Ke Zhang, Shuo Zheng, Jiasheng Wu, Jing He, Yu Ouyang, Chunchun Ao, Ruibo Lang, Yijia Jiang, Yifan Yang, Huan Xiao, Yu Li, Mao Li, Huiming Wang, Changyong Li, Dongcheng Wu
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. Currently, there are no effective drugs for the treatment of DN. Although several studies have reported the therapeutic potential of mesenchymal stem cells, the underlying mechanisms remain largely unknown. Here, we report that both human umbilical cord MSCs (UC-MSCs) and UC-MSC-derived exosomes (UC-MSC-exo) attenuate kidney damage, and inhibit epithelial-mesenchymal transition (EMT) and renal fibrosis in streptozotocin-induced DN rats...
April 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology