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https://www.readbyqxmd.com/read/28923308/effect-of-penile-traction-and-vacuum-erectile-device-for-peyronie-s-disease-in-an-animal-model
#1
Haocheng Lin, Chunhui Liu, Run Wang
BACKGROUND: Penile traction therapy with the use of a traction device (TD) or vacuum erectile device (VED) has been studied as local modalities for Peyronie's disease (PD). AIM: To identify changes of penile curvature, erectile function, and possible cellular and molecular mechanisms between the TD and VED in a rat model of PD. METHODS: Peyronie's plaque was induced in 30 adult male rats. Then, rats were randomly divided into control (PD without treatment), VED, and TD groups...
September 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28904897/peyronie-s-graft-surgery-tips-and-tricks-from-the-masters-in-andrologic-surgery
#2
Georgios Hatzichristodoulou, Peter Tsambarlis, Hubert Kübler, Laurence A Levine
BACKGROUND: Grafting techniques in the surgical management of Peyronie's disease (PD) are challenging, especially in inexperienced hands. In order to improve surgical outcomes the urologist should follow a standard surgical approach, preferably of an established and reliable grafting technique. The aim of this study is to provide tips and tricks for graft surgery for PD. METHODS: This report offers a step-by-step tutorial for grafting techniques in PD, especially for the Sealing technique and the partial plaque excision and grafting (PEG) procedure...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28892596/peyronie-s-disease-watch-out-for-the-bend
#3
Christopher Love, Darren J Katz, Eric Chung, Ohad Shoshany
BACKGROUND: Peyronie's disease is a relatively common condition in urological practice, but is still poorly identified and understood in the wider medical community and by most of the public. Identifying the condition and appropriate referral for expert opinion can significantly lessen the physical and psychological effect on patients. OBJECTIVE: The objective of this article is to provide general practitioners with a concise and updated review of Peyronie's disease, with the aim of helping them to provide appropriate advice to their patients...
September 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28886994/successful-treatment-of-residual-curvature-in-peyronie-s-disease-in-men-previously-treated-with-intralesional-collagenase-clostridium-histolyticum
#4
Kenneth DeLay, Linley Diao, Hoang M T Nguyen, Jonathan Zurawin, Russell Libby, Faysal Yafi, Wayne J G Hellstrom
OBJECTIVE: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease. METHODS: We performed a retrospective analysis of patients who had intralesional CCH treatment for (PD) and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement. RESULTS: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified...
September 5, 2017: Urology
https://www.readbyqxmd.com/read/28879693/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-review-of-a-minimally-invasive-treatment-option
#5
REVIEW
Andrew T Gabrielson, Laith M Alzweri, Wayne Jg Hellstrom
Peyronie's disease (PD) is an inflammatory disorder characterized by an abnormal collagen deposition in the tunica albuginea of the penis, leading to fibrous and non-compliant plaques that can impede normal erection. Although pharmacological treatments are available, only intralesional injection therapy and surgical reconstruction have demonstrated tangible clinical efficacy in the management of this condition. Intralesional injection of collagenase clostridium histolyticum (CCH) has come to the forefront of minimally invasive treatment of PD...
September 6, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28874331/safety-and-efficacy-of-collagenase-clostridium-histolyticum-in-the-treatment-of-acute-phase-peyronie-s-disease
#6
Hoang Minh Tue Nguyen, James Anaissie, Kenneth J DeLay, Faysal A Yafi, Suresh C Sikka, Wayne J G Hellstrom
BACKGROUND: Peyronie's disease (PD), defined as the abnormal formation of fibrous plaque(s) in the tunica albuginea of the penis, is a chronic condition that afflicts 3% to 13% of the US male population; there is no current research on the efficacy and safety of collagenase Clostridium histolyticum (CCH) in the treatment of acute phase PD. AIM: To examine the efficacy and safety of CCH in the treatment of acute-phase PD. METHODS: We retrospectively reviewed the records for all patients treated with CCH for PD from April 2014 through April 2017...
