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Magnetic resonance imaging of lung cancer

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https://www.readbyqxmd.com/read/29145881/multiple-small-hemorrhagic-infarcts-in-cerebral-air-embolism-a-case-report
#1
Masaya Togo, Taku Hoshi, Ryosuke Matsuoka, Yukihiro Imai, Nobuo Kohara
BACKGROUND: Cerebral air embolism is a rare cause of cerebral infarction. In cerebral air embolism, T2 star-weighted imaging shows numerous spotty hypointense signals. Previous reports have suggested that these signals represent air in the brain and are gradually diminished and absorbed. We experienced two cases of cerebral air embolism, and in one of them, we conducted an autopsy. CASE PRESENTATION: Case 1 was a 76-year-old Japanese man with lung cancer and emphysema...
November 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29142626/resection-and-observation-for-brain-metastasis-without-prompt-postoperative-radiation-therapy
#2
Tae-Wook Song, In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Woo-Youl Jang
Objective: Total resection without consecutive postoperative whole brain radiation therapy is indicated for patients with a single or two sites of brain metastasis, with close follow-up by serial magnetic resonance imaging (MRI). In this study, we explored the effectiveness, usefulness, and safety of this follow-up regimen. Methods: From January 2006 to December 2015, a total of 109 patients (76 males, 33 females) underwent tumor resection as the first treatment for brain metastases (97 patients with single metastases, 12 with two metastases)...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29137032/non-hodgkin-lymphoma-of-multiple-extranodal-involvement-seen-on-mri-fdg-pet-ct-scans-a-case-report
#3
Shan Wang, Meng Meng, Qiuhu Wang, Kai Xu
RATIONALE: Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma (NHL). The most common extranodal sites of ALCL are skin, subcutaneous tissue, bone, lung, and gastrointestinal organs. This study reports a case of ALCL with multiple extranodal involvement, especially the whole body skeletal muscles, with the aim to share the imaging features of the ALCL including magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125923/prophylactic-cranial-irradiation-for-extensive-small-cell-lung-cancer
#4
Steven E Schild, Terence T Sio, Thomas B Daniels, Stephen G Chun, Dirk Rades
Small-cell lung cancer (SCLC) has a high predilection for metastasizing to the brain after chemotherapy. This has been blamed on the blood-brain barrier, which prevents chemotherapy from penetrating into the brain, thus creating a sanctuary site. It has been estimated that up to three quarters of patients with SCLC will eventually develop brain metastases. This led investigators to administer prophylactic cranial irradiation (PCI) to decrease this risk. Several trials were performed in patients with SCLC after initial therapy (chemotherapy with or without thoracic radiotherapy) that compared the outcomes of PCI versus no PCI...
November 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29123008/reproducibility-of-mr-based-attenuation-maps-in-pet-mri-and-the-impact-on-pet-quantification-in-lung-cancer
#5
Anders Olin, Claes N Ladefoged, Natasha H Langer, Sune H Keller, Johan O Löfgren, Adam E Hansen, Andreas Kjær, Seppo W Langer, Barbara M Fischer, Flemming L Andersen
AIM: Quantitative positron emission tomography/magnetic resonance imaging (PET/MRI) is dependent upon reliable and reproducible MR-based attenuation correction (MR-AC). In this study we evaluated the quality of current vendor-provided thoracic MR-AC maps, and further investigated the reproducibility of these in terms of their impact on fluorodeoxyglucose (FDG)-PET quantification in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Eleven patients with inoperable NSCLC underwent two to five thoracic PET/MRI scan-rescan examinations within 22 days...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29114603/audiovisual-biofeedback-guided-breath-hold-improves-lung-tumor-position-reproducibility-and-volume-consistency
#6
Danny Lee, Peter B Greer, Carminia Lapuz, Joanna Ludbrook, Perry Hunter, Jameen Arm, Sean Pollock, Kuldeep Makhija, Ricky T O'Brien, Taeho Kim, Paul Keall
Purpose: Respiratory variation can increase the variability of tumor position and volume, accounting for larger treatment margins and longer treatment times. Audiovisual biofeedback as a breath-hold technique could be used to improve the reproducibility of lung tumor positions at inhalation and exhalation for the radiation therapy of mobile lung tumors. This study aimed to assess the impact of audiovisual biofeedback breath-hold (AVBH) on interfraction lung tumor position reproducibility and volume consistency for respiratory-gated lung cancer radiation therapy...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29108860/fibrosis-imaging-current-concepts-and-future-directions
#7
Maike Baues, Anshuman Dasgupta, Josef Ehling, Jai Prakash, Peter Boor, Frank Tacke, Fabian Kiessling, Twan Lammers
Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suffer from several drawbacks, including their invasive nature, sampling variability and limited spatial information. To overcome these limitations, multiple different imaging tools and technologies have been evaluated over the years, including x-ray imaging, computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
November 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29098882/ph-and-thermo-sensitive-mtx-loaded-magnetic-nanocomposites-synthesis-characterization-and-in-vitro-studies-on-a549-lung-cancer-cell-and-mr-imaging
#8
Masoud Farshbaf, Roya Salehi, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Soodabeh Davaran
In current study we proposed a facile method for fabrication of multifunctional pH- and thermo sensitive magnetic nanocamposites (MNCs) as a theranostic agent employing in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29094453/uterine-metastasis-of-lung-adenocarcinoma-under-molecular-target-therapy-with-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-a-case-report-and-review-of-the-literature
#9
Mayu Shibata, Masato Shizu, Kazuko Watanabe, Akihiro Takeda
A 63-year-old woman presented with abnormal vaginal bleeding. Her disease history was significant, and included advanced lung adenocarcinoma with a deletion mutation in exon 19 of the epidermal growth factor receptor (EGFR) gene, which was managed by concurrent chemoradiotherapy, followed by molecular targeted therapy with tyrosine kinase inhibitors (TKIs) for a two-year period. Contrast-enhanced computed tomography showed the enlargement of a previously suspicious myoma node, with peripheral enhancement. Hemorrhagic necrosis was also observed on magnetic resonance imaging...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29077861/the-role-of-prophylactic-cranial-irradiation-for-patients-with-small-cell-lung-cancer
#10
Yoshiro Nakahara, Jiichiro Sasaki, Tomoya Fukui, Sakiko Otani, Satoshi Igawa, Kazushige Hayakawa, Noriyuki Masuda
Small-cell lung cancer (SCLC) has a particular propensity to metastasize to the brain, affecting ~10% of SCLC patients at diagnosis, but may occur in more than 50% of 2-year survivors. Most cytotoxic drugs have limited ability to cross the blood-brain barrier, and the effectiveness of chemotherapy for brain metastasis is limited. Therefore, prophylactic cranial irradiation (PCI) has been proposed to treat SCLC. A meta-analysis revealed that PCI significantly decreased the risk of brain metastasis and increased the 3-year survival rate; it has been established as a standard therapy for limited-disease SCLC...
October 25, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29070999/treatment-of-leptomeningeal-metastases-in-a-patient-with-non-small-cell-lung-cancer-harboring-egfr-t790m-mutation
#11
Hardy Niu, Junle Zhou, Harvinder Maan, Maurie Markman, Jiaxin Niu
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be more frequent in lung cancer patients with EGFR mutations, posing a unique clinical challenge to treating physicians. CASE PRESENTATION: We report the case of a 68-year-old Asian man with metastatic lung adenocarcinoma harboring an EGFR L858R mutation, which was initially treated with gefitinib. He developed disease progression 1 year later...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29069871/leptomeningeal-disease-current-diagnostic-and-therapeutic-strategies
#12
REVIEW
Gautam Nayar, Tiffany Ejikeme, Pakawat Chongsathidkiet, Aladine A Elsamadicy, Kimberly L Blackwell, Jeffrey M Clarke, Shivanand P Lad, Peter E Fecci
Leptomeningeal disease has become increasingly prevalent as novel therapeutic interventions extend the survival of cancer patients. Although a majority of leptomeningeal spread occurs secondary to breast cancer, lung cancer, and melanoma, a wide variety of malignancies have been reported as primary sources. Symptoms on presentation are equally diverse, often involving a combination of neurological deficits with the possibility of obstructive hydrocephalus. Diagnosis is definitively made via cerebrospinal fluid cytology for malignant cells, but neuro-imaging with high quality T1-weighted magnetic resonance imaging can aid diagnosis and localization...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29066121/patterns-of-intraosseous-recurrence-after-stereotactic-body-radiation-therapy-for-coxal-bone-metastasis
#13
Kei Ito, Takuya Shimizuguchi, Keiji Nihei, Tomohisa Furuya, Hiroaki Ogawa, Hiroshi Tanaka, Keisuke Sasai, Katsuyuki Karasawa
PURPOSE: To analyze the detailed pattern of intraosseous failure after stereotactic body radiation therapy (SBRT) for coxal bone metastasis. METHODS AND MATERIALS: Patients treated with SBRT to coxal bone metastasis were identified by retrospective chart review. The SBRT doses were 30 Gy or 35 Gy in 5 fractions. A margin of 5 to 10 mm was added to the gross tumor volume to create the clinical target volume. We evaluated the presence or absence of intraosseous recurrence using magnetic resonance imaging...
