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https://www.readbyqxmd.com/read/28927667/development-and-validation-of-a-tool-to-evaluate-the-evolution-of-clinical-reasoning-in-trauma-using-virtual-patients
#1
David Fleiszer, Michael L Hoover, Nancy Posel, Tarek Razek, Simon Bergman
CONTEXT: Undergraduate medical students at a large academic trauma center are required to manage a series of online virtual trauma patients as a mandatory exercise during their surgical rotation. PURPOSE: Clinical reasoning during undergraduate medical education can be difficult to assess. The purpose of the study was to determine whether we could use components of the students' virtual patient management to measure changes in their clinical reasoning over the course of the clerkship year...
September 16, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28920078/notch1-activation-depletes-the-pool-of-side-population-stem-cells-in-atl
#2
Xue Tao Bai, Chien-Hung Yeh, Christophe Nicot
BACKGROUND: HTLV-I infection is associated with the development of adult T-cell leukemia (ATL), a malignancy characterized by a high rate of disease relapse and poor survival. Previous studies reported the existence of side population (SP) cells in HTLV-I Tax transgenic mouse models. These studies showed that these ATL-like derived SP cells have both self-renewal and leukemia renewal capacity and represent Cancer Stem Cells (CSC)/Leukemia-Initiating Cells (LIC). Since CSC/LIC are resistant to conventional therapies, a better characterization is needed...
June 2017: Journal of Cancer Sciences
https://www.readbyqxmd.com/read/28916919/laparoscopic-liver-resection-for-metastatic-melanoma
#3
Davit L Aghayan, Airazat M Kazaryan, Åsmund Avdem Fretland, Mushegh A Sahakyan, Bård I Røsok, Bjørn Atle Bjørnbeth, Bjørn Edwin
BACKGROUND: Stage IV metastatic melanoma carries a poor prognosis. In the case of melanoma liver metastasis (MLM), surgical resection may improve survival and represents a therapeutic option, with varying levels of success. Laparoscopic liver resection (LLR) for metastatic melanoma is poorly studied. The aim of this study was to analyze the outcomes of LLR in patients with MLM. MATERIALS AND METHODS: Between April 2000 and August 2013, 11 (1 cutaneous, 9 ocular and 1 unknown primary) patients underwent LLR for MLM at Oslo University Hospital-Rikshospitalet and 13 procedures in total were carried out...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28910576/impact-of-staphylococcus-aureus-regulatory-mutations-that-modulate-biofilm-formation-in-the-usa300-strain-lac-on-virulence-in-a-murine-bacteremia-model
#4
Joseph S Rom, Danielle N Atwood, Karen E Beenken, Daniel G Meeker, Allister J Loughran, Horace J Spencer, Tamara L Lantz, Mark S Smeltzer
Staphylococcus aureus causes acute and chronic forms of infection, the latter often associated with formation of a biofilm. It has previously been demonstrated that mutation of atl, codY, rot, sarA, and sigB limits biofilm formation in the USA300 strain LAC while mutation of agr, fur, and mgrA has the opposite effect. Here we used a murine sepsis model to assess the impact of these same loci in acute infection. Mutation of agr, atl, and fur had no impact on virulence, while mutation of mgrA and rot increased virulence...
September 14, 2017: Virulence
https://www.readbyqxmd.com/read/28910419/il-10-mediated-signals-act-as-a-switch-for-lymphoproliferation-in-human-t-cell-leukemia-virus-type-1-infection-by-activating-the-stat3-and-irf4-pathways
#5
Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi
Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since there are no disease-specific differences among HTLV-1 strains, the etiological mechanisms separating these respective lymphoproliferative and inflammatory diseases are not well understood. In this study, by using IL-2-dependent HTLV-1-infected T-cell lines (ILTs) established from patients with ATL and HAM/TSP, we demonstrate that the anti-inflammatory cytokine IL-10 and its downstream signals potentially act as a switch for proliferation in HTLV-1-infected cells...