September 2, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28874327/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-a-review-of-the-literature-and-a-new-modified-protocol
#7
REVIEW
Amr Abdel Raheem, Mark Johnson, Tarek Abdel-Raheem, Marco Capece, David Ralph
INTRODUCTION: Peyronie's disease (PD) is a common condition that results in penile deformity, which makes sexual intercourse difficult or impossible, and causes psychological, emotional, and relationship difficulties for the man affected and his partner. Collagenase Clostridium histolyticum (CCH; Xiapex, Xiaflex) is the first licensed non-surgical treatment option for PD. The safety and efficacy have been demonstrated in two large phase III randomized controlled trials (IMPRESS I and IMPRESS II)...
September 2, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28791261/rationale-of-combination-therapy-with-antioxidants-in-medical-management-of-peyronie-s-disease-results-of-clinical-application
#8
Gianni Paulis, Andrea Paulis, Gennaro Romano, Davide Barletta, Andrea Fabiani
Peyronie's disease (PD) is a connective tissue disorder involving the tunica albuginea of the corpora cavernosa of the penis. We have published several studies describing a "combined therapy" for PD patients, but the present study aims to clearly demonstrate how the association between various antioxidants in PD treatment can significantly increase the likelihood of therapeutic success. We used the following substances: silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28789936/buck-s-fascia-repair-with-glanuloplasty-in-hypospadias-surgery-a-simple-approach-with-excellent-outcome
#9
Aejaz Ahsan Baba, Sajad Ahmad Wani, Nisar Ahmad Bhat, Gowhar Nazir Mufti, Tariq Nazir Lone, Shaista Nazir
BACKGROUND: Hypospadias is a common problem encountered in surgical practice and its repair is challenging because of various complications. Urethro-cutaneous fistula is the most common postoperative complication (incidence of 0-33%). Different types of intermediate protective layers have been used in attempts to decrease UCF formation; however, no single surgical technique is ideal. OBJECTIVE: The aim of this study was to compare use of dartos fascia and Buck's fascia as intermediate layers in prevention of the formation of UCF...
July 16, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28727375/an-unanswered-question-in-pediatric-urology-the-post-pubertal-persistence-of-prepubertal-congenital-penile-curvature-correction-by-tunical-plication
#10
Ünsal Ozkuvanci, Orhan Ziylan, M Irfan Dönmez, Omer Baris Yucel, Tayfun Oktar, Haluk Ander, Ismet Nane
OBJECTIVE: The aim of this study is to analyze post pubertal results of pre pubertal tunica albuginea plication with non-absorbable sutures in the correction of CPC. MATERIALS AND METHODS: The files of patients who underwent tunica albuginea plication without incision (dorsal/lateral) were retrospectively reviewed. Patients younger than 13 years of age at the time of operation and older than 14 years of age in November 2015 were included. Patients with a penile curvature of less than 30 degrees & more than 45 degrees and penile/urethral anomalies were excluded...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28718527/evaluation-of-intralesional-injection-of-hyaluronic-acid-compared-with-verapamil-in-peyronie-s-disease-preliminary-results-from-a-prospective-double-blinded-randomized-study
#11
V Favilla, G I Russo, A Zucchi, G Siracusa, S Privitera, S Cimino, M Madonia, T Cai, G Cavallini, G Liguori, G D'Achille, M Silvani, G Franco, P Verze, A Palmieri, B Torrisi, V Mirone, G Morgia
Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). This is a multi-centre prospective double-arm, randomized, double-blinded study comparing ILVI vs. intralesional HA after 12-weeks. Sexually active men, older than 18 years and affected by the acute phase of PD were eligible for this study...
July 2017: Andrology
https://www.readbyqxmd.com/read/28712888/is-concealed-epispadias-a-rare-variant
#12
Ahmed Shahat, Ahmed S Safwat, Ahmad Elderwy, Islam F Abdelkawi, Ahmad Elbadry I Abonnoor, Mohamed F Abdelhafez, Ahmed Moeen, Hisham Hammouda
OBJECTIVE: To present our experience with concealed epispadias and to estimate its actual share in the isolated male epispadias cases and its effect on the surgical outcome. MATERIALS AND METHODS: Consecutive patients with isolated male epispadias treated in our center between 2008 and 2015 were classified into concealed and classic epispadias. The two groups were compared regarding age at presentation, meatal location, incontinence, dorsal curvature, success rate and complications...
