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https://www.readbyqxmd.com/read/27920480/comparison-of-multichannel-intraluminal-impedance-ph-monitoring-and-reflux-scintigraphy-in-pediatric-patients-with-suspected-gastroesophageal-reflux
#1
Nuray Uslu Kızılkan, Murat Fani Bozkurt, Inci Nur Saltık Temizel, Hülya Demir, Aysel Yüce, Biray Caner, Hasan Özen
AIM: To evaluate the agreement of multichannel intraluminal impedance-pH monitoring (MII-pHM) and gastroesophageal reflux scintigraphy (GES) for the diagnosis of gastroesophageal reflux disease. METHODS: Seventy-five consecutive patients with suspected gastroesophageal reflux disease (GERD) underwent 24-h combined MII-pHM recording and one hour radionuclide scintigraphy during the course of the MII-pHM study. Catheters with 6 impedance channels and 1 pH sensor were placed transnasally...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27905291/two-cases-of-myiasis-of-middle-ear-caused-by-sarcophaga
#2
Erdal Polat, Serhat Sirekbasan, Hakkı Caner İnan
Middle ear myiasis and factors determining the types of flies. To the laboratory in saline with 10% formaldehyde and sent them larvae stereo-microscope (Olympus 10×) were examined. Adult by making one portion of the surviving larvae instar larvae and adults are defined utilizing state properties. The larvae and live larvae of the fly Sarcophaga sp. rendered adults were determined. In both patients, the middle ear causing myiasis flies species Sarcophaga sp. was determined to be.
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27903984/association-between-xrcc1-polymorphisms-and-the-risk-of-cervical-cancer-a-meta-analysis-based-on-4895-subjects
#3
Xianling Zeng, Yafei Zhang, Ting Yue, Taohong Zhang, Junxia Wang, Yan Xue, Ruifang An
The present meta-analysis was intended to explore the relationship between the x-ray repair cross complementing 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His and Arg399Gln) and cervical cancer risk. Several electronic databases were searched systematically and bibliographies of relevant papers were identified carefully. Then, a meta-analysis was performed based on eligible studies in various genetic models. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were employed to evaluate the strength of associations between the XRCC1 polymorphisms and cervical cancer risk...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819650/efficacy-of-cortexin-and-methylprednisolone-on-traumatic-facial-nerve-paralysis
#4
Tuncay Tunçcan, Şinasi Yalçın, Caner Feyzi Demir, Mehmet Mustafa Akın, Turgut Karlıdağ, Erol Keleş, İrfan Kaygusuz
OBJECTIVE: The aim was to investigate the efficacy of cortexin and methylprednisolone on recovery in cases of traumatic facial nerve paralysis occurring after facial nerve trauma. MATERIALS AND METHODS: The study was performed on 21 healthy rabbits. The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred. The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group), Group II (methylprednisolone group), and Group III (control group), respectively...
November 7, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27773428/biallelic-mutations-in-tmtc3-encoding-a-transmembrane-and-tpr-containing-protein-lead-to-cobblestone-lissencephaly
#5
Julie Jerber, Maha S Zaki, Jumana Y Al-Aama, Rasim Ozgur Rosti, Tawfeg Ben-Omran, Esra Dikoglu, Jennifer L Silhavy, Caner Caglar, Damir Musaev, Beate Albrecht, Kevin P Campbell, Tobias Willer, Mariam Almuriekhi, Ahmet Okay Çağlayan, Jiri Vajsar, Kaya Bilgüvar, Gonul Ogur, Rami Abou Jamra, Murat Günel, Joseph G Gleeson
Cobblestone lissencephaly (COB) is a severe brain malformation in which overmigration of neurons and glial cells into the arachnoid space results in the formation of cortical dysplasia. COB occurs in a wide range of genetic disorders known as dystroglycanopathies, which are congenital muscular dystrophies associated with brain and eye anomalies and range from Walker-Warburg syndrome to Fukuyama congenital muscular dystrophy. Each of these conditions has been associated with alpha-dystroglycan defects or with mutations in genes encoding basement membrane components, which are known to interact with alpha-dystroglycan...
