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Peyronie disease

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https://www.readbyqxmd.com/read/29211402/sonographic-patterns-of-peyronie-s-disease-in-patients-with-absence-of-palpable-plaques
#1
Lucio Dell'Atti, Andrea Benedetto Galosi
PURPOSE: Non-palpable isolated septal plaques of the penis are likely present in a significant number of patients affected by erectile dysfunction (ED) and penile pain without deformity or curvature. The aim of this study was to evaluate the ultrasound (US) patterns observed in patients investigated for ED or penile pain without curvature. MATERIALS AND METHODS: We reviewed the medical records of 386 patients who underwent an initial colour-Doppler ultrasonography (CDU) of the penis for DE and/or penile pain without curvature...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29205179/commentary-on-nondegloving-technique-for-peyronie-s-disease-with-penile-prosthesis-implantation-and-double-dorsal-ventral-patch-graft
#2
Gerard D Henry, Kavina Jani
No abstract text is available yet for this article.
December 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29201230/inhibition-of-penile-tunica-albuginea-myofibroblasts-activity-by-adipose-derived-stem-cells
#3
Hesong Jiang, Qingqiang Gao, Xiaoyan Che, Leilei Zhu, Zheng Zhang, Yun Chen, Yutian Dai
The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of ADSCs in PD remain to be fully elucidated. In the present study, the inhibitory effects and possible mechanism of ADSCs on the activation of MFs derived from rat penile tunica albuginea were investigated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29195031/surgical-correction-of-peyronie-s-disease-via-tunica-albuginea-plication-long-term-follow-up
#4
M Seveso, S Melegari, O De Francesco, A Macchi, J Romero Otero, G Taverna, G Bozzini
Peyronie's disease (PD) is an acquired connective tissue disorder of the tunica albuginea with fibrosis and inflammation that lead to palpable plaques formation, penile curvature, and pain during erection. Patients report negative effects on main domains such as physical appearance and self-image, sexual function, and performance. The aim of this study was to evaluate plication of the albuginea outcomes after a long-term follow-up period. Between 1998 and 2006, a total of 204 patients with PD underwent surgical correction with albuginea plication technique...
December 1, 2017: Andrology
https://www.readbyqxmd.com/read/29184789/effect-of-collagenase-clostridium-histolyticum-on-penile-vascular-and-morphological-parameters-in-patients-with-peyronie-s-disease
#5
Linley Diao, James Anaissie, Hoang Minh Tue Nguyen, Faysal A Yafi, Nora M Haney, Kenneth J DeLay, Taylor C Peak, Suresh C Sikka, Wayne J G Hellstrom
Background: To examine the changes in penile vascular parameters after the administration of collagenase Clostridium histolyticum (CCH) in patients with Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017 who underwent penile duplex Doppler ultrasound (PDDU) after pharmacologically induced erection both before and after four cycles of CCH treatment. The primary outcomes measured were changes in peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) after CCH treatment...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29184788/racial-variations-in-response-to-intralesional-collagenase-clostridium-histolyticum-in-men-with-peyronie-s-disease
#6
Hoang Minh Tue Nguyen, Kenneth J DeLay, Linley Diao, Nora M Haney, James Anaissie, Faysal A Yafi, Suresh C Sikka, Wayne J G Hellstrom
Background: An examination of potential racial variations between Caucasian American (CA) and African American (AA) men in the efficacy and safety of collagenase clostridium histolyticum (CCH) in the treatment of Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017. Patients were divided into two groups based on their self-reported race. The primary outcomes of interest were final change in curvature after CCH treatment regardless of number of CCH cycles received, and frequency of treatment-related adverse events (TRAEs)...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29174623/conservatively-managed-peyronie-s-disease-long-term-survey-results-from-patients-electing-non-surgical-and-non-injection-therapies
#7
Matthew Ziegelmann, Raevti Bole, Ross Avant, David Yang, Brian Montgomery, Landon Trost
OBJECTIVE: To evaluate patient-reported temporal changes in penile curvature, pain, shortening, sexual function, and quality of life in men electing conservative treatment for PD. METHODS AND MATERIALS: Of 3,840 patients who underwent evaluation at our institution between 1990 and 2012, 719 were randomly selected to receive a mail-in questionnaire with topics including penile curvature, pain, shortening, sexual function, and quality of life. Men endorsing prior intralesional or surgical therapy were excluded...
November 21, 2017: Urology
https://www.readbyqxmd.com/read/29151107/repeated-micro-trauma-of-the-penile-tunica-albuginea-a-new-animal-model-of-peyronie-s-disease
#8
Hesong Jiang, Qingqiang Gao, Xiaoyan Che, Leilei Zhu, Zheng Zhang, Yun Chen, Yutian Dai
OBJECTIVES: To compare effects of repairing injured tunica albuginea (PTA) of rat penis by single or repeated local injections of chlorhexidine ethanol (ChE) into the PTA and to establish a new animal model of Peyronie's disease (PD). MATERIALS AND METHODS: Forty-two rats were divided into 7 groups. Rats either served as the normal control group with 1-5 injections of 0.9% saline or they received a single injection, 2, 3, 4, or 5 injections of ChE (0.1% chlorhexidine gluconate plus 15% ethanol dissolved in saline); rats in the positive control group were injected with TGF-β1...