September 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28905463/epidemiological-and-clinical-features-of-adult-t-cell-leukemia-lymphoma-atl-in-japan-2010-2011-a-nationwide-survey
#6
Kisato Nosaka, Masako Iwanaga, Yoshitaka Imaizumi, Kenji Ishitsuka, Kenichi Ishizawa, Yoji Ishida, Masahiro Amano, Takashi Ishida, Naokuni Uike, Atae Utsunomiya, Koichi Ohshima, Kazuhiro Kawai, Junji Tanaka, Yoshiki Tokura, Kensei Tobinai, Toshiki Watanabe, Kaoru Uchimaru, Kunihiro Tsukasaki
Adult T-cell leukemia-lymphoma (ATL) is a mature T-cell malignancy associated with human T-cell leukemia virus type I (HTLV-1) infection. Japan is the most endemic country for HTLV-1 and ATL in the world. Recent nationwide studies of Japanese blood donors reported that HTLV-1 carriers spread from endemic areas to non-endemic areas. Therefore, the latest information on nationwide epidemiological and clinical data for ATL is necessary to guide clinical practice. We conducted a multicenter, hospital-based survey of newly diagnosed ATL patients from 2010 to 2011...
September 14, 2017: Cancer Science
https://www.readbyqxmd.com/read/28902872/anodal-transcranial-direct-current-stimulation-of-the-right-anterior-temporal-lobe-did-not-significantly-affect-verbal-insight
#7
Takatsugu Aihara, Takeshi Ogawa, Takeaki Shimokawa, Okito Yamashita
Humans often utilize past experience to solve difficult problems. However, if past experience is insufficient to solve a problem, solvers may reach an impasse. Insight can be valuable for breaking an impasse, enabling the reinterpretation or re-representation of a problem. Previous studies using between-subjects designs have revealed a causal relationship between the anterior temporal lobes (ATLs) and non-verbal insight, by enhancing the right ATL while inhibiting the left ATL using transcranial direct current stimulation (tDCS)...
2017: PloS One
https://www.readbyqxmd.com/read/28899435/optimizing-visits-to-the-site-of-death-for-bereaved-families-after-disasters-and-terrorist-events
#8
Pål Kristensen, Atle Dyregrov, Lars Weisæth, Marianne Straume, Kari Dyregrov, Trond Heir, Renate Grønvold Bugge
In recent years it has been common after disasters and terrorist events to offer bereaved families the opportunity to visit the place where their loved ones died. Many report that such visits are beneficial in processing their loss. Various factors, both cognitive (eg, counteracting disbelief) and existential or emotional (eg, achieving a sense of closeness to the deceased), are associated with the experienced benefit. Nonetheless, exacerbations of trauma and grief reactions (eg, re-enactment fantasies) are common, with some of the bereaved also reporting adverse reactions after the visit...
September 13, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28893939/human-t-cell-leukaemia-virus-type-1-parasitism-and-pathogenesis
#9
REVIEW
Charles R M Bangham, Masao Matsuoka
Human T-cell leukaemia virus type 1 (HTLV-1) causes not only adult T-cell leukaemia-lymphoma (ATL), but also inflammatory diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 transmits primarily through cell-to-cell contact, and generates abundant infected cells in the host in order to survive and transmit to a new host. The resulting high proviral load is closely associated with the development of ATL and inflammatory diseases. To increase the number of infected cells, HTLV-1 changes the immunophenotype of infected cells, induces proliferation and inhibits apoptosis through the cooperative actions of two viral genes, tax and HTLV-1 bZIP factor (HBZ)...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28892503/structural-and-functional-correlates-for-language-efficiency-in-auditory-word-processing
#10
JeYoung Jung, Sunmi Kim, Hyesuk Cho, Kichun Nam
This study aims to provide convergent understanding of the neural basis of auditory word processing efficiency using a multimodal imaging. We investigated the structural and functional correlates of word processing efficiency in healthy individuals. We acquired two structural imaging (T1-weighted imaging and diffusion tensor imaging) and functional magnetic resonance imaging (fMRI) during auditory word processing (phonological and semantic tasks). Our results showed that better phonological performance was predicted by the greater thalamus activity...
