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Adenoma of the prostate

Karan Lal, Travis J Morrell, Michael Cunningham, Patrick OʼDonnell, Nikki A Levin, Kristine M Cornejo
Cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of pleomorphic adenoma of salivary glands, comprised of both epithelial and mesenchymal components. Malignant transformation is exceptionally rare, with only a few cases reported. We report a case of a malignant cutaneous mixed tumor in an 86-year-old white man who presented with a pink indurated plaque on his left scapula. He had a history of nonmelanoma skin cancers, a stage IB malignant melanoma of a lower extremity and Gleason 4 + 3 prostate cancer treated with brachytherapy, external beam irradiation, and bicalutamide...
March 6, 2018: American Journal of Dermatopathology
Birthe Heitkötter, Konrad Steinestel, Marcel Trautmann, Inga Grünewald, Peter Barth, Heidrun Gevensleben, Martin Bögemann, Eva Wardelmann, Wolfgang Hartmann, Kambiz Rahbar, Sebastian Huss
Aim: PSMA (prostate-specific membrane antigen) is physiologically expressed in normal prostate tissue and over expressed in prostate cancer cells, therefore constituting a potential target for antibody-based radioligand therapy. Very recent imaging findings reported PSMA-PET/CT uptake in various thyroid lesions. We were therefore encouraged to systematically analyse PSMA expression in different benign and malignant thyroid lesions. Methods: Immunohistochemistry was used to detect PSMA expression in 101 thyroid lesions, while neovasculature was identified by CD34 immunostaining...
February 9, 2018: Oncotarget
Lei Yan, Shenon Sethi, Pincas Bitterman, Vijaya Reddy, Paolo Gattuso
BACKGROUND: Umbilical lesions are rare, and can be benign or malignant. This retrospective study was conducted to assess the epidemiological, clinical, and histologic characteristics of umbilical masses. METHODS: Cases of umbilical masses from January 1994 to August 2016 were retrieved from our institution's pathology databases, and their clinicopathological features were reviewed. RESULTS: There were a total of 99 cases of umbilical masses, 78 women (78...
February 1, 2018: International Journal of Surgical Pathology
E E Rosenberg, G V Gerashchenko, N V Hryshchenko, L V Mevs, K A Nekrasov, R A Lytvynenko, Y V Vitruk, O P Gryzodub, E A Stakhovsky, V I Kashuba
BACKGROUND:  Prostate cancer is one of the most common male cancers in Western countries and takes the third place in morbidity in Ukraine. It is a highly heterogeneous disease. AIM: To analyze relative expression levels of the TGFB1, IL1B, FOS, EFNA5, TAGLN, PLAU, and EPDR1 genes in malignant and non-malignant prostate tissues. MATERIALS AND METHODS:  Total RNA was isolated from 16 prostate adenomas, 37 prostate adenocarcinomas, and 29 conventionally normal prostate tissues...
July 2017: Experimental Oncology
Han Jie Lee, Alvin Lee, Hong Hong Huang, Palaniappan Sundaram, Keong Tatt Foo
Objective: Despite high-grade intravesical prostatic protrusion (IPP) being closely related to bladder outlet obstruction (BOO), up to 21% of patients with low IPP remain obstructed. This study evaluates the characteristics and urodynamic findings of men with small prostates and low IPP. Methods: One hundred and fourteen men aged >50 years old with lower urinary tract symptoms (LUTS) were assessed with symptoms, uroflowmetry, serum prostate-specific antigen (PSA), transabdominal ultrasound measurement of prostate volume (PV), IPP and post-void residual urine (PVRU)...
October 2017: Asian Journal of Urology
Ramalingam Manickam, Sivasankaran Nachimuthu, Senthil Kallappan, Mizar G Pai
Symptomatic benign prostatic hyperplasia (BPH) is managed medically worldwide, but transurethral resection of prostate (TURP) is the gold standard in refractory cases. Holmium laser enucleation of prostate (HoLEP), laser vaporization are other options which are widely practiced. However in larger glands which are more than 80 g, open adenomectomy is still practiced. Laparoscopic adenomectomy is a minimally invasive option in such circumstances. This article explains about different techniques in minimally invasive adenomectomy and the role for this procedure today...
