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Penile curvature

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https://www.readbyqxmd.com/read/28791261/rationale-of-combination-therapy-with-antioxidants-in-medical-management-of-peyronie-s-disease-results-of-clinical-application
#1
Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta, Andrea Fabiani
Peyronie's disease (PD) is a connective tissue disorder involving the tunica albuginea of the corpora cavernosa of the penis. We have published several studies describing a "combined therapy" for PD patients, but the present study aims to clearly demonstrate how the association between various antioxidants in PD treatment can significantly increase the likelihood of therapeutic success. We used the following substances: silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28789936/buck-s-fascia-repair-with-glanuloplasty-in-hypospadias-surgery-a-simple-approach-with-excellent-outcome
#2
Aejaz Ahsan Baba, Sajad Ahmad Wani, Nisar Ahmad Bhat, Gowhar Nazir Mufti, Tariq Nazir Lone, Shaista Nazir
BACKGROUND: Hypospadias is a common problem encountered in surgical practice and its repair is challenging because of various complications. Urethro-cutaneous fistula is the most common postoperative complication (incidence of 0-33%). Different types of intermediate protective layers have been used in attempts to decrease UCF formation; however, no single surgical technique is ideal. OBJECTIVE: The aim of this study was to compare use of dartos fascia and Buck's fascia as intermediate layers in prevention of the formation of UCF...
July 16, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28727375/an-unanswered-question-in-pediatric-urology-the-post-pubertal-persistence-of-prepubertal-congenital-penile-curvature-correction-by-tunical-plication
#3
Ünsal Ozkuvanci, Orhan Ziylan, M Irfan Dönmez, Omer Baris Yucel, Tayfun Oktar, Haluk Ander, Ismet Nane
OBJECTIVE: The aim of this study is to analyze post pubertal results of pre pubertal tunica albuginea plication with non-absorbable sutures in the correction of CPC. MATERIALS AND METHODS: The files of patients who underwent tunica albuginea plication without incision (dorsal/lateral) were retrospectively reviewed. Patients younger than 13 years of age at the time of operation and older than 14 years of age in November 2015 were included. Patients with a penile curvature of less than 30 degrees & more than 45 degrees and penile/urethral anomalies were excluded...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28718527/evaluation-of-intralesional-injection-of-hyaluronic-acid-compared-with-verapamil-in-peyronie-s-disease-preliminary-results-from-a-prospective-double-blinded-randomized-study
#4
V Favilla, G I Russo, A Zucchi, G Siracusa, S Privitera, S Cimino, M Madonia, T Cai, G Cavallini, G Liguori, G D'Achille, M Silvani, G Franco, P Verze, A Palmieri, B Torrisi, V Mirone, G Morgia
Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). This is a multi-centre prospective double-arm, randomized, double-blinded study comparing ILVI vs. intralesional HA after 12-weeks. Sexually active men, older than 18 years and affected by the acute phase of PD were eligible for this study...
July 2017: Andrology
https://www.readbyqxmd.com/read/28712888/is-concealed-epispadias-a-rare-variant
#5
Ahmed Shahat, Ahmed S Safwat, Ahmad Elderwy, Islam F Abdelkawi, Ahmad Elbadry I Abonnoor, Mohamed F Abdelhafez, Ahmed Moeen, Hisham Hammouda
OBJECTIVE: To present our experience with concealed epispadias and to estimate its actual share in the isolated male epispadias cases and its effect on the surgical outcome. MATERIALS AND METHODS: Consecutive patients with isolated male epispadias treated in our center between 2008 and 2015 were classified into concealed and classic epispadias. The two groups were compared regarding age at presentation, meatal location, incontinence, dorsal curvature, success rate and complications...
July 13, 2017: Urology
https://www.readbyqxmd.com/read/28711404/penile-plication-with-or-without-degloving-of-the-penis-results-in-similar-outcomes
#6
Rustam Kadirov, Burhan Coskun, Onur Kaygisiz, Kadir Omur Gunseren, Yakup Kordan, Ismet Yavascaoglu, Hakan Kilicarslan
BACKGROUND: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature. AIM: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis. METHODS: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. OUTCOMES: Surgical success rates, complications, and patient satisfaction determined with the Treatment Benefit Scale were compared between groups...
July 13, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28676223/prevalence-of-peyronie-s-disease-like-symptoms-in-men-presenting-with-dupuytren-contractures
#7
Alan W Shindel, Genevieve Sweet, William Thieu, Blythe Durbin-Johnson, Jennifer Rothschild, Robert Szabo
INTRODUCTION: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism. AIM: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC. METHODS: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. The survey assessed several basic demographic and sexual health factors and included items from the International Index of Erectile Function and the Erection Hardness Scale...
July 1, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28630018/the-modified-ulaanbaatar-procedure-reduced-complications-and-enhanced-cosmetic-outcome-for-the-most-severe-cases-of-hypospadias
#8
V R Jayanthi, C B Ching, D G DaJusta, D J McLeod, S A Alpert
INTRODUCTION/OBJECTIVE: Proximal hypospadias is one of the most challenging conditions that pediatric urologists have to deal with. Many procedures have been devised over the years, but nothing has been proven to be the best option. Although there have been some attempts at correcting severe hypospadias in one procedure, most have advocated a staged approach. The classic approach - laying penile skin or a graft within a split glans followed by glanuloplasty at the second stage - by definition requires two operations on the glans...
May 18, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28612401/safety-and-effectiveness-of-collagenase-clostridium-histolyticum-cch-xiapex-%C3%A2-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#9
Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver George Ralph, Giulio Garaffa, Andrew Nim Christopher, David John Ralph
OBJECTIVES: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. PATIENTS AND METHODS: A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol...
