 2012 were analyzed. The patients were divided into the anatomic resection and the nonanatomic resection groups according to the surgical approaches. Each group was further divided into group A (surgical margin <5 mm), group B (5 mm ≤ surgical margin < 10 mm), and group C (surgical margin ≥10 mm)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27853648/endothelial-progenitor-cell-number-and-erk-phosphorylation-serve-as-predictive-and-prognostic-biomarkers-in-advanced-hepatocellular-carcinoma-patients-treated-with-sorafenib
#13
Suresh Gopi Kalathil, Amit Anand Lugade, Renuka Iyer, Austin Miller, Yasmin Thanavala
Sorafenib is an oral anti-angiogenic multi-kinase inhibitor used for systemic therapy in patients with advanced hepatocellular carcinoma (HCC) who are not suitable candidates for surgery or liver transplantation. An earlier study conducted with HCC tumor tissue suggested that ERK phosphorylation (pERK), a downstream target of sorafenib, may serve as a potential biomarker for therapeutic efficacy of sorafenib. However, no study thus far has utilized a minimal invasive procedure to predict HCC patient responsiveness to sorafenib...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27835570/prognostic-nutritional-index-predicts-short-term-outcomes-after-liver-resection-for-hepatocellular-carcinoma-within-the-milan-criteria
#14
Mengyun Ke, Tao Xu, Na Li, Yifan Ren, Aihua Shi, Yi Lv, Haiqi He
BACKGROUND: The prognostic nutritional index (PNI) is calculated based on the serum albumin concentration and the total lymphocyte count. The aim of this study was to investigate the prognostic ability of the PNI for postoperative complications after liver resection to treat hepatocellular carcinoma (HCC) within the Milan criteria. RESULTS: Postoperative complications were observed in 166 (44.6%) patients. The optimal cutoff value of the PNI was set at 45.6 for postoperative complications...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832038/improving-prognosis-for-patients-with-hepatocellular-carcinoma-in-ireland-1994-2008
#15
Caroline Gaynor, Masood Iqbal, Harry Comber, Sandra Deady, Aiden McCormick
OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) is increasing in low-prevalence countries such as the USA, UK and Ireland. Over the past two decades, diagnostic techniques have improved and new treatments have been introduced. The aim of this study was to determine whether there has been an impact on hepatoma mortality in Ireland. METHODS: Anonymized cancer registration data from the National Cancer Registry of Ireland were used to investigate patient characteristics and trends in treatment and survival for Irish patients diagnosed with histologically confirmed HCC between 1994 and 2008...
November 9, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27829060/comprehensive-comparison-of-multiple-detector-computed-tomography-and-dynamic-magnetic-resonance-imaging-in-the-diagnosis-of-hepatocellular-carcinoma-with-varying-degrees-of-fibrosis
#16
Ming-Tsung Lin, Chih-Chi Wang, Yu-Fan Cheng, Hock-Liew Eng, Yi-Hao Yen, Ming-Chao Tsai, Po-Lin Tseng, Kuo-Chin Chang, Cheng-Kun Wu, Tsung-Hui Hu
BACKGROUND & AIMS: Liver computed tomography and dynamic magnetic resonance imaging play an important role in the early detection of hepatocellular carcinoma. However, the American Association for the Study of Liver Diseases (AASLD) recommend the use of applied imaging studies for HCC diagnosis only in cirrhotic patients. This study aimed to comprehensively compare liver CT and dynamic MRI for HCC diagnosis before surgical resection over years in clinical practice, and also to compare the diagnostic differences between liver CT and dynamic MRI in HCCs with varying degrees of fibrosis...
2016: PloS One
https://www.readbyqxmd.com/read/27818595/cyclooxygenase-2-expression-is-associated-with-initiation-of-hepatocellular-carcinoma-while-prostaglandin-receptor-1-expression-predicts-survival
#17
Hao-Jie Yang, Jing-Hang Jiang, Yu-Ting Yang, Xiang-Di Yang, Zhe Guo, Ya-Peng Qi, Feng-Hua Zeng, Ke-Lan Zhang, Neng-Zhi Chen, Bang-De Xiang, Le-Qun Li
AIM: To determine whether cyclooxygenase-2 (COX-2) and prostaglandin E1 receptor (EP1) contribute to disease and whether they help predict prognosis. METHODS: We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma (HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffin-embedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were determined...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27818593/macrophage-colony-stimulating-factor-expressed-in-non-cancer-tissues-provides-predictive-powers-for-recurrence-in-hepatocellular-carcinoma
#18
Hiroshi Kono, Hideki Fujii, Shinji Furuya, Michio Hara, Kazuyoshi Hirayama, Yoshihiro Akazawa, Yuuki Nakata, Masato Tsuchiya, Naohiro Hosomura, Chao Sun
AIM: To investigate the role of macrophage colony-stimulating factor (M-CSF) in patients with hepatocellular carcinoma (HCC) after surgery. METHODS: Expression of M-CSF, distribution of M2 macrophages (MΦs), and angiogenesis were assessed in the liver, including tumors and peritumoral liver tissues. The prognostic power of these factors was assessed. Mouse isolated hepatic MΦs or monocytes were cultured with media containing M-CSF. The concentration of vascular endothelial growth factor (VEGF) in media was assessed...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27815759/distinct-recurrence-risk-factors-for-intrahepatic-metastasis-and-multicenter-occurrence-after-surgery-in-patients-with-hepatocellular-carcinoma
#19
Shenghua Hao, Ping Fan, Shaofei Chen, Caixue Tu, Chidan Wan
BACKGROUND AND OBJECTIVES: Intrahepatic recurrence after hepatectomy for hepatocellular carcinoma (HCC) includes intrahepatic metastasis (IM) and multicenter occurrence (MO). The risk factors for these two types of intrahepatic recurrence have not been well defined. METHODS: The type of intrahepatic recurrence was determined based on histopathological features of 93 HCC patients who underwent a repeat hepatectomy for recurrent HCC. Various clinical and pathological factors were analyzed to define distinct risk factors for different types of intrahepatic recurrence...
November 4, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27813096/real-time-confocal-laser-endomicroscopic-evaluation-of-primary-liver-cancer-based-on-human-liver-autofluorescence
#20
Harufumi Maki, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasushi Harihara, Norihiro Kokudo
BACKGROUND: Confocal laser endomicroscopy (CLE) is available for real-time microscopic examination. This study aims to evaluate the usefulness of intraoperative CLE examination as a modality to evaluate surgical margins in surgery for primary liver cancer. METHODS: A probe-based CLE system (Cellvizio 100, Mauna Kea Technologies, Paris, France) was used. The subjects comprised seven specimens obtained from six patients with primary liver cancer in November 2015. The probe was manually attached to the surfaces of specimens, and images were collected without external fluorophores...
November 4, 2016: Journal of Surgical Oncology
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