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Etiology prevalence chronic kidney disease

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https://www.readbyqxmd.com/read/29769014/effect-of-fluoride-on-major-organs-with-the-different-time-of-exposure-in-rats
#1
Thanusha Perera, Shirani Ranasinghe, Neil Alles, Roshitha Waduge
BACKGROUND: High fluoride levels in drinking water in relation to the prevalence of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka were investigated using rats as an experimental model. METHOD: The effects of fluoride after oral administration of Sodium fluoride (NaF) at levels of 0, 0.5, 5 and 20 ppm F- were evaluated in adult male Wistar rats. Thirty-six rats were randomly divided into 4 groups (n = 9), namely, control, test I, II, and III...
May 16, 2018: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29686466/nutrition-status-and-helicobacter-pylori-infection-in-patients-receiving-hemodialysis
#2
REVIEW
Mitsushige Sugimoto, Hideo Yasuda, Akira Andoh
Chronic kidney disease (CKD) patients receiving hemodialysis (HD) often develop gastrointestinal abnormalities over their long treatment period. In general, prognosis in such patients is poor due to the development of protein-energy wasting (PEW). Therefore, it is important to clarify the etiology of PEW and to establish better strategies to deal with this condition. Chronic Helicobacter pylori ( H. pylori ) infection in the gastric mucosa has a close association with not only the development of peptic ulcer disease and gastric cancer, but is also associated with abnormal plasma and gastric mucosal ghrelin levels that are seen in malnutrition...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29657211/etiological-profile-of-chronic-kidney-disease-a-single-center-retrospective-hospital-based-study
#3
Manjuri Sharma, Prodip Doley, Himanab Jyoti Das
Chronic kidney disease (CKD) is one of the leading causes of chronic diseases globally, with rising incidence and prevalence. It is a major risk factor for cerebrovascular disease and coronary artery disease, which are the main causes of death in this population. The etiology of CKD is varied. This study was performed to evaluate the various etiologies of CKD among patients presenting to the Department of Nephrology, Guwahati Medical College, a tertiary referral center. A total of 5718 CKD patients were evaluated to identify the cause of CKD...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29584721/multimorbidity-in-patients-with-heart-failure-from-11-asian-regions-a-prospective-cohort-study-using-the-asian-hf-registry
#4
Jasper Tromp, Wan Ting Tay, Wouter Ouwerkerk, Tiew-Hwa Katherine Teng, Jonathan Yap, Michael R MacDonald, Kirsten Leineweber, John J V McMurray, Michael R Zile, Inder S Anand, Carolyn S P Lam
BACKGROUND: Comorbidities are common in patients with heart failure (HF) and complicate treatment and outcomes. We identified patterns of multimorbidity in Asian patients with HF and their association with patients' quality of life (QoL) and health outcomes. METHODS AND FINDINGS: We used data on 6,480 patients with chronic HF (1,204 with preserved ejection fraction) enrolled between 1 October 2012 and 6 October 2016 in the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29509436/developmental-origins-of-non-alcoholic-fatty-liver-disease-as-a-risk-factor-for-exaggerated-metabolic-and-cardiovascular-renal-disease
#5
Frank T Spradley, Jillian A Smith, Barbara T Alexander, Christopher D Anderson
Intrauterine growth restriction (IUGR) is linked to increased risk for chronic disease. Placental ischemia and insufficiency in the mother are implicated in predisposing IUGR offspring to metabolic dysfunction, including hypertension, insulin resistance, abnormalities in glucose homeostasis, and non-alcoholic fatty liver disease (NAFLD). Whether these metabolic disturbances contribute to the developmental origins of exaggerated cardiovascular-renal disease (CVRD) risk accompanying IUGR is unclear. IUGR impacts the pancreas, adipose tissue, and liver, which are hypothesized to program for hepatic insulin resistance and subsequent NAFLD...
March 6, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29471290/presence-of-kidney-disease-as-an-outcome-predictor-in-patients-with-pulmonary-arterial-hypertension
#6
Laurent Bitker, Florence Sens, Cécile Payet, Ségolène Turquier, Antoine Duclos, Vincent Cottin, Laurent Juillard
BACKGROUND: Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced estimated GFR (eGFR) and the association of CKD with survival in PAH patients. METHODS: In a prospective PAH cohort (2003-2012), invasive hemodynamics and eGFR were collected at diagnosis (179 patients) and during follow-up (159 patients)...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29456222/prevalence-and-risk-factors-of-chronic-kidney-disease-in-cote-d-ivoire-an-analytic-study-conducted-in-the-department-of-internal-medicine
#7
Hubert Kouame Yao, Serge Didier Konan, Sindou Sanogo, Sery Patrick Diopoh, Amadou Demba Diallo
Chronic kidney disease (CKD) has become a public health problem because of its increasing prevalence. The objective of this study was to describe the current profile of CKD in our working conditions. This is a descriptive retrospective study of patients admitted for CKD during the period from January 2010 to December 2014 in the Internal Medicine Department of the university hospital of Treichville in Abidjan. CKD was defined by a glomerular filtration rate below 60 mL/min lasting for at least three months...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29259716/resident-fibroblasts-in-the-kidney-a-major-driver-of-fibrosis-and-inflammation
#8
REVIEW
Yuki Sato, Motoko Yanagita
Background: Chronic kidney disease (CKD) is a leading cause of end stage renal disease (ESRD) and cardiovascular morbidity and mortality worldwide, resulting in a growing social and economic burden. The prevalence and burden of CKD is anticipated to further increase over the next decades as a result of aging. Main body of abstract: In the pathogenesis of CKD, irrespective of the etiology, resident fibroblasts are key players and have been demonstrated to play crucial roles for disease initiation and progression...