July 13, 2017: Urology
https://www.readbyqxmd.com/read/28711404/penile-plication-with-or-without-degloving-of-the-penis-results-in-similar-outcomes
#13
Rustam Kadirov, Burhan Coskun, Onur Kaygisiz, Kadir Omur Gunseren, Yakup Kordan, Ismet Yavascaoglu, Hakan Kilicarslan
BACKGROUND: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature. AIM: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis. METHODS: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. OUTCOMES: Surgical success rates, complications, and patient satisfaction determined with the Treatment Benefit Scale were compared between groups...
September 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28676223/prevalence-of-peyronie-s-disease-like-symptoms-in-men-presenting-with-dupuytren-contractures
#14
Alan W Shindel, Genevieve Sweet, William Thieu, Blythe Durbin-Johnson, Jennifer Rothschild, Robert Szabo
INTRODUCTION: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism. AIM: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC. METHODS: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. The survey assessed several basic demographic and sexual health factors and included items from the International Index of Erectile Function and the Erection Hardness Scale...
September 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28630018/the-modified-ulaanbaatar-procedure-reduced-complications-and-enhanced-cosmetic-outcome-for-the-most-severe-cases-of-hypospadias
#15
V R Jayanthi, C B Ching, D G DaJusta, D J McLeod, S A Alpert
INTRODUCTION/OBJECTIVE: Proximal hypospadias is one of the most challenging conditions that pediatric urologists have to deal with. Many procedures have been devised over the years, but nothing has been proven to be the best option. Although there have been some attempts at correcting severe hypospadias in one procedure, most have advocated a staged approach. The classic approach - laying penile skin or a graft within a split glans followed by glanuloplasty at the second stage - by definition requires two operations on the glans...
May 18, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28612401/safety-and-effectiveness-of-collagenase-clostridium-histolyticum-cch-xiapex-%C3%A2-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#16
Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver George Ralph, Giulio Garaffa, Andrew Nim Christopher, David John Ralph
OBJECTIVES: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. PATIENTS AND METHODS: A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol...
June 14, 2017: BJU International
https://www.readbyqxmd.com/read/28596205/congenital-prepubic-sinus-an-epispadiac-variant-of-dorsal-urethral-duplication-with-dorsal-penile-curvature-in-an-adult-man-a-rare-association
#17
Ruchir Aeron, Sunny Goel, Manmeet Singh, Ashok Kumar Gupta
Urethral duplication is among a very rare congenital disorder with multiple anatomical variants reported. Urethral duplication of complete type is usually diagnosed during childhood with urinary incontinence or double urinary stream as common presentation. However, patients with incomplete urethral duplication usually present with intermittent mucous discharge from the accessory urethral opening. A 20-year-old man presented to us with intermittent mucous discharge from the accessory opening along with dorsal penile curvature making sexual intercourse very difficult...
June 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28554517/factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-disease
#18
Ege C Serefoglu, Ted M Smith, Gregory J Kaufman, Genzhou Liu, Faysal A Yafi, Wayne J G Hellstrom
OBJECTIVE: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD). METHODS: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study I [n = 417] and Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study II [n = 415])...
May 26, 2017: Urology
https://www.readbyqxmd.com/read/28537694/a-new-technique-combined-plication-incision-cpi-for-correction-of-penile-curvature
#19
Hamed Abdalla Hamed, Mohamed Roaiah, Ahmed M Hassanin, Adham Ashraf Zaazaa, Mahmoud Fawzi
INTRODUCTION: Penile curvature (PC) can be surgically corrected by either corporoplasty or plication techniques. These techniques can be complicated by post-operative: penile shortening, recurrent PC, painful/palpable suture knots and erectile dysfunction. OBJECTIVE: To avoid the complications of corporoplasty and plication techniques using a new technique: combined plication-incision (CPI). MATERIALS AND METHODS: Two groups (1&2) were operated upon: group 1 using CPI and group 2 using the 16-dot technique...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-disease
#20
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included...
August 2017: Urology
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