November 3, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27756128/evaluation-of-the-significance-of-starch-surface-binding-sites-on-human-pancreatic-%C3%AE-amylase
#6
Xiaohua Zhang, Sami Caner, Emily Kwan, Chunmin Li, Gary D Brayer, Stephen G Withers
Starch provides the major source of caloric intake in many diets. Cleavage of starch into malto-oligosaccharides in the gut is catalyzed by pancreatic alpha-amylase. These oligosaccharides are then further cleaved by gut wall alpha-glucosidases to release glucose, which is absorbed into the bloodstream. Potential surface binding sites for starch on the pancreatic amylase, distinct from the active site of the amylase, have been identified through X-ray crystallographic analyses. The role of these sites in the degradation of both starch granules and soluble starch was probed by the generation of a series of surface variants modified at each site to disrupt binding...
October 19, 2016: Biochemistry
https://www.readbyqxmd.com/read/27751753/effect-of-white-noise-in-relieving-vaccination-pain-in-premature-infants
#7
Sibel Kucukoglu, Aynur Aytekin, Ayda Celebioglu, Arzu Celebi, Ibrahim Caner, Rukiye Maden
The purpose of this study was to evaluate the effect of white noise as a distraction method in relieving procedural pain caused by vaccination for premature infants. This experimental study was performed at a neonatal intensive care unit (NICU) of a university hospital in Turkey between July and September 2013. The study population was composed of 75 premature infants (35 in the study group and 40 in the control group) who met the inclusion criteria. Premature infants in the study group were exposed to white noise using MP3 players placed at the head of the infants' open crib for 1 minute before vaccination...
October 14, 2016: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/27747588/trpv6-is-a-prognostic-marker-in-early-stage-cervical-squamous-cell-carcinoma
#8
Fei Sun, Lu Xiao, Xin-Xing Jang, Ying Xiong, Qi Li, Xiao-Jing Yue, Yun-Jian Wei, Yan-Xing Wei, Yan-Lin Ma, Yan-Hong Yu
Transient receptor potential vanilloid 6 (TRPV6) has been shown to promote caner proliferation in several solid tumors, leading to unfavorable clinical outcomes. Our study aimed to elucidate the clinical significance of TRPV6 in patients with early-stage cervical squamous cell carcinoma (CSCC). The mRNA expression of TRPV6 was measured in 12 paired early-stage CSCC specimens and six cervical carcinoma cell lines using quantitative real-time PCR (qRT-PCR). Western blotting and immunohistochemistry (IHC) were employed to examine the protein expression level of TRPV6 in four paired specimens, 175 paraffin-embedded early-stage CSCC specimens, and 50 normal cervical tissues (NCTs), respectively...
October 17, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27713130/increased-gene-expression-noise-in-human-cancers-is-correlated-with-low-p53-and-immune-activities-as-well-as-late-stage-cancer
#9
Rongfei Han, Guanqun Huang, Yejun Wang, Yafei Xu, Yueming Hu, Wenqi Jiang, Tianfu Wang, Tian Xiao, Duo Zheng
Gene expression in metazoans is delicately organized. As genetic information transmits from DNA to RNA and protein, expression noise is inevitably generated. Recent studies begin to unveil the mechanisms of gene expression noise control, but the changes of gene expression precision in pathologic conditions like cancers are unknown. Here we analyzed the transcriptomic data of human breast, liver, lung and colon cancers, and found that the expression noise of more than 74.9% genes was increased in cancer tissues as compared to adjacent normal tissues...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27699219/profiling-cancer-testis-antigens-in-non-small-cell-lung-cancer
#10
Dijana Djureinovic, Björn M Hallström, Masafumi Horie, Johanna Sofia Margareta Mattsson, Linnea La Fleur, Linn Fagerberg, Hans Brunnström, Cecilia Lindskog, Katrin Madjar, Jörg Rahnenführer, Simon Ekman, Elisabeth Ståhle, Hirsh Koyi, Eva Brandén, Karolina Edlund, Jan G Hengstler, Mats Lambe, Akira Saito, Johan Botling, Fredrik Pontén, Mathias Uhlén, Patrick Micke
Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small-cell lung cancer (NSCLC), we compared RNAseq data from 199 NSCLC tissues to the normal transcriptome of 142 samples from 32 different normal organs. Of 232 CTAs currently annotated in the Caner Testis Database (CTdatabase), 96 were confirmed in NSCLC. To obtain an unbiased CTA profile of NSCLC, we applied stringent criteria on our RNAseq data set and defined 90 genes as CTAs, of which 55 genes were not annotated in the CTdatabase, thus representing potential new CTAs...
