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https://www.readbyqxmd.com/read/29922090/extramedullary-hematopoiesis-secondary-to-malignant-solid-tumors-a-case-report-and-literature-review
#1
Youting Bao, Zhichao Liu, Meiying Guo, Butuo Li, Xindong Sun, Linlin Wang
Extramedullary hematopoiesis (EMH) usually occurs in hematological disease, but more rarely develops in cases of malignant solid tumors. Due to its features on computed tomography (CT) and magnetic resonance imaging (MRI) that are atypical, EMH in tumor patients might easily be misdiagnosed as metastasis leading to the improper TNM staging and inappropriate therapy. Here, we reported the first case of pleural EMH occurring in a patient with esophageal carcinoma whose pleural lesion was first diagnosed as metastasis and confirmed EMH after the needle biopsy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29907488/correlation-of-regional-lung-ventilation-and-gas-transfer-to-red-blood-cells-implications-for-functional-avoidance-radiation-therapy-planning
#2
Leith J Rankine, Ziyi Wang, Bastiaan Driehuys, Lawrence B Marks, Chris R Kelsey, Shiva K Das
PURPOSE: To investigate the degree to which lung ventilation and gas exchange are regionally correlated, using the emerging technology of hyperpolarized (HP)-129 Xe magnetic resonance imaging (MRI). METHODS AND MATERIALS: Hyperpolarized-129 Xe MRI studies were performed on 17 institutional review board-approved human subjects, including 13 healthy volunteers, 1 emphysema patient, and 3 non-small cell lung cancer patients imaged before and approximately 11 weeks after radiation therapy (RT)...
April 14, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29905524/postoperative-re-irradiation-using-stereotactic-body-radiotherapy-for-metastatic-epidural-spinal-cord-compression
#3
Kei Ito, Keiji Nihei, Takuya Shimizuguchi, Hiroaki Ogawa, Tomohisa Furuya, Shurei Sugita, Takahiro Hozumi, Keisuke Sasai, Katsuyuki Karasawa
OBJECTIVE This study aimed to clarify the outcomes of postoperative re-irradiation using stereotactic body radiotherapy (SBRT) for metastatic epidural spinal cord compression (MESCC) in the authors' institution and to identify factors correlated with local control. METHODS Cases in which patients with previously irradiated MESCC underwent decompression surgery followed by spine SBRT as re-irradiation between April 2013 and May 2017 were retrospectively reviewed. The surgical procedures were mainly performed by the posterior approach and included decompression and fixation...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29904421/contrast-enhanced-magnetic-resonance-imaging-with-a-novel-nano-size-contrast-agent-for-the-clinical-diagnosis-of-patients-with-lung-cancer
#4
Jianwei Gao, Lei Li, Xia Liu, Rui Guo, Bin Zhao
Recent studies have indicated that magnetic resonance imaging (MRI) efficiently diagnoses lung cancer. However, the efficacy of MRI in diagnosing lung cancer requires improving for patients in the early stage of the disease. In the present study, a novel nano-sized contrast agent of chistosan/Fe3 O4 -enclosed bispecific antibodies (BsAbCENS) was introduced, which targeted carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) in lung cancer cells. The diagnostic efficacy of contrast-enhanced MRI with BsAbCENS (CEMRI-BsAbCENS) was investigated in a total of 182 patients with suspected lung cancer who had high serum levels of CEA and NSE...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29881714/mechanisms-and-therapy-for-cancer-metastasis-to-the-brain
#5
REVIEW
Federica Franchino, Roberta Rudà, Riccardo Soffietti
Advances in chemotherapy and targeted therapies have improved survival in cancer patients with an increase of the incidence of newly diagnosed brain metastases (BMs). Intracranial metastases are symptomatic in 60-70% of patients. Magnetic resonance imaging (MRI) with gadolinium is more sensitive than computed tomography and advanced neuroimaging techniques have been increasingly used in the detection, treatment planning, and follow-up of BM. Apart from the morphological analysis, the most effective tool for characterizing BM is immunohistochemistry...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29872593/retroperitoneal-metastasis-abutting-small-bowel-a-novel-magnetic-resonance-guided-radiation-approach
#6
Ahmed I Ghanem, Carri Glide-Hurst, M Salim Siddiqui, Indrin J Chetty, Benjamin Movsas
Stereotactic body radiation therapy (SBRT) is an option for selected patients with metastatic disease. However, sometimes these lesions are located in such close proximity to critical normal structures that the use of safe tumoricidal SBRT doses is not achievable. Here we present a case in which real-time imaging and tracking with a magnetic resonance linear accelerator (MR-LINAC) provided a novel treatment approach and enabled safe treatment of the tumor using SBRT. Our case is a 69-year-old female who presented with localized recurrent small cell lung cancer with a retroperitoneal (FDG-avid) soft tissue lesion measuring 2...
