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Magnetic resonance imaging NSCLC

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https://www.readbyqxmd.com/read/28253364/comparison-of-18f-fdg-pet-ct-and-dwi-for-detection-of-mediastinal-nodal-metastasis-in-non-small-cell-lung-cancer-a-meta-analysis
#1
Guohua Shen, You Lan, Kan Zhang, Pengwei Ren, Zhiyun Jia
BACKGROUND: Accurate clinical staging of mediastinal lymph nodes of patients with lung cancer is important in determining therapeutic options and prognoses. We aimed to compare the diagnostic performance of diffusion-weighted magnetic resonance imaging (DWI) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in detecting mediastinal nodal metastasis of lung cancer. METHODS: Relevant studies were systematically searched in the MEDLINE, EMBASE, PUBMED, and Cochrane Library databases...
2017: PloS One
https://www.readbyqxmd.com/read/28225485/magnetic-resonance-mr-imaging-for-tumor-staging-and-definition-of-tumor-volumes-on-radiation-treatment-planning-in-nonsmall-cell-lung-cancer-a-prospective-radiographic-cohort-study-of-single-center-clinical-outcome
#2
COMPARATIVE STUDY
Dan Zhao, Qiaoqiao Hu, Liping Qi, Juan Wang, Hao Wu, Guangying Zhu, Huiming Yu
We investigate the impact of magnetic resonance (MR) on the staging and radiotherapy planning for patients with nonsmall cell lung cancer (NSCLC).A total of 24 patients with NSCLC underwent MRI, which was fused with radiotherapy planning CT using rigid registration. Gross tumor volume (GTV) was delineated not only according to CT image alone (GTVCT), but also based on both CT and MR image (GTVCT/MR). For each patient, 2 conformal treatment plans were made according to GTVCT and GTVCT/MR, respectively. Dose-volume histograms (DVH) for lesion and normal organs were generated using both GTVCT and GTVCT/MR treatment plans...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28101700/predicting-brain-metastases-for-non-small-cell-lung-cancer-based-on-magnetic-resonance-imaging
#3
Gang Yin, Churong Li, Heng Chen, Yangkun Luo, Lucia Clara Orlandini, Pei Wang, Jinyi Lang
In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent validation and verification of the model. Magnetic resonance images were segmented into cerebrospinal fluid, gray matter (GM), and white matter using voxel-based morphometry. Automatic anatomic labeling template was used to extract 116 brain regions from the GM volume...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28074321/predictive-factors-of-early-distant-brain-failure-after-gamma-knife-radiosurgery-alone-in-patients-with-brain-metastases-of-non-small-cell-lung-cancer
#4
Young Cheol Na, Hyun Ho Jung, Hye Ryun Kim, Byoung Chul Cho, Jin Woo Chang, Yong Gou Park, Won Seok Chang
The objective of this study was to elucidate the predictive factors for early distant brain failure in patients with brain metastases of non-small-cell lung cancer (NSCLC) who were treated with gamma knife radiosurgery (GKRS) without previous whole-brain radiotherapy (WBRT) or surgery. We retrospectively reviewed clinical and imaging data of 459 patients with brain metastases of NSCLC who underwent GKRS from June 2008 to December 2013. The primary end-point was early distant brain failure, defined as the detection of newly developed metastatic lesions on magnetic resonance imaging (MRI) 3 months after GKRS...
January 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28050694/survival-prediction-using-temporal-muscle-thickness-measurements-on-cranial-magnetic-resonance-images-in-patients-with-newly-diagnosed-brain-metastases
#5
Julia Furtner, Anna S Berghoff, Omar M Albtoush, Ramona Woitek, Ulrika Asenbaum, Daniela Prayer, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Bernadette Aretin, Rupert Bartsch, Christoph C Zielinski, Veronika Schöpf, Matthias Preusser
OBJECTIVES: To evaluate the prognostic relevance of temporal muscle thickness (TMT) in brain metastasis patients. METHODS: We retrospectively analysed TMT on magnetic resonance (MR) images at diagnosis of brain metastasis in two independent cohorts of 188 breast cancer (BC) and 247 non-small cell lung cancer (NSCLC) patients (overall: 435 patients). RESULTS: Survival analysis using a Cox regression model showed a reduced risk of death by 19% with every additional millimetre of baseline TMT in the BC cohort and by 24% in the NSCLC cohort...
