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Adenoma of the prostate

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https://www.readbyqxmd.com/read/28092730/serum-agr2-as-a-useful-biomarker-for-pituitary-adenomas
#1
Mamatemin Tohti, Junyang Li, Chao Tang, Guodao Wen, Abdukeyum Abdujilil, Parhat Yizim, Chiyuan Ma
OBJECTIVE: This study aims to evaluate whether the serum Anterior Gradient-2 (AGR2) can be used as a potential biomarker screening in the diagnosis of Pituitary adenomas(PAs). PATIENTS AND METHODS: The serum AGR2 protein levels were preoperatively measured in 163 PA patients, 43 patients with other sellar lesions excluding PAs, 7 patients with prostate cancer as a positive control and 20 normal people(10 female and 10 male) using Enzyme-Linked ImmunoSorbent Assay (ELISA)...
January 9, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28087281/mtuepa-trans-urethral-monopolar-enucleation-of-prostatic-adenoma-preliminary-report
#2
Vito Pansadoro, Paolo Emiliozzi, Gianluca Del Vecchio, Marco Martini, Paolo Scarpone, Francesco Del Giudice, Domenico Veneziano, Aldo Brassetti, Christophe Assenmacher
OBJECTIVES: To describe preliminary results of our monopolar Transurethral Enucleation of Prostatic Adenoma (mTUEPA). METHODS: A consecutive series of patient treated with mTUEPA, a retrograde enucleation of the prostatic adenoma performed by means of a standard monopolar resectoscope, were prospectively enrolled. Symptoms, uroflometry parmeters and post voiding residual (PVR) were assessed at baseline and 1, 6 and 12 months post-operatively. Prostate volume (PV) was evaluated at baseline by means of transrectal ultrasound...
January 10, 2017: Urology
https://www.readbyqxmd.com/read/27997422/psma-expression-in-tumor-neovasculature-endothelial-cells-of-follicular-thyroid-adenoma-as-identified-by-molecular-imaging-using-68ga-psma-ligand-pet-ct
#3
Thorsten Derlin, Hans-Heinrich Kreipe, Udo Schumacher, Bisharah Soudah
The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease. Ga-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells...
December 16, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27994690/unusual-uptake-of-prostate-specific-tracer-68-ga-psma-hbed-cc-in-a-benign-thyroid-nodule
#4
Nishikant Avinash Damle, Madhavi Tripathi, Partha Sarathi Chakraborty, Manas Kumar Sahoo, Chandrasekhar Bal, Shipra Aggarwal, Geetanjali Arora, Praveen Kumar, Rajeev Kumar, Ravikant Gupta
(68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27987130/ultrasound-image-features-of-intravesical-prostatic-protrusion-indicated-failure-of-medication-therapy-of-finasteride-and-doxazosin-in-patients-with-benign-prostatic-hyperplasia-luts-bph
#5
Qiang Liu, Yunkai Zhu, Jianping Liu, Jun Qi, Jian Kang
BACKGROUND: Intravesical prostatic protrusion (IPP) is a type of benign prostatic hyperplasia (BPH) adenoma, and it plays a critical role in the pathogenesis of bladder outlet obstruction in patients with lower urinary tract syndromes (LUTS/BPH). AIMS: The goal of this study was to investigate the effect of a combination therapy with finasteride and doxazosin on IPP in BPU/LUTS patients. METHODS: A total of 322 BPH patients with enlarged prostatic volume as well as moderate to severe symptom scores were enrolled and divided into four groups according to the degree of IPP (IPP > 10 mm, 5-10 mm, <5 mm and no IPP) in this study...
