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https://www.readbyqxmd.com/read/28816044/action-of-gold-nanospikes-based-nanoradiosensitizers-cellular-internalization-radiotherapy-and-autophagy
#1
Ningning Ma, Peidang Liu, Nongyue He, Ning Gu, Fu-Gen Wu, Zhan Chen
A major challenge to achieve effective X-ray radiation therapy is to use a relatively low and safe radiation dose. Various radiosensitizers, which can significantly enhance the radiotherapeutic performance, have been developed. Gold-based nanomaterials, as a new type of nanoparticle-based radiosensitizers, have been extensively used in researches involving cancer radiotherapy. However, the cancer therapeutic effect using the gold nanoparticle-based radiotherapy is usually not significant because of the low cellular uptake efficiency and the autophagy-inducing ability of these gold nanomaterials...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28796539/carbonic-anhydrase-i-ii-autoantibodies-and-oxidative-status-in-long-term-follow-up-of-patients-with-crimean-congo-haemorrhagic-fever
#2
Hülya Yilmaz, Uğur Kostakoğlu, Selim Demir, Firdevs Aksoy, Ahmet Menteşe, Süleyman Caner Karahan, İftihar Köksal, Ahmet Alver, Gürdal Yilmaz
CONTEXT: Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease. OBJECTIVE: This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and of CA I-II autoantibodies as biomarkers for autoimmunity and course of disease in patients with CCHF. METHODS: Seventy CCHF patients and 39 healthy control volunteers were included in the study...
August 10, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28782469/immune-checkpoint-inhibitors-basics-and-challenges
#3
Bin Li, Ho Lam Chan, Pingping Chen
Cancer is one of the most deadly diseases in modern world. The last decade has witnessed dramatic advances in the cancer treatment through immunotherapy. One extremely promising means to achieve anti-caner immunity is to block the immune checkpoint pathways, which mechanism was adopted by cancer cells to disguise themselves as regular components of human body. While checkpoint blockade is universally effective against a broad spectrum of cancer types and mostly unrestricted by certain gene mutation status, only a minority of patients achieved a complete response to such treatment...
August 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28777387/increased-levels-of-circulating-cd34-cells-in-neovascular-age-related-macular-degeneration-relation-with-clinical-and-oct-features
#4
Caner Kara, Pınar Ç Özdal, Emrullah Beyazyıldız, Nurgül E Özcan, Mehmet Y Teke, Gülden Vural, Faruk Öztürk
PURPOSE: To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings. METHODS: The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry...
August 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28757355/15-lipoxygenase-1-re-expression-in-colorectal-cancer-alters-endothelial-cell-features-through-enhanced-expression-of-tsp-1-and-icam-1
#5
Sinem Tunçer, Ayşe Gökçe Keşküş, Melis Çolakoğlu, Ismail Çimen, Caner Yener, Özlen Konu, Sreeparna Banerjee
15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been shown to inhibit neoangiogenesis in colorectal cancer (CRC); in the present study we confirm this phenomenon and describe the mechanistic basis. We show that re-expression of 15-LOX-1 in CRC cell lines resulted in decreased transcriptional activity of HIF1α and reduced the expression and secretion of VEGF in both normoxic and hypoxic conditions...
July 28, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28754809/ventricular-function-and-vascular-dimensions-after-norwood-and-hybrid-palliation-of-hypoplastic-left-heart-syndrome
#6
Heiner Latus, Mohamed S Nassar, James Wong, Pauline Hachmann, Hannah Bellsham-Revell, Tarique Hussain, Christian Apitz, Caner Salih, Conal Austin, David Anderson, Can Yerebakan, Hakan Akintuerk, Juergen Bauer, Reza Razavi, Dietmar Schranz, Gerald Greil
OBJECTIVE: Norwood and hybrid procedure are two options available for initial palliation of patients with hypoplastic left heart syndrome (HLHS). Our study aimed to assess potential differences in right ventricular (RV) function and pulmonary artery dimensions using cardiac magnetic resonance (CMR) in survivors with HLHS. METHODS: 42 Norwood (mean age 2.4±0.8) and 44 hybrid (mean age 2.0±1.0 years) patients were evaluated by CMR after stage II palliation prior to planned Fontan completion...
July 28, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28741273/can-a-hand-radiograph-indicate-a-special-diagnosis-in-a-child-with-chronic-kidney-disease-answers
#7
Eren Soyaltın, Belde Kasap-Demir, Caner Alparslan, Seçil Arslansoyu-Çamlar, Elif Perihan Öncel, Özgür Kırbıyık, Demet Alaygut, Önder Yavaşcan, Gamze Türe, Fatma Mutlubaş
No abstract text is available yet for this article.
