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https://www.readbyqxmd.com/read/28723866/a-case-of-resistance-to-tyrosine-kinase-inhibitor-therapy-small-cell-carcinoma-transformation-concomitant-with-plasma-genotyped-t790m-positivity
#1
Yanjun Xu, Zhiyu Huang, Lei Gong, Yun Fan
Although non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations are responsive to EGFR-tyrosine kinase inhibitors, drug resistances are always inevitable. The secondary somatic EGFR threonine-methionine substitution at position 790 (T790M) mutation accounts for ∼50% of acquired resistance mechanisms. Small cell lung cancer (SCLC) transformation is a relatively rare mechanism, but has recently attracted considerable attention. The coexistence of both the mechanisms in one patient is much more scarce in clinic...
July 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28722201/susceptibility-induced-distortion-correction-in-hyperpolarized-echo-planar-imaging
#2
Jack J Miller, Angus Z Lau, Damian J Tyler
PURPOSE: Echo planar imaging is an attractive rapid imaging readout that can image hyperpolarized compounds in vivo. By alternating the sign of the phase encoding gradient waveform, spatial offsets arising from uncertain frequency shifts can be determined. We show here that blip-reversed echo planar imaging can also be used to correct for susceptibility and B0 inhomogeneity effects that would otherwise produce image-domain distortion in the heart. METHODS: Previously acquired blip-reversed cardiac 3D-Spectral-Spatial echo planar imaging volumetric timecourses of hyperpolarized [1-(13) C]pyruvate were distortion corrected by a deformation field estimated by reconstructing signal-to-noise ratio (SNR)-weighted progressively subsampled temporally summed images of each metabolite...
July 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28722166/choir-singing-and-creative-writing-enhance-emotion-regulation-in-adults-with-chronic-mental-health-conditions
#3
Genevieve A Dingle, Elyse Williams, Jolanda Jetten, Jonathon Welch
OBJECTIVES: Adults with mental health conditions commonly experience difficulties with emotion regulation which affect their social functioning. Arts-based groups provide opportunities for shared emotional experiences and emotion regulation. This study explores emotion regulation strategies and the emotional effects of arts-based group participation in adults with mental health problems and in controls. DESIGN AND METHOD: The 62 participants included 39 adults with chronic mental health problems who were members of arts-based groups (ABG) and 23 comparison choir (CC) members who were not specifically experiencing mental health problems...
July 18, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28720227/co-creative-development-of-an-ehealth-nursing-intervention-self-management-support-for-outpatients-with-cancer-pain
#4
Laura M J Hochstenbach, Annemie M Courtens, Sandra M G Zwakhalen, Joan Vermeulen, Maarten van Kleef, Luc P de Witte
INTRODUCTION: Co-creative methods, having an iterative character and including different perspectives, allow for the development of complex nursing interventions. Information about the development process is essential in providing justification for the ultimate intervention and crucial in interpreting the outcomes of subsequent evaluations. This paper describes a co-creative method directed towards the development of an eHealth intervention delivered by registered nurses to support self-management in outpatients with cancer pain...
August 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28719422/polarity-independent-effects-of-transcranial-direct-current-stimulation-over-the-bilateral-opercular-somatosensory-region-a-magnetoencephalography-study
#5
Kei Nakagawa, Soichiro Koyama, Koji Inui, Satoshi Tanaka, Ryusuke Kakigi, Norihiro Sadato
The opercular somatosensory region (OP) plays an indispensable role in pain perception. In the present study, we investigated the neurophysiological effects of transcranial direct current stimulation (tDCS) over the OP. Somatosensory-evoked magnetic fields following noxious intraepidermal electrical stimulation to the left index finger (pain-SEFs) were recorded before and after tDCS with a single-blind, sham-controlled, cross-over trial design. Three tDCS conditions of left anodal/right cathodal tDCS, left cathodal/right anodal tDCS (each, 2 mA, 12 min), and sham tDCS (2 mA, 15 s) were applied...
July 17, 2017: Neuroreport
https://www.readbyqxmd.com/read/28719381/detection-of-putative-stem-cell-markers-in-invasive-ductal-carcinoma-of-the-breast-by-immunohistochemistry-does-it-improve-prognostic-predictive-assessments
#6
Rodrigo V Oliveira, Valéria B Souza, Philipi C Souza, Fernando A Soares, José Vassallo, Rafael M Rocha, André A Schenka
INTRODUCTION: Experimental evidences from the last 2 decades supports the existence of a special type of neoplastic cell with stem-like features [cancer stem cell (CSC)] and their role in the pathophysiology and therapeutic resistance of breast cancer. However, their clinical value in human breast cancer has not been fully determined. MATERIALS AND METHODS: An immunohistochemistry panel of 10 putative CSC markers (CD34, C-KIT, CD10, SOX-2, OCT 3/4, p63, CD24, CD44, CD133, and ESA/EPCAM) was applied to 74 cases of breast cancer, followed in a Regional Cancer Center of Minas Gerais State, Brazil, from 2004 to 2006...
