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Bicuspid aortic valve

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https://www.readbyqxmd.com/read/28330793/procedural-and-clinical-outcomes-in-transcatheter-aortic-valve-replacement-for-bicuspid-versus-tricuspid-aortic-valve-stenosis
#1
Sung-Han Yoon, Sabine Bleiziffer, Ole De Backer, Victoria Delgado, Takahide Arai, Johannes Ziegelmueller, Marco Barbanti, Rahul Sharma, Gidon Y Perlman, Omar K Khalique, Erik W Holy, Smriti Saraf, Florian Deuschl, Buntaro Fujita, Philipp Ruile, Franz-Josef Neumann, Gregor Pache, Masao Takahashi, Hidehiro Kaneko, Tobias Schmidt, Yohei Ohno, Niklas Schofer, William K F Kong, Edgar Tay, Daisuke Sugiyama, Hiroyuki Kawamori, Yoshio Maeno, Yigal Abramowitz, Tarun Chakravarty, Mamoo Nakamura, Shingo Kuwata, Gerald Yong, Hsien-Li Kao, Michael Lee, Hyo-Soo Kim, Thomas Modine, S Chiu Wong, Francesco Bedgoni, Luca Testa, Emmanuel Teiger, Christian Butter, Stephan M Ensminger, Ulrich Schaefer, Danny Dvir, Philipp Blanke, Jonathon Leipsic, Fabian Nietlispach, Mohamed Abdel-Wahab, Bernard Chevalier, Corrado Tamburino, David Hildick-Smith, Brian K Whisenant, Seung-Jung Park, Antonio Colombo, Azeem Latib, Susheel K Kodali, Jeroen J Bax, Lars Søndergaard, John G Webb, Thierry Lefèvre, Martin B Leon, Raj Makkar
BACKGROUND: Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS) is being increasingly performed. OBJECTIVES: From the Bicuspid AS TAVR multicenter registry, the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS were compared. METHODS: Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity-score matching assembling 546 pairs of patients with similar baseline characteristics...
March 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28325571/frequency-of-development-of-aortic-valve-disease-in-unrepaired-perimembranous-ventricular-septal-defects
#2
Asif Padiyath, Elizabeth S Makil, Katherine T Braley, Elijah H Bolin, Xinyu Tang, Jeffery M Gossett, R Thomas Collins
We sought to determine the natural history of aortic valve disease in patients with unrepaired perimembranous ventricular septal defects (pVSDs) and to identify echocardiographic parameters predictive of increased risk of surgical repair of pVSD because of aortic valve disease. We retrospectively analyzed all echocardiograms of patients with a diagnosis of pVSD at our institution from January 1999 to January 2015. All available echocardiographic data were collected. Patients were excluded if there was another structural cardiac anomaly other than bicuspid aortic valve, small patent foramen ovale, or ductus arteriosus...
February 28, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28325072/aortic-assessment-of-bicuspid-aortic-valve-patients-and-their-first-degree-relatives
#3
Pablo Straneo, Gabriel Parma, Natalia Lluberas, Alvaro Marichal, Gerardo Soca, Leandro Cura, Juan J Paganini, Daniel Brusich, Lucia Florio, Victor Dayan
Background Bicuspid aortic valve patients have an increased risk of aortic dilatation. A deficit of nitric oxide synthase has been proposed as the causative factor. No correlation between flow-mediated dilation and aortic diameter has been performed in patients with bicuspid aortic valves and normal aortic diameters. Being a hereditary disease, we compared echocardiographic features and endothelial function in these patients and their first-degree relatives. Methods Comprehensive physical examinations, routine laboratory tests, transthoracic echocardiography, and measurements of endothelium-dependent and non-dependent flow-mediated vasodilatation were performed in 18 bicuspid aortic valve patients (14 type 1 and 4 type 2) and 19 of their first-degree relatives...