July 24, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28737858/the-effects-of-pneumococcal-conjugate-vaccine-pcv7-and-pcv13-on-turkish-children-with-invasive-pneumococcal-disease-a-single-center-experience
#8
Halil Özdemir, Caner Yıldız, Selin Nar Ötgün, Hatice Erkol, Adem Karbuz, Bilge Aldemir Kocabaş, Tuğçe Tural Kara, Ayşegül Gözalan, Rıza Durmaz, Ergin Çiftçi, Derya Aysev, Erdal İnce
INTRODUCTION: The aim of this prospective single-center study was to determine the changings in incidence of invasive pneumococcal disease (IPD), serotype distribution and the antimicrobial resistance patterns of S. pneumoniae in children with IPD after the period (1 to 7 years) of vaccination with PCV7 (2008) and PCV13 (2011). POPULATION AND METHODS: The study was conducted on 39 Turkish children with IPD between ages 1 month and 18 years in Ankara, Turkey. Streptococcus pneumoniae was identified using standard laboratory procedures from blood, cerebrospinal fluid (CSF), pleural fluid, and other sterile body fluids and tissues...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28715069/impact-of-diabetes-on-association-between-epicardial-fat-thickness-and-extent-and-complexity-of-coronary-artery-disease-in-patients-with-non-st-elevation-myocardial-infarction
#9
Taner Seker, Caner Turkoglu, Hazar Harbalıoglu, Mustafa Gur
BACKGROUND: Epicardial fat thickness (EFT) is associated with increased cardio metabolic risk. Recent studies have suggested that there is a strong relationship between diabetes and EFT. Although the relationship between EFT and coronary artery disease (CAD) is well known, the possible impact of diabetes on the relationship between EFT and extent and complexity of CAD was not fully investigated. AIM: We aimed to investigate the relationship between EFT and extent and complexity of CAD in patients with non-ST elevation myocardial infarction (NSTEMI) with and without diabetes...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28702761/can-a-hand-radiograph-indicate-a-special-diagnosis-in-a-child-with-chronic-kidney-disease-questions
#10
Eren Soyaltın, Belde Kasap-Demir, Caner Alparslan, Seçil Arslansoyu-Çamlar, Elif Perihan Öncel, Özgür Kırbıyık, Demet Alaygut, Önder Yavaşcan, Gamze Türe, Fatma Mutlubaş
No abstract text is available yet for this article.
July 12, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28699603/infants-with-extrahepatic-biliary-atresia-effect-of-follow-up-on-the-survival-rate-at-ege-university-medical-school-transplantation-center
#11
Miray Karakoyun, Maşallah Baran, Caner Turan, Murat Kılıç, Orkan Ergun, Sema Aydoğdu
BACKGROUND/AIMS: Biliary atresia (BA) is the main cause of neonatal cholestasis and the primary reason for infant liver transplants worldwide. It is an obliterative cholangiopathy observed only in children and caused by progressive inflammation and fibrosis of the bile duct. We collaborated with a liver transplantation center to investigate the effects of follow-up in patients with BA. MATERIALS AND METHODS: Medical records of 99 patients who were diagnosed with BA and monitored at our center from 1990 to 2002 (27 patients) and from 2003 to 2015 (72 patients) were analyzed retrospectively...
July 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28693363/prognostic-impact-of-incomplete-hematologic-count-recovery-and-minimal-residual-disease-on-outcome-in-adult-acute-lymphoblastic-leukemia-at-the-time-of-second-complete-response
#12
Caner Saygin, Nikolaos Papadantonakis, Ryan D Cassaday, Michaela Liedtke, Katrina Fischer, Tamara Dunn, Bhumika J Patel, Ronald Sobecks, Matt Kalaycio, Mikkael A Sekeres, Sudipto Mukherjee, Aaron T Gerds, Betty K Hamilton, Hetty E Carraway, Anjali S Advani
Outcomes of relapsed adult acute lymphoblastic leukemia (ALL) have improved over time with the introduction of new therapies as well as better supportive care. However, there is still a need for easy-to-use and accurate prognostic tools for patients in first relapse. Whether complete response (CR) with incomplete count recovery (CRh) can be grouped with CR in relapsed ALL trials has not been formally studied. We analyzed 106 ALL patients at first relapse who were treated at three academic centers and achieved CR/CRh...
July 11, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28674224/association-of-nfkb1a-and-micrornas-variations-and-the-susceptibility-to-atherosclerosis
#13
Tuba Oner, Caner Arslan, Guven Yenmis, Berk Arapi, Cigdem Tel, Birsen Aydemir, Gonul Kanigur Sultuybek
Atherosclerosis (AT) is a chronic immuno-inflammatory disease characterized by inflammatory mediators and immune activation in arterial wall. Although NF-κB and microRNAs are involved in the atherosclerotic lesions, the pathogenesis of atherosclerosis is still unknown. The aim of this study was to investigate the association of atherosclerosis with NFKB1-rs28362491, NFKBIA-rs696, pre-miRNA-146a-rs2910164 and pre-miRNA-499-rs3746444 polymorphisms as well as the analysis of their single and combined effects on its susceptibility in a Turkish population...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28660215/clinical-relevance-of-hla-antibodies-in-kidney-transplantation-recent-data-from-the-heidelberg-transplant-center-and-the-collaborative-transplant-study
#14
REVIEW
Caner Süsal, Alexander Fichtner, Burkhard Tönshoff, Arianeb Mehrabi, Martin Zeier, Christian Morath
Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum study, an algorithm was developed in 2006 for the transplantation of high-risk sensitized patients at the Heidelberg Transplant Center which includes seven different pre- and posttransplant measures. Using this algorithm, the number of transplantations could be increased in high-risk presensitized patients and the previously existing impact of antibodies on graft survival could greatly be diminished but not totally eliminated...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28642671/subchondral-raft-construction-with-locking-plates-for-the-treatment-of-schatzker-type-ii-fractures
#15
Cemil Kayali, Caner Citak, Taskin Altay, Zafer Kement
OBJECTIVES: To evaluate the functional and radiological results of Schatzker type II fractures treated via subchondral raft screws combined with locking plates. METHODS: Twenty-four individuals were enrolled in this study between 2010 and 2014. The depressed joint line was elevated and the defect was filled with allograft. Next, two or three subchondral screws were placed in combination with a locking plate. At the last follow-up, clinical and radiological data were recorded...
