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https://www.readbyqxmd.com/read/28314465/data-capture-and-communication-during-transfers-to-definitive-care-in-an-inclusive-trauma-system
#1
Nori L Bradley, Naisan Garraway, Nathaniel Bell, Nasira Lakha, S Morad Hameed
INTRODUCTION: Background trauma survivors in rural areas transferred to urban centers have higher mortality than trauma patients admitted directly to urban centers. Transfer data in trauma registries is important for injury control. Prehospital and early physiologic data may reflect processes of pre-hospital care. British Columbia currently has no standardized process for trauma patient data transfer. PATIENTS AND METHODS: We performed a retrospective data analysis for major trauma patients (ISS>15) transferred to a Level I trauma center over a 1year period (n=243)...
November 5, 2016: Injury
https://www.readbyqxmd.com/read/28289422/gene-mining-for-proline-based-signaling-proteins-in-cell-wall-of-arabidopsis-thaliana
#2
REVIEW
Muhammad Z Ihsan, Samina J N Ahmad, Zahid Hussain Shah, Hafiz M Rehman, Zubair Aslam, Ishita Ahuja, Atle M Bones, Jam N Ahmad
The cell wall (CW) as a first line of defense against biotic and abiotic stresses is of primary importance in plant biology. The proteins associated with cell walls play a significant role in determining a plant's sustainability to adverse environmental conditions. In this work, the genes encoding cell wall proteins (CWPs) in Arabidopsis were identified and functionally classified using geneMANIA and GENEVESTIGATOR with published microarrays data. This yielded 1605 genes, out of which 58 genes encoded proline-rich proteins (PRPs) and glycine-rich proteins (GRPs)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28289200/dynamic-neural-architecture-for-social-knowledge-retrieval
#3
Yin Wang, Jessica A Collins, Jessica Koski, Tehila Nugiel, Athanasia Metoki, Ingrid R Olson
Social behavior is often shaped by the rich storehouse of biographical information that we hold for other people. In our daily life, we rapidly and flexibly retrieve a host of biographical details about individuals in our social network, which often guide our decisions as we navigate complex social interactions. Even abstract traits associated with an individual, such as their political affiliation, can cue a rich cascade of person-specific knowledge. Here, we asked whether the anterior temporal lobe (ATL) serves as a hub for a distributed neural circuit that represents person knowledge...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28289031/downregulation-of-autolysin-encoding-genes-by-phage-derived-lytic-proteins-inhibits-biofilm-formation-in-staphylococcus-aureus
#4
Lucía Fernández, Silvia González, Ana Belén Campelo, Beatriz Martínez, Ana Rodríguez, Pilar García
Phage-derived lytic proteins are a promising alternative to conventional antimicrobials. One of their most interesting properties is that they do not readily select for resistant strains, which is likely due to the fact that their targets are essential for the viability of the bacterial cell. Moreover, genetic engineering allows the design of new "tailor-made" proteins that may exhibit improved antibacterial properties. One example of this is the chimeric protein CHAPSH3b, which consists of a catalytic domain from the virion-associated peptidoglycan (PG) hydrolase of phage vB_SauS-phiIPLA88 (HydH5) and the cell wall binding domain of lysostaphin...
March 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28284648/the-relative-risk-and-its-distribution-of-endocrine-disrupting-chemicals-pharmaceuticals-and-personal-care-products-to-freshwater-organisms-in-the-bohai-rim-china
#5
Meng Zhang, Yajuan Shi, Yonglong Lu, Andrew C Johnson, Suriyanarayanan Sarvajayakesavalu, Zhaoyang Liu, Chao Su, Yueqing Zhang, Monika D Juergens, Xiaowei Jin
In this study, the risks to aquatic organisms posed by 12 commonly detected pharmaceuticals and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) that are extensively used in Bohai coastal region of China were examined. These were linear alkylbenzene sulfonate (LAS), nonylphenol (NP), diethylhexyl phthalate (DEHP), norfloxacin (NOR), sulfamethoxazole (SMX), erythromycin (ERY), bisphenol A (BPA), ofloxacin (OFL), carbamazepine (CBZ), naproxen (NPX), atenolol (ATL) and metoprolol (MET)...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28282218/immunotoxins-in-cancer-therapy-review-and-update
#6
Bahman Akbari, Safar Farajnia, Shiva Ahdi Khosroshahi, Fatemeh Safari, Mohammadreza Yousefi, Hassan Dariushnejad, Leila Rahbarnia
Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused to a targeting moiety. Various toxic agents from different sources are used in immunotoxin development, including bacterial, plant and human origin cytotoxic elements. Although bacterial and plant-derived toxins are highly toxic and commonly used in immunotoxins, their immunogenicity for human restricted their application in cancer therapy. Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes...