March 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28318133/transcatheter-aortic-valve-implantation-with-the-self-expandable-venus-a-valve-and-corevalve-devices-preliminary-experiences-in-china
#4
Yan-Biao Liao, Zhen-Gang Zhao, Xin Wei, Yuan-Ning Xu, Zhi-Liang Zuo, Yi-Jian Li, Ming-Xia Zheng, Yuan Feng, Mao Chen
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has been demonstrated to be an effective alternative to surgical aortic valve replacement (SAVR) in patients with aortic stenosis who are deemed high risk or inoperable. Currently, TAVI procedures in China mostly make use of the domestic Venus A-Valve and the CoreValve; however, there is no data on their comparative performance. METHODS: Consecutive patients undergoing TAVI with the aforementioned devices were included...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28317480/novel-insights-into-complex-cardiovascular-pathologies-using-4d-flow-analysis-by-cardiovascular-magnetic-resonance-imaging
#5
Adam James Lewandowski, Betty Raman, Rajarshi Banerjee, Matteo Milanesi
BACKGROUND: It is essential that we are able to assess variations in blood flow in order to fully understand cardiovascular function in disease pathologies and for identification of individuals at long-term risk of cardiovascular disease development. Qualitative and quantitative assessments of blood flow by imaging modalities have been limited, and much of the accurate quantification has relied on invasive measures. METHODS: This review discusses how four-dimensional velocity cardiovascular magnetic resonance (4D flow CMR) offers increasing potential for the non-invasive assessment of blood flow in the heart and major blood vessels such as the aorta...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28299882/systolic-ejection-click-versus-split-first-heart-sound-are-our-ears-deceiving-us
#6
Natalie M Hoeting, Courtney E McCracken, Michael McConnell, Denver Sallee, Glen J Iannucci, Matthew E Oster
OBJECTIVE: Bicuspid aortic valve (BAV) disease is associated with potential lifetime complications, but auscultation of a BAV click is commonly missed or mistaken for a benign split first heart sound. Our objective was to determine whether pediatric cardiologists could reliably distinguish between BAV clicks and benign split first heart sounds. DESIGN: Quality evaluation project using de-identified recordings from an outpatient pediatric cardiology clinic. OUTCOME MEASURES: Twenty-one cardiologists listened to five de-identified recordings of pediatric heart sounds (three with BAV clicks, two with mitral components of benign split first heart sounds) and indicated whether they believed each recording was a BAV or split first heart sound...
March 16, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28299607/comprehensive-4-stage-categorization-of-bicuspid-aortic-valve-leaflet-morphology-by-cardiac-mri-in-386-patients
#7
I G Murphy, J Collins, A Powell, M Markl, P McCarthy, S C Malaisrie, J C Carr, A J Barker
Bicuspid aortic valve (BAV) disease is heterogeneous and related to valve dysfunction and aortopathy. Appropriate follow up and surveillance of patients with BAV may depend on correct phenotypic categorization. There are multiple classification schemes, however a need exists to comprehensively capture commissure fusion, leaflet asymmetry, and valve orifice orientation. Our aim was to develop a BAV classification scheme for use at MRI to ascertain the frequency of different phenotypes and the consistency of BAV classification...
March 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28290851/-degenerative-aortic-stenosis-modern-view-on-development-course-and-management
#8
A L Burdeinaya, M S Safarova, M V Ezhov, V V Kukharchuk
Degenerative aortic stenosis is an acquired heart defect manifesting as progressive thickening and calcification of leaflets of originally normal tricuspid or congenital bicuspid aortic valve with development of orifice narrowing, left ventricular hypertrophy, and high risk of cardiovascular complications. In this review we present modern concepts of formation and progression of degenerative aortic stenosis and discuss optimal methods of management of this disease.