April 2, 2018: Curēus
https://www.readbyqxmd.com/read/29846642/comparison-of-68ga-pet-ct-to-other-imaging-studies-in-medullary-thyroid-cancer-superiority-in-detecting-bone-metastases
#7
Luciana Audi Castroneves, George Coura Filho, Ricardo Miguel Costa de Freitas, Raphael Salles, Raquel Ajub Moyses, Rossana Veronica Mendoza Lopez, Maria Adelaide Albergaria Pereira, Marcos Roberto Tavares, Alexsander Augusto de Lima Jorge, Carlos Alberto Buchpiguel, Ana Oliveira Hoff
Objective: Evaluate the efficacy of 68Ga PET/CT in detecting MTC lesions and evaluate tumor expression of somatostatin receptors (SSTR) associating with 68Ga PET/CT findings. Methods: Prospective study evaluating 30 MTC patients; Group 1 (N=16): Biochemical disease and Group 2 (N=14): Metastatic disease. Patients underwent 68Ga PET/CT, bone scan, neck CT and US, CT chest, CT/MRI abdomen, MRI spine. 68Ga PET/CT findings were analyzed by disease site as positive or negative and as concordant or discordant with conventional studies...
May 28, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29807678/seom-seram-semnim-guidelines-on-the-use-of-functional-and-molecular-imaging-techniques-in-advanced-non-small-cell-lung-cancer
#8
G Fernández Pérez, R Sánchez Escribano, A M García Vicente, A Luna Alcalá, J Ceballos Viro, R C Delgado Bolton, J C Vilanova Busquets, P Sánchez Rovira, M P Fierro Alanis, R García Figueiras, J E Alés Martínez
Imaging in oncology is an essential tool for patient management but its potential is being profoundly underutilized. Each of the techniques used in the diagnostic process also conveys functional information that can be relevant in treatment decision making. New imaging algorithms and techniques enhance our knowledge about the phenotype of the tumor and its potential response to different therapies. Functional imaging can be defined as the one that provides information beyond the purely morphological data, and include all the techniques that make it possible to measure specific physiological functions of the tumor, whereas molecular imaging would include techniques that allow us to measure metabolic changes...
May 25, 2018: Radiología
https://www.readbyqxmd.com/read/29805438/cryo-imaging-and-software-platform-for-analysis-of-molecular-mr-imaging-of-micrometastases
#9
Mohammed Q Qutaish, Zhuxian Zhou, David Prabhu, Yiqiao Liu, Mallory R Busso, Donna Izadnegahdar, Madhusudhana Gargesha, Hong Lu, Zheng-Rong Lu, David L Wilson
We created and evaluated a preclinical, multimodality imaging, and software platform to assess molecular imaging of small metastases. This included experimental methods (e.g., GFP-labeled tumor and high resolution multispectral cryo-imaging), nonrigid image registration, and interactive visualization of imaging agent targeting. We describe technological details earlier applied to GFP-labeled metastatic tumor targeting by molecular MR (CREKA-Gd) and red fluorescent (CREKA-Cy5) imaging agents. Optimized nonrigid cryo-MRI registration enabled nonambiguous association of MR signals to GFP tumors...
2018: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/29803524/use-of-magnetic-resonance-imaging-for-n-staging-in-patients-with-non-small-cell-lung-cancer-a-systematic-review
#10
Tara Pereiro Brea, Alberto Ruano Raviña, José Martín Carreira Villamor, Antonio Golpe Gómez, Anxo Martínez de Alegría, Luís Valdés
INTRODUCTION: The aim of this study is to assess the diagnostic value of the magnetic resonance imaging (MRI) in differentiating metastasic from non-metastatic lymph nodes in NSCLC patients compared with computed tomography (CT) and fluorodeoxyglucose (FDG) - positron emission tomography (PET) or both combined. METHODS: Twenty-three studies (19 studies and 4 meta-analysis) with sample size ranging between 22 and 250 patients were included in this analysis. MRI, regardless of the sequence obtained, where used for the evaluation of N-staging of NSCLC...