September 5, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29065541/screening-and-biosensor-based-approaches-for-lung-cancer-detection
#14
REVIEW
Lulu Wang
Early diagnosis of lung cancer helps to reduce the cancer death rate significantly. Over the years, investigators worldwide have extensively investigated many screening modalities for lung cancer detection, including computerized tomography, chest X-ray, positron emission tomography, sputum cytology, magnetic resonance imaging and biopsy. However, these techniques are not suitable for patients with other pathologies. Developing a rapid and sensitive technique for early diagnosis of lung cancer is urgently needed...
October 23, 2017: Sensors
https://www.readbyqxmd.com/read/29064573/effects-of-magnetic-field-orientation-and-strength-on-the-treatment-planning-of-non-small-cell-lung-cancer
#15
Schrenk Oliver, Spindeldreier Claudia Katharina, Burigo Lucas Norberto, Hoerner-Rieber Juliane, Pfaffenberger Asja
PURPOSE: Magnetic resonance image-guided radiotherapy (MRgRT) has the potential to increase the accuracy of radiation treatment delivery. Several research groups have developed hybrid MRgRT devices differing by radiation source used, magnetic field orientation and strength. In this work, we investigate the impact of different magnetic field orientations and strengths on the treatment planning of non-small cell lung cancer patients (NSCLC). METHODS: A framework using the in-house developed treatment planning system matRad and the EGSnrc Monte Carlo code system was introduced to perform Monte Carlo based treatment planning in the presence of a magnetic field...
October 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/29059917/a-radiomics-evaluation-of-2d-and-3d-mri-texture-features-to-classify-brain-metastases-from-lung-cancer-and-melanoma
#16
Rafael Ortiz-Ramon, Andres Larroza, Estanislao Arana, David Moratal
Brain metastases are occasionally detected before diagnosing their primary site of origin. In these cases, simple visual examination of medical images of the metastases is not enough to identify the primary cancer, so an extensive evaluation is needed. To avoid this procedure, a radiomics approach on magnetic resonance (MR) images of the metastatic lesions is proposed to classify two of the most frequent origins (lung cancer and melanoma). In this study, 50 T1-weighted MR images of brain metastases from 30 patients were analyzed: 27 of lung cancer and 23 of melanoma origin...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29038405/-our-experiences-of-vertebrectomy-for-lung-cancer-invading-the-spine
#17
Soichi Oka, Fumihiro Tanaka
BACKGROUND: Surgery for lung cancer invading the spine remains challenging associated with high morbidity and mortality. We describe our surgical approach and assess the outcome of surgical treatment lung cancer invading the spine. METHODS: We retrospectively reviewed our recent experiences of lung cancer with vertebral invasion, in which we have performed total or partial vertebrectomy from 2011 through 2015. RESULTS: We experienced 8 patients who were treated with partial or total vertebrectomy for lung cancer...
October 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29029832/tumour-auto-contouring-on-2d-cine-mri-for-locally-advanced-lung-cancer-a-comparative-study
#18
Martin F Fast, Björn Eiben, Martin J Menten, Andreas Wetscherek, David J Hawkes, Jamie R McClelland, Uwe Oelfke
BACKGROUND AND PURPOSE: Radiotherapy guidance based on magnetic resonance imaging (MRI) is currently becoming a clinical reality. Fast 2d cine MRI sequences are expected to increase the precision of radiation delivery by facilitating tumour delineation during treatment. This study compares four auto-contouring algorithms for the task of delineating the primary tumour in six locally advanced (LA) lung cancer patients. MATERIAL AND METHODS: Twenty-two cine MRI sequences were acquired using either a balanced steady-state free precession or a spoiled gradient echo imaging technique...
October 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#19
REVIEW
T A Szyszko, G J R Cook
Combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
October 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29027063/inflammatory-myofibroblastic-tumors-of-the-breast-with-simultaneous-intracranial-lung-and-pancreas-involvement-ultrasonographic-findings-and-a-review-of-the-literature
#20
Mari Inoue, Tomoyuki Ohta, Hisashi Shioya, Shun Sato, Hiroyuki Takahashi, Norio Nakata, Chiaki Taniguchi, Megumi Hirano, Makiko Nishioka, Hironori Yamakawa
We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. Here, we present the clinical imaging results and report the significance of sonographic findings of breast IMT along with a review of the literature. A 16-year-old girl with a history of subarachnoidal hemorrhage was admitted to our hospital due to tonic-clonic seizure. Computed tomography (CT) and magnetic resonance imaging (MRI) showed multiple intracranial, lung, and pancreas mass lesions and a solitary mass lesion in the right breast...
October 12, 2017: Journal of Medical Ultrasonics
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