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https://www.readbyqxmd.com/read/28107288/effects-of-infant-formula-with-human-milk-oligosaccharides-on-growth-and-morbidity-a-randomized-multicenter-trial
#1
Giuseppe Puccio, Philippe Alliet, Cinzia Cajozzo, Elke Janssens, Giovanni Corsello, Norbert Sprenger, Susan Wernimont, Delphine Egli, Laura Gosoniu, Philippe Steenhout
OBJECTIVES: We evaluated effects of infant formula supplemented with 2 human milk oligosaccharides (HMOs) on infant growth, tolerance and morbidity. METHODS: Healthy infants, 0-14 days old, were randomized to an intact-protein, cow's-milk-based infant formula (Control, n = 87) or the same formula with 1.0 g/L 2'fucosyllactose (2'FL) and 0.5 g/L lacto-N-neotetraose (LNnT) (Test, n = 88) from enrollment to 6 months; all infants received standard follow-up formula without HMOs from 6-12 months...
January 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28107274/the-sluscore-a-novel-method-for-detecting-hazardous-hypotension-in-adult-patients-undergoing-noncardiac-surgical-procedures
#2
Wolf H Stapelfeldt, Hui Yuan, Jefferson K Dryden, Kristen E Strehl, Jacek B Cywinski, Jesse M Ehrenfeld, Pamela Bromley
BACKGROUND: It has been suggested that longer-term postsurgical outcome may be adversely affected by less than severe hypotension under anesthesia. However, evidence-based guidelines are unavailable. The present study was designed to develop a method for identifying patients at increased risk of death within 30 days in association with the severity and duration of intraoperative hypotension. METHODS: Intraoperative mean arterial blood pressure recordings of 152,445 adult patients undergoing noncardiac surgery were analyzed for periods of time accumulated below each one of the 31 thresholds between 75 and 45 mm Hg (hypotensive exposure times)...
January 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28107257/perceived-stress-as-a-risk-factor-for-dyspepsia-a-register-based-cohort-study
#3
Ulrik Deding, Christian Torp-Pedersen, Henrik Bøggild
OBJECTIVE: Dyspepsia is a common condition and has a huge impact on quality of life and working capacity, but its causes are not well understood. An association between stress and dyspepsia has been debated for decades, but the issue has not been resolved. We examined the 3-year risk of redeeming a proton-pump inhibitor or an H2-receptor antagonist as a proxy of dyspepsia according to the level of perceived stress. PARTICIPANTS AND METHODS: Perceived stress was measured in a general health survey of 16 124 Danes aged older than 16 years of age in 2010 using Cohen's Perceived Stress Scale...
January 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28107251/internet-delivered-self-management-support-for-improving-coronary-heart-disease-and-self-management-related-outcomes-a-systematic-review
#4
Jorge Palacios, Geraldine A Lee, Maria Duaso, Abigail Clifton, Ian J Norman, Derek Richards, Elizabeth Alexandra Barley
INTRODUCTION: Coronary heart disease (CHD) is associated with significant morbidity and mortality, including mental health comorbidity, which is associated with poor outcomes. Self-management is key, but there is limited access to self-management support. Internet-delivered interventions may increase access. OBJECTIVE: The aim of this study was to conduct a systematic review to (1) determine the effectiveness of Internet-delivered CHD self-management support for improving CHD, mood, and self-management related outcomes and (2) identify and describe essential components for effectiveness...
January 20, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28107227/structural-level-differences-in-the-mother-to-child-hiv-transmission-rate-in-south-africa-a-multilevel-assessment-of-individual-health-facility-and-provincial-level-predictors-of-infant-hiv-transmission
#5
S Woldesenbet, D J Jackson, C J Lombard, T H Dinh, V Ramokolo, T Doherty, G G Sherman, Y Pillay, A E Goga
OBJECTIVES: In 2010, South Africa reported an early mother to child transmission (MTCT) rate of 3.5% at 4-8 weeks postpartum. Provincial early MTCT rates ranged from 1.4% (95% confidence interval [CI]: 0.1-3.4%) to 5.9% (95% CI: 3.8-8.0%). We sought to determine reasons for these geographic differences in MTCT rates. METHODS: This study employed multilevel modelling using 2010 South African PMTCT evaluation (SAPMTCTE) data from 530 facilities. Interview data and infant blood samples were collected from 3085 mother-infant pairs at 4-8 weeks postpartum...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28107222/romidepsin-induced-hiv-1-viremia-during-effective-art-contains-identical-viral-sequences-with-few-deleterious-mutations
#6
Anni Winckelmann, Kirston Barton, Bonnie Hiener, Timothy E Schlub, Wei Shao, Thomas A Rasmussen, Lars Østergaard, Ole S Søgaard, Martin Tolstrup, Sarah Palmer
OBJECTIVE: To investigate the origin of the HIV-1 viremia induced by the latency-reversing agent romidepsin. DESIGN: Six individuals on suppressive antiretroviral therapy received romidepsin administered intravenously once weekly for three consecutive weeks. CD4+ T-cells were obtained at baseline, following the second and third romidepsin infusion, and 10 weeks after the final romidepsin treatment. METHODS: Single-genome sequencing of the env region was used to genetically characterize the virus from proviral DNA, the transcribed cell-associated RNA and the plasma RNA pool...
