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https://www.readbyqxmd.com/read/27891213/uk-guidelines-for-the-management-of-soft-tissue-sarcomas
#1
REVIEW
Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan, Ian Judson
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the limitations of the data available. However, this makes it more important that STS are managed by teams, expert in such cases, to ensure consistent and optimal treatment, as well as recruitment to clinical trials, and the ongoing accumulation of further data and knowledge...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27849967/326-characterizing-cardiac-arrest-in-pediatric-cardiac-surgery-using-sts-chsd-and-utstein-guidelines
#2
Punkaj Gupta, Andrew Wilcox, Jeffrey Gossett, Mallikarjuna Rao Rettiganti
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27732925/echocardiographic-pulmonary-hypertension-probability-is-associated-with-clinical-outcomes-after-transcatheter-aortic-valve-implantation
#3
V J Nijenhuis, M P Huitema, V M M Vorselaars, M J Swaans, T de Kroon, J A S van der Heyden, B J W M Rensing, R Heijmen, J M Ten Berg, M C Post
AIMS: Pulmonary hypertension (PH) is associated with mortality after transcatheter aortic valve implantation (TAVI). However, diagnosis based on tricuspid regurgitant velocity (TRV) is often inaccurate and unreliable. The updated PH guidelines introduced a PH probability grading implementing additional PH signs on transthoracic echocardiography (TTE), from which we aimed to analyse its effects on clinical outcomes in patients undergoing TAVI. METHODS AND RESULTS: We included 591 consecutive patients (mean age 80...
October 6, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27687052/meta-analysis-comparing-established-risk-prediction-models-euroscore-ii-sts-score-and-acef-score-for-perioperative-mortality-during-cardiac-surgery
#4
Patrick G Sullivan, Joshua D Wallach, John P A Ioannidis
A wide variety of multivariable risk models have been developed to predict mortality in the setting of cardiac surgery; however, the relative utility of these models is unknown. This study investigated the literature related to comparisons made between established risk prediction models for perioperative mortality used in the setting of cardiac surgery. A systematic review was conducted to capture studies in cardiac surgery comparing the relative performance of at least 2 prediction models cited in recent guidelines (European System for Cardiac Operative Risk Evaluation [EuroSCORE II], Society for Thoracic Surgeons 2008 Cardiac Surgery Risk Models [STS] score, and Age, Creatinine, Ejection Fraction [ACEF] score) for the outcomes of 1-month or inhospital mortality...
August 23, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27664427/is-the-ross-procedure-a-riskier-operation-perioperative-outcome-comparison-with-mechanical-aortic-valve-replacement-in-a-propensity-matched-cohort
#5
Ismail Bouhout, Pierre-Emmanuel Noly, Aly Ghoneim, Louis-Mathieu Stevens, Raymond Cartier, Nancy Poirier, Denis Bouchard, Philippe Demers, Ismail El-Hamamsy
OBJECTIVES: The aim of this study was to compare perioperative outcomes in young adults following isolated Ross procedure versus mechanical aortic valve replacement (AVR) in a high-volume centre. METHODS: From 2007 to 2015, 337 elective isolated mechanical AVRs and 137 Ross procedures were performed in young adults (<65 years) at our centre. Using a 1:1 propensity score match analysis, 140 patients were included in the study (n = 70 in each group). Perioperative outcomes were defined using STS guidelines...
September 23, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27646968/emerging-azithromycin-resistance-among-the-neisseria-gonorrhoeae-strains-isolated-in-hungary
#6
Alexandra Brunner, Eva Nemes-Nikodem, Csaba Jeney, Dora Szabo, Marta Marschalko, Sarolta Karpati, Eszter Ostorhazi
BACKGROUND: In the 1990s, azithromycin became the drug of choice for many infectious diseases but emerging resistance to the drug has only been reported in the last decade. In the last 5 years, the National Neisseria gonorrhoeae Reference Laboratory of Hungary (NNGRLH) has also observed an increased number of N. gonorrhoeae strains resistant to azithromycin. The aim of this study was to determine the most frequent sequence types (ST) of N. gonorrhoeae related to elevated levels of azithromycin MIC (minimal inhibitory concentration)...
2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27561402/public-health-research-and-scheduled-tribes-an-ethical-lens
#8
Katia S Mohindra
In this commentary, it is argued that greater attention paid to ethical considerations related to doing Public Health Research with Scheduled Tribes (STs) should be prioritized. Given the high levels of health needs among STs as well as their high levels of deprivation, cultural oppression, and impingement on their rights, there is a need to revisit our research practices to contribute to better health and overall empowerment. Specific strategies that could be integrated into research practice are offered. The paper concludes with a call for the development of national guidelines for Public Health Research with STs...
