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Premature thelarche

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https://www.readbyqxmd.com/read/27191050/central-precocious-puberty-revisiting-the-diagnosis-and-therapeutic-management
#1
Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior
Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemical parameters, and a period of follow-up is desirable to define the "progressive" form of sexual precocity. This occurs due to the broad spectrum of pubertal development, including isolated premature thelarche, constitutional growth and puberty acceleration, progressive and nonprogressive CPP, and early puberty...
April 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27035145/serum-levels-of-polybrominated-diphenyl-ethers-in-girls-with-premature-thelarche
#2
Annalisa Deodati, Alessia Sallemi, Francesca Maranghi, Daniela Germani, Antonella Puglianiello, Francesca Baldari, Luca Busani, Francesca Romana Mancini, Roberta Tassinari, Alberto Mantovani, Stefano Cianfarani
BACKGROUND/AIMS: Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have shown endocrine disruption properties in experimental studies. The aim of this study was to investigate the association between the exposure to PBDEs and alterations of puberty in girls referred for idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: A case-control study was conducted in 124 girls: 37 girls with ICPP (mean age 7.4 ± 0...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/26909102/increasing-incidence-of-premature-thelarche-in-the-central-region-of-denmark-challenges-in-differentiating-girls-less-than-7%C3%A2-years-of-age-with-premature-thelarche-from-girls-with-precocious-puberty-in-real-life-practice
#3
Mia Elbek Sømod, Esben Thyssen Vestergaard, Kurt Kristensen, Niels Holtum Birkebæk
BACKGROUND: Premature thelarche (PT) seems to be increasing and it is difficult to differentiate its early stages from precocious puberty (PP). Clinical and biochemical parameters are warranted to differentiate the two diagnoses. METHODS: One hundred ninety-one girls aged 0.5-7 years were included. Diagnoses were validated and the girls were categorized to the groups PP (n = 27) and PT (n = 164). Anthropometry, Tanner stages, ethnicity, bone age, and biochemistry, were recorded...
2016: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/26831552/plasma-kisspeptin-levels-in-newborn-infants-with-breast-enlargement
#4
Avni Kaya, Zerrin Orbak, Harun Polat, Atilla Çayır, Abdullah Erdil, Hakan Döneray
OBJECTIVE: Kisspeptin levels have been reported in children with premature thelarche, precocious puberty and adolescent gynecomastia, but there are no reports on kisspeptin levels in the neonatal period. This study aimed to investigate plasma kisspeptin hormone levels in newborns with and without breast enlargement. METHODS: Plasma kisspeptin levels and other related biochemical variables were investigated in this prospective study conducted on 40 (20 girls and 20 boys) newborn infants with breast enlargement and on 40 healthy control infants (20 girls and 20 boys)...
September 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26388894/usefulness-of-pelvic-ultrasonography-for-the-diagnosis-of-central-precocious-puberty-in-girls
#5
Jung Yu, Ha Young Shin, Sun Hee Lee, You Sung Kim, Jae Hyun Kim
PURPOSE: It is difficult to differentiate between central precocious puberty (CPP) and premature thelarche (PT) in girls. The aim of this study was to investigate the diagnostic usefulness of pelvic ultrasonography to distinguish between CPP and PT in girls with early breast development. METHODS: This study included girls with early breast development who visited the clinic between January 2012 and December 2013. Clinical, laboratory, and pelvic ultrasonographic data were evaluated...
August 2015: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26286459/growth-and-hormone-profiling-in-children-with-congenital-melanocytic-naevi
#6
R Waelchli, J Williams, T Cole, M Dattani, P Hindmarsh, H Kennedy, A Martinez, S Khan, R K Semple, A White, N Sebire, E Healy, G Moore, V A Kinsler
BACKGROUND: Multiple congenital melanocytic naevi (CMN) is a rare mosaic RASopathy, caused by postzygotic activating mutations in NRAS. Growth and hormonal disturbances are described in germline RASopathies, but growth and hormone status have not previously been investigated in individuals with CMN. OBJECTIVES: To explore premature thelarche, undescended testes, and a clinically abnormal fat distribution with CMN through prospective endocrinological assessment of a cohort of subjects with CMN, and a retrospective review of longitudinal growth of a larger group of patients with CMN from outpatient clinics (which included all subjects in the endocrinological assessment group)...