May 23, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29792040/lung-cancer-screening-with-mri-characterization-of-nodules-with-different-non-enhanced-mri-sequences
#11
Michael Meier-Schroers, Rami Homsi, Hans Heinz Schild, Daniel Thomas
Background There is increased interest in pulmonary magnetic resonance imaging (MRI) as a radiation-free alternative to computed tomography (CT) for lung cancer screening. Purpose To analyze MRI characteristics of pulmonary nodules with different non-enhanced sequences. Material and Methods Eighty-two participants of a lung cancer screening were included. MRI datasets of 32 individuals with 46 different nodules ≥ 6 mm were prospectively evaluated together with 50 controls by two readers. Acquired sequences were T2- short tau inversion recovery (STIR), T2, balanced steady-state free precession (bSSFP), 3D-T1, and diffusion-weighted imaging (DWI)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29785317/a-rare-case-of-penile-metastases-as-a-harbinger-of-primary-pulmonary-adenosquamous-carcinoma
#12
Partha Hota, Tejas N Patel, Xiaofeng Zhao, Carrie Schneider, Omar Agosto
Although lung cancer has a high propensity for distant metastatic disease, penile metastases from primary lung neoplasms are considered particularly rare. A 71-year-old male presented to our hospital with a rapidly enlarging hard palpable penile mass. MR imaging demonstrated two penile masses centered in the left and right corpus cavernosa. Subsequent CT imaging revealed a spiculated pulmonary mass in the right upper lobe with PET/CT, MRI, and surgical exploration, demonstrating evidence of metastases to the left adrenal gland, right subscapularis muscle, brain, and small bowel...
2018: Case Reports in Radiology
https://www.readbyqxmd.com/read/29774659/magnetic-resonance-imaging-evaluation-of-treatment-efficacy-and-prognosis-for-brain-metastases-in-lung-cancer-patients-after-radiotherapy-a-preliminary-study
#13
Yuhui Liu, Xibin Liu, Liang Xu, Liheng Liu, Yuhong Sun, Minghuan Li, Haiyan Zeng, Shuanghu Yuan, Jinming Yu
BACKGROUND: This study used magnetic resonance imaging (MRI) to monitor changes to brain metastases and investigate the imaging signs used to evaluate treatment efficacy and determine prognosis following radiotherapy for brain metastases from lung cancer. METHODS: A total of 60 non-small cell lung cancer patients with brain oligometastases were selected. MRI scans were conducted before and 3, 6, 9, 12, 18, 24, and 30 months after radiotherapy. The tumor and peritumoral edema diameters, Cho/Cr values, elevation of the Lip peak value, and whether the island (yu-yuan) sign or high-signal ring were present on T2 fluid-attenuated inversion recovery (FLAIR) imaging were recorded for each metastasis...
May 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29762233/adrenal-histoplasmosis
#14
Vanessa Sanders, Joseph Donald, Barry A Siegel
An 89-year-old woman presented with seizure and hyponatremia. CT and MRI demonstrated mass-like enlargement of the adrenal glands and multiple pulmonary nodules. PET/CT performed to evaluate for metastatic disease demonstrated intense 18F-FDG uptake within enlarged adrenal glands. Given mild uptake in the pulmonary nodules, the differential diagnosis for the adrenal uptake included lymphoma, granulomatous infection, and less likely, metastatic lung cancer.
