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obliterans bronchiolitis

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https://www.readbyqxmd.com/read/29775038/postinfectious-bronchiolitis-obliterans
#1
(no author information available yet)
La bronquiolitis obliterante es una enfermedad pulmonar crónica infrecuente y grave producto de una lesión del tracto respiratorio inferior. En nuestro país, es más frecuente observarla secundaria a una lesión viral grave, en especial, por adenovirus. La bronquiolitis obliterante se caracteriza por la oclusión parcial o total del lumen de los bronquiolos respiratorios y terminales por tejido inflamatorio y fibrosis, que produce la obstrucción crónica de la vía aérea. Este consenso discute el estado actual del conocimiento en las diferentes áreas de la bronquiolitis obliterante secundaria a una lesión infecciosa...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29774598/evaluation-of-current-strategies-for-surveillance-and-management-of-donor-specific-antibodies-single-center-study
#2
Daniel Sullivan, Chul Ahn, Ang Gao, Chantale Lacelle, Fernando Torres, Srinivas Bollineni, Amit Banga, Jessica Mullins, Manish Mohanka, Steve Ring, Michael Wait, Matthias Peltz, Pavan Duddupudi, Dhiraj Surapaneni, Vaidehi Kaza
BACKGROUND: Although, presence of donor specific antibodies (DSA) is known to impact lung allograft, limited data exists regarding DSA management. METHODS: We did a retrospective study at our center evaluating DSA management in adult lung transplant recipients undergoing lung transplantation between January 1, 2010 and June 30, 2014. Study follow up was completed through October 2017. All recipients were stratified into two groups based on the presence or absence of DSA...
May 17, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29771243/breath-volatile-organic-compounds-of-lung-transplant-recipients-with-and-without-chronic-lung-allograft-dysfunction
#3
Lucas Küppers, Olaf Holz, Sven Schuchardt, Jens Gottlieb, Jan Fuge, Mark Greer, Jens Hohlfeld
Chronic lung allograft dysfunction (CLAD) with its clinical correlative of bronchiolitis obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently there are no established methods for the early diagnosis or prediction of BOS. To assess the feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between transplant patients without and different stages of BOS...
May 17, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29751799/the-aging-lung-tissue-telomere-shortening-in-health-and-disease
#4
Stephanie Everaerts, Elise J Lammertyn, Dries S Martens, Laurens J De Sadeleer, Karen Maes, Aernoud A van Batenburg, Roel Goldschmeding, Coline H M van Moorsel, Lieven J Dupont, Wim A Wuyts, Robin Vos, Ghislaine Gayan-Ramirez, Naftali Kaminski, James C Hogg, Wim Janssens, Geert M Verleden, Tim S Nawrot, Stijn E Verleden, John E McDonough, Bart M Vanaudenaerde
BACKGROUND: Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently, telomere dynamics have not been established for the normal human lung nor for diseased lung tissue. We hypothesized an age- and disease-dependent shortening of lung tissue telomeres. METHODS: At time of (re-)transplantation or autopsy, 70 explant lungs were collected: from unused donors (normal, n = 13) and patients with cystic fibrosis (CF, n = 12), chronic obstructive pulmonary disease (COPD, n = 11), chronic hypersensitivity pneumonitis (cHP, n = 9), bronchiolitis obliterans syndrome (BOS) after prior transplantation (n = 11) and restrictive allograft syndrome (RAS) after prior transplantation (n = 14)...
