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https://www.readbyqxmd.com/read/29166711/-effects-of-caspase-1-inhibitor-vx765-on-cold-restraint-stress-induced-acute-gastric-ulcer-in-mice
#1
S Q Zheng, X D Hong, T S Chen, P F Luo, S C Xiao
Objective: To investigate the protective effects of caspase-1 inhibitor VX765 on gastric mucosa of mice with cold-restraint stress-induced acute gastric ulcer. Methods: Twenty-four specific pathogen free male C57BL/6J mice were divided into normal control group (NC), cold restrain group (CR), VX765 pre-treatment+ cold restrain group (VCR), and rabeprazole pre-treatment+ cold restrain group (RCR) according to the random number table, with 6 mice in each group. Mice in group NC were injected intraperitoneally with solution of 10 mL/kg dimethylsulfoxide (DMSO) and phosphate buffer solution (PBS)...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166709/-effects-of-dexmedetomidine-on-myocardium-of-rats-with-severe-burn-at-early-stage
#2
D Wang, P L Yang, X Zhang, Y Liu
Objective: To investigate the effects of dexmedetomidine on myocardium of rats at early stage after severe burn. Methods: Twenty specific pathogen free male SD rats were immersed in 90 ℃ hot water for 20 s, causing 30% total body surface area (TBSA) full-thickness scald (hereafter referred to as burn) on the back. And then they were divided into burn resuscitation group (BR) and burn resuscitation+ dexmedetomidine group (BRD) according to the random number table, with 10 rats in each group. Sodium lactate Ringer's solution (2 mL·kg(-1)·%TBSA(-1)) were intraperitoneally injected into rats of both groups after burn...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166690/-facial-emotion-recognition-theory-of-mind-and-empathy-in-multiple-sclerosis
#3
Samar S Ayache, Moussa A Chalah, Tania Kuempfel, Frank Padberg, Jean-Pascal Lefaucheur, Ulrich Palm
Multiple sclerosis (MS), a chronic progressive inflammatory disease of the central nervous system, causes frequent disability, mood disorders, fatigue, and cognitive dysfunction. As a part of the last, social cognition is frequently disturbed in MS patients. It comprises empathy and social perception of emotions from facial, bodily and vocal cues. Social cognitive deficits worsen affect decoding, interpersonal relationship, and quality of life. Despite the impact of these deficits on global functioning, only a small number of studies have investigated its correlations and overlaps with MS symptoms...
November 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29166679/work-related-musculoskeletal-disorders-among-plastic-surgeons-a-systematic-review
#4
Sherise Epstein, Bao N Tran, Avery C Capone, Qing Z Ruan, Bernard T Lee, Dhruv Singhal
No abstract text is available yet for this article.
November 22, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29166674/unpredictable-chronic-mild-stress-differentially-impairs-social-and-contextual-discrimination-learning-in-two-inbred-mouse-strains
#5
Michiel van Boxelaere, Jason Clements, Patrick Callaerts, Rudi D'Hooge, Zsuzsanna Callaerts-Vegh
Alterations in the social and cognitive domain are considered important indicators for increased disability in many stress-related disorders. Similar impairments have been observed in rodents chronically exposed to stress, mimicking potential endophenotypes of stress-related psychopathologies such as major depression disorder (MDD), anxiety, conduct disorder, and posttraumatic stress disorder (PTSD). Data from numerous studies suggest that deficient plasticity mechanisms in hippocampus (HC) and prefrontal cortex (PFC) might underlie these social and cognitive deficits...
2017: PloS One
https://www.readbyqxmd.com/read/29166669/frequency-of-five-disease-causing-genetic-mutations-in-a-large-mixed-breed-dog-population-2011-2012
#6
Sharon Zierath, Angela M Hughes, Neale Fretwell, Mark Dibley, Kari J Ekenstedt
BACKGROUND: A large and growing number of inherited genetic disease mutations are now known in the dog. Frequencies of these mutations are typically examined within the breed of discovery, possibly in related breeds, but nearly always in purebred dogs. No report to date has examined the frequencies of specific genetic disease mutations in a large population of mixed-breed dogs. Further, veterinarians and dog owners typically dismiss inherited/genetic diseases as possibilities for health problems in mixed-breed dogs, assuming hybrid vigor will guarantee that single-gene disease mutations are not a cause for concern...