2017: PloS One
https://www.readbyqxmd.com/read/28891363/exploring-the-association-of-dental-care-utilization-with-oral-impacts-on-daily-performances-oidp-a-prospective-study-of-ageing-people-in-norway-and-sweden
#11
Ferda Gülcan, Gunnar Ekbäck, Sven Ordell, Kristin S Klock, Stein Atle Lie, Anne Nordrehaug Åstrøm
OBJECTIVES: To explore the association of dental health care utilization with oral impacts on daily performances (OIDP) across time focusing ageing Norwegian and Swedish adults adjusting for predisposing, enabling, and need related-factors as defined by Andersen's model. METHODS: Data were based on Norwegian and Swedish 1942 birth-cohorts conducted in 2007 (age 65) and 2012 (age 70). In Norway, the response rates ranged from 54% to 58%. Corresponding figures in Sweden were from 72% to 73%...
September 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28889364/open-complete-anterior-dislocation-of-the-sacro-iliac-joint-in-a-4-year-old-boy-a-case-report-of-a-rare-injury-with-5-year-follow-up
#12
Walid A Elnahal, Mahmoud Fahmy, Mehool Acharya
Pelvic fractures are uncommon in children and account for between 0.3 and 7.5% of all pediatric injuries. Open pelvic fractures only account for up to 12.9% of all pediatric pelvic fractures. An unusual case of open complete anterior sacro-iliac joint dislocation in a 4-year-old boy is presented with a long-term follow-up. The multidisciplinary approach is reported with review of the current literature. A 4-year-old male presented to our institution in January 2012 after having been run over by a tractor. He presented with gross hemodynamical instability, MISS of 25, and an unstable lateral compression type III pelvic fracture with complete anterior dislocation of the left hemipelvis and a groin wound extending into the left thigh...
September 9, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28888743/htlv-1-infected-thymic-epithelial-cells-convey-the-virus-to-cd4-t-lymphocytes
#13
Luciana Rodrigues Carvalho Barros, Leandra Linhares-Lacerda, Klaysa Moreira-Ramos, Marcelo Ribeiro-Alves, Maria Cristina Machado Motta, Dumith Chequer Bou-Habib, Wilson Savino
The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4(+)T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells...
August 14, 2017: Immunobiology
https://www.readbyqxmd.com/read/28885891/signal-enhancement-of-the-dentate-nucleus-at-unenhanced-mr-imaging-after-very-high-cumulative-doses-of-the-macrocyclic-gadolinium-based-contrast-agent-gadobutrol-an-observational-study
#14
Atle Bjørnerud, Svein Are Sirirud Vatnehol, Christopher Larsson, Paulina Due-Tønnessen, Per Kristian Hol, Inge Rasmus Groote
Purpose To test for measurable visual enhancement of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images in a cohort of patients with a primary brain tumor who had not received linear gadolinium-based contrast agents (GBCAs) but had received many injections of macrocyclic GBCAs. Materials and Methods Seventeen patients with high-grade gliomas who had received 10-44 administrations of the macrocyclic GBCA gadobutrol (0.1 mmol/kg of body weight) were retrospectively included in this regional ethics committee-approved study...