March 1, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28278170/rapid-on-line-detection-and-grading-of-wooden-breast-myopathy-in-chicken-fillets-by-near-infrared-spectroscopy
#7
Jens Petter Wold, Eva Veiseth-Kent, Vibeke Høst, Atle Løvland
The main objective of this work was to develop a method for rapid and non-destructive detection and grading of wooden breast (WB) syndrome in chicken breast fillets. Near-infrared (NIR) spectroscopy was chosen as detection method, and an industrial NIR scanner was applied and tested for large scale on-line detection of the syndrome. Two approaches were evaluated for discrimination of WB fillets: 1) Linear discriminant analysis based on NIR spectra only, and 2) a regression model for protein was made based on NIR spectra and the estimated concentrations of protein were used for discrimination...
2017: PloS One
https://www.readbyqxmd.com/read/28273722/a-theoretical-framework-for-determining-cerebral-vascular-function-and-heterogeneity-from-dynamic-susceptibility-contrast-mri
#8
Ingrid Digernes, Atle Bjørnerud, Svein Are S Vatnehol, Grete Løvland, Frédéric Courivaud, Einar Vik-Mo, Torstein R Meling, Kyrre E Emblem
Mapping the complex heterogeneity of vascular tissue in the brain is important for understanding cerebrovascular disease. In this translational study, we build on previous work using vessel architectural imaging (VAI) and present a theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast magnetic resonance imaging (MRI). Our tissue model covers realistic structural architectures for vessel branching and orientations, as well as a range of hemodynamic scenarios for blood flow, capillary transit times and oxygenation...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28273219/evaluation-of-care-for-traffic-accidents-victims-made-by-on-duty-emergency-physicians-and-surgeons-in-the-emergency-room
#9
Vlaudimir Dias Marques, Mauricio Medeiros Lemos, Cesar Orlando Peralta Bandeira, Amélia Cristina Seidel, Sandra Maria Peloso, Maria Dalva DE Barros Carvalho
OBJECTIVE: to evaluate the care for victims of traffic accidents by on call emergency physicians and/or surgeons in the emergency room. METHODS: we conducted a retrospective, descriptive and exploratory study on the care for traffic accidents victims in the urban area of ​​Maringá-PR, between July 2013 and July 2014 in reference hospitals. We assessed demographics and vocational training through a questionnaire sent to the attending physicians. RESULTS: of the 688 records evaluated, 99% of patients had a prehospital Revised Trauma Score of 12...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28272555/forgetful-and-forgotten
#10
Tor Atle Rosness
No abstract text is available yet for this article.
March 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28269998/htlv-infection-in-hcv-antibody-positive-patients-in-spain
#11
Ana Treviño, Antonio Aguilera, Manuel A Rodríguez-Iglesias, Araceli Hernandez, Rafael Benito, Lourdes Roc, José Manuel Ramos, Raúl Ortíz de Lejarazu, Eva Poveda, Carmen Rodríguez, Jorge Del Romero, Enrique Calderon, Juan García, Silvia Requena, Vincent Soriano, Carmen de Mendoza
Since hepatitis C virus (HCV) and human T-lymphotropic virus (HTLV) share transmission routes, dual infection could be frequent. In Spain, HTLV underdiagnosis is highlighted by the high proportion of patients presenting either with tropical spastic paraparesis (TSP) or adult T-cell leukemia (ATL) at first diagnosis. We examined whether the renewed efforts for expanding HCV testing may provide a sentinel population that might selectively be targeted to unveil asymptomatic HTLV carriers. The presence of anti-HTLV antibodies was examined in 3,838 consecutive individuals with reactive HCV serology attended during the last three years at 13 hospitals distributed across the Spanish geography...