June 14, 2017: BJU International
https://www.readbyqxmd.com/read/28596205/congenital-prepubic-sinus-an-epispadiac-variant-of-dorsal-urethral-duplication-with-dorsal-penile-curvature-in-an-adult-man-a-rare-association
#10
Ruchir Aeron, Sunny Goel, Manmeet Singh, Ashok Kumar Gupta
Urethral duplication is among a very rare congenital disorder with multiple anatomical variants reported. Urethral duplication of complete type is usually diagnosed during childhood with urinary incontinence or double urinary stream as common presentation. However, patients with incomplete urethral duplication usually present with intermittent mucous discharge from the accessory urethral opening. A 20-year-old man presented to us with intermittent mucous discharge from the accessory opening along with dorsal penile curvature making sexual intercourse very difficult...
June 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28554517/factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-s-disease
#11
Ege C Serefoglu, Ted M Smith, Gregory J Kaufman, Genzhou Liu, Faysal A Yafi, Wayne J G Hellstrom
OBJECTIVE: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie's disease (PD). METHODS: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in two phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies [IMPRESS-I; n = 417] and IMPRESS-II [n = 415])...
May 26, 2017: Urology
https://www.readbyqxmd.com/read/28537694/a-new-technique-combined-plication-incision-cpi-for-correction-of-penile-curvature
#12
Hamed Abdalla Hamed, Mohamed Roaiah, Ahmed M Hassanin, Adham Ashraf Zaazaa, Mahmoud Fawzi
INTRODUCTION: Penile curvature (PC) can be surgically corrected by either corporoplasty or plication techniques. These techniques can be complicated by post-operative: penile shortening, recurrent PC, painful/palpable suture knots and erectile dysfunction. OBJECTIVE: To avoid the complications of corporoplasty and plication techniques using a new technique: combined plication-incision (CPI). MATERIALS AND METHODS: Two groups (1&2) were operated upon: group 1 using CPI and group 2 using the 16-dot technique...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-disease
#13
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included...
August 2017: Urology
https://www.readbyqxmd.com/read/28490036/fractured-penis-not-so-rare
#14
Ashwin S Tamhankar, Prakash W Pawar, Ajit S Sawant, Gaurav V Kasat, Abhishek Savaliya, Shankar Mundhe, Sunil Patil, Sayalee Narwade
INTRODUCTION: Penile fracture is a relatively common phenomenon. The main problem associated with this condition is the lack of patients' awareness on the urgency of the situation. This study reports the different modes of presentations and treatment results. MATERIALS AND METHODS: We reviewed 21 cases of penile fracture over 5 years. Parameters were mode of injury, age group, time interval before presentation, management, site of injury, urethral involvement, results, complications and erectile function at follow-up...
2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28482350/does-transfer-capacitive-resistive-energy-has-a-therapeutic-effect-on-peyronie-s-disease-randomized-single-blind-sham-controlled-study-on-96-patients-fast-pain-relief
#15
Carlo Pavone, Salvatore Romeo, Francesco D'Amato, Manuela Usala, Giulia Letizia Mauro, Giovanni Caruana
Background/Aims/Objectives: We have investigated the clinical and physiological effects of Transfer Capacitive Resistive Energy (TCARE) therapy on men with Peyronie's disease (PD). METHODS: Ninety-six men with PD have been randomized in a 2:1 ratio to receive 3 sessions of TCARE therapy or sham therapy. Pain, penile curvature and erectile function have been assessed before the first treatment and up to 9 months after the end of treatment, using the Visual Analogue Scale for the pain, a goniometer to measure the degree of curvature using at-home photography and an International Index of Erectile Function (IIEF-5) questionnaire...
2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28460995/three-dimensional-photography-for-quantitative-assessment-of-penile-volume-loss-deformities-in-peyronie-s-disease
#16
Ezra J Margolin, Carrie M Mlynarczyk, John P Mulhall, Doron S Stember, Peter J Stahl
BACKGROUND: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care. AIM: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28454897/collagenase-clostridium-histolyticum-in-the-treatment-of-urologic-disease-current-and-future-impact
#17
REVIEW
Andrew T Gabrielson, Jonathan T Spitz, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease...
April 25, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28443146/can-it-wait-a-systematic-review-of-immediate-vs-delayed-surgical-repair-of-penile-fractures
#18
Nathan Colin Wong, Shawn Dason, Rahul K Bansal, Timothy O Davies, Luis H Braga
INTRODUCTION: Penile fractures have classically been thought to require immediate surgical intervention; however, recent series have described acceptable outcomes with delayed repair. In this systematic review, we compared complication rates between immediate and delayed repair of penile fractures. METHODS: A systematic search of MEDLINE, Embase, CENTRAL, and Web of Science was performed with predefined search terms between 1974 and 2015. Titles and abstracts were screened prior to full-text review and quality appraisal by two independent investigators...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28395998/changes-in-the-effects-of-peyronie-s-disease-after-treatment-with-collagenase-clostridium-histolyticum-male-patients-and-their-female-partners
#19
Irwin Goldstein, L Dean Knoll, Larry I Lipshultz, Ted Smith, Gregory J Kaufman, Chris G McMahon
INTRODUCTION: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men. AIM: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners...
June 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28347795/clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#20
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Ross A Avant, Joshua B Savage, Landon W Trost
OBJECTIVE: To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD). MATERIALS AND METHODS: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. A final curve assessment was performed after patients completed CCH. A prospective database was maintained, including patient-reported frequency and duration of PTT...
March 24, 2017: Urology
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