July 7, 2016: JCI Insight
https://www.readbyqxmd.com/read/27689764/bioconjugation-and-applications-of-amino-functional-fluorescence-polymers
#11
Caner Geyik, Emine Guler, Zinar Pinar Gumus, Firat Baris Barlas, Huseyin Akbulut, Dilek Odaci Demirkol, Suna Timur, Yusuf Yagci
Synthesis and novel applications of biofunctional polymers for diagnosis and therapy are promising area involving various research domains. Herein, three fluorescent polymers, poly(p-phenylene-co-thiophene), poly(p-phenylene), and polythiophene with amino groups (PPT-NH2 , PPP-NH2 , and PT-NH2 , respectively) are synthesized and investigated for cancer cell targeted imaging, drug delivery, and radiotherapy. Polymers are conjugated to anti-HER2 antibody for targeted imaging studies in nontoxic concentrations...
September 30, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27685776/the-false-positive-responses-of-analgesic-drugs-to-the-intradermal-serotonin-and-compound-48-80-induced-scratches-as-an-animal-model-of-itch
#12
Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin
Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27661111/association-between-tumor-stroma-ratio-and-prognosis-in-solid-tumor-patients-a-systematic-review-and-meta-analysis
#13
Jiayuan Wu, Caixia Liang, Manyu Chen, Wenmei Su
Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor-stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field of predicting tumor prognosis. However, the prognostic value of TSR in solid tumors necessitates further elucidation. We conducted a meta-analysis on 14 studies with 4238 patients through a comprehensive electronic search on databases updated on May 2016 to explore the relationship between TSR and prognosis of solid tumors. The overall hazard ratio showed that rich stroma in tumor tissue was associated with poor overall survival (OS) (14 studies, 4238 patients) and disease-free survival (DFS) (9 studies, 2235 patients) of patients with solid tumors...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27647985/the-inflammatory-cytokine-interleukin-23-is-elevated-in-lung-cancer-particularly-small-cell-type
#14
Caner Cam, Bulent Karagoz, Tuba Muftuoglu, Oguz Bigi, Levent Emirzeoglu, Serkan Celik, Alpaslan Ozgun, Tolga Tuncel, Cihan Top
AIM OF THE STUDY: Interleukin (IL)-17 and IL-23 play roles in inflammation and autoimmunity. The function of the IL-17/IL-23 pathway has not been completely evaluated in cancer patients. We aimed to investigate serum IL-17 and IL-23 levels and their relationship with clinicopathological and biochemical parameters in lung cancer patients. MATERIAL AND METHODS: Forty-five lung cancer patients and 46 healthy volunteers were included in the study. IL-17 and IL-23 measurements were made with the ELISA method...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27621846/gram-negative-bacteria-facilitate-tumor-outgrowth-and-metastasis-by-promoting-lipid-synthesis-in-lung-cancer-patients
#15
Maosong Ye, Xia Gu, Yang Han, Meiling Jin, Tao Ren
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. Patients with lung cancer are very frequently present with pulmonary infections, in particular with Gram-negative bacteria. Herein, we investigated the effect of the co-presence of Gram-negative bacteria on outgrowth and metastasis of lung cancer cells in clinical patients. METHODS: Lung cancer cells were isolated from clinical surgical tissues. Heat-inactivated E. coli was used as Gram-negative bacteria...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27613829/dihydroartemisinin-suppresses-pancreatic-cancer-cells-via-a-microrna-mrna-regulatory-network
#16
Yilong Li, Yongwei Wang, Rui Kong, Dongbo Xue, Shangha Pan, Hua Chen, Bei Sun