2017: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29240709/prevalence-of-albuminuria-in-children-living-in-a-rural-agricultural-and-fishing-subsistence-community-in-lake-chapala-mexico
#9
Felipe Lozano-Kasten, Erick Sierra-Diaz, Alfredo de Jesus Celis-de la Rosa, María Margarita Soto Gutiérrez, Alejandro Aarón Peregrina Lucano
The occurrence of Chronic Kidney Disease (CKD) of unknown etiology in autochthonous child populations residing along the Lake Chapala lakeshore is endemic (Jalisco, México). The objective of this study was to determine the prevalence of albuminuria in the pediatric population and to measure the glomerular filtration rate in children with two positive albuminuria tests. Urinary albumin was measured in 394 children. Subjects with two or more positive albuminuria test donated blood samples for the determination of serum biomarkers...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29230260/-epidemiological-features-of-cardiorenal-syndrome-a-study-of-36-cases-in-the-cardiology-department-in-dakar
#10
Malick Bodian, Awa Thiaw, Simon Antoine Sarr, Kana Babaka, Fatou Aw, Aliou Alassane Ngaïde, Mouhamadou Bamba Ndiaye, Adama Kane, Modou Jobe, Alassane Mbaye, Maboury Diao, Moustapha Sarr, Serigne Abdou Ba
Introduction: Cardiorenal syndrome (CRS) is a pathophysiologic disorder of the heart and the kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. In Africa, particularly in Senegal, the incidence of cardiorenal syndrome is not accurately known. This study aimed to assess the prevalence of CRS in the Cardiology Department. Methods: We conducted a retrospective study including all patients with heart failure associated with alteration of renal function, hospitalized in the Cardiology Department between April 2010 and April 2011...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29193154/prevalence-and-predictors-of-peripheral-neuropathy-in-nondiabetic-children-with-chronic-kidney-disease
#11
Sangeetha Yoganathan, Arvind Bagga, Sheffali Gulati, G S Toteja, Pankaj Hari, Aditi Sinha, Ravindra Mohan Pandey, Mohammad Irshad
INTRODUCTION: This study sought to determine the prevalence and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease (CKD). METHODS: Fifty-one consecutive normally nourished children, 3-18 years of age, with CKD stages IV and V of nondiabetic etiology were enrolled from May to December 2012. Nerve conduction studies were performed in 50 children. Blood samples were analyzed for the biochemical parameters, trace elements, and micronutrients...
November 29, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29173296/waist-circumference-and-body-mass-index-in-children-with-chronic-kidney-disease-and-metabolic-cardiovascular-and-renal-outcomes
#12
MULTICENTER STUDY
Hiren P Patel, Jeffrey M Saland, Derek K Ng, Shuai Jiang, Bradley A Warady, Susan L Furth, Joseph T Flynn
OBJECTIVE: To describe the prevalence of obesity as estimated by waist circumference (WC) and body mass index (BMI) and compare associations of WC and BMI with indicators of metabolic, cardiovascular, and renal health in children with chronic kidney disease (CKD). STUDY DESIGN: Cross-sectional analysis stratified by CKD etiology (nonglomerular or glomerular) of 737 subjects. The kappa statistic was used to assess agreement between the 2 measures of obesity. Linear regression models were performed using WC and BMI as separate independent variables...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29163729/prevalence-comorbidity-and-investigation-of-anemia-in-the-primary-care-office
#13
Shivani Jatin Gandhi, Iris Hagans, Karim Nathan, Krystal Hunter, Satyajeet Roy
Background: Anemia has a myriad of causes and its prevalence is growing. Anemia is associated with increased all-cause hospitalization and mortality in community-dwelling individuals above age 65 years. Our aim was to determine the prevalence and severity of anemia in adult patients in our primary care office and to determine the relationship between anemia and medical comorbidities. Methods: Electronic medical records of 499 adult patients in our suburban internal medicine office were reviewed who had had at least one hemoglobin value and did not undergo moderate to high-risk surgery in the preceding 30 days...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29141943/anemia-at-older-age-etiologies-clinical-implications-and-management
#14
REVIEW
Reinhard Stauder, Peter Valent, Igor Theurl
Anemia is quite frequently diagnosed in older individuals and is a key indicator of various reactive and clonal conditions. Many underlying diseases, like myelodysplastic syndrome (MDS), develop preferentially in elderly individuals. The prevalence of anemia at older age is increasing, and this is mainly attributable to more frequently applied diagnostics and demographic changes in our societies. The etiology of anemia at older age is complex and ranges from bone marrow failure syndromes to chronic kidney disease, and from nutritional deficiencies to inflammatory processes including inflammaging in immunosenescence...
