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Bicuspid aortic valve

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https://www.readbyqxmd.com/read/28533581/bicuspid-aortic-valve-an-unusual-cause-of-aneurysm-of-left-coronary-sinus-of-valsalva
#1
Euden Bhutia, Dinesh Kumar, Binoy Shankar, Shakti Pad Das, Sunil Kishore
Bicuspid aortic valve is traditionally considered an innocuous congenital anomaly. Due to a better and widespread availability of non-invasive imaging techniques, it has come to the fore that 30% of these cases develop complications, viz., valve abnormality (aortic regurgitation and stenosis), and aneurysm of aortic root and ascending aorta. Sinus of Valsalva aneurysm is an uncommon complication of bicuspid aortic valve and more so those arising from the left coronary sinus are the rarest. These complications generally occur in the third or fourth decade of life...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28532768/prevalence-and-complications-of-bicuspid-aortic-valve-in-chinese-according-to-echocardiographic-database
#2
Yijian Li, Xin Wei, Zhengang Zhao, Yanbiao Liao, Jialing He, Tianyuan Xiong, Yuanning Xu, Wenyu Lv, Yuanweixiang Ou, Hong Tang, Yuan Feng, Mao Chen
As transcatheter aortic valve replacement has become an alternative treatment for patients at high risk for surgical aortic valve replacement, bicuspid aortic valve (BAV) draws our attention again. The reported frequency of BAV was 0.5% to 2% in western population. However, there was no such epidemiologic study in Chinese population. Our study sought to investigate the prevalence and complications of BAV in China by echocardiographic database. A total of 668 cases who were confirmed with BAV, identified from 195,708 echocardiographic records of 157,039 patients in the echocardiographic database of West China Hospital (between June 2008 and June 2012), were analyzed retrospectively...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28522032/left-ventricular-noncompaction-associated-with-bicuspid-aortic-valve-and-aortic-coarctation
#3
Nestor A Parra-Ordoñez, Nydia Avila-Vanzzini, Nilda Espinola-Zavaleta
No abstract text is available yet for this article.
May 15, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28515127/a-retrospective-analysis-of-mitral-valve-pathology-in-the-setting-of-bicuspid-aortic-valves
#4
Annari van Rensburg, Philip Herbst, Anton Doubell
The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid aortic valves to determine the need for closer echocardiographic scrutiny/follow-up of the mitral valve. A retrospective analysis of echocardiograms done at a referral hospital over five years was conducted in patients with bicuspid aortic valves with special attention to congenital abnormalities of the mitral valve...
May 17, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28501375/transthoracic-echocardiography-versus-computed-tomography-for-ascending-aortic-measurements-in-patients-with-bicuspid-aortic%C3%A2-valve
#5
Jae Yoon Park, Thomas A Foley, Crystal R Bonnichsen, Matthew J Maurer, Krista M Goergen, Vuyisile T Nkomo, Maurice Enriquez-Sarano, Eric E Williamson, Hector I Michelena
BACKGROUND: Ascending aorta dilatation is common in bicuspid aortic valve (BAV). The aim of this study was to investigate agreement of transthoracic echocardiographic (TTE) measurement of the sinuses of Valsalva and the tubular mid-ascending aorta (Asc-Ao) compared with electrocardiographically gated computed tomographic angiographic (CTA) assessment in patients with BAV. METHODS: Fifty-three patients with BAV (mean age, 54 ± 14 years; 74% men) who underwent both TTE and CTA imaging for ascending aortic assessment were retrospectively identified...
May 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28495059/bicuspid-aortic-valve-aortopathy-is-not-cancer
#6
EDITORIAL
Thoralf M Sundt
No abstract text is available yet for this article.
April 7, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28491793/bicuspid-aortic-valve-supporting-supravalvular-substrate-for-multiple-ventricular-tachycardias
#7
Saurabh Kumar, William G Stevenson, Usha B Tedrow
No abstract text is available yet for this article.
March 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28490615/contemporary-natural-history-of-bicuspid-aortic-valve-disease-a-systematic-review
#8
REVIEW
Ahmad Masri, Lars G Svensson, Brian P Griffin, Milind Y Desai
We performed a systematic review of the current state of the literature regarding the natural history and outcomes of bicuspid aortic valve (BAV). PubMed and the reference lists of the included articles were searched for relevant studies reporting on longitudinal follow-up of BAV cohorts (mean follow-up ≥2 years). Studies limited to patients undergoing surgical interventions were excluded. 13 studies (11 502 patients with 2-16 years of follow-up) met the inclusion criteria. There was a bimodal age distribution (30-40 vs ≥50 years), with a 3:1 male to female ratio...