January 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28046421/su-c-bra-02-a-lung-tumor-autocontouring-algorithm-based-on-particle-filter-for-dynamic-magnetic-resonance
#6
A Bourque, S Bedwani, E Filion, J Carrier
PURPOSE: This study proposes a novel autocontouring algorithm for lung tumors based on particle filter. It is developed in the context of MR-linac treatments and is validated on in-vivo dynamic magnetic resonance images. METHODS: A sequential Monte Carlo method called particle filter is combined with Otsu's thresholding technique to contour lung tumors on dynamic MR images. Four non-small cell lung cancer (NSCLC) patients were imaged with a 1.5 T MR (MAGNETOM Aera, Siemens Healthcare, Erlangen, Germany) for one minute at a rate of 4 images per second...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27807951/complete-remission-of-liver-metastasis-in-a-lung-cancer-patient-with-epidermal-growth-factor-mutation-achieved-with-icotinib
#7
Zhouyu Zhu, Ying Chai
A 65-year-old Chinese male was referred to our hospital for epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). Aggressive combined therapy with surgical resection of the right upper lung lesion and chemotherapy was performed. One month later, continued Icotinib treatment was used as magnetic resonance imaging revealed liver metastasis (LM). Interestingly, complete remission of the patient's LM lesions was achieved in six months. To our knowledge, this is the first report documenting a successful case of an NSCLC patient with LM treated with Icotinib after receiving a radical resection for pulmonary carcinoma...
November 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27674804/magnetic-resonance-imaging-brain-staging-in-stage-i-iii-non-small-cell-lung-cancer-nsclc-incidence-and-clinicopathologic-factors-in-asymptomatic-brain-metastases-at-diagnosis
#8
S R Rice, J K Molitoris, M Vyfhuis, P Mohindra, J Feliciano, S N Badiyan, E M Nichols, M J Edelman, J Friedberg, W Burrows, S J Feigenberg
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27612171/the-impact-of-diffusion-weighted-mri-on-the-definition-of-gross-tumor-volume-in-radiotherapy-of-non-small-cell-lung-cancer
#9
Jochen Fleckenstein, Michael Jelden, Stephanie Kremp, Philippe Jagoda, Jonas Stroeder, Fadi Khreish, Samer Ezziddin, Arno Buecker, Christian Rübe, Guenther K Schneider
OBJECTIVE: The study was designed to evaluate diffusion-weighted magnetic resonance imaging (DWI) vs. PET-CT of the thorax in the determination of gross tumor volume (GTV) in radiotherapy planning of non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: Eligible patients with NSCLC who were supposed to receive definitive radio(chemo)therapy were prospectively recruited. For MRI, a respiratory gated T2-weighted sequence in axial orientation and non-gated DWI (b = 0, 800, 1,400 and apparent diffusion coefficient map [ADC]) were acquired on a 1...
2016: PloS One
https://www.readbyqxmd.com/read/27587046/a-particle-filter-based-autocontouring-algorithm-for-lung-tumor-tracking-using-dynamic-magnetic-resonance-imaging
#10
Alexandra E Bourque, Stéphane Bedwani, Édith Filion, Jean-François Carrier
PURPOSE: This study introduces a novel autocontouring algorithm based on particle filter for lung tumors. It is validated on dynamic magnetic resonance (MR) images and is developed in the context of MR-linac treatments. METHODS: A sequential Monte Carlo method called particle filter is used as the main structure of the algorithm and is combined with Otsu's thresholding technique to contour lung tumors on dynamic MR images. Four non-small cell lung cancer (NSCLC) patients were imaged with a 1...
September 2016: Medical Physics
https://www.readbyqxmd.com/read/27561805/-clinical-features-of-intradural-extramedullary-spinal-cord-metastases-%C3%A2-in-primary-lung-cancer
#11
Yan Xu, Wei Zhong, Jing Zhao, Minjiang Chen, Longyun Li, Mengzhao Wang
BACKGROUND: Intradural extramedullary spinal cord metastases in lung cancer is rare, and it leads to severe neurological damage. The aim of this study is to identify the clinical features of intradural extramedullary spinal cord metastases in primary lung cancer patients. METHODS: The 8 cases of lung cancer with intradural extramedullary metastases, who were hospitalized in Peking Union Medical College Hospital (PUMCH) during May 2013 to May 2016, were enrolled in the retrospective study...
