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https://www.readbyqxmd.com/read/28280315/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-patient-selection-and-perspectives
#1
REVIEW
Paige K Kuhlmann, Kenneth J DeLay, James Anaissie, Wayne Jg Hellstrom, Faysal A Yafi
The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28258954/prevalence-and-predicting-factors-for-commonly-neglected-sexual-side-effects-to-external-beam-radiation-therapy-for-prostate-cancer
#2
Anders Frey, Christian Pedersen, Henriette Lindberg, Rasmus Bisbjerg, Jens Sønksen, Mikkel Fode
INTRODUCTION: Changes in sexual function other than erectile dysfunction are sparsely investigated after radiation therapy for prostate cancer. AIM: To investigate orgasmic dysfunction, urinary incontinence during sexual activity, changes in penile morphology, and sensory disturbances in the penis in patients with prostate cancer treated with external-beam radiation therapy (EBRT). METHODS: In February 2015, men treated with EBRT at our center 3 months to 5 years previously (N = 519) received a study-specific questionnaire...
February 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258933/contemporary-review-of-grafting-techniques-for-the-surgical-treatment-of-peyronie-s-disease
#3
REVIEW
Georgios Hatzichristodoulou, Daniar Osmonov, Hubert Kübler, Wayne J G Hellstrom, Faysal A Yafi
INTRODUCTION: Peyronie's disease (PD) is a benign fibrotic disorder of the tunica albuginea of the penis, which can cause penile pain, curvature, shortening, erectile dysfunction, and psychological distress. Surgery is indicated when penile curvature prevents satisfactory sexual intercourse. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. AIM: To provide an overview of recent studies reporting outcomes of grafting techniques and to report advances in the development of new grafting materials for PD surgery...
February 28, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28213855/correction-of-residual-ventral-penile-curvature-after-division-of-the-urethral-plate-in-the-first-stage-of-a-2-stage-proximal-hypospadias-repair
#4
REVIEW
Bruce J Schlomer
PURPOSE OF REVIEW: The first stage of a 2-stage proximal hypospadias repair involves division of the urethral plate and correction of any residual ventral penile curvature (VPC). Options to correct residual VPC include dorsal corporal shortening or ventral corporal lengthening techniques. This review discusses these options and suggests an approach to management. RECENT FINDINGS: Recent reports of 2-stage proximal hypospadias repairs indicate low rates of recurrent VPC with either dorsal corporal shortening or ventral corporal lengthening...
February 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28187522/survey-of-patient-and-partner-satisfaction-following-collagenase-clostridium-histolyticum-treatment-for-peyronie-s-disease
#5
J Anaissie, F A Yafi, E J Traore, S C Sikka, W J G Hellstrom
Intralesional injection of collagenase Clostridium histolyticum (CCH) is a minimally invasive, Food and Drug Administration-approved, effective treatment for Peyronie's disease (PD). To assess the satisfaction of patients and their female sexual partners (FSP) following CCH therapy for PD, we conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
March 2017: Andrology
https://www.readbyqxmd.com/read/28125311/functional-outcomes-following-immediate-repair-of-penile-fracture-a-tertiary-referral-centre-experience-with-76-consecutive-patients
#6
Francesco De Luca, Giulio Garaffa, Marco Falcone, Amr Raheem, Evangelos Zacharakis, Majed Shabbir, Abdelkareem Aljubran, Asif Muneer, Fiona Holden, Claire Akers, Nim Christopher, David J Ralph
OBJECTIVE: The aim of this study was to report surgical and functional outcomes in patients who underwent immediate penile fracture repair following location of the tunical tear with ultrasonography. METHODS: Patients' clinical notes from September 2005 to October 2015 were reviewed. The inclusion criteria were the documented presence of an albugineal laceration at the preoperative ultrasonography and during surgical exploration. In total, 76 patients were enrolled in the study...