July 17, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28719380/comparison-of-different-antibody-clones-for-immunohistochemistry-detection-of-programmed-cell-death-ligand-1-pd-l1-on-non-small-cell-lung-carcinoma
#7
Edwin R Parra, Pamela Villalobos, Barbara Mino, Jaime Rodriguez-Canales
Programmed cell death ligand 1 (PD-L1) is a major immune checkpoint protein that mediates antitumor immune suppression and response. Preliminary data suggest that its detection using immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded tissues may predict clinical response to PD-1/PD-L1 therapy. In diagnostic pathology, it is essential to count with a validated IHC that can reliably detect PD-L1-positive cases. The present study was conducted to compare and validate different PD-L1 commercial clones and identify which ones can be reliably used by surgical pathologist to detect PD-L1 expression in human cancer tissues...
July 17, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28719285/trial-of-a-novel-intervention-to-improve-multiple-food-hygiene-behaviors-in-nepal
#8
Om Prasad Gautam, Wolf-Peter Schmidt, Sandy Cairncross, Sue Cavill, Valerie Curtis
AbstractIn this study, we report on the results of a trial of an intervention to improve five food hygiene behaviors among mothers of young children in rural Nepal. This novel intervention targeted five behaviors; cleanliness of serving utensils, handwashing with soap before feeding, proper storage of cooked food, and thorough reheating and water treatment. Based on formative research and a creative process using the Behavior-Centered Design approach, an innovative intervention package was designed and delivered over a period of 3 months...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28715795/recycling-and-social-technologies-for-sustainability-the-brazilian-experience-of%C3%A2-wastepickers-inclusion-in-selective-collection-programs
#9
Francisco de Paula Antunes Lima, Fabiana Goulart de Oliveira
BACKGROUND: Alternatives are being developed for waste treatment all over the world. Solidary selective collection is a recognized social technology for taking millions of people out of absolute poverty. However, this technology raises crucial questions regarding its nature and development perspective. What can be said of the legitimacy of a social technology that is born from misery and maintains wastepickers in precarious work conditions? OBJECTIVE: This article approaches issues based on the analysis of the wastepickers' work process, highlighting the difficulties and interpersonal conflicts, the strong social bonds and creativity that reveal the potential of efficiency and solidarity of this social technology...
July 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28715359/attempting-to-validate-the-over-under-triage-matrix-at-a-level-i-trauma-center
#10
James W Davis, Rachel C Dirks, Lawrence P Sue, Krista L Kaups
BACKGROUND: The Optimal Resources Document (ORD) mandates trauma activation based on injury mechanism, physiologic and anatomic criteria and recommends using the over/undertriage matrix (Matrix) to evaluate the appropriateness of trauma team activation. The purpose of this study was to assess the effectiveness of the Matrix method by comparing patients appropriately triaged with those undertriaged. We hypothesized that these two groups are different and Matrix does not discriminate the needs or outcomes of these different groups of patients...
July 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28713586/formal-thought-disorder-in-people-at-ultra-high-risk-of-psychosis
#11
Arsime Demjaha, Sara Weinstein, Daniel Stahl, Fern Day, Lucia Valmaggia, Grazia Rutigliano, Andrea De Micheli, Paolo Fusar-Poli, Philip McGuire
BACKGROUND: Formal thought disorder is a cardinal feature of psychosis. However, the extent to which formal thought disorder is evident in ultra-high-risk individuals and whether it is linked to the progression to psychosis remains unclear. AIMS: Examine the severity of formal thought disorder in ultra-high-risk participants and its association with future psychosis. METHOD: The Thought and Language Index (TLI) was used to assess 24 ultra-high-risk participants, 16 people with first-episode psychosis and 13 healthy controls...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28713585/associations-of-centrally-acting-ace-inhibitors-with-cognitive-decline-and-survival-in-alzheimer-s-disease
#12
Karim Fazal, Gayan Perera, Mizanur Khondoker, Robert Howard, Robert Stewart
BACKGROUND: Cognitive improvement has been reported in patients receiving centrally acting angiotensin-converting enzyme inhibitors (C-ACEIs). AIMS: To compare cognitive decline and survival after diagnosis of Alzheimer's disease between people receiving C-ACEIs, non-centrally acting angiotensin-converting enzyme inhibitors (NC-ACEIs), and neither. METHOD: Routine Mini-Mental State Examination (MMSE) scores were extracted in 5260 patients receiving acetylcholinesterase inhibitors and analysed against C-/NC-ACEI exposure at the time of Alzheimer's disease diagnosis...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28713301/understanding-the-impact-of-expertise-in-joint-and-solo-improvisation
#13
Johann Issartel, Mathieu Gueugnon, Ludovic Marin
Joint-improvisation is not only an open-ended creative action that two or more people perform together in the context of an artistic performance (e.g., theatre, music or dance). Joint-improvisation also takes place in daily life activities when humans take part in collective performance such as toddlers at play or adults engaged in a conversation. In the context of this article, joint-improvisation has been looked at from a social motor coordination perspective. In the literature, the nature of the social motor coordination characteristics of joint-improvisation for either the creative aspect or daily life features of this motor performance remains unclear...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28713168/creative-destruction-and-subjective-well-being
#14
Philippe Aghion, Ufuk Akcigit, Angus Deaton, Alexandra Roulet
In this paper we analyze the relationship between turnover-driven growth and subjective wellbeing. Our model of innovation-led growth and unemployment predicts that: (i) the effect of creative destruction on expected individual welfare should be unambiguously positive if we control for unemployment, less so if we do not; (ii) job creation has a positive and job destruction has a negative impact on wellbeing; (iii) job destruction has a less negative impact in US Metropolitan Statistical Areas (MSA) within states with more generous unemployment insurance policies; (iv) job creation has a more positive effect on individuals that are more forward-looking...
