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Simple prostatectomy

Feng Li, Laura E Pascal, Jianhua Zhou, Yibin Zhou, Ke Wang, Anil V Parwani, Rajiv Dhir, Peng Guo, Dalin He, Joel B Nelson, Zhou Wang
The mechanisms involved in the development of benign prostatic hyperplasia (BPH) are poorly understood. One potential mechanism involved in BPH pathogenesis may involve altered expression of genes related to apoptosis and proliferation because reduced cell death and increased proliferation are thought to contribute to prostatic enlargement. This study examined the expression of B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (BCL-XL), two important anti-apoptosis factors that are also capable of inhibiting cell proliferation via accelerated G1 arrest or delayed G1/S transition, using immunostaining in simple prostatectomy BPH specimens from patients naïve to androgen manipulation...
2018: American Journal of Clinical and Experimental Urology
Randy Vince, Lance J Hampton, Mihai D Vartolomei, Shahrokh F Shariat, Francesco Porpiglia, Riccardo Autorino
PURPOSE OF REVIEW: Robotic assisted simple prostatectomy (RASP) represents a minimally invasive evolution of traditional open simple prostatectomy for the surgical treatment of severe lower urinary tract symptoms (LUTS) because of benign prostatic enlargement (BPE). Aim of the present review is to summarize the most recent evidence on this novel procedure, and to better define its current role in the surgical armamentarium for the treatment of BPE. RECENT FINDINGS: Several studies demonstrated that RASP can be safely and effectively performed in centers with sufficient expertise...
March 9, 2018: Current Opinion in Urology
V J Gnanapragasam, O Bratt, K Muir, L S Lee, H H Huang, P Stattin, A Lophatananon
BACKGROUND: The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer. METHODS: We applied a recently described five-strata model, the Cambridge Prognostic Groups (CPGs 1-5), in two international cohorts and tested prognostic performance against the current standard three-strata classification of low-, intermediate- or high-risk disease...
February 28, 2018: BMC Medicine
Ramalingam Manickam, Sivasankaran Nachimuthu, Senthil Kallappan, Mizar G Pai
Symptomatic benign prostatic hyperplasia (BPH) is managed medically worldwide, but transurethral resection of prostate (TURP) is the gold standard in refractory cases. Holmium laser enucleation of prostate (HoLEP), laser vaporization are other options which are widely practiced. However in larger glands which are more than 80 g, open adenomectomy is still practiced. Laparoscopic adenomectomy is a minimally invasive option in such circumstances. This article explains about different techniques in minimally invasive adenomectomy and the role for this procedure today...
January 2018: Asian Journal of Urology
Vincent Misraï, Marie Pasquie, Benoit Bordier, Benjamin Elman, Jean Michel Lhez, Julien Guillotreau, Kevin Zorn
PURPOSE: This study sought to compare perioperative outcomes and morbidities for open simple prostatectomy (OSP) and endoscopic green laser enucleation of the prostate (GreenLEP). METHODS: In a single department, all consecutive patients who underwent OSP between January 2005 and December 2010 were retrospectively reviewed, and all consecutive patients undergoing GreenLEP between July 2013 and January 2017 were prospectively enrolled. Perioperative data, information regarding early postoperative complications for up to 6 months and outcomes were collected and retrospectively compared...
January 25, 2018: World Journal of Urology
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
February 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Riccardo Bartoletti, Andrea Mogorovich, Francesco Francesca, Giorgio Pomara, Cesare Selli
BACKGROUND: To evaluate the effects of combined bladder neck preservation and posterior reconstruction techniques on early and long term urinary continence in patients treated by robotic assisted radical prostatectomy (RARP). METHODS: Two-hundred ninety-two patients who previously underwent radical prostatectomy were retrospectively selected for a case-control study, excluding those with anastomotic strictures and significant perioperative complications and re-called for a medical follow-up visit after their consent to participate the study...
December 15, 2017: BMC Urology
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
Yasmin Abu-Ghanem, Zohar Dotan, Jacob Ramon, Dorit E Zilberman
Retzius space sparing (RSS) during laparoscopic robot-assisted radical prostatectomy (RALP) has been offered as an approach that reduces perioperative complications and enables faster gaining of full urinary continence due to bladder anatomy preservation. Retro and transperitoneal techniques have been proposed, whereby RSS has been implemented. We sought to explore whether Retzius space reconstruction (RSR) following transperitoneal RALP will be an advantageous step as well. A prospective registry database of 102 consecutive transperitoneal RALP cases performed by a single surgeon was reviewed...
November 27, 2017: Journal of Robotic Surgery
Omer Burak Argun, Mustafa Bilal Tuna, Tünkut Doğanca, Can Obek, Panagiotis Mourmouris, Ilter Tufek, Sarper Erdogan, Bulent Cetinel, Ali Riza Kural
OBJECTIVE: To evaluate early continence rates with a novel modified vesico-urethral anastomosis technique based on prevention of urethral retraction using anastomosis sutures as stay sutures (PURS) during robot-assisted radical prostatectomy. MATERIAL AND METHOD: The modified anastomosis technique was used in 60 patients and data collected prospectively. This cohort was compared with another consecutive 60 patients operated with standard anastomosis technique. This new technique is based on preventing urethral retraction of the posterior urethra with 2 anastomosis sutures being used as stay sutures...
