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Peyronie disease

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https://www.readbyqxmd.com/read/28721300/extracellular-matrix-alterations-in-the-peyronie-s-disease
#1
Marcelo Silva Watanabe, Thérèse Rachel Theodoro, Natália Lima Coelho, Aline Mendes, Monica Luzia Pereira Leonel, Ana Maria Mader, Helena Bonciani Nader, Sidney Glina, Maria Aparecida Silva Pinhal
Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individuals that presented a well-established disease, while control samples were obtained by biopsies of fresh cadavers. Immunohistochemistry analysis followed by digital quantification was performed to evaluate TGF-β, heparanases and metalloproteinases (MMPs)...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28718527/evaluation-of-intralesional-injection-of-hyaluronic-acid-compared-with-verapamil-in-peyronie-s-disease-preliminary-results-from-a-prospective-double-blinded-randomized-study
#2
V Favilla, G I Russo, A Zucchi, G Siracusa, S Privitera, S Cimino, M Madonia, T Cai, G Cavallini, G Liguori, G D'Achille, M Silvani, G Franco, P Verze, A Palmieri, B Torrisi, V Mirone, G Morgia
Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). This is a multi-centre prospective double-arm, randomized, double-blinded study comparing ILVI vs. intralesional HA after 12-weeks. Sexually active men, older than 18 years and affected by the acute phase of PD were eligible for this study...
July 2017: Andrology
https://www.readbyqxmd.com/read/28711404/penile-plication-with-or-without-degloving-of-the-penis-results-in-similar-outcomes
#3
Rustam Kadirov, Burhan Coskun, Onur Kaygisiz, Kadir Omur Gunseren, Yakup Kordan, Ismet Yavascaoglu, Hakan Kilicarslan
BACKGROUND: Penile plication techniques with or without degloving offer a minimally invasive option for the treatment of penile curvature. AIM: To review the outcomes of penile plication surgery and patient satisfaction with and without degloving of the penis. METHODS: We conducted a retrospective analysis of 52 patients who underwent penile plication for the treatment of Peyronie disease or congenital penile curvature. OUTCOMES: Surgical success rates, complications, and patient satisfaction determined with the Treatment Benefit Scale were compared between groups...
July 13, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28676223/prevalence-of-peyronie-s-disease-like-symptoms-in-men-presenting-with-dupuytren-contractures
#4
Alan W Shindel, Genevieve Sweet, William Thieu, Blythe Durbin-Johnson, Jennifer Rothschild, Robert Szabo
INTRODUCTION: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism. AIM: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC. METHODS: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. The survey assessed several basic demographic and sexual health factors and included items from the International Index of Erectile Function and the Erection Hardness Scale...
July 1, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28675171/sexual-dysfunction-shortened-cch-treatment-for-peyronie-s-disease
#5
Clemens Thoma
No abstract text is available yet for this article.
July 4, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28656928/dynamic-and-morphologic-evaluation-of-erectile-dysfunction-on-penile-doppler-sonography-and-contrast-cavernosography
#6
A Ismail, A M Tabari, S U Alhasan, A Abdullahi
BACKGROUND: Penile erection is a complex phenomenon that involves coordinated interaction of the psychologic, hormonal, nervous, arterial, venous, and sinusoidal systems. Erectile dysfunction (ED) is the persistent inability to attain or maintain penile erection sufficient for sexual intercourse. This study aims to determine the real-time morphologic vascular abnormalities in men with ED using penile Doppler sonography in Kano, Nigeria. MATERIALS AND METHODS: Twenty-one patients who were referred from urology clinics on account of suspected vasculogenic ED were reviewed...
June 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28612401/safety-and-effectiveness-of-collagenase-clostridium-histolyticum-cch-xiapex-%C3%A2-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#7
Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver George Ralph, Giulio Garaffa, Andrew Nim Christopher, David John Ralph
OBJECTIVES: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. PATIENTS AND METHODS: A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol...
June 14, 2017: BJU International
https://www.readbyqxmd.com/read/28590832/association-of-the-modified-frailty-index-with-adverse-outcomes-after-penile-prosthesis-implantation
#8
Khaled Madbouly, Dulaim AlHajeri, Mohamad Habous, Saleh Binsaleh
OBJECTIVES: To investigate frailty as a predictor of surgical outcome in elderly patients undergoing penile prosthesis implantation. MATERIAL AND METHODS: A total of 54 elderly patients, above 60 years of age, underwent penile prosthesis implantation between 2012 and 2014. Their data were collected and retrospectively analyzed. A modified frailty index (mFI) was calculated for each patient based on 11 risk factors from the Canadian Study of Health and Aging Frailty Index...
