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https://www.readbyqxmd.com/read/28510771/inability-of-open-field-autorefraction-to-eliminate-accommodation-in-preschoolers
#1
Caner Kara, İkbal Seza Petriçli
PURPOSE: To evaluate the effectiveness of the Shin-Nippon NVision-K 5001 autorefractometer (Rexxam Co. Ltd., Osaka, Japan) (also branded as the Grand Seiko WR-5100K; Grand Seiko Co. Ltd., Hiroshima, Japan) based on the open-field refractometry principle in refractive measurements of preschool children and to determine its ability to eliminate accommodation adequately. METHODS: The refractive results of 114 preschool children who presented to the ophthalmology outpatient department for screening were evaluated...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28471872/hla-matching-in-pediatric-kidney-transplantation-hla-poorly-matched-living-donor-transplants-versus-hla-well-matched-deceased-donor-transplants
#2
Gerhard Opelz, Bernd Döhler, Derek Middleton, Caner Süsal
BACKGROUND: Based on an analysis of 542 pediatric kidney transplants recorded by the UK Transplant Registry from 2000-2012, it was concluded that the survival rate of HLA poorly matched living donor transplants is not inferior to that of HLA well matched deceased donor transplants. METHODS: We analyzed the impact of HLA matching on kidney graft survival in 3627 pediatric living donor transplants performed during 2000-2015 using the data of the Collaborative Transplant Study...
May 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28464572/-consensus-of-prostate-cancer-screening
#3
(no author information available yet)
The incidence of prostate cancer is increasing rapidly in China, the clinical stage of prostate cancer patients is comparatively late and the overall survival rate is inferior to that reported in the developed countries. Prostate cancer screening is an effective measure to reduce the risk of death through early detection. In order to identify the best way of prostate cancer screening in China, the Chinese Anti-Cancer Association Genitourinary Cancer Committee Prostate Cancer Working Group reviewed all published data concerning the benefits and harms of screening for prostate caner and created the consensus...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28460546/an-update-on-chemical-pharmacotherapy-options-for-the-prevention-of-kidney-transplant-rejection-with-a-focus-on-costimulation-blockade
#4
Florian Kälble, Matthias Schaier, Sebastian Schäfer, Caner Süsal, Martin Zeier, Claudia Sommerer, Christian Morath
The introduction of calcineurin inhibitors (CNI) has greatly improved graft survival in the past three decades. However, long-term graft survival is still limited due to chronic allograft injury and side-effects of immunosuppressive medication. Areas covered: The present overview gives an update on pharmacotherapeutic strategies after kidney transplantation. The main focus is on CNI-sparing regimens using co-stimulatory blockade and on new substances on the horizone. Expert opinion: CNI sparing regimens are well-established...
May 9, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28459374/long-noncoding-nature-brain-derived-neurotrophic-factor-antisense-is-associated-with-poor-prognosis-and-functional-regulation-in-non-small-cell-lung-caner
#5
MingJing Shen, Zhonghua Xu, Kanqiu Jiang, Weihua Xu, Yongbin Chen, ZhongHeng Xu
In this study, we evaluated the prognostic potential and functional regulation of human nature antisense, brain-derived neurotrophic factor antisense, in non-small cell lung cancer. Non-small cell lung cancer carcinoma and adjacent non-carcinoma lung tissues were extracted from 151 patients. Their endogenous brain-derived neurotrophic factor antisense expression levels were compared by quantitative reverse transcription polymerase chain reaction. Clinical relevance between endogenous brain-derived neurotrophic factor antisense expression level and patients' clinicopathological variances or overall survival was analyzed...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28455966/arginine-deiminase-expressed-in-vivo-driven-by-human-telomerase-reverse-transcriptase-promoter-displays-high-hepatoma-targeting-and-oncolytic-efficiency
#6
Hui Jiang, Song Guo, Dan Xiao, Xuzhao Bian, Jie Wang, Ying Wang, Huiting Zhou, Jun Cai, Zhongliang Zheng
Arginine starvation has the potential to selectively treat both primary tumor and (micro) metastatic tissue with very low side effects. Arginine deiminase (ADI; EC 3.5.3.6), an arginine-degrading enzyme, has been studied as a potential anti-tumor drug for the treatment of arginine-auxotrophic tumors. Though ADI-PEG20 (pegylated ADI by PEG 20,000) already passed the phase I/II clinical trials [1], it is just used as adjuvant therapy because of its low efficiency and less targeting. Then, this paper discussed the efficiency of arginine starvation mediated by ADI expressed in cytoplasm for liver cancers...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28450958/upregulation-of-olr1-and-il17a-genes-and-their-association-with-blood-glucose-and-lipid-levels-in-femoropopliteal-artery-disease
#7
Caner Arslan, Burcu Bayoglu, Cigdem Tel, Mujgan Cengiz, Ahmet Dirican, Kazim Besirli
Oxidized low-density lipoprotein receptor 1 (OLR1) and interleukin 17A (IL17A) have pro-inflammatory roles in the development of cardiovascular disorders. The present study evaluated the association of OLR1 and IL17A and their polymorphisms with the development of femoropopliteal (FP) artery disease. The mRNA expression of OLR1 and IL17A in peripheral blood mononuclear cells as well as the frequency of OLR1 rs11053646 and IL17A rs8193037 and rs3819025 polymorphisms were assessed by polymerase chain reaction in 70 patients with FP artery disease and 80 age-matched disease-free controls...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28420416/emerging-therapies-for-acute-myeloid-leukemia
#8
REVIEW
Caner Saygin, Hetty E Carraway
Acute myeloid leukemia (AML) is characterized by clinical and biological heterogeneity. Despite the advances in our understanding of its pathobiology, the chemotherapy-directed management has remained largely unchanged in the past 40 years. However, various novel agents have demonstrated clinical activity, either as single agents (e.g., isocitrate dehydrogenase (IDH) inhibitors, vadastuximab) or in combination with standard induction/consolidation at diagnosis and with salvage regimens at relapse. The classes of agents described in this review include novel cytotoxic chemotherapies (CPX-351 and vosaroxin), epigenetic modifiers (guadecitabine, IDH inhibitors, histone deacetylase (HDAC) inhibitors, bromodomain and extraterminal (BET) inhibitors), FMS-like tyrosine kinase receptor 3 (FLT3) inhibitors, and antibody-drug conjugates (vadastuximab), as well as cell cycle inhibitors (volasertib), B-cell lymphoma 2 (BCL-2) inhibitors, and aminopeptidase inhibitors...