February 1, 2018: Blood
https://www.readbyqxmd.com/read/28979781/2017-update-on-pain-management-in-patients-with-chronic-kidney-disease
#15
Phuong Chi Pham, Kathy Khaing, Theodore M Sievers, Phuong Mai Pham, Jeffrey M Miller, Son V Pham, Phuong Anh Pham, Phuong Thu Pham
The prevalence of pain has been reported to be >60-70% among patients with advanced and end-stage kidney disease. Although the underlying etiologies of pain may vary, pain per se has been linked to lower quality of life and depression. The latter is of great concern given its known association with reduced survival among patients with end-stage kidney disease. We herein discuss and update the management of pain in patients with chronic kidney disease with and without requirement for renal replacement therapy with the focus on optimizing pain control while minimizing therapy-induced complications...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28948847/geochemical-and-isotopic-evidences-from-groundwater-and-surface-water-for-understanding-of-natural-contamination-in-chronic-kidney-disease-of-unknown-etiology-ckdu-endemic-zones-in-sri-lanka
#16
E A N V Edirisinghe, H Manthrithilake, H M T G A Pitawala, H A Dharmagunawardhane, R L Wijayawardane
Chronic kidney disease of unknown etiology (CKDu) is the main health issue in the dry zone of Sri Lanka. Despite many studies carried out, causative factors have not been identified yet clearly. According to the multidisciplinary researches carried out so far, potable water is considered as the main causative factor for CKDu. Hence, the present study was carried out with combined isotopic and chemical methods to understand possible relationships between groundwater; the main drinking water source, and CKDu in four endemic areas in the dry zone...
September 26, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28926845/leptospirosis-renal-disease-emerging-culprit-of-chronic-kidney-disease-unknown-etiology
#17
Chih-Wei Yang
Leptospirosis is the most prevalent zoonosis affecting more than 1 million populations worldwide. Interestingly, leptospirosis endemic regions coincide with chronic kidney disease (CKD) hotspots largely due to flooding and agricultural overlaps. Acute leptospirosis induces multiple organ dysfunction including acute kidney injury and may predispose to CKD and end-stage renal disease, if not treated timely. Asymptomatic infection may carry the bacteria in the kidney and CKD progresses insidiously. Histologic finding of leptospirosis renal disease includes tubulointerstitial nephritis, interstitial fibrosis, and tubular atrophy...
2018: Nephron
https://www.readbyqxmd.com/read/28904428/collapsing-glomerulopathy-a-troublemaker-for-the-renal-allograft-lessons-learnt
#18
K V Kanodia, A V Vanikar, L K Nigam, R D Patel, K S Suthar, H V Patel, H L Trivedi
Collapsing glomerulopathy (CG) is a well-recognized distinct morphological pattern of proliferative parenchymal injury leading to rapid graft failure. We conducted a single-center retrospective study to evaluate the prevalence, clinicopathological features, and prognosis of CG in renal transplant recepient. We analyzed 2518 renal allograft biopsies performed from 2007 to 2015 and correlated their clinicopathological features. The prevalence of CG was 0.83% (21 out of 2518) of allograft biopsies with a higher prevalence of 1...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28864964/chronic-kidney-disease-of-unknown-etiology-and-the-effect-of-multiple-ion-interactions
#19
M W C Dharma-Wardana
High incidence of chronic kidney disease of unknown etiology (CKDU) prevalent in many countries (e.g., Sri Lanka, equatorial America) is reviewed in the context of recent experimental work and using our understanding of the hydration of ions and proteins. Qualitative considerations based on Hofmeister-type action of these ions, as well as quantitative electrochemical models for the Gibbs free energy change for ionpair formation, are used to explain why (1) fluoride and water hardness due to magnesium ions (but not due to calcium ions) and similarly (2) cadmium ions in the presence of suitable pairing ions can be expected to be more nephrotoxic, while arsenite in the presence of fluoride and hardness may be expected to be less nephrotoxic...
April 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28770948/curative-treatment-of-hypertension-by-physical-exercise
#20
M Lou, X-F Zong, L-L Wang
Hypertension, one of the most common chronic and sporadic conditions, figures among the important worldwide public-health challenges, and it is a major risk for heart disease, stroke, kidney disease and other complications, including dementia. Hypertension is neglected by individuals, and the prevalence of this condition continues to rise across the world. A great number of patients receiving medical intervention is not successfully treated, while adequate curative health services are dependent on the exact update data of the countrywide prevalence of known and undetected cases...
July 2017: European Review for Medical and Pharmacological Sciences
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