June 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28554517/factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-s-disease
#9
Ege C Serefoglu, Ted M Smith, Gregory J Kaufman, Genzhou Liu, Faysal A Yafi, Wayne J G Hellstrom
OBJECTIVE: To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie's disease (PD). METHODS: A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in two phase 3 trials of collagenase clostridium histolyticum (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies [IMPRESS-I; n = 417] and IMPRESS-II [n = 415])...
May 26, 2017: Urology
https://www.readbyqxmd.com/read/28540246/serious-complications-of-collagenase-clostridium-histiolyticum-injection-for-peyronie-s-disease-more-than-meets-the-eye
#10
EDITORIAL
Christopher Hobaugh, Alexander W Pastuszak
No abstract text is available yet for this article.
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28540240/collagenase-clostridium-hystolyticum-in-the-management-of-peyronie-s-disease
#11
EDITORIAL
Sun Tae Ahn, Du Geon Moon
No abstract text is available yet for this article.
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28522935/penile-ossification-a-reconstructive-challenge
#12
Arthi Satyanarayan, Nirmish Singla, Allen F Morey
Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Penile ossification remains a poorly understood, unusual entity that may pose a reconstructive challenge for urologists...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-disease
#13
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult men with penile curvature deformity <30°. CCH is indicated for treatment of Peyronie disease in adult men with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II) were included...
May 10, 2017: Urology
https://www.readbyqxmd.com/read/28483591/self-reported-clinical-meaningfulness-early-in-the-treatment-course-predicts-objective-outcomes-in-men-undergoing-collagenase-clostridium-histolyticum-injections-for-peyronie-s-disease
#14
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Mary E Westerman, Joshua B Savage, Landon W Trost
OBJECTIVE: To compare perceived meaningfulness early in the course of collagenase clostridium histolyticum (CCH) with final outcomes in order to evaluate its utility as a predictor of efficacy. METHODS: A registry of patients undergoing CCH from March 2014 to September 2016 was maintained. Patients were recommended to complete four injection-cycles. After each cycle, patients completed a questionnaire that included, "If you stopped at this point, would you consider this a meaningful improvement for you?" Curve assessments were performed prior to and at therapy completion...
May 5, 2017: Urology
https://www.readbyqxmd.com/read/28482350/does-transfer-capacitive-resistive-energy-has-a-therapeutic-effect-on-peyronie-s-disease-randomized-single-blind-sham-controlled-study-on-96-patients-fast-pain-relief
#15
Carlo Pavone, Salvatore Romeo, Francesco D'Amato, Manuela Usala, Giulia Letizia Mauro, Giovanni Caruana
Background/Aims/Objectives: We have investigated the clinical and physiological effects of Transfer Capacitive Resistive Energy (TCARE) therapy on men with Peyronie's disease (PD). METHODS: Ninety-six men with PD have been randomized in a 2:1 ratio to receive 3 sessions of TCARE therapy or sham therapy. Pain, penile curvature and erectile function have been assessed before the first treatment and up to 9 months after the end of treatment, using the Visual Analogue Scale for the pain, a goniometer to measure the degree of curvature using at-home photography and an International Index of Erectile Function (IIEF-5) questionnaire...
May 9, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28460995/three-dimensional-photography-for-quantitative-assessment-of-penile-volume-loss-deformities-in-peyronie-s-disease
#16
Ezra J Margolin, Carrie M Mlynarczyk, John P Mulhall, Doron S Stember, Peter J Stahl
BACKGROUND: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care. AIM: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters...
June 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28454897/collagenase-clostridium-histolyticum-in-the-treatment-of-urologic-disease-current-and-future-impact
#17
REVIEW
Andrew T Gabrielson, Jonathan T Spitz, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease...
April 25, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28395998/changes-in-the-effects-of-peyronie-s-disease-after-treatment-with-collagenase-clostridium-histolyticum-male-patients-and-their-female-partners
#18
Irwin Goldstein, L Dean Knoll, Larry I Lipshultz, Ted Smith, Gregory J Kaufman, Chris G McMahon
INTRODUCTION: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men. AIM: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners...
June 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28359407/role-of-interleukin-6-and-pentraxin-3-as-an-early-marker-in-peyronie-s-disease
#19
Arda Atar, Alev Kural, Gurkan Yenice, Ilker Comez, Volkan Tugcu
Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Plasma PTX3 and IL-6 concentrations were evaluated in 40 patients in the acute phase of PD and 40 healthy controls by enzyme-linked immunosorbent assay. Serum concentrations of both PTX3 and IL-6 were significantly higher in the PD patients than in the control group (p=0...
April 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28347795/clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#20
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Ross A Avant, Joshua B Savage, Landon W Trost
OBJECTIVE: To evaluate the outcomes in men undergoing collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie disease (PD). MATERIALS AND METHODS: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. A final curve assessment was performed after patients completed CCH. A prospective database was maintained, including patient-reported frequency and duration of PTT...
March 24, 2017: Urology
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