November 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29144916/re-bicentric-prospective-evaluation-of-corporoplasty-with-porcine-small-intestinal-submucosa-sis-in-patients-with-severe-peyronie-s-disease
#9
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144915/re-safety-and-effectiveness-of-collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#10
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144914/re-factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-disease
#11
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144850/clinical-factors-negatively-impacting-sexual-relationships-in-men-with-peyronie-s-disease
#12
Matthew J Ziegelmann, Manaf Alom, Kevin Hebert, Ross Avant, Tobias Köhler, Landon Trost
Here, we sought to identify clinical factors associated with a negative impact on the relationship in Peyronie's Disease patients. During initial consultation, a detailed sexual questionnaire was administered, which included a question on whether or not PD negatively impacted the current sexual relationship. 146/242 (60.3%) patients reported that PD negatively impacted their sexual relationship. On multivariate analysis, penile shortening, partner pain with intercourse, and shorter relationship duration were associated with a negative relationship effect...
November 16, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29124870/defining-a-hba1c-value-that-predicts-increased-risk-of-penile-implant-infection
#13
Mohamad Habous, Raanan Tal, Tarek Soliman, Alaa Tealab, Mohammed Nassar, Zenhom Mekawi, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Hatem Kamr, Abdallah Remeah, Saleh Binsaleh, David Ralph, John Mulhall
OBJECTIVES: To explore the association between HbA1C level and penile implant infection rates and to define a cut-off value that predicted implant infection. PATIENTS AND METHODS: A multi center prospective study included all patients undergoing penile implant surgery between 2009-15. Preoperative, perioperative and postoperative management were identical for the entire cohort. Univariate analysis was performed to define predictors of implant infection. HbA1c levels were analyzed as a continuous variable and sequential analysis was conducted utilizing 0...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29072564/the-histopathological-effects-of-intracavernosal-mitomycin-c-injection-in-a-rat-peyronie-s-disease-model
#14
Engin Kaya, Yusuf Kibar, Sercan Yilmaz, Ayhan Ozcan, Burak Kopru, Turgay Ebiloglu, Hasan Cem Irkılata
INTRODUCTION: We aimed to evaluate whether or not nitomycin-C (MMC) has an anti-fibrotic effect on transforming growth factor beta (TGF-β)-induced Peyronie's disease (PD) in a rat model. METHODS: Eighteen 12-week-old male Sprague-Dawley rats were divided into three groups: Group 1= TGF-β1 (n:7); Group 2= TGF-β1+MMC (n:7); and Group 3= Sham group (0.25 ml bovine serum albumin injected) (n:4). All groups were sacrificed on the sixth week of the procedure and their penises were excised...
November 11, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29059762/re-small-intestinal-submucosa-grafting-for-peyronie-disease-outcomes-and-patient-satisfaction
#15
Allen F Morey
No abstract text is available yet for this article.
November 2017: Journal of Urology
https://www.readbyqxmd.com/read/29031427/-penile-prosthesis-implantation-indications-and-outcomes
#16
W Akakpo, K Ben-Naoum, D Carnicelli, L Ferretti, J-P Graziana, V Hupertan, E Huyghe, F X Madec, F Marcelli, C Methorst, N Morel-Journel, L Savareux, J E Terrier, R Yiou, A Faix
OBJECTIVE: Our aim was to present the indications and the outcomes of penile prosthesis implantation. METHODS: A literature review was performed through PubMed using the following keywords: penile implantation ; penile prosthesis; erectile dysfunction. RESULTS: Evolution of penile prosthesis devices led to get a fiable and effective treatment for men with erectile dysfunction who do not respond to less invasive therapy. Penile implant can also be useful in the treatment of Peyronie's disease, priapism and transgender surgery...
October 12, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28974406/treatment-of-peyronie-s-disease-with-collagenase-clostridium-histolyticum-and-vacuum-therapy-a-randomized-open-label-pilot-study
#17
David J Ralph, Amr Abdel Raheem, Genzhou Liu
BACKGROUND: Collagenase Clostridium histolyticum (CCH) is indicated for the treatment of penile curvature in adult men with Peyronie's disease (PD) with palpable plaque and curvature deformity of at least 30° at the start of therapy. AIM: To evaluate the efficacy and safety of CCH plus vacuum-pump therapy with and without penile modeling for the management of PD. METHODS: Adult men with PD and penile curvature of at least 30° were randomly assigned to receive CCH 0...
September 30, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28959941/nondegloving-technique-for-peyronie-s-disease-with-penile-prosthesis-implantation-and-double-dorsal-ventral-patch-graft
#18
Andrew Fang, Run Wang
No abstract text is available yet for this article.
September 29, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28952696/-buccal-mucosa-transplant-the-concept-of-ideal-graft-in-surgical-management-of-peyronies-disease
#19
S V Kotov, A G Yusufov, M K Semenov
INTRODUCTION: Surgical techniques in managing Peyronies disease include plication corporoplasty, plaque incision, grafting and penile prosthesis implantation. The question of an ideal transplant for corporoplasty remains open. AIM: To evaluate the effectiveness of the substitution corporoplasty using buccal mucosa transplant (BMT) in treating Peyronies disease. MATERIALS AND METHODS: From January 2011 to February 2016, 28 patients with stable stage Peyronies disease underwent substitution coroproplasty using BMT (incision and grafting)...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28923562/intralesional-injection-of-collagenase-clostridium-histolyticum-may-increase-the-risk-of-late-onset-penile-fracture
#20
REVIEW
Jonathan A Beilan, Jared J Wallen, Adam S Baumgarten, Kevin N Morgan, Justin L Parker, Rafael E Carrion
INTRODUCTION: The use of intralesional injection of collagenase Clostridium histolyticum (CCH) has become a valid treatment option in the management of Peyronie's disease (PD). Multiple studies have shown the drug's safety and efficacy. However, sparse literature exists on the utility of the injection protocol's 14-day "observation period," in which patients are instructed to abstain from all sexual activity. AIM: To summarize the contemporary literature and report on our series of patients treated with CCH in an effort to explore the effectiveness of the postinjection observation period...
September 8, 2017: Sexual Medicine Reviews
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