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Bicuspid aortic valve

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https://www.readbyqxmd.com/read/29767458/overlapping-but-distinct-roles-for-notch-receptors-in-human-cardiovascular-disease
#1
REVIEW
J A N Meester, A Verstraeten, M Alaerts, D Schepers, L Van Laer, B L Loeys
The NOTCH signalling pathway is an essential pathway, involved in many cellular processes, including cell fate decision, cell proliferation, and cell death and important in the development of most organs. Mutations in genes encoding components of the NOTCH signalling pathway lead to a spectrum of congenital disorders. Over the past decades mutations in human NOTCH signalling genes have been identified in several diseases with cardiovascular involvement. NOTCH1 mutations have been described in bicuspid aortic valve disease, left-sided congenital heart disease, and Adams-Oliver syndrome...
May 16, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29759733/-all-inclusive-guidelines-on-bicuspid-aortic-valve-related-aortopathy
#2
EDITORIAL
Ho Jin Kim, Joon Bum Kim
No abstract text is available yet for this article.
April 21, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29748059/experience-with-the-axillary-artery-as-an-arterial-cannulation-site-in-patients-with-acute-type-a-aortic-dissection
#3
Arpit Talwar, Elvina Wiadji, Manu N Mathur
BACKGROUND: The optimal arterial cannulation site in patients undergoing surgical management of acute type A aortic dissection (ATAAD) remains controversial. The axillary artery is rarely involved in the dissection process, provides antegrade flow in the descending aorta and minimises intraoperative malperfusion. The purpose of this study is to evaluate a single surgeon's experience of axillary artery cannulation for ATAAD repair. METHODS: All consecutive patients over a 15-year period having surgical repair of ATAAD were included in this study...
March 29, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29747711/successful-transcarotid-transcatheter-aortic-valve-replacement-in-a-34-kg-patient-with-schimke-immuno-osseous-dysplasia-and-severe-biscuspid-aortic-stenosis
#4
Katie E O' Sullivan, Alan P Griffin, Ivan P Casserly
We present the case of transcatheter aortic valve replacement in a 20-year-old woman with severe bicuspid aortic stenosis and Schmike immuno-osseous dysplasia who was unfit for surgical aortic valve replacement. Meticulous pre-procedural planning and a multidisciplinary team approach can enable successful transcatheter aortic valve replacement in complex patients with genetic syndromes.
May 11, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29735267/uni-leaflet-mitral-valve-associated-with-bicuspid-aortic-valve
#5
D Gaitan Roman, A Aviles-Toscano, R Vivancos Delgado
No abstract text is available yet for this article.
May 4, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29733827/successful-use-of-sternal-sparing-minimally-invasive-surgery-for-proximal-ascending-aortic-pathology
#6
Joseph Lamelas, Peter C Chen, Gabriel Loor, Angelo LaPietra
BACKGROUND: A sternal-sparing approach to surgery of the proximal aorta could decrease postoperative morbidity. METHODS: To determine the potential benefits of using a minimally invasive right thoracotomy approach for the treatment of ascending aortic pathology, we retrospectively reviewed our experience in patients who required circulatory arrest for the treatment of ascending aortic pathology (with or without aortic valve involvement) between January 2009 and November 2014 (N=177)...
May 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29731785/aortic-coarctation-never-too-late-to-diagnose-never-too-late-to-treat
#7
L Conti, S Borg Savona, T Spiteri, J Degiovanni, A Borg, M Caruana
We present two cases of severe aortic coarctation detected in adulthood and who underwent successful relief by transcatheter stent deployment using a new covered stent, Optimus® stent (AndraTec GmbH Koblenz, Germany). One patient is a 46-year old female with resistant arterial hypertension, in whom coarctation was suspected on a follow-up transthoracic echocardiogram for bicuspid aortic valve disease and subsequently confirmed on magnetic resonance imaging. The second patient is a 68-year old male whose coarctation was diagnosed incidentally at coronary angiography being performed as part of the preoperative work-up for severe aortic stenosis...
July 2017: Images in Paediatric Cardiology
https://www.readbyqxmd.com/read/29731120/clinical-and-echocardiographic-prevalence-and-detection-of-congenital-and-acquired-cardiac-abnormalities-in-girls-and-women-with-the-turner-syndrome
#8
Anji T Yetman, Lois Starr, Jennifer Sanmann, Megan Wilde, Mary Murray, Jonathan W Cramer
The prevalence of congenital and acquired heart disease in patients with the Turner syndrome (TS) is based on historic cohorts who underwent imaging before the advent of modern day echocardiography. Recent small studies suggest a higher prevalence of cardiac defects. We reviewed clinical and echocardiographic data on 564 girls and women with TS to assess the prevalence of cardiac defects. Echocardiographic review on a subset of this population was performed to assess for diagnostic limitations of echocardiography in assessing for congenital and acquired defects in this patient cohort...
