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https://www.readbyqxmd.com/read/28651575/ontological-interpretation-of-biomedical-database-content
#1
Filipe Santana da Silva, Ludger Jansen, Fred Freitas, Stefan Schulz
BACKGROUND: Biological databases store data about laboratory experiments, together with semantic annotations, in order to support data aggregation and retrieval. The exact meaning of such annotations in the context of a database record is often ambiguous. We address this problem by grounding implicit and explicit database content in a formal-ontological framework. METHODS: By using a typical extract from the databases UniProt and Ensembl, annotated with content from GO, PR, ChEBI and NCBI Taxonomy, we created four ontological models (in OWL), which generate explicit, distinct interpretations under the BioTopLite2 (BTL2) upper-level ontology...
June 26, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28649660/how-do-we-increase-uptake-of-tamoxifen-and-other-anti-estrogens-for-breast-cancer-prevention
#2
Katherine D Crew, Kathy S Albain, Dawn L Hershman, Joseph M Unger, Shelly S Lo
Several randomized controlled trials of anti-estrogens, such as tamoxifen and aromatase inhibitors, have demonstrated up to a 50-65% decrease in breast cancerincidence among high-risk women. Approximately 15% of women, age 35-79 years, in the U.S. meet criteria for breast cancer preventive therapies, but uptake of these medications remain low. Explanations for this low uptake includelack of awareness of breast cancer risk status, insufficient knowledge about breast cancer preventive therapies among patients and physicians, and toxicity concerns...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28648571/the-neuro-cognitive-representations-of-symbols-the-case-of-concrete-words
#3
Valentina Borghesani, Manuela Piazza
We live our lives surrounded by symbols (e.g., road signs, logos, but especially words and numbers), and throughout our life we use them to evoke, communicate and reflect upon ideas and things that are not currently present to our senses. Symbols are represented in our brains at different levels of complexity: at the first and most simple level, as physical entities, in the corresponding primary and secondary sensory cortices. The crucial property of symbols, however, is that, despite the simplicity of their surface forms, they have the power of evoking higher order multifaceted representations that are implemented in distributed neural networks spanning a large portion of the cortex...
June 22, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28647496/a-comprehensive-complex-systems-approach-to-the-study-and-analysis-of-mammalian-cell-cycle-control-system-in-the-presence-of-dna-damage-stress
#4
Ali Abroudi, Sandhya Samarasinghe, Don Kulasiri
Not many models of mammalian cell cycle system exist due to its complexity. Some models are too complex and hard to understand, while some others are too simple and not comprehensive enough. Moreover, some essential aspects, such as the response of G1-S and G2-M checkpoints to DNA damage as well as the growth factor signalling, have not been investigated from a systems point of view in current mammalian cell cycle models. To address these issues, we bring a holistic perspective to cell cycle by mathematically modelling it as a complex system consisting of important sub-systems that interact with each other...
June 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28642792/infection-control-measures-in-private-dental-clinics-in-lebanon
#5
Jihad Dagher, Charles Sfeir, Ahmad Abdallah, Zeina Majzoub
PURPOSE: Evaluate infection control knowledge, attitude, and practice in Lebanese private dental clinics. MATERIALS AND METHODS: A survey including 46 questions related to routine safety procedures was sent to 1150 Lebanese dentists between July 1st and 2nd, 2015. The study sample was selected from the database of registered dentists based on a proportional random sampling ensuring equitable representation of the 5 geographic regions of Lebanon. A subset of 29 questions was used to generate an overall score of compliance (excellent, good, fair, and poor)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28642721/simulation-theory-applied-to-direct-systematic-observation
#6
Rumen Manolov, José L Losada
Observational studies entail making several decisions before data collection, such as the observational design to use, the sampling of sessions within the observational period, the need for time sampling within the observation sessions, as well as the observation recording procedures to use. The focus of the present article is on observational recording procedures different from continuous recording (i.e., momentary time sampling, partial and whole interval recording). The main aim is to develop an online software application, constructed using R and the Shiny package, on the basis of simulations using the alternating renewal process (a model implemented in the ARPobservation package)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28641242/arrhythmia-mechanism-and-scaling-effect-on-the-spectral-properties-of-electroanatomical-maps-with-manifold-harmonics
#7
Margarita Sanroman-Junquera, Inmaculada Mora-Jimenez, Arcadi Garcia-Alberola, Antonio J Caamano, Beatriz Trenor, Jose Luis Rojo-Alvarez
Spatial and temporal processing of intracardiac electrograms provides relevant information to support the arrhythmia ablation during electrophysiological studies. Current Cardiac Navigation Systems (CNS) and Electrocardiographic Imaging (ECGI) build detailed three-dimensional electroanatomical maps (EAM), which represent the spatial anatomical distribution of bioelectrical features, such as activation time or voltage. We present a principled methodology for spectral analysis of both EAM geometry and bioelectrical feature in CNS or ECGI, including their spectral representation, cut-off frequency, or spatial sampling rate (SSR)...
