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https://www.readbyqxmd.com/read/28749409/host-response-comparison-of-h1n1-and-h5n1-infected-mice-identifies-two-potential-death-mechanisms
#1
Olivier Leymarie, Léa Meyer, Pierre-Louis Hervé, Bruno Da Costa, Bernard Delmas, Christophe Chevalier, Ronan Le Goffic
Highly pathogenic influenza A viruses (IAV) infections represent a serious threat to humans due to their considerable morbidity and mortality capacities. A good understanding of the molecular mechanisms responsible for the acute lung injury observed during this kind of infection is essential to design adapted therapies. In the current study, using an unbiased transcriptomic approach, we compared the host-responses of mice infected with two different subtypes of IAV: H1N1 vs. H5N1. The host-response comparison demonstrated a clear difference between the transcriptomic profiles of H1N1- and H5N1-infected mice despite identical survival kinetics and similar viral replications...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28748988/-characterization-of-patients-with-sporadic-colorectal-cancer-following-the-new-consensus-molecular-subtypes-cms
#2
Ana María Wielandt, Cynthia Villarroel, Claudia Hurtado, Daniela Simian, Diego Zamorano, Maripaz Martínez, Magdalena Castro, María Teresa Vial, Udo Kronberg, Francisco López-Kostner
BACKGROUND: Colorectal cancer (CRC) is an heterogeneous disease. Three carcinogenic pathways determine its molecular profile: microsatellite instability (MSI), chromosomal instability (CIN) and CpG island methylator phenotype (CIMP). Based on the new molecular classification, four consensus CRC molecular subtypes (CMS) are established, which are related to clinical, pathological and biological characteristics of the tumor. AIM: To classify Chilean patients with sporadic CRC according to the new consensus molecular subtypes of carcinogenic pathways...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748917/oesophageal-cancer
#3
REVIEW
Elizabeth C Smyth, Jesper Lagergren, Rebecca C Fitzgerald, Florian Lordick, Manish A Shah, Pernilla Lagergren, David Cunningham
Oesophageal cancer is the sixth most common cause of cancer-related death worldwide and is therefore a major global health challenge. The two major subtypes of oesophageal cancer are oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC), which are epidemiologically and biologically distinct. OSCC accounts for 90% of all cases of oesophageal cancer globally and is highly prevalent in the East, East Africa and South America. OAC is more common in developed countries than in developing countries...
July 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28748599/a-comparison-of-statistical-methods-for-the-study-of-etiologic-heterogeneity
#4
Emily C Zabor, Colin B Begg
Cancer epidemiologic research has traditionally been guided by the premise that certain diseases share an underlying etiology, or cause. However, with the rise of molecular and genomic profiling, attention has increasingly focused on identifying subtypes of disease. As subtypes are identified, it is natural to ask the question of whether they share a common etiology or in fact arise from distinct sets of risk factors. In this context, epidemiologic questions of interest include (1) whether a risk factor of interest has the same effect across all subtypes of disease and (2) whether risk factor effects differ across levels of each individual tumor marker of which the subtypes are comprised...
July 26, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28748495/evidence-for-interactions-between-homocysteine-and-genistein-insights-into-stroke-risk-and-potential-treatment
#5
Zyta Banecka-Majkutewicz, Leszek Kadziński, Michał Grabowski, Sylwia Bloch, Rajmund Kaźmierkiewicz, Joanna Jakóbkiewicz-Banecka, Magdalena Gabig-Cimińska, Grzegorz Węgrzyn, Alicja Węgrzyn, Bogdan Banecki
Elevated plasma homocysteine (2-amino-4-sulfanylbutanoic acid) level is a risk factor for stroke. Moreover, it has been suggested that high levels of homocysteine in the acute phase of an ischemic stroke can predict mortality, especially in stroke patients with the large-vessel atherosclerosis subtype. In clinical studies, supplementation with genistein (5, 7-dihydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one) decreased plasma homocysteine levels considerably. Therefore, genistein could be considered as a potential drug for prevention and/or treatment of stroke...