April 17, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29728065/prevalence-and-characteristics-of-primary-left-sided-valve-disease-in-a-cohort-of-15-000-patients-undergoing-echocardiography-studies-in-a-tertiary-hospital-in-uganda
#9
Joselyn Rwebembera, William Manyilirah, Zhang Wan Zhu, Juliet Nabbaale, Judith Namuyonga, Isaac Ssinabulya, Sulaiman Lubega, Peter Lwabi, John Omagino, Emmy Okello
BACKGROUND: Although rheumatic heart disease remains the leading cause of valve heart disease (VHD) in developing countries, other forms of valve disease have been over shadowed and not regarded as a public health problem. However, several facts suggest that the role of non-rheumatic VHD as a significant cardiovascular disease should be reconsidered. We aimed to assess the prevalence and characteristics of different forms of primary left sided valve diseases from a series of 15,009 echocardiographic studies...
May 4, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29716809/successful-transcatheter-aortic-valve-replacement-in-an-oversized-800-mm-2-annulus-and-bicuspid-aortic-valve
#10
Kyle D Buchanan, Toby Rogers, Christian Shults, Itsik Ben-Dor, Lowell F Satler, Ron Waksman
The current iterations of balloon-expandable transcatheter aortic valve replacement (TAVR) valves consist of a maximum size of 29 mm, corresponding to maximum annulus area of 680 mm2 . However, a number of patients who qualify for TAVR based on surgical risk may have anatomical features outside the FDA-approved descriptions. The technique of overexpansion of TAVR valves during deployment allows for more patients to be treated successfully. This particular case demonstrates that overexpansion is safe and efficacious in a very large annulus of >800 mm2 ...
March 29, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29701398/trauma-an-unusual-cause-of-endocarditis
#11
Ana Braga, Marta Marques, Miguel Abecacis, José Pedro Neves
INTRODUCTION: Infective endocarditis (IE) remains a dangerous condition with considerable associated mortality. Usual risk factors for IE include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a recent history of invasive procedures. METHODS: The authors describe the case report of a patient with IE having trauma as an unusual risk factor. RESULTS: A 33-year old male patient was referred to our department due to infective endocarditis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701363/david-operation-in-the-bicuspid-aortic-valve-population
#12
Pedro Magro, Marta Marques, Miguel Abecacis
INTRODUCTION: Bicuspid aortic valve (BAV) is the single most common cardiac congenital mal-formation with a prevalence of 1-2%. It is frequently associated with aortic disease including annular ectasia. Increasing evidence suggests that valve-sparing root re-implantation surgery combined with primary aortic valve repair can be performed with good midterm results in patients with BAV. METHODS: Our objective is to compare the short and long term results of David procedure in BAV patients with aortic root ectasia...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700864/bicuspid-and-tricuspid-aortic-valve-do-not-have-the-same-ascending-aorta-morphology
#13
N d'Ostrevy, H Ngo, B Magnin, K Azarnoush, L Cassagnes, L Camilleri
INTRODUCTION: Bicuspid aortic valves are associated with histopathological abnormalities of the aorta. Their diameters have been measured in several studies, but the literature concerning changes in the overall anatomy of the ascending aorta is limited. We wanted to know whether the anatomy of the valve, bicuspid or tricuspid, is associated with anatomical differences. MATERIALS AND METHODS: We prospectively included patients requiring aortic valve surgery. The protocol included a chest CT scan before the operation to determine the angulations and straight lengths of aortic segments 0 and 1...
April 26, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29698663/fate-of-the-aortic-arch-following-surgery-on-aortic-root-and-ascending-aorta-in-bicuspid-aortic-valve
#14
Rajdeep Bilkhu, Pouya Youssefi, Gopal Soppa, Panagiotis Theodoropoulos, Simon Phillips, Bernard Liban, Anne Child, Maite Tome, Justin Nowell, Rajan Sharma, Mark Edsell, Marjan Jahangiri
BACKGROUND: Recent guidelines support more aggressive surgery for aneurysms of the ascending aorta and root in patients with bicuspid aortic valve. However, the fate of the arch after surgery of the root and ascending aorta is unknown. We set out to assess outcomes following root and ascending aortic surgery and subsequent growth of the arch. METHODS: Between 2005 and 2016, 536 consecutive patients underwent surgery for aneurysm of the root and ascending aorta. 168 had bicuspid aortic valve...