May 14, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29761357/classifying-brain-metastases-by-their-primary-site-of-origin-using-a-radiomics-approach-based-on-texture-analysis-a-feasibility-study
#15
Rafael Ortiz-Ramón, Andrés Larroza, Silvia Ruiz-España, Estanislao Arana, David Moratal
OBJECTIVE: To examine the capability of MRI texture analysis to differentiate the primary site of origin of brain metastases following a radiomics approach. METHODS: Sixty-seven untreated brain metastases (BM) were found in 3D T1-weighted MRI of 38 patients with cancer: 27 from lung cancer, 23 from melanoma and 17 from breast cancer. These lesions were segmented in 2D and 3D to compare the discriminative power of 2D and 3D texture features. The images were quantized using different number of gray-levels to test the influence of quantization...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29756310/folate-receptor-targeted-19-f-mr-molecular-imaging-and-proliferation-evaluation-of-lung-cancer
#16
Xiuan Xu, Yuling Yan, Fang Liu, Lina Wu, Mengping Shao, Kai Wang, Xilin Sun, Yingbo Li, Ernest Sanyare Warmann Beinpuo, Baozhong Shen
BACKGROUND: Folate receptors (FRs) hold great potential as important diagnostic and prognostic biological marker for cancer. PURPOSE: To assess the targeted capability of the FR-targeted perfluorocarbon (PFC) nanoparticles and to assess in vivo the relationship between FR expression and tumor proliferation with fluorine-19 (19 F) MR molecular imaging. STUDY TYPE: Prospective animal cancer model. ANIMAL MODEL: H460 (n = 14) and A549 (n = 14) nude mice subcutaneous tumor models...
May 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29742611/falciform-ligament-artery-uptake-on-99mtc-maa-planning-scan-before-90y-sirt-confirmed-by-retrospective-spect-mri-fusion
#17
Nils Große Hokamp, Carsten Kobe, James K O'Donnell, Amit Gupta
Selective internal radiation therapy using Y spheres is a treatment option for patients with primary or secondary liver cancer. To avoid complications, screening using Tc macroaggregated albumin is performed to identify lung shunting and extrahepatic depositions. For the latter, deposition after the anterior abdominal wall is frequently attributed to a patent falciform artery, although the vessel itself is rarely visible on SPECT/CT scans. We demonstrate that retrospective SPECT/MRI fusion clearly attributes the nuclide accumulation to a patent falciform artery...
April 30, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29724418/acr-appropriateness-criteria-%C3%A2-pretreatment-staging-of-muscle-invasive-bladder-cancer
#18
Christian B van der Pol, V Anik Sahni, Steven C Eberhardt, Aytekin Oto, Oguz Akin, Lauren F Alexander, Brian C Allen, Fergus V Coakley, Adam T Froemming, Pat F Fulgham, Keyanoosh Hosseinzadeh, Jodi K Maranchie, Rekha N Mody, Nicola Schieda, David M Schuster, Aradhana M Venkatesan, Carolyn L Wang, Mark E Lockhart
Muscle-invasive bladder cancer (MIBC) has a tendency toward urothelial multifocality and is at risk for local and distant spread, most commonly to the lymph nodes, bone, lung, liver, and peritoneum. Pretreatment staging of MIBC should include imaging of the urothelial upper tract for synchronous lesions; imaging of the chest, abdomen, and pelvis for metastases; and MRI pelvis for local staging. CT abdomen and pelvis without and with contrast (CT urogram) is recommended to assess the urothelium and abdominopelvic organs...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29718880/various-clinical-features-of-patients-with-anti-hu-associated-paraneoplastic-neurological-syndromes-an-observational-study
#19
Jia Li, Weihong Lin
To describe and analyze the clinical features and prognosis of patients with anti-Hu associated paraneoplastic neurological syndromes (PNS).The symptoms, MRI findings, cerebrospinal fluid (CSF) changes, electroencephalogram (EEG) characteristics and prognoses of 9 well-diagnosed anti-Hu associated PNS patients were analyzed.The study enrolled 6 female and 3 male patients. Three patients presented with vertigo and 6 patients exhibited a depressed mood, numbness of the lower limbs, generalized pains, seizures, mental disturbances, and a temporary unilateral hand tremor on initial presentation...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29710025/-a-survivor-of-hodgkin-lymphoma-manifesting-dropped-head-syndrome-as-a-late-onset-complication-of-radiotherapy-a-case-report
#20
Misako Kaido, Yoshihito Yuasa, Hiroshi Ikeda
We report the case of a 50-year-old female survivor of Hodgkin lymphoma (HL), who developed dropped head syndrome (DHS). The patient was diagnosed with HL at 20 years of age, and underwent chemo-radiotherapy, which led to complete remission. Undergoing supplemental therapy for post-radiation hypothyroidism, she had twin babies. She noticed white stains on her neck at the age of 30, and the decolored area gradually expanded. Sixteen years after the radiotherapy (RT), her posterior neck muscle strength began to decline...
May 25, 2018: Rinshō Shinkeigaku, Clinical Neurology
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