March 7, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28263674/human-t-cell-leukemia-virus-type-1-and-eye-diseases
#12
Yukiko Terada, Koju Kamoi, Takashi Komizo, Kazunori Miyata, Manabu Mochizuki
Human T cell leukemia virus type 1, also known as human T lymphotropic virus type 1 (HTLV-1), is a retrovirus that encodes a reverse transcriptase, which translates viral RNA into a DNA provirus that is integrated into the host genome. The virus was found to be a causative agent of adult T cell leukemia/lymphoma (ATL) in the early 1980s, and was also found to cause the neurological disorder tropical spastic paraparesis (TSP)/HTLV-1-associated myelopathy (HAM) and the inflammatory disorder HTLV-1 uveitis in the mid 1980s and early 1990s, respectively...
March 1, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28262283/demand-for-specialised-training-for-the-obese-trauma-patient-national-atls-expert-group-survey-results
#13
Philip H Pucher, Lulu Tanno, Kalon Hewage, N Mark Bagnall
BACKGROUND: The growing incidence of obesity in Western populations continues to place new stressors on health systems. Obese trauma patients present particular challenges across the entirety of the patient care pathway, and are at risk of higher lengths of stay, morbidity, and mortality. This study sought to assess a national group of trauma experts' opinions and knowledge regarding the management of obese trauma. METHODS: A questionnaire was circulated to a trauma training providers and national steering committee members at a UK national Advance Trauma Life Support meeting...
February 24, 2017: Injury
https://www.readbyqxmd.com/read/28262203/development-and-evaluation-of-a-trauma-decision-making-simulator-in-oculus-virtual-reality
#14
Cuan M Harrington, Dara O Kavanagh, John F Quinlan, Donncha Ryan, Patrick Dicker, Dara O'Keeffe, Oscar Traynor, Sean Tierney
BACKGROUND: Consumer-available virtual-reality technology was launched in 2016 with strong foundations in the entertainment-industry. We developed an innovative medical-training simulator on the Oculus™ Gear-VR platform. This novel application was developed utilising internationally recognised Advanced Trauma Life Support (ATLS) principles, requiring decision-making skills for critically-injured virtual-patients. METHODS: Participants were recruited in June, 2016 at a single-centre trauma-course (ATLS, Leinster, Ireland) and trialled the platform...
February 10, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28261958/rate-of-positive-autoimmune-markers-in-human-t-lymphotropic-virus-type-1-carriers-a-case-control-study-from-iran
#15
Sanaz Ahmadi Ghezeldasht, Mohammad Reza Hedayati-Moghaddam, Meysam Habibi, Farzad Mollahosseini, Houshang Rafatpanah, Rahele Miri, MohammadReza Hatef Fard, Maryam Sahebari
AIM: Human T lymphotropic virus type 1 (HTLV-1) infection with high prevalence in the north-east of Iran, particularly in Mashhad, can lead to adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and a variety of autoimmune diseases. The aim of the study was to examine the presence of autoimmune markers in HTLV carries. METHODS: Serum samples were obtained from blood donors in Mashhad, northeastern Iran. One hundred and five HTLV-1 positive (cases) and 104 age- and sex-matched HTLV-1 negative donors (controls) were assessed for presence of serum autoimmune markers by enzyme-linked immunosorbent assay...