December 2016: American Economic Review
https://www.readbyqxmd.com/read/28713128/introduction-community-academic-partnerships-in-research-and-public-health
#15
Emily E Anderson, Kevin J Valadares
This symposium includes twelve personal narratives from individuals and teams who have been engaged in community-academic partnerships in research and public health. This issue also includes four commentaries on these narratives by experts in patient and research subject advocacy, healthcare and biomedical ethics, social science, and health education funding. While much has been written about community-academic partnerships, what appears in the literature does not include in-depth, personal reflection on the challenges and obstacles faced in these partnerships...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/28713099/-giving-medico-legal-opinions-in-cases-with-suspicion-of-medical-mistake-part-1-between-medicine-and-justice
#16
Czesław Chowaniec, Małgorzata Chowaniec, Mateusz Wilk
Creating medico-legal opinion is a sophisticated investigative, analytical, decision-making and creative process. Forensic medicine specialist in cooperation with clinical medicine consultants, on the basis of evidence analysis, which was gathered during procedures and contained in the acts has to create an objective and essential opinion. This opinion is a vital, very important and irreplaceable proof in every case. Judicial body consults with forensic medicine specialist or specialists if there are circumstances for settlement of which there is a need of classified informations - art...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712612/patient-reported-outcome-and-observer-reported-outcome-assessment-in-rare-disease-clinical-trials-an-ispor-coa-emerging-good-practices-task-force-report
#17
Katy Benjamin, Margaret K Vernon, Donald L Patrick, Eleanor Perfetto, Sandra Nestler-Parr, Laurie Burke
BACKGROUND: Rare diseases (RDs) affect a small number of people within a population. About 5000 to 8000 distinct RDs have been identified, with an estimated 6% to 8% of people worldwide suffering from an RD. Approximately 75% of RDs affect children. Frequently, these conditions are heterogeneous; many are progressive. Regulatory incentives have increased orphan drug designations and approvals. OBJECTIVE: To develop emerging good practices for RD outcomes research addressing the challenges inherent in identifying, selecting, developing, adapting, and implementing patient-reported outcome (PRO) and observer-reported outcome (ObsRO) assessments for use in RD clinical trials...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28712538/lessons-from-the-lives-of-celebrated-musicians-what-armstrong-cash-dylan-ellington-fitzgerald-and-sinatra-can-teach-us-about-creative-resilience-and-aging
#18
Jeffrey M Lyness
For a decade the author has delivered presentations using techniques from the humanities, principally biography, to elucidate themes of creative resilience and aging in the lives of well-known musicians, illustrated with excerpted images, audio clips, and videos. The goal has been to stimulate discussions about the potential for creative growth in later years, even in the face of the professional and personal setbacks inevitable in the course of life, with implications for clinical work with older adults and for ourselves as we age...
June 15, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28710925/an-exploratory-assessment-of-weight-loss-videos-on-youtube%C3%A2
#19
C H Basch, I C-H Fung, A Menafro, C Mo, J Yin
OBJECTIVE: To describe the variation in contents between different video sources on YouTube™ regarding weight loss. STUDY DESIGN: The 100 most widely viewed weight loss videos on YouTube™ were selected for manual coding. METHODS: Videos were manually coded based on sources and contents, we also identify themes for each of the videos. Univariate logistic regression was used to assess difference in contents between videos from different sources...
July 12, 2017: Public Health
https://www.readbyqxmd.com/read/28708817/innovating-cystic-fibrosis-clinical-trial-designs-in-an-era-of-successful-standard-of-care-therapies
#20
Donald R VanDevanter, Nicole Mayer-Hamblett
PURPOSE OF REVIEW: Evolving cystic fibrosis 'standards of care' have influenced recent cystic fibrosis clinical trial designs for new therapies; care additions/improvements will require innovative trial designs to maximize feasibility and efficacy detection. RECENT FINDINGS: Three cystic fibrosis therapeutic areas (pulmonary exacerbations, Pseudomonas aeruginosa airway infections, and reduced cystic fibrosis transmembrane conductance regulator [CFTR] protein function) differ with respect to the duration for which recognized 'standards of care' have been available...
July 13, 2017: Current Opinion in Pulmonary Medicine
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