December 16, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27966052/the-efficacy-and-safety-of-2-%C3%AE-m-continuous-laser-in-the-treatment-of-high-risk-patients-with-benign-prostatic-hyperplasia
#6
Wei Tao, Chuanyang Sun, Boxin Xue, Dongrong Yang, Mingchao Wang, Chunjie Cai, Yuxi Shan
Two-micrometer laser resection of prostate-tangerine technique dissects whole prostatic lobes off the surgical capsular, similar to peeling a tangerine. The present study aimed to evaluate the safety and efficacy of 2-μm continuous laser vaporization in the treatment of high-risk patients with benign prostatic hyperplasia (BPH) during the 24-month follow-up. The study included 248 patients with moderate to severe lower urinary tract symptoms who underwent 2-μm continuous laser vaporization of the prostate...
December 13, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27941719/study-of-prostatic-volume-and-its-variations-in-different-age-groups-of-bangladeshi-cadaver
#7
E Z Epsi, S Z Sultana, S Mannan, A S Azam, S Choudhury, Z Ahmed, S Farjan, A Kabir, M Ismatsara, M Yesmin, R S Zisa, S H Khan
Benign prostatic hyperplasia and carcinoma of the prostate are the most common disorders of Bangladeshi male in recent years. Volume of the prostate is necessary to estimate the amount of BPH adenoma to determine the appropriate therapy or to select the surgical approach. Transurethral resection of prostate (TURP) is preferred for small glands and open prostatectomy for larger ones. Decrease in prostatic mass after hormonal manipulation or radiation therapy can be used as an indicator of therapeutic efficacy...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27941372/early-and-delayed-18f-fch-pet-ct-imaging-in-parathyroid-adenomas
#8
Cecilia Vellani, Marina Hodolič, Spyridon Chytiris, Giuseppe Trifirò, Domenico Rubello, Patrick M Colletti
Preoperative localization with Tc-sestaMIBI or ultrasound is a common prerequisite for successful minimally invasive parathyroid adenoma (PA) surgery. SPECT/CT with Tc-sestaMIBI and PET/CT with F-FCH offer the possibility of attenuation correction and coregistration of functional and anatomical images providing more accurate PA localization. F-FCH PET/CT is used predominantly in patients with prostate cancer and is under investigation in PA. We report the case of a 43-year-old man with early FCH uptake in a cystic PA with delayed washout at 60 minutes...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27935821/stromal-hedgehog-signaling-maintains-smooth-muscle-and-hampers-micro-invasive-prostate-cancer
#9
Zhaohui Yang, Yu-Ching Peng, Anuradha Gopalan, Dong Gao, Yu Chen, Alexandra L Joyner
It is widely appreciated that reactive stroma or carcinoma-associated fibroblasts can influence epithelial tumor progression. In prostate cancer (PCa), the second most common male malignancy worldwide, the amount of reactive stroma is variable and has predictive value for tumor recurrence. By analyzing human PCa protein and RNA expression databases, we found smooth muscle cells (SMCs) are decreased in advanced tumors, whereas fibroblasts are maintained. In three mouse models of PCa, PB-MYC, ERG/PTEN and TRAMP, we found the composition of the stroma is distinct...
January 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27900218/a-prospective-randomised-controlled-study-comparing-bipolar-plasma-vaporisation-of-the-prostate-to-monopolar-transurethral-resection-of-the-prostate
#10
Ahmed M Elsakka, Hssan H Eltatawy, Khaled H Almekaty, Ahmed R Ramadan, Tarik A Gameel, Yasser Farahat
OBJECTIVES: To compare the safety and efficacy of bipolar transurethral plasma vaporisation (B-TUVP) as an alternative to the 'gold standard' monopolar transurethral resection of the prostate (M-TURP) for the treatment of benign prostatic hyperplasia (BPH) in a prospective randomised controlled study. PATIENTS AND METHODS: In all, 82 patients indicated for prostatectomy were assigned to two groups, group I (40 patients) underwent B-TUVP and group II (42 patients) underwent M-TURP...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27889177/-assessment-of-the-learning-curves-for-intravesical-adenoma-morcellation-using-piranha-%C3%A2-device-during-endoscopic-enucleation
#11
V Misrai, B Bordier, J Guillotreau
INTRODUCTION: Morcellation of intravesical adenoma (MIA) is an important part of the endoscopic enucleation procedure. The aim of this study was to analyse the learning curve of the MIA during endoscopic enucleation of the prostate. MATERIAL: We conducted a prospective study of the first 90 patients treated by endoscopic enucleation of the prostate by a single surgeon without previous experience of MIA. The population was divided into 3 consecutive groups of 30 patients...