July 2016: Indian Journal of Public Health
https://www.readbyqxmd.com/read/27502605/accreditation-for-centers-of-sarcoma-surgery
#9
Sergio Sandrucci, Annalisa Trama, Vittorio Quagliuolo, Alessandro Gronchi
Soft-tissue sarcomas (STS) are a heterogeneous group of neoplasms which may be subclassified into over 70 specific histologies and may be distributed throughout the body. Approximately one-half arises in the extremities and one-third arises in the abdomen, pelvis, and retroperitoneum. The diversity and rarity of sarcomas combined with the quite large number of affected patients are factors which underline of the importance of networking in diagnosis, therapy, and research dealing with rare cancers. The expertise of the treating center is one of the most significant factors affecting survival in STS...
August 8, 2016: Updates in Surgery
https://www.readbyqxmd.com/read/27484846/hairy-matters-mtdna-quantity-and-sequence-variation-along-and-among-human-head-hairs
#10
Stijn Desmyter, Martin Bodner, Gabriela Huber, Sophie Dognaux, Cordula Berger, Fabrice Noël, Walther Parson
Hairs from the same donor have been found to differ in mtDNA sequence within and among themselves and from other tissues, which impacts interpretation of results obtained in a forensic setting. However, little is known on the magnitude of this phenomenon and published data on systematic studies are scarce. We addressed this issue by generating mtDNA control region (CR) profiles of >450 hair fragments from 21 donors by Sanger-type sequencing (STS). To mirror forensic scenarios, we compared hair haplotypes from the same donors to each other, to the corresponding buccal swab reference haplotypes and analyzed several fragments of individual hairs...
July 25, 2016: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/27354068/comparison-of-contemporary-preoperative-risk-models-at-predicting-acute-kidney-injury-after-isolated-coronary-artery-bypass-grafting-a-retrospective-cohort-study
#11
Shao-Wei Chen, Chih-Hsiang Chang, Pei-Chun Fan, Yung-Chang Chen, Pao-Hsien Chu, Tien-Hsing Chen, Victor Chien-Chia Wu, Su-Wei Chang, Pyng-Jing Lin, Feng-Chun Tsai
OBJECTIVES: Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) is associated with short-term and long-term adverse outcomes. The European System for Cardiac Operative Risk Evaluation (EuroSCORE), EuroSCORE II, the Society of Thoracic Surgeons (STS) score and Age, Creatinine and Ejection Fraction (ACEF) score, have been widely used for predicting the operative risk of cardiac surgery. The aim of this study is to investigate the discriminant ability among current available models in predicting postoperative AKI...
2016: BMJ Open
https://www.readbyqxmd.com/read/27283169/soft-tissue-sarcoma-version-2-2016-nccn-clinical-practice-guidelines-in-oncology
#12
Margaret von Mehren, R Lor Randall, Robert S Benjamin, Sarah Boles, Marilyn M Bui, Ernest U Conrad, Kristen N Ganjoo, Suzanne George, Ricardo J Gonzalez, Martin J Heslin, John M Kane, Henry Koon, Joel Mayerson, Martin McCarter, Sean V McGarry, Christian Meyer, Richard J O'Donnell, Alberto S Pappo, I Benjamin Paz, Ivy A Petersen, John D Pfeifer, Richard F Riedel, Scott Schuetze, Karen D Schupak, Herbert S Schwartz, William D Tap, Jeffrey D Wayne, Mary Anne Bergman, Jillian Scavone
Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for Soft Tissue Sarcoma (available at NCCN.org) provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumor, desmoid tumors, and rhabdomyosarcoma...
June 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27280420/evaluation-of-an-optimal-epidemiological-typing-scheme-for-legionella-pneumophila-with-whole-genome-sequence-data-using-validation-guidelines
#13
Sophia David, Massimo Mentasti, Rediat Tewolde, Martin Aslett, Simon R Harris, Baharak Afshar, Anthony Underwood, Norman K Fry, Julian Parkhill, Timothy G Harrison
Sequence-based typing (SBT), analogous to multilocus sequence typing (MLST), is the current "gold standard" typing method for investigation of legionellosis outbreaks caused by Legionella pneumophila However, as common sequence types (STs) cause many infections, some investigations remain unresolved. In this study, various whole-genome sequencing (WGS)-based methods were evaluated according to published guidelines, including (i) a single nucleotide polymorphism (SNP)-based method, (ii) extended MLST using different numbers of genes, (iii) determination of gene presence or absence, and (iv) a kmer-based method...
August 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27265678/characterization-of-methicillin-resistant-staphylococcus-aureus-strains-among-inpatients-and-outpatients-in-a-referral-hospital-in-tehran-iran
#14
Fateh Rahimi, Leili Shokoohizadeh
Methicillin resistant Staphylococcus aureus is one of the most common causes of a variety of infections ranging from wound infections to urinary tract infections (UTI) in hospital and community. In this study during 3 years we characterized the antibiotic resistance patterns of 491 hospital acquired MRSA and community associated MRSA strains by the guidelines of clinical and laboratory standard institute. A combination of high resolution PhP typing method and SCCmec typing were used for clonal dissemination of isolates...