July 26, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28748061/host-molecular-factors-and-viral-genotypes-in-the-mother-to-child-hiv-1-transmission-in-sub-saharan-africa
#6
REVIEW
Linda Chapdeleine M Mouafo, Béatrice Dambaya, Nicole N Ngoufack, Céline N Nkenfou
Maternal viral load and immune status, timing and route of delivery, viral subtype, and host genetics are known to influence the transmission, acquisition and disease progression of human immunodeficiency virus-1 (HIV-1) infection. This review summarizes the findings from published works on host molecular factors and virus genotypes affecting mother to child transmission (MTCT) in Africa and identifies the gaps that need to be addressed in future research. Articles in PubMed, Google and AIDSearch and relevant conference abstracts publications were searched...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28747572/serum-ca125-is-a-predictive-marker-for-breast-cancer-outcomes-and-correlates-with-molecular-subtypes
#7
Cheng Fang, Yue Cao, Xiaoping Liu, Xian-Tao Zeng, Yirong Li
Detection of serum tumor markers has been developed as a non-invasive tool to assess treatment efficiency in different types of cancer. This study aims to investigate the role of preoperative serum tumor markers (CEA, CA125 and CA15-3) in the management of breast cancer, and their relationships with patients' clinicopathological parameters as well as different molecular subtypes. Altogether, 151 patients with invasive breast cancer and 180 control subjects with benign breast diseases were enrolled in this study...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747339/clinical-significance-of-four-molecular-subtypes-of-gastric-cancer-identified-by-the-cancer-genome-atlas-project
#8
Bo Hwa Sohn, Jun-Eul Hwang, Hee-Jin Jang, Hyun-Sung Lee, Sang Cheul Oh, Jae-Jun Shim, Keun-Wook Lee, Eui Hyun Kim, Sun Young Yim, Sang Ho Lee, Jae-Ho Cheong, Woojin Jeong, Jae Yong Cho, Joohee Kim, Jungsoo Chae, Jeeyun Lee, Won Ki Kang, Sung Kim, Sung Hoon Noh, Jaffer A Ajani, Ju-Seog Lee
Purpose: The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein-Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN). However, their clinical significances are currently unknown. We aimed to investigate the relationship between subtypes and prognosis of patients with gastric cancer.Experimental Design: Gene expression data from a TCGA cohort (n = 262) were used to develop a subtype prediction model, and the association of each subtype with survival and benefit from adjuvant chemotherapy was tested in 2 other cohorts (n = 267 and 432)...
July 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28747131/association-of-preoperative-breast-mri-features-with-locoregional-recurrence-after-breast-conservation-therapy
#9
Min Sun Bae, Jung Min Chang, Nariya Cho, Wonshik Han, Han Suk Ryu, Woo Kyung Moon
Background Locoregional recurrence (LRR) following breast conservation therapy (BCT) is associated with an increased risk of distant metastasis and death in patients with breast cancer. Purpose To investigate whether preoperative breast magnetic resonance imaging (MRI) features are associated with the risk of LRR in patients undergoing BCT. Material and Methods A total of 3781 women with primary invasive breast cancer underwent preoperative MRI and BCT between 2003 and 2013. Forty-eight patients who developed LRR comprised the LRR cohort and one-to-one matching (age, tumor stage, grade, and axillary nodal status) of each patient to a control participant was performed in patients who did not develop recurrence...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28746837/vitamin-d-and-breast-cancer-past-and-present
#10
JoEllen Welsh
The presence of the vitamin D receptor in mammary gland and breast cancer has been recognized since the early 1980s, and multiple pre-clinical studies have demonstrated that its ligand 1,25D modulates normal mammary gland development and sensitivity to carcinogenesis. Although studies have characterized many 1,25D responsive targets in normal mammary cells and in breast cancers, validation of relevant targets that regulate cell cycle, apoptosis, autophagy and differentiation, particularly in vivo, has been challenging...
July 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28746804/solid-phase-synthesis-of-hydroxamic-acids-and-identification-of-hdac-inhibitors-using-a-chemi-luminescence-based-assay
#11
Claus Bang, Jakob Jensen, Emil Cohrt, Lasse Olsen, Saba Siyum, Kim Mortensen, Tine S Poulsen, Jens Berthelsen, Liang Yang, Michael Givskov, Katrine Qvortrup, Thomas Eiland Nielsen
We herein present broadly useful, readily available and non-integral hydroxylamine linkers for the routine solid-phase synthesis of hydroxamic acids. The Fmoc-protected linkers are readily made on multi-gram scale from simple starting materials and conveniently attached to solid support through standard amide bond forming reactions. The developed protocols enable the efficient synthesis and release of a wide range of hydroxamic acids from various resins, relying on high control and flexibility with respect to reagents and synthetic processes...