June 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28640543/evolutionary-optimized-photonic-network-structure-in-white-beetle-wing-scales
#8
Bodo D Wilts, Xiaoyuan Sheng, Mirko Holler, Ana Diaz, Manuel Guizar-Sicairos, Jörg Raabe, Robert Hoppe, Shu-Hao Liu, Richard Langford, Olimpia D Onelli, Duyu Chen, Salvatore Torquato, Ullrich Steiner, Christian G Schroer, Silvia Vignolini, Alessandro Sepe
Most studies of structural color in nature concern periodic arrays, which through the interference of light create color. The "color" white however relies on the multiple scattering of light within a randomly structured medium, which randomizes the direction and phase of incident light. Opaque white materials therefore must be much thicker than periodic structures. It is known that flying insects create "white" in extremely thin layers. This raises the question, whether evolution has optimized the wing scale morphology for white reflection at a minimum material use...
June 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28640353/ecology-of-the-non-native-snail-sinotaia-cf-quadrata-caenogastropoda-viviparidae-a-study-in-a-lowland-stream-of-south-america-with-different-water-qualities
#9
Ana Clara Ferreira, Estefanía L Paz, Alejandra Rumi, Carolina Ocon, Paula Altieri, Alberto Rodrigues Capítulo
Sinotaia quadrata is a snail native from Asia recorded for the first time in South America in 2009 in central Argentina. In 2015, this species was also found in a lowland stream with different water qualities. Our aims were to contribute to the knowledge of its population ecology and to compare the individuals from the two locations anatomically. Snails were searched at 6 sites, where physicochemical and hydraulic parameters were measured. Biological samples were also taken at two sites (S3 and S4) to study the population traits of S...
April 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28638974/categorical-templates-are-more-useful-when-features-are-consistent-evidence-from-eye-movements-during-search-for-societally-important-vehicles
#10
Michael C Hout, Arryn Robbins, Hayward J Godwin, Gemma Fitzsimmons, Collin Scarince
Unlike in laboratory visual search tasks-wherein participants are typically presented with a pictorial representation of the item they are asked to seek out-in real-world searches, the observer rarely has veridical knowledge of the visual features that define their target. During categorical search, observers look for any instance of a categorically defined target (e.g., helping a family member look for their mobile phone). In these circumstances, people may not have information about noncritical features (e...
June 21, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28635107/new-space-time-metaphors-foster-new-nonlinguistic-representations
#11
Rose K Hendricks, Lera Boroditsky
What is the role of language in constructing knowledge? In this article, we ask whether learning new relational language can create new ways of thinking. In Experiment 1, we taught English speakers to talk about time using new vertical linguistic metaphors, saying things like "breakfast is above dinner" or "breakfast is below dinner" (depending on condition). In Experiment 2, rather than teaching people new metaphors, we relied on the left-right representations of time that our American college student participants have already internalized through a lifetime of visuospatial experience reading and writing text from left to right...
June 21, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28633446/genetic-indicators-of-drug-resistance-in-the-highly-repetitive-genome-of-trichomonas-vaginalis
#12
Martina Bradic, Sally D Warring, Grace E Tooley, Paul Scheid, William E Secor, Kirkwood M Land, Po-Jung Huang, Ting-Wen Chen, Chi-Ching Lee, Petrus Tang, Steven A Sullivan, Jane M Carlton
Trichomonas vaginalis, the most common non-viral sexually transmitted parasite, causes ∼283 million trichomoniasis infections annually and is associated with pregnancy complications and increased risk of HIV-1 acquisition. The antimicrobial drug metronidazole is used for treatment, but in a fraction of clinical cases, the parasites can become resistant to this drug. We undertook sequencing of multiple clinical isolates and lab derived lines to identify genetic markers and mechanisms of metronidazole resistance...