January 26, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28077881/a-pilot-study-of-penile-hemodynamics-in-men-with-penile-curvatures
#7
A A Zaazaa, I Fathy, O Ayman, A Hassanin, H Ghanem
Penile curvature (PC) is bothersome to the patient. PC is either congenital or acquired. In most of the circulatory system, blood flows in a laminar profile with minimal energy expenditure. When a fluid passes in a curved tube, the laminar profile is disturbed and changed into a turbulent flow. It increases the energy expenditure and reduces the flow. Turbulent flow may have a role in the development of an atherosclerotic plaque and in localizing its site. The aim of this research was to study penile hemodynamics before and after correction of PC...
March 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28057983/role-of-extracorporeal-shock-wave-therapy-in-management-of-peyronie-s-disease-a-preliminary-report
#8
Rajendra Kashinath Shimpi, Ravi Jineshkumar Jain
INTRODUCTION: Peyronie's Disease (PD) is a disease causing psycho social trauma to the patient. Multiple treatment options are available with variable results. Extra Corporeal Shock Wave Therapy (ESWT) is a new insight into the non invasive modality of management. It focuses on the mechanism of inducing angiogenesis in the penile cavernous tissue. MATERIALS AND METHODS: The aim of the study is to determine the role of ESWT in the management of PD. The objectives include demonstrating the improvement in mean International Index of Erectile Function Score (IIEFS), improvement in pain score by Visual Analogue Scale (VAS), change in cavernosal artery flow on colour penile Doppler, reduction in plaque size, and improvement in penile curvature degree after the therapy...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/27979563/re-do-adult-men-with-untreated-ventral-penile-curvature-have-adverse-outcomes
#9
Douglas A Canning
No abstract text is available yet for this article.
January 2017: Journal of Urology
https://www.readbyqxmd.com/read/27909612/nonsurgical-treatment-options-in-peyronie-s-disease-2016-update
#10
REVIEW
Raidh A Talib, Mohammed Abdulkareem Ibrahim, Önder Cangüven
Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. In the last 5 years, commonly used oral medications left their places to intralesional therapies. Clostridium collagenase, which is the only Food and Drug Administration (FDA) approved treatment for PD, is now the most prescribed intralesional therapy in the last years...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27889116/total-phallic-reconstruction-using-radial-forearm-free-flap-after-iatrogenic-penile-amputation
#11
J C Angulo, I Arance, C Gómez-Llorens, C Esquinas, C Gómez-Martín, J L Fernández-Cañamaque
INTRODUCTION: The iatrogenic loss of the penis is a rare situation. We present a challenging case of deferred total penile reconstruction in a genetic male. MATERIAL AND METHODS: A 57-year-old man with the loss of the penis due to a penile abscess and necrosis secondary to penile curvature surgery. The reconstruction was performed over several operations using a radial forearm free flap (RFFF) and placement of a customised inflatable prosthesis a year later. RESULTS: During the first operation, the penile abscess was drained, the necrotic residues were debrided and placement of hypogastric drainage...
November 23, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27872029/association-between-infertility-and-sexual-dysfunction-in-men-and-women
#12
REVIEW
Michael H Berger, Marisa Messore, Alexander W Pastuszak, Ranjith Ramasamy
INTRODUCTION: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women. AIM: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27867021/patient-reported-long-term-sexual-outcomes-following-plication-surgery-for-penile-curvature-a-retrospective-58-patient-study
#13
A Baldini, N Morel-Journel, P Paparel, A Ruffion, J-E Terrier
OBJECTIVE: To evaluate long-term sexual function results following plication surgery for the correction of penile curvature using patient questionnaires. METHODS: We performed a single-center, retrospective study in a cohort of patients with Peyronie's disease or congenital penile curvature. All patients who underwent plication surgery on the convex aspect using the Nesbit, Yachia or diamond-shaped techniques were included. At a mean 34 months after the interventions, the patients were asked to respond to the IIEF5 questionnaire and a 19-item questionnaire...
November 18, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27864619/bicentric-prospective-evaluation-of-corporoplasty-with-porcine-small-intestinal-submucosa-sis-in-patients-with-severe-peyronie-s-disease
#14
K Sayedahmed, B Rosenhammer, P J Spachmann, M Burger, M Aragona, B T Kaftan, R Olianas, H M Fritsche
INTRODUCTION: Advanced Peyronie's disease (PD) with severe penile deviation demands grafting procedures following plaque incision or partial plaque excision in order to avoid penile shortening and to improve quality of life of affected patients. Small intestinal submucosa (SIS) is an established xenograft. The objective of the present study was to validate external results in a bicentric prospective manner. METHODS: Patient selection criteria, surgical technique and standards for pre- and postoperative care were defined...