May 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28485110/the-role-of-neo-sinus-reconstruction-in-aortic-valve-sparing-surgery
#9
Mario Gaudino, Antonino Di Franco, Luca Weltert, Umberto Benedetto, Christopher Lau, Ivancarmine Gambardella, Ruggero De Paulis, Leonard N Girardi
AIMS: The aim of this study was to evaluate the clinical and echocardiographic results and the predictors of outcomes in patients undergoing valve-sparing operation (VSO) at two aortic centers. In addition, we sought to evaluate the potential effect of recreation of the sinuses of Valsalva (SV) on the outcome of valve-sparing procedures. METHODS: During a 14-year period, 328 patients underwent aortic valve-sparing root replacement at two institutions. Clinical and echo evaluation was performed 6 months after surgery and every year thereafter or in case of clinical symptoms...
May 8, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28483205/aortic-diameter-growth-in-children-with-a-bicuspid-aortic-valve
#10
Remy Merkx, Anthonie L Duijnhouwer, Evelien Vink, Jolien W Roos-Hesselink, Michiel Schokking
Knowledge of aortic growth in patients with bicuspid aortic valve (BAV) is essential to identify patients at risk for dissection, but data on children remain unclear. We retrospectively evaluated the aortic diameters of all pediatric BAV patients, identified through an echocardiographic database (2005 to 2013). Medical records were reviewed and aortic diameters re-measured on echocardiographic images at diagnosis and if available on variable mid- and endpoints follow-up. Dilatation (z-score >2) was based on 2 different z-score equation methods (Gautier/Campens)...
April 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28476449/an-unusual-left-ventricular-finding-in-a-patient-with-bicuspid-aortic-valve-stenosis
#11
Ting Hai, Yannis Amador, Luyang Jiang, Hui Ju, Chao Yu, Yi Feng, Feroze Mahmood
No abstract text is available yet for this article.
February 12, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28469692/complex-ebstein-s-anomaly-in-an-86-year-old-iranian-man-a-case-report
#12
Bahieh Moradi, Farideh Roshanali
Ebstein's anomaly is defined as the significant apical displacement of the tricuspid valve causing tricuspid regurgitation. Although a variety of concomitant lesions have been previously described, we herein introduce an unusual presentation. Our patient was an 86-year-old man with a primary presentation of typical chest pain in the setting of recently diagnosed coronary artery disease with concomitant Ebstein's anomaly. We found mild-to-moderate tricuspid regurgitation, bicuspid aortic valve, persistent left superior vena cava, and patent foramen ovale...
January 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28467501/metabolomic-profiling-of-ascending-thoracic-aortic-aneurysms-and-dissections-implications-for-pathophysiology-and-biomarker-discovery
#13
Christian Doppler, Kathrin Arnhard, Julia Dumfarth, Katharina Heinz, Barbara Messner, Christian Stern, Therese Koal, Kristaps Klavins, Katarina Danzl, Florian Pitterl, Michael Grimm, Herbert Oberacher, David Bernhard
OBJECTIVE: Our basic understanding of ascending thoracic aortic aneurysm (ATAA) pathogenesis is still very limited, hampering early diagnosis, risk prediction, and development of treatment options. "Omics"-technologies, ideal to reveal tissue alterations from the normal physiological state due to disease have hardly been applied in the field. Using a metabolomic approach, with this study the authors seek to define tissue differences between controls and various forms of ATAAs. METHODS: Using a targeted FIA-MS/MS metabolomics approach, we analysed and compared the metabolic profiles of ascending thoracic aortic wall tissue of age-matched controls (n = 8), bicuspid aortic valve-associated aneurysms (BAV-A; n = 9), tricuspid aortic valve-associated aneurysms (TAV-A; n = 14), and tricuspid aortic valve-associated aortic dissections (TAV-Diss; n = 6)...
2017: PloS One
https://www.readbyqxmd.com/read/28465987/a-ruptured-mitral-valve-aneurysm-as-complication-of-a-bicuspid-aortic-valve-endocarditis
#14
Francesca Muscente, Michele Scarano, Daniela Clemente, Franco Pezzuoli, Vito Maurizio Parato
We present a case of a ruptured mitral valve (MV) aneurysm as a complication of a bicuspid aortic valve (BAV) endocarditis. It is about a young 35-year-old man, admitted to Cardiology Unit because of unexpected heart failure picture. We found a BAV endocarditis complicated by anterior MV-anterior leaflet aneurysm formation and subsequent severe MV regurgitation caused by aneurysm perforation. It was a particular and rare situation characterized by an infection of anterior mitral leaflet secondary to an infected regurgitant jet of a primary aortic infective endocarditis due to a BAV...