April 23, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29697545/transcatheter-valvular-interventions-in-2017-some-things-old-some-things-new
#15
Hasan Rehman, Neal S Kleiman, Ankur Kalra
PURPOSE OF REVIEW: Transcatheter valvular interventions have changed the landscape of valvular therapies. We examine some studies on transcatheter valvular interventions published in the year 2017 to better understand their implications on clinical practice and future research. RECENT FINDINGS: Findings from the SURTAVI study suggest TAVR to be a reasonable option in intermediate risk patients with aortic stenosis. Recent studies indicate that valve leaflet thrombosis is associated with poor outcomes...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29695249/aortic-flow-patterns-and-wall-shear-stress-maps-by-4d-flow-cardiovascular-magnetic-resonance-in-the-assessment-of-aortic-dilatation-in-bicuspid-aortic-valve-disease
#16
José Fernando Rodríguez-Palomares, Lydia Dux-Santoy, Andrea Guala, Raquel Kale, Giuliana Maldonado, Gisela Teixidó-Turà, Laura Galian, Marina Huguet, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M Johnson, Oliver Wieben, David García-Dorado, Arturo Evangelista
BACKGROUND: In patients with bicuspid valve (BAV), ascending aorta (AAo) dilatation may be caused by altered flow patterns and wall shear stress (WSS). These differences may explain different aortic dilatation morphotypes. Using 4D-flow cardiovascular magnetic resonance (CMR), we aimed to analyze differences in flow patterns and regional axial and circumferential WSS maps between BAV phenotypes and their correlation with ascending aorta dilatation morphotype. METHODS: One hundred and one BAV patients (aortic diameter ≤ 45 mm, no severe valvular disease) and 20 healthy subjects were studied by 4D-flow CMR...
April 26, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29684119/aortic-stiffness-in-adolescent-turner-and-marfan-syndrome-patients
#17
Michal Schäfer, Lorna P Browne, Uyen Truong, James J Jaggers, Max B Mitchell, Ladonna Malone, Gareth Morgan, Kathryn Chatfield, Daniel McLennan, Harma Turbendian, Danial Vargas, Brian Fonseca, Michael DiMaria, Anar Shah, Margaret P Ivy, Alex J Barker, Kendall S Hunter, Neil Wilson, D Dunbar Ivy, David N Campbell
OBJECTIVES: Turner syndrome (TS) and Marfan syndrome (MFS) are partially characterized by aortopathies with a risk of developing severe aortic dilation, stiffness and consequent dissection and aneurysm formation. The incidence of a bicuspid aortic valve (BAV) is also increased in TS. We investigated aortic stiffness in teenage TS and MFS patients and evaluated to what degree stiffness in TS patients is augmented by the presence of a BAV. METHODS: Fifty-seven patients with TS (n = 37) and MFS (n = 20), as well as 22 controls with similar age and size distribution underwent evaluation of thoracic aortic stiffness using phase-contrast magnetic resonance imaging...
April 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29680713/bicuspid-aortic-valve-aortopathy-in-the-era-of-fake-news-a-clinician-s-perspective-on-the-truth
#18
EDITORIAL
Hector I Michelena
No abstract text is available yet for this article.
March 29, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29671812/enlightening-the-association-between-bicuspid-aortic-valve-and-aortopathy
#19
REVIEW
Froso Sophocleous, Elena Giulia Milano, Giulia Pontecorboli, Pierpaolo Chivasso, Massimo Caputo, Cha Rajakaruna, Chiara Bucciarelli-Ducci, Costanza Emanueli, Giovanni Biglino
Bicuspid aortic valve (BAV) patients have an increased incidence of developing aortic dilation. Despite its importance, the pathogenesis of aortopathy in BAV is still largely undetermined. Nowadays, intense focus falls both on BAV morphology and progression of valvular dysfunction and on the development of aortic dilation. However, less is known about the relationship between aortic valve morphology and aortic dilation. A better understanding of the molecular pathways involved in the homeostasis of the aortic wall, including the extracellular matrix, the plasticity of the vascular smooth cells, TGFβ signaling, and epigenetic dysregulation, is key to enlighten the mechanisms underpinning BAV-aortopathy development and progression...
April 19, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29666014/assessing-wall-stresses-in-bicuspid-aortic-valve-associated-aortopathy-forecasting-the-perfect-storm
#20
EDITORIAL
Alex J Barker, Michael Markl, Paul W M Fedak
No abstract text is available yet for this article.
March 31, 2018: Journal of Thoracic and Cardiovascular Surgery
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