November 18, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27845136/re-the-efficacy-of-congenital-penile-curvature-repair-in-preadolescent-males-early-outcomes
#15
Douglas A Canning
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27825744/small-intestinal-submucosa-grafting-for-peyronie-disease-outcomes-and-patient-satisfaction
#16
Pedro Valente, Carolina Gomes, Nuno Tomada
OBJECTIVE: To evaluate surgical outcomes and complications and assess overall patient satisfaction after small intestinal submucosa (SIS) grafting for Peyronie disease. METHODS: Twenty-eight patients were treated with tunical incision and grafting with SIS. Mean age of the patients was 58 (range: 43-71) years. A preoperative protocol was applied to all patients. Patients were also evaluated at follow-up clinic visits. The International Index of Erectile Function, a modified Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire, postoperative self-reports, and clinical characteristics were used to measure outcomes...
November 4, 2016: Urology
https://www.readbyqxmd.com/read/27816605/impact-of-number-of-cycles-of-collagenase-clostridium-histolyticum-on-outcomes-in-patients-with-peyronie-s-disease
#17
James Anaissie, Faysal A Yafi, Kenneth J DeLay, Elizabeth J Traore, Suresh C Sikka, Wayne J G Hellstrom
OBJECTIVE: To analyze the impact of the number of cycles of collagenase Clostridium histolyticum (CCH) intralesional injection therapy on outcomes to further characterize CCH therapy. METHODS: We conducted a retrospective review of the records of all patients treated with CCH for Peyronie disease between April 2014 and March 2016. Collected variables included demographics, pre- and posttreatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
November 2, 2016: Urology
https://www.readbyqxmd.com/read/27794432/cause-and-effect-versus-confounding-is-there-a-true-association-between-caudal-blocks-and-tubularized-incised-plate-repair-complications
#18
Luis H Braga, Kizanee Jegatheeswaran, Melissa McGrath, Bethany Easterbrook, Mandy Rickard, Jorge DeMaria, Armando J Lorenzo
PURPOSE: We studied the impact of caudal block vs dorsal penile block on the rate of urethrocutaneous fistula and glans dehiscence in children who underwent hypospadias repair. MATERIALS AND METHODS: We retrospectively reviewed the records of 849 consecutive patients who underwent tubularized incised plate repair between 2004 and 2015. A total of 331 cases with incomplete medical records, other techniques and redo repair were excluded. The preference for caudal block was based on anesthesiologist discretion...
October 26, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27760977/-two-cases-of-penile-fracture-diagnosed-by-magnetic-resonance-imaging
#19
Sohei Kuribayashi, Tetsuya Takao, Gaku Yamamichi, Masataka Kawamura, Kosuke Nakano, Nozomu Kishimoto, Go Tanigawa, Koichi Tsutahara, Seiji Yamaguchi
We report two cases of penile fracture. Case 1 was in a 22-year-old male. He heard a cracking sound during urination and experienced acute penile pain and detumescence. He was admitted to our hospital on that day. Case 2 was in a 52-year-old male. He heard a cracking sound during sexual intercourse and experienced detumescence. He was admitted to our hospital on the next day. In both cases, magnetic resonance imaging (MRI) showed disruption of the tunica albuginea. We performed immediate surgical repair through localized incision...
September 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27746896/-recent-advances-in-managing-peyronie-s-disease
#20
REVIEW
Oliver Kayes, Rauf Khadr
Peyronie's disease remains an under-reported and debilitating problem which can result in significant physical and psychological symptoms for some men. The classic symptom complex includes penile curvature, penile plaque, and penile pain. Men can also present with erectile dysfunction, penile instability, and penile shortening, alongside feelings of low mood/libido, dysmorphobia, and low self-esteem. This review highlights the current key publications in the medical literature and provides updates on new clinical therapies whilst postulating about potential future treatments on the horizon...
2016: F1000Research
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