September 8, 2017: Radiology
https://www.readbyqxmd.com/read/28881635/htlv-1-tax-upregulates-early-growth-response-protein-1-through-nuclear-factor-%C3%AE%C2%BAb-signaling
#15
Qingsong Huang, Zhiguo Niu, Jingxian Han, Xihong Liu, Zhuangwei Lv, Huanhuan Li, Lixiang Yuan, Xiangping Li, Shuming Sun, Hui Wang, Xinxiang Huang
Human T cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that causes adult T cell leukemia (ATL) in susceptible individuals. The HTLV-1-encoded oncoprotein Tax induces persistent activation of the nuclear factor-κB (NF-κB) pathway. Early growth response protein 1 (EGR1) is overexpressed in HTLV-1-infected T cell lines and ATL cells. Here, we showed that both Tax expression and HTLV-1 infection promoted EGR1 overexpression. Loss of the NF-κB binding site in the EGR1 promotor or inhibition of NF-κB activation reduced Tax-induced EGR1 upregulation...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879200/the-nuclear-proteome-of-white-and-gray-matter-from-schizophrenia-postmortem-brains
#16
Verônica M Saia-Cereda, Aline G Santana, Andrea Schmitt, Peter Falkai, Daniel Martins-de-Souza
Schizophrenia (SCZ) is a serious neuropsychiatric disorder that manifests through several symptoms from early adulthood. Numerous studies over the last decades have led to significant advances in increasing our understanding of the factors involved in SCZ. For example, mass spectrometry-based proteomic analysis has provided important insights by uncovering protein dysfunctions inherent to SCZ. Here, we present a comprehensive analysis of the nuclear proteome of postmortem brain tissues from corpus callosum (CC) and anterior temporal lobe (ATL)...
July 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/28879086/emotion-detection-deficits-and-changes-in-personality-traits-linked-to-loss-of-white-matter-integrity-in-primary-progressive-aphasia
#17
Namita Multani, Sebastiano Galantucci, Stephen M Wilson, Tal Shany-Ur, Pardis Poorzand, Matthew E Growdon, Jung Yun Jang, Joel H Kramer, Bruce L Miller, Katherine P Rankin, Maria Luisa Gorno-Tempini, Maria Carmela Tartaglia
Non-cognitive features including personality changes are increasingly recognized in the three PPA variants (semantic-svPPA, non fluent-nfvPPA, and logopenic-lvPPA). However, differences in emotion processing among the PPA variants and its association with white matter tracts are unknown. We compared emotion detection across the three PPA variants and healthy controls (HC), and related them to white matter tract integrity and cortical degeneration. Personality traits in the PPA group were also examined in relation to white matter tracts...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28870995/one-hundred-years-on-ypres-and-atls
#18
Rachael Sv Parker, Paul J Parker
No abstract text is available yet for this article.
September 4, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28867574/decline-in-word-finding-the-objective-cognitive-finding-most-relevant-to-patients-after-mesial-temporal-lobe-epilepsy-surgery
#19
Carla Pauli, Maria Emilia Rodrigues de Oliveira Thais, Ricardo Guarnieri, Marcelo Liborio Schwarzbold, Alexandre Paim Diaz, Juliana Ben, Marcelo Neves Linhares, Hans Joachim Markowitsch, Peter Wolf, Samuel Wiebe, Katia Lin, Roger Walz
PURPOSE: The purpose of this study was to investigate the following: i) the objective impairment in neuropsychological tests that were associated with the subjective perception of cognitive function decline in Brazilian patients who underwent mesial temporal lobe epilepsy (MTLE) surgery and ii) the predictive variables for those impaired objective neuropsychological tests. METHODS: Forty-eight adults with MTLE (27 right HS and 23 male) were divided according to their perception of changes (Decline or No-decline) of cognitive function domain of the QOLIE-31 questionnaire applied before and 1year after the ATL...
August 31, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28866351/human-t-cell-leukemia-virus-type-i-tax-genotype-analysis-in-okinawa-the-southernmost-and-remotest-islands-of-japan-different-distributions-compared-with-mainland-japan-and-the-potential-value-for-the-prognosis-of-aggressive-adult-t-cell-leukemia-lymphoma
#20
Shugo Sakihama, Mineki Saito, Megumi Kuba-Miyara, Takeaki Tomoyose, Naoya Taira, Takashi Miyagi, Masaki Hayashi, Shigeko Kinjo, Sawako Nakachi, Iori Tedokon, Yukiko Nishi, Keita Tamaki, Kazuho Morichika, Jun-Nosuke Uchihara, Satoko Morishima, Ken-Nosuke Karube, Yuetsu Tanaka, Hiroaki Masuzaki, Takuya Fukushima
Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB cases-differed from that of a previous report from Kagoshima Prefecture in mainland Japan (taxA, 10%; taxB, 90%)...
August 18, 2017: Leukemia Research
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