May 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28638683/low-prevalence-of-obesity-in-beh%C3%A3-et-s-disease-is-associated-with-high-obestatin-level
#16
Süleyman Serdar Koca, Murat Kara, Metin Özgen, Ramazan Dayanan, Caner Feyzi Demir, Kader Aksoy, Nevin İlhan, Emir Dönder, Ahmet Işık
OBJECTIVE: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). MATERIAL AND METHODS: One hundred and forty-three (143) patients with BD and 112 healthy controls (HC) were enrolled. Participants were subdivided according to the body mass index (BMI) as lean (<18...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28634174/prognostic-value-of-uric-acid-for-pulmonary-thromboembolism
#17
Savas Ozsu, Arif M Çoşar, Hayriye Bektas Aksoy, Yilmaz Bülbül, Funda Oztuna, S Caner Karahan, Tevfik Ozlu
BACKGROUND: Pulmonary thromboembolism is a serious cardiovascular condition with considerable morbidity and mortality. Clinical studies have indicated that hyperuricemia is an independent risk factor for cardiovascular events. The aim of this study was to investigate possible value of the serum levels of uric acid (UA) in predicting 30-d pulmonary thromboembolism-related mortality. METHODS: Pulmonary thromboembolism was confirmed by computed tomography pulmonary angiography, demographic data, troponin, systolic pressure and pulse on admission, and simplified pulmonary embolism severity index assessment...
August 2017: Respiratory Care
https://www.readbyqxmd.com/read/28628220/importance-of-endothelial-dysfunction-biomarkers-in-patients-with-crimean-congo-hemorrhagic-fever
#18
Mustafa Arslan, Gürdal Yilmaz, Ahmet Mentese, Hülya Yilmaz, S Caner Karahan, Iftihar Koksal
BACKGROUND: The pathogenesis of the Crimean-Congo hemorrhagic fever (CCHF) and the cause of the hemorrhage are not yet fully understood. However, the endothelium plays a key role in the pathogenesis. The purpose of this study was to investigate endothelial dysfunction markers [asymmetrical dimethyl arginine(ADMA), endothelin 1(ET-1), thrombomodulin(TM), von Willebrand factor(vWf) and intercellular adhesion molecule(ICAM-1)] in serum in patients with CCHF and their associations with hemorrhage...
June 19, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28618755/isolation-rates-and-antibiotic-susceptibilities-of-different-enterobacteriaceae-species-as-urinary-tract-infection-agents-in-turkey-a-systematic-review
#19
Caner Yürüyen, Yeşim Gürol, Sabire Ferda Kaleağasioğlu, Elif Çiğdem Kaspar, Gülden Yilmaz
BACKGROUND/AIM: In Turkey, few systematic reviews have analyzed the results of studies on the isolation rates of urinary tract infection agents and their antibiotic susceptibilities. This review was done to fill this gap and enable the correct application of guideline-based medical therapy by determining the isolation rates and antibiotic susceptibilities of different Enterobacteriaceae species in Turkey. MATERIALS AND METHODS: Relevant studies found from various databases with the help of previously specified search strategies were examined and eliminated according to eligibility criteria...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618740/screening-of-immunocompromised-patients-at-risk-of-strongyloidiasis-in-western-turkey-using-elisa-and-real-time-pcr
#20
Esra Erdem Kivrak, Esra Atalay Şahar, Hüseyin Can, Mert Döşkaya, Mümtaz Yilmaz, Hüsnü Pullukçu, Ayşe Caner, Hüseyin Töz, Adnan Yüksel Gürüz, Meltem Işikgöz Taşbakan
BACKGROUND/AIM: Strongyloides stercoralis causes life-threatening hyperinfection or disseminated strongyloidiasis in immunocompromised patients such as HIV-positive, organ transplantation, and cancer patients. This study investigated the presence of strongyloidiasis in immunocompromised patients for the first time in Turkey. MATERIALS AND METHODS: Serum and stool samples were collected from 108 patients (25.9% of them were chronic renal failure and 74.1% were renal transplantation patients) who were admitted to Ege University Medical School in İzmir, located in western Turkey...
June 12, 2017: Turkish Journal of Medical Sciences
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