2017: PloS One
https://www.readbyqxmd.com/read/29166624/impact-of-processing-methods-on-the-dissolution-of-artemether-from-two-non-ordered-mesoporous-silicas
#7
Hira Tahir, Yasser Shahzad, Laura J Waters, Talib Hussain, Abid Mehmood Yousaf, Tariq Mahmood, Rizwan Sheikh
Poor aqueous solubility is often linked with a poor dissolution rate and ultimately, limited bioavailability of pharmaceutical compounds. This study describes the application of mesoporous materials (Syloid 244 and Syloid AL1) in improving the dissolution rate of a drug with poor aqueous solubility, namely artemether, utilising different processing methods including physical mixing, co-grinding and solid dispersions prepared by solvent evaporation and the lyophilisation technique. The prepared formulations were extensively characterised for their solid-state properties and the drug release attributes were studied...
November 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29166585/brain-immunity-gut-big-links-between-pregnancy-and-autism
#8
Myka L Estes, A Kimberley McAllister
Although dysregulation of brain, immune, and gut physiology during pregnancy have each been implicated in neuropsychiatric disorders, whether and how these presumably distinct systems are linked to cause disease is unclear. Kim et al. (2017) and Shin Yim et al. (2017) identify a pathway to explain how these aspects of our physiology are deeply and inextricably connected.
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166576/the-beneficial-health-aspects-of-sea-buckthorn-elaeagnus-rhamnoides-l-a-nelson-oil
#9
REVIEW
Beata Olas
ETHNOPHARMACOLOGICAL CONTEXT: Plant oils are known to have biological activity. This review paper summarizes the current knowledge of the composition of sea buckthorn (Elaeagnus rhamnoides (L.) A.Nelson) seed and pulp oil and its beneficial health aspects. MATERIALS AND METHODS: In vitro and in vivo studies on humans and animals have found sea buckthorn oil to have a variety of beneficial properties to human health, and indicate that it may be a valuable component of human and animal nutrition...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29166564/optical-control-of-dopamine-receptors-using-a-photoswitchable-tethered-inverse-agonist
#10
Prashant Donthamsetti, Nils Winter, Matthias Schönberger, Joshua Levitz, Cherise Stanley, Jonathan A Javitch, Ehud Y Isacoff, Dirk Trauner
Family A G protein-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance. Their archetype rhodopsin becomes naturally light sensitive by binding covalently to the photoswitchable tethered ligand (PTL) retinal. Other GPCRs, however, neither bind covalently to ligands nor are light sensitive. We sought to impart the logic of rhodopsin to light-insensitive Family A GPCRs in order to enable their remote control in a receptor-specific, cell-type-specific and spatio-temporally precise manner...
November 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29166552/vortioxetine-versus-placebo-in-major-depressive-disorder-comorbid-with-social-anxiety-disorder
#11
Michael R Liebowitz, Jason Careri, Kyra Blatt, Ann Draine, Junko Morita, Melissa Moran, Rita Hanover
BACKGROUND: Major Depressive Disorder (MDD) and Social Anxiety Disorder (SAD) are highly comorbid, yet the combined condition has not been subject to any placebo-controlled treatment trials. This study reports a trial of vortioxetine, an antidepressant that has also shown benefit in Generalized Anxiety Disorder (GAD), in patients meeting DSM-5 criteria for both MDD and SAD. METHODS: The study was a 12-week double-blind, placebo-controlled comparison of vortioxetine 10-20 mg/day or placebo administered on a 1:1 ratio...