November 21, 2017: Journal of Endourology
Sarah C Vij, Ganesh Kartha, Venkatesh Krishnamurthi, Michelle Ponziano, Howard B Goldman
OBJECTIVE: To reduce our superficial surgical site infection rate (sSSI) following major urologic surgery by implementing a simple operating room bundle. METHODS: A simple operating room bundle was applied to all major urologic cases (cystectomy, nephrectomy and prostatectomy) at a single tertiary referral center. The bundle included allowing skin prep to dry appropriately, changing gloves prior to skin closure, irrigating the wound prior to skin closure and using a new separate sterile closing instrument set for skin closure...
November 6, 2017: Urology
Souichiro Ogawa, Seiji Hoshi, Tomoyuki Koguchi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Nobuhiro Haga, Yoshiyuki Kojima
INTRODUCTION: We present our experience with a novel 3-layer 2-step posterior reconstruction (PR) technique using peritoneum during robot-assisted radical prostatectomy (RARP) to improve recovery of postoperative urinary continence. METHODS: Forty-eight patients with localized prostate cancer were enrolled in this study and were divided randomly into 2 groups, which were treated by the standard PR technique (standard PR group; n=24) or the 3-layer PR technique using peritoneum (3-layer PR group; n=24) during RARP...
October 23, 2017: Journal of Endourology
Rafael Tourinho-Barbosa, Victor Srougi, Igor Nunes-Silva, Mohammed Baghdadi, Gregory Rembeyo, Sophie S Eiffel, Eric Barret, Francois Rozet, Marc Galiano, Xavier Cathelineau, Rafael Sanchez-Salas
BACKGROUND: Radical prostatectomy (RP) has been used as the main primary treatment for prostate cancer (PCa) for many years with excellent oncologic results. However, approximately 20-40% of those patients has failed to RP and presented biochemical recurrence (BCR). Prostatic specific antigen (PSA) has been the pivotal tool for recurrence diagnosis, but there is no consensus about the best PSA threshold to define BCR until this moment. The natural history of BCR after surgical procedure is highly variable, but it is important to distinguish biochemical and clinical recurrence and to find the correct timing to start multimodal treatment strategy...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Alejandro Garcia-Segui
OBJECTIVE: Laparoscopic adenomectomy (LA) is an effective procedure for the treatment of benign prostatic hyperplasia (BPH), which reproduces the surgical steps of the open adenomectomy (OA) by a minimally invasive approach to obtain the favorable results of open surgery in combination with the benefits offered by laparoscopic techniques. We performed a comprehensive bibliographic review of the technique and its current results in order to describe the evolution of the surgical technique and present the current evidence on the LA...
October 2017: Archivos Españoles de Urología
Muammer Altok, Mary F Achim, Surena F Matin, Curtis A Pettaway, Brian F Chapin, John W Davis
OBJECTIVES: As modern urology residency and fellowship training in robot-assisted surgery evolves toward standardized curricula (didactics, dry/wet-laboratory exercises, and surgical assistance), additional tools are needed to evaluate on-console performance. At the start of our robotics program in 2006, we set-up a time- and quality-based evaluation program and aim to consolidate this data into a simple set of metrics for self-evaluation. MATERIALS AND METHODS: Using our index procedure of robot-assisted radical prostatectomy (RARP), we prospectively collected data on 2,215 cases over 10 years from 6 faculty surgeons and 94 trainees (43 urologic oncology fellows and 51 urology residents)...
January 2018: Urologic Oncology
Igor Sorokin, Varun Sundaram, Nirmish Singla, Jordon Walker, Vitaly Margulis, Claus Roehrborn, Jeffrey C Gahan
OBJECTIVE: To report the largest comparative analysis of robotic vs open simple prostatectomy (OSP) for large-volume prostate glands. MATERIALS AND METHODS: We retrospectively reviewed 103 patients that underwent open and 64 patients that underwent robotic simple prostatectomy from 2012 to 2016 at a single institution. A propensity score-matched analysis was performed with five covariates, including age, body mass index, race, Charlson comorbidity index, and prostate volume...
November 2017: Journal of Endourology
Chandru P Sundaram
No abstract text is available yet for this article.
September 5, 2017: Journal of Endourology
Utku Lokman, Andrew M Erickson, Hanna Vasarainen, Antti S Rannikko, Tuomas Mirtti
BACKGROUND: Active surveillance (AS) is an option for men with low-risk prostate cancer (PCa). PTEN and ERG have been considered as potential biomarkers of PCa progression and survival. OBJECTIVE: To study the role of ERG and PTEN status in the Prostate Cancer Research International: Active Surveillance (PRIAS) trial diagnostic biopsies (DBxs) in predicting surveillance discontinuation and adverse surgical findings in subsequent radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: A total of 231 patients were recruited to the PRIAS between 2007 and 2013 in Helsinki...
March 22, 2017: European Urology Focus
Jamie N Holtz, Rachel Kloss Silverman, Kae Jack Tay, Jill T Browning, Jiaoti Huang, Thomas J Polascik, Rajan T Gupta
PURPOSE: Our objective is to determine the accuracy of multiparametric MRI (mpMRI) in predicting pathologic grade of prostate cancer (PCa) after radical prostatectomy (RP) using simple apparent diffusion coefficient metrics and, specifically, whether mpMRI can accurately separate disease into one of two risk categories (low vs. higher grade) or one of three risk categories (low, intermediate, or high grade) corresponding to the new prognostic grade group (PGG) criteria. METHODS: This retrospective, HIPAA-compliant, IRB-approved study included 140 patients with PCa who underwent 3 T mpMRI with endorectal coil and transrectal ultrasound-guided (TRUS-G) biopsy before RP...
July 18, 2017: Abdominal Radiology
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