April 18, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28396941/effect-of-the-timing-of-dialysis-initiation-on-left-ventricular-hypertrophy-and-%C3%A4-nflammation-in-pediatric-patients
#9
Sevcan A Bakkaloğlu, Yaşar Kandur, Erkin Serdaroğlu, Aytül Noyan, Aysun Karabay Bayazıt, Lale Sever, Sare Gülfem Özlü, Gül Özçelik, İsmail Dursun, Caner Alparslan
BACKGROUND: The optimal time for dialysis initiation in adults and children with chronic kidney disease remains unclear. The aim of this study was to evaluate the impact of dialysis timing on different outcome parameters, in particular left ventricular (LV) morphology and inflammation, in pediatric patients receiving peritoneal dialysis and hemodialysis. METHODS: The medical records of pediatric dialysis patients who were followed-up in nine pediatric nephrology centers in Turkey between 2008 and 2013 were retrospectively reviewed...
April 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28391099/re-establishment-of-hummock-topography-promotes-tree-regeneration-on-highly-disturbed-moderate-rich-fens
#10
Victor J Lieffers, Richard T Caners, Hangfei Ge
Winter exploration of oil sands deposits underlying wooded fens mostly eliminates the hummock-hollow topography on drilling pads and the ice roads leading to them, after their abandonment in spring. Recovery of black spruce (Picea mariana (P. Mill.) B.S.P.) and tamarack (Larix laricina (Du Roi) K. Koch) on these disturbed peatlands is thought to depend on the recovery of hummock topography. In late winter, numerous large blocks of frozen peat (1.5 × 1.5 m) were lifted out of the flattened drilling pads and positioned beside their excavated hollows; this was done on six temporary pads...
April 6, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28390112/knockdown-of-rap2b-a-ras-superfamily-protein-inhibits-proliferation-migration-and-invasion-in-cervical-cancer-cells-via-regulating-the-erk1-2-signaling-pathway
#11
Yinghua Li, Songyi Li, Lili Huang
Rap2B, belonging to the Ras superfamily, has been demonstrated to be implicated in caner development and function as atumor promoter. However, the role of Rap2B in cervical cancer is unknown. In this study, we investigated the expression pattern and biological functions of Rap2B in cervical cancer. The results showed that Rap2B was overexpressed in cervical cancer tissues and cell lines. Knockdown of Rap2B inhibited the proliferation, migration and invasion of cervical cancer cells. In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo...
April 3, 2017: Oncology Research
https://www.readbyqxmd.com/read/28387173/pure-red-cell-aplasia-due-to-parvovirus-b19-erythropoietin-resistant-anemia-in-a-pediatric-kidney-recipient
#12
Baris Malbora, Serdar Saritas, Eda Ataseven, Burcu Belen, Caner Alparslan, Onder Yavascan, Dilek Yilmaz Ciftdogan, Berna Atabay, Meral Turker
No abstract text is available yet for this article.