November 22, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29166502/outcomes-of-long-term-treatments-of-type-i-hereditary-angioedema-in-a-turkish-family
#12
Gulsen Akoglu, Belgin Kesim, Gokhan Yildiz, Ahmet Metin
BACKGROUND: Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks. OBJECTIVE: We aimed to investigate the clinical and genetic features of a family with angioedema attacks. METHODS: The medical history, clinical features and C1-INH gene mutation of a Turkish family were investigated and outcomes of long-term treatments were described. RESULTS: Five members had experienced recurrent swellings on the face and extremities triggered by trauma...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166501/primary-cutaneous-t-cell-lymphoma-experience-from-the-peruvian-national-cancer-institute
#13
Rosana Ruiz, Zaida Morante, Raul Mantilla, Luis Mas, Luis Casanova, Henry L Gomez
BACKGROUND: Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America. OBJECTIVE: To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution. METHODS: Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagnosis. Classification was performed following the 2008 World Health Organization Classification of Neoplasms of the Hematopoietic and Lymphoid tissues...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#14
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166496/recurrent-aphthous-stomatitis-in-18-year-old-adolescents-prevalence-and-associated-factors-a-population-based-study
#15
Paulo Ricardo Martins de Souza, Rodrigo Pereira Duquia, Juliano de Avelar Breunig, Hiram Larangeira de Almeida
BACKGROUND: Recurrent aphthous stomatitis is a painful disorder of unknown etiology. It is among the most common oral mucosal lesions with high prevalence among young adults. OBJECTIVES: To conduct a population-based study with 18-year-old army recruiters to assess its prevalence and associated factors in male adolescents. METHODS: Interview during clinical examination in the army. RESULTS: In this group (2,427 interviewed adolescents) there was a RAS prevalence of 24...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166486/-narratives-of-users-of-mental-health-services-in-an-experiment-with-autonomous-management-of-medication
#16
Laura Lamas Martins Gonçalves, Rosana Teresa Onocko Campos
Numerous studies have highlighted the tendency to chronicity of treatments centered on the use of medications. This study was conducted in a large Brazilian city with users of Centers for Psychosocial Care (CAPS), with the aim of evaluating the effects of experimenting with the personal Guide for Autonomous Management of Medication (GAM) and the users' relationship to their treatments and participation. The instrument, created in Canada and translated and adapted to Brazil, was tested in intervention groups with users of CAPS with severe mental disorders and a history of political participation in the field of health...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166458/mog-igg-associated-optic-neuritis-is-not-multiple-sclerosis
#17
Bruna Klein da Costa, Giordani Rodrigues Dos Passos, Jefferson Becker, Douglas Kazutoshi Sato
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON. METHODS AND RESULTS: Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166451/factors-associated-with-frailty-in-a-community-dwelling-population-of-older-adults
#18
Danielle Teles da Cruz, Marcel de Toledo Vieira, Ronaldo Rocha Bastos, Isabel Cristina Gonçalves Leite
OBJECTIVE: To analyze if demographic and socioeconomic factors and factors related to health and health services are associated with frailty in community-dwelling older adults. METHODS: This is a cross-sectional study with 339 older adults (60 years old or more) living in Juiz de Fora, State of Minas Gerais, Brazil, in 2015. A household survey was carried out and frailty was evaluated using the Edmonton Frail Scale. For the analysis of the factors associated with outcome, a theoretical model of determination was constructed with three hierarchical blocks: block 1 with demographic and socioeconomic characteristics, block 2 with the health of the older adult (divided into three sub-levels: 2...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166447/prevalence-and-clinical-profile-of-chronic-pain-and-its-association-with-mental-disorders
#19
Flávia Garcia Pereira, Mariane Henriques França, Maria Cristina Alochio de Paiva, Laura Helena Andrade, Maria Carmen Viana
OBJECTIVE: To identify the prevalence of 12-month self-reported pain and chronic pain in a general population and to describe their clinical profile to assess if chronic pain is associated with 12-month mental disorders. METHODS: The data used comes from the São Paulo Megacity Mental Health Survey, a population-based study assessing adult (≥ 18 years) residents of the São Paulo metropolitan area, Brazil. We have assessed the respondents (n = 5,037) using the Composite International Diagnostic Interview (CIDI 3...
November 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166440/maternal-complications-and-cesarean-section-without-indication-systematic-review-and-meta-analysis
#20
Keila Cristina Mascarello, Bernardo Lessa Horta, Mariângela Freitas Silveira
OBJECTIVE: The objective of this study was to determine the risks of severe acute maternal complications associated with cesarean section without medical indication. METHODS: A systematic review was carried out with meta-analysis. The literature search was performed systematically, in multiple stages, in the PubMed, Lilacs, and Web of Science databases using the following descriptors: (postpartum period) and (cesarean section or natural childbirth) and ((morbidity or mortality) or (postpartum hemorrhage) or (puerperal infection) or (surgical infection) or (puerperal disorders))...
2017: Revista de Saúde Pública
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