January 19, 2017: AIDS
https://www.readbyqxmd.com/read/28106709/systemic-pharmacokinetics-and-pharmacodynamics-of-intravitreal-aflibercept-bevacizumab-and-ranibizumab
#7
Robert L Avery, Alessandro A Castellarin, Nathan C Steinle, Dilsher S Dhoot, Dante J Pieramici, Robert See, Stephen Couvillion, Maʼan A Nasir, Melvin D Rabena, Mauricio Maia, Sherri Van Everen, Kha Le, William D Hanley
PURPOSE: To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and ranibizumab in patients with neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), or retinal vein occlusion (RVO). METHODS: Prospective, open-label, nonrandomized clinical trial of patients with AMD, DME, or RVO who were antivascular endothelial growth factor (VEGF) naïve or had not received anti-VEGF for ≥4 months. Patients received 3 monthly intravitreal injections of aflibercept 2...
January 18, 2017: Retina
https://www.readbyqxmd.com/read/28106705/repair-of-orbital-floor-fracture-with-modified-transnasal-endoscopic-approach-through-anterior-space-to-nasolacrimal-duct
#8
Motohiko Suzuki, Yoshihisa Nakamura, Shinya Ozaki, Makoto Yokota, Shingo Murakami
OBJECTIVES: Endoscopic approach provides excellent magnification and visualization, and a purely transnasal approach is minimally invasive method. However, it is very difficult to repair anterior and lateral fractures with the previous transnasal endoscopic approaches, since repair of orbital fractures is managed through the middle meatus and ostium from the posterior side of the nasolacrimal duct with side-viewing endoscope and curved instruments. Therefore, the authors used modified transnasal endoscopic approach as an alternative for repair of orbital floor fractures in order to effectively reach the lateral or anterior fracture of the orbital floor with straight endoscope and instruments endoscopically...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106704/rapid-spontaneously-resolving-acute-subdural-hematoma
#9
Qi Gan, Hexiang Zhao, Hanmei Zhang, Chao You
INTRODUCTION: This study reports a rare patient of a rapid spontaneously resolving acute subdural hematoma. In addition, an analysis of potential clues for the phenomenon is presented with a review of the literature. PATIENT PRESENTATION: A 1-year-and-2-month-old boy fell from a height of approximately 2 m. The patient was in a superficial coma with a Glasgow Coma Scale of 8 when he was transferred to the authors' hospital. Computed tomography revealed the presence of an acute subdural hematoma with a midline shift beyond 1 cm...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106703/clinical-application-of-a-pedicled-forearm-flap-in-the-reconstruction-after-oral-cancer-resection
#10
Xiaoqiang Zhao, Youmei Zhang, Shuai Fu, Changbin Zhang, Ming Li, Yong Wu
OBJECTIVE: To investigate the clinical application of a pedicled forearm flap in the reconstruction of soft tissue defects after oral cancer resection. METHODS: A retrospective analysis was performed on 31 patients with oral cancer in the Affiliated Stomatology Hospital of Kunming Medical University. The patients underwent repair of soft tissue defects, resulting from oral cancer resection, using a pedicled forearm flap. Patients were followed up for 3 months to 3 years to observe the survival rate of the pedicled forearm flap and the recovery of the patient's appearance and oral function...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28104629/historian-accurate-reconstruction-of-ancestral-sequences-and-evolutionary-rates
#11
Ian H Holmes
MOTIVATION: Reconstruction of ancestral sequence histories, and estimation of parameters like indel rates, are improved by using explicit evolutionary models and summing over uncertain alignments. The previous best tool for this purpose (according to simulation benchmarks) was ProtPal, but this tool was too slow for practical use. RESULTS: Historian combines an efficient reimplementation of the ProtPal algorithm with performance-improving heuristics from other alignment tools...
January 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28104270/-teenagers-creating-art
#12
Jonathan Ahovi, Agathe Viverge
Teenagers need to interpret the world around them, sometimes in a completely different way to that in which, as children, they represented external reality. Some like drawing. They can use it to express their thoughts on death, sexuality or freedom. Their creative capacities are immense: they are creating art.
January 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28104268/-between-filiation-and-affiliation-constructing-an-identity-through-drawing-in-anorexia
#13
Lea Kalaora, Marie Reine Buzungu, Alice Titia Rizzi
Claire, a French-Korean teenager suffering from anorexia, favours drawing as a means of self-expression. Her graphic creations illustrate the search for identity of this child of migrants. Struggling with an impossible identification linked to her filiation, drawing represents for her a real object of mediation. It gives meaning to what dwells within her and constitutes the medium of her creativity.