May 11, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29683998/diagnosis-pathophysiology-and-experimental-models-of-chronic-lung-allograft-rejection
#5
Jason M Gauthier, Daniel Ruiz-Pérez, Wenjun Li, Ramsey R Hachem, Varun Puri, Andrew E Gelman, Daniel Kreisel
Chronic rejection is the Achilles' heel of modern lung transplantation, characterized by a slow, progressive decline in allograft function. Clinically, this manifests as obstructive disease, restrictive disease, or a mixture of the 2 depending on the underlying pathology. The 2 major phenotypes of chronic rejection include bronchiolitis obliterans syndrome and restrictive allograft syndrome. The last decade of research has revealed that each of these phenotypes has a unique underlying pathophysiology which may require a distinct treatment regimen for optimal control...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683731/bronchiolitis-obliterans-murine-model-induced-by-nitric-acid-aerosol-inhalation-an-economical-and-reproducible-model
#6
Jianing Yin, Xiaobo Ma, Fei Huang, Yucong Ma, Yanan Li
PURPOSE: Bronchiolitis obliterans (BO) is a highly debilitative and fatal syndrome associated with a series of severe lower airway disorders. The pathogenesis of BO is complicated and not entirely understood. An appropriate animal model of BO may aid research into its pathogenesis. Here, we establish a mouse model of BO to provide insight into this disease. MATERIALS AND METHODS: 6-8 week old BABL/c mice were exposed to 5% nitric acid (NA) aerosol through a nebulizer for 3 hours, and controls were exposed to distilled water instead...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29679771/extracorporeal-photopheresis-improves-survival-in-hematopoietic-cell-transplant-patients-with-bronchiolitis-obliterans-syndrome-without-significantly-impacting-measured-pulmonary-functions
#7
Mehrdad Hefazi, Kimberly J Langer, Nandita Khera, Jill Adamski, Vivek Roy, Jeffrey L Winters, Dennis A Gastineau, Eapen K Jacob, Justin D Kreuter, Manish J Gandhi, William J Hogan, Mark R Litzow, Shahrukh K Hashmi, Hemang Yadav, Vivek N Iyer, J P Scott, Mark E Wylam, Rodrigo Cartin-Ceba, Mrinal M Patnaik
We carried out the first matched retrospective cohort study aimed at studying the safety and efficacy of extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic cell transplantation (HCT). Medical records of 1325 consecutive adult patients who underwent HCT between 2005 and 2015 were reviewed. Seventy-four patients (median age, 51 years) with a diagnosis of BOS were included in the study. After propensity-score matching for BOS severity, 26 patients who underwent ≥3 months of ECP were matched to 26 non-ECP-treated patients, who were assigned an index date corresponding to the ECP start date for their matched pairs...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29650555/noninfectious-lung-complications-after-allogeneic-haematopoietic-stem-cell-transplantation
#8
Anne Bergeron, Sylvie Chevret, Régis Peffault de Latour, Karine Chagnon, Constance de Margerie-Mellon, Frédéric Rivière, Marie Robin, Jean Mani, Gwenael Lorillon, Gérard Socié, Abdellatif Tazi
Epidemiological data on late noninfectious pulmonary complications (LONIPCs) following allogeneic haematopoietic stem cell transplantation (HSCT) are derived exclusively from retrospective studies and conflicting. We aimed to evaluate prospectively their incidence, risk factors and outcomes.All consecutive patients scheduled to receive allogeneic HSCT between 2006 and 2008, at the university-teaching Saint Louis Hospital (Paris, France) were screened for inclusion. Eligible patients were those surviving at day 100...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29624575/montelukast-for-bronchiolitis-obliterans-syndrome-after-lung-transplantation-a-randomized-controlled-trial
#9
David Ruttens, Stijn E Verleden, Heleen Demeyer, Dirk E Van Raemdonck, Jonas Yserbyt, Lieven J Dupont, Bart M Vanaudenaerde, Robin Vos, Geert M Verleden
Bronchiolitis obliterans syndrome (BOS) remains the major problem which precludes long-term survival after lung transplantation. Previously, an open label pilot study from our group demonstrated a possible beneficial effect of montelukast in progressive BOS patients with low airway neutrophilia (<15%), and already on azithromycin treatment, in whom the further decline in pulmonary function was attenuated. This was, however, a non-randomized and non-placebo controlled trial. The study design is a single center, prospective, interventional, randomized, double blind, placebo-controlled trial, with a two arm parallel group design and an allocation ratio of 1:1...