August 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27561804/-analysis-of-clinicopathological-feature-and-prognosis-for-%C3%A2-leptomeningeal-metastasis-in-non-small-cell-lung-cancer
#12
Min Zhu, Yanhong Ren, Yan Liu, Chengjun Ban, Hua Gu, Zheng Wang, Yuhui Zhang
BACKGROUND: Leptomeningeal metastases (LM) is one of the most serious complications of advanced non-small cell lung cancer (NSCLC) due to the lower quality of life and poor prognosis. The aim of this study is to analyze the clinicopathological features and prognosis of patients with LM from NSCLC (NSCLC-LM). METHODS: Clinical data of 3 patients with NSCLC-LM collected from January 2015 to June 2016 were analyzed with a brief review. RESULTS: All 3 patients had adenocarcinoma histology harboring epidermal growth factor receptor (EGFR) exon 21 point mutations (m)...
August 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27542716/oligo-recurrence-predicts-favorable-prognosis-of-brain-only-oligometastases-in-patients-with-non-small-cell-lung-cancer-treated-with-stereotactic-radiosurgery-or-stereotactic-radiotherapy-a-multi-institutional-study-of-61-subjects
#13
Yuzuru Niibe, Tetsuo Nishimura, Tetsuya Inoue, Katsuyuki Karasawa, Yoshiyuki Shioyama, Keiichi Jingu, Hiroki Shirato
BACKGROUND: To investigate the prognostic value of oligo-recurrence in patients with brain-only oligometastases of non-small cell lung cancer (NSCLC) treated with stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT). METHODS: Patients treated with SRS or SRT for brain-only NSCLC oligometastases in 6 high-volume institutions in Japan between 1996 and 2008 were reviewed. Eligible patients met 1), 2), and 4) or 1), 3), and 4) of the following: 1) NSCLC with 1 to 4 brain metastases on magnetic resonance imaging (MRI) treated with SRS or SRT; 2) control of the primary lesions (thorax) at the time of SRS or SRT for brain metastases (patients meeting this criterion formed the oligo-recurrence group); 3) with SRS or SRT for brain metastases, concomitant treatment for active primary lesions (thorax) with curative surgery or curative stereotactic body radiotherapy (SBRT), or curative chemoradiotherapy (sync-oligometastases group); and 4) Karnofsky performance status (KPS) ≥70...
August 19, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27535745/white-matter-lesions-reduce-number-of-brain-metastases-in-different-cancers-a-high-resolution-mri-study
#14
Benjamin-Andreas Berk, Sandra Nagel, K Hering, S Paschke, Karl-Titus Hoffmann, Rolf-Dieter Kortmann, Chiara Gaudino, Clemens Seidel
Brain metastases are major complications of common cancers. Tumor type and proneness to the CNS are thought to define the number and size of brain metastases. It is not known if intrinsic vascular factors can also have an effect. Restricted perfusion due to cerebral small vessel disease is frequent in elderly patients and causes white matter lesions (WML). The aim of this analysis was to evaluate a possible negative effect of WML and patient age on the number and size of brain metastases (BM) of different tumor entities...
August 17, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27393516/intracranial-response-to-nivolumab-in-nsclc-patients-with-untreated-or-progressing-cns-metastases
#15
Elizabeth Dudnik, Shlomit Yust-Katz, Hovav Nechushtan, Daniel A Goldstein, Alona Zer, Dov Flex, Tali Siegal, Nir Peled
Central nervous system (CNS) metastases occur in 30% of patients with advanced non-small cell lung cancer (NSCLC). Localized treatments targeting CNS metastases result in delays in systemic therapy administration and are associated with neurocognitive impairment. Nivolumab is an immune check-point inhibitor that is approved as a second-line treatment of NSCLC. Data regarding the intracranial activity of nivolumab is lacking. We retrospectively reviewed the efficacy and safety of nivolumab in five patients with advanced NSCLC and new/progressing intracranial metastases...