January 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/28461798/transcatheter-aortic-valve-implantation-in-a-patient-with-unicuspid-aortic-valve
#15
Angelo Nascimbene, Pranav Loyalka, Igor D Gregoric, Ricardo Bellera, Maan Malahfji, Marija Petrovic, Biswajit Kar
Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valves has been successfully performed, but there is a lack of published experience in percutaneous treatment of patients with unicuspid valves and severe aortic stenosis. We describe a case of TAVR in such a patient. A 31-year-old woman with Turner syndrome-who had undergone coarctation repair via subclavian flap at age 7 days and an aortic valvotomy at age 6 weeks-presented with severe symptomatic aortic stenosis. She was deemed inoperable because of her severe pulmonary hypertension and numerous comorbidities; consequently, a 20-mm Edwards Sapien 3 Transcatheter Heart Valve was offered for compassionate use...
April 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28444195/dna-methylome-analysis-reveals-distinct-epigenetic-patterns-of-ascending-aortic-dissection-and-bicuspid-aortic-valve
#16
Sun Pan, Hao Lai, Yiru Shen, Charles Breeze, Stephan Beck, Tao Hong, Chunsheng Wang, Andrew E Teschendorff
Aims: Epigenetics may mediate the effects of environmental risk factors on disease, including heart disease. Thus, measuring the DNA methylome offers the opportunity to identify novel disease biomarkers and novel insights into disease mechanisms. The DNA methylation landscape of ascending aortic dissection (AD) and bicuspid aortic valve (BAV) with aortic aneurysmal dilatation remain uncharacterized. The present study aimed to explore the genome-wide DNA methylation landscape underpinning these two diseases...
May 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28434646/factors-determining-aortic-valve-dysfunction-in-korean-subjects-with-a-bicuspid-aortic-valve
#17
Soo Youn Lee, Chi Young Shim, Darae Kim, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
Bicuspid aortic valve (BAV) disease has a male predominance of approximately 3:1 and shows diverse presentations about aortic valve dysfunction. This study aimed to find independent determinants for significant aortic stenosis (AS) or significant aortic regurgitation (AR) in adults with BAV. We retrospectively investigated the medical records of 1,073 subjects (773 men, mean age 55 ± 14 years) who were first diagnosed with BAV disease by transthoracic echocardiography. We excluded 52 subjects with both significant AS and significant AR...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28429692/pulmonary-artery-and-right-ventricle-function-in-patients-with-bicuspid-aortic-valve
#18
Çetin Geçmen, Gamze Babür Güler, Suzan Hatipoğlu, Muzaffer Kahyaoğlu, Murat Çap, Servet İzci, Çağatay Önal, Emrah Erdoğan, Aykun Hakgör, Özkan Candan, Arzu Kalaycı, Tuba Unkun, İbrahim Akın İzgi
OBJECTIVE: Bicuspid aortic valve (BAV) is a complex developmental anomaly caused by abnormal aortic leaflet formation during valvulogenesis. The present study is an assessment of the effects of BAV disease on the ascending aorta and pulmonary artery (PA), and an evaluation of the consequences for systolic and diastolic functioning of the left and right ventricles. METHODS: Total of 66 patients were eligible for inclusion. Pulmonary artery maximum diameter (PAD) was obtained 1 cm distal to the pulmonary annulus...
April 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28420669/a-possible-early-biomarker-for-bicuspid-aortopathy-circulating-transforming-growth-factor-beta-1-to-soluble-endoglin-ratio
#19
Amalia Forte, Ciro Bancone, Gilda Cobellis, Marianna Buonocore, Giuseppe Santarpino, Theodor Fischlein, Marilena Cipollaro, Marisa De Feo, Alessandro Della Corte
Rationale: The pathogenesis of bicuspid aortic valve (BAV)-associated aortopathy is poorly understood and no prognostic biomarker is currently available. Objective: We aimed to identify putative circulating biomarkers pathogenetically and prognostically linked to bicuspid aortopathy. Methods and Results: By RT-PCR, we evaluated gene expression variations (versus normal aorta) of transforming growth factor-beta1 (TGF-β1), connective tissue growth factor (CTGF), matrix metalloproteinase-2 (MMP-2), MMP-14, endoglin (ENG) and superoxide dismutase 3 (SOD3) in ascending aorta samples from 50 tricuspid and 70 BAV patients undergoing surgery for aortic stenosis (aorta diameter ≤45mm: BAVnon-dil or >45mm: BAVdil)...
April 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28413030/the-role-matrix-metalloproteinases-in-the-production-of-aortic-aneurysm
#20
Simon W Rabkin
Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and the destruction of extracellular matrix (ECM). Furthermore, AAA have evidence of inflammation and the cellular elements involved in inflammation such as macrophages can produce and/or activate MMPs This chapter focuses on human aortic aneurysm that are not due to specific known genetic causes because this type of aneurysm is the more common type...
2017: Progress in Molecular Biology and Translational Science
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