November 23, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27888575/the-effect-of-fibrinogen-concentrate-on-perioperative-bleeding-in-transurethral-resection-of-the-prostate-a-double-blind-placebo-controlled-and-randomized-study
#12
Mohammad Soleimani, Navid Masoumi, Navid Nooraei, Alireza Lashay, Mohammad Reza Safarinejad
BACKGROUND: Hemorrhage during transurethral resection of the prostate (TUR-P) has always been a concern. Several studies have shown that pre-operative administration of fibrinogen concentrate has promising results in reducing hemorrhage in cardiac surgery. OBJECTIVES: This study investigated the hemostatic effect of fibrinogen concentrate administration on reducing the bleeding amount during TUR-P in patients with benign prostatic hyperplasia. METHODS: Sixty men with benign prostatic hyperplasia, who were chosen to undergo TUR-P, entered this prospective randomized double-blind placebo-controlled pilot study...
November 26, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27876137/cathepsin-k-the-association-between-cathepsin-k-expression-and-sphenoid-sinus-invasion-of-pituitary-adenomas
#13
Hongyan Liu, Guoqi Wang, Weijun Gu, Yiming Mu
Pituitary adenomas with sphenoid sinus or clivus invasion are not uncommon, but the pathogenesis responsible for this phenomenon remains unclear. Cathepsin K, expressed predominantly in osteoclasts, can degrade type I collagen and plays an essential role in bone resorption. Recent studies reported the expression of Cathepsin K in various malignant tumors, such as bone, breast, lung and prostate cancers, and its expression is further increased in bone metastasis or invasive subpopulations. In addition, cathepsin K inhibitors (CatKi) were demonstrated to effectively prevent or reduce osteolytic lesions in breast cancers with bone metastasis...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27800470/holmium-laser-enucleation-of-the-prostate-patient-selection-and-perspectives
#14
REVIEW
Tracy Marien, Mustafa Kadihasanoglu, Nicole L Miller
BACKGROUND: Multiple endoscopic surgical options exist to treat benign prostatic hyperplasia (BPH), including holmium laser enucleation of the prostate (HoLEP). HoLEP alleviates obstructive prostatic tissue via enucleation, both bluntly with a resectoscope and by cutting tissue with the holmium laser, and removal of adenoma via morcellation. This article reviews patient selection for HoLEP in order to optimize outcomes, costs, and patient satisfaction. METHODS: A literature review of all studies on HoLEP was conducted...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27777235/colorectal-adenomas-in-participants-of-the-select-randomized-trial-of-selenium-and-vitamin-e-for-prostate-cancer-prevention
#15
Peter Lance, David S Alberts, Patricia A Thompson, Liane Fales, Fang Wang, Jerilyn San Jose, Elizabeth T Jacobs, Phyllis J Goodman, Amy K Darke, Monica Yee, Lori Minasian, Ian M Thompson, Denise J Roe
Selenium and vitamin E micronutrients have been advocated for the prevention of colorectal cancer. Colorectal adenoma occurrence was used as a surrogate for colorectal cancer in an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT) for prostate cancer prevention. The primary objective was to measure the effect of selenium (as selenomethionine) on colorectal adenomas occurrence, with the effect of vitamin E (as α-tocopherol) supplementation on colorectal adenoma occurrence considered as a secondary objective...
January 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/27692588/use-of-a-machine-learning-method-for-predicting-highly-cited-articles-within-general-radiology-journals
#16
Andrew B Rosenkrantz, Ankur M Doshi, Luke A Ginocchio, Yindalon Aphinyanaphongs
RATIONALE AND OBJECTIVES: This study aimed to assess the performance of a text classification machine-learning model in predicting highly cited articles within the recent radiological literature and to identify the model's most influential article features. MATERIALS AND METHODS: We downloaded from PubMed the title, abstract, and medical subject heading terms for 10,065 articles published in 25 general radiology journals in 2012 and 2013. Three machine-learning models were applied to predict the top 10% of included articles in terms of the number of citations to the article in 2014 (reflecting the 2-year time window in conventional impact factor calculations)...