January 2018: Asian Journal of Urology
I N Orlov, S V Popov, A G Martov, E A Gallyamov, S M Malevich, I V Sushina, E A Grin, A E Sanzharov, A B Novikov, V P Sergeev, A D Kochkin
AIM: To compare holmium laser enucleation of the prostate (HoLEP) and endovideosurgical (EVS) adenomectomy in the treatment of prostate adenoma. MATERIALS AND METHODS: We compared treatment results of 180 patients with prostate adenomas greater than 100 cm3 who underwent EVS adenomectomy (n=90) and laser enucleation of the prostate (n=90). The analysis included the following parameters: duration of catheterization, length of postoperative hospital stay, I-PSS score, maximum urinary flow rate measured by uroflowmetry and complications according to Clavien-Dindo grading systems...
December 2017: Urologii︠a︡
C Lanchon, G Fiard, J-A Long, V Arnoux, D Carnicelli, Q Franquet, D Poncet, E Bey, J-B Lefrancq, S Grisard, N Peilleron, N Terrier, B Boillot, J-J Rambeaud, J-L Descotes, C Thuillier
INTRODUCTION: GreenLight photoselective vaporisation of the prostate (PVP) offers an endoscopic alternative to open prostatectomy (OP) for treatment of large adenomas. This study compares long-term functional outcome of both techniques in patients with Benign prostatic obstruction (BPO)>80g. MATERIAL AND METHOD: Data from patients who underwent surgical treatment for BPO>80g from January 2010 to February 2015 at our institution were retrospectively collected and compared according to surgical technique...
January 9, 2018: Progrès en Urologie
Konrad Wilhelm, Ioana Maria Cazana, Martin Schoenthaler, Arndt Katzenwadel, Johannes Spaeth, Arkadiusz Miernik
PURPOSE: To evaluate long-term efficacy and safety of low-pressure transurethral resection of the prostate for prostates < 70 cc (group 1) vs. > 70 cc (group 2). PATIENTS AND METHODS: In this study patients operated with monopolar TURP between 2009 and 2012 were evaluated retrospectively. During surgery a specially designed trocar (18 Fr) was placed suprapubically and connected to a suction pump to maintain stable low-pressure conditions. After sample size calculations, long-term follow-up was completed for 70 invited patients in each group up to 9/2015...
January 6, 2018: World Journal of Urology
Alyson Haslam, Sara Wagner Robb, James R Hébert, Hanwen Huang, Mark H Ebell
AIM: The purpose of the current study is to examine the dietary patterns in a diverse cohort of individuals and to see if the identified dietary patterns predict the prevalence of adenoma in a cross-sectional study. METHODS: Factor analysis was used to derive both sex- and population subgroup-specific dietary patterns among participants in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Logistic regression was used to assess associations between identified factor scores and colorectal adenoma (CRA) in sex-specific subgroups...
December 26, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
Alyson Haslam, Sara Wagner Robb, James R Hébert, Hanwen Huang, Mark H Ebell
To examine potential racial differences in Mediterranean diet scores and whether these differences are associated with the prevalence of colorectal adenoma (CRA), a cross-sectional analysis of data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial was performed. The authors hypothesize that people consuming a more Mediterranean-like diet have lower odds of CRA. Flexible sigmoidoscopy was used to determine the presence of colorectal adenoma. Mediterranean diet scores were calculated from food frequency questionnaire responses...
December 2017: Nutrition Research
Waleed El-Shaer, Ahmed Abou-Taleb, Wael Kandeel
Objectives: To assess the safety and efficacy of bipolar plasmakinetic enucleation and resection of the prostate (PKERP) for the management of benign prostatic hyperplasia (BPH) in patients on oral anticoagulant (OAC) therapy and/or platelet aggregation inhibitors (PAIs). Patients and methods: In all, 91 patients were recruited and underwent PKERP whilst they were receiving PAIs (aspirin, 56 patients; clopidogrel, three; aspirin and clopidogrel, 11). In all, 15 patients were receiving an OAC drug perioperatively, whilst another six patients were on dual PAIs and OACs...