Despite improvements in surgical procedures and chemotherapy, pancreatic cancer remains one of the most aggressive and fatal human malignancies, with a low 5-year survival rate of only 8%. Therefore, novel strategies for prevention and treatment are urgently needed. Here, we investigated the mechanisms underlying the anti-pancreatic cancer effects dihydroartemisinin (DHA). Microarray and systematic analysis showed that DHA suppressed proliferation, inhibited angiogenesis and promoted apoptosis in two different human pancreatic cancer cell lines, and that 5 DHA-regulated microRNAs and 11 of their target mRNAs were involved in these effects via 19 microRNA-mRNA interactions...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27612419/nc886-a-non-coding-rna-and-suppressor-of-pkr-exerts-an-oncogenic-function-in-thyroid-cancer
#17
Eun Kyung Lee, Seung-Hyun Hong, Sooyong Shin, Hyun-Sung Lee, Ju-Seog Lee, Eun Jung Park, Sun Shim Choi, Jae Woong Min, Daeyoon Park, Jung-Ah Hwang, Betty H Johnson, Sung Ho Jeon, In-Hoo Kim, Yeon-Su Lee, Yong Sun Lee
nc886 is a recently identified cellular non-coding RNA and its depletion leads to acute cell death via PKR (Protein Kinase RNA-activated) activation. nc886 expression is increased in some malignancies, but silenced in others. However, the precise role of nc886/PKR is controversial: is it a tumor suppressor or an oncogene? In this study, we have clarified the role of nc886 in thyroid cancer by sequentially generating PKR knockout (KO) and PKR/nc886 double KO cell lines from Nthy-ori 3-1, a partially transformed thyroid cell line...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27598613/-comparison-of-90%C3%A2-and-180%C3%A2-plate-constructions-for-comminuted-distal-humerus-fractures-in-adults-and-effects-on-clinical-results
#18
Volkan Eryuva, Taşkın Altay, Cemil Kayalı, Zafer Kement, Caner Çıtak
BACKGROUND: The present objective was to compare 90° and 180° double-plate constructions for complex distal humerus fractures, as well as to evaluate superiority of construction type. METHODS: Retrospectively evaluated were 17 patients treated for type C distal humerus fracture according to AO/ASIF classification between January 2009 and January 2013. All attended minimum 6-month follow-up. Elbow function was assessed with anteroposterior and lateral x-ray, and Mayo elbow performance score evaluation at outpatient clinics...
July 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27592107/postoperative-changes-in-sacropelvic-junction-in-short-segment-angular-kyphosis-versus-scheuermann-kyphosis
#19
Olcay Guler, Turgut Akgul, Murat Korkmaz, Caner Gunerbuyuk, Kerim Sariyilmaz, Fatih Dikici, Ufuk Talu
PURPOSE: To comparatively evaluate the biomechanical alterations those occur in the sagittal plane of sacropelvic junction in angular kyphosis (AK) and Scheuermann kyphosis (SK) patients after surgery. METHODS: The spine radiographs of 52 patients operated for short-segment AK (n = 20) or SK (n = 32) were studied. Main outcome measures were sacral slope, pelvic incidence, pelvic tilt, lumbar lordosis, and thoracic kyphosis angles. RESULTS: In AK group, local and thoracic kyphosis angles, as well as lumbar lordosis angle, showed statistically significant reduction with surgery...
September 3, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27586866/theophylline-controllable-rnai-based-genetic-switches-regulate-expression-of-lncrna-tincr-and-malignant-phenotypes-in-bladder-cancer-cells
#20
Zhicong Chen, Yuchen Liu, Anbang He, Jianfa Li, Mingwei Chen, Yonghao Zhan, Junhao Lin, Chengle Zhuang, Li Liu, Guoping Zhao, Weiren Huang, Zhiming Cai
TINCR is a well-known lncRNA which acts as a master regulator in somatic differentiation development. However, it is still unclear whether TINCR is also involved in caner occurrence and progression. In this study, we observed that TINCR was up-regulated in bladder cancer tissues and cells and contributed to oncogenesis and cancer progression. Silencing TINCR expression inhibited cell proliferation and promoted apoptosis in vitro, indicating that TINCR may be the potential therapeutic target for treating bladder urothelial carcinoma...
2016: Scientific Reports
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