August 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27347208/isolated-brain-metastasis-as-a-late-recurrence-of-completely-resected-non-small-cell-lung-cancer
#16
Lixia Ju, Mingquan Han
The brain is one of the most common sites for non-small cell lung cancer (NSCLC) metastasis; however, late isolated brain metastasis as a recurrence of NSCLC is rare. The present study describes a case of isolated solitary brain metastasis as a late recurrence of NSCLC, which occurred >2 years following the successful resection of the primary tumor, and was identified by magnetic resonance imaging. To the best of our knowledge, this is the first report of isolated brain metastasis as a postoperative recurrence of NSCLC...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27226944/prognostic-value-of-mr-imaging-texture-analysis-in-brain-non-small-cell-lung-cancer-oligo-metastases-undergoing-stereotactic-irradiation
#17
Valerio Nardone, Paolo Tini, Michelangelo Biondi, Lucio Sebaste, Eleonora Vanzi, Gianmarco De Otto, Giovanni Rubino, Tommaso Carfagno, Giuseppe Battaglia, Pierpaolo Pastina, Alfonso Cerase, Lorenzo Nicola Mazzoni, Fabrizio Banci Buonamici, Luigi Pirtoli
UNLABELLED: BACKGROUND : Stereotactic irradiation is widely used in brain oligo-metastases treatment. The aim of this study is to evaluate the prognostic value of magnetic resonance imaging (MRI) texture analysis (TA) of brain metastases (BM) of non-small cell lung cancer (NSCLC). MATERIALS AND METHODS : This study included thirty-eight consecutive patients undergoing stereotactic irradiation, that is, stereotactic fractionated radiotherapy (SRT) or radiosurgery (SRS), from January 2011 to December 2014 for 1-2 brain BM from NSCLC...
2016: Curēus
https://www.readbyqxmd.com/read/27133760/apparent-diffusion-coefficient-adc-change-on-repeated-diffusion-weighted-magnetic-resonance-imaging-during-radiochemotherapy-for-non-small-cell-lung-cancer-a-pilot-study
#18
Elisabeth Weiss, John C Ford, Kathryn M Olsen, Kishor Karki, Siddharth Saraiya, Robert Groves, Geoffrey D Hugo
OBJECTIVES: Serial diffusion-weighted magnetic resonance imaging (DW-MRI) during radiochemotherapy of non-small cell lung cancer (NSCLC) is analyzed to investigate the apparent diffusion coefficient (ADC) as a potential biomarker for tumor response. METHODS: Ten patients underwent DW-MRI prior to and at three and six weeks during radiochemotherapy. Three methods of contouring primary tumors (PT) were performed to evaluate the impact of tumor heterogeneity on ADC values: PTT: whole tumor volume; PTT-N: PTT-necrosis; PTL: small volume of presumed active tumor with low ADC value...
June 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27110732/the-diagnostic-value-of-mr-imaging-in-determining-the-lymph-node-status-of-patients-with-non-small-cell-lung-cancer-a-meta-analysis
#19
Jurgen Peerlings, Esther G C Troost, Patricia J Nelemans, David C P Cobben, Johannes C J de Boer, Aswin L Hoffmann, Regina G H Beets-Tan
Purpose To summarize existing evidence of thoracic magnetic resonance (MR) imaging in determining the nodal status of non-small cell lung cancer (NSCLC) with the aim of elucidating its diagnostic value on a per-patient basis (eg, in treatment decision making) and a per-node basis (eg, in target volume delineation for radiation therapy), with results of cytologic and/or histologic examination as the reference standard. Materials and Methods A systematic literature search for original diagnostic studies was performed in PubMed, Web of Science, Embase, and MEDLINE...
October 2016: Radiology
https://www.readbyqxmd.com/read/27072258/epidermal-growth-factor-receptor-mutations-and-brain-metastasis-in-patients-with-nonadenocarcinoma-of-the-lung
#20
Dong-Yeop Shin, Dae Ho Lee, Cheol Hyeon Kim, Jae Soo Koh, Jae Cheol Lee, Hee Jong Baek, Sang-We Kim, Chang-Min Choi, Im Il Na
OBJECTIVE: This study explored the potential association between epidermal growth.factor receptor. (EGFR) mutation status and brain metastasis in patients with nonadenocarcinoma nonsmall cell lung cancer. (NSCLC). PATIENTS AND METHODS: We analyzed clinical data from 286 patients with nonadenocarcinoma NSCLC, who were tested for EGFR mutations and underwent brain magnetic resonance imaging at diagnosis. We examined the relationship between EGFR mutation and brain metastasis at initial presentation...
January 2016: Journal of Cancer Research and Therapeutics
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