2018: PloS One
https://www.readbyqxmd.com/read/29620080/neuromyelitis-optica-spectrum-disorder-in-the-elderly-associated-with-bronchiolitis-obliterans-organizing-pneumonia
#10
Aintzine Ruisanchez Nieva, Jose Luis Sanchez Menoyo, Ines Escalza Cortina, Nerea Foncea Beti, Marian Gomez Beldarrain, Juan Carlos Garcia-Monco
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29590671/primary-graft-dysfunction-pgd-following-lung-transplantation
#11
Rupal J Shah, Joshua M Diamond
Primary graft dysfunction (PGD) is a form of acute lung injury that results from ischemia reperfusion injury (IRI) and is the major cause of early posttransplant morbidity and mortality. Patients who survive PGD have decreased quality of life, an increased risk of chronic lung allograft dysfunction, specifically bronchiolitis obliterans syndrome, and a significantly increased risk of death. In 2017, the International Society for Heart and Lung Transplantation released updated consensus statements on the PGD definition, most up-to-date PGD risk factors, mechanisms of PGD development, and the state-of-the-art for PGD therapeutics...
April 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29580908/-extracorporeal-life-support-and-heart-lung-transplant-in-children
#12
Sébastien Hascoet, Angèle Boet, Karine Nubret, Marc Lilot, Séverine Feuillet, Nadir Benbrik, Julien Guihaire, Emmanuel Le Bret, Elie Fadel, Virginie Fouilloux, Pascal Amedro, Lucile Houyel, Bernard Kreitmann
Extracorporeal life support and heart and/or lung transplant are the last resort in children with end-stage cardiac and/or pulmonary failure and short-term life threaten. Currently, circulatory support is used as a bridge to recovery or as a bridge to transplant but not as a destination therapy. The Excor Berlin Heart is the long-lasting external pneumatic ventricular assist system that is currently available from infancy to adulthood. Long-term prognosis after pediatric cardiac and/or pulmonary transplant is conditioned by the occurrence of graft failure, coronary disease of the cardiac graft, viral infections and bronchiolitis obliterans of the pulmonary graft, the incidence of which increase with time...
March 23, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29579881/long-term-prognosis-after-lung-transplantation-a-monocentric-study-in-510-patients
#13
F Montoro Ballesteros, J J Sánchez Fernández, J M Vaquero Barrios, J Redel Montero, M J Cobos Ceballos, C Esteban Amarilla, A M Palomares Muriana, F Santos Luna
INTRODUCTION: Lung transplantation is the final treatment option in patients with respiratory failure. Morbidity and mortality rates associated with the management of complications is high despite advances. Postoperative complications include acute transplant rejection, bronchiolitis obliterans, and infections. Because of that, the success of this treatment option depends on the correct choice of donor and candidates to receive a transplant. OBJECTIVE: This study aims to perform a survival analysis of transplanted patients in our center and determine predictive variables of mortality...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29579768/chronic-lung-allograft-dysfunction-evolving-concepts-and-therapies
#14
Ariss DerHovanessian, W Dean Wallace, Joseph P Lynch, John A Belperio, S Sam Weigt
Lung transplantation has become an established therapeutic option for a variety of end-stage lung diseases. Technical advances in graft procurement, implantation, perioperative care, immunosuppression, and posttransplant medical management have led to significant improvements in 1-year survival, but outcomes after the first year have improved minimally over the last two decades. The main limitation to better long-term survival after lung transplantation is chronic lung allograft dysfunction (CLAD). CLAD also impairs quality of life and increases the costs of medical care...
April 2018: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29571601/high-circulating-cd4-cd25-hi-foxp3-t-cell-sub-population-early-after-lung-transplantation-is-associated-with-development-of-bronchiolitis-obliterans-syndrome
#15
Maxim Durand, Philippe Lacoste, Richard Danger, Lola Jacquemont, Carole Brosseau, Eugénie Durand, Gaelle Tilly, Jennifer Loy, Aurore Foureau, Pierre-Joseph Royer, Adrien Tissot, Antoine Roux, Martine Reynaud-Gaubert, Romain Kessler, Sacha Mussot, Claire Dromer, Olivier Brugière, Jean François Mornex, Romain Guillemain, Johanna Claustre, Nicolas Degauque, Antoine Magnan, Sophie Brouard
BACKGROUND: Chronic bronchiolitis obliterans syndrome (BOS) remains a major limitation for long-term survival after lung transplantation. The immune mechanisms involved and predictive biomarkers have yet to be identified. The purpose of this study was to determine whether peripheral blood T-lymphocyte profile could predict BOS in lung transplant recipients. METHODS: An in-depth profiling of CD4+ and CD8+ T cells was prospectively performed on blood cells from stable (STA) and BOS patients with a longitudinal follow-up...