December 2015: British Journal of Dermatology
https://www.readbyqxmd.com/read/26226120/amh-levels-at-central-precocious-puberty-and-premature-thelarche-is-it-a-parameter
#7
Nursel Muratoglu Sahin, Sibel Tulgar Kinik, Mustafa Agah Tekindal, Nilufer Bayraktar
BACKGROUND: The possible difference of antimüllerian hormone (AMH) levels at central precocious puberty (CPP) and premature thelarche (PT) has not been properly evaluated. OBJECTIVE/HYPOTHESIS: By evaluating AMH levels in girls with diagnosed CPP and PT, we aim to show the change of AMH levels at the pubertal onset. SUBJECTS: Sixty-five girls who have breast development before the age of 8 years and 25 healthy girls were enrolled in the study...
November 1, 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/26136989/testing-of-kisspeptin-levels-in-girls-with-idiopathic-central-precocious-puberty-and-its-significance
#8
Y U Yang, Xiang-Yu Xiong, L I Yang, Liling Xie, Hui Huang
The aim of this study was to explore the significance of plasma kisspeptin levels in diagnosis and therapeutic evaluation through the analysis of the kisspeptin levels of girls diagnosed with idiopathic central precocious puberty (ICPP) prior to treatment and after 6-months of treatment and those with simple premature thelarche (PT). A total of 70 girls including 24 girls diagnosed with ICPP, 21 girls with PT and 25 normal girls were enrolled in the study. ELISA analysis was conducted to detect the plasma levels of kisspeptin...
June 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26132407/a-dilemma-premature-thelarche-or-normal-pubertal-development
#9
Erkan Sari, Mustafa Gulgun, Adem Polat, Ediz Yesilkaya
No abstract text is available yet for this article.
September 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26078693/clinical-and-laboratory-findings-in-the-differential-diagnosis-of-central-precocious-puberty-and-premature-thelarche
#10
Gönül Çatlı, Pınar Erdem, Ahmet Anık, Ayhan Abacı, Ece Böber
AIM: In this study, it was aimed to evaluate the clinical, antropometric and laboratory findings of female patients diagnosed with central precocious puberty and to determine the laboratory value with the best diagnostic accuracy in the diagnosis of central precocious puberty. MATERIALS AND METHOD: Female patients whose breast development began before the age of 8 years were included in the study. The data of the patients were obtained by retrospectively examining file records...
March 2015: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/26030789/clinical-characteristics-of-children-referred-for-signs-of-early-puberty-before-age-3
#11
Paul B Kaplowitz, Rinku Mehra
BACKGROUND: Signs of puberty in very young children are often benign, but the evaluation needed and follow-up are controversial. OBJECTIVES: The study had three objectives: 1) to analyze the frequency of diagnoses in children <3 years referred for early puberty; 2) to examine the usefulness of lab testing; and 3) to identify red flags indicating a more serious diagnosis. METHODS: Charts of all children younger than age 3 referred for early puberty between 7/09 and 6/13 were reviewed...
September 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/25833360/serum-nesfatin-1-and-leptin-levels-in-non-obese-girls-with-premature-thelarche
#12
G Çatlı, A Anık, T Küme, Ö G Çalan, B N Dündar, E Böber, A Abacı
AIM: We aimed to investigate serum nesfatin-1 level in girls with premature thelarche (PT) and its relationship with anthropometric parameters and leptin, which are involved in the initiation of pubertal process. SUBJECTS-METHODS: Non-obese girls who presented with the complaint of early (2-8 years) and isolated breast development were included in the study. The control group consisted of age-matched healthy prepubertal girls. Auxological measurements were performed in all subjects...
August 2015: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/25800475/higher-body-fat-and-lower-fat-free-mass-in-girls-with-premature-adrenarche
#13
COMPARATIVE STUDY
Ayşe Nurcan Cebeci, Ayşegül Taş
OBJECTIVE: Idiopathic premature adrenarche (PA) refers to presence of androgenic signs before the age of eight years in girls in the absence of thelarche. In children with PA, increased adrenal androgens lead to changes in body composition and transient growth acceleration. Although the association between PA and some components of the metabolic syndrome is well known, body composition has not been extensively studied in these patients. METHODS: We examined 47 girls with PA with a median age of 7...
March 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/25714294/ultrasound-assessment-of-breast-development-distinction-between-premature-thelarche-and-precocious-puberty
#14
COMPARATIVE STUDY
Inyoung Youn, Sung Hee Park, In Seok Lim, Soo Jin Kim
OBJECTIVE. We analyzed the correlation between breast development and ultrasound-measured breast bud diameter. We also evaluated different breast ultrasound findings in pediatric subjects with precocious puberty and premature thelarche while comparing bone age and hormone levels. MATERIALS AND METHODS. We performed a retrospective study with a sample of 90 girls (mean age, 7.8 years) who underwent breast ultrasound for evaluation of early breast development between March 2011 and February 2013. We evaluated breast ultrasound grade, bud diameter, and clinical characteristics including bone age and hormone levels...
