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https://www.readbyqxmd.com/read/27909612/nonsurgical-treatment-options-in-peyronie-s-disease-2016-update
#1
REVIEW
Raidh A Talib, Mohammed Abdulkareem Ibrahim, Önder Cangüven
Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. In the last 5 years, commonly used oral medications left their places to intralesional therapies. Clostridium collagenase, which is the only Food and Drug Administration (FDA) approved treatment for PD, is now the most prescribed intralesional therapy in the last years...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27889116/total-phallic-reconstruction-using-radial-forearm-free-flap-after-iatrogenic-penile-amputation
#2
J C Angulo, I Arance, C Gómez-Llorens, C Esquinas, C Gómez-Martín, J L Fernández-Cañamaque
INTRODUCTION: The iatrogenic loss of the penis is a rare situation. We present a challenging case of deferred total penile reconstruction in a genetic male. MATERIAL AND METHODS: A 57-year-old man with the loss of the penis due to a penile abscess and necrosis secondary to penile curvature surgery. The reconstruction was performed over several operations using a radial forearm free flap (RFFF) and placement of a customised inflatable prosthesis a year later. RESULTS: During the first operation, the penile abscess was drained, the necrotic residues were debrided and placement of hypogastric drainage...
November 23, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27872029/association-between-infertility-and-sexual-dysfunction-in-men-and-women
#3
REVIEW
Michael H Berger, Marisa Messore, Alexander W Pastuszak, Ranjith Ramasamy
INTRODUCTION: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women. AIM: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27867021/patient-reported-long-term-sexual-outcomes-following-plication-surgery-for-penile-curvature-a-retrospective-58-patient-study
#4
A Baldini, N Morel-Journel, P Paparel, A Ruffion, J-E Terrier
OBJECTIVE: To evaluate long-term sexual function results following plication surgery for the correction of penile curvature using patient questionnaires. METHODS: We performed a single-center, retrospective study in a cohort of patients with Peyronie's disease or congenital penile curvature. All patients who underwent plication surgery on the convex aspect using the Nesbit, Yachia or diamond-shaped techniques were included. At a mean 34 months after the interventions, the patients were asked to respond to the IIEF5 questionnaire and a 19-item questionnaire...
November 17, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27864619/bicentric-prospective-evaluation-of-corporoplasty-with-porcine-small-intestinal-submucosa-sis-in-patients-with-severe-peyronie-s-disease
#5
K Sayedahmed, B Rosenhammer, P J Spachmann, M Burger, M Aragona, B T Kaftan, R Olianas, H M Fritsche
INTRODUCTION: Advanced Peyronie's disease (PD) with severe penile deviation demands grafting procedures following plaque incision or partial plaque excision in order to avoid penile shortening and to improve quality of life of affected patients. Small intestinal submucosa (SIS) is an established xenograft. The objective of the present study was to validate external results in a bicentric prospective manner. METHODS: Patient selection criteria, surgical technique and standards for pre- and postoperative care were defined...
November 18, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27845136/re-the-efficacy-of-congenital-penile-curvature-repair-in-preadolescent-males-early-outcomes
#6
Douglas A Canning
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27825744/small-intestinal-submucosa-grafting-for-peyronie-s-disease-outcomes-and-patient-satisfaction
#7
Pedro Valente, Carolina Gomes, Nuno Tomada
OBJECTIVES: To evaluate surgical outcomes and complications and assess overall patient satisfaction after small intestinal submucosa (SIS) grafting for PD. METHODS: Twenty-eight patients were treated with tunical incision and grafting with SIS. Mean age was 58 years (range:43-71). A preoperative protocol was applied to all patients. Patients were also evaluated at follow-up clinic visits. The International Index of Erectile Function (IIEF-5), a modified Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire, postoperative self-reports and clinical characteristics were used to measure outcomes...
November 4, 2016: Urology
https://www.readbyqxmd.com/read/27816605/impact-of-number-of-cycles-of-collagenase-clostridium-histolyticum-on-outcomes-in-patients-with-peyronie-s-disease
#8
James Anaissie, Faysal A Yafi, Kenneth J DeLay, Elizabeth J Traore, Suresh C Sikka, Wayne J G Hellstrom
OBJECTIVE: To analyze the impact of the number of cycles of collagenase Clostridium histolyticum (CCH) intralesional injection therapy on outcomes in order to further characterize CCH therapy. METHODS: We conducted a retrospective review of the records of all patients treated with CCH for PD between 04/2014 and 03/2016. Collected variables included demographics, pre- and post-treatment sexual function, penile curvature, penile vascular findings, and treatment outcomes...