April 6, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28367098/small-role-with-big-impact-mirnas-as-communicators-in-the-cross-talk-between-cancer-associated-fibroblasts-and-cancer-cells
#13
REVIEW
Zhanhuai Wang, Yinuo Tan, Wei Yu, Shu Zheng, Suzhan Zhang, Lifeng Sun, Kefeng Ding
Cancer microenvironment is composed of numerous components that can support cancer cell proliferation, promote cancer progression and contribute to cancer treatment resistance. The major components of caner microenvironment are fibroblasts, endothelial cells, immune cells as well as cytokines, chemokines, and extracellular matrix (ECM) all of which surround tumor cells as the core and cross talk with each other. Among them, cancer-associated fibroblasts (CAFs) play an important role in promoting cancer progression by secreting various pro-inflammatory factors...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28360806/possible-effects-of-copper-and-ceruloplasmin-levels-on-auditory-event-potentials-in-boys-with-attention-deficit-hyperactivity-disorder
#14
Özgür Yorbik, Caner Mutlu, Mehmet Fatih Özdağ, Abdullah Olgun, Gül Eryilmaz, Semih Ayta
INTRODUCTION: The aims of the present study were to investigate the relationship between levels of plasma copper (Cu) and ceruloplasmin (Cp) and amplitudes and latencies of P1, N2, and P3 in the parietal and frontal areas of children with attention deficit hyperactivity disorder (ADHD) as well as to compare these Cu levels and event-related potentials (ERPs) indices in controls. METHODS: Boys (n=41) with ADHD were divided into two subgroups according to a median split of plasma Cu and Cp levels, separately...
December 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28332057/the-impact-of-operative-approach-on-postoperative-complications-following-colectomy-for-colon-caner
#15
Benedetto Mungo, Christina M Papageorge, Miloslawa Stem, Daniela Molena, Anne O Lidor
BACKGROUND: Colectomy is one of the most common major abdominal procedures performed in the USA. A better understanding of risk factors and the effect of operative approach on adverse postoperative outcomes may significantly improve quality of care. METHODS: Adult patients with a primary diagnosis of colon cancer undergoing colectomy were selected from the National Surgical Quality Improvement Program 2013-2015 targeted colectomy database. Patients were stratified into five groups based on specific operative approach...
March 22, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28327615/neoadjuvant-chemotherapy-creates-surgery-opportunities-for-inoperable-locally-advanced-breast-cancer
#16
Minghao Wang, Lingmi Hou, Maoshan Chen, Yan Zhou, Yueyang Liang, Shushu Wang, Jun Jiang, Yi Zhang
Neoadjuvant chemotherapy (NAC), the systematic chemotherapy given to patients with locally advanced and inoperable breast caner, has been proven to be of great clinical values. Many scientific reports confirmed NAC could effectively eliminate sub-clinical disseminated lesions of tumor, and improve long-term and disease-free survival rate of patients with locally advanced breast cancer (LABC); however, up to now, LABC is still a serious clinical issue given improved screening and early diagnosis. This study, with main focus on inoperable LABC, investigated the values of NAC in converting inoperable LABC into operable status and assessed the prognosis...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321223/abo-incompatible-kidney-transplantation
#17
REVIEW
Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal
ABO-incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rates in compatible transplantations. Desensitization is usually achieved by apheresis and B cell-depleting therapies that are accompanied by powerful immunosuppression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28318368/the-wayward-methyl-group-and-the-cascade-to-cancer
#18
Robert M Hoffman
We propose here a hypothesis of the cause of cancer that brings together fundamental changes in methyl-group metabolism resulting in methionine dependence and global DNA hypomethylation which destabilizes the genome leading to aneuploid karyotypes which evolve and stabilize into autonomous cancer. Experimental support for this hypothesis is that methioine dependence is a general metabolic defect in caner. Methionine dependence is due to excess use of methionene for aberrant transmethylation reactions that apparently divert methyl groups from DNA...
May 3, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28315566/directly-ventricular-septal-defect-closure-without-using-arteriovenous-wire-loop-our-adult-case-series-using-transarterial-retrograde-approach
#19
Nihat Pekel, Ertuğrul Ercan, Mehmet Emre Özpelit, Ferhat Özyurtlu, Akar Yılmaz, Caner Topaloğlu, Serkan Saygı, Serkan Yakan, İstemihan Tengiz
OBJECTIVE: The standard transcatheter ventricular septal defects (VSD) closure procedure is established with arteriovenous (AV) loop and is called as antegrade approach. The directly retrograde transarterial VSD closure without using AV loop might be better option as shortens the procedure time and decreases radiation exposure. METHODS: Our series consist of twelve sequential adult cases with congenital VSDs (seven with perimembranous, four with muscular, one with postoperative residuel VSD)...
February 21, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28304276/scaffold-mediated-gating-of-cdc42-signalling-flux
#20
Péter Rapali, Romain Mitteau, Craig Braun, Aurèlie Massoni-Laporte, Caner Ünlü, Laure Bataille, Floriane Saint Arramon, Steven P Gygi, Derek McCusker
Scaffold proteins modulate signalling pathway activity spatially and temporally. In budding yeast, the scaffold Bem1 contributes to polarity axis establishment by regulating the GTPase Cdc42. Although different models have been proposed for Bem1 function, there is little direct evidence for an underlying mechanism. Here, we find that Bem1 directly augments the guanine exchange factor (GEF) activity of Cdc24. Bem1 also increases GEF phosphorylation by the p21-activated kinase (PAK), Cla4. Phosphorylation abrogates the scaffold-dependent stimulation of GEF activity, rendering Cdc24 insensitive to additional Bem1...
March 17, 2017: ELife
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