January 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28104266/-teenagers-drawings-in-transcultural-consultations
#14
Amalini Simon, Alice Titia Rizzi
The place of teenagers' drawings has been studied as part of a transcultural consultation, based on the creativity of the children of migrants. When speaking is difficult, drawings enable teenagers to show another dimension of their internal world. Aravin, a young Tamil boy, who lacked the necessary words, was able to express all the complexity of his thoughts through his drawings, finally being able to formulate in the group the difficult situations which he was drawing.
January 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28104265/-the-importance-of-drawing-in-adolescence
#15
Alice Titia Rizzi
Teenagers like to draw. A drawing is a fundamental object of creativity in the process of re-construction and change typical of this period. However, theoretical approaches often consider that the evolution of the stages of drawing come to an end in adolescence. It is important to consider the practical and clinical benefit of drawing and to develop expression-based activities which can be carried out with this population.
January 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28100761/the-acceptability-of-self-sampled-screening-for-hpv-dna-a-systematic-review-and-meta-analysis
#16
REVIEW
Erik J Nelson, Brandy R Maynard, Travis Loux, Jessica Fatla, Rebecca Gordon, Lauren D Arnold
OBJECTIVE: To examine whether or not self-sampled cervical screening for human papillomavirus (HPV) DNA is acceptable and if women prefer self-sampling to clinician-based sampling. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Thirty-seven primary studies obtained through a comprehensive search of six electronic bibliographic databases from 1986 to 2014 and other sources. Search keywords included HPV, screening, DNA testing, vaginal testing, self-collected specimen, self-collected sample, self-sampling, self-screening, preferences and acceptability...
February 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28099408/multiphenotype-association-study-of-patients-randomized-to-initiate-antiretroviral-regimens-in-aids-clinical-trials-group-protocol-a5202
#17
Anurag Verma, Yuki Bradford, Shefali S Verma, Sarah A Pendergrass, Eric S Daar, Charles Venuto, Gene D Morse, Marylyn D Ritchie, David W Haas
BACKGROUND: High-throughput approaches are increasingly being used to identify genetic associations across multiple phenotypes simultaneously. Here, we describe a pilot analysis that considered multiple on-treatment laboratory phenotypes from antiretroviral therapy-naive patients who were randomized to initiate antiretroviral regimens in a prospective clinical trial, AIDS Clinical Trials Group protocol A5202. PARTICIPANTS AND METHODS: From among 5 9545 294 polymorphisms imputed genome-wide, we analyzed 2544, including 2124 annotated in the PharmGKB, and 420 previously associated with traits in the GWAS Catalog...
January 5, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28099402/transplant-center-volume-and-the-risk-of-pancreas-allograft-failure
#18
Tarek Alhamad, Andrew F Malone, Daniel C Brennan, Robert J Stratta, Su-Hsin Chang, Jason R Wellen, Timothy A Horwedel, Krista L Lentine
BACKGROUND: Successful pancreas transplantation requires surgical expertise and multidisciplinary medical management. The impact of transplant center volume on pancreas allograft survival remains unclear. METHODS: We examined Organ Procurement and Transplantation Network (OPTN) data on 11,568 simultaneous pancreas-kidney (SPK) and 4308 solitary pancreas (pancreas transplant alone and pancreas after kidney) transplants between 2000 and 2013. RESULTS: Average annual transplant center volume was categorized by tertiles into low, medium and high volume, respectively, as follows: 1-6 (n=3,861), 7-13 (n=3,891), and 14-34 (n=3,888) for SPK, and 1-3 (n=1,417), 4-10 (n=1,518), and 11-33 (n=1,377) for solitary pancreas transplants...
January 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28099314/fundus-autofluorescence-lifetimes-and-central-serous-chorioretinopathy
#19
Chantal Dysli, Lieselotte Berger, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To quantify retinal fluorescence lifetimes in patients with central serous chorioretinopathy (CSC) and to identify disease specific lifetime characteristics over the course of disease. METHODS: Forty-seven participants were included in this study. Patients with central serous chorioretinopathy were imaged with fundus photography, fundus autofluorescence, optical coherence tomography, and fluorescence lifetime imaging ophthalmoscopy (FLIO) and compared with age-matched controls...
January 17, 2017: Retina
https://www.readbyqxmd.com/read/28099286/multicenter-study-validating-accuracy-of-a-continuous-respiratory-rate-measurement-derived-from-pulse-oximetry-a-comparison-with-capnography
#20
Sergio D Bergese, Michael L Mestek, Scott D Kelley, Robert McIntyre, Alberto A Uribe, Rakesh Sethi, James N Watson, Paul S Addison
BACKGROUND: Intermittent measurement of respiratory rate via observation is routine in many patient care settings. This approach has several inherent limitations that diminish the clinical utility of these measurements because it is intermittent, susceptible to human error, and requires clinical resources. As an alternative, a software application that derives continuous respiratory rate measurement from a standard pulse oximeter has been developed. We sought to determine the performance characteristics of this new technology by comparison with clinician-reviewed capnography waveforms in both healthy subjects and hospitalized patients in a low-acuity care setting...
January 17, 2017: Anesthesia and Analgesia
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