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28272209/dissection-of-the-interventricular-septum-echocardiographic-features
#9
Xiaoyan Gu, Yihua He, Shurong Luan, Ying Zhao, Lin Sun, Hongjia Zhang, J V Ian Nixon
Dissection of the interventricular septum (IVS) is an extremely rare entity. An institutional echocardiographic database was retrospectively reviewed; 13 patients with a diagnosis of IVS dissection were found and confirmed by cardiac surgery. The purposes of the study were: to determine the value of transthoracic echocardiography (TTE) in establishing the diagnosis of IVS dissection, and to detail the TTE features of IVS dissection.Thirteen patients with IVS dissection diagnosed by TTE, 8 males and 5 females were taken from 789,114 TTE studies performed between 1985 and 2014...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28268005/feasibility-of-intraoperative-water-testing-in-aortic-valve-repair-direct-visualization-from-left-ventricle-with-a-videoscope
#10
Shunsuke Miyahara, Takanori Oka, Hiroaki Takahashi, Takeshi Inoue, Masamichi Matsumori, Hiroshi Tanaka, Yutaka Okita
OBJECTIVE: We describe a simple method to assess the aortic valve using a videoscope inserted in the left ventricle (LV-VS) during valve-sparing root replacement. The aim of this study was to evaluate the feasibility of this technique by comparing it with the findings of postoperative transesophageal echocardiography (TEE). METHODS: Thirty-six patients (29 male, mean age 45.4 ± 20.1 years) undergoing aortic root reimplantation were assessed intraoperatively with LV-VS...
February 10, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28268004/aortic-shear-stress-in-patients-with-bicuspid-aortic-valve-with-stenosis-and-insufficiency
#11
Yan Shan, Jun Li, Yongshi Wang, Boting Wu, Alex J Barker, Michael Markl, Chunsheng Wang, Xiaolin Wang, Xianhong Shu
OBJECTIVES: Bicuspid aortic valve, characterized by valve malformation and risk for aortopathy, displays profound alteration in systolic aortic outflow and wall shear stress distribution. The present study performed 4-dimensional flow magnetic resonance imaging in patients with bicuspid aortic valve with right-left cusp fusion, focusing on the impact of valve function on hemodynamic status within the ascending aorta. METHODS: Four-dimensional flow magnetic resonance imaging was performed in 50 subjects with right-left bicuspid aortic valve and 15 age- and aortic size-matched controls with tricuspid aortic valve...
February 10, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28267137/a-multimodality-approach-to-an-elderly-patient-with-aortic-coarctation-patent-ductus-arteriosus-and-bicuspid-aortic-valve
#12
Marta Kałużna-Oleksy, Sebastian Stefaniak, Magdalena Dudek, Jacek Migaj, Karolina Plaskota, Ewa Straburzyńska-Migaj
No abstract text is available yet for this article.
February 28, 2017: Pol Arch Intern Med
https://www.readbyqxmd.com/read/28262292/combined-aortic-root-replacement-and-mitral-valve-surgery-the-quest-to-preserve-both-valves
#13
Hoda Javadikasgari, Eric E Roselli, Muhammad Aftab, Rakesh M Suri, Milind Y Desai, Mitra Khosravi, Frank Cikach, Monica Isabella, Jay J Idrees, Sajjad Raza, Bassman Tappuni, Brian P Griffin, Lars G Svensson, A Marc Gillinov
OBJECTIVES: Coexisting aortic root and mitral valve pathology is increasingly recognized among patients undergoing surgery. We characterized the pathology and surgical outcomes of patients with combined aortic root and mitral disease. METHODS: From 1987 to 2016, 118 patients (age 52.40 ± 17.71 years) underwent concomitant aortic root and mitral procedures (excluding aortic stenosis, endocarditis, and reoperations). Aortic root pathologies included degenerative aneurysm (94%) and aortic dissection (6%)...
January 31, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28260551/bicuspid-aortic-valve-and-the-specialty-clinic-are-your-patients-at-risk
#14
Paul W M Fedak
No abstract text is available yet for this article.
March 6, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28256067/transcatheter-aortic-valve-replacement-the-year-in-review-2016
#15
Kishore J Harjai, Cindy L Grines, Jean-Michael Paradis, Susheel Kodali
Transcatheter aortic valve replacement (TAVR) continued to make major strides in 2016, simultaneously expanding its application to lower risk patients as well as more technically challenging subsets of patients with aortic stenosis (AS). The two major accomplishments this year were the establishment of TAVR as the preferred treatment strategy over surgical aortic valve replacement (SAVR) in intermediate risk patients, and initial signals that TAVR and SAVR may be clinically equivalent in low-risk populations...