December 2016: Academic Radiology
https://www.readbyqxmd.com/read/27685924/high-incidence-of-thyroid-cancer-among-patients-with-acromegaly
#17
Dimitrios Kaldrymidis, Georgios Papadakis, Georgios Tsakonas, Philippos Kaldrymidis, Theofanis Flaskas, Andreas Seretis, Eleni Pantazi, Ifigenia Kostoglou-Athanassiou, Melpomeni Peppa, Paraskevi Roussou, Evanthia Diamanti-Kandarakis
PURPOSE: Several studies have suggested that patients with acromegaly have an increased risk of thyroid, colorectal, breast and prostate cancers. In this study we determined the prevalence of malignant neoplasms in patients with acromegaly. METHODS: Cancer risk was evaluated in a cohort of 110 patients (M/F 48/62, age 58.63±13.8 years, range 30-86) with acromegaly. Mean age at diagnosis of acromegaly was 46.37±13.11 years. Mean period of time since diagnosis of acromegaly was 12...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27676715/bladder-rupture-secondary-to-emphysematous-bladder-a-diabetic-patient-report
#18
Astrid Balança
OBJECTIVE: We report an emphysematous cystitis in a diabetic patient complicated by peritonitis. OBSERVATIONS: A 66-year-old male presented to the emergency with septic shock. Patient's history: poorly controlled diabetes and prostate adenoma. Clinical examination revealed a surgical abdomen and signs of shock. Blood sugar was 6g/L. CRP 274mg/L. The abdomino-pelvic CT scan showed a perforated bladder with emphysema of the bladder wall and endoluminal air bubbles...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27672332/prostate-cancer-patients-may-have-an-increased-risk-of-coexisting-advanced-colorectal-neoplasms
#19
Sun-Hye Ko, Myong Ki Baeg, Woong Jin Bae, Pumsoo Kim, Myung-Gyu Choi
BACKGROUND/AIMS: Patients being treated for prostate cancer (PCa) have an increased risk of developing colorectal cancer. However, whether PCa patients are inherently at a higher risk of colorectal neoplasms (CRNs) is unknown. We aimed to investigate the risk of CRNs in PCa patients. MATERIALS AND METHODS: Patients who had been diagnosed with PCa at a tertiary medical center and had colonoscopy within 1 year of the PCa diagnosis were investigated. Patients were propensity-matched 1:2 by age and body mass index to asymptomatic control subjects who had undergone colonoscopy for routine health screening...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27635065/the-prostate-lung-colorectal-and-ovarian-cancer-plco-screening-trial-pathology-tissue-resource
#20
Claire S Zhu, Wen-Yi Huang, Paul F Pinsky, Christine D Berg, Mark Sherman, Kelly J Yu, Danielle M Carrick, Amanda Black, Robert Hoover, Petra Lenz, Craig Williams, Laura Hawkins, Matthew Chaloux, Susan Yurgalevitch, Sunitha Mathew, Amy Miller, Vanessa Olivo, Asia Khan, Shannon M Pretzel, Deborah Multerer, Patricia Beckmann, Karen G Broski, Neal D Freedman
BACKGROUND: Pathology tissue specimens with associated epidemiologic and clinical data are valuable for cancer research. The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial undertook a large-scale effort to create a public resource of pathology tissues from PLCO participants who developed a cancer during the trial. METHODS: Formalin-fixed paraffin-embedded tissue blocks were obtained from pathology laboratories on a loan basis for central processing of tissue microarrays, with additional free-standing tissue cores collected for nucleic acid extraction...
December 2016: Cancer Epidemiology, Biomarkers & Prevention
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