July 26, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28745550/improvising-5-ht7r-homology-model-for-design-of-high-affinity-ligands-model-validation-with-docking-embrace-minimization-mm-gbsa-and-molecular-dynamic-simulations
#12
Preeti Jha, Shubhra Chaturvedi, Swastika, Sunil Pal, Nidhi Jain, Anil K Mishra
The subtype, 5-HT7R has been implicated in neurological disorders and presents itself as a promising target for antidepressant drugs. Design of targeted selective ligands, require a sound knowledge of 3D-receptor structure. In absence of receptor structure, structure based design of targeted ligands relies on generation of 5-HT7R homology model. In this study, the impact of template choice, alignment and model building methods on the homology model of 5-HT7R is addressed. The compactness and model quality due to the presence of cholesterol (lipidic receptor) have also been observed...
July 26, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28743687/tp73-dna-methylation-and-upregulation-of-%C3%AE-np73-are-associated-with-an-adverse-prognosis-in-breast-cancer
#13
Laura C Gomez, Mayra L Sottile, Martin E Guerrero-Gimenez, Felipe C M Zoppino, Analia L Redondo, Francisco E Gago, Javier I Orozco, Olga M Tello, Maria Roqué, Silvina B Nadin, Diego M Marzese, Laura M Vargas-Roig
AIM: Accumulated evidence suggests that aberrant methylation of the TP73 gene and increased levels of ΔNp73 in primary tumours correlate with poor prognosis. However, little is known regarding the transcriptional and functional regulation of the TP73 gene in breast cancer. The aim of the present study was to determine the expression of the ΔNp73 isoform, its relationship with DNA methylation of TP73 and their clinical prognostic significance in breast cancer patients. METHODS: TP73 gene methylation was studied in TCGA datasets and in 70 invasive ductal breast carcinomas (IDCs)...
July 25, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28742689/lymphangiogenic-gene-expression-is-associated-with-lymph-node-recurrence-and-poor-prognosis-after-partial-hepatectomy-for-colorectal-liver-metastasis
#14
Thomas T Vellinga, Onno Kranenburg, Nicola Frenkel, Inge Ubink, Dieuwke Marvin, Klaas Govaert, Susanne van Schelven, Jeroen Hagendoorn, Inne H Borel Rinkes
OBJECTIVES: To investigate the relevance of lymphangiogenic gene expression in primary and liver metastasis of colorectal cancer (CRC) and identify determinants of lymphatic invasion. BACKGROUND: Lymphatic development promoting vascular endothelial growth factor C (VEGFC) is associated with poor outcome in primary CRC. For colorectal liver metastasis (CRLM), intrahepatic lymph invasion and lymph node metastasis are poor prognostic factors. Exact biological factors promoting lymphatic involvement remain elusive, just as the association with molecular subtypes of CRC...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742265/congenital-disorders-of-glycosylation-the-saudi-experience
#15
Sarah Alsubhi, Amal Alhashem, Eissa Faqeih, Majid Alfadhel, Abdullah Alfaifi, Waleed Altuwaijri, Saud Alsahli, Hesham Aldhalaan, Fowzan S Alkuraya, Khalid Hundallah, Adel Mahmoud, Ali Alasmari, Fuad Al Mutairi, Hanem Abduraouf, Layan AlRasheed, Saad Alshahwan, Brahim Tabarki
We retrospectively reviewed Saudi patients who had a congenital disorder of glycosylation (CDG). Twenty-seven Saudi patients (14 males, 13 females) from 13 unrelated families were identified. Based on molecular studies, the 27 CDG patients were classified into different subtypes: ALG9-CDG (8 patients, 29.5%), ALG3-CDG (7 patients, 26%), COG6-CDG (7 patients, 26%), MGAT2-CDG (3 patients, 11%), SLC35A2-CDG (1 patient), and PMM2-CDG (1 patient). All the patients had homozygous gene mutations. The combined carrier frequency of CDG for the encountered founder mutations in the Saudi population is 11...