June 19, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28633173/exploring-residents-skills-in-diagnosing-dementia-the-unexpected-dissonance-between-ability-and-confidence
#13
Brian S Lerner, Virginia Kalish, Christy J W Ledford
BACKGROUND AND OBJECTIVES: The diagnosis of dementia is a challenge for physicians due to numerous interrelated barriers. Research shows that this difficulty may be rooted in an incomplete knowledge about dementia. To address this gap, we developed an assessment scale of resident confidence in the diagnosis of dementia and used it to compare resident confidence to their practical ability to diagnose dementia. METHODS: The study used a piloted confidence assessment tool for diagnosing dementia correlated with family medicine residents (n=45) performance during an objective structured clinical examination (OSCE)...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28630882/review-how-do-spontaneous-and-sensory-evoked-activities-interact
#14
REVIEW
Isabelle Ferezou, Thomas Deneux
Twenty years ago, the seminal work of Grinvald et al. revolutionized the view cast on spontaneous cortical activity by showing how, instead of being a mere measure of noise, it profoundly impacts cortical responses to a sensory input and therefore could play a role in sensory processing. This paved the way for a number of studies on the interactions between spontaneous and sensory-evoked activities. Spontaneous activity has subsequently been found to be highly structured and to participate in high cognitive functions, such as influencing conscious perception in humans...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28624644/psychiatric-symptom-recognition-without-labeled-data-using-distributional-representations-of-phrases-and-on-line-knowledge
#15
Yaoyun Zhang, Olivia Zhang, Yonghui Wu, Hee-Jin Lee, Jun Xu, Hua Xu, Kirk Roberts
OBJECTIVE: Mental health is becoming an increasingly important topic in healthcare. Psychiatric symptoms, which consist of subjective descriptions of the patient's experience, as well as the nature and severity of mental disorders, are critical to support the phenotypic classification for personalized prevention, diagnosis, and intervention of mental disorders. However, few automated approaches have been proposed to extract psychiatric symptoms from clinical text, mainly due to (a) the lack of annotated corpora, which are time-consuming and costly to build, and (b) the inherent linguistic difficulties that symptoms present as they are not well-defined clinical concepts like diseases...
June 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28623869/changing-predictions-stable-recognition-children-s-representations-of-downward-incline-motion
#16
Michael Hast, Christine Howe
Various studies to-date have demonstrated children hold ill-conceived expressed beliefs about the physical world such as that one ball will fall faster than another because it is heavier. At the same time, they also demonstrate accurate recognition of dynamic events. How these representations relate is still unresolved. This study examined 5- to 11-year-olds' (N = 130) predictions and recognition of motion down inclines. Predictions were typically in error, matching previous work, but children largely recognized correct events as correct and rejected incorrect ones...
June 17, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28621948/insight-into-the-am-o-phase-equilibria-a-thermodynamic-study-coupling-high-temperature-xrd-and-calphad-modeling
#17
Enrica Epifano, Christine Guéneau, Renaud C Belin, Romain Vauchy, Florent Lebreton, Jean-Christophe Richaud, Alexis Joly, Christophe Valot, Philippe M Martin
In the frame of minor actinide transmutation, americium can be diluted in UO2 and (U, Pu)O2 fuels burned in fast neutron reactors. The first mandatory step to foresee the influence of Am on the in-reactor behavior of transmutation targets or fuel is to have fundamental knowledge of the Am-O binary system and, in particular, of the AmO2-x phase. In this study, we coupled HT-XRD (high-temperature X-ray diffraction) experiments with CALPHAD thermodynamic modeling to provide new insights into the structural properties and phase equilibria in the AmO2-x-AmO1...
June 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28615794/deepinfer-open-source-deep-learning-deployment-toolkit-for-image-guided-therapy
#18
Alireza Mehrtash, Mehran Pesteie, Jorden Hetherington, Peter A Behringer, Tina Kapur, William M Wells, Robert Rohling, Andriy Fedorov, Purang Abolmaesumi
Deep learning models have outperformed some of the previous state-of-the-art approaches in medical image analysis. Instead of using hand-engineered features, deep models attempt to automatically extract hierarchical representations at multiple levels of abstraction from the data. Therefore, deep models are usually considered to be more flexible and robust solutions for image analysis problems compared to conventional computer vision models. They have demonstrated significant improvements in computer-aided diagnosis and automatic medical image analysis applied to such tasks as image segmentation, classification and registration...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28615342/supramodal-representation-of-temporal-priors-calibrates-interval-timing
#19
Huihui Zhang, Xiaolin Zhou
Human timing behaviors are consistent with Bayesian inference, according to which both previous knowledge (prior) and current sensory information determine final responses. However, it is unclear whether the brain represents temporal priors exclusively for individual modalities or in a supramodal manner when temporal information comes from different modalities at different times. Here we asked participants to reproduce time intervals in either a unisensory or a multisensory context. In unisensory tasks, sample intervals drawn from a uniform distribution were presented in a single visual or auditory modality...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28615003/3d-deep-convolutional-neural-networks-for-amino-acid-environment-similarity-analysis
#20
Wen Torng, Russ B Altman
BACKGROUND: Central to protein biology is the understanding of how structural elements give rise to observed function. The surfeit of protein structural data enables development of computational methods to systematically derive rules governing structural-functional relationships. However, performance of these methods depends critically on the choice of protein structural representation. Most current methods rely on features that are manually selected based on knowledge about protein structures...
June 14, 2017: BMC Bioinformatics
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