Pieterjan Kerckhof, Gene P L Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens, Saskia Bos, Lynn Willems, Astrid Vermaut, Marie Vermant, Tinne Goos, Charlotte De Fays, Lucia Aversa, Yousry Mohamady, Arno Vanstapel, Michaela Orlitová, Jan Van Slambrouck, Xin Jin, Vimi Varghese, Iván Josipovic, Matthieu N Boone, Lieven J Dupont, Birgit Weynand, Adriana Dubbeldam, Dirk E Van Raemdonck, Laurens J Ceulemans, Ghislaine Gayan-Ramirez, Laurens J De Sadeleer, John E McDonough, Bart M Vanaudenaerde, Robin Vos
BACKGROUND: Chronic lung allograft dysfunction (CLAD) encompasses three main phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and a Mixed phenotype combining both pathologies. How the airway structure in its entirety is affected in these phenotypes is still poorly understood. METHODS: A detailed analysis of airway morphometry was applied to gain insights on the effects of airway remodelling on the distribution of alveolar ventilation in end-stage CLAD...
February 22, 2024: EBioMedicine