March 2, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28251912/sex-differences-in-bicuspid-aortic-valve-adults-who-deserves-our-attention-men-or-women
#16
EDITORIAL
Hector I Michelena, Sunil V Mankad
No abstract text is available yet for this article.
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28251911/sex-differences-in-phenotypes-of-bicuspid-aortic-valve-and-aortopathy-insights-from-a-large-multicenter-international-registry
#17
William K F Kong, Madelien V Regeer, Arnold C T Ng, Louise McCormack, Kian Keong Poh, Tiong Cheng Yeo, Miriam Shanks, Sarah Parent, Roxana Enache, Bogdan A Popescu, James W Yip, Lawrence Ma, Vasileios Kamperidis, Enno T van der Velde, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: This large multicenter, international bicuspid aortic valve (BAV) registry aimed to define the sex differences in prevalence, valve morphology, dysfunction (aortic stenosis/regurgitation), aortopathy, and complications (endocarditis and aortic dissection). METHODS AND RESULTS: Demographic, clinical, and echocardiographic data at first presentation of 1992 patients with BAV (71.5% men) were retrospectively analyzed. BAV morphology and valve function were assessed; aortopathy configuration was defined as isolated dilatation of the sinus of Valsalva or sinotubular junction, isolated dilatation of the ascending aorta distal to the sinotubular junction, or diffuse dilatation of the aortic root and ascending aorta...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28248407/hemodynamic-changes-after-transcatheter-aortic-valve-implantation-during-sequential-follow-ups-in-patients-with-bicuspid-aortic-valve-compared-with-tricuspid-aortic-valve
#18
Tian-Yuan Xiong, Ming-Xia Zheng, Xin Wei, Yi-Jian Li, Yan-Biao Liao, Zhen-Gang Zhao, Yuan-Ning Xu, Hong Tang, Yuan Feng, Mao Chen
BACKGROUND: To investigate the individual sequential hemodynamic changes after transcatheter aortic valve implantation (TAVI), especially for patients with bicuspid aortic valve (BAV), in comparison with tricuspid aortic valve (TAV). METHODS: The study population comprised 85 patients with severe aortic stenosis who underwent TAVI for BAV (n = 49) or TAV (n = 36) with at least two serial echocardiographic follow-ups. Doppler echocardiography was scheduled to be performed at discharge and 1, 3, 6 months and 1 year after the procedure...
March 1, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28246602/notch1-mutations-in-aortic-stenosis-association-with-osteoprotegerin-rank-rankl
#19
Olga Irtyuga, Anna Malashicheva, Ekaterina Zhiduleva, Olga Freylikhman, Oxana Rotar, Magnus Bäck, Svetlana Tarnovskaya, Anna Kostareva, Olga Moiseeva
Background. The NOTCH pathway is known to be important in the pathogenesis of calcific aortic valve disease, possibly through regulators of osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANK), and its ligand (RANKL) system. The purpose of the present study was to search for possible associations between NOTCH1 gene mutations and circulating levels of OPG and soluble RANKL (sRANKL) in patients with aortic stenosis (AS). Methods. The study was performed on 61 patients with AS including 31 with bicuspid and 30 with tricuspid aortic valves...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28238238/bicuspid-aortic-valve-a-review-of-its-genetics-and-clinical-significance
#20
Lei Wang, Li Ming Wang, Wen Chen, Xin Chen
The aim of this review was to describe recent advancements in the understanding of bicuspid aortic valve (BAV). BAV is the most common congenital cardiac anomaly, and affects between 0.46% and 1.37% of the population. There is a male predominance of approximately 3:1.While isolated BAV is found in certain patients, it is often associated with other congenital cardiac lesions, including dilatation of the thoracic aorta, coarctation of the aorta and abnormalities of the coronary anatomy. In most cases, it remains undetected until the patient contracts infective endocarditis, or calcification occurs...
September 2016: Journal of Heart Valve Disease
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