July 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28741479/colorectal-cancer-subtypes-developmental-origin-and-microenvironmental-regulation
#16
REVIEW
Evelyn Fessler, Jan Paul Medema
Cancer is a heterogeneous disease and many cancer types do not represent a single entity, but are composed of biologically and clinically diverse subtypes. The subtype affiliation can influence prognosis and response to therapy. Recently, a multicenter colorectal cancer (CRC) subtyping consortium introduced a consensus molecular classification system for CRC. This will be of great benefit for future basic and clinical research since it enables uniform categorization of CRC specimens across different institutes and studies...
September 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28740920/pathologic-response-after-neoadjuvant-chemotherapy-predicts-locoregional-control-in-patients-with-triple-negative-breast-cancer
#17
Victor E Chen, Erin F Gillespie, Kaveh Zakeri, James D Murphy, Catheryn M Yashar, Sharon Lu, John P Einck
PURPOSE: Our goal was to determine the impact of pathologic response after neoadjuvant chemotherapy in triple negative breast cancer (TNBC) on the subsequent risk of locoregional recurrence (LRR) and disease-free survival (DFS) in the setting of adjuvant radiation therapy. METHODS AND MATERIALS: This was an institutional review board-approved retrospective chart review of patients with clinical stage I-III breast cancer treated with neoadjuvant chemotherapy, local surgery (breast conservation or mastectomy), and adjuvant radiation therapy between 1997 and 2015...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28739799/lgr5-receptor-promotes-cell-cell-adhesion-in-stem-cells-and-colon-cancer-cells-via-the-iqgap1-rac1-pathway
#18
Kendra S Carmon, Xing Gong, Jing Yi, Ling Wu, Anthony Thomas, Catherine M Moore, Ikuo Masuho, David J Timson, Kirill A Martemyanov, Qingyun J Liu
Leucine rich repeat containing G protein coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most notably in the intestinal crypts and is highly upregulated in many colorectal, hepatocellular, and ovarian cancers. LGR5 activation by R-spondin (RSPO) ligands potentiates Wnt/β-catenin signaling in vitro, yet deletion of LGR5 in stem cells has little or no effect on Wnt/β-catenin signaling or cell proliferation in vivo. Remarkably, modulation of LGR5 expression has a major impact on the actin cytoskeletal structure and cell adhesion in the absence of RSPO stimulation, but the molecular mechanism is unclear...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28739739/transcriptional-profiling-of-sonic-hedgehog-in-a-prospective-cohort-of-breast-cancer-in-a-pakistani-population
#19
Syeda Kiran Riaz, Lin Ye, Namood E Sahar, Durkhshan Aman, Javeria Qadir, Jahangir Sarwar Khan, Muhammad Saeed, Wen G Jiang, Muhammad Faraz Arshad Malik
BACKGROUND/AIM: Constitutive activation of Sonic hedgehog (SHH) has been observed in different types of cancers. In the present study, expressional profiling of SHH in a breast cancer cohort (n=150) of a Pakistani population and its association with different molecular subtypes have been explored. MATERIALS AND METHODS: qRT-PCR and IHC were performed for expression analysis of SHH and its association with ER, PR, HER2 and Ki-67 were also statistically analyzed. RESULTS: A significant over-expression of SHH was observed in tumor tissues in comparison to their respective controls (p<0...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738471/-association-between-phage-mediated-shiga-toxin-and-molecular-distribution-of-crispr-in-escherichia-coli-o26-%C3%A2-h11-or-nm
#20
J Z Long, Y K Xu, G C Duan, W J Liang, H Y Liu, S Y Chen, Y L Xi, P F Wang, Y F Wang
Objective: To investigate the association between phage-mediated shiga toxin and molecular distribution of CRISPR in Escherichia (E.) coli O26∶H11 or NM. Methods: A total of 135 E. coli O26 ∶ H11 or NM strains were collected from NCBI database. Software CRT and CRISPR Finder were used to extract CRISPR and Excel was used to assign the spacer of unique number and type CRISPR. And the relationship between CRISPR and stx phage was analyzed. Results: All the 135 E. coli O26 ∶ H11 or NM strains had the CRISPR...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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