November 2, 2016: Urology
https://www.readbyqxmd.com/read/27794432/cause-and-effect-versus-confounding-is-there-a-true-association-between-caudal-blocks-and-tubularized-incised-plate-repair-complications
#9
Luis H Braga, Kizanee Jegatheeswaran, Melissa McGrath, Bethany Easterbrook B Kin, Mandy Rickard, Jorge DeMaria, Armando J Lorenzo
INTRODUCTION: To study the impact of caudal block (CB) versus dorsal penile block (DPB) on the rate of urethrocutaneous fistula (UCF) and glans dehiscence (GD) in children who underwent hypospadias repair. METHODS: We conducted a retrospective review of consecutive patients who underwent tubularized incised plate repair between 2004-2015 (n=849). Incomplete medical records, other techniques and re-do cases were excluded(n=331). Preference for CB was based on anesthesiologist's discretion...
October 26, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27760977/-two-cases-of-penile-fracture-diagnosed-by-magnetic-resonance-imaging
#10
Sohei Kuribayashi, Tetsuya Takao, Gaku Yamamichi, Masataka Kawamura, Kosuke Nakano, Nozomu Kishimoto, Go Tanigawa, Koichi Tsutahara, Seiji Yamaguchi
We report two cases of penile fracture. Case 1 was in a 22-year-old male. He heard a cracking sound during urination and experienced acute penile pain and detumescence. He was admitted to our hospital on that day. Case 2 was in a 52-year-old male. He heard a cracking sound during sexual intercourse and experienced detumescence. He was admitted to our hospital on the next day. In both cases, magnetic resonance imaging (MRI) showed disruption of the tunica albuginea. We performed immediate surgical repair through localized incision...
September 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27746896/-recent-advances-in-managing-peyronie-s-disease
#11
Oliver Kayes, Rauf Khadr
Peyronie's disease remains an under-reported and debilitating problem which can result in significant physical and psychological symptoms for some men. The classic symptom complex includes penile curvature, penile plaque, and penile pain. Men can also present with erectile dysfunction, penile instability, and penile shortening, alongside feelings of low mood/libido, dysmorphobia, and low self-esteem. This review highlights the current key publications in the medical literature and provides updates on new clinical therapies whilst postulating about potential future treatments on the horizon...
2016: F1000Research
https://www.readbyqxmd.com/read/27561429/dermal-patch-graft-correction-of-severe-chordee-secondary-to-penile-corporal-body-disproportion-without-urethral-division-in-boys-without-hypospadias
#12
M R Zaontz, G E Dean
Historically, significant ventral penile curvature secondary to corporal body disproportion has been corrected either by dorsal plication or division of the urethral plate. In the rare situations where there is severe chordee in the face of an intact urethra with an orthotopic meatus, division of the urethral plate is commonly performed at the time of grafting the ventral defect created by incising the tunica albuginea. Subsequently, a staged procedure is necessary to reconnect the urethra at a later date. Herein the authors present a novel technique that shows it is possible to perform successful dermal patch orthoplasty without division of the urethra in patients with a normal orthotopic meatus and urethra via urethral mobilization...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27544298/review-of-management-options-for-patients-with-atypical-peyronie-s-disease
#13
Faysal A Yafi, Georgios Hatzichristodoulou, Kenneth J DeLay, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a wound-healing disorder of the tunica albuginea often associated with penile deformity. Less commonly, patients with PD might display atypical presentations such as ventral curvature, hourglass deformity, significantly shortened penis, and/or multiplanar curvature. AIM: To review the available literature on the prevalence of and management options for atypical PD. METHODS: A literature review was performed through PubMed from 1982 through 2016 regarding atypical PD...
August 17, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27511302/geometrical-modified-nesbit-corporoplasty-to-correct-different-types-of-penile-curvature-description-of-the-surgical-procedure-based-on-geometrical-principles-and-long-term-results
#14
P Vicini, S Di Nicola, G Antonini, E De Berardinis, V Gentile, F De Marco
We present the use of a modified corporoplasty, based on geometrical principles, to determine the exact site for the incision in the tunica or plaque and the exact amount of albuginea for overlaying to correct with extreme precision the different types of congenital or acquired penile curvature due to Peyronie's disease. To describe our experience with a new surgical procedure for the enhancement of penile curvature avoiding any overcorrection or undercorrection. Between March 2004 and April 2013, a total of 74 patients underwent the geometrical modified corporoplasty...
August 11, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27496771/adipocyte-accumulation-in-corpus-cavernosum-first-clinical-evidence-and-pathophysiological-implications-in-erectile-dysfunction
#15
J Vinay, J Sarquella, J Sanchez, F Algaba, I Gallegos, E Ruiz-Castañe, C Palma
OBJECTIVES: Animal models have shown that erectile dysfunction is associated with adipocyte accumulation under tunica albugínea, which could be involved in venous leakage and loss of penile rigidity. In the current sudy, we compared the histology of the penile sub-albuginean region of drug-refractory erectile dysfunction patients undergoing penile prosthesis implantation with potent patients with Peyronie's disease undergoing curvature correction procedures. MATERIALS AND METHODS: Seventeen refractory erectile dysfunction patients and fourteen potent patients with Peyronie's disease were recruited...
August 2, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27488311/correction-of-penile-ventral-curvature-in-patients-with-minor-or-no-hypospadias-a-single-surgeon-s-experience-of-43-cases
#16
Shogo Seo, Takanori Ochi, Yuta Yazaki, Hiroshi Murakami, Manabu Okawada, Takashi Doi, Go Miyano, Hiroyuki Koga, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: To report our experience of correcting penile ventral curvature associated with minor or no hypospadias. METHODS: We reviewed 43 penile ventral curvature patients treated by a single surgeon from 1997 to 2015. Of these, 23 had minor hypospadias. Curvature was corrected using degloving, chordectomy, dorsal plication (DP), tunica albuginea incision (TAI), or a combination of these. Outcome was confirmed by induced artificial erection and post-operative appearance...
October 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27486570/prevalence-psychological-impact-and-risk-factors-of-erectile-dysfunction-in-patients-with-peyronie-s-disease-a-retrospective-analysis-of-309-cases
#17
Gianni Paulis, Gennaro Romano, Andrea Paulis
Peyronie's disease (PD) is a chronic inflammatory disease involving the tunica albuginea of the penis. Erectile dysfunction (ED) is a possible invalidating symptom of PD. The aim of this study was to evaluate the prevalence, psychological impact, and risk factors of ED in patients with PD. The study was conducted by carrying out a retrospective analysis of the clinical records of 309 patients with PD who visited our andrology clinic. All patients underwent the following tests: body mass index, common blood tests and hormone assays, questionnaire for erectile function assessment, dynamic penile color Doppler ultrasonography, imaging of the penis at maximum erection with photographic poses according to Kelâmi, psychosexual impact evaluation with PD Questionnaire (symptom bother score), evaluation of depression symptoms with the Patient Health Questionnaire-9, and evaluation of the intensity of penile pain with the pain intensity numeric rating scale...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27450348/results-of-epispadias-repair-using-the-modified-cantwell-ransley-technique
#18
Yuval Bar-Yosef, Mario Sofer, Margaret P Ekstein, Yosef Binyamini, Jacob Ben-Chaim
OBJECTIVES: To evaluate our results of epispadias repair with a modified Cantwell-Ransley (MCR) technique. METHODS: A retrospective IRB-approved chart review of all patients who underwent an MCR epispadias repair was conducted between 1998-2015. Procedures were performed at birth or after the age of 8 months as part of the modern staged repair (MSR) of exstrophy-epispadias complex (EEC) in patients with bladder exstrophy treated since birth, at presentation for older patients, and after the age of 6 months in isolated epispadias patients...
July 20, 2016: Urology
https://www.readbyqxmd.com/read/27416671/-animal-models-of-peyronie-s-disease-an-update
#19
REVIEW
Jin-hong Li, Jiu-hong Yuan
Peyronie's disease is characterized by local fibrosis of the tunica albuginea and relatively rare clinically. Few relevant basic researches could be retrieved, which might be attributed to the absence of a robust animal model of the disease as well as to its rareness. At present, some animal models available for Peyronie's disease have their own merits and demerits. TGF-β1-induced and Fibrin-induced models are lack of penile curvature and calcification/ossification. A surgical model might be established for the acute phase of the disease...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/27377087/buccal-mucosa-is-a-promising-graft-in-peyronie-s-disease-surgery-our-experience-and-a-brief-literature-review-on-autologous-grafting-materials
#20
Andrea Fabiani, Lucilla Servi, Fabrizio Fioretti, Valentina Maurelli, Flavia Tombolini, Alessandra Filosa, Alessandro Zucchi, Gianni Paulis, Gabriele Mammana
AIM: Peyronie's Disease (PD) is an under reported acquired benign condition that, at the moment, is not curable with medical therapy. Surgery represent the gold standard of treatment. Surgical approaches are several and they consist in "plication techniques" or plaque incision/excision with grafting of resulting albuginea defect. Among grafting procedures, albuginea defect substitution with autologous materials demonstrated over the years not inferior results respect to heterologous grafts...
2016: Archivio Italiano di Urologia, Andrologia
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