March 2015: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/25703757/precocious-puberty-in-children
#15
Irum Atta, Taj Muhammad Laghari, Yasir Naqi Khan, Saira Waqar Lone, Mohsina Ibrahim, Jamal Raza
OBJECTIVE: To determine the etiology of precocious puberty in children and to compare the clinical and laboratory parameters of central and peripheral precocious puberty. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Endocrine Clinic at National Institute of Child Health, Karachi, from January 2009 to December 2011. METHODOLOGY: Children presenting with precocious puberty were included. The age of onset of puberty was documented...
February 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/25572302/significance-of-serum-neurokinin-b-and-kisspeptin-levels-in-the-differential-diagnosis-of-premature-thelarche-and-idiopathic-central-precocious-puberty
#16
Ayhan Abacı, Gönül Çatlı, Ahmet Anık, Tuncay Küme, Özlem Gürsoy Çalan, Bumin Nuri Dündar, Ece Böber
The aim of the present study was to investigate the diagnostic role of serum neurokinin B level and its relationship with kisspeptin and leptin, which are known to be involved in the initiation of pubertal process. Girls who presented with breast development (<8 years) were included in the study. All patients underwent bone age assessment. Basal levels of serum follicle stimulating hormone and luteinizing hormone were measured and gonadotropin releasing hormone stimulation test was performed. Patients with a bone age/chronological age ratio >1 and a peak luteinizing hormone response in gonadotropin releasing hormone stimulation test >5mIU/L were included in the central precocious puberty group, while patients who did not meet these criteria were included in the premature thelarche group...
February 2015: Peptides
https://www.readbyqxmd.com/read/25514323/evaluation-of-puberty-by-verifying-spontaneous-and-stimulated-gonadotropin-values-in-girls
#17
Vivian L Chin, Ziyong Cai, Leslie Lam, Bina Shah, Ping Zhou
BACKGROUND: Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test. OBJECTIVE: To determine the best predictive model for detecting puberty in girls. SUBJECTS: Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche/premature adrenarche (n=15). METHODS: Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram...
March 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/25336100/urinary-zearalenone-levels-in-girls-with-premature-thelarche-and-idiopathic-central-precocious-puberty
#18
A Asci, E Durmaz, P Erkekoglu, D Pasli, I Bircan, B Kocer-Gumusel
AIM: Recently, it was reported that the development of breast tissue and secondary sex characteristics in girls occurred at much younger age and the incidences of premature thelarce (PT) and central idiopathic precocious puberty (ICPP) are increasing. In this context, we wanted to evaluate the mycoestrogen exposure as triggering factor for premature sexual development. METHODS: The girls living in Mediterranean region of Turkey were divided in to three groups: control (N...
December 2014: Minerva Pediatrica
https://www.readbyqxmd.com/read/25242967/etiology-of-precocious-puberty-10-years-study-in-endocrine-reserch-centre-firouzgar-tehran
#19
Farzaneh Rohani, Shadab Salehpur, Fatemeh Saffari
BACKGROUND: Precocious puberty, as early physical development and low final height might lead to psychosocial problems. OBJECTIVE: To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children. MATERIALS AND METHODS: In this case-series study, 44 girls and 8 boys with precocious puberty referred to Endocrine Reserch Centre (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), were examined in a 10 years period of time...
January 2012: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25159103/is-there-a-role-for-estrogen-activity-assays-recombinant-cell-bioassay-for-estrogen-development-and-applications
#20
REVIEW
Karen Oerter Klein
There are many questions which cannot be answered without a very sensitive estradiol assay. A recombinant cell bioassay (RCBA) for estradiol was developed in 1994. The sensitivity of the bioassay is 0.02-0.2 pg/ml (0.07-0.7 pmol/L), more than 20 times more sensitive than commercial RIAs and 10 times more sensitive than newer mass spectrometry assays. The RCBA for estradiol opened the door to study low levels of estradiol equivalents (EE) across the physiological spectrum of life from prepubertal children through menopause and across the spectrum from normal physiology, in boys as well as girls, to pathology, including: premature thelarche; estradiol suppression in children treated with GnRH analogues for precocious puberty; aromatase inhibition in boys with growth hormone deficiency; the differences between oral and transdermal routes of estrogen administration in girls with Turner's syndrome; women with breast cancer treated with aromatase inhibitors; and women with urogenital atrophy treated with low dose vaginal estrogen...
July 2015: Steroids
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