March 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28261198/a-fas-hi-lymphoproliferative-phenotype-reveals-non-apoptotic-fas-signaling-in-htlv-1-associated-neuroinflammation
#16
Soraya Maria Menezes, Fabio E Leal, Tim Dierckx, Ricardo Khouri, Daniele Decanine, Gilvaneia Silva-Santos, Saul V Schnitman, Ramon Kruschewsky, Giovanni López, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Douglas F Nixon, Jurgen Vercauteren, David Brassat, Roland Liblau, Anne Mieke Vandamme, Bernardo Galvão-Castro, Johan Van Weyenbergh
Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been associated to both ATL and HAM/TSP susceptibility. Fas(hi) T stem cell memory (Tscm) cells have been identified as the hierarchical apex of ATL, but have not been investigated in HAM/TSP...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28260789/hbz-mediated-shift-of-jund-from-growth-suppressor-to-tumor-promoter-in-leukemic-cells-by-inhibition-of-ribosomal-protein-s25-expression
#17
M Terol, H Gazon, I Lemasson, M Duc Dodon, B Barbeau, R Césaire, J-M Mesnard, J-M Péloponèse
HTLV-1 bZIP factor (HBZ) is a key player in proliferation and transformation of HTLV-1-infected cells, thus contributing to ATL development. HBZ deregulates gene expression within the host cell by interacting with several cellular partners. Through its C-terminal ZIP domain, HBZ is able to contact and activate JunD, a transcription factor of the AP-1 family. jund mRNA is intronless but can generate two protein isoforms by alternative translation initiation: JunD full-length and ΔJunD, an N-terminal truncated form unresponsive to the tumor suppressor menin...
March 6, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28253686/analysis-of-acoustic-impedance-matching-in-dual-band-ultrasound-transducers
#18
Ola Finneng Myhre, Tonni Franke Johansen, Bjørn Atle Johan Angelsen
Dual-frequency band probes are needed for ultrasound (US) reverberation suppression and are useful for image-guided US therapy. A challenge is to design transducer stacks that achieve high bandwidth and efficiency at both operating frequencies when the frequencies are widely separated with a frequency ratio ∼6:1-20:1. This paper studies the loading and backing conditions of transducers in such stacks. Three stack configurations are presented and analyzed using one-dimensional models. It is shown that a configuration with three layers of material separating the transducers is favorable, as it reduces high frequency ringing by ∼20 dB compared to other designs, and matches the low frequency (LF) transducer to the load at a lower frequency...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28252206/analysis-of-htlv-1-proviral-load-pvl-and-antibody-detected-with-various-kinds-of-tests-in-japanese-blood-donors-to-understand-the-relationship-between-pvl-and-antibody-level-and-to-gain-insights-towards-better-antibody-testing
#19
Chieko Matsumoto, Yasuko Sagara, Rieko Sobata, Yukiko Inoue, Maiko Morita, Shigeharu Uchida, Hiroyuki Kiyokawa, Masahiro Satake, Kenji Tadokoro
Adult T-cell leukemia/lymphoma (ATL) occurs in approximately 5% of individuals infected with human T-cell leukemia virus type 1 (HTLV-1). A high proviral load (PVL; more than 4 copies per 100 peripheral blood mononuclear cells (PBMCs) or 1.6 copies per 100 blood leukocytes) and being male are risk factors for ATL development. Whether anti-HTLV-1 antibody level is related to such risk is unknown. Here, PVL and antibody levels were examined using real-time PCR and other tests in 600 HTLV-1 positive screened Japanese blood donors to understand the relationship between PVL and antibody level in asymptomatic carriers and to gain insights towards better antibody testing for HTLV-1 infection...
March 2, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28250957/the-mechanism-behind-the-selection-of-two-different-cleavage-sites-in-nag-nam-polymers
#20
Marko Mihelič, Kristina Vlahoviček-Kahlina, Miha Renko, Stephane Mesnage, Andreja Doberšek, Ajda Taler-Verčič, Andreja Jakas, Dušan Turk
Peptidoglycan is a giant molecule that forms the cell wall that surrounds bacterial cells. It is composed of alternating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) residues connected by β-(1,4)-glycosidic bonds and cross-linked with short polypeptide chains. Owing to the increasing antibiotic resistance against drugs targeting peptidoglycan synthesis, studies of enzymes involved in the degradation of peptidoglycan, such as N-acetylglucos-aminidases, may expose new, valuable drug targets. The scientific challenge addressed here is how lysozymes, muramidases which are likely to be the most studied enzymes ever, and bacterial N-acetylglucosaminidases discriminate between two glycosidic bonds that are different in sequence yet chemically equivalent in the same NAG-NAM polymers...
March 1, 2017: IUCrJ
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