March 20, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29569912/free-radical-production-and-oxidative-stress-in-lung-tissue-of-patients-exposed-to-sulfur-mustard-an-overview-of-cellular-and-molecular-mechanisms
#16
Asghar Beigi Harchegani, Eisa Tahmasbpour, Hojat Borna, Ali Imamy, Mostafa Ghanei, Alireza Shahriary
Sulfur mustard (SM) is a chemical alkylating compound that primary targets lung tissue. It causes a wide variety of pathological effects in respiratory system such as chronic bronchitis, bronchiolitis obliterans, necrosis of the mucosa and inflammation, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. However, molecular and cellular mechanisms for these pathologies are still unclear. Oxidative stress (OS) induced by reactive oxygen species (ROS) is likely a significant mechanism by which SM leads to cell death and tissues injury...
March 23, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29557913/extracorporeal-photopheresis-for-bronchiolitis-obliterans-syndrome-after-lung-transplantation
#17
Ramsey Hachem, Paul Corris
BACKGROUND: Lung transplantation is a therapeutic option for select patients with end-stage lung disease. However, successful lung transplantation is hampered by chronic lung allograft dysfunction (CLAD), in particular bronchiolitis obliterans syndrome (BOS). Although there is no approved or standard treatment for BOS, which may have several distinct phenotypes, extracorporeal photopheresis (ECP) has shown promising results in patients who develop BOS refractory to azithromycin treatment...
March 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29530952/microrna-17-92-is-required-for-t-cell-and-b-cell-pathogenicity-in-chronic-graft-versus-host-disease-in-mice
#18
Yongxia Wu, Steven Schutt, Katelyn Paz, Mengmeng Zhang, Ryan P Flynn, David Bastian, M Hanief Sofi, Hung Nguyen, Min Dai, Chen Liu, Ying-Jun Chang, Bruce R Blazar, Xue-Zhong Yu
Chronic graft-versus-host disease (cGVHD) is characterized as autoimmune-like fibrosis and antibody production mediated by pathogenic T cells and B cells. MicroRNA-17-92 (miR-17-92) influences the survival, differentiation, and function of lymphocytes in cancer, infections, and autoimmunity. To determine whether miR-17-92 regulates T- and B-cell responses in cGVHD, we generated mice conditionally deficient for miR-17-92 in T cells, B cells, or both. Using murine models of allogeneic bone marrow transplantation, we demonstrate that expression of miR-17-92 in donor T and B cells is essential for the induction of both scleroderma and bronchiolitis obliterans in cGVHD...
April 26, 2018: Blood
https://www.readbyqxmd.com/read/29529999/prevalence-of-pre-transplant-anti-hla-antibodies-and-their-impact-on-outcomes-in-lung-transplant-recipients
#19
Ji Eun Park, Chi Young Kim, Moo Suk Park, Joo Han Song, Young Sam Kim, Jin Gu Lee, Hyo Chae Paik, Song Yee Kim
BACKGROUND: Previous studies have suggested that antibodies against human leukocyte antigen (HLA) are associated with worse outcomes in lung transplantation. However, little is known about the factors associated with outcomes following lung transplantation in Asia. Accordingly, we investigated the prevalence of anti-HLA antibodies in recipients before transplantation and assessed their impact on outcomes in Korea. METHODS: A single-center retrospective study was conducted...
March 12, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29501285/impact-and-safety-of-open-lung-biopsy-in-patients-with-acute-respiratory-distress-syndrome-ards
#20
G Ortiz, M Garay, D Mendoza, P Cardinal-Fernández
INTRODUCTION: Acute respiratory distress syndrome (ARDS) is an inflammatory lung disorder, and its pathological hallmark is diffuse alveolar damage (DAD). Given that open lung biopsy (OLB) can sometimes result in severe side effects, it is rarely performed in patients with ARDS. AIM: The aims of this study were to describe: (a) the rate of treatment change associated with the histological result; and (b) the incidence of side effects induced by OLB. DESIGN AND PATIENTS: A retrospective, single-center, descriptive observational study was carried out in Hospital Santa Clara (Bogotá, Colombia) from February 2007 to January 2014...
February 28, 2018: Medicina Intensiva
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