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https://www.readbyqxmd.com/read/29125816/intraobserver-and-interobserver-reliability-assessment-of-tibial-plateau-fracture-classification-systems
#1
Anıl Taşkesen, İsmail Demirkale, Mustafa Caner Okkaoğlu, Mahmut Özdemir, Mustafa Gökhan Bilgili, Murat Altay
OBJECTIVES: This study aims to assess the intra- and interobserver reliability of commonly used tibial plateau fracture classification systems. PATIENTS AND METHODS: This retrospective cohort study included computed tomography (CT) and plain radiographic images (lateral and anteroposterior X-rays) of 60 patients (40 males, 20 females; mean age 45.9 years; range 18 to 80 years) who presented to two orthopaedic clinics between January 2011 and January 2015 with unilateral tibial plateau fractures...
December 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/29111444/toxicity-assessment-of-pesticide-triclosan-by-aquatic-organisms-and-degradation-studies
#2
Burcu Ertit Taştan, Turgay Tekinay, Hatice Sena Çelik, Caner Özdemir, Dilara Nur Cakir
Triclosan is considered as an important contaminant and is widely used in personal care products as an antimicrobial agent. This study demonstrates the biodegradation of triclosan by two freshwater microalgae and the acute toxicity of triclosan and 2,4-dichlorophenol. The effects of culture media and light on biodegradation of triclosan and the changing morphology of microalgae were systematically studied. Geitlerinema sp. and Chlorella sp. degraded 82.10% and 92.83% of 3.99 mg/L of triclosan at 10 days, respectively...
October 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29080848/assessment-of-novel-tobacco-heating-product-thp1-0-part-3-comprehensive-chemical-characterisation-of-harmful-and-potentially-harmful-aerosol-emissions
#3
Mark Forster, Stacy Fiebelkorn, Caner Yurteri, Derek Mariner, Chuan Liu, Christopher Wright, Kevin McAdam, James Murphy, Christopher Proctor
For a tobacco heating product (THP), which heats rather than burns tobacco, the emissions of toxicants in the aerosol were compared with those in cigarette smoke under a machine-puffing regimen of puff volume 55 ml, puff duration 2 s and puff interval 30 s. The list of toxicants included those proposed by Health Canada, the World Health Organization Study Group on Tobacco Product Regulation (TobReg), the US Food and Drug Administration and possible thermal breakdown products. In comparison to the University of Kentucky 3R4F reference cigarette the toxicant levels in the THP1...
October 25, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29059337/understanding-personal-risk-of-oropharyngeal-cancer-risk-groups-for-oncogenic-oral-hpv-infection-and-oropharyngeal-cancer
#4
G D'Souza, T S McNeel, C Fakhry
Background: Incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing. There is interest in identifying healthy individuals most at risk for development of oropharyngeal cancer to inform screening strategies. Patients and methods: All data are from 2009 to 2014, including 13 089 people ages 20-69 in the National Health and Nutrition Examination Survey (NHANES), oropharyngeal cancer cases from the Surveillance, Epidemiology, and End Results (SEER 18) registries (representing ∼28% of the US population), and oropharyngeal cancer mortality from National Center for Health Statistics (NCHS)...
October 19, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29054721/characterizing-the-association-between-toll-like-receptor-subtypes-and-nephrolithiasis-with-renal-inflammation-in-an-animal-model
#5
Mahmut Taha Olcucu, Kerem Teke, Serdar Yalcin, Erkan Olcucuoglu, Vildan Caner, Nilay Sen Turk, Omer Levent Tuncay
OBJECTIVES: To show experimentally induced renal stone disease and evaluate secondary inflammatory responses in vivo, and to characterize changes in expression of Toll-like receptor (TLR) subtypes in this model. To evaluate the associations of hyperoxaluria-induced renal stone formation and Toll-like receptors (TLRs) expression in a rat inflammation model. METHODS: Twenty 5-6-week-old male Wistar rats were divided into control and hyperoxaluria groups (n=10/group) and supplied with normal water or 1% ethylene glycol, respectively, for 16 weeks...