December 2017: Arab Journal of Urology
Marco Dellabella, Daniele Castellani
OBJECTIVE: To present our 2-lobe technique of thulium laser transurethral enucleation of the prostate. Transurethral resection of prostate and open prostatectomy have been traditionally considered as the gold standard for benign prostatic enlargement surgical treatment. Laser has been recently made available for benign prostatic enlargement surgery to minimize morbidity of traditional surgery.1 In 2009, Bach et al introduced the use of thulium laser,2 describing the 3-lobe technique, which overlaps open prostatectomy but with a greater control of hemostasis...
December 7, 2017: Urology
Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Nobutaka Mukumoto, Megumi Uto, Kiyonao Nakamura, Takashi Mizowaki, Masahiro Hiraoka
PURPOSE: To conduct patient-specific geometric and dosimetric quality assurance (QA) for the Dynamic WaveArc (DWA) using logfiles and ArcCHECK (Sun Nuclear Inc., Melbourne, FL, USA). METHODS: Twenty DWA plans, 10 for pituitary adenoma and 10 for prostate cancer, were created using RayStation version 4.7 (RaySearch Laboratories, Stockholm, Sweden). Root mean square errors (RMSEs) between the actual and planned values in the logfiles were evaluated. Next, the dose distributions were reconstructed based on the logfiles...
November 2017: Physica Medica: PM
Ahmad Parvinian, Erica L Martin-Macintosh, Ajit H Goenka, Jolanta M Durski, Brian P Mullan, Brad J Kemp, Geoffrey B Johnson
OBJECTIVE: The purpose of this study is to determine the efficacy of (11)C-choline PET/CT for the detection of parathyroid adenomas by retrospectively reviewing a large patient population. MATERIALS AND METHODS: In this single-institution retrospective study, 7088 (11)C-choline PET/CT scans performed of 2933 men with prostate cancer from January 2005 through February 2016 were evaluated. Patients with suspected parathyroid adenomas were identified through a review of the electronic medical record and relevant imaging...
November 15, 2017: AJR. American Journal of Roentgenology
Petrit Nuraj, Nexhmi Hyseni
Background: The obstructive hydronephrosis is a term that implicates the structural and functional changes of the kidneys as a result of difficulties in the flow of urine. Hydronephrosis specifically describes dilation and swelling of the kidney. Hydronephrosis is a condition that typically occurs when the kidney swells due to the failure of normal drainage of urine from the kidney to the bladder. Our aim was to evaluate the degree of hydronephrosis, causes and diagnostic method. Material and...
September 2017: Acta Informatica Medica: AIM
Anuj Deep Dangi, Ramya Nagarajan, Arabind Panda, Ramani Manoj Kumar, Antony Devasia, Nitin Kekre
Introduction: There is contradictory evidence in literature with respect to the association of asymptomatic prostatic inflammation on biopsy with complications of Transurethral Resection of Prostate. The aim of the present study was to evaluate the association of prostatitis in biopsy specimens of patients undergoing transurethral resection of prostate with bladder neck contracture (the primary end point) and other complications. Material and methods: Patients who had undergone transurethral resection at a single centre between 2005 and 2010, with a minimum of 3 months follow-up were included...
2017: Central European Journal of Urology
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
Gwendolyn Fernandes, Shital Munde, Amey Rojekar
Villous adenomas of the urinary tract are uncommon neoplasms which share similar morphological features with gastrointestinal villous adenomas. Only two case series and around 20 scattered case reports of villous adenoma in the urinary tract have been published in English literature till date. They have been identified mainly in the urinary bladder, urethra, prostate and urachus, but the occurrence of villous adenomas at the vesicoureteric junction has not been described. We present a case of villous adenoma of the vesicoureteric junction which completely occluded the lumen and led to gross pyonephrosis...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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