August 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27198004/diverse-genetic-background-of-multidrug-resistant-pseudomonas-aeruginosa-from-mainland-china-and-emergence-of-an-extensively-drug-resistant-st292-clone-in-kunming
#15
Xin Fan, Yue Wu, Meng Xiao, Zhi-Peng Xu, Timothy Kudinha, Alda Bazaj, Fanrong Kong, Ying-Chun Xu
For a better understanding of the multidrug resistant Pseudomonas aeruginosa (MDR-PA) epidemiology in mainland China, a nationwide surveillance network of 27 tertiary hospitals was established. Non-duplicate MDR-PA isolates from 254 cases of nosocomial infections, were collected during the period August 2011 to July 2012. Minimum inhibitory concentrations (MICs) of nine antimicrobial agents were determined by broth micro-dilution method according to the CLSI guidelines [M7-A10]. Genotyping analysis was performed by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27168856/the-saudi-thoracic-society-pneumococcal-vaccination-guidelines-2016
#16
N S Alharbi, A M Al-Barrak, M S Al-Moamary, M O Zeitouni, M M Idrees, M O Al-Ghobain, A A Al-Shimemeri, Mohamed S Al-Hajjaj
Streptococcus pneumoniae (pneumococcus) is the leading cause of morbidity and mortality worldwide. Saudi Arabia is a host to millions of pilgrims who travel annually from all over the world for Umrah and the Hajj pilgrimages and are at risk of developing pneumococcal pneumonia or invasive pneumococcal disease (IPD). There is also the risk of transmission of S. pneumoniae including antibiotic resistant strains between pilgrims and their potential global spread upon their return. The country also has unique challenges posed by susceptible population to IPD due to people with hemoglobinopathies, younger age groups with chronic conditions, and growing problem of antibiotic resistance...
April 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27107792/the-width-of-resection-margins-influences-local-recurrence-in-soft-tissue-sarcoma-patients
#17
V Kainhofer, M A Smolle, J Szkandera, B Liegl-Atzwanger, W Maurer-Ertl, A Gerger, J Riedl, A Leithner
BACKGROUND: Patients with soft tissue sarcoma (STS) being treated following the standardized guidelines can still not be guaranteed to remain free from local recurrence (LR). A complete tumour resection has been accepted as a major prognostic factor for LR. This retrospective study was designed to analyse the influence of two different classifications of resection margins (R-classification and UICC-classification) on LR in STS patients. MATERIALS AND METHODS: Of 411 patients treated at our institution for STS, 265 were eligible for statistical analysis...
June 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27026020/2016-acc-aha-guideline-focused-update-on-duration-of-dual-antiplatelet-therapy-in-patients-with-coronary-artery-disease-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice-guidelines-an-update-of-the-2011
#18
https://www.readbyqxmd.com/read/27021033/variation-in-pulmonary-resection-practices-between-the-society-of-thoracic-surgeons-and-the-european-society-of-thoracic-surgeons-general-thoracic-surgery-databases
#19
Christopher W Seder, Michele Salati, Benjamin D Kozower, Cameron D Wright, Pierre-Emmanuel Falcoz, Alessandro Brunelli, Felix G Fernandez
BACKGROUND: Clinical guidelines are created to reduce variation in care practices, with the goal of improving patient outcomes. There is currently no international consensus on best practices for pulmonary resection. Our aim was to evaluate variation in treatment patterns and outcomes for pulmonary resection by comparing The Society of Thoracic Surgeons (STS) and the European Society of Thoracic Surgery (ESTS) general thoracic surgery databases (GTSDs). METHODS: An international collaboration was established between the STS and ESTS GTSD task forces...
June 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27003287/oxa-carbapenemases-present-in-clinical-acinetobacter-baumannii-calcoaceticus-complex-isolates-from-patients-in-kurdistan-region-iraq
#20
Aryann R Ganjo, Delshad M Maghdid, Isam Y Mansoor, Dik J Kok, Juliette A Severin, Henri A Verbrugh, Deborah Kreft, M H Fatah, A A Alnakshabandi, Asad Dlnya, Anette M Hammerum, Kim Ng, Wil Goessens
In addition to intrinsic resistance in Acinetobacter baumannii, many different types of acquired resistance mechanisms have been reported, including the presence of VIM and IMP metallo β-lactamases and also of blaOXA-23-like and blaOXA-58-like enzymes. In the Kurdistan region of Iraq, the multiresistant A. baumannii-calcoaceticus complex is prevalent. We characterized the different mechanisms of resistance present in clinical isolates collected from different wards and different hospitals from the Kurdistan region...
December 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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