October 17, 2017: Urology
https://www.readbyqxmd.com/read/29045966/-immune-effects-of-specific-ctls-response-induced-by-dendritic-cells-pulsed-with-ny-eso-1-peptide
#6
J W Liu, X Lu, Z M Yang, L J Deng, L Yang
OBJECTIVE: To explore the potential of autologous dendritic cells (DCs) pulsed with caner/testis antigen NY-ESO-1 peptides in inducing specific cytotoxic T lymphocyte (CTLs) response and antineoplastic immune function of specific CTLs. METHODS: Fifteen patients with II to III stage positive HLA -A0201(+) and NY-ESO-1(+) were enrolled in the Cancer Hospital Chinese Academy of Medical Sciences on the basis of preclinical experiments from November 2014 to October 2015, and their peripheral blood mononuclear cells (PBMCs) and peripheral blood lymphocytes (PBLs) were isolated...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29037581/pulmonary-embolism-due-to-exogenous-estrogen-intoxication
#7
Caner Çelik, Murat Carus, Fatih Büyükcam
OBJECTIVE: Pulmonary embolism is a relatively common clinical presentation of venous thromboembolism, which develops in relation to acute pulmonary arterial occlusion mostly caused by thrombi of the lower limbs. CASE REPORT: 29year old female admitted to emergency department with pulmonary thromboembolism due to an ingestion of 17 Diana 35 pills (2 mg cyproterone acetate and 0.035mg ethinyl estradiol) in a suicide attempt without any previously known predisposing factors...
August 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28994198/the-incidence-of-thyroid-cartilage-invasion-in-early-stage-laryngeal-carcinoma-our-experience-on-sixty-two-patients
#8
LETTER
H M Yener, M Yilmaz, A B Karaaltın, H C Inan, F Turgut, E D Gözen, N Comunoglu, E Karaman
No abstract text is available yet for this article.
October 10, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28981408/multi-instance-multi-label-learning-for-multi-class-classification-of-whole-slide-breast-histopathology-images
#9
Caner Mercan, Selim Aksoy, Ezgi Mercan, Linda G Shapiro, Donald L Weaver, Joann G Elmore
Digital pathology has entered a new era with the availability of whole slide scanners that create high-resolution images of full biopsy slides. Consequently, the uncertainty regarding the correspondence between the image areas and the diagnostic labels assigned by pathologists at the slide level, and the need for identifying regions that belong to multiple classes with different clinical significance have emerged as two new challenges. However, generalizability of the state-of-theart algorithms, whose accuracies were reported on carefully selected regions of interest (ROI) for the binary benign versus cancer classification, to these multi-class learning and localization problems is currently unknown...
October 2, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28972300/photocatalytic-transfer-hydrogenolysis-of-allylic-alcohols-on-pd-tio2-a-shortcut-to-s-lavandulol
#10
Susumu Saito, Yuki Takada, Joaquim Caner, Selvam Kaliyamoorthy, Hiroshi Naka
We report herein a regio- and stereoselective photocatalytic hydrogenolysis of allylic alcohols to form unsaturated hydrocarbons employing a palladium(II)-loaded titanium oxide; the reaction proceeds at room temperature under light irradiation without stoichiometric generation of salt wastes. Olefin and saturated alcohol moieties tolerated the reaction conditions. Hydrogen atoms were selectively incorporated into less sterically congested carbons of the allylic functionalities. This protocol allowed a short-step synthesis of (S)-(+)-lavandulol from (R)-(-)-carvone by avoiding otherwise necessary protection/deprotection steps...
October 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28956482/effects-of-arginine-and-trehalose-on-post-thawed-bovine-sperm-quality
#11
Caner Öztürk, Şükrü Güngör, Mehmet Bozkurt Ataman, Mustafa Numan Bucak, Nuri Başpinar, Pınar Ili, Muhammed Enes Inanç
The present study was conducted to examine the protective role of arginine and trehalose on post-thaw bull sperm and oxidative stress parameters. Five ejaculates for each bull were used in the study. Each ejaculate, split into three equal aliquots and diluted at 37 °C with base extenders containing 2 mM arginine, 25 mM trehalose and no antioxidant (control) was cooled to 5 °C and then frozen. Frozen straws were thawed in a water bath for evaluation. Supplementation of the semen extender with arginine decreased the percentages of post-thawed subjective motility (29 ± 8...
September 2017: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/28956255/multiple-presentations-of-lrba-deficiency-a-single-center-experience
#12
Sevgi Kostel Bal, Sule Haskologlu, Nina K Serwas, Candan Islamoglu, Caner Aytekin, Tanil Kendirli, Zarife Kuloglu, Gulsan Yavuz, Buket Dalgic, Zeynep Siklar, Aydan Kansu, Arzu Ensari, Kaan Boztug, Figen Dogu, Aydan Ikinciogullari
INTRODUCTION: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency categorized as common variable immunodeficiency associated with autoimmune manifestations and inflammatory bowel diseases; however, the clinical spectrum has been extended. Here, we present our cohort of Turkish LRBA-deficient patients from a single center, demonstrating a diversity of clinical manifestations. METHOD: Seven affected individuals from five families were assessed retrospectively in this study...
November 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28938537/mir-590-3p-promotes-proliferation-and-metastasis-of-colorectal-cancer-via-hippo-pathway
#13
Zhen-Qiang Sun, Ke Shi, Quan-Bo Zhou, Xiang-Yue Zeng, Jinbo Liu, Shuai-Xi Yang, Qi-San Wang, Zhen Li, Gui-Xian Wang, Jun-Min Song, Wei-Tang Yuan, Hai-Jiang Wang
Studies reported that miR-590-3p was involved in human cancer progression. However, its roles of oncogene or anti-oncogene in malignancies still remain elusive. This study was aimed to investigate the effect of miR-590-3p on the cell proliferation and metastasis via Hippo pathway in colorectal cancer (CRC). In our study, miR-590-3p was demonstrated highly expressed in CRC tissues, compared with adjacent normal tissues (P<0.05). In addition, miR-590-3p was positively associated with TNM stage and distant metastasis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935428/predictive-factors-for-the-outcome-of-high-flow-nasal-cannula-therapy-in-a-pediatric-intensive-care-unit-is-the-spo2-fio2-ratio-useful
#14
Fulya Kamit Can, Ayşe Berna Anil, Murat Anil, Neslihan Zengin, Fatih Durak, Caner Alparslan, Zeynep Goc
OBJECTIVES: To determine the predictive factors for the outcome of high-flow nasal cannula (HFNC) therapy in a pediatric intensive care unit (PICU). MATERIALS AND METHODS: We prospectively included all patients with acute respiratory distress/failure aged 1month to 18years who were admitted to the PICU between January 2015 and May 2016 and treated with HFNC as a primary support and for postextubation according to our pre-established protocol. HFNC failure was defined as the need for escalation to non-invasive ventilation (NIV) or invasive mechanical ventilation (MV)...
September 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28933054/high-stmn1-expression-is-associated-with-cancer-progression-and-chemo-resistance-in-lung-squamous-cell-carcinoma
#15
Pinjie Bao, Takehiko Yokobori, Bolag Altan, Misaki Iijima, Youko Azuma, Ryoichi Onozato, Toshiki Yajima, Akira Watanabe, Akira Mogi, Kimihiro Shimizu, Toshiteru Nagashima, Yoichi Ohtaki, Kai Obayashi, Seshiru Nakazawa, Tuya Bai, Reika Kawabata-Iwakawa, Takayuki Asao, Kyoichi Kaira, Masahiko Nishiyama, Hiroyuki Kuwano
BACKGROUND: Known as a microtubule-destabilizing protein, STMN1 (gene symbol: STMN1) regulates the dynamics of microtubules, cell cycle progress, and chemo-resistance against taxane agents. It is highly expressed in various human cancers and involved in cancer progression as well as poor prognosis. METHODS: Expression of STMN1 was examined by immunohistochemistry using FFPE tissue sections from 186 patients with lung squamous cell carcinoma (LSCC). Analysis of STMN1 suppression was performed for STMN1 small interfering RNA (siRNA)-transfected LSCC cell lines to determine the change in proliferation, invasive and apoptosis abilities, and paclitaxel sensitivity...
September 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28928129/new-advances-and-challenges-of-targeting-cancer-stem-cells
#16
Nurmaa K Dashzeveg, Rokana Taftaf, Erika K Ramos, Luke Torre-Healy, Anastasia Chumakova, Daniel J Silver, Tyler J Alban, Maksim Sinyuk, Praveena S Thiagarajan, Awad M Jarrar, Soumya M Turaga, Caner Saygin, Erin Mulkearns-Hubert, Masahiro Hitomi, Jeremy N Rich, Stanton L Gerson, Justin D Lathia, Huiping Liu
The second International Cancer Stem Cell Conference in Cleveland, Ohio, on September 20-23, 2016, convened 330 attendees from academic, industrial, and clinical organizations. It featured a debate on the concepts and challenges of the cancer stem cells (CSC) as well as CSC-centered scientific sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression, metastasis, therapeutic resistance, and emerging novel concepts. The conference hosted 35 renowned speakers, 100 posters, 20 short talks, and a preconference workshop...
October 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28925558/endothelial-precursor-cell-cross-match-using-tie-2-enriched-spleen-cells
#17
Volker Daniel, Caner Süsal, Sabine Scherer, Hien Tran, Petra Gombos, Karina Trojan, Mahmoud Sadeghi, Christian Morath, Gerhard Opelz
BACKGROUND: Non-HLA antibodies against human endothelial progenitor cells (EPC) in pre-transplant recipient serum can have a deleterious influence on the graft. EPC enriched from peripheral blood have been commonly used for EPC cross-matching. In the present study, we describe cross-matches using EPC enriched from fresh or frozen-thawed spleen cell preparations, thereby widening the sample source for deceased-donor cross-matching and retrospective studies. METHODS: EPC cross-matches were performed retrospectively using spleen cells and the flow cytometric XM-ONE cross-match test kit...
September 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28885437/cellular-angiofibroma-of-the-nasopharynx
#18
Zülküf Burak Erdur, Haydar Murat Yener, Mehmet Yilmaz, Ayşegül Batioğlu Karaaltin, Hakki Caner Inan, Elvin Alaskarov, Emine Deniz Gozen
Angiofibroma is a common tumor of the nasopharynx region but cellular type is extremely rare in head and neck. A 13-year-old boy presented with frequent epistaxis and nasal obstruction persisting for 6 months. According to the clinical symptoms and imaging studies juvenile angiofibroma was suspected. Following angiographic embolization total excision of the lesion by midfacial degloving approach was performed. Histological examination revealed that the tumor consisted of staghorn blood vessels and irregular fibrous stroma...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28883432/quantitative-phosphoproteomic-analysis-reveals-key-mechanisms-of-cellular-proliferation-in-liver-cancer-cells
#19
Bo Zhu, Quanze He, Jingjing Xiang, Fang Qi, Hao Cai, Jun Mao, Chunhua Zhang, Qin Zhang, Haibo Li, Lu Lu, Ting Wang, Wenbo Yu
Understanding the mechanisms of uncontrolled proliferation in cancer cells provides valuable insights into tumor development and is benefit for discovering efficient methods in cancer treatment. In this study, we identified and quantified 2,057 phosphoproteins and 9,824 unique phosphosites in three liver cell lines with high (QGY, Hep3B) and low (L02) proliferative potentials and disclosed the wide variations in phosphorylation sites and levels among them. We found that the number of identified phosphoproteins and phosphosites in these cells were negatively correlated with their proliferative abilities...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857997/cervical-necrotizing-fasciitis-of-odontogenic-origin-and-hyperbaric-oxygen-therapy
#20
Caner Hakki Inan, Haydar Murat Yener, Mehmet Yilmaz, Emine Deniz Gözen, Zülküf Burak Erdur, Bengüsu Oroğlu, Eren Olcay, Nermin Memmedova
Necrotizing fasciitis (NF) is an infection of the soft tissues pathology with high mortality that spreads through the fascial planes and rarely seen in head and neck region. The cause of infection is often odontogenic problems. Broad-spectrum antibiotics, surgical debridement, and hyperbaric oxygen therapy (HBO) are important for the treatment of disease. We report a case of cervical NF in a 33-year-old woman who was treated with rapid surgical debridement and simultaneous